Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXOELT)

Drug Name

Midazolam Drug Info

Synonyms

Dazolam; Dormicum; Midanium; Midazolamum; Midosed; Versed; Midazolam Base; Dormicum (TN); Hypnovel (TN); Midacum (TN); Midazolamum [INN-Latin]; Ro 21-3981; Versed (TN); Midazolam (JAN/INN); Midazolam [INN:BAN:JAN]; 4H-Imidazo[1,5-a][1,4]benzodiazepine, 8-chloro-6-(2-fluoro-phenyl)-1-methyl-, (Z)-2-butenedioate; 8-Chlor-6-(2-fluorphenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepin; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine; 8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride; 8-Chloro-6-(O-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]-benzodiazepine; 8-Chloro-6-(o-fluorophenyl)-1-methyl-4H-imidazo(1,5-a)(1,4)benzodiazepine

Indication

Disease Entry	ICD 11	Status	REF
Irritability	MB24	Approved	[1] , [2]
Epilepsy	8A60-8A68	Phase 3	[3]

Therapeutic Class

Hypnotics and Sedatives

Cross-matching ID

PubChem CID: 4192
ChEBI ID: CHEBI:6931
CAS Number: CAS 59467-70-8
TTD Drug ID: DMXOELT
VARIDT Drug ID: DR00684
INTEDE Drug ID: DR1086

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[10]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[11]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[13]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[16]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[17]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[11]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[18]
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Drug(s) Metabolized By Cytochrome P450 4B1 (CYP4B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[19]
Testosterone cypionate	DMC1TEV	Testosterone deficiency	5A81.1	Approved	[19]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[20]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[23]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[24]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[27]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[28]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[23]
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Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Premature labour	JB00	Approved	[29]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[9]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[30]
Sorafenib	DMS8IFC	Hepatocellular carcinoma	2C12.02	Approved	[23]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[23]
Irinotecan	DMP6SC2	Colorectal cancer	2B91.Z	Approved	[23]
Metronidazole	DMTIVEN	Amoebiasis	1A36	Approved	[31]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[32]
Verapamil	DMA7PEW	Hypertension	BA00-BA04	Approved	[9]
Diclofenac	DMPIHLS	Osteoarthritis	FA00-FA05	Approved	[33]
Estrone	DM5T6US	Menopausal and postmenopausal disorder	GA30	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Irinotecan	DMP6SC2	Colorectal cancer	2B91.Z	Approved	[36]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[37]
Nicotine	DMWX5CO	Nicotine dependence	6C4A.2	Approved	[38]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[39]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[40]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[41]
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[42]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[43]
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[44]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[43]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[45]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[43]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[46]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[47]
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Drug(s) Targeting Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Epilepsy	8A60-8A68	Approved	[48]
Flunitrazepam	DMGR5Z3	Insomnia	7A00-7A0Z	Approved	[49]
Oxazepam	DMXNZM4	Anxiety disorder	6B00-6B0Z	Approved	[50]
Temazepam	DM02A65	Insomnia	7A00-7A0Z	Approved	[4]
Flumazenil	DMPCG2L	Benzodiazepine overdose	PC91	Approved	[51]
Alprazolam	DMC7XDN	Anxiety disorder	6B00-6B0Z	Approved	[49]
Clotiazepam	DM59AZT	Anxiety disorder	6B00-6B0Z	Approved	[52]
Quazepam	DMY4D87	Insomnia	7A00-7A0Z	Approved	[4]
Eszopiclone	DM8RZ9H	Insomnia	7A00-7A0Z	Approved	[53]
Triazolam	DMETYK5	Insomnia	7A00-7A0Z	Approved	[4]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Translocator protein (TSPO)	TTPTXIN	TSPO_HUMAN	Modulator	[4]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)^{Main DME}	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[7]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[8]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[9]
Cytochrome P450 4B1 (CYP4B1)	DEMF740	CP4B1_HUMAN	Substrate	[9]

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References

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