Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMB6871)

• Drug Name: Testosterone enanthate Drug Info
• Synonyms: Testanthate; Testate; Testenate; Testinon; Testoenant; Testonenant; Testosterone 17-enanthate; Testosterone enantate; Testosterone heptanoate; Testosterone heptoate; Testosterone heptylate; Testosterone oenanthate; Testostroval; testosterone enanthate; 17-Hydroxyandrost-4-en-3-one, 17-heptanoate; 315-37-7; Andro L.A. 200; Andropository; Androtardyl; Atlatest; DePatestrye; Delatest; Depo-Testro Med; Ditate; Durathate; Everone; Exten test; Malogen L.A.; Malogen L.A.200; NSC-17591; Orquisteron-E; Primotestone; Reposo TMD; Reposo-TMD
• Cross-matching ID:
  PubChem CID: 9416
  ChEBI ID: CHEBI:9464
  CAS Number: CAS 315-37-7
  TTD Drug ID: DMB6871
  INTEDE Drug ID: DR1565

Molecule-Related Drug Atlas

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[12]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[13]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[15]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[16]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[18]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[19]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[14]

Drug(s) Metabolized By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[14]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[14]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[22]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[14]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[14]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[14]
Metronidazole	DMTIVEN	Abscess		Approved	[23]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[5]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[25]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[26]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[27]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[5]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[28]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[29]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[2]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[30]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[34]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[37]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[4]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[39]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[40]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[41]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[42]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[43]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[44]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[2]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[47]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[49]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[29]

Drug(s) Metabolized By Steroid 5-alpha-reductase 1 (SRD5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[50]
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[7]

Drug(s) Metabolized By Steroid 5-alpha-reductase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[7]

Drug(s) Metabolized By Steroid 5-alpha-reductase 3 (SRD5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[7]

Drug(s) Metabolized By Phosphodiesterase 7B (PDE7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[51]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Protein FAM149A (FAM149A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[64]

Drug(s) Affected By Unconventional myosin-IXa (MYO9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Golgi integral membrane protein 4 (GOLIM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]

Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[83]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[85]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM38 (TRIM38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[88]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[93]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Cocaine esterase (CES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[98]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[99]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[101]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Pyridoxal kinase (PDXK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[108]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[109]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[109]
Fructose	DM43AN2	Vomiting	MD90	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[109]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]

Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[119]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[120]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]

Drug(s) Affected By Protocadherin-17 (PCDH17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[129]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[133]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Secretory carrier-associated membrane protein 1 (SCAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 1B (ARPC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]

Drug(s) Affected By Telethonin (TCAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[140]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[140]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 (INPPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[144]
AMG 176	DM0Q7NO	Acute myeloid leukaemia	2A60	Phase 1	[145]
AZD5991	DM7QGHO	Haematological malignancy	2B33.Y	Phase 1	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Toll-like receptor 3 (TLR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[150]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[151]

Drug(s) Affected By ATP-dependent RNA helicase DDX3Y (DDX3Y)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[152]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[154]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Lysine-specific demethylase 6A (KDM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[133]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[159]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein R (HNRNPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[161]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[162]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Tumor protein D54 (TPD52L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]

Drug(s) Affected By T-box transcription factor TBX1 (TBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[173]

Drug(s) Affected By Trans-Golgi network integral membrane protein 2 (TGOLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[174]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[175]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Phospholipid-transporting ATPase IC (ATP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Indomethacin	DMSC4A7	Bursitis		Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]

Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[183]

Drug(s) Affected By 17S U2 SnRNP complex component HTATSF1 (HTATSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]

Drug(s) Affected By Origin recognition complex subunit 4 (ORC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[186]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[188]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[190]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[192]

Drug(s) Affected By Centrosomal protein of 104 kDa (CEP104)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]

Drug(s) Affected By Beta-1,4-galactosyltransferase 4 (B4GALT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[188]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Monocarboxylate transporter 2 (SLC16A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]

Drug(s) Affected By Cytohesin-interacting protein (CYTIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[198]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[199]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[201]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Protein diaphanous homolog 2 (DIAPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]

