Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMG2TO)

• Drug Name: D-glucose Drug Info
• Synonyms: D-Glucopyranose; Glucopyranose; D-Glc; D-Glcp; Glucodin; Meritose; Clintose L; Roferose ST; CPC hydrate; Clearsweet 95; 2280-44-6; Staleydex 95M; CHEBI:4167; Glucopyranoside; D-Glucopyranoside; Glc; (3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; Glucopyranose, D-; DSSTox_CID_2910; Glucose solution; D-Glucopyranose, anhydrous; glc-ring; D-glucose-ring; Cartose Cerelose; Staleydex 130; Glucose 40; EINECS 218-914-5; Meritose 200; Glc-OH

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5793
  ChEBI ID: CHEBI:4167
  CAS Number: CAS 2280-44-6
  TTD Drug ID: DMMG2TO
  VARIDT Drug ID: DR00165
  INTEDE Drug ID: DR2081

Molecule-Related Drug Atlas

Drug(s) Transported By Glucose transporter type 1, erythrocyte/brain (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
dehydroascorbic acid	DMKYQO4	Discovery agent	N.A.	Investigative	[21]
Arsenite	DMBCO4Q	Discovery agent	N.A.	Investigative	[22]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[33]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Fructose	DM43AN2	Vomiting	MD90	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]

Drug(s) Affected By Nitric oxide synthase 1 (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[63]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[65]
Bortezomib	DMNO38U	Leukemia		Approved	[66]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[67]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[71]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[73]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[74]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[97]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[98]
Fructose	DM43AN2	Vomiting	MD90	Approved	[43]
Ketoprofen	DMRKXPT	Bursitis		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[100]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[101]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[102]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[108]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[111]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[112]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[113]

Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[116]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[117]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[118]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[119]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[119]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[124]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[125]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[59]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[59]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[127]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[141]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[142]

Drug(s) Affected By Bone morphogenetic protein 2 (BMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By Gap junction alpha-1 protein (GJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[156]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[153]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[158]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[159]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[160]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[161]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[166]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[168]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[173]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[176]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[177]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[178]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[179]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[180]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[182]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[184]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[185]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[186]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[190]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[191]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[108]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Selenium	DM25CGV	N. A.	N. A.	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]

Drug(s) Affected By Small ribosomal subunit protein uS2 (RPSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[212]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[213]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[217]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By Small ribosomal subunit protein eS12 (RPS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[220]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[221]
Myricetin	DMTV4L0	Discovery agent	N.A.	Investigative	[222]
(E)-4-(3,5-dimethoxystyryl)phenol	DMYXI2V	Discovery agent	N.A.	Investigative	[223]

Drug(s) Affected By Proteasome subunit alpha type-1 (PSMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[225]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[226]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[227]

Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[231]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]

Drug(s) Affected By Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]

Drug(s) Affected By Alpha-soluble NSF attachment protein (NAPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[236]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[239]

Drug(s) Affected By Protein SEC13 homolog (SEC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[243]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[245]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[245]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[248]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[245]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[245]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[245]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[250]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[251]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[252]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[253]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[254]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[255]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[256]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[257]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[258]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[259]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[257]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Indomethacin	DMSC4A7	Bursitis		Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[93]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[264]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[265]
Haloperidol	DM96SE0	Delirium		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Selenium	DM25CGV	N. A.	N. A.	Approved	[267]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[268]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[273]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[277]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[282]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[281]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 7 (TRPM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[285]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[287]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[288]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[289]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[290]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[290]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[292]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[293]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]

Drug(s) Affected By Hemoglobin subunit alpha (HBA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[297]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[298]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[299]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[300]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[301]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[303]
Ketoprofen	DMRKXPT	Bursitis		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]

Drug(s) Affected By Band 3 anion transport protein (SLC4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Adefovir	DMM278X	N. A.	N. A.	Approved	[43]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[309]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[310]
AMG 386	DMQJXL4	Breast cancer	2C60-2C65	Phase 3	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
Selenious acid	DMB7GPA	N. A.	N. A.	Investigative	[313]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[320]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[323]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[324]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[298]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[301]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[325]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[329]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[217]

