Details of Disease

General Information of Disease (ID: DIS0SVD1)

Disease Name Obstructive sleep apnea
Synonyms
sleep apnea/hypopnea syndrome; sleep apnea hypopnea syndrome; sleep apnea syndrome, obstructive; sleep Apneas, obstructive; Osa; syndrome, upper airway resistance, sleep apnea; obstructive sleep Apneas; syndrome, obstructive sleep apnea; upper airway resistance sleep apnea syndrome; syndrome, sleep apnea, obstructive; apnea, obstructive sleep; Apneas, obstructive sleep; OSAHS; obstructive sleep apnea syndrome; obstructive sleep apnea
Disease Class 7A41: Obstructive sleep apnoea
Definition Cessation of air flow during sleep due to upper airway obstruction.
Disease Hierarchy
DIS6SVEE: Syndromic disease
DISER6KS: Sleep apnea syndrome
DIS0SVD1: Obstructive sleep apnea
ICD Code
ICD-11
ICD-11: 7A41
ICD-9
ICD-9: 327.23, 780.57
Expand ICD-11
'7A41
Expand ICD-9
327.23,780.57
Disease Identifiers
MONDO ID
MONDO_0007147
MESH ID
D020181
UMLS CUI
C0520679
OMIM ID
107650
MedGen ID
101045
HPO ID
HP:0002870
SNOMED CT ID
78275009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Dexmedetomidine DM93L4X Approved Small molecular drug [1]
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This Disease is Treated as An Indication in 4 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BAY 2253651 DM450XS Phase 2 Small molecular drug [2]
BAY-2253651 DMM7Q68 Phase 2 NA [3]
CX1789 DMA5D6T Phase 2 NA [4]
AVE0118 DMSR91U Phase 1 Small molecular drug [5]
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This Disease is Treated as An Indication in 2 Discontinued Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
BGC-20-0166 DM6GDNP Discontinued in Phase 2 NA [6]
SEP-226332 DMCQI25 Discontinued in Phase 1 NA [7]
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This Disease is Treated as An Indication in 3 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
CX-1942 DMYP1J0 Investigative NA [8]
GALL-200 DM8J53P Investigative NA [8]
PPI-03306 DM7XGSY Investigative NA [8]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 56 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
TXN TTZJ5U9 Disputed Biomarker [9]
ABCB1 TT3OT40 Strong Biomarker [10]
ADAMTS4 TTYG6BU Strong Biomarker [11]
ADIPOQ TTXKA7D Strong Genetic Variation [12]
ADORA1 TTK25J1 Strong Biomarker [13]
ADRB3 TTMXGCW Strong Genetic Variation [14]
APOH TT2OUI9 Strong Biomarker [15]
ARRB1 TTMVD4A Strong Genetic Variation [16]
ARSA TTYQANR Strong Biomarker [17]
BMP2 TTP3IGX Strong Biomarker [18]
CAD TT2YT1K Strong Biomarker [19]
CD160 TTOFEAS Strong Biomarker [20]
CHIT1 TTDYX6T Strong Altered Expression [21]
CRY1 TT5MLZR Strong Biomarker [22]
CRY2 TTAO58M Strong Biomarker [23]
CSPG4 TT7MYXI Strong Altered Expression [24]
EDN1 TTJR60Z Strong Altered Expression [25]
EDNRA TTKRD0G Strong Biomarker [26]
FABP4 TTHWMFZ Strong Altered Expression [27]
FFAR4 TT08JVB Strong Altered Expression [28]
FPR1 TT5Y4EM Strong Altered Expression [29]
