General Information of Drug (ID: DMMG2TO)

Drug Name
D-glucose Drug Info
Synonyms
D-Glucopyranose; Glucopyranose; D-Glc; D-Glcp; Glucodin; Meritose; Clintose L; Roferose ST; CPC hydrate; Clearsweet 95; 2280-44-6; Staleydex 95M; CHEBI:4167; Glucopyranoside; D-Glucopyranoside; Glc; (3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol; Glucopyranose, D-; DSSTox_CID_2910; Glucose solution; D-Glucopyranose, anhydrous; glc-ring; D-glucose-ring; Cartose Cerelose; Staleydex 130; Glucose 40; EINECS 218-914-5; Meritose 200; Glc-OH
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
5793
ChEBI ID
CHEBI:4167
CAS Number
CAS 2280-44-6
TTD Drug ID
DMMG2TO
VARIDT Drug ID
DR00165
INTEDE Drug ID
DR2081

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [20]
dehydroascorbic acid DMKYQO4 Discovery agent N.A. Investigative [21]
Arsenite DMBCO4Q Discovery agent N.A. Investigative [22]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [23]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [24]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [25]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [27]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [33]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [38]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [33]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [44]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [46]
Quercetin DM3NC4M Obesity 5B81 Approved [47]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Fructose DM43AN2 Vomiting MD90 Approved [49]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [50]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [34]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [58]
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Drug(s) Affected By Nitric oxide synthase 1 (NOS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [60]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [61]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [61]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [63]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
Capsaicin DMGMF6V Back pain ME84.Z Approved [65]
Bortezomib DMNO38U Leukemia Approved [66]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [67]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Fructose DM43AN2 Vomiting MD90 Approved [70]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [71]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [73]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [74]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
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Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [88]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [90]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [97]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [98]
Fructose DM43AN2 Vomiting MD90 Approved [43]
Ketoprofen DMRKXPT Bursitis Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [103]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [108]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [110]
Selenium DM25CGV N. A. N. A. Approved [111]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [112]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [116]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [117]
Mebendazole DMO14SG Ascariasis 1F62 Approved [118]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [119]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [119]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [117]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [124]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [125]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [126]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [59]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [59]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [127]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Methotrexate DM2TEOL Anterior urethra cancer Approved [131]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
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Drug(s) Affected By SPARC (SPARC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [137]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [140]
Folic Acid DMEMBJC Colorectal carcinoma Approved [141]
Paclitaxel DMLB81S Breast carcinoma Approved [142]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [147]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [61]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [61]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [153]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Folic Acid DMEMBJC Colorectal carcinoma Approved [156]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [153]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [158]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [160]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [161]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [166]
Selenium DM25CGV N. A. N. A. Approved [32]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [167]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [172]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [173]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [174]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [175]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [176]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [177]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [178]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [179]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [180]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [181]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [182]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Ethacrynic acid DM60QMR Edema MG29 Approved [183]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [184]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [185]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [186]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [188]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [189]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [190]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [191]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [108]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [192]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [193]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Gefitinib DM15F0X Colon adenocarcinoma Approved [195]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [197]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [199]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [203]
Epinephrine DM3KJBC Acute asthma CA23 Approved [204]
Quercetin DM3NC4M Obesity 5B81 Approved [205]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [61]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [207]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [210]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [212]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [213]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [214]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [216]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [217]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [217]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [218]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [219]
Okadaic acid DM47CO1 Discovery agent N.A. Investigative [220]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [221]
Myricetin DMTV4L0 Discovery agent N.A. Investigative [222]
(E)-4-(3,5-dimethoxystyryl)phenol DMYXI2V Discovery agent N.A. Investigative [223]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [224]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Benzatropine DMF7EXL Parkinsonian disorder Approved [26]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [225]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [226]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [227]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Benzatropine DMF7EXL Parkinsonian disorder Approved [26]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [231]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [236]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [237]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [238]
[3H]methyltrienolone DMTSGOW Discovery agent N.A. Investigative [239]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein SEC13 homolog (SEC13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [242]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [32]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Selenium DM25CGV N. A. N. A. Approved [32]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [244]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [245]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [245]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [246]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [247]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [248]
Etidronic acid DM1XHYJ Bone Paget disease Approved [245]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [245]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [245]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [249]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [250]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [251]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [252]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [253]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [254]
Cepharanthine DM9Y5JB N. A. N. A. Approved [255]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [256]
Clozapine DMFC71L Schizophrenia 6A20 Approved [257]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [258]
Trifluoperazine DMKBYWI Anxiety Approved [259]
Olanzapine DMPFN6Y Bipolar depression Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Indomethacin DMSC4A7 Bursitis Approved [198]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [260]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [261]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [262]
Quercetin DM3NC4M Obesity 5B81 Approved [263]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [93]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [265]
Haloperidol DM96SE0 Delirium Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [266]
Selenium DM25CGV N. A. N. A. Approved [267]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [268]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [269]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [272]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Prednisone DM2HG4X Acute asthma CA23 Approved [273]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [274]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [275]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [276]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [278]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [279]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [281]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [55]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [282]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [283]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [284]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Magnesium DMU4ORS Ischemic stroke 8B11.5Z Approved [285]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [237]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [286]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [287]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Acetylcholinesterase (ACHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetylcholine DMDF79Z Cataract 9B10 Approved [288]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [289]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [290]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [291]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [290]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [292]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [293]
Neostigmine DM6T2J3 Myasthenia gravis 8C6Y Approved [294]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [295]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [296]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Folic Acid DMEMBJC Colorectal carcinoma Approved [297]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [298]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [299]
Orlistat DMRJSP8 Obesity 5B81 Approved [300]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [301]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [303]
Ketoprofen DMRKXPT Bursitis Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [266]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [304]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [305]
Quercetin DM3NC4M Obesity 5B81 Approved [306]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [307]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [308]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
Adefovir DMM278X N. A. N. A. Approved [43]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [309]
CHLORIDE DM1TJXA Solid tumour/cancer 2A00-2F9Z Phase 3 [310]
AMG 386 DMQJXL4 Breast cancer 2C60-2C65 Phase 3 [311]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
Selenious acid DMB7GPA N. A. N. A. Investigative [313]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Selenium DM25CGV N. A. N. A. Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [315]
Quercetin DM3NC4M Obesity 5B81 Approved [316]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [317]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hemoglobin subunit beta (HBB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [321]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [322]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Voxelotor DMCS6M5 Sickle-cell disorder 3A51 Approved [323]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [324]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [298]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [301]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [325]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [329]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [326]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
CERC-801 DM3SZ7P N. A. N. A. Phase 2 [330]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynamin-1-like protein (DNM1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [331]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [332]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [333]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [334]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [335]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [331]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [336]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [337]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [338]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [340]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [341]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Fructose DM43AN2 Vomiting MD90 Approved [70]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [343]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [338]
Folic Acid DMEMBJC Colorectal carcinoma Approved [297]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [345]
Gefitinib DM15F0X Colon adenocarcinoma Approved [346]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Selenium DM25CGV N. A. N. A. Approved [347]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [349]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [351]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [352]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [353]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Quercetin DM3NC4M Obesity 5B81 Approved [92]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [355]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [356]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calumenin (CALU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [296]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Benzatropine DMF7EXL Parkinsonian disorder Approved [26]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [332]
Selenium DM25CGV N. A. N. A. Approved [32]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [334]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [335]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [341]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [360]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nephrin (NPHS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [362]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [363]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [364]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [365]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [367]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
PIRINIXIC ACID DM82Y75 Pulmonary fibrosis CB03.4 Preclinical [365]
Puromycin DMDKLB5 N. A. N. A. Preclinical [368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gremlin-1 (GREM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [202]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [370]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [371]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [372]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [373]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [374]
Quercetin DM3NC4M Obesity 5B81 Approved [375]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [374]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [376]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [377]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [379]
Quercetin DM3NC4M Obesity 5B81 Approved [380]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [381]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [382]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [383]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [384]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome b (CYTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [385]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [343]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [338]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Urethane DM7NSI0 N. A. N. A. Phase 4 [386]
Fialuridine DMCIGRB Hepatitis B virus infection 1E51.0 Phase 2 [387]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [388]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [389]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [390]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [43]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [391]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [394]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [396]
Quercetin DM3NC4M Obesity 5B81 Approved [295]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [229]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [397]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [398]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [397]
Menthol DMG2KW7 Back pain ME84.Z Approved [399]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [400]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [401]
Haloperidol DM96SE0 Delirium Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [403]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [404]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Epinephrine DM3KJBC Acute asthma CA23 Approved [204]
Quercetin DM3NC4M Obesity 5B81 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [406]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [407]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [408]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [410]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [412]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [413]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [414]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Haptoglobin (HP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [192]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [415]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [416]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [417]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [95]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [418]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [95]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [421]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [422]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [423]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [424]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [425]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [426]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [427]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [428]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [429]
Verapamil DMA7PEW Angina pectoris BA40 Approved [430]
Selenium DM25CGV N. A. N. A. Approved [431]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [430]
Quercetin DM3NC4M Obesity 5B81 Approved [432]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [433]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [434]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [435]
Gefitinib DM15F0X Colon adenocarcinoma Approved [436]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [154]
Selenium DM25CGV N. A. N. A. Approved [437]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [168]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [438]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [439]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [128]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [440]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [441]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [442]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [443]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [444]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [445]
Prednisone DM2HG4X Acute asthma CA23 Approved [446]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [447]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [448]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-nerve growth factor (NGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [272]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
MCI-186 DM8ZHP1 Amyotrophic lateral sclerosis 8B60.0 Approved [450]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [451]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [452]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [453]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcitonin (CALCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [454]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [455]
Folic Acid DMEMBJC Colorectal carcinoma Approved [297]
Nizatidine DMGFV3Z Acid-reflux disorder DA22 Approved [454]
Capsaicin DMGMF6V Back pain ME84.Z Approved [456]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [457]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [458]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Epinephrine DM3KJBC Acute asthma CA23 Approved [459]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [460]
Fructose DM43AN2 Vomiting MD90 Approved [461]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [463]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [464]
Propranolol DM79NTF Angina pectoris BA40 Approved [465]
Testosterone DM7HUNW Hot flushes GA30 Approved [466]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [467]
Diazepam DM08E9O Alcohol withdrawal Approved [468]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [170]
Methotrexate DM2TEOL Anterior urethra cancer Approved [469]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [470]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [471]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [472]
Quercetin DM3NC4M Obesity 5B81 Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [467]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [474]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [475]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [478]
Testosterone DM7HUNW Hot flushes GA30 Approved [479]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein E (APOE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [481]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [482]
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [483]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Aripiprazole DM3NUMH Bipolar I disorder Approved [484]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [485]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [486]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ethacrynic acid DM60QMR Edema MG29 Approved [487]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [308]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [488]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [43]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [489]
Diazepam DM08E9O Alcohol withdrawal Approved [490]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [491]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [167]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [492]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [493]
Methotrexate DM2TEOL Anterior urethra cancer Approved [494]
Quercetin DM3NC4M Obesity 5B81 Approved [495]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet factor 4 (PF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [496]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [497]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [498]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [498]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [499]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [500]
Arsenic DMTL2Y1 N. A. N. A. Approved [501]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [502]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [503]
Gefitinib DM15F0X Colon adenocarcinoma Approved [504]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [505]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [506]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [507]
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [505]
Estrone DM5T6US Acne vulgaris ED80 Approved [510]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [272]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [511]
Etretinate DM2CZFA Keratosis ED56 Approved [512]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [513]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [514]
Quercetin DM3NC4M Obesity 5B81 Approved [515]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [516]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [517]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [154]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [518]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fructose DM43AN2 Vomiting MD90 Approved [519]
Oxcarbazepine DM5PU6O Epilepsy 8A60-8A68 Approved [520]
Estrone DM5T6US Acne vulgaris ED80 Approved [521]