Drug(s) Affected By Copper transport protein ATOX1 (ATOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[330]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[331]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[336]

Drug(s) Affected By ATP-dependent RNA helicase DDX3X (DDX3X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[342]

Drug(s) Affected By Acetyl-CoA carboxylase 2 (ACACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[297]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[345]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[346]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[349]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[350]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[352]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[353]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[355]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Calumenin (CALU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]

Drug(s) Affected By Dynamin-like 120 kDa protein, mitochondrial (OPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[334]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[335]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]

Drug(s) Affected By TBC1 domain family member 4 (TBC1D4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[360]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[361]

Drug(s) Affected By Nephrin (NPHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[364]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[365]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[367]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[365]
Puromycin	DMDKLB5	N. A.	N. A.	Preclinical	[368]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[371]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[326]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[375]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[376]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[377]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[374]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[381]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[382]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[383]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[384]

Drug(s) Affected By Cytochrome b (CYTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[386]
Fialuridine	DMCIGRB	Hepatitis B virus infection	1E51.0	Phase 2	[387]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[388]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[389]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[390]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[43]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[393]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[394]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]

Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[229]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[397]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[397]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[399]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[400]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[401]
Haloperidol	DM96SE0	Delirium		Approved	[43]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[403]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[404]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[406]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[410]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]

Drug(s) Affected By Complement C1r subcomponent (C1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[412]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[414]

Drug(s) Affected By Haptoglobin (HP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[415]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[416]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[417]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[418]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[95]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[420]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[421]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[423]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[424]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[425]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[427]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[428]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[430]
Selenium	DM25CGV	N. A.	N. A.	Approved	[431]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[432]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[434]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[437]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[168]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[438]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]

Drug(s) Affected By Protransforming growth factor alpha (TGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[441]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[442]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[443]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[444]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[445]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[446]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[447]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[448]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]

Drug(s) Affected By Beta-nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[449]
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[450]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[451]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[452]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[453]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]

Drug(s) Affected By Calcitonin (CALCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[454]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[455]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[297]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[454]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[456]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[457]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[459]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[460]
Fructose	DM43AN2	Vomiting	MD90	Approved	[461]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[462]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[463]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[464]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[465]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[466]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[468]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[469]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[470]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[471]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[474]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[475]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[476]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[477]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[478]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[479]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[480]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[481]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[482]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[484]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[485]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[486]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[487]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[488]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[43]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[489]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[490]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[491]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[492]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[493]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[494]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[495]

Drug(s) Affected By Platelet factor 4 (PF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[496]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[497]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[498]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[498]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[500]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[501]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[502]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[505]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[506]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[508]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[505]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[510]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[511]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[512]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[514]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[515]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[516]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[517]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[518]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fructose	DM43AN2	Vomiting	MD90	Approved	[519]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[520]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[521]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[522]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[521]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[521]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[521]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[523]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[524]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[526]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[527]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[528]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[529]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[530]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[531]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[533]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[534]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[535]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[35]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[536]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[536]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[537]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[538]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[539]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[541]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[542]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[543]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[545]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[117]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[548]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[549]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[550]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[553]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[554]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[43]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[555]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[556]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[557]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[558]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[559]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[560]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[561]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[562]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[376]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[563]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[565]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[547]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[202]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[566]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[567]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[110]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[415]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[568]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[569]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[570]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[571]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[572]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[573]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[574]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[575]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[575]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[429]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[576]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[577]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[578]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[579]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[580]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[581]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[582]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[583]
Fructose	DM43AN2	Vomiting	MD90	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[190]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[585]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[586]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[587]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[588]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[589]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[591]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[593]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[594]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[595]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[212]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[596]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[455]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[597]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[598]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[599]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[600]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[438]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[601]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[602]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[603]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[604]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[605]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[606]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[607]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[608]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[609]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[217]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[610]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[611]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[613]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[612]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[612]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[612]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[614]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[615]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[616]
Selenium	DM25CGV	N. A.	N. A.	Approved	[617]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[618]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[619]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[620]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[621]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[622]