Drug(s) Affected By mRNA-capping enzyme (RNGTT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
AT13387	DM2B9E0	Melanoma	2C30	Phase 1	[204]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[53]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[205]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Astrotactin-2 (ASTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Copine-3 (CPNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By CCR4-NOT transcription complex subunit 3 (CNOT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Splicing factor 3B subunit 1 (SF3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]

Drug(s) Affected By 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]

Drug(s) Affected By TIP41-like protein (TIPRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[212]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[213]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[214]

Drug(s) Affected By Scrapie-responsive protein 1 (SCRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Indomethacin	DMSC4A7	Bursitis		Approved	[215]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[64]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By Trafficking protein particle complex subunit 6A (TRAPPC6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[218]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By Multiple PDZ domain protein (MPDZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Ribosomal L1 domain-containing protein 1 (RSL1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By E3 ubiquitin-protein ligase NEURL1 (NEURL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Serine/threonine-protein kinase 10 (STK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By TOX high mobility group box family member 4 (TOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[226]

Drug(s) Affected By PHD finger protein 14 (PHF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[228]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[229]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Actin-binding LIM protein 3 (ABLIM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Rho-related BTB domain-containing protein 3 (RHOBTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[209]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[232]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Ornithine decarboxylase antizyme 2 (OAZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[233]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]

Drug(s) Affected By Luc7-like protein 3 (LUC7L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]

Drug(s) Affected By Methyl-CpG-binding domain protein 4 (MBD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[106]

Drug(s) Affected By Structural maintenance of chromosomes protein 2 (SMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]

Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[237]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[240]

Drug(s) Affected By CCR4-NOT transcription complex subunit 4 (CNOT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[241]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[242]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Synaptosomal-associated protein 29 (SNAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[243]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[244]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[245]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[247]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[256]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[257]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Argininosuccinate synthase (ASS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By Antithrombin-III (SERPINC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[263]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[264]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[265]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[266]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[267]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[269]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[267]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[267]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[270]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[267]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[273]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[274]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[275]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[278]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[281]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[278]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[283]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[283]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[284]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[285]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[286]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[288]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[290]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[293]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[294]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[295]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[299]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[304]

Drug(s) Affected By Complement C1q subcomponent subunit A (C1QA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By Vitamin K-dependent protein C (PROC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[306]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]
Clomipramine	DMINRKW	Depression	6A70-6A7Z	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[309]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[312]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[313]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[316]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[318]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[320]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[321]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[322]

Drug(s) Affected By Lupus La protein (SSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[325]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[117]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[327]

Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[328]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]

Drug(s) Affected By Prothymosin alpha (PTMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[332]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[333]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[334]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[335]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[338]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]

Drug(s) Affected By Vitamin K-dependent protein S (PROS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[266]

Drug(s) Affected By Bifunctional glutamate/proline--tRNA ligase (EPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[78]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[291]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Complement factor H (CFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[344]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[347]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[348]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[349]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[350]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[352]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[353]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[354]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[352]

Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mestranol	DMG3F94	Contraception	QA21	Approved	[355]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[355]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[356]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[357]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[207]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[270]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[359]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]

Drug(s) Affected By Homeobox protein Hox-B7 (HOXB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[360]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[360]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[360]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[360]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[360]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[362]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[364]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[365]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[316]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[369]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[371]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[372]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[373]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[374]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[375]

Drug(s) Affected By Ras-related protein Rap-2a (RAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[376]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[376]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[376]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[377]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[378]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[379]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[380]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[381]
Selenium	DM25CGV	N. A.	N. A.	Approved	[382]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[383]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[386]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Myosin-3 (MYH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]

Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[270]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[389]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[270]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Collagen alpha-2(VI) chain (COL6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[389]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[390]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[392]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[393]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[394]
Cetuximab	DMLNCE0	Colorectal cancer	2B91.Z	Approved	[395]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[397]

Drug(s) Affected By cAMP-dependent protein kinase type II-alpha regulatory subunit (PRKAR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[399]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[247]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[247]