Testosterone DM7HUNW Hot flushes GA30 Approved [522]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Dienestrol DMBSXI0 Atrophic vaginitis GA30.2 Approved [521]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [521]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [521]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Selenium DM25CGV N. A. N. A. Approved [32]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [295]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [523]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [524]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [276]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [525]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [526]
Paclitaxel DMLB81S Breast carcinoma Approved [527]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [528]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [529]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [530]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [531]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [532]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [533]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ethanol DMDRQZU Chronic pain MG30 Approved [535]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [35]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [536]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [536]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [537]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-3 (ITGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [538]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [539]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [540]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [541]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [542]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [543]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [545]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A8 (S100A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [546]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [117]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [117]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [548]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [549]
Methotrexate DM2TEOL Anterior urethra cancer Approved [550]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [551]
Quercetin DM3NC4M Obesity 5B81 Approved [552]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [553]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [554]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [43]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [43]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [555]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [556]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [557]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [558]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [559]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [560]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [561]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [562]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [376]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [563]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [564]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [565]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [547]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [202]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [566]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [189]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [567]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [110]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [415]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [568]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [569]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [570]
Quercetin DM3NC4M Obesity 5B81 Approved [571]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [572]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [573]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [574]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [575]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [575]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [429]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [576]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [577]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [578]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [579]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [580]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [581]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [582]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [583]
Fructose DM43AN2 Vomiting MD90 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [584]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [190]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [585]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [586]
Methotrexate DM2TEOL Anterior urethra cancer Approved [587]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-1 (ITGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [588]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [546]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [589]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin receptor (INSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [591]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [592]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [593]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [594]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [595]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [212]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [596]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gelsolin (GSN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Selenium DM25CGV N. A. N. A. Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [440]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [455]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [597]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [598]
Gefitinib DM15F0X Colon adenocarcinoma Approved [599]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [600]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [438]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [601]
Methotrexate DM2TEOL Anterior urethra cancer Approved [602]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [603]
Quercetin DM3NC4M Obesity 5B81 Approved [604]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A9 (S100A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [546]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [154]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [605]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [606]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [607]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [608]
Quercetin DM3NC4M Obesity 5B81 Approved [228]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [609]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [90]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-V (ITGAV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Epinephrine DM3KJBC Acute asthma CA23 Approved [610]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [611]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [612]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [613]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [612]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [612]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [612]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [440]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [614]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [615]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [616]
Selenium DM25CGV N. A. N. A. Approved [617]
Methotrexate DM2TEOL Anterior urethra cancer Approved [618]
Quercetin DM3NC4M Obesity 5B81 Approved [619]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [620]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [621]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [622]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombomodulin (THBD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [623]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [624]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [625]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Procathepsin L (CTSL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [137]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [626]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [627]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [628]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [629]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [626]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [630]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [631]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [628]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [632]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [546]
Quercetin DM3NC4M Obesity 5B81 Approved [633]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [202]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [240]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [634]
Gefitinib DM15F0X Colon adenocarcinoma Approved [635]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [167]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [636]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [637]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [638]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [480]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [329]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [639]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [640]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [641]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [455]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Arsenic DMTL2Y1 N. A. N. A. Approved [642]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [643]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [644]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [612]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [612]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [645]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [614]
Fluoxetine DM3PD2C Bipolar depression Approved [612]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [59]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-5 (ITGA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [468]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [316]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [240]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [646]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [647]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A5 (ANXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [648]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Benzatropine DMF7EXL Parkinsonian disorder Approved [26]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [649]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [650]
Diazepam DM08E9O Alcohol withdrawal Approved [468]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [651]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [652]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [653]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [654]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [655]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-enolase (ENO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Estrone DM5T6US Acne vulgaris ED80 Approved [656]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [657]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [138]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [217]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [658]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [192]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [91]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [189]
Verapamil DMA7PEW Angina pectoris BA40 Approved [660]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [661]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [581]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [662]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [412]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [664]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [665]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [666]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [667]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [668]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [667]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [669]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [670]
Methotrexate DM2TEOL Anterior urethra cancer Approved [671]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [672]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [673]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [674]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [675]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [676]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [677]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [380]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [639]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [640]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [678]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [679]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [680]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [681]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [682]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [683]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [467]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [684]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [685]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [686]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [687]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [688]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Estrone DM5T6US Acne vulgaris ED80 Approved [688]
Testosterone DM7HUNW Hot flushes GA30 Approved [689]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Ethanol DMDRQZU Chronic pain MG30 Approved [690]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [691]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [650]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [692]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [455]
Ethanol DMDRQZU Chronic pain MG30 Approved [693]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [694]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [374]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [695]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [696]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [697]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [315]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [698]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [699]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [700]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [701]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [702]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [703]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [704]
Hydralazine DMU8JGH Chronic heart failure BD1Z Approved [705]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [706]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [707]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [708]
Quercetin DM3NC4M Obesity 5B81 Approved [709]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [417]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [593]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [710]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [86]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [711]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [542]
Paclitaxel DMLB81S Breast carcinoma Approved [142]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [547]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Selenium DM25CGV N. A. N. A. Approved [32]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [542]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [712]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Paclitaxel DMLB81S Breast carcinoma Approved [142]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase B-type (CKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [713]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [523]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [43]
Fosinopril DM9NJ52 Chronic heart failure BD1Z Approved [43]
Quinapril DMR8H31 Chronic heart failure BD1Z Approved [43]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [714]
Perindopril DMOPZDT Hypertension BA00-BA04 Approved [715]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [716]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [717]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [718]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [378]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [719]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [720]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [507]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [721]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [589]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [722]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [723]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [724]
Mitotane DMU1GX0 Adrenocortical carcinoma 2D11.Z Approved [725]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [726]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [727]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [728]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [729]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [567]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Gefitinib DM15F0X Colon adenocarcinoma Approved [730]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [445]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [731]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [581]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [732]
Quercetin DM3NC4M Obesity 5B81 Approved [733]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [734]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [735]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [736]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [737]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [738]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [739]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [740]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [741]
Methotrexate DM2TEOL Anterior urethra cancer Approved [742]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [743]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [744]
Quercetin DM3NC4M Obesity 5B81 Approved [745]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [746]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [741]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plastin-3 (PLS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Haloperidol DM96SE0 Delirium Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [747]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [748]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [749]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [750]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [751]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ethanol DMDRQZU Chronic pain MG30 Approved [752]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Arsenic DMTL2Y1 N. A. N. A. Approved [753]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [583]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [754]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endoplasmin (HSP90B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [51]
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [755]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [756]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [757]
Fructose DM43AN2 Vomiting MD90 Approved [70]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [343]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [71]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Haloperidol DM96SE0 Delirium Approved [758]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [759]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [760]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [761]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Selenium DM25CGV N. A. N. A. Approved [431]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [762]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [669]
Methotrexate DM2TEOL Anterior urethra cancer Approved [763]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [764]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [765]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Folate receptor alpha (FOLR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ethanol DMDRQZU Chronic pain MG30 Approved [766]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [767]
Bortezomib DMNO38U Leukemia Approved [768]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [769]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [414]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [217]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [770]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [771]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [772]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [773]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [774]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [775]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [61]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [261]
Selenium DM25CGV N. A. N. A. Approved [431]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [486]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [240]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Tetracaine DM9J6C2 Spinal anesthesia MB40.3 Approved [776]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [645]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [712]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [777]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [43]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [778]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-galactosidase (GLB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [272]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [779]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [780]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [781]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [130]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [497]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [478]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [783]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [784]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [785]
Folic Acid DMEMBJC Colorectal carcinoma Approved [786]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E-selectin (SELE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [788]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [789]
Methotrexate DM2TEOL Anterior urethra cancer Approved [790]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [791]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [792]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [793]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [794]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [795]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [796]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [374]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [797]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [798]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [799]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [800]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [801]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [338]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [785]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [802]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [217]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [217]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [803]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [804]
Quercetin DM3NC4M Obesity 5B81 Approved [805]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [523]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Capsaicin DMGMF6V Back pain ME84.Z Approved [806]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [467]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [807]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [808]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Haloperidol DM96SE0 Delirium Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [809]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [810]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [811]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [810]
Bortezomib DMNO38U Leukemia Approved [812]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [810]
BAICALEIN DM4C7E6 Influenza virus infection 1E30-1E32 Phase 2 [810]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [813]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [374]
Quercetin DM3NC4M Obesity 5B81 Approved [316]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [374]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [376]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [563]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [374]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [814]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [815]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [329]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [126]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [816]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [817]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [818]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [702]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [819]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [758]
Methamphetamine DMPM4SK Anxiety Approved [820]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [821]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [296]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [822]
Quercetin DM3NC4M Obesity 5B81 Approved [823]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [824]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cofilin-1 (CFL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [825]
Haloperidol DM96SE0 Delirium Approved [26]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [43]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [826]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [827]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [43]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [43]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [43]
Gefitinib DM15F0X Colon adenocarcinoma Approved [828]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [802]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [828]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [828]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [829]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [830]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [503]
Gefitinib DM15F0X Colon adenocarcinoma Approved [831]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [600]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [710]
