Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM36PKZ)

• Drug Name: PF-3758309 Drug Info
• Synonyms: PF-309

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 25227462
  ChEBI ID: CHEBI:93751
  CAS Number: CAS 898044-15-0
  TTD Drug ID: DM36PKZ

Molecule-Related Drug Atlas

Drug(s) Targeting PAK-4 protein kinase (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
KPT-9274	DM9JXMD	Non-hodgkin lymphoma	2B33.5	Phase 1	[3]

Drug(s) Affected By Serine/threonine-protein kinase PAK 4 (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[6]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[9]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[10]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[11]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[10]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[12]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[16]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[20]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[19]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[17]

Drug(s) Affected By T-box transcription factor TBX3 (TBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[21]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[27]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[21]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[35]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 14 (TNFSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[6]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[41]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[38]

Drug(s) Affected By Nucleolar protein 3 (NOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By STAM-binding protein (STAMBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[47]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[52]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[53]

Drug(s) Affected By Interferon alpha-2 (IFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[54]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[55]
BIX-01294	DM5CBNY	Breast cancer	2C60-2C65	Preclinical	[56]
UNC0638	DM4A1KJ	Discovery agent	N.A.	Investigative	[56]

Drug(s) Affected By Interferon beta (IFNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[60]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[61]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[62]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[62]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[63]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[64]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[65]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[72]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[77]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[77]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[82]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[84]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[85]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[87]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[90]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[91]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[20]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[95]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[96]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]

Drug(s) Affected By Azurocidin (AZU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[107]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[107]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[118]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[119]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[122]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[114]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[123]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[124]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[113]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[116]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[129]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[135]

Drug(s) Affected By CD70 antigen (CD70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[140]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[60]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[141]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[144]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[150]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[153]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[154]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[155]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[94]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[156]
Bortezomib	DMNO38U	Leukemia		Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[158]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[165]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[166]

Drug(s) Affected By Elongation factor 1-alpha 2 (EEF1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[60]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[171]

Drug(s) Affected By Lymphotoxin-beta (LTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[175]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[176]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[82]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[177]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[87]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[178]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[179]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[180]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[78]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[4]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[189]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[192]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[195]

Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[198]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[201]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[202]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[203]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[28]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[209]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[210]

Drug(s) Affected By Gamma-interferon-inducible protein 16 (IFI16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[211]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[60]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[216]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[217]

Drug(s) Affected By Ectodysplasin-A (EDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[219]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[13]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[203]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[224]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[225]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[177]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]

Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[234]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[235]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[236]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[237]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[238]

Drug(s) Affected By Caspase recruitment domain-containing protein 6 (CARD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]

Drug(s) Affected By Protein AATF (AATF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[240]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[241]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[10]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Selenium	DM25CGV	N. A.	N. A.	Approved	[4]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[10]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[5]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[244]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[35]

Drug(s) Affected By Serine/threonine-protein kinase pim-2 (PIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[201]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[246]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[201]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[247]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 18 (TNFSF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[248]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[22]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[251]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[34]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[252]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[253]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
PAK-4 protein kinase (PAK4)	TT7Y3BZ	PAK4_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[2]
Azurocidin (AZU1)	OTHXU264	CAP7_HUMAN	Gene/Protein Processing	[2]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Gene/Protein Processing	[2]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[2]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Gene/Protein Processing	[2]
Bcl-2-associated transcription factor 1 (BCLAF1)	OT7T8H6A	BCLF1_HUMAN	Gene/Protein Processing	[2]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Gene/Protein Processing	[2]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[2]

References

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