Drug(s) Affected By Perforin-1 (PRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[401]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[288]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[402]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Hematopoietic lineage cell-specific protein (HCLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[404]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[407]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[410]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[413]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[355]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[417]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[418]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[418]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[420]
Bortezomib	DMNO38U	Leukemia		Approved	[421]

Drug(s) Affected By Carbonyl reductase 1 (CBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[423]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[424]

Drug(s) Affected By Ankyrin-1 (ANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[140]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[425]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Solute carrier family 25 member 16 (SLC25A16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[427]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Transmembrane protein 11, mitochondrial (TMEM11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[428]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Homeobox protein Hox-B6 (HOXB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[430]

Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[431]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]

Drug(s) Affected By Endoglin (ENG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[434]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By Leukocyte surface antigen CD53 (CD53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[436]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[437]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[438]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[439]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[440]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[442]

Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[428]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 1 (ATP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[232]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[285]
Cinoxacin	DM4EWNS	Urinary tract infection	GC08	Approved	[285]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[285]
Aztreonam	DMDNJHG	Bacterial infection	1A00-1C4Z	Approved	[285]

Drug(s) Affected By Parvalbumin alpha (PVALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[447]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx2 (MX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[449]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[450]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[452]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Pleiotrophin (PTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[453]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[64]
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[454]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]

Drug(s) Affected By Iduronate 2-sulfatase (IDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[456]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[93]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase B (PPIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase delta (PTPRD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[450]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Endothelin receptor type B (EDNRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[458]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[344]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[459]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[460]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Fructose	DM43AN2	Vomiting	MD90	Approved	[461]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[462]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[463]

Drug(s) Affected By Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[464]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[464]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[464]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[465]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Moesin (MSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[389]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Polypyrimidine tract-binding protein 1 (PTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[466]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[467]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[468]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[469]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[470]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[469]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[471]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Crocin	DM5F24X	N. A.	N. A.	Phase 3	[472]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[81]
OXYBENZONE	DMMZYX6	Discovery agent	N.A.	Investigative	[473]

Drug(s) Affected By Lysine-specific demethylase 5A (KDM5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[474]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[475]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[476]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[477]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[478]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[479]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[476]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[449]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]

Drug(s) Affected By High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[393]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]

Drug(s) Affected By NK-tumor recognition protein (NKTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Homeobox protein Hox-A7 (HOXA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[480]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[481]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[482]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[483]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[484]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[485]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[486]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[487]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[488]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[489]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[490]

Drug(s) Affected By C-C chemokine receptor type 1 (CCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[450]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[491]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[492]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]

Drug(s) Affected By Guanylate-binding protein 2 (GBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By ETS-related transcription factor Elf-1 (ELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[497]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Glypican-1 (GPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[499]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[498]

Drug(s) Affected By Nuclear receptor ROR-alpha (RORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[420]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[119]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[500]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[501]

Drug(s) Affected By Thrombospondin-4 (THBS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[140]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[502]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[503]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[506]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[507]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]

Drug(s) Affected By Protein phosphatase 1A (PPM1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[508]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[421]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[509]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[510]

Drug(s) Affected By V-type proton ATPase catalytic subunit A (ATP6V1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[511]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Interleukin-6 receptor subunit beta (IL6ST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[512]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[513]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[514]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[514]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]

Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[516]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[518]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[87]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[519]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[520]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[521]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[522]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[523]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[524]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[524]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[522]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[522]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[525]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[526]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Biotinidase (BTD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[527]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[528]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Lysophosphatidic acid receptor 6 (LPAR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Chromobox protein homolog 5 (CBX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[529]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[440]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]

Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[530]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[531]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[532]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[533]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[534]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[535]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[144]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[288]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]

Drug(s) Affected By LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[394]

Drug(s) Affected By CD151 antigen (CD151)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[537]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[538]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[144]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[527]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[539]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[540]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[541]

Drug(s) Affected By RNA-binding protein 25 (RBM25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[192]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Bis(5'-adenosyl)-triphosphatase (FHIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[543]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[544]
Methamphetamine	DMPM4SK	Anxiety		Approved	[545]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[546]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[547]