FPR3 TT16TM5 Strong Altered Expression [29]
GAP43 TTSGLN5 Strong Biomarker [30]
GHRL TT1OCL0 Strong Biomarker [31]
GHSR TTWDC17 Strong Biomarker [31]
GJA5 TTFQKZ7 Strong Biomarker [32]
GPD1 TTKTEAH Strong Altered Expression [33]
HAL TTXQOZW Strong Genetic Variation [34]
IL1R2 TT51DEV Strong Biomarker [35]
KCNJ1 TTJ13ST Strong Biomarker [36]
KCNJ2 TTH7UO3 Strong Genetic Variation [37]
KCNK3 TTGR91N Strong Genetic Variation [36]
LBP TTVQJLY Strong Biomarker [38]
LRRC32 TT0FAYT Strong Altered Expression [39]
MC4R TTD0CIQ Strong Biomarker [40]
MYH7 TTNIMDP Strong Altered Expression [41]
NPR2 TTNB7IF Strong Biomarker [35]
NPR3 TTWVLS6 Strong Genetic Variation [42]
NR3C2 TT26PHO Strong Biomarker [43]
NT5E TTK0O6Y Strong Biomarker [44]
PLCB1 TTLPGU7 Strong Genetic Variation [16]
PNMT TT0NZIC Strong Biomarker [45]
PPARGC1B TTKSQ3W Strong Genetic Variation [46]
PTGER3 TTPNGDE Strong Genetic Variation [47]
REN TTB2MXP Strong Altered Expression [48]
RHAG TTVHFE8 Strong Biomarker [49]
RNMT TTG45HY Strong Genetic Variation [50]
SENP1 TTW9HY5 Strong Biomarker [51]
SLC18A3 TTV8KWS Strong Biomarker [52]
SLC6A4 TT3ROYC Strong Genetic Variation [53]
SNAP25 TTYQWA0 Strong Biomarker [54]
SNCG TT5TQNZ Strong Altered Expression [55]
TPO TT52XDZ Strong Biomarker [56]
HCRT TTU5HJP Definitive Altered Expression [57]
REG3A TTL4H8N Definitive Biomarker [58]
TUSC2 TTJ8O14 Definitive Biomarker [58]
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⏷ Show the Full List of 56 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCC11 DTWN7FC Strong Biomarker [59]
SLC25A20 DTQOUM4 Strong Biomarker [60]
SLC35A2 DT0567K Strong Genetic Variation [61]
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This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ACP5 DESITDW Strong Altered Expression [62]
ACSS2 DEE76VW Strong Biomarker [63]
GPT DER5HFI Strong Altered Expression [64]
PER1 DE9HF0I Strong Biomarker [23]
SULT1A3 DEP7E8X Strong Altered Expression [65]
ACP3 DEDW5H6 Definitive Biomarker [58]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 85 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CHI3L1 OT2Z7VJH Disputed Biomarker [66]
DECR1 OTCDIR6X Disputed Biomarker [67]
ABI1 OT5H4M62 Strong Altered Expression [68]
ACCS OTHIHI9D Strong Biomarker [63]
ADAM22 OT452ZDC Strong Genetic Variation [69]
ADAM29 OTGLTTKU Strong Altered Expression [52]
AHSP OTTHBSUS Strong Biomarker [70]
ALDOA OTWRFTIB Strong Altered Expression [65]
AMY1A OT6G4B8O Strong Biomarker [71]
ANGPTL8 OTQFINCD Strong Altered Expression [72]
APOA5 OTEVKLVA Strong Biomarker [73]
APOM OTI3FQQC Strong Biomarker [73]
ARID1B OTILK3Q7 Strong Biomarker [74]
ATP6AP2 OT0IABVV Strong Altered Expression [75]
BGLAP OTK1YLWQ Strong Altered Expression [76]
C1QTNF9 OTLI3VA3 Strong Biomarker [77]
CAPN10 OTS9LJW4 Strong Genetic Variation [78]
CCHCR1 OT22C116 Strong Genetic Variation [79]
CDH4 OT8LH3HN Strong Genetic Variation [16]
CEBPZ OT11BATG Strong Biomarker [80]
