Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJWD62)

• Drug Name: phorbol 12-myristate 13-acetate Drug Info
• Synonyms: TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 2	[1]
Hodgkin lymphoma	2B30	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 27924
  ChEBI ID: CHEBI:37537
  CAS Number: CAS 16561-29-8
  TTD Drug ID: DMJWD62

Molecule-Related Drug Atlas

Drug(s) Targeting Calcium-activated potassium channel KCa4.1 (KCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[14]
iberiotoxin	DMRIG3O	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Transient receptor potential cation channel V4 (TRPV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2798745	DM7V96W	Heart failure	BD10-BD13	Phase 2	[16]
citric acid	DM80YI7	Discovery agent	N.A.	Investigative	[17]
4-Pyridin-2-yl-piperazine-1-carboxylic acid amide	DMFC8Q4	Discovery agent	N.A.	Investigative	[18]
Pyrrolidin-1-yl-thiourea	DMYNZXC	Discovery agent	N.A.	Investigative	[18]
CAPSAZEPINE	DM4ATCI	Discovery agent	N.A.	Investigative	[19]
SC-0030	DMD2WEQ	Discovery agent	N.A.	Investigative	[20]
bisandrographolide	DMRSKGC	Discovery agent	N.A.	Investigative	[21]
GSK1016790A	DMDHZR1	Discovery agent	N.A.	Investigative	[22]
GSK2193874	DMY2XV3	Discovery agent	N.A.	Investigative	[23]
RN1734	DMA3ZXM	Discovery agent	N.A.	Investigative	[24]

Drug(s) Targeting Calcium-activated potassium channel KCa4.2 (KCNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[2]
iberiotoxin	DMRIG3O	Discovery agent	N.A.	Investigative	[25]

Drug(s) Targeting Inward rectifier potassium channel Kir3.4 (KCNJ5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PIP2	DMOZV7N	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[27]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[28]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[29]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[29]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[35]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[38]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[41]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[38]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[46]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[53]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[59]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[63]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[66]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[68]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[80]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[81]
Methysergide	DM1EF73	Migraine	8A80	Approved	[82]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[86]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[87]

Drug(s) Affected By Cornifin-B (SPRR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[90]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[90]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase K (TGM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[98]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[90]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]

Drug(s) Affected By Cornifin-A (SPRR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[93]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[29]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[105]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[109]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[110]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[111]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[115]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[120]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[124]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[128]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[128]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[132]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[138]

Drug(s) Affected By Erythroid transcription factor (GATA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[142]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[144]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[147]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[41]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[149]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[150]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[151]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[148]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[152]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[153]

Drug(s) Affected By Cytochrome b5 (CYB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Neprilysin (MME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[162]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[172]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[173]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[183]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[184]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[188]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[192]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]

Drug(s) Affected By Serine/threonine-protein kinase PAK 3 (PAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[197]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[198]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[207]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[59]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]

Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Bortezomib	DMNO38U	Leukemia		Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[221]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]

Drug(s) Affected By Replication factor C subunit 4 (RFC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[224]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[224]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[225]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[226]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[233]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[240]

Drug(s) Affected By Cryptochrome-1 (CRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Haloperidol	DM96SE0	Delirium		Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[244]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[246]

Drug(s) Affected By Dual specificity protein phosphatase 13A (DUSP13B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[72]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[249]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By General transcription factor IIH subunit 4 (GTF2H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[251]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[252]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[224]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[255]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]

Drug(s) Affected By Sperm-associated antigen 5 (SPAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[224]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[259]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Mestranol	DMG3F94	Contraception	QA21	Approved	[259]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[224]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By DNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[263]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[264]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[224]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[271]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[272]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[273]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[272]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[274]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[275]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[273]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[277]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[278]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Indomethacin	DMSC4A7	Bursitis		Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[289]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[291]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[293]
Mestranol	DMG3F94	Contraception	QA21	Approved	[294]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[295]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[303]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[304]
Haloperidol	DM96SE0	Delirium		Approved	[29]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[305]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[307]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[315]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[316]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[317]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[319]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[321]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[322]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[323]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[324]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[325]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[183]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[327]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[328]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[329]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[331]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[332]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[334]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[336]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[337]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[340]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[345]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[339]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[345]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[349]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[351]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[349]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[352]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[358]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[360]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[363]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[345]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[345]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[339]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[234]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[240]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[366]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[367]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]