Drug(s) Affected By E3 SUMO-protein ligase RanBP2 (RANBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[394]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[548]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[549]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[550]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[418]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[551]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[553]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[554]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[555]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[394]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Emerin (EMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[557]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[558]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[559]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[560]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[561]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[563]

Drug(s) Affected By RNA-binding protein FXR1 (FXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By RNA-binding protein FXR2 (FXR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[564]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Ras-related protein Rab-27A (RAB27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]

Drug(s) Affected By Lumican (LUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[499]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[404]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[565]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[566]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[522]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[523]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[567]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[568]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[522]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[569]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]

Drug(s) Affected By LIM domain kinase 2 (LIMK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[207]

Drug(s) Affected By E3 ubiquitin-protein ligase TTC3 (TTC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[570]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[571]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[572]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[573]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[573]

Drug(s) Affected By Ephrin type-B receptor 4 (EPHB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[574]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[347]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[575]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[446]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[576]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[577]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[578]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[579]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[580]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[581]

Drug(s) Affected By Puromycin-sensitive aminopeptidase (NPEPPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[582]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]

Drug(s) Affected By Serine/threonine-protein phosphatase 4 catalytic subunit (PPP4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[329]

Drug(s) Affected By Ras-related protein Rab-14 (RAB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]

Drug(s) Affected By Small nuclear ribonucleoprotein E (SNRPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[399]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[435]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[584]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Estrogen-related receptor gamma (ESRRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[585]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[586]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (GNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[587]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[389]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[453]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[288]

Drug(s) Affected By Large ribosomal subunit protein eL30 (RPL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By AP-2 complex subunit beta (AP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[288]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By Small nuclear ribonucleoprotein-associated protein N (SNRPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[589]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]

Drug(s) Affected By Hemoglobin subunit gamma-1 (HBG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]
2-tert-butylbenzene-1,4-diol	DMNXI1E	Discovery agent	N.A.	Investigative	[591]

Drug(s) Affected By Hemoglobin subunit gamma-2 (HBG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[592]
Primaquine	DMWQ16I	Malaria	1F40-1F45	Approved	[592]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[593]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[594]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[595]

Drug(s) Affected By Phosphoserine phosphatase (PSPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[557]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]

Drug(s) Affected By SRSF protein kinase 2 (SRPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[596]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]

Drug(s) Affected By Sushi repeat-containing protein SRPX (SRPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[302]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]

Drug(s) Affected By G-protein-signaling modulator 2 (GPSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[597]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[598]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[599]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By TATA element modulatory factor (TMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Small ribosomal subunit protein bS6m (MRPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By ADAMTS-like protein 3 (ADAMTSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[600]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[119]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[601]

Drug(s) Affected By Phosphatidylinositol transfer protein alpha isoform (PITPNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[602]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]

Drug(s) Affected By Fanconi anemia group C protein (FANCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[453]

Drug(s) Affected By N-acetylgalactosamine kinase (GALK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[186]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[603]

Drug(s) Affected By Myosin light chain 5 (MYL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[603]

Drug(s) Affected By 2-oxoglutarate dehydrogenase complex component E1 (OGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[604]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[399]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[605]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[606]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[474]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[475]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[607]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[608]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[609]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[471]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[610]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[611]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[522]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[523]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[612]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[522]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[522]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[613]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[612]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[522]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[614]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[615]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Collagen alpha-1(XIV) chain (COL14A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[344]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Dermatopontin (DPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[616]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[338]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By Son of sevenless homolog 2 (SOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[338]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By Interleukin-10 receptor subunit beta (IL10RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[491]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[617]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[175]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[144]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[85]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]

Drug(s) Affected By Retinoblastoma-like protein 2 (RBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[618]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[619]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[620]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[621]

Drug(s) Affected By Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[207]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[622]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]

Drug(s) Affected By Nucleosome-remodeling factor subunit BPTF (BPTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[623]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Ankyrin-3 (ANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]

Drug(s) Affected By Striatin-3 (STRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]