CFAP97 OT0RSQO4 Strong Altered Expression [81]
CHGA OTXYX5JH Strong Biomarker [82]
CHP1 OTHTXN1A Strong Genetic Variation [83]
DBP OTE0W7LN Strong Genetic Variation [42]
DCD OTV5PBGJ Strong Biomarker [84]
DCTN3 OTQOSUES Strong Genetic Variation [83]
DMP1 OTBWBWW7 Strong Altered Expression [85]
DNAJC5 OTCZDXAL Strong Biomarker [86]
DYM OTQ670WI Strong Biomarker [87]
DYNC1H1 OTD1KRKO Strong Genetic Variation [83]
ENHO OT91QASK Strong Biomarker [88]
ESM1 OT331Y8V Strong Biomarker [89]
ETV3 OTEN03BM Strong Biomarker [90]
FASTK OTTHFZMP Strong Biomarker [81]
FLNC OT3F8J6Y Strong Altered Expression [91]
FLRT2 OTGD8TID Strong Biomarker [52]
GABBR1 OTU5A52J Strong Genetic Variation [92]
HERPUD1 OT9EROL6 Strong Biomarker [54]
KCNMB1 OTO4KNJ4 Strong Biomarker [93]
LTBP3 OTME98V7 Strong Biomarker [94]
MAN1C1 OT44TM7D Strong Biomarker [95]
MAP6 OTPUI00F Strong Genetic Variation [96]
MAP9 OTZD5099 Strong Biomarker [97]
MCIDAS OTK1JVAH Strong Genetic Variation [98]
MEOX2 OTKZCJCB Strong Altered Expression [99]
MGP OTZWU3FU Strong Biomarker [100]
MMD OTB5I4OC Strong Biomarker [19]
NANOS1 OT3UNZZY Strong Genetic Variation [101]
NANS OTMQ2FUH Strong Biomarker [102]
NBL1 OTT37U4O Strong Altered Expression [103]
NGB OTW0SIUY Strong Biomarker [22]
NPS OTEG25A2 Strong Genetic Variation [104]
OPN4 OT1LZ7TS Strong Biomarker [105]
PANX1 OTXPEDOK Strong Biomarker [106]
PHB2 OTCAX3AW Strong Genetic Variation [83]
PHOX2B OT3SFR2O Strong Biomarker [107]
PITX3 OTE2KT8P Strong Altered Expression [108]
PLA2G15 OT6VJTPA Strong Biomarker [63]
PLEK OTB73XXA Strong Genetic Variation [47]
POU2AF1 OTOO6WHL Strong Altered Expression [109]
PRB1 OTV0SYMD Strong Biomarker [110]
PSG5 OTHTU98X Strong Biomarker [111]
PSPH OTV1PVAX Strong Altered Expression [112]
RAI1 OTKLQU00 Strong Biomarker [113]
REM1 OTUXL0HC Strong Biomarker [114]
RNASE2 OT8Z4FNE Strong Biomarker [101]
SELENBP1 OT3NZNTR Strong Genetic Variation [79]
SERPINA12 OTS1E6IP Strong Biomarker [115]
SESN2 OT889IXY Strong Biomarker [116]
SFTPC OTIZJD09 Strong Altered Expression [117]
SGCD OTRBL3NQ Strong Genetic Variation [118]
SMCO2 OT1NVQGP Strong Genetic Variation [16]
SNCB OTELSEK6 Strong Altered Expression [55]
SOX21 OTNT50CC Strong Biomarker [119]
SP140 OTQZHFMT Strong Biomarker [35]
SRI OT4R3EAC Strong Biomarker [120]
TSPAN18 OTHSGPVB Strong Genetic Variation [16]
TSPAN31 OT8WQ83R Strong Biomarker [102]
ASAP1 OT4DLRYY Definitive Biomarker [58]
ASAP2 OTGEXULW Definitive Biomarker [58]
CLOCK OTNEOJY7 Definitive Genetic Variation [23]
MRPS30 OTDXIAGG Definitive Biomarker [58]
MTPAP OT6HQ02S Definitive Biomarker [58]
PAPOLA OTPHD65D Definitive Biomarker [58]
PDAP1 OTJSWMOD Definitive Biomarker [58]
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⏷ Show the Full List of 85 DOT(s)

References

1 Dexmedetomidine FDA Label
2 ClinicalTrials.gov (NCT03603678) Obstructive Sleep Apnea (OSA) Treated With a Potassium Channel Inhibitor (SANDMAN). U.S. National Institutes of Health.