Selenium DM25CGV N. A. N. A. Approved [32]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [168]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [832]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 receptor (EDNRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Selenium DM25CGV N. A. N. A. Approved [32]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [833]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [834]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [798]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [835]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [835]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [836]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [837]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [192]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [838]
Testosterone undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [839]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [837]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [666]
Methotrexate DM2TEOL Anterior urethra cancer Approved [840]
Epinephrine DM3KJBC Acute asthma CA23 Approved [841]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [175]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [59]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [842]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-3 (MT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [823]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [843]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [844]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [845]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [846]
Arsenic DMTL2Y1 N. A. N. A. Approved [847]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [43]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [848]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [849]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [850]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [851]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [852]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [853]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [854]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [855]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [856]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [857]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [858]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [859]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [860]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [861]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [862]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [863]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [864]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [865]
Gefitinib DM15F0X Colon adenocarcinoma Approved [866]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [867]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Sibutramine DMFJTDI Obesity 5B81 Approved [868]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [869]
Bortezomib DMNO38U Leukemia Approved [870]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [871]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [32]
WP-1066 DMUGHWR Recurrent glioblastoma 2A00.00 Phase 1/2 [871]
MG-132 DMKA2YS N. A. N. A. Preclinical [872]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [873]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [861]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [874]
Paclitaxel DMLB81S Breast carcinoma Approved [875]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [876]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [860]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [100]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [863]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [877]
Methotrexate DM2TEOL Anterior urethra cancer Approved [531]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [86]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [878]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [202]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [879]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [615]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [880]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Bortezomib DMNO38U Leukemia Approved [370]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [881]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [882]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [110]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [580]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [883]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [884]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [885]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [886]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [887]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [624]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [296]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [656]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKLR (PKLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [264]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [888]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [134]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [134]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [889]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [817]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sorcin (SRI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [890]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [340]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [891]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-5 (CDH5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [892]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [893]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [686]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [36]
Ethanol DMDRQZU Chronic pain MG30 Approved [894]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [895]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [896]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [584]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [897]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [898]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [899]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [900]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [901]
Testosterone DM7HUNW Hot flushes GA30 Approved [902]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [903]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [904]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [478]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
Methotrexate DM2TEOL Anterior urethra cancer Approved [43]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [238]
paraquat DMR8O3X Discovery agent N.A. Investigative [905]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [906]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [907]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [908]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [169]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [822]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [909]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [910]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [911]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [912]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [913]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [914]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [435]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Testosterone DM7HUNW Hot flushes GA30 Approved [915]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [916]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [913]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [914]
Leflunomide DMR8ONJ Arthritis FA20 Approved [917]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [134]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [134]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [889]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [499]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [36]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [36]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [367]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Arsenic DMTL2Y1 N. A. N. A. Approved [918]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [919]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [920]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [367]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [921]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [782]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [922]
Haloperidol DM96SE0 Delirium Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
Orlistat DMRJSP8 Obesity 5B81 Approved [923]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [442]
Diazepam DM08E9O Alcohol withdrawal Approved [468]
Quercetin DM3NC4M Obesity 5B81 Approved [924]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [925]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [835]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [835]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [926]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [926]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [455]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [43]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [927]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [305]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [928]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [929]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [617]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [930]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [931]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [844]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [932]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [468]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [588]
Quercetin DM3NC4M Obesity 5B81 Approved [604]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [933]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [844]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [934]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [650]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [402]
Gefitinib DM15F0X Colon adenocarcinoma Approved [935]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [600]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Etretinate DM2CZFA Keratosis ED56 Approved [936]
Prednisone DM2HG4X Acute asthma CA23 Approved [273]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [668]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [937]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Mpv17 (MPV17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Urethane DM7NSI0 N. A. N. A. Phase 4 [386]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [237]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [938]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [43]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [909]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [939]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [940]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [941]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [942]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [943]
Quercetin DM3NC4M Obesity 5B81 Approved [944]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [295]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Benzatropine DMF7EXL Parkinsonian disorder Approved [26]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [567]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [945]
Quercetin DM3NC4M Obesity 5B81 Approved [946]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [947]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [567]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [567]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [948]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [949]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [950]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Selenium DM25CGV N. A. N. A. Approved [32]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [951]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [952]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [167]
Fructose DM43AN2 Vomiting MD90 Approved [519]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [953]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [687]
SR141716A DMCO5JZ Obesity 5B81 Approved [954]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [889]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [955]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [956]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [957]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [442]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [958]
Gefitinib DM15F0X Colon adenocarcinoma Approved [959]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [960]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [168]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [961]
Quercetin DM3NC4M Obesity 5B81 Approved [962]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [87]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [815]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [963]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [964]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [965]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [526]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [966]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [967]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [968]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [969]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [970]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [848]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [620]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [971]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [90]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [217]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [972]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [584]
Gefitinib DM15F0X Colon adenocarcinoma Approved [102]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [586]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [55]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [973]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [586]
Ethacrynic acid DM60QMR Edema MG29 Approved [974]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [598]
Gefitinib DM15F0X Colon adenocarcinoma Approved [831]
Prednisone DM2HG4X Acute asthma CA23 Approved [273]
Methotrexate DM2TEOL Anterior urethra cancer Approved [975]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [976]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [506]
Quercetin DM3NC4M Obesity 5B81 Approved [977]
Fluoxetine DM3PD2C Bipolar depression Approved [978]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [979]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [980]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Gefitinib DM15F0X Colon adenocarcinoma Approved [981]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [982]
Epinephrine DM3KJBC Acute asthma CA23 Approved [841]
Quercetin DM3NC4M Obesity 5B81 Approved [983]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [984]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [985]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [986]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [189]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [379]
Quercetin DM3NC4M Obesity 5B81 Approved [987]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [879]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [988]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [989]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [990]
Selenium DM25CGV N. A. N. A. Approved [32]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [167]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [374]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [991]
Quercetin DM3NC4M Obesity 5B81 Approved [633]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [440]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [992]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [314]
Gefitinib DM15F0X Colon adenocarcinoma Approved [599]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [993]
Selenium DM25CGV N. A. N. A. Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [994]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [995]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [996]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [377]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [431]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [419]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Clozapine DMFC71L Schizophrenia 6A20 Approved [997]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [998]
Cysteamine DMSYFM8 Nephropathic cystinosis 5C60 Approved [999]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [1000]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [440]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [233]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1001]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1002]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [90]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [1003]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Selenium DM25CGV N. A. N. A. Approved [32]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [1004]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1005]
Methotrexate DM2TEOL Anterior urethra cancer Approved [763]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1006]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [686]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amiloride DMRTSGP Congestive heart failure BD10 Approved [1007]
Arsenic DMTL2Y1 N. A. N. A. Approved [1008]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1009]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1010]
Harmine DMPA5WD Discovery agent N.A. Patented [1011]
Hexadecanoic acid DMWUXDZ Discovery agent N.A. Investigative [1012]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By ATP-citrate synthase (ACLY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [374]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1013]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [1014]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [1015]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1016]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [1017]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [683]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [1018]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [260]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [666]
Meloxicam DM2AR7L Arthritis FA20 Approved [1019]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1020]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1021]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gasdermin-D (GSDMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [99]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [658]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [885]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [1022]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [658]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [1023]
Paclitaxel DMLB81S Breast carcinoma Approved [1024]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [337]
Methotrexate DM2TEOL Anterior urethra cancer Approved [45]
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1025]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Paclitaxel DMLB81S Breast carcinoma Approved [1026]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [596]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [494]
Quercetin DM3NC4M Obesity 5B81 Approved [380]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Panobinostat DM58WKG Chronic graft versus host disease Approved [1027]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1028]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [1029]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1030]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [531]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1031]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [541]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [193]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1031]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [1032]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [1033]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [126]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [645]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [768]
Paclitaxel DMLB81S Breast carcinoma Approved [1034]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1035]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [533]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fractalkine (CX3CL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [61]
Fructose DM43AN2 Vomiting MD90 Approved [409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [836]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [61]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1036]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [803]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [1037]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1038]
Arsenic DMTL2Y1 N. A. N. A. Approved [1039]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A12 (S100A12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [763]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [605]
Arsenic DMTL2Y1 N. A. N. A. Approved [501]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
Miglitol DMXBQAM Diabetic complication 5A2Y Approved [1040]
Arecoline DMFJZK3 Parkinson disease 8A00.0 Phase 1 [1041]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
Milchsaure DM462BT Pruritus EC90 Investigative [1042]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1043]
Quercetin DM3NC4M Obesity 5B81 Approved [924]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [94]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1044]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [398]
Ethanol DMDRQZU Chronic pain MG30 Approved [1045]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [359]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [1046]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein 3 (RBM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [690]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1047]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [1048]
Gefitinib DM15F0X Colon adenocarcinoma Approved [664]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [1018]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [695]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1049]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [1050]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1051]
Quercetin DM3NC4M Obesity 5B81 Approved [1052]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1053]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [1054]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [1055]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1056]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1057]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [1058]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [1058]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1059]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1060]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [1058]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [1058]
Ethacrynic acid DM60QMR Edema MG29 Approved [1058]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1058]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [379]
Quercetin DM3NC4M Obesity 5B81 Approved [1061]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1062]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [879]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Testosterone DM7HUNW Hot flushes GA30 Approved [1063]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [880]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1064]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transgelin (TAGLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [612]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [83]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [613]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [612]
Methotrexate DM2TEOL Anterior urethra cancer Approved [156]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [612]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [612]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1065]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [613]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiopoietin-1 receptor (TEK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [835]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [835]
Propranolol DM79NTF Angina pectoris BA40 Approved [1066]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1067]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [1068]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Gefitinib DM15F0X Colon adenocarcinoma Approved [866]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1069]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1070]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [379]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [37]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [611]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [163]
Selenium DM25CGV N. A. N. A. Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1071]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1072]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1073]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1074]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Focal adhesion kinase 1 (PTK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [864]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1075]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [546]
Quercetin DM3NC4M Obesity 5B81 Approved [1076]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1077]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1078]
Testosterone DM7HUNW Hot flushes GA30 Approved [1079]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [1080]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [1081]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [1082]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1083]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [1084]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [1085]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1086]