Drug(s) Affected By Serine/arginine-rich splicing factor 6 (SRSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Indomethacin	DMSC4A7	Bursitis		Approved	[177]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase G (PPIG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]

Drug(s) Affected By Treacle protein (TCOF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[192]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[615]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[192]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[624]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[626]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[627]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[628]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[629]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[338]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By Neuronal membrane glycoprotein M6-b (GPM6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[630]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[113]

Drug(s) Affected By Phosphatidylinositol-binding clathrin assembly protein (PICALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[499]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[85]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[199]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[631]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[632]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[633]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[634]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]

Drug(s) Affected By Lysosomal-associated transmembrane protein 5 (LAPTM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]

Drug(s) Affected By Activin receptor type-2B (ACVR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[635]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[636]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By cGMP-dependent protein kinase 1 (PRKG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Methamphetamine	DMPM4SK	Anxiety		Approved	[545]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[637]
CP-461	DMEYMTX	Inflammatory bowel disease	DD72	Phase 2	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[53]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[637]

Drug(s) Affected By Malectin (MLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Elongin-A (ELOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[638]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]

Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[270]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[270]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[639]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[270]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[640]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[641]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]

Drug(s) Affected By ATP-sensitive inward rectifier potassium channel 12 (KCNJ12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Max dimerization protein 4 (MXD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[598]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[238]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[218]

Drug(s) Affected By Bridge-like lipid transfer protein family member 2 (BLTP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[53]

Drug(s) Affected By Disco-interacting protein 2 homolog A (DIP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[53]

Drug(s) Affected By Sarcospan (SSPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[116]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 1 (LTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[642]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[643]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]

Drug(s) Affected By Importin subunit beta-1 (KPNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[644]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[644]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]

Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Squamous cell carcinoma antigen recognized by T-cells 3 (SART3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]

Drug(s) Affected By Phosphomevalonate kinase (PMVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[645]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[646]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Serine/threonine-protein kinase 38 (STK38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[450]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[554]

Drug(s) Affected By Retinoblastoma-binding protein 5 (RBBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[475]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[450]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[647]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Angiopoietin-1 (ANGPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[648]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[649]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[449]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 7 (PPP1R7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By Protein transport protein Sec23B (SEC23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Regucalcin (RGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Coiled-coil domain-containing protein 85B (CCDC85B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[650]

Drug(s) Affected By Laminin subunit alpha-4 (LAMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[651]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[87]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[87]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[652]

Drug(s) Affected By U11/U12 small nuclear ribonucleoprotein 35 kDa protein (SNRNP35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[653]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[654]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[655]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[87]

Drug(s) Affected By Gamma-interferon-inducible protein 16 (IFI16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3A (PPP1R3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[656]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[656]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[656]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]

Drug(s) Affected By Hyaluronidase-4 (HYAL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[481]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]

Drug(s) Affected By PWWP domain-containing DNA repair factor 3A (PWWP3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Protein-glucosylgalactosylhydroxylysine glucosidase (PGGHG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[657]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Angiomotin (AMOT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[81]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Membralin (TMEM259)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[226]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[658]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[659]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[658]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[660]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[658]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]

Drug(s) Affected By BCL-6 corepressor-like protein 1 (BCORL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[527]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]

Drug(s) Affected By Myomegalin (PDE4DIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[180]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[661]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[180]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[662]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]

Drug(s) Affected By Muscleblind-like protein 2 (MBNL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Activity-dependent neuroprotector homeobox protein 2 (ADNP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[172]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[663]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[664]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[329]

Drug(s) Affected By 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Caveolae-associated protein 1 (CAVIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[389]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]

Drug(s) Affected By Endoplasmic reticulum aminopeptidase 2 (ERAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Volume-regulated anion channel subunit LRRC8B (LRRC8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[666]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[667]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[667]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]

Drug(s) Affected By Teashirt homolog 1 (TSHZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Protein RUFY3 (RUFY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[615]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By TLR4 interactor with leucine rich repeats (TRIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[216]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[53]