3 Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800019047)
6 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800023354)
7 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800020129)
8 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
9 Bioinformatics analysis to reveal the key genes related to obstructive sleep apnea.Sleep Breath. 2019 Mar;23(1):259-267. doi: 10.1007/s11325-018-1694-7. Epub 2018 Jul 10.
10 Influence of intermittent hypoxia on myocardial and hepatic P-glycoprotein expression in a rodent model.Pharmacotherapy. 2009 Apr;29(4):365-72. doi: 10.1592/phco.29.4.365.
11 Association between the ADAMTS proteinases and obstructive sleep apnea.Sleep Breath. 2020 Sep;24(3):835-840. doi: 10.1007/s11325-019-01909-0. Epub 2019 Aug 16.
12 Targeted sequencing analysis of the adiponectin gene identifies variants associated with obstructive sleep apnoea in Chinese Han population.Medicine (Baltimore). 2019 Apr;98(16):e15219. doi: 10.1097/MD.0000000000015219.
13 Activating adenosine A1 receptor accelerates PC12 cell injury via ADORA1/PKC/KATP pathway after intermittent hypoxia exposure.Mol Cell Biochem. 2018 Sep;446(1-2):161-170. doi: 10.1007/s11010-018-3283-2. Epub 2018 Jan 29.
14 beta3-Adrenergic receptor Trp64Arg polymorphism and increased body mass index in sleep apnoea.Eur Respir J. 2007 Oct;30(4):743-7. doi: 10.1183/09031936.00152006. Epub 2007 Jul 11.
15 Relation between serum leptin levels, lipid profiles and neurocognitive deficits in Chinese OSAHS patients.Int J Neurosci. 2017 Nov;127(11):981-987. doi: 10.1080/00207454.2017.1286654. Epub 2017 Feb 13.
16 Genetic Associations with Obstructive Sleep Apnea Traits in Hispanic/Latino Americans.Am J Respir Crit Care Med. 2016 Oct 1;194(7):886-897. doi: 10.1164/rccm.201512-2431OC.
17 Nasal positive pressure with the SuperNO(2)VA?device decreases sedation-related hypoxemia during pre-bariatric surgery EGD.Surg Endosc. 2019 Nov;33(11):3828-3832. doi: 10.1007/s00464-019-06721-1. Epub 2019 Feb 25.
18 BMP-2 inhibits lung metastasis of osteosarcoma: an early investigation using an orthotopic model.Onco Targets Ther. 2018 Oct 29;11:7543-7553. doi: 10.2147/OTT.S176724. eCollection 2018.
19 Use of CAD-CAM technology to improve orthognathic surgeryoutcomes in patients with severe obstructive sleep apnoea syndrome.J Craniomaxillofac Surg. 2019 Sep;47(9):1331-1337. doi: 10.1016/j.jcms.2019.06.010. Epub 2019 Jun 25.
20 Neurotrophins and tonsillar hypertrophy in children with obstructive sleep apnea.Pediatr Res. 2007 Oct;62(4):489-94. doi: 10.1203/PDR.0b013e31814257ed.
21 Obesity modulates the association between sleep apnea treatment and CHI3L1 levels but not CHIT1 activity in moderate to severe OSA: an observational study.Sleep Breath. 2018 Dec;22(4):1101-1109. doi: 10.1007/s11325-018-1731-6. Epub 2018 Oct 11.
22 Neuroglobin correlates with cryptochrome-1 in obstructive sleep apnea with primary aldosteronism.PLoS One. 2018 Sep 20;13(9):e0204390. doi: 10.1371/journal.pone.0204390. eCollection 2018.
23 Alternations of Circadian Clock Genes Expression and Oscillation in Obstructive Sleep Apnea.J Clin Med. 2019 Oct 6;8(10):1634. doi: 10.3390/jcm8101634.