Drug(s) Affected By Claudin-4 (CLDN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[370]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[371]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[372]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[370]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[375]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[375]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[374]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[377]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[381]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Selenium	DM25CGV	N. A.	N. A.	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[386]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[387]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[392]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[393]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[394]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[395]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[394]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[397]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[398]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[399]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[400]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[401]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[403]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[215]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[406]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]

Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[189]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[412]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[413]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[414]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[417]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[418]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[419]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[421]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[341]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[423]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[424]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[225]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[423]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[425]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[260]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[430]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[433]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Interleukin-33 (IL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[434]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[435]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[436]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[437]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[438]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[439]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[440]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[444]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[445]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[446]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[447]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[448]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[449]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[450]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[451]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[452]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[453]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[455]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[456]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[458]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[459]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[460]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[462]
Fructose	DM43AN2	Vomiting	MD90	Approved	[463]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[465]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[465]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[172]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[467]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[467]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[468]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[471]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Selenium	DM25CGV	N. A.	N. A.	Approved	[473]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[474]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[475]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[476]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[477]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[478]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[479]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[479]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[481]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[482]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[482]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[483]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[484]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[486]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[487]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[488]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[489]
Fructose	DM43AN2	Vomiting	MD90	Approved	[29]
Ketoprofen	DMRKXPT	Bursitis		Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[490]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[491]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[492]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[496]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[497]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[498]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[499]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[500]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[501]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[502]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[503]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[69]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[505]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[69]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[506]
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[508]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[509]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[510]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[511]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[512]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[514]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[341]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[515]

Drug(s) Affected By Fibrinogen gamma chain (FGG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[516]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]

Drug(s) Affected By Glycophorin-A (GYPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[141]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[518]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[519]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[520]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[521]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[29]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[522]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[523]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[524]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[525]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[526]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[527]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[528]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[529]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[531]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[29]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[532]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[533]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[534]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[114]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[535]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[536]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[537]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[538]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[539]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[540]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[541]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[541]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[411]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[543]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[544]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[305]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[545]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[190]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[141]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[547]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[548]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[549]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[345]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[550]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[369]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[552]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[553]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[554]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[555]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[556]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[557]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[558]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[559]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[560]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[450]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[561]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[562]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[563]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[560]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[564]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[565]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[566]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[567]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[568]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[569]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[477]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[570]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[572]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[573]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[574]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[575]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[206]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[576]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[578]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[579]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[316]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[580]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[581]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[582]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[583]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[331]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[585]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[587]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[588]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[589]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[590]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[592]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[593]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[594]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[595]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[598]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[74]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[599]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[599]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[600]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[601]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[602]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[486]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[603]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[438]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[604]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[605]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[606]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[607]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[607]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[607]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[608]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[609]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[610]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[611]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[612]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[613]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[499]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[614]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[497]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[610]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[611]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[615]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[616]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[617]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[618]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[619]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[620]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[621]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[623]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[624]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[625]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[626]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[627]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[628]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[629]