Drug(s) Affected By ATP-dependent RNA helicase DHX29 (DHX29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[558]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[668]

Drug(s) Affected By Calmodulin-lysine N-methyltransferase (CAMKMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[65]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Reticulophagy regulator 3 (RETREG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Centrosomal protein of 57 kDa (CEP57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[669]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[670]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Homeodomain-interacting protein kinase 1 (HIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By ELKS/Rab6-interacting/CAST family member 1 (ERC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Glucose-induced degradation protein 4 homolog (GID4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[584]

Drug(s) Affected By SURP and G-patch domain-containing protein 2 (SUGP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Structural maintenance of chromosomes protein 5 (SMC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[105]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[671]

Drug(s) Affected By Threonine synthase-like 1 (THNSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Solute carrier family 38 member 6 (SLC38A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[427]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA7 (ABCA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[427]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[673]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Angiogenic factor with G patch and FHA domains 1 (AGGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[394]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By EH domain-binding protein 1-like protein 1 (EHBP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[213]

Drug(s) Affected By N(6)-adenine-specific methyltransferase METTL4 (METTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[674]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By GTP-binding protein 8 (GTPBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By ER membrane protein complex subunit 1 (EMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[675]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[676]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By NFATC2-interacting protein (NFATC2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[677]

Drug(s) Affected By Protein NDNF (NDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By DnaJ homolog subfamily B member 14 (DNAJB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[677]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Coiled-coil alpha-helical rod protein 1 (CCHCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[64]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[678]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Methamphetamine	DMPM4SK	Anxiety		Approved	[545]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[679]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[427]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[680]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[681]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[517]

Drug(s) Affected By Elongator complex protein 5 (ELP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By Partitioning defective 3 homolog (PARD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[458]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[458]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[458]

Drug(s) Affected By Protein prune homolog 2 (PRUNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[627]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[446]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]

Drug(s) Affected By Pentatricopeptide repeat-containing protein 2, mitochondrial (PTCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[201]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[81]

Drug(s) Affected By Uncharacterized protein C1orf54 (C1ORF54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[372]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]

Drug(s) Affected By Cytoskeleton-associated protein 2 (CKAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[354]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Palladin (PALLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[682]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[623]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 13 (ASB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[219]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[584]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[242]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[683]

Drug(s) Affected By HMG box transcription factor BBX (BBX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[207]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[207]

Drug(s) Affected By C-type lectin domain family 2 member B (CLEC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[589]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[394]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[213]

Drug(s) Affected By SEC14-like protein 1 (SEC14L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[207]

Drug(s) Affected By PHD finger protein 3 (PHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[446]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[192]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[684]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Tetratricopeptide repeat protein 9A (TTC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[425]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Peroxidasin homolog (PXDN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[430]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[685]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[499]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Small ribosomal subunit protein mS31 (MRPS31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[686]

Drug(s) Affected By Secreted frizzled-related protein 3 (FRZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[391]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[430]

Drug(s) Affected By Prospero homeobox protein 1 (PROX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[687]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Endoplasmic reticulum protein SC65 (P3H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[688]

Drug(s) Affected By NEDD4-binding protein 2-like 2 (N4BP2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[615]

Drug(s) Affected By Golgin subfamily A member 1 (GOLGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[689]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[690]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Golgi apparatus protein 1 (GLG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By BLOC-3 complex member HPS1 (HPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[661]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Exostosin-like 1 (EXTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[573]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[573]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Transportin-1 (TNPO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[691]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[692]

Drug(s) Affected By Cullin-5 (CUL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[693]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[476]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[694]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Sodium-coupled neutral amino acid transporter 4 (SLC38A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[427]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[197]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[85]

Drug(s) Affected By Protein lifeguard 3 (TMBIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[93]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[93]

Drug(s) Affected By Fermitin family homolog 2 (FERMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[203]

Drug(s) Affected By Clusterin-associated protein 1 (CLUAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[584]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[695]