24 Identification of CSPG4 as a promising target for translational combinatorial approaches in osteosarcoma.Ther Adv Med Oncol. 2019 Jun 6;11:1758835919855491. doi: 10.1177/1758835919855491. eCollection 2019.
25 Effect of continuous positive airway pressure on endothelin-1 in patients with obstructive sleep apnea: a meta-analysis.Eur Arch Otorhinolaryngol. 2019 Mar;276(3):623-630. doi: 10.1007/s00405-018-5225-8. Epub 2018 Dec 3.
26 Blockade of Endothelin-1 Receptor Type B Ameliorates Glucose Intolerance and Insulin Resistance in a Mouse Model of Obstructive Sleep Apnea.Front Endocrinol (Lausanne). 2018 May 29;9:280. doi: 10.3389/fendo.2018.00280. eCollection 2018.
27 Circulating adipocyte fatty acid-binding protein is reduced by continuous positive airway pressure treatment for obstructive sleep apnea-a randomized controlled study.Sleep Breath. 2020 Sep;24(3):817-824. doi: 10.1007/s11325-019-01893-5. Epub 2019 Aug 1.
28 Obstructive sleep apnea and obesity are associated with reduced GPR 120 plasma levels in children.Sleep. 2014 May 1;37(5):935-41. doi: 10.5665/sleep.3664.
29 Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients.PLoS One. 2019 May 22;14(5):e0216607. doi: 10.1371/journal.pone.0216607. eCollection 2019.
30 Chronic obstructive sleep apnea promotes aortic remodeling in canines through miR-145/Smad3 signaling pathway.Oncotarget. 2017 Jun 6;8(23):37705-37716. doi: 10.18632/oncotarget.17144.
31 Orexin Plays a Role in Growth Impediment Induced by Obstructive Sleep Breathing in Rats.Sleep. 2016 Apr 1;39(4):887-97. doi: 10.5665/sleep.5648.
32 Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins.BMC Cell Biol. 2017 Jan 17;18(Suppl 1):7. doi: 10.1186/s12860-016-0117-5.
33 The influence of obstructive sleep apnea on the expression of glycerol-3-phosphate dehydrogenase 1 gene.Exp Biol Med (Maywood). 2010 Jan;235(1):52-6. doi: 10.1258/ebm.2009.009150.
34 A Single Nucleotide Polymorphism (rs1056629) in 3'-UTR of MMP-9 is Responsible for a Decreased Risk of Metastatic Osteosarcoma by Compromising its Interaction with microRNA-491-5p. Cell Physiol Biochem. 2016;38(4):1415-24.
35 Whole Genome DNA Methylation Analysis of Obstructive Sleep Apnea: IL1R2, NPR2, AR, SP140 Methylation and Clinical Phenotype.Sleep. 2016 Apr 1;39(4):743-55. doi: 10.5665/sleep.5620.
36 Genetic variants of rs1275988 and rs2586886 in TWIK-related acid-sensitive K+ channel-1 gene may be potential risk factors for obese patients with obstructive sleep apnea.Chin Med J (Engl). 2019 Sep 5;132(17):2059-2065. doi: 10.1097/CM9.0000000000000401.
37 Andersen syndrome: an association of periodic paralysis, cardiac arrhythmia and dysmorphic abnormalities.Arq Neuropsiquiatr. 2006 Sep;64(3A):582-4. doi: 10.1590/s0004-282x2006000400009.
38 Circulating lipopolysaccharide-binding protein and carotid intima-media thickness in obstructive sleep apnea.Physiol Res. 2018 Mar 16;67(1):69-78. doi: 10.33549/physiolres.933632. Epub 2017 Nov 10.
39 Monocytes inhibit NK activity via TGF- in patients with obstructive sleep apnoea.Eur Respir J. 2017 Jun 15;49(6):1602456. doi: 10.1183/13993003.02456-2016. Print 2017 Jun.