Drug(s) Affected By Protein kinase C gamma type (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[630]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[598]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[631]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[632]
NSC-1771	DMNXDGQ	Discovery agent	N.A.	Investigative	[633]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[420]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[634]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[635]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[636]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[506]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[637]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[638]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[638]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[464]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[639]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[640]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[641]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[642]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[643]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[644]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[645]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[437]
Fructose	DM43AN2	Vomiting	MD90	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[646]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[647]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[305]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[648]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[649]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[650]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[651]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[653]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[650]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[654]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[655]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[332]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[656]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[475]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[657]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[658]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[607]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[659]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[660]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[661]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[662]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[663]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[664]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[663]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[29]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[665]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[666]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[667]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[668]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[667]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[669]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[670]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[671]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[668]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Platelet glycoprotein Ib alpha chain (GP1BA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[496]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[673]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[674]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[675]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[676]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[676]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[677]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[678]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[253]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[679]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[680]
Terbutaline	DMD4381	Asthma	CA23	Approved	[681]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[682]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[683]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[684]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[685]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[686]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[687]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[688]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[255]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[689]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[687]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[690]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[691]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[527]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[692]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[693]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[690]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[694]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[695]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[29]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[29]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[566]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[696]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[697]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[462]

Drug(s) Affected By Cathepsin G (CTSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[698]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[699]
Y-40613	DM412IV	Discovery agent	N.A.	Investigative	[700]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[701]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[702]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[703]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[454]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[703]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[454]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[704]
Abciximab	DMJO6GV	Acute disease		Approved	[29]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[29]

Drug(s) Affected By Pleckstrin (PLEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[705]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[706]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[707]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[699]
5'-Guanosine-Diphosphate-Monothiophosphate	DMIARG7	Discovery agent	N.A.	Investigative	[708]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[709]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[710]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[711]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[712]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[713]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[714]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[715]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[420]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[716]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[717]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[716]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[420]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[718]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[718]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[719]
Methamphetamine	DMPM4SK	Anxiety		Approved	[720]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[721]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[721]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[718]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[722]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[9]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[723]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[712]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[724]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[725]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[726]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[727]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[728]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[729]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[602]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[730]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[731]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[732]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[635]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[733]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Selenium	DM25CGV	N. A.	N. A.	Approved	[734]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[644]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[735]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[736]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[737]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[183]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[738]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[739]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[738]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[740]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[741]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[742]

Drug(s) Affected By Granzyme B (GZMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[743]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[744]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[503]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[746]
Bortezomib	DMNO38U	Leukemia		Approved	[705]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[503]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[747]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[29]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[748]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[749]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[750]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[635]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[647]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[751]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[69]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[752]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[753]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[754]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[755]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[756]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[325]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[491]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[757]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[759]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[760]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[762]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[763]

Drug(s) Affected By T-cell-specific surface glycoprotein CD28 (CD28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[764]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[765]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[766]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[705]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[767]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[430]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[768]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[769]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[770]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[606]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[771]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[772]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[773]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[330]
Selenium	DM25CGV	N. A.	N. A.	Approved	[473]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[774]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[775]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[776]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[777]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[778]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[779]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[780]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[555]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]

Drug(s) Affected By Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[29]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[29]
Quinapril	DMR8H31	Chronic heart failure	BD1Z	Approved	[29]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[781]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[782]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[783]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[784]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[785]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[440]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[786]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[787]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[561]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[788]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[789]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[790]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[791]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[792]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[793]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[602]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[602]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[636]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[794]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[609]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[795]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[644]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[796]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[797]

Drug(s) Affected By Neural cell adhesion molecule 1 (NCAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[798]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[799]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[260]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[800]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[801]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[802]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[803]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[804]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[805]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[806]
Fructose	DM43AN2	Vomiting	MD90	Approved	[463]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[807]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[802]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[356]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[808]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[809]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[810]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[811]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[811]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[667]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[812]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[813]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[814]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[815]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[816]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[817]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[799]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[437]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[818]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[819]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[819]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[820]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[821]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[740]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[822]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[823]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[824]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[825]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[826]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[345]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[827]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[827]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[828]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[829]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[830]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[831]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[572]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[832]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[281]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[528]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[833]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[834]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[835]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[836]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[527]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[837]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[837]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[838]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[839]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[540]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[840]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[696]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[841]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[842]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[843]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[844]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[845]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[846]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[847]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[848]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[849]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[850]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[851]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[769]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[852]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[703]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[853]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[854]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[668]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[855]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[647]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[856]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[857]

