Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJWD62)

• Drug Name: phorbol 12-myristate 13-acetate Drug Info
• Synonyms: TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 2	[1]
Hodgkin lymphoma	2B30	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 27924
  ChEBI ID: CHEMBL279115
  CAS Number: CAS 16561-29-8
  TTD Drug ID: DMJWD62

Molecule-Related Drug Atlas

Drug(s) Targeting Calcium-activated potassium channel KCa4.1 (KCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[15]
iberiotoxin	DMRIG3O	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Transient receptor potential cation channel V4 (TRPV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GSK2798745	DM7V96W	Heart failure	BD10-BD13	Phase 2	[17]
citric acid	DM80YI7	Discovery agent	N.A.	Investigative	[18]
4-Pyridin-2-yl-piperazine-1-carboxylic acid amide	DMFC8Q4	Discovery agent	N.A.	Investigative	[19]
Pyrrolidin-1-yl-thiourea	DMYNZXC	Discovery agent	N.A.	Investigative	[19]
CAPSAZEPINE	DM4ATCI	Discovery agent	N.A.	Investigative	[20]
SC-0030	DMD2WEQ	Discovery agent	N.A.	Investigative	[21]
bisandrographolide	DMRSKGC	Discovery agent	N.A.	Investigative	[22]
GSK1016790A	DMDHZR1	Discovery agent	N.A.	Investigative	[23]
GSK2193874	DMY2XV3	Discovery agent	N.A.	Investigative	[24]
RN1734	DMA3ZXM	Discovery agent	N.A.	Investigative	[25]

Drug(s) Targeting Calcium-activated potassium channel KCa4.2 (KCNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[2]
iberiotoxin	DMRIG3O	Discovery agent	N.A.	Investigative	[26]

Drug(s) Targeting Inward rectifier potassium channel Kir3.4 (KCNJ5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PIP2	DMOZV7N	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[35]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[47]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[48]
Methysergide	DM1EF73	Migraine	8A80	Approved	[49]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[54]

Drug(s) Affected By Cornifin-B (SPRR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[57]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[57]

Drug(s) Affected By Cornifin-A (SPRR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[69]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By Erythroid transcription factor (GATA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[74]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[76]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[77]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[78]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Cytochrome b5 (CYB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[91]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[98]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By Serine/threonine-protein kinase PAK 3 (PAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[108]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[106]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Bortezomib	DMNO38U	Leukemia		Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By M-phase inducer phosphatase 2 (CDC25B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[123]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[46]

Drug(s) Affected By Replication factor C subunit 4 (RFC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[128]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[65]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[130]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[85]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[143]

Drug(s) Affected By Cryptochrome-1 (CRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Haloperidol	DM96SE0	Delirium		Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[150]

Drug(s) Affected By Dual specificity protein phosphatase 13A (DUSP13B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[39]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By General transcription factor IIH subunit 4 (GTF2H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[156]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[156]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[128]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[159]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]

Drug(s) Affected By Sperm-associated antigen 5 (SPAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Mestranol	DMG3F94	Contraception	QA21	Approved	[163]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By DNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[168]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[174]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[175]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[177]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[178]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[179]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[179]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[187]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[190]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[12]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[194]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[194]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[203]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[193]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[193]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[12]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[12]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[139]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[143]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[208]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[218]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[227]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[231]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[234]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[233]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[235]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[240]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[241]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[250]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[251]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[252]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[256]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[259]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[260]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[260]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[266]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[267]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[269]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[270]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[271]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]

Drug(s) Affected By Interleukin-2 receptor subunit alpha (IL2RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[274]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[275]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[276]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[278]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[279]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[281]

Drug(s) Affected By Fibrinogen gamma chain (FGG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[282]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[283]

Drug(s) Affected By Glycophorin-A (GYPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[284]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[285]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[286]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[287]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[253]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[288]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[289]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[290]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[253]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[291]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[292]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[293]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[294]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[295]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[296]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]

Drug(s) Affected By Platelet basic protein (PPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[299]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[300]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[301]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[237]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[303]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[304]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[309]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[310]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[311]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[312]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[315]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[318]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[321]
Selenium	DM25CGV	N. A.	N. A.	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[323]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[324]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[329]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[330]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[261]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[331]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[334]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[339]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[41]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[340]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[340]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[341]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[240]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[341]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[341]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[350]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[351]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[353]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[354]
Fructose	DM43AN2	Vomiting	MD90	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[358]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[361]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[362]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[271]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[240]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[371]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[372]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Platelet glycoprotein Ib alpha chain (GP1BA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[373]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[375]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[376]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[377]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[377]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[378]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[379]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[157]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[380]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[381]
Terbutaline	DMD4381	Asthma	CA23	Approved	[382]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[383]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[386]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[387]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[253]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[253]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[319]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[390]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[391]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[390]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[82]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[391]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[392]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[393]
Abciximab	DMJO6GV	Acute disease		Approved	[253]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[253]