Drug(s) Affected By Lipid droplet assembly factor 1 (LDAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[355]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mestranol	DMG3F94	Contraception	QA21	Approved	[355]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[355]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By FAS-associated factor 2 (FAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 8 (MED8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[696]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[696]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[214]

Drug(s) Affected By RNA-binding protein 41 (RBM41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[178]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[697]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[178]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Serine/Arginine-related protein 53 (RSRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[662]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[677]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[117]

Drug(s) Affected By Serine/threonine-protein kinase Nek1 (NEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]

Drug(s) Affected By Serine/threonine-protein kinase SMG1 (SMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[671]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[698]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[699]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[671]

Drug(s) Affected By Msx2-interacting protein (SPEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[700]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Flavin-containing monooxygenase 2 (FMO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[701]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[701]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[702]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[703]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28454500-Compound-96	DM2A75P	N. A.	N. A.	Patented	[701]

Drug(s) Affected By M-phase phosphoprotein 9 (MPHOSPH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[85]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[238]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By Protein SCAF11 (SCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[133]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[192]

Drug(s) Affected By DnaJ homolog subfamily C member 7 (DNAJC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By Fasciculation and elongation protein zeta-1 (FEZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[704]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[705]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[705]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Mothers against decapentaplegic homolog 5 (SMAD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[630]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[635]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[706]

Drug(s) Affected By Ribosome quality control complex subunit TCF25 (TCF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[238]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[603]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[238]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[707]

Drug(s) Affected By Hephaestin (HEPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[207]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Deubiquitinase DESI2 (DESI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[588]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 4 (DHRS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[276]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By TIMELESS-interacting protein (TIPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[86]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]

Drug(s) Affected By Sideroflexin-3 (SFXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[440]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]

Drug(s) Affected By N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Asporin (ASPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[499]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[128]

Drug(s) Affected By Oxysterol-binding protein-related protein 8 (OSBPL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[692]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]

Drug(s) Affected By Apoptosis inhibitor 5 (API5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[346]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[708]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[709]

Drug(s) Affected By Brain-specific serine protease 4 (PRSS22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[676]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[710]

Drug(s) Affected By ATP-dependent RNA helicase DDX24 (DDX24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[711]

Drug(s) Affected By Ankyrin repeat domain-containing protein 2 (ANKRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[216]

Drug(s) Affected By Golgi resident protein GCP60 (ACBD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[603]

Drug(s) Affected By Kinetochore-associated protein DSN1 homolog (DSN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[354]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]

Drug(s) Affected By Torsin-3A (TOR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[712]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]

Drug(s) Affected By ESF1 homolog (ESF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[676]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Protein ECT2 (ECT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[527]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Protein argonaute-3 (AGO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 1 (PLEKHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]

Drug(s) Affected By Retinoid-inducible serine carboxypeptidase (SCPEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Sp110 nuclear body protein (SP110)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[478]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By E3 ubiquitin-protein ligase MSL2 (MSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 8 (CHD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[713]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[714]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
Chlorphrifos oxon	DMGBT68	Discovery agent	N.A.	Investigative	[715]
CHLORPYRIFOS	DMKPUI6	Discovery agent	N.A.	Investigative	[715]

Drug(s) Affected By DnaJ homolog subfamily C member 4 (DNAJC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Indomethacin	DMSC4A7	Bursitis		Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[716]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[717]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[718]

Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[113]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[696]

Drug(s) Affected By Suppressor of tumorigenicity 7 protein (ST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[207]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[207]

Drug(s) Affected By Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Indomethacin	DMSC4A7	Bursitis		Approved	[177]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[719]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Latent-transforming growth factor beta-binding protein 3 (LTBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[64]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[213]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By BMP-2-inducible protein kinase (BMP2K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Indomethacin	DMSC4A7	Bursitis		Approved	[177]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Nucleotide sugar transporter SLC35D1 (SLC35D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[427]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Guanine nucleotide-binding protein-like 3-like protein (GNL3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[720]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[455]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[193]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[721]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By Opioid growth factor receptor (OGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[527]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]

Drug(s) Affected By Cysteine-rich motor neuron 1 protein (CRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[156]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[667]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]