40 Severe obstructive sleep apnea in a child with melanocortin-4 receptor deficiency.J Clin Sleep Med. 2014 Jan 15;10(1):99-101. doi: 10.5664/jcsm.3374.
41 Estrogen/ERR- signaling axis is associated with fiber-type conversion of upper airway muscles in patients with obstructive sleep apnea hypopnea syndrome.Sci Rep. 2016 Jun 2;6:27088. doi: 10.1038/srep27088.
42 Association of JAG1 gene polymorphism with systemic blood pressure in patients with obstructive sleep apnea: a prospective cohort study.Croat Med J. 2019 Oct 31;60(5):421-430. doi: 10.3325/cmj.2019.60.421.
43 Role of Mineralocorticoid Receptors in Obstructive Sleep Apnea and Metabolic Syndrome.Curr Hypertens Rep. 2018 Mar 19;20(3):23. doi: 10.1007/s11906-018-0819-5.
44 Respiratory polygraphy in children: Feasibility in everyday practice in an ENT department and value of automatic detection of respiratory events.Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Sep;136(4):235-240. doi: 10.1016/j.anorl.2019.03.001. Epub 2019 Mar 14.
45 Phenylethanolamine N-methyltransferase gene expression in PC12 cells exposed to intermittent hypoxia.Neurosci Lett. 2018 Feb 14;666:169-174. doi: 10.1016/j.neulet.2017.12.056. Epub 2017 Dec 27.
46 Genetic variants associated with sleep disorders.Sleep Med. 2015 Feb;16(2):217-24. doi: 10.1016/j.sleep.2014.11.003. Epub 2014 Dec 5.
47 Association of genetic loci with sleep apnea in European Americans and African-Americans: the Candidate Gene Association Resource (CARe).PLoS One. 2012;7(11):e48836. doi: 10.1371/journal.pone.0048836. Epub 2012 Nov 14.
48 Sex differences in renal hemodynamics and renin-angiotensin system activity post-CPAP therapy in humans with obstructive sleep apnea.Am J Physiol Renal Physiol. 2020 Jan 1;318(1):F25-F34. doi: 10.1152/ajprenal.00290.2019. Epub 2019 Oct 14.
49 Ultrasonographic measurement of the diaphragm thickness in patients with obstructive sleep apnea syndrome.Sleep Breath. 2020 Mar;24(1):89-94. doi: 10.1007/s11325-019-01931-2. Epub 2019 Aug 28.
50 Sleep disorders in Charcot-Marie-Tooth disease type 1.J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):319-25. doi: 10.1136/jnnp-2013-305296. Epub 2013 May 23.
51 SENP1-mediated NEMO de-SUMOylation inhibits intermittent hypoxia induced inflammatory response of microglia in vitro.J Cell Physiol. 2020 Apr;235(4):3529-3538. doi: 10.1002/jcp.29241. Epub 2019 Sep 24.
52 Gene expression profiles in peripheral blood mononuclear cells of Asian obstructive sleep apnea patients.Biomed J. 2014 Mar-Apr;37(2):60-70. doi: 10.4103/2319-4170.113188.
53 Obstructive sleep apnea syndrome susceptible genes in the Chinese population: a meta-analysis of 21 case-control studies.Sleep Breath. 2015 Dec;19(4):1441-8. doi: 10.1007/s11325-015-1176-0. Epub 2015 Apr 28.
54 The use of handheld nasal spirometry to predict the presence of obstructive sleep apnea.Sleep Breath. 2018 Mar;22(1):79-84. doi: 10.1007/s11325-017-1531-4. Epub 2017 Jun 30.
55 Plasma -synuclein levels are increased in patients with obstructive sleep apnea syndrome.Ann Clin Transl Neurol. 2019 Mar 12;6(4):788-794. doi: 10.1002/acn3.756. eCollection 2019 Apr.
56 Lack of associations between thyroid function and obstructive sleep apnea severity in adults with prediabetes and diabetes mellitus.Sleep Breath. 2019 Sep;23(3):963-967. doi: 10.1007/s11325-018-1756-x. Epub 2018 Nov 19.