Drug(s) Affected By Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[714]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[858]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[162]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[859]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[858]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[860]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[861]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[647]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[862]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[863]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[864]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[865]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[866]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[367]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]

Drug(s) Affected By Transcription factor PU.1 (SPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[867]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[868]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[869]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[870]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[871]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[872]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Haloperidol	DM96SE0	Delirium		Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[873]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[593]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[874]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[875]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[876]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[877]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[878]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[879]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[880]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[881]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[277]

Drug(s) Affected By Histidine decarboxylase (HDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[882]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[883]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[884]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[884]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[885]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[195]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[885]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[886]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[887]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[888]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[705]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[889]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[890]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[891]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[892]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[893]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[894]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[895]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[896]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[897]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[345]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[898]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[732]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[863]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[899]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[900]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[864]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[901]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[902]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[255]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[899]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[891]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[819]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[819]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[479]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]

Drug(s) Affected By Integrin alpha-L (ITGAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[604]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[903]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[904]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[903]
Bortezomib	DMNO38U	Leukemia		Approved	[705]

Drug(s) Affected By Interleukin-11 (IL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[905]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[906]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[907]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[822]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[907]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[908]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[909]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[907]

Drug(s) Affected By Macrophage scavenger receptor types I and II (MSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[910]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[911]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[912]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[913]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Bortezomib	DMNO38U	Leukemia		Approved	[705]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 4 (FUT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[914]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[916]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[674]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[641]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[497]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[611]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[585]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[917]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[918]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[919]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[501]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[920]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[337]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[428]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[921]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[922]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[360]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[923]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[924]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[925]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[926]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[927]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[928]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[140]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[94]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[929]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[930]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[757]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[558]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[448]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[656]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[931]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[474]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[932]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[899]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[354]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[454]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[415]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[933]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[934]

Drug(s) Affected By Protein kinase C eta type (PRKCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[935]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Indomethacin	DMSC4A7	Bursitis		Approved	[936]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[195]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[598]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[937]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[207]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[739]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[938]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[883]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[939]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[940]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[205]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[937]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[941]
Selenium	DM25CGV	N. A.	N. A.	Approved	[473]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[739]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[942]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[822]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[775]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]

Drug(s) Affected By C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[943]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[944]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[945]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[946]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[947]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[948]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[949]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[136]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[950]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[951]

Drug(s) Affected By Rhombotin-2 (LMO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[29]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[322]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[394]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[952]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[400]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[953]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[312]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[954]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[955]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[835]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[491]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[956]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[957]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[958]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[959]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[960]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[961]

Drug(s) Affected By Interleukin-1 receptor type 2 (IL1R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[515]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[962]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[955]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[963]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[964]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[965]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[954]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[491]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[956]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[966]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[585]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[967]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]

Drug(s) Affected By Hematopoietic progenitor cell antigen CD34 (CD34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[843]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[968]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[968]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[969]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[598]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[970]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[971]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[971]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[971]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[972]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[195]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[426]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[501]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[337]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[479]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[973]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[974]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[975]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[976]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[977]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[978]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[979]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[849]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[980]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[703]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[981]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[982]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[983]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[981]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[577]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[334]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[984]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[985]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[863]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[986]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]

Drug(s) Affected By Gastrin-releasing peptide receptor (GRPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[987]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[988]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[249]

Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[989]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[990]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[976]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[991]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[992]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[993]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[990]

Drug(s) Affected By Syndecan-4 (SDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[994]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[995]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[996]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[997]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[998]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[582]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[757]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[999]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[924]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1000]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[114]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[474]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[391]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[705]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[972]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[870]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1001]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1002]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1003]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1004]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[1005]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[598]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[1006]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1007]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[404]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1008]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1009]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1010]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[1011]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[916]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1012]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1012]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1013]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1014]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1015]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1016]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1017]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[746]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1017]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1018]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1019]

Drug(s) Affected By Macrosialin (CD68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1020]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[602]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[602]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Interleukin-13 (IL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1021]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1022]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[537]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[617]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[503]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1023]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[1024]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[617]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[503]