Drug(s) Affected By Pleckstrin (PLEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[394]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[395]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[396]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[397]
5'-Guanosine-Diphosphate-Monothiophosphate	DMIARG7	Discovery agent	N.A.	Investigative	[398]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[399]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[399]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[400]
Methamphetamine	DMPM4SK	Anxiety		Approved	[401]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[402]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[402]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[403]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[8]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[404]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[407]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[408]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[409]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[410]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[411]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[412]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[411]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[413]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[414]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[416]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[417]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[418]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[419]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[342]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[422]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[420]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[394]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[423]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[424]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[427]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[428]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[429]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[430]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[431]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[432]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[406]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[433]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[434]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[436]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[437]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[438]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[439]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[440]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[441]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[442]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[443]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[443]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[444]
Selenium	DM25CGV	N. A.	N. A.	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[445]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[446]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[447]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[448]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[449]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[450]

Drug(s) Affected By Transcription factor PU.1 (SPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[452]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[453]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[454]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[75]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[458]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[459]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[460]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[183]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[461]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[462]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[463]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[464]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[394]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[208]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[468]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[469]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[450]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[472]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[473]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[476]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[159]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[468]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[477]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[477]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[478]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[480]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[481]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[480]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[482]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[483]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[480]

Drug(s) Affected By Macrophage scavenger receptor types I and II (MSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[405]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[484]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[485]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[486]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[487]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[488]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[394]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 4 (FUT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[489]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[491]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[375]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[492]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[493]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[470]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[494]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[495]

Drug(s) Affected By Protein kinase C eta type (PRKCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[496]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Indomethacin	DMSC4A7	Bursitis		Approved	[497]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[339]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[208]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[500]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[502]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[503]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[504]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[505]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[506]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[507]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[508]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[509]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[500]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[510]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[511]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[512]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[502]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[503]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[513]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[513]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[514]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[105]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[236]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[515]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[516]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[188]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[478]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[517]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[518]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[519]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[520]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[521]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[522]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[524]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[525]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[390]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[526]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[527]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[528]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[526]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[529]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[530]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[531]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[532]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[450]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[533]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]

Drug(s) Affected By Neurotensin/neuromedin N (NTS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[534]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[535]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[520]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[536]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[537]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[538]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[535]

Drug(s) Affected By Syndecan-4 (SDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[540]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[541]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[228]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[394]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[514]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[542]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[543]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[544]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[545]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[546]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[547]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[339]

Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[549]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[550]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[551]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[552]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[553]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[552]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[554]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[555]

Drug(s) Affected By Macrosialin (CD68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[556]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[406]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[406]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]

Drug(s) Affected By Mu-type opioid receptor (OPRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alvimopan	DMHR8KW	Gastrointestinal disease	DE2Z	Approved	[557]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[558]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[559]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[560]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[561]
Oliceridine	DM6MDCF	Acute pain	MG31	Approved	[558]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[562]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[563]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[564]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[357]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[89]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[565]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[412]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[95]

Drug(s) Affected By L-dopachrome tautomerase (DCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[484]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[566]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[566]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[537]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[567]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[537]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[253]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[568]

Drug(s) Affected By Interleukin-12 receptor subunit beta-1 (IL12RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[569]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[392]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[569]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[570]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[262]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[154]
Dimethylallyl Diphosphate	DMP5I47	Discovery agent	N.A.	Investigative	[571]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[572]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[573]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[321]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[574]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[575]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[358]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[576]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[358]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[577]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[578]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[580]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[361]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[529]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[565]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[577]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[581]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[582]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[583]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[584]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[585]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[587]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]

Drug(s) Affected By Serpin B9 (SERPINB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[57]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[105]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[463]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Calponin-1 (CNN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[155]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[151]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[527]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[589]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[590]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[480]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[480]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[442]

Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[591]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[592]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[593]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[131]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[156]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]