Etretinate DM2CZFA Keratosis ED56 Approved [52]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [53]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [488]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [54]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1087]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [1088]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [895]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [678]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [848]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [682]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [59]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [1018]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [600]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Meloxicam DM2AR7L Arthritis FA20 Approved [1089]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [668]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [728]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1090]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [176]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [1091]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1092]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1093]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [852]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1094]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [624]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [90]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [903]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [924]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1095]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [398]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [803]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1096]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [32]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1097]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [992]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [1098]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [991]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [1099]
Quinidine DMLPICK N. A. N. A. Approved [1100]
Verapamil DMA7PEW Angina pectoris BA40 Approved [1101]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [1102]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [1102]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [1103]
Propranolol DM79NTF Angina pectoris BA40 Approved [1104]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [1105]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [1106]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [1102]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [958]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [374]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [992]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [343]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1107]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [562]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [338]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [1108]
Ethanol DMDRQZU Chronic pain MG30 Approved [1109]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1108]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1110]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [889]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [1111]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [924]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [611]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Ethanol DMDRQZU Chronic pain MG30 Approved [1045]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [442]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [958]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [1113]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [645]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [883]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [467]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1114]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [653]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [925]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1115]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1116]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [885]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [1117]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [210]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [210]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [1118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1119]
Selenium DM25CGV N. A. N. A. Approved [32]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [883]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [885]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [217]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [217]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1120]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [645]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [891]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1121]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [341]
Arsenic DMTL2Y1 N. A. N. A. Approved [1122]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1123]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [361]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [1125]
paraquat DMR8O3X Discovery agent N.A. Investigative [337]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [221]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [338]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1126]
Ciprofibrate DMGC5DB Hyperlipoproteinemia 5C80 Approved [1127]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1128]
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1119]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [541]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [611]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [924]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [925]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [210]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [210]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [567]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [567]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [1129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [912]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [567]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [1130]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1131]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [567]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [948]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1132]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Verapamil DMA7PEW Angina pectoris BA40 Approved [660]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Selenium DM25CGV N. A. N. A. Approved [32]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [1133]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [774]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [1134]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1135]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [531]
Quercetin DM3NC4M Obesity 5B81 Approved [306]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [86]
Ethacrynic acid DM60QMR Edema MG29 Approved [974]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1136]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1138]
Methotrexate DM2TEOL Anterior urethra cancer Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [1139]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1140]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [1141]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [1088]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1142]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1143]
Prednisone DM2HG4X Acute asthma CA23 Approved [1144]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [1144]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1145]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1146]
Epinephrine DM3KJBC Acute asthma CA23 Approved [1147]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Fluoxetine DM3PD2C Bipolar depression Approved [1148]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [1149]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1150]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [237]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [219]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [645]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [883]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [825]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [68]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1151]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [56]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Testosterone enanthate DMB6871 N. A. N. A. Approved [234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [149]
Drug(s) Affected By Mitofusin-1 (MFN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [396]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Ethanol DMDRQZU Chronic pain MG30 Approved [335]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [1152]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [340]
Bortezomib DMNO38U Leukemia Approved [768]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Arsenic DMTL2Y1 N. A. N. A. Approved [1153]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1154]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytoglobin (CYGB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1155]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Arsenic DMTL2Y1 N. A. N. A. Approved [1156]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [125]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [1157]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [227]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [237]
PMID27336223-Compound-5 DM6E50A N. A. N. A. Patented [125]
EUGENOL DM7US1H Discovery agent N.A. Patented [1157]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [1158]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aquaporin-3 (AQP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [763]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [702]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ampicillin DMHWE7P Acute epiglottitis Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [128]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1159]
Quercetin DM3NC4M Obesity 5B81 Approved [1160]
Estrone DM5T6US Acne vulgaris ED80 Approved [1161]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [1162]
Testosterone DM7HUNW Hot flushes GA30 Approved [1163]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1165]
Mestranol DMG3F94 Contraception QA21 Approved [1166]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [1167]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [554]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [296]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1169]
Arsenic DMTL2Y1 N. A. N. A. Approved [1170]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [302]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Bortezomib DMNO38U Leukemia Approved [812]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [1171]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [1014]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1047]
Urethane DM7NSI0 N. A. N. A. Phase 4 [386]
Beta-caryophyllene DM7583A Pain MG30-MG3Z Phase 2 [1172]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [1173]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1174]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1175]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [280]
Selenium DM25CGV N. A. N. A. Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [645]
Quercetin DM3NC4M Obesity 5B81 Approved [1176]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [72]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1177]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [1178]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1179]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [1180]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1116]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [885]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [1181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [329]
Ethanol DMDRQZU Chronic pain MG30 Approved [1182]
Atropine DMEN6X7 Organophosphate poisoning NE6Z Approved [117]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1119]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [1183]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [1184]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1185]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [1183]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [1184]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [1186]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [407]
Selenium DM25CGV N. A. N. A. Approved [32]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [1187]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1189]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [1190]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [1191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [1192]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [332]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1193]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [1194]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1195]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1196]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [1197]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [958]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [960]
Methotrexate DM2TEOL Anterior urethra cancer Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1198]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1200]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [1201]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [815]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [388]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [1125]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [264]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [296]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1202]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [1120]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH oxidase 4 (NOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [727]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [281]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1204]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1205]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [134]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [889]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [126]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [1206]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [15]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Fluoxetine DM3PD2C Bipolar depression Approved [1148]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [357]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [666]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [333]
Quercetin DM3NC4M Obesity 5B81 Approved [23]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1207]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1208]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual oxidase 2 (DUOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [823]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [817]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [533]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
paraquat DMR8O3X Discovery agent N.A. Investigative [1209]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Dual oxidase 1 (DUOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1210]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1150]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1010]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1211]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1212]
paraquat DMR8O3X Discovery agent N.A. Investigative [1213]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1214]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1215]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [1215]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1216]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [1217]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [121]
Lansoprazole DMXYLQ3 Gastric ulcer DA60 Approved [1217]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [1214]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Sodium Acetate Anhydrous DMH21E0 Hyponatraemia 5C72 Approved [15]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [777]
Urethane DM7NSI0 N. A. N. A. Phase 4 [386]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [749]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [232]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
Milchsaure DM462BT Pruritus EC90 Investigative [1042]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [372]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [374]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [374]
Quercetin DM3NC4M Obesity 5B81 Approved [1218]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [374]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [376]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [377]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1219]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [1125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1220]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [1221]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1222]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Bendamustine hydrochloride DMFH15Z leukaemia 2A60-2B33 Approved [1223]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethacrynic acid DM60QMR Edema MG29 Approved [487]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [901]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [611]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [1225]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1226]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1227]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [533]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [884]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [885]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ethanol DMDRQZU Chronic pain MG30 Approved [752]
Menthol DMG2KW7 Back pain ME84.Z Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [852]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [624]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [392]
Testosterone DM7HUNW Hot flushes GA30 Approved [522]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1228]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [341]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [771]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [89]
Ethanol DMDRQZU Chronic pain MG30 Approved [693]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [817]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [366]
3,4-Dihydroxycinnamic Acid DMVZL26 Thrombocytopenia 3B64 Phase 4 [1229]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1230]
CERC-801 DM3SZ7P N. A. N. A. Phase 2 [1231]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [75]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [612]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [614]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [613]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [612]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [612]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Fluoxetine DM3PD2C Bipolar depression Approved [612]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [79]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [614]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1232]
Selenium DM25CGV N. A. N. A. Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [1233]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [32]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [157]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1096]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Quercetin DM3NC4M Obesity 5B81 Approved [391]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [358]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1035]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [150]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [825]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1234]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [82]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ethanol DMDRQZU Chronic pain MG30 Approved [1235]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [596]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1237]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [1238]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [596]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [28]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Clozapine DMFC71L Schizophrenia 6A20 Approved [26]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [339]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1239]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1239]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Testosterone DM7HUNW Hot flushes GA30 Approved [115]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [417]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [241]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
Fructose DM43AN2 Vomiting MD90 Approved [1240]
Urethane DM7NSI0 N. A. N. A. Phase 4 [386]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Testosterone DM7HUNW Hot flushes GA30 Approved [411]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1241]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [411]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [344]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1242]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1242]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [533]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [1243]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [1244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [104]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [167]
Quercetin DM3NC4M Obesity 5B81 Approved [1245]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [547]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [31]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [1246]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [81]
Testosterone DM7HUNW Hot flushes GA30 Approved [1247]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [951]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [951]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [192]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [369]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [120]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [544]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Selenium DM25CGV N. A. N. A. Approved [32]
Epinephrine DM3KJBC Acute asthma CA23 Approved [1147]
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [883]
Panobinostat DM58WKG Chronic graft versus host disease Approved [36]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1248]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [523]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [394]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [395]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [30]
Leflunomide DMR8ONJ Arthritis FA20 Approved [39]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [217]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [217]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [217]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [217]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [217]
Fructose DM43AN2 Vomiting MD90 Approved [1240]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [194]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [1003]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [196]
Selenium DM25CGV N. A. N. A. Approved [32]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [645]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [376]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [377]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1219]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1249]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [1250]
Arsenic DMTL2Y1 N. A. N. A. Approved [663]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [249]
Quercetin DM3NC4M Obesity 5B81 Approved [1251]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [440]
Artemether DM48QOT Malaria 1F40-1F45 Approved [1252]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1253]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [85]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1254]
Estrone DM5T6US Acne vulgaris ED80 Approved [1255]
Leflunomide DMR8ONJ Arthritis FA20 Approved [917]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
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Drug(s) Affected By Resistin (RETN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [620]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1256]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [950]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1257]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [1258]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [1259]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [312]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1260]
isobutylmethylxanthine DM46F5X Discovery agent N.A. Investigative [1261]
Icosapentum DMF1CM7 N. A. N. A. Investigative [1262]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [84]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1263]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [152]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [148]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [211]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [57]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [230]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Sodium/glucose cotransporter 2 (SLC5A2) DTKNH2D SC5A2_HUMAN Substrate [2]
Glucose transporter type 1, erythrocyte/brain (SLC2A1) DTG3T6X GTR1_HUMAN Substrate [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
ADP-dependent glucokinase (ADPGK) DENZGO4 ADPGK_HUMAN Substrate [4]
Brain form hexokinase (HK1) DEDMAGE HXK1_HUMAN Substrate [5]
Alcohol dehydrogenase (ADH) DEKU5HL A4L2V0_LACRE Substrate [6] , [7]
D-Lactate dehydrogenase (ldhA) DEQUGC0 A0A1C7BXR3_PSEAI Substrate [8] , [9]
Alpha-glucosidase (aglA) DEAMSKV PAGL1_LACP3 Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH) OTU2VHWR HIBCH_HUMAN Protein Interaction/Cellular Processes [11]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [12]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Gene/Protein Processing [13]
Acetyl-CoA carboxylase 2 (ACACB) OT96UIP1 ACACB_HUMAN Post-Translational Modifications [14]
Acetyl-coenzyme A synthetase 2-like, mitochondrial (ACSS1) OT6C1WQD ACS2L_HUMAN Gene/Protein Processing [15]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2) OTB1FZJU ACSA_HUMAN Gene/Protein Processing [15]
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Gene/Protein Processing [16]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [17]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [18]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Protein Interaction/Cellular Processes [11]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4536).