Drug(s) Affected By Histamine H1 receptor (HRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[1025]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[1025]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1026]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[251]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[1027]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[1028]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[1029]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1030]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[1031]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[1028]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1032]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1033]

Drug(s) Affected By Basigin (BSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1034]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[836]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[1034]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1035]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1034]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[125]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1036]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1037]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1038]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1039]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1040]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1041]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1042]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1043]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1044]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1045]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1046]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1047]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[408]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1048]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[305]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[656]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[184]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1049]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[739]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[835]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[133]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[133]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[992]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[1050]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[992]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[29]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1051]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1052]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1053]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1054]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1055]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1056]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[791]

Drug(s) Affected By Protein kinase C iota type (PRKCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1057]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[252]
Indomethacin	DMSC4A7	Bursitis		Approved	[1058]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[992]

Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1059]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1032]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[1060]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[1061]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1062]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[359]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[360]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[923]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1063]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[474]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1064]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1065]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[825]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1066]

Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1067]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[1067]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[870]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[988]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[135]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[250]
Dimethylallyl Diphosphate	DMP5I47	Discovery agent	N.A.	Investigative	[1068]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1069]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[646]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[493]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[648]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1070]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1071]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[648]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1072]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[646]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[648]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1073]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1074]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[648]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1075]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1076]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]

Drug(s) Affected By G-protein coupled receptor 3 (GPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[1077]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[1078]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[1079]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[655]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[448]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1049]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1073]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1080]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[450]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1081]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[938]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1082]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1083]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[367]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[637]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1084]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1085]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1086]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1087]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1088]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[763]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1089]

Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1090]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[585]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1091]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1090]
Bortezomib	DMNO38U	Leukemia		Approved	[705]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1092]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1093]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[859]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[1094]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[1095]

Drug(s) Affected By Serpin B9 (SERPINB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]

Drug(s) Affected By Calponin-1 (CNN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1096]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[251]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[556]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[982]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1097]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[556]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]

Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1099]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[1100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[1101]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1101]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[1102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1101]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1103]

Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1104]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[1105]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[795]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[1106]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1104]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[1106]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1104]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1104]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[907]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[907]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[907]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[809]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[29]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[609]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[611]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1109]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[617]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[619]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[1111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[512]

Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[226]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[252]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]

Drug(s) Affected By 26S proteasome complex subunit SEM1 (SEM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[233]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[1115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[249]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1116]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[1117]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[1118]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1120]
Bortezomib	DMNO38U	Leukemia		Approved	[705]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[437]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[585]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[486]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[863]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1121]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[516]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1120]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1124]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[1125]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[230]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[253]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[253]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[1127]

Drug(s) Affected By Fractalkine (CX3CL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[374]
Fructose	DM43AN2	Vomiting	MD90	Approved	[463]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[374]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[859]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[1130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By ADP-ribosylation factor 1 (ARF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1010]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[1133]

Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[1136]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1137]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[253]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[1138]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[253]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[1139]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[870]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[249]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[1140]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[822]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1141]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[1142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Interleukin-5 receptor subunit alpha (IL5RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1143]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[1144]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[1145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1147]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1096]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[1147]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[653]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Indomethacin	DMSC4A7	Bursitis		Approved	[936]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[991]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[674]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1149]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1072]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[757]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1153]

Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[873]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1156]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[1157]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1157]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1157]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1059]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[1158]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1159]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[496]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1160]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[1161]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[957]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1162]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[862]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1165]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[1166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[1167]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1168]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[1169]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1170]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1171]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1173]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1175]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[996]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[434]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[412]

Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1126]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1176]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[240]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]

Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[367]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1047]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[367]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[367]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[859]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1177]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[582]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1178]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[183]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[333]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[491]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[253]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[822]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1184]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1185]