Drug(s) Affected By ]-phosphatase 1, mitochondrial (PDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Indomethacin	DMSC4A7	Bursitis		Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[211]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]

Drug(s) Affected By Ribosome-binding protein 1 (RRBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[722]

Drug(s) Affected By Serine/threonine-protein kinase NLK (NLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Dickkopf-related protein 2 (DKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[141]
Indomethacin	DMSC4A7	Bursitis		Approved	[723]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[641]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[425]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Armadillo repeat-containing X-linked protein 3 (ARMCX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[724]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[85]

Drug(s) Affected By F-box only protein 40 (FBXO40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[76]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[725]

Drug(s) Affected By Prenylcysteine oxidase 1 (PCYOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Anaphase-promoting complex subunit 5 (ANAPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[714]

Drug(s) Affected By G patch domain-containing protein 8 (GPATCH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[277]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[668]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 21 (ADAM21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[173]

Drug(s) Affected By Integrator complex subunit 6 (INTS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[440]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[155]

Drug(s) Affected By BAG family molecular chaperone regulator 5 (BAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[726]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[727]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[178]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[206]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Microtubule-associated tumor suppressor 1 (MTUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[128]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]

Drug(s) Affected By Neurabin-1 (PPP1R9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[728]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[232]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Serine/arginine repetitive matrix protein 2 (SRRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[158]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[542]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[107]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[453]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[394]

Drug(s) Affected By PALM2-AKAP2 fusion protein (PALM2AKAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[449]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[436]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Epididymis-specific alpha-mannosidase (MAN2B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[404]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[138]

Drug(s) Affected By Ribosomal RNA-processing protein 7 homolog A (RRP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[471]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[218]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[163]

Drug(s) Affected By TRPM8 channel-associated factor 1 (TCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Haloperidol	DM96SE0	Delirium		Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[194]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By Rap guanine nucleotide exchange factor 2 (RAPGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[53]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[130]

Drug(s) Affected By Lysyl oxidase homolog 2 (LOXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[729]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[730]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[329]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[630]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]

Drug(s) Affected By AP-4 complex subunit sigma-1 (AP4S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[224]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[731]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[126]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[64]

Drug(s) Affected By RNA polymerase II subunit A C-terminal domain phosphatase (CTDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Transportin-3 (TNPO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[329]

Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[732]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[365]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Sodium bicarbonate cotransporter 3 (SLC4A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]

Drug(s) Affected By Calpain-6 (CAPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Indomethacin	DMSC4A7	Bursitis		Approved	[723]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[643]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[641]

Drug(s) Affected By Nuclear receptor coactivator 3 (NCOA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[733]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By SEC23-interacting protein (SEC23IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[80]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[130]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[1]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[2]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[3]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[4]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[5]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Substrate	[6]
Steroid 5-alpha-reductase 2 (SRD5A2)	DEPTJ3D	S5A2_HUMAN	Substrate	[7]
Phosphodiesterase 7B (PDE7B)	DEON3ED	PDE7B_HUMAN	Substrate	[8]
Steroid 5-alpha-reductase 3 (SRD5A3)	DEZGVDW	PORED_HUMAN	Substrate	[7]
Steroid 5-alpha-reductase 1 (SRD5A1)	DEOG15F	S5A1_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[9]
17S U2 SnRNP complex component HTATSF1 (HTATSF1)	OTLQ1ZLS	HTSF1_HUMAN	Gene/Protein Processing	[9]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[9]
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial (GCAT)	OT6WZPWV	KBL_HUMAN	Gene/Protein Processing	[9]
2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 (OGFOD2)	OTTXP61X	OGFD2_HUMAN	Gene/Protein Processing	[9]
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Gene/Protein Processing	[9]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)	OTK3SHT2	PDE7B_HUMAN	Biotransformations	[10]
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial (HIBCH)	OTU2VHWR	HIBCH_HUMAN	Gene/Protein Processing	[9]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Gene/Protein Processing	[9]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)	OTLVN68B	AAKB2_HUMAN	Gene/Protein Processing	[9]

References

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