2 The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977.
3 The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38.
4 The Structural and functional characterization of mammalian ADP-dependent glucokinase. J Biol Chem. 2016 Feb 19;291(8):3694-704.
5 Nonaggregating mutant of recombinant human hexokinase I exhibits wild-type kinetics and rod-like conformations in solution. Biochemistry. 1999 Jun 29;38(26):8359-66.
6 1,3-Propanediol:NAD+ oxidoreductases of Lactobacillus brevis and Lactobacillus buchneri. Appl Environ Microbiol. 1992 Jun;58(6):2005-10.
7 Aciduric strains of Lactobacillus reuteri and Lactobacillus rhamnosus, isolated from human feces, have strong adhesion and aggregation properties. Probiotics Antimicrob Proteins. 2018 Mar;10(1):89-97.
8 Presence of lactate dehydrogenase and lactate racemase in Megasphaera elsdenii grown on glucose or lactate. Appl Environ Microbiol. 1993 Jan;59(1):255-9.
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761 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
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776 Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells. Chem Biol Interact. 2023 Nov 1;385:110730. doi: 10.1016/j.cbi.2023.110730. Epub 2023 Oct 7.
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780 Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes. Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17018-23. doi: 10.1073/pnas.0607873103. Epub 2006 Oct 30.
781 Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging. Arch Toxicol. 2020 Jan;94(1):89-101. doi: 10.1007/s00204-019-02607-2. Epub 2019 Nov 16.
782 Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
783 Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
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785 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
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787 Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model. Endocr Relat Cancer. 2010 Feb 18;17(1):169-77. doi: 10.1677/ERC-09-0170. Print 2010 Mar.
788 Platelet/endothelial biomarkers in depressed patients treated with the selective serotonin reuptake inhibitor sertraline after acute coronary events: the Sertraline AntiDepressant Heart Attack Randomized Trial (SADHART) Platelet Substudy. Circulation. 2003 Aug 26;108(8):939-44. doi: 10.1161/01.CIR.0000085163.21752.0A. Epub 2003 Aug 11.
789 Vitamin E inhibits lipid peroxidation-induced adhesion molecule expression in endothelial cells and decreases soluble cell adhesion molecules in healthy subjects. Cardiovasc Res. 2003 Feb;57(2):563-71. doi: 10.1016/s0008-6363(02)00699-5.
790 Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
791 Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: evidence of different vascular protection by different lipid-lowering treatments. J Clin Endocrinol Metab. 2003 Nov;88(11):5341-7. doi: 10.1210/jc.2003-030724.
792 Bile acids induce adhesion molecule expression in endothelial cells through activation of reactive oxygen species, NF-kappaB, and p38. Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H741-7. doi: 10.1152/ajpheart.01182.2005. Epub 2006 Mar 31.
793 The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926). Toxicology. 2006 Jan 20;218(1):30-8. doi: 10.1016/j.tox.2005.09.014. Epub 2005 Nov 16.
794 Effects of hormone treatment on hemostasis variables. Climacteric. 2007 Oct;10 Suppl 2:32-7. doi: 10.1080/13697130701598548.
795 Markers of inflammation, thrombosis and endothelial activation correlate with carotid IMT regression in stable coronary disease after atorvastatin treatment. Nutr Metab Cardiovasc Dis. 2009 Sep;19(7):481-90. doi: 10.1016/j.numecd.2008.10.003. Epub 2009 Jan 26.
796 Modulation of endothelial cell activation in sickle cell disease: a pilot study. Blood. 2001 Apr 1;97(7):1937-41. doi: 10.1182/blood.v97.7.1937.
797 Editor's Highlight: Mechanistic Toxicity Tests Based on an Adverse Outcome Pathway Network for Hepatic Steatosis. Toxicol Sci. 2017 Sep 1;159(1):159-169. doi: 10.1093/toxsci/kfx121.
798 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
799 Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
800 Regulation of CD36 expression in human melanoma cells. Adv Exp Med Biol. 2002;507:337-42. doi: 10.1007/978-1-4615-0193-0_52.
801 Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc. Cell Biol Toxicol. 2021 Jun;37(3):379-400. doi: 10.1007/s10565-020-09540-6. Epub 2020 Jul 25.
802 A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy. Molecules. 2023 Oct 17;28(20):7132. doi: 10.3390/molecules28207132.
803 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
804 Activation of ERK1/2 by protein kinase C-alpha in response to hydrogen peroxide-induced cell death in human gingival fibroblasts. Toxicol In Vitro. 2010 Feb;24(1):319-26. doi: 10.1016/j.tiv.2009.08.007. Epub 2009 Aug 21.
805 Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015 Sep;42(9):1419-29. doi: 10.1007/s11033-015-3921-7. Epub 2015 Aug 27.
806 The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells. Cytokine. 2011 Jun;54(3):330-7. doi: 10.1016/j.cyto.2011.03.010. Epub 2011 Apr 6.
807 Effect of arsenic trioxide on vascular endothelial cell proliferation and expression of vascular endothelial growth factor receptors Flt-1 and KDR in gastric cancer in nude mice. World J Gastroenterol. 2007 Dec 28;13(48):6498-505. doi: 10.3748/wjg.v13.i48.6498.
808 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
809 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
810 Assessing 12(S)-lipoxygenase inhibitory activity using colorectal cancer cells overexpressing the enzyme. Food Chem Toxicol. 2007 Mar;45(3):508-14. doi: 10.1016/j.fct.2006.08.013. Epub 2006 Aug 30.
811 Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages. Metabolism. 2003 May;52(5):652-7. doi: 10.1053/meta.2003.50100.
812 Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
813 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
814 Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
815 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
816 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
817 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
818 Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Biochem J. 2003 Oct 1;375(Pt 1):167-74. doi: 10.1042/BJ20030661.
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820 Microglial and astrocytic changes in the striatum of methamphetamine abusers. Leg Med (Tokyo). 2010 Mar;12(2):57-62. doi: 10.1016/j.legalmed.2009.11.001. Epub 2010 Jan 27.
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822 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
823 Quercetin reduces oxidative damage induced by paraquat via modulating expression of antioxidant genes in A549 cells. J Appl Toxicol. 2013 Dec;33(12):1460-7. doi: 10.1002/jat.2812. Epub 2012 Sep 20.
824 The differential effects of bupivacaine and lidocaine on prostaglandin E2 release, cyclooxygenase gene expression and pain in a clinical pain model. Anesth Analg. 2008 Jan;106(1):321-7, table of contents.
825 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
826 Quercetin protected against isoniazide-induced HepG2 cell apoptosis by activating the SIRT1/ERK pathway. J Biochem Mol Toxicol. 2019 Sep;33(9):e22369. doi: 10.1002/jbt.22369. Epub 2019 Jul 23.
827 Drug-induced liver injury: Oltipraz and C2-ceramide intervene HNF-1/GSTA1 expression via JNK signaling pathway. J Appl Toxicol. 2021 Dec;41(12):2011-2020. doi: 10.1002/jat.4181. Epub 2021 May 6.
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830 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
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832 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
833 Molecular analysis of cocaine-induced endothelial dysfunction: role of endothelin-1 and nitric oxide. Cardiovasc Toxicol. 2008 Dec;8(4):161-71.
834 Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
835 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
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837 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
838 Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
839 Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
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846 Altered ErbB receptor signaling and gene expression in cisplatin-resistant ovarian cancer. Cancer Res. 2005 Aug 1;65(15):6789-800. doi: 10.1158/0008-5472.CAN-04-2684.
847 Metallothionein 3: an androgen-upregulated gene enhances cell invasion and tumorigenesis of prostate carcinoma cells. Prostate. 2013 Oct;73(14):1495-506. doi: 10.1002/pros.22697. Epub 2013 Jun 21.
848 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
849 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
850 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem. 2001 Dec 21;276(51):47828-33. doi: 10.1074/jbc.M106103200. Epub 2001 Oct 8.
851 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
852 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
853 Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget. 2017 Feb 14;8(7):11127-11143. doi: 10.18632/oncotarget.12091.
854 Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
855 The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Int J Oncol. 2007 Mar;30(3):641-50.
856 Cyclophosphamide perturbs cytosine methylation in Jurkat-T cells through LSD1-mediated stabilization of DNMT1 protein. Chem Res Toxicol. 2011 Nov 21;24(11):2040-3. doi: 10.1021/tx2003849. Epub 2011 Nov 1.
857 DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
858 Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. Hum Pathol. 2006 Mar;37(3):298-311.
859 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
860 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
861 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
862 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
863 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
864 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
865 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
866 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
867 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
868 Sibutramine provokes apoptosis of aortic endothelial cells through altered production of reactive oxygen and nitrogen species. Toxicol Appl Pharmacol. 2017 Jan 1;314:1-11. doi: 10.1016/j.taap.2016.11.003. Epub 2016 Nov 9.
869 Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules. Toxicol Lett. 2016 Jan 5;240(1):32-42. doi: 10.1016/j.toxlet.2015.10.005. Epub 2015 Oct 22.
870 Molecular mechanisms of bortezomib resistant adenocarcinoma cells. PLoS One. 2011;6(12):e27996. doi: 10.1371/journal.pone.0027996. Epub 2011 Dec 22.
871 Regulation of PSMB5 protein and subunits of mammalian proteasome by constitutively activated signal transducer and activator of transcription 3 (STAT3): potential role in bortezomib-mediated anticancer therapy. J Biol Chem. 2014 May 2;289(18):12612-22. doi: 10.1074/jbc.M113.542829. Epub 2014 Mar 13.
872 The role of PSMB5 in sodium arsenite-induced oxidative stress in L-02 cells. Cell Stress Chaperones. 2020 May;25(3):533-540. doi: 10.1007/s12192-020-01104-1. Epub 2020 Apr 16.
873 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
874 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
875 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
876 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
877 Complex genetic response of human cells to sublethal levels of pure nitric oxide. Cancer Res. 1998 Aug 1;58(15):3435-40.
878 Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
879 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
880 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
881 The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
882 Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1 Axis. J Nat Prod. 2021 May 28;84(5):1563-1572. doi: 10.1021/acs.jnatprod.1c00083. Epub 2021 May 6.
883 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
884 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
885 Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
886 The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1 and VEGF via the PI3K/AKT and ERK1/2 signaling pathways. Chin J Nat Med. 2022 Sep;20(9):679-690. doi: 10.1016/S1875-5364(22)60172-9.
887 Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin. J Cardiovasc Pharmacol. 2007 May;49(5):299-305. doi: 10.1097/FJC.0b013e31803d35ce.