Drug(s) Affected By Thrombomodulin (THBD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[623]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[625]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[626]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[627]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[628]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[629]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[626]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[630]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[631]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[628]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[632]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[633]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[202]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[634]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[635]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[637]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[638]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[480]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[329]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]

Drug(s) Affected By Zinc finger protein GLI1 (GLI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[639]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[641]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[455]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[642]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[643]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[644]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[612]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[645]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[614]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[612]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[412]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[646]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[647]

Drug(s) Affected By Annexin A5 (ANXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[648]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[649]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[650]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[468]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[651]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[652]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[653]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[654]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[655]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[462]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[656]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[657]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[658]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[659]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[660]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Selenium	DM25CGV	N. A.	N. A.	Approved	[661]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[581]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[662]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]

Drug(s) Affected By Complement C1s subcomponent (C1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[412]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[664]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[666]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[667]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[668]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[667]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[669]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[670]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[671]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[672]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[673]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[674]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[675]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[676]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[677]

Drug(s) Affected By Zinc finger protein GLI2 (GLI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[639]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[214]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[678]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[679]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[680]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[681]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[682]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[683]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[100]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[163]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[685]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[686]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[687]

Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[688]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[688]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[689]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[690]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[691]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[650]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[692]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[455]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[694]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[374]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[695]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[696]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[697]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[315]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[698]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[699]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[700]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[701]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[702]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[703]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[704]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[705]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[706]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[707]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[708]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[709]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[417]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[593]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[710]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[711]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]

Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[542]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[142]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[547]

Drug(s) Affected By Collagen alpha-2(VI) chain (COL6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[542]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[712]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[142]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[713]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[523]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[43]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[43]
Quinapril	DMR8H31	Chronic heart failure	BD1Z	Approved	[43]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[714]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[715]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[716]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[717]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[718]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[719]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[720]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[721]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[589]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]

Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[722]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[723]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[724]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[725]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[726]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[43]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[727]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[728]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[729]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[567]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[730]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[445]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[731]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[581]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[732]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[733]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[734]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[735]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[736]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[737]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[738]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[739]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[740]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[741]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[742]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[743]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[744]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[745]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[746]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[741]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]

Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Haloperidol	DM96SE0	Delirium		Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[747]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[748]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[749]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[750]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[751]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[752]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[753]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[583]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[754]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[755]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[756]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[757]
Fructose	DM43AN2	Vomiting	MD90	Approved	[70]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[343]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Haloperidol	DM96SE0	Delirium		Approved	[758]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[759]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[760]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[761]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Selenium	DM25CGV	N. A.	N. A.	Approved	[431]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[762]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[669]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[763]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[764]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[765]

Drug(s) Affected By Folate receptor alpha (FOLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[766]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[767]
Bortezomib	DMNO38U	Leukemia		Approved	[768]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[769]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[414]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[770]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[771]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[772]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[773]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[774]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[775]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[486]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[776]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]

Drug(s) Affected By Atrial natriuretic peptide receptor 1 (NPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[645]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[712]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[777]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[43]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[778]

Drug(s) Affected By Beta-galactosidase (GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[779]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[780]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[781]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[130]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[497]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[782]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[478]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[784]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[785]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[786]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[787]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[788]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[789]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[790]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[791]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[792]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[793]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[794]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[795]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[796]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[374]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[797]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[798]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[799]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[800]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[801]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[785]

Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[802]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[803]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[804]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[805]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[523]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[806]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[807]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[808]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Haloperidol	DM96SE0	Delirium		Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[809]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[810]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[811]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[810]
Bortezomib	DMNO38U	Leukemia		Approved	[812]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[810]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[810]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[813]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[376]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[563]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[814]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[815]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[329]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[816]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[817]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[818]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[702]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[819]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[758]
Methamphetamine	DMPM4SK	Anxiety		Approved	[820]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[821]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[822]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[823]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[824]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[825]
Haloperidol	DM96SE0	Delirium		Approved	[26]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[43]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[826]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[827]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[43]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[43]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[43]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[828]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[802]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[828]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[828]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[829]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[830]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[831]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[600]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[710]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[168]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[832]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[833]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[834]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[798]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[835]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[835]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Zinc-alpha-2-glycoprotein (AZGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[836]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[837]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[838]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[839]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[837]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[666]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[840]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[841]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[842]