Drug(s) Affected By Prolow-density lipoprotein receptor-related protein 1 (LRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[1186]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1187]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[251]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[225]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1188]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[1100]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Tyrosine-protein kinase Mer (MERTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[130]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1191]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[852]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[1101]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1192]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1101]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1193]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[1102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1194]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1195]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[421]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1196]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[486]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1198]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[1199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1200]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1201]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[322]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1202]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[909]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1201]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[322]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1203]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[1204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1205]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[909]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[1206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1207]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1208]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[474]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[776]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1209]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1210]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[662]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[432]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[758]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[726]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[779]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[552]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1212]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[345]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[992]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[74]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[1213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[249]

Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[1214]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[896]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[195]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1216]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1018]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[867]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]
Bortezomib	DMNO38U	Leukemia		Approved	[1219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[1220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1219]

Drug(s) Affected By Telomeric repeat-binding factor 2 (TERF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[240]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1223]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[201]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1225]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[733]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[390]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[831]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[572]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1226]

Drug(s) Affected By Transcription factor E2F4 (E2F4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1227]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1230]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[571]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[585]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[200]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1072]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1233]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1234]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1235]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1236]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[982]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[420]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[412]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[1240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1241]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1242]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1243]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1245]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1246]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1246]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1248]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[115]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[926]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[907]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1250]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[907]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[792]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[907]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF187 (RNF187)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[32]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[249]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[1251]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[1251]
H-89	DM4RVGO	Discovery agent	N.A.	Investigative	[1251]

Drug(s) Affected By Matrix metalloproteinase-21 (MMP21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[988]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[556]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[424]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1254]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[1255]

Drug(s) Affected By Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1256]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1257]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[991]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1258]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1259]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1261]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[607]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1262]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[725]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[254]

Drug(s) Affected By Interleukin-12 receptor subunit beta-2 (IL12RB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[668]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1067]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[1067]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]

Drug(s) Affected By Zinc finger protein Gfi-1 (GFI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[1265]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[143]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1266]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1267]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1269]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[863]

Drug(s) Affected By Coronin-1B (CORO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[125]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[870]

Drug(s) Affected By Immediate early response gene 2 protein (IER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1270]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[429]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[255]

Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1090]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1090]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1271]

Drug(s) Affected By NF-kappa-B inhibitor zeta (NFKBIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[431]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[357]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1256]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Serine/threonine-protein kinase D2 (PRKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[391]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[799]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1272]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[197]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[360]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1063]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1273]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1274]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1275]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1276]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1066]

Drug(s) Affected By G-protein coupled receptor 84 (GPR84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[250]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[702]

Drug(s) Affected By Protection of telomeres protein 1 (POT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[155]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[408]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[428]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[411]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[345]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[345]

Drug(s) Affected By Potassium voltage-gated channel subfamily D member 3 (KCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1277]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[232]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[260]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1279]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Endothelial protein C receptor (PROCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1280]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[454]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[156]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[58]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[454]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[69]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[420]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[72]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[367]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[713]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[629]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[798]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[745]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1283]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[160]

Drug(s) Affected By Protein delta homolog 1 (DLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[873]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1284]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[159]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Indomethacin	DMSC4A7	Bursitis		Approved	[1285]

Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[34]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[1286]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1287]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[61]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1289]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-activated potassium channel KCa4.1 (KCNT1)	TTGJFK1	KCNT1_HUMAN	Activator	[2]
Calcium-activated potassium channel KCa4.2 (KCNT2)	TTLU5FO	KCNT2_HUMAN	Inhibitor (gating inhibitor)	[2]
Inward rectifier potassium channel Kir3.4 (KCNJ5)	TTEO25X	KCNJ5_HUMAN	Inhibitor (gating inhibitor)	[3]
Transient receptor potential cation channel V4 (TRPV4)	TTKP2SU	TRPV4_HUMAN	Activator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Protein Interaction/Cellular Processes	[5]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[6]
26S proteasome complex subunit SEM1 (SEM1)	OTASLBM1	SEM1_HUMAN	Gene/Protein Processing	[7]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[8]
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Gene/Protein Processing	[9]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[10]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Protein Interaction/Cellular Processes	[11]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Protein Interaction/Cellular Processes	[11]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[12]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[13]

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