888 Aluminum toxicity triggers the nuclear translocation of HIF-1alpha and promotes anaerobiosis in hepatocytes. Toxicol In Vitro. 2007 Feb;21(1):16-24. doi: 10.1016/j.tiv.2006.07.013. Epub 2006 Aug 5.
889 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
890 DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
891 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
892 Disruption of endothelial adherens junction by invasive breast cancer cells is mediated by reactive oxygen species and is attenuated by AHCC. Life Sci. 2013 Dec 18;93(25-26):994-1003. doi: 10.1016/j.lfs.2013.10.027. Epub 2013 Nov 6.
893 H(1)R mediates local anesthetic-induced vascular permeability in angioedema. Toxicol Appl Pharmacol. 2020 Apr 1;392:114921. doi: 10.1016/j.taap.2020.114921. Epub 2020 Feb 12.
894 Ethanol disrupts vascular endothelial barrier: implication in cancer metastasis. Toxicol Sci. 2012 May;127(1):42-53. doi: 10.1093/toxsci/kfs087. Epub 2012 Feb 13.
895 Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
896 Chlorpyrifos, permethrin and cyfluthrin effect on cell survival, permeability, and tight junction in an in-vitro model of the human blood-brain barrier (BBB). Neurotoxicology. 2022 Dec;93:152-162. doi: 10.1016/j.neuro.2022.09.010. Epub 2022 Sep 24.
897 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
898 Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
899 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
900 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
901 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
902 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
903 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
904 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
905 Plasma surfactant D in patients following acute paraquat intoxication. Clin Toxicol (Phila). 2007 Jun-Aug;45(5):463-7. doi: 10.1080/15563650701338138.
906 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
907 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
908 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
909 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
910 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
911 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
912 Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
913 Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol. 2022 Jan;96(1):195-210. doi: 10.1007/s00204-021-03177-y. Epub 2021 Oct 23.
914 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
915 Effects of testosterone and metformin on glucose metabolism in endometrium. Fertil Steril. 2010 May 1;93(7):2295-8. doi: 10.1016/j.fertnstert.2009.01.096. Epub 2009 Mar 27.
916 Downregulation of glucose-6-phosphatase expression contributes to fluoxetine-induced hepatic steatosis. J Appl Toxicol. 2021 Aug;41(8):1232-1240. doi: 10.1002/jat.4109. Epub 2020 Nov 12.
917 Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
918 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
919 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
920 Peroxisome proliferator-activated receptor gamma as a molecular target of resveratrol-induced modulation of polyamine metabolism. Cancer Res. 2006 Jul 15;66(14):7348-54. doi: 10.1158/0008-5472.CAN-05-2777.
921 SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003 Aug 1;102(3):795-801. doi: 10.1182/blood-2002-10-3023. Epub 2003 Mar 20.
922 Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 2004 Aug 15;64(16):5617-23. doi: 10.1158/0008-5472.CAN-03-3927.
923 Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor. FASEB J. 2006 Oct;20(12):2027-35. doi: 10.1096/fj.05-5404com.
924 Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
925 Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
926 Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms. Cell Biol Toxicol. 2023 Aug;39(4):1395-1411. doi: 10.1007/s10565-022-09766-6. Epub 2022 Oct 8.
927 Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice. J Pharmacol Exp Ther. 2018 Mar;364(3):452-461. doi: 10.1124/jpet.117.243105. Epub 2018 Jan 9.
928 Delta5 desaturase mRNA levels are increased by simvastatin via SREBP-1 at early stages, not via PPARalpha, in THP-1 cells. Eur J Pharmacol. 2007 Oct 1;571(2-3):97-105.
929 Inhibition of liver x receptor/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in vitro. Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1228-36. doi: 10.1161/ATVBAHA.110.205500. Epub 2010 Mar 25.
930 Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction. Cancer Sci. 2018 Sep;109(9):2757-2766. doi: 10.1111/cas.13701. Epub 2018 Jul 20.
931 Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins. Biol Reprod. 2007 Aug;77(2):303-11. doi: 10.1095/biolreprod.107.060244. Epub 2007 May 2.
932 Trabectedin induces ferroptosis via regulation of HIF-1/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells. Chem Biol Interact. 2023 Jan 5;369:110262. doi: 10.1016/j.cbi.2022.110262. Epub 2022 Nov 14.
933 Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017 Oct;24:147-158. doi: 10.1016/j.ebiom.2017.09.022. Epub 2017 Sep 19.
934 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
935 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
936 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
937 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
938 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
939 Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
940 Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicol Appl Pharmacol. 2020 Dec 1;408:115273. doi: 10.1016/j.taap.2020.115273. Epub 2020 Oct 6.
941 Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. doi: 10.1593/neo.06781.
942 Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
943 Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
944 Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
945 Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs. Int J Cardiol. 2010 Apr 1;140(1):73-81. doi: 10.1016/j.ijcard.2008.11.017. Epub 2008 Dec 6.
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948 Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
949 The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
950 Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol. 2009 Mar 20;133(1):23-31. doi: 10.1016/j.ijcard.2007.11.058. Epub 2008 Jan 15.
951 Comparative ligand-binding analysis of ten human lipocalins. Biochim Biophys Acta. 2006 Feb;1764(2):161-73. doi: 10.1016/j.bbapap.2005.12.006. Epub 2006 Jan 6.
952 Chrysin ameliorates hepatic steatosis induced by a diet deficient in methionine and choline by inducing the secretion of hepatocyte nuclear factor 4-dependent very low-density lipoprotein. J Biochem Mol Toxicol. 2020 Jul;34(7):e22497. doi: 10.1002/jbt.22497. Epub 2020 Mar 27.
953 Repression of hepatocyte nuclear factor 4 alpha by AP-1 underlies dyslipidemia associated with retinoic acid. J Lipid Res. 2019 Apr;60(4):794-804. doi: 10.1194/jlr.M088880. Epub 2019 Feb 1.
954 Rimonabant suppresses RNA transcription of hepatitis B virus by inhibiting hepatocyte nuclear factor 4. Microbiol Immunol. 2020 May;64(5):345-355. doi: 10.1111/1348-0421.12777. Epub 2020 Feb 25.
955 Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter. Mol Pharmacol. 2008 Feb;73(2):451-60.
956 The effect of estrogen compounds on human embryoid bodies. Reprod Sci. 2013 Jun;20(6):661-9. doi: 10.1177/1933719112462630. Epub 2012 Nov 26.
957 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
958 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
959 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
960 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
961 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
962 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
963 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
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965 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
966 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
967 Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
968 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
969 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
970 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
971 Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma. Toxicol Appl Pharmacol. 2017 Sep 15;331:54-61. doi: 10.1016/j.taap.2017.05.008. Epub 2017 May 10.
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973 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
974 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
975 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
976 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
977 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
978 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
979 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
980 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
981 The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
982 NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
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985 Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
986 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
987 Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling. Phytother Res. 2016 Nov;30(11):1833-1840. doi: 10.1002/ptr.5689. Epub 2016 Jul 29.
988 Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres. Acta Neuropathol Commun. 2014 Mar 31;2:31. doi: 10.1186/2051-5960-2-31.
989 Ivermectin as an inhibitor of cancer stem?like cells. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8.
990 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
991 Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
992 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
993 The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
994 Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
995 Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
996 Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
997 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
998 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
999 Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer. PLoS One. 2012;7(4):e34437. doi: 10.1371/journal.pone.0034437. Epub 2012 Apr 20.
1000 Positive regulation of hepatic carnitine palmitoyl transferase 1A (CPT1A) activities by soy isoflavones and L-carnitine. Eur J Nutr. 2006 Mar;45(3):159-64. doi: 10.1007/s00394-005-0576-5. Epub 2005 Dec 20.
1001 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
1002 Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
1003 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
1004 Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem. 2003 May 16;278(20):18092-100. doi: 10.1074/jbc.M300265200. Epub 2003 Mar 13.
1005 TNF-related apoptosis-inducing ligand cooperates with NSAIDs via activated Wnt signalling in (pre)malignant colon cells. J Pathol. 2011 Feb;223(3):378-89. doi: 10.1002/path.2797. Epub 2010 Oct 29.
1006 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
1007 PDX-1 protein is internalized by lipid raft-dependent macropinocytosis. Cell Transplant. 2005;14(9):637-45. doi: 10.3727/000000005783982648.
1008 Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013 Feb;27(2):106-15. doi: 10.1002/jbt.21462. Epub 2013 Jan 11.
1009 Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism. J Biol Chem. 2011 Feb 25;286(8):6049-60. doi: 10.1074/jbc.M110.176842. Epub 2010 Dec 16.
1010 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
1011 A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication. Nat Med. 2015 Apr;21(4):383-8. doi: 10.1038/nm.3820. Epub 2015 Mar 9.
1012 PPARgamma-dependent and -independent effects of rosiglitazone on lipotoxic human pancreatic islets. Biochem Biophys Res Commun. 2008 Feb 22;366(4):1096-101. doi: 10.1016/j.bbrc.2007.12.088. Epub 2007 Dec 26.
1013 Effects of antiepileptic drugs on lipogenic gene regulation and hyperlipidemia risk in Taiwan: a nationwide population-based cohort study and supporting in vitro studies. Arch Toxicol. 2018 Sep;92(9):2829-2844. doi: 10.1007/s00204-018-2263-3. Epub 2018 Jul 13.
1014 Prenatal caffeine exposure increases the susceptibility to non-alcoholic fatty liver disease in female offspring rats via activation of GR-C/EBP-SIRT1 pathway. Toxicology. 2019 Apr 1;417:23-34. doi: 10.1016/j.tox.2019.02.008. Epub 2019 Feb 15.
1015 Brexpiprazole suppresses cell proliferation and de novo lipogenesis through AMPK/SREBP1 pathway in colorectal cancer. Environ Toxicol. 2023 Oct;38(10):2352-2360. doi: 10.1002/tox.23871. Epub 2023 Jun 22.
1016 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
1017 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
1018 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
1019 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
1020 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
1021 Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
1022 Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis. Inflamm Res. 2021 May;70(5):543-552. doi: 10.1007/s00011-021-01457-y. Epub 2021 Apr 13.
1023 Dexmedetomidine protects against Ropivacaine-induced neuronal pyroptosis via the Nrf2/HO-1 pathway. J Toxicol Sci. 2023;48(3):139-148. doi: 10.2131/jts.48.139.
1024 The role of Caspase-1/GSDMD-mediated pyroptosis in Taxol-induced cell death and a Taxol-resistant phenotype in nasopharyngeal carcinoma regulated by autophagy. Cell Biol Toxicol. 2020 Oct;36(5):437-457. doi: 10.1007/s10565-020-09514-8. Epub 2020 Jan 28.