Drug(s) Affected By Metallothionein-3 (MT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[823]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[843]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[844]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[845]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[846]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[847]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[43]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[848]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[849]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[850]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[851]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[852]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[853]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[854]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[855]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[856]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[857]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[858]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[859]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[860]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[861]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[862]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[100]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[863]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[864]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[865]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[866]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[867]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]

Drug(s) Affected By Proteasome subunit beta type-5 (PSMB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[868]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[869]
Bortezomib	DMNO38U	Leukemia		Approved	[870]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[871]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[32]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[871]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[872]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[873]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[861]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[874]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[875]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[876]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[860]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[100]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[863]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[877]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[531]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[878]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[202]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[879]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]

Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[880]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Bortezomib	DMNO38U	Leukemia		Approved	[370]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[881]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[882]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[110]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[580]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[883]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[884]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]

Drug(s) Affected By Type-1 angiotensin II receptor (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[886]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[887]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[656]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]

Drug(s) Affected By Pyruvate kinase PKLR (PKLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[264]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[888]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[889]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[817]

Drug(s) Affected By Sorcin (SRI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[890]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[340]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[891]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]

Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[892]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[893]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[686]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[894]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[895]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[896]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[897]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[898]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[899]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[900]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[901]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[902]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[903]

Drug(s) Affected By Pulmonary surfactant-associated protein D (SFTPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[904]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[478]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[905]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[906]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[907]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[908]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[822]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[909]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[910]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[911]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[912]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[913]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[914]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[915]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[916]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[913]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[914]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[917]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[889]

Drug(s) Affected By Transcription factor SOX-6 (SOX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[36]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[367]

Drug(s) Affected By Keratin, type I cytoskeletal 20 (KRT20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[918]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[919]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[920]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[367]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[921]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[782]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[922]
Haloperidol	DM96SE0	Delirium		Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[923]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[442]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[925]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[835]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[835]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Pigment epithelium-derived factor (SERPINF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[926]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[926]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[455]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[43]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[927]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[305]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[928]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[929]

Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[617]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[930]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[931]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[844]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[932]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[468]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[588]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[604]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[590]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[933]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[844]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[213]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[934]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[650]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[935]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[600]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[936]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[273]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[668]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[937]

Drug(s) Affected By Protein Mpv17 (MPV17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[386]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[938]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[909]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[939]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[940]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[941]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[942]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[943]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[944]

Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[26]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[567]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[945]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[946]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[947]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[567]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[567]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[948]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[949]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[950]

Drug(s) Affected By Prostaglandin-H2 D-isomerase (PTGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[951]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]

Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[952]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Fructose	DM43AN2	Vomiting	MD90	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[953]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[687]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[954]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[889]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[955]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[956]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[957]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[442]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[958]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[959]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[960]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[168]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[961]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[962]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[815]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[963]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[964]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[965]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[526]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[966]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[967]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[968]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[969]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[970]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[848]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[620]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[971]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[217]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[972]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[584]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[586]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[55]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[973]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[586]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[974]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[598]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[831]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[975]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[976]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[977]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[978]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[979]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[980]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[981]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[982]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[841]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[983]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[984]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[985]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[986]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[189]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[987]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[879]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[988]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[989]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[990]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[991]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[633]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[992]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[599]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[993]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[994]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[995]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[996]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[377]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[431]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[997]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[998]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[999]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[1000]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1001]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1002]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[1003]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1004]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1005]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[763]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1006]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[686]

Drug(s) Affected By Pancreas/duodenum homeobox protein 1 (PDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[1007]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1008]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1009]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1010]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[1011]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[1012]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1013]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1014]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[1015]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1016]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[1017]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[683]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1018]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[666]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1019]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1020]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1021]

Drug(s) Affected By Gasdermin-D (GSDMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[658]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[1022]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[658]
Ropivacaine	DMSPJG2	Anaesthesia	9A78.6	Approved	[1023]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1024]

Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1025]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1026]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[596]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[494]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[1027]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1028]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[1029]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1030]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[531]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1031]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[193]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1031]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1032]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1033]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[645]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[768]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1034]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1035]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[533]