Drug(s) Affected By 26S proteasome complex subunit SEM1 (SEM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[594]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[596]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[597]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[598]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[599]
Bortezomib	DMNO38U	Leukemia		Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[354]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[600]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[600]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[599]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[601]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[602]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[603]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[135]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[157]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[157]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[604]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[605]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[479]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[606]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[607]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[608]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[609]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[610]
Selenium	DM25CGV	N. A.	N. A.	Approved	[611]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[157]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[612]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[613]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[157]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[614]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[157]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[615]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[5]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[616]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[481]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[240]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[617]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[618]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Interleukin-5 receptor subunit alpha (IL5RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[619]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[620]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[621]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[622]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[623]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[474]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[625]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[626]

Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[628]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[629]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[630]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[631]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[631]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[631]

Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[632]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[633]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[541]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[634]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[635]

Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[636]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[603]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[637]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[638]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[639]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[640]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[641]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[642]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[466]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[643]

Drug(s) Affected By Prolow-density lipoprotein receptor-related protein 1 (LRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[644]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[645]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[155]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[253]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[646]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[647]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[214]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[648]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[649]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[650]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[651]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[652]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[653]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[654]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[587]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[655]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[483]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[653]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[654]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[656]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[657]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[658]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[483]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[659]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[660]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[392]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[537]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[41]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[661]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]

Drug(s) Affected By Serine/threonine-protein kinase D1 (PRKD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[392]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[662]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[663]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[664]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[105]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[665]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[666]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[554]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[667]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Bortezomib	DMNO38U	Leukemia		Approved	[668]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[669]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[670]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[671]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[668]

Drug(s) Affected By Transcription factor E2F4 (E2F4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[672]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[673]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[674]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[675]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[333]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[335]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[676]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[110]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[576]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[677]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[678]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[679]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[680]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[681]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[682]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[683]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[684]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[685]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[686]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[480]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[431]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[480]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF187 (RNF187)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[484]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[153]
PMID28460551-Compound-3	DMA1FRM	N. A.	N. A.	Patented	[687]
U0126	DM31OGF	Discovery agent	N.A.	Investigative	[687]
H-89	DM4RVGO	Discovery agent	N.A.	Investigative	[687]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[688]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[689]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[234]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[690]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[691]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Selenium	DM25CGV	N. A.	N. A.	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[692]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[693]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[694]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[695]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[696]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[341]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[697]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Interleukin-12 receptor subunit beta-2 (IL12RB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[463]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[698]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[699]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[569]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[569]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[61]

Drug(s) Affected By Zinc finger protein Gfi-1 (GFI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[700]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[701]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[490]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[702]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[703]

Drug(s) Affected By Coronin-1B (CORO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[65]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[37]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]

Drug(s) Affected By Immediate early response gene 2 protein (IER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[704]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[240]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[159]

Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 1 (MKNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[705]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[705]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[706]

Drug(s) Affected By NF-kappa-B inhibitor zeta (NFKBIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[242]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[202]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[172]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[707]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Drug(s) Affected By Serine/threonine-protein kinase D2 (PRKD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[708]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[709]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[107]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[710]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[711]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[712]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[220]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[713]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[714]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[715]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[716]

Drug(s) Affected By G-protein coupled receptor 84 (GPR84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[717]

Drug(s) Affected By Protection of telomeres protein 1 (POT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[220]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[239]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[237]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[193]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[193]

Drug(s) Affected By Potassium voltage-gated channel subfamily D member 3 (KCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[718]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[719]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[720]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Endothelial protein C receptor (PROCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[721]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Calcium-activated potassium channel KCa4.1 (KCNT1)	TTGJFK1	KCNT1_HUMAN	Activator	[2]
Calcium-activated potassium channel KCa4.2 (KCNT2)	TTLU5FO	KCNT2_HUMAN	Inhibitor (gating inhibitor)	[2]
Inward rectifier potassium channel Kir3.4 (KCNJ5)	TTEO25X	KCNJ5_HUMAN	Inhibitor (gating inhibitor)	[3]
Transient receptor potential cation channel V4 (TRPV4)	TTKP2SU	TRPV4_HUMAN	Activator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Protein Interaction/Cellular Processes	[5]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[6]
26S proteasome complex subunit SEM1 (SEM1)	OTASLBM1	SEM1_HUMAN	Gene/Protein Processing	[7]
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Gene/Protein Processing	[8]
ADP-ribosylation factor 6 (ARF6)	OTVV7KJO	ARF6_HUMAN	Protein Interaction/Cellular Processes	[9]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[10]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[11]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[12]
Alpha-(1,3)-fucosyltransferase 4 (FUT4)	OTIBXRTL	FUT4_HUMAN	Gene/Protein Processing	[13]
Amyloid beta precursor like protein 2 (APLP2)	OTTFE53M	APLP2_HUMAN	Protein Interaction/Cellular Processes	[14]

References

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