1025 Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
1026 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
1027 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
1028 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol. 2019 Mar;234(3):2606-2617. doi: 10.1002/jcp.27073. Epub 2018 Oct 14.
1029 Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.
1030 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
1031 Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
1032 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
1033 Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
1034 Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
1035 The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
1036 Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF- production in human leukemia cells with expressed Bcr/Abl. Biochem Pharmacol. 2013 Sep 1;86(5):620-31. doi: 10.1016/j.bcp.2013.06.009. Epub 2013 Jun 20.
1037 The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res. 2004 Jan;19(1):147-54. doi: 10.1359/jbmr.2004.19.1.147.
1038 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
1039 Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
1040 The -glucosidase inhibitor miglitol decreases glucose fluctuations and inflammatory cytokine gene expression in peripheral leukocytes of Japanese patients with type 2 diabetes mellitus. Metabolism. 2010 Dec;59(12):1816-22. doi: 10.1016/j.metabol.2010.06.006. Epub 2010 Jul 29.
1041 Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol Sci. 2007 Nov;100(1):66-74.
1042 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
1043 Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25. doi: 10.1016/j.bbrc.2004.04.108.
1044 Inhibition of TGF-/SMAD3/NF-B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2014 Nov 18;231(1):55-61. doi: 10.1016/j.toxlet.2014.08.024. Epub 2014 Sep 6.
1045 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
1046 Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
1047 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
1048 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
1049 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
1050 Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
1051 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
1052 Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
1053 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
1054 The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicol Appl Pharmacol. 2012 May 15;261(1):42-9. doi: 10.1016/j.taap.2012.03.009.
1055 Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum Mol Genet. 1994 Oct;3(10):1763-9. doi: 10.1093/hmg/3.10.1763.
1056 PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
1057 NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
1058 A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
1059 Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
1060 Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
1061 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
1062 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
1063 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
1064 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
1065 Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun. 2006 Dec 15;351(2):321-7. doi: 10.1016/j.bbrc.2006.09.171. Epub 2006 Oct 17.
1066 Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chem Biol Interact. 2020 Jan 25;316:108925. doi: 10.1016/j.cbi.2019.108925. Epub 2019 Dec 12.
1067 Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
1068 Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
1069 The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1712-20. doi: 10.1167/iovs.07-0477.
1070 Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1. J Biol Chem. 2009 Oct 9;284(41):28476-28484. doi: 10.1074/jbc.M109.050864. Epub 2009 Aug 25.
1071 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
1072 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
1073 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
1074 Troglitazone selectively inhibits glyoxalase I gene expression. Diabetologia. 2001 Nov;44(11):2004-12. doi: 10.1007/s001250100004.
1075 Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
1076 Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
1077 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
1078 Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
1079 Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
1080 Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
1081 Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. Cell Rep. 2018 Apr 17;23(3):866-877. doi: 10.1016/j.celrep.2018.03.087.
1082 Protein kinase Cdelta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs. J Biol Chem. 1998 Dec 18;273(51):34639-45. doi: 10.1074/jbc.273.51.34639.
1083 Aspirin induces apoptosis through release of cytochrome c from mitochondria. Neoplasia. 2000 Nov-Dec;2(6):505-13. doi: 10.1038/sj.neo.7900120.
1084 Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
1085 Lipid raft-dependent death receptor 5 (DR5) expression and activation are critical for ursodeoxycholic acid-induced apoptosis in gastric cancer cells. Carcinogenesis. 2011 May;32(5):723-31. doi: 10.1093/carcin/bgr038. Epub 2011 Feb 28.
1086 The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity. Chem Biol Interact. 2008 Sep 25;175(1-3):318-26. doi: 10.1016/j.cbi.2008.05.038. Epub 2008 Jun 12.
1087 Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
1088 Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
1089 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
1090 Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):204-9. doi: 10.1093/abbs/gmq130. Epub 2011 Jan 21.
1091 Modulation of receptor phosphorylation contributes to activation of peroxisome proliferator activated receptor alpha by dehydroepiandrosterone and other peroxisome proliferators. Mol Pharmacol. 2008 Mar;73(3):968-76. doi: 10.1124/mol.107.036780. Epub 2007 Dec 13.
1092 (9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARalpha in MDA-MB-231 breast cancer cells. Toxicology. 2014 Dec 4;326:18-24.
1093 Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
1094 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
1095 Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
1096 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
1097 Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy. Biochem Pharmacol. 2010 Apr 15;79(8):1200-9. doi: 10.1016/j.bcp.2009.12.007. Epub 2009 Dec 14.
1098 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
1099 Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
1100 Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
1101 Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
1102 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
1103 Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
1104 Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
1105 Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
1106 Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
1107 Comparative effects of fructose and glucose on lipogenic gene expression and intermediary metabolism in HepG2 liver cells. PLoS One. 2011;6(11):e26583. doi: 10.1371/journal.pone.0026583. Epub 2011 Nov 11.
1108 On the mechanism for PPAR agonists to enhance ABCA1 gene expression. Atherosclerosis. 2009 Aug;205(2):413-9. doi: 10.1016/j.atherosclerosis.2009.01.008. Epub 2009 Jan 19.
1109 The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake. Arch Toxicol. 2022 Sep;96(9):2487-2499. doi: 10.1007/s00204-022-03325-y. Epub 2022 Jun 17.
1110 Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. J Lipid Res. 2004 Nov;45(11):2015-24. doi: 10.1194/jlr.M400049-JLR200. Epub 2004 Aug 16.
1111 Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8.
1112 Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
1113 Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
1114 Naringin protects human adipose-derived mesenchymal stem cells against hydrogen peroxide-induced inhibition of osteogenic differentiation. Chem Biol Interact. 2015 Dec 5;242:255-61. doi: 10.1016/j.cbi.2015.10.010. Epub 2015 Oct 19.
1115 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
1116 AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
1117 Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. doi: 10.1124/mol.106.025890. Epub 2006 May 24.
1118 Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2016 Nov 1;310:140-149. doi: 10.1016/j.taap.2016.09.010. Epub 2016 Sep 14.
1119 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
1120 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
1121 Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
1122 Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. Chem Res Toxicol. 2011 Mar 21;24(3):340-9. doi: 10.1021/tx1003112. Epub 2011 Jan 14.
1123 Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
1124 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
1125 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
1126 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
1127 Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. J Biol Chem. 2014 Aug 8;289(32):22437-49. doi: 10.1074/jbc.M114.548933. Epub 2014 Jul 1.
1128 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
1129 Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and candesartan in hypertensive patients. Eur Heart J. 2007 Jun;28(12):1440-7. doi: 10.1093/eurheartj/ehm101. Epub 2007 May 5.
1130 Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Circ J. 2009 Dec;73(12):2282-7. doi: 10.1253/circj.cj-09-0387. Epub 2009 Sep 29.
1131 Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs. Life Sci. 2020 Jun 15;251:117607. doi: 10.1016/j.lfs.2020.117607. Epub 2020 Mar 30.
1132 (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
1133 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
1134 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
1135 Madecassoside ameliorates cisplatin-induced nephrotoxicity by inhibiting activation of the mitogen activated protein kinase pathway. Environ Toxicol. 2023 Jul;38(7):1473-1483. doi: 10.1002/tox.23777. Epub 2023 Apr 23.
1136 Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
1137 Aspirin-mediated COX-2 transcript stabilization via sustained p38 activation in human intestinal myofibroblasts. Mol Pharmacol. 2004 Feb;65(2):470-8.
1138 Protective effect of quercetin on hydrogen peroxide-induced tight junction disruption. Int J Toxicol. 2010 Jul;29(4):418-24. doi: 10.1177/1091581810366487. Epub 2010 May 5.
1139 Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 May;139(5):965-74. doi: 10.3945/jn.108.100867. Epub 2009 Mar 18.
1140 Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. Toxicol Lett. 2020 Oct 10;332:146-154. doi: 10.1016/j.toxlet.2020.07.010. Epub 2020 Jul 16.
1141 The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia. Clin Pharmacol Ther. 2006 Oct;80(4):375-83. doi: 10.1016/j.clpt.2006.07.002.
1142 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
1143 AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
1144 Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
1145 NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
1146 Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
1147 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
1148 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
1149 SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
1150 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
1151 In vitro and in vivo effects of the PPAR-alpha agonists fenofibrate and retinoic acid in endometrial cancer. Mol Cancer. 2006 Mar 28;5:13.
1152 Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model. Toxicol In Vitro. 2021 Sep;75:105191. doi: 10.1016/j.tiv.2021.105191. Epub 2021 May 5.
1153 Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014 Apr;55(3):196-208. doi: 10.1002/em.21842. Epub 2013 Dec 10.
1154 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
1155 Aryl hydrocarbon receptor ligand 5F 203 induces oxidative stress that triggers DNA damage in human breast cancer cells. Chem Res Toxicol. 2015 May 18;28(5):855-71.
1156 Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
1157 Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
1158 Persistence of epigenomic effects after recovery from repeated treatment with two nephrocarcinogens. Front Genet. 2018 Dec 3;9:558.
1159 Combined tamoxifen and gefitinib in non-small cell lung cancer shows antiproliferative effects. Biomed Pharmacother. 2010 Feb;64(2):88-92. doi: 10.1016/j.biopha.2009.06.010. Epub 2009 Oct 23.
1160 Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Environ Toxicol. 2020 Nov;35(11):1179-1193. doi: 10.1002/tox.22983. Epub 2020 Jun 12.
1161 Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology. 2001 Sep 14;166(1-2):79-89. doi: 10.1016/s0300-483x(01)00437-1.
1162 Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen alpha and beta receptors. FASEB J. 2006 Jul;20(9):1552-4. doi: 10.1096/fj.05-5413fje. Epub 2006 May 23.
1163 Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications. Toxicol Lett. 2010 Feb 15;192(3):298-315. doi: 10.1016/j.toxlet.2009.11.004. Epub 2009 Nov 12.
1164 Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
1165 Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.
1166 Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul;66(7):1479-87. doi: 10.1271/bbb.66.1479.
1167 Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies. J Med Chem. 2011 Jan 13;54(1):302-11. doi: 10.1021/jm101163m. Epub 2010 Dec 3.
1168 Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One. 2013 Oct 4;8(10):e75905. doi: 10.1371/journal.pone.0075905. eCollection 2013.
1169 Cisplatin regulates the MAPK kinase pathway to induce increased expression of DNA repair gene ERCC1 and increase melanoma chemoresistance. Oncogene. 2012 May 10;31(19):2412-22. doi: 10.1038/onc.2011.426. Epub 2011 Sep 26.