Drug(s) Affected By Fractalkine (CX3CL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Fructose	DM43AN2	Vomiting	MD90	Approved	[409]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[836]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1036]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[803]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[1037]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1038]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1039]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]

Drug(s) Affected By Protein S100-A12 (S100A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[763]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[605]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[501]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Miglitol	DMXBQAM	Diabetic complication	5A2Y	Approved	[1040]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[1041]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[1042]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1043]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1044]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1045]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[359]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1046]

Drug(s) Affected By RNA-binding protein 3 (RBM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[690]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1047]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1048]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[664]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1018]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[695]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1049]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1050]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1051]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1052]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1053]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[1054]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[1055]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1056]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1057]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[1058]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1058]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1059]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1060]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[1058]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[1058]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1058]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1058]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1061]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1062]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[879]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1063]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[880]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1064]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[613]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[612]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[612]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[612]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1065]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[613]

Drug(s) Affected By Angiopoietin-1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[835]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[835]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1066]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1067]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[1068]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[361]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[163]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[866]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1069]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1070]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[611]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1071]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1072]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1073]

Drug(s) Affected By Lactoylglutathione lyase (GLO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1074]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[864]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1075]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1076]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1077]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1078]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1079]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[1080]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[1081]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1082]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1083]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1084]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1085]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1086]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[488]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1087]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1088]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[895]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[678]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[848]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[682]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[59]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1018]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[600]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1089]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[668]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[728]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1090]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[176]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1091]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1092]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1093]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[852]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1094]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[903]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1095]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[803]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1096]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1097]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[992]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[1098]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[991]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[1099]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[1100]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1101]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[1102]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[1102]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[1103]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1104]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1105]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[1106]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[1102]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[958]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[992]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[343]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1107]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[562]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[1108]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1109]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1108]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1110]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[889]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1111]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[611]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1045]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[442]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[958]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[645]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[883]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[467]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[925]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[1117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[210]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[659]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[210]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1119]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[883]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1120]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[645]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[891]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1121]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1123]

Drug(s) Affected By Eukaryotic translation initiation factor 4H (EIF4H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[361]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[1125]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[337]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[221]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[338]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1126]
Ciprofibrate	DMGC5DB	Hyperlipoproteinemia	5C80	Approved	[1127]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1128]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[15]

Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[611]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[925]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[210]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[567]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[567]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[1129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[912]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[567]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[1130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1131]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[567]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[948]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1132]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[660]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[1133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[774]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1134]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1135]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[531]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[974]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1136]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1137]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[1141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1088]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1143]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1144]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1146]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1148]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1149]

Drug(s) Affected By Diacylglycerol kinase delta (DGKD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1150]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[237]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[645]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[883]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[825]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1151]

Drug(s) Affected By 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]

Drug(s) Affected By F-box/WD repeat-containing protein 12 (FBXW12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[149]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[335]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1152]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[340]
Bortezomib	DMNO38U	Leukemia		Approved	[768]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (PREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1154]

Drug(s) Affected By Cytoglobin (CYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]

Drug(s) Affected By Interactor protein for cytohesin exchange factors 1 (IPCEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[125]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[1157]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[237]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[125]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[1157]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[1158]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[763]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[702]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[68]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1160]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1161]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[1162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1163]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1165]
Mestranol	DMG3F94	Contraception	QA21	Approved	[1166]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[1167]

Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[554]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[302]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Bortezomib	DMNO38U	Leukemia		Approved	[812]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1171]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 2 (PNPLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1014]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1047]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[386]
Beta-caryophyllene	DM7583A	Pain	MG30-MG3Z	Phase 2	[1172]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[1173]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1175]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[280]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[645]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1176]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1177]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1178]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[1180]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1116]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[329]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1182]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[117]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1119]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[1183]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1185]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[1183]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[1184]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Bifunctional polynucleotide phosphatase/kinase (PNKP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1189]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[1190]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[1192]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1194]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1195]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1197]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[958]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[960]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1198]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1200]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[815]

Drug(s) Affected By Mitochondrial fission factor (MFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[388]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[1125]