1170 Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water. Int J Cancer. 2003 Apr 10;104(3):263-8. doi: 10.1002/ijc.10968.
1171 Genotoxic stress and activation of novel DNA repair enzymes in human endothelial cells and in the retinas and kidneys of streptozotocin diabetic rats. Diabetes Metab Res Rev. 2012 May;28(4):329-37. doi: 10.1002/dmrr.2279.
1172 -Caryophyllene attenuates palmitate-induced lipid accumulation through AMPK signaling by activating CB2 receptor in human HepG2 hepatocytes. Mol Nutr Food Res. 2016 Oct;60(10):2228-2242. doi: 10.1002/mnfr.201600197. Epub 2016 Jun 16.
1173 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
1174 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
1175 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
1176 The p53/miR-34a/SIRT1 Positive Feedback Loop in Quercetin-Induced Apoptosis. Cell Physiol Biochem. 2015;35(6):2192-202. doi: 10.1159/000374024. Epub 2015 Apr 7.
1177 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
1178 Dual targeting of the antagonistic pathways mediated by Sirt1 and TXNIP as a putative approach to enhance the efficacy of anti-aging interventions. Aging (Albany NY). 2009 Mar 31;1(4):412-24. doi: 10.18632/aging.100035.
1179 Hydroquinone-induced malignant transformation of TK6 cells by facilitating SIRT1-mediated p53 degradation and up-regulating KRAS. Toxicol Lett. 2016 Sep 30;259:133-142. doi: 10.1016/j.toxlet.2016.08.006. Epub 2016 Aug 8.
1180 Iron overload inhibits cell proliferation and promotes autophagy via PARP1/SIRT1 signaling in endometriosis and adenomyosis. Toxicology. 2022 Jan 15;465:153050. doi: 10.1016/j.tox.2021.153050. Epub 2021 Nov 23.
1181 Imatinib-induced hepatotoxicity via oxidative stress and activation of NLRP3 inflammasome: an in vitro and in vivo study. Arch Toxicol. 2022 Apr;96(4):1075-1087. doi: 10.1007/s00204-022-03245-x. Epub 2022 Feb 22.
1182 Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
1183 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
1184 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
1185 The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. Epub 2007 Jun 13.
1186 Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity. Biochem Pharmacol. 2012 Jun 15;83(12):1674-81. doi: 10.1016/j.bcp.2012.02.027. Epub 2012 Mar 7.
1187 Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells. Int J Biomed Sci. 2013 Mar;9(1):18-25.
1188 The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes. Toxicol Sci. 2008 Feb;101(2):341-9. doi: 10.1093/toxsci/kfm273. Epub 2007 Nov 1.
1189 Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol. 2000 Jun 15;164(12):6287-95. doi: 10.4049/jimmunol.164.12.6287.
1190 Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):227-34. doi: 10.1016/j.taap.2011.09.008. Epub 2011 Sep 19.
1191 Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
1192 Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol. 2011 Oct 17;24(10):1644-52. doi: 10.1021/tx200082h. Epub 2011 Aug 22.
1193 Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
1194 Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol In Vitro. 2022 Aug;82:105388. doi: 10.1016/j.tiv.2022.105388. Epub 2022 May 18.
1195 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
1196 PPAR- activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. Toxicol Lett. 2016 Oct 17;260:8-17. doi: 10.1016/j.toxlet.2016.08.016. Epub 2016 Aug 21.
1197 Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. Toxicology. 2023 May 15;490:153506. doi: 10.1016/j.tox.2023.153506. Epub 2023 Apr 5.
1198 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
1199 Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
1200 Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
1201 TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
1202 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
1203 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
1204 Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
1205 Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells. J Biochem Mol Toxicol. 2022 Mar;36(3):e22974. doi: 10.1002/jbt.22974. Epub 2021 Dec 23.
1206 Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact. 2019 Aug 1;308:269-278.
1207 Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice. Apoptosis. 2007 Nov;12(11):2077-87. doi: 10.1007/s10495-007-0116-2. Epub 2007 Aug 16.
1208 Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
1209 CD34+ derived macrophage and dendritic cells display differential responses to paraquat. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9.
1210 DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicol In Vitro. 2018 Feb;46:257-264. doi: 10.1016/j.tiv.2017.10.010. Epub 2017 Oct 12.
1211 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
1212 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
1213 Cytoprotective effect of kaempferol on paraquat-exposed BEAS-2B cells via modulating expression of MUC5AC. Biol Pharm Bull. 2014;37(9):1486-94. doi: 10.1248/bpb.b14-00239.
1214 Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes. 2012 Apr;61(4):797-806. doi: 10.2337/db11-0846. Epub 2012 Feb 14.
1215 Thiazolidinediones are potent inducers of fibroblast growth factor 21 expression in the liver. Biol Pharm Bull. 2011;34(7):1120-1. doi: 10.1248/bpb.34.1120.
1216 Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction. Toxicology. 2017 Mar 1;378:95-106. doi: 10.1016/j.tox.2017.01.009. Epub 2017 Jan 11.
1217 Increased immunoreactivity and concentration of basic fibroblast growth factor in lansoprazole-treated gastric mucosa. J Clin Gastroenterol. 1995;21 Suppl 1:S24-9.
1218 Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26.
1219 Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
1220 Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. J Biol Chem. 2009 Oct 16;284(42):28783-94. doi: 10.1074/jbc.M109.041186. Epub 2009 Aug 18.
1221 Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
1222 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
1223 Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
1224 Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 2007 Feb 2;412(3):211-6. doi: 10.1016/j.neulet.2006.07.045. Epub 2007 Jan 17.
1225 Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
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1227 Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009 Apr 3;1:25-37.
1228 Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. doi: 10.1210/jc.2005-0079. Epub 2005 Oct 4.
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1230 Absorption of resveratrol by vascular endothelial cells through passive diffusion and an SGLT1-mediated pathway. J Nutr Biochem. 2013 Nov;24(11):1823-9. doi: 10.1016/j.jnutbio.2013.04.003. Epub 2013 Aug 6.
1231 Sodium-independent low-affinity D-glucose transport by human sodium/D-glucose cotransporter 1: critical role of tryptophan 561. Biochemistry. 2007 Mar 13;46(10):2758-66. doi: 10.1021/bi061696x. Epub 2007 Feb 9.
1232 Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult. PLoS One. 2014 Jun 30;9(6):e101380. doi: 10.1371/journal.pone.0101380. eCollection 2014.
1233 Decreased macrophage paraoxonase 2 expression in patients with hypercholesterolemia is the result of their increased cellular cholesterol content: effect of atorvastatin therapy. Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):175-80. doi: 10.1161/01.ATV.0000104011.88939.06. Epub 2003 Oct 30.
1234 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
1235 Salvianolic acid B protects against chronic alcoholic liver injury via SIRT1-mediated inhibition of CRP and ChREBP in rats. Toxicol Lett. 2017 Feb 5;267:1-10. doi: 10.1016/j.toxlet.2016.12.010. Epub 2016 Dec 15.
1236 Azacytidine sensitizes acute myeloid leukemia cells to arsenic trioxide by up-regulating the arsenic transporter aquaglyceroporin 9. J Hematol Oncol. 2015 May 8;8:46. doi: 10.1186/s13045-015-0143-3.
1237 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
1238 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
1239 CRISPR-based DNA methylation editing of NNT rescues the cisplatin resistance of lung cancer cells by reducing autophagy. Arch Toxicol. 2023 Feb;97(2):441-456. doi: 10.1007/s00204-022-03404-0. Epub 2022 Nov 6.
1240 A highly conserved hydrophobic motif in the exofacial vestibule of fructose transporting SLC2A proteins acts as a critical determinant of their substrate selectivity. Mol Membr Biol. 2007 Sep-Dec;24(5-6):455-63. doi: 10.1080/09687680701298143.
1241 Ouabain at pathological concentrations might induce damage in human vascular endothelial cells. Acta Pharmacol Sin. 2006 Feb;27(2):165-72. doi: 10.1111/j.1745-7254.2006.00244.x.
1242 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
1243 Long noncoding RNA FAM66C promotes tumor progression and glycolysis in intrahepatic cholangiocarcinoma by regulating hsa-miR-23b-3p/KCND2 axis. Environ Toxicol. 2021 Nov;36(11):2322-2332. doi: 10.1002/tox.23346. Epub 2021 Aug 21.
1244 Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model. World J Surg. 2006 Mar;30(3):333-45. doi: 10.1007/s00268-005-0339-8.
1245 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
1246 Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma. J Clin Oncol. 2005 Aug 10;23(23):5334-46. doi: 10.1200/JCO.2005.03.723. Epub 2005 Jun 6.
1247 DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
1248 Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):834-840. doi: 10.1016/j.bbrc.2019.04.081. Epub 2019 Apr 16.
1249 Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
1250 Cloning and functional characterization of the human GLUT7 isoform SLC2A7 from the small intestine. Am J Physiol Gastrointest Liver Physiol. 2004 Jul;287(1):G236-42. doi: 10.1152/ajpgi.00396.2003. Epub 2004 Mar 19.
1251 Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
1252 Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
1253 Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
1254 Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
1255 Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
1256 PML-RAR interaction with TRIB3 impedes PPAR/RXR function and triggers dyslipidemia in acute promyelocytic leukemia. Theranostics. 2020 Aug 15;10(22):10326-10340. doi: 10.7150/thno.45924. eCollection 2020.
1257 Effects of chronic rosiglitazone therapy on gene expression in human adipose tissue in vivo in patients with type 2 diabetes. J Clin Endocrinol Metab. 2007 Feb;92(2):720-4.
1258 Hesperetin inhibit adipocyte differentiation and enhance Bax- and p21-mediated adipolysis in human mesenchymal stem cell adipogenesis. J Biochem Mol Toxicol. 2015 Mar;29(3):99-108. doi: 10.1002/jbt.21672. Epub 2014 Oct 26.
1259 Adipokines and treatment with niacin. Metabolism. 2006 Oct;55(10):1283-5. doi: 10.1016/j.metabol.2006.07.002.
1260 Bisphenol A is associated with insulin resistance and modulates adiponectin and resistin gene expression in obese children. Pediatr Obes. 2017 Oct;12(5):380-387. doi: 10.1111/ijpo.12154. Epub 2016 May 17.
1261 Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis. J Biochem Mol Toxicol. 2012 Aug;26(8):291-300. doi: 10.1002/jbt.21415. Epub 2012 May 29.
1262 Fatty acids and expression of adipokines. Biochim Biophys Acta. 2005 May 30;1740(2):287-92. doi: 10.1016/j.bbadis.2004.11.019. Epub 2004 Dec 8.
1263 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.