Drug(s) Affected By Forkhead box protein P1 (FOXP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]

Drug(s) Affected By MLX-interacting protein (MLXIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1203]

Drug(s) Affected By NADPH oxidase 4 (NOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[727]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1205]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[134]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[889]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1206]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[666]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1207]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]

Drug(s) Affected By Dual oxidase 2 (DUOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[823]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[817]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[533]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[1209]

Drug(s) Affected By Dual oxidase 1 (DUOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1210]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1010]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1211]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[1212]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[1213]

Drug(s) Affected By Fibroblast growth factor 21 (FGF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1214]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1215]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1215]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1216]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[1217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[1217]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[1214]

Drug(s) Affected By Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[777]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[386]

Drug(s) Affected By Probable tRNA(His) guanylyltransferase (THG1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[749]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[1042]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[374]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1218]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[374]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[376]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[377]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1219]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1220]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[1221]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[1223]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[487]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[901]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[611]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[1225]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[533]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[884]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[752]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[64]

Drug(s) Affected By Transcription factor 19 (TCF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[852]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[624]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[412]

Drug(s) Affected By Insulin receptor substrate 2 (IRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[392]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[522]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1228]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]

Drug(s) Affected By Sodium/glucose cotransporter 1 (SLC5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[771]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[693]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[817]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[366]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[1229]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1230]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[1231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[612]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[614]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[613]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[612]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[612]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[612]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[614]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1232]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]

Drug(s) Affected By Pyruvate carboxylase, mitochondrial (PC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1096]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[235]

Drug(s) Affected By Ras GTPase-activating protein-binding protein 1 (G3BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1035]

Drug(s) Affected By L-lactate dehydrogenase B chain (LDHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[825]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[134]

Drug(s) Affected By Hepatocyte nuclear factor 1-alpha (HNF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1235]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[596]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1237]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[1238]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[596]

Drug(s) Affected By NAD(P) transhydrogenase, mitochondrial (NNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[26]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[339]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1239]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1239]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[417]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]
Fructose	DM43AN2	Vomiting	MD90	Approved	[1240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[386]

Drug(s) Affected By Potassium voltage-gated channel subfamily D member 2 (KCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1242]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[533]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[1243]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[1244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[547]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1246]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1247]

Drug(s) Affected By Retinol-binding protein 4 (RBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[951]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[951]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[120]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[544]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[883]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[523]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[394]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[395]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[39]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Fructose	DM43AN2	Vomiting	MD90	Approved	[1240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[1003]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[645]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[376]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[377]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1249]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 7 (SLC2A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[1250]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1251]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[1252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1253]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[85]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1254]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1255]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[917]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]

Drug(s) Affected By Resistin (RETN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[620]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1256]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[950]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1257]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1258]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[1259]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1260]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[1261]
Icosapentum	DMF1CM7	N. A.	N. A.	Investigative	[1262]

Drug(s) Affected By Glycogen debranching enzyme (AGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[84]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1263]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[211]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[230]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium/glucose cotransporter 2 (SLC5A2)	DTKNH2D	SC5A2_HUMAN	Substrate	[2]
Glucose transporter type 1, erythrocyte/brain (SLC2A1)	DTG3T6X	GTR1_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
ADP-dependent glucokinase (ADPGK)	DENZGO4	ADPGK_HUMAN	Substrate	[4]
Brain form hexokinase (HK1)	DEDMAGE	HXK1_HUMAN	Substrate	[5]
Alcohol dehydrogenase (ADH)	DEKU5HL	A4L2V0_LACRE	Substrate	[6] , [7]
D-Lactate dehydrogenase (ldhA)	DEQUGC0	A0A1C7BXR3_PSEAI	Substrate	[8] , [9]
Alpha-glucosidase (aglA)	DEAMSKV	PAGL1_LACP3	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)	OTU2VHWR	HIBCH_HUMAN	Protein Interaction/Cellular Processes	[11]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[12]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[13]
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Post-Translational Modifications	[14]
Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1)	OT6C1WQD	ACS2L_HUMAN	Gene/Protein Processing	[15]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[15]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[16]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[17]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[18]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Protein Interaction/Cellular Processes	[11]

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