57 Obstructive sleep apnea may induce orexinergic system and cerebral -amyloid metabolism dysregulation: is it a further proof for Alzheimer's disease risk?.Sleep Med. 2019 Apr;56:171-176. doi: 10.1016/j.sleep.2019.01.003. Epub 2019 Jan 11.
58 Polysomnographic determinants of requirement for advanced positive pressure therapeutic options for obstructive sleep apnea.Sleep Breath. 2018 May;22(2):401-409. doi: 10.1007/s11325-017-1556-8. Epub 2017 Aug 18.
59 Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea.Chest. 2010 Jul;138(1):91-9. doi: 10.1378/chest.09-2832. Epub 2010 Mar 18.
60 Obstructive sleep apnea is independently associated with subclinical coronary atherosclerosis among middle-aged women.Sleep Breath. 2017 Mar;21(1):77-83. doi: 10.1007/s11325-016-1374-4. Epub 2016 Jul 6.
61 SLC35A2-CDG: Functional characterization, expanded molecular, clinical, and biochemical phenotypes of 30 unreported Individuals.Hum Mutat. 2019 Jul;40(7):908-925. doi: 10.1002/humu.23731. Epub 2019 Apr 24.
62 Imbalance of osteoprotegerin/receptor activator of nuclear factor-B ligand and oxidative stress in patients with obstructive sleep apnea-hypopnea syndrome.Chin Med J (Engl). 2019 Jan 5;132(1):25-29. doi: 10.1097/CM9.0000000000000046.
63 Association of Obstructive Sleep Apnea With Cardiovascular Outcomes in Patients With Acute Coronary Syndrome.J Am Heart Assoc. 2019 Jan 22;8(2):e010826. doi: 10.1161/JAHA.118.010826.
64 Association between obstructive sleep apnea and non-alcoholic fatty liver disease: a systematic review and meta-analysis.Sleep Breath. 2018 Sep;22(3):841-851. doi: 10.1007/s11325-018-1625-7. Epub 2018 Jan 15.
65 Proteomic profiling of osteosarcoma cells identifies ALDOA and SULT1A3 as negative survival markers of human osteosarcoma.Mol Carcinog. 2014 Feb;53(2):138-44. doi: 10.1002/mc.21957. Epub 2012 Sep 4.
66 Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea.Biomed Res Int. 2019 Mar 13;2019:5193597. doi: 10.1155/2019/5193597. eCollection 2019.
67 Intermittent Hypoxia Induced Formation of "Endothelial Cell-Colony Forming Units (EC-CFUs)" Is Affected by ROS and Oxidative Stress.Front Neurol. 2018 Jun 14;9:447. doi: 10.3389/fneur.2018.00447. eCollection 2018.
68 8-isoprostanes and resistin as markers of vascular damage in non-hypersomnolent obstructive sleep apnoea patients.Clin Physiol Funct Imaging. 2017 Nov;37(6):695-702. doi: 10.1111/cpf.12361. Epub 2016 Jun 3.
69 Severe depletion of peripheral blood dendritic cell subsets in obstructive sleep apnea patients: A new link with cancer?.Cytokine. 2020 Jan;125:154831. doi: 10.1016/j.cyto.2019.154831. Epub 2019 Aug 29.
70 Patient characteristics as predictors of recurrence of atrial fibrillation following cryoballoon ablation.Pacing Clin Electrophysiol. 2019 Jun;42(6):694-704. doi: 10.1111/pace.13669. Epub 2019 Apr 9.
71 The Association of Salivary Biomarkers With the Severity of Obstructive Sleep Apnea and Concomitant Hypertension.Am J Med Sci. 2019 Jun;357(6):468-473. doi: 10.1016/j.amjms.2019.03.004. Epub 2019 Mar 22.
72 Increased Level of Angiopoietin Like Proteins 4 and 8 in People With Sleep Apnea.Front Endocrinol (Lausanne). 2018 Nov 13;9:651. doi: 10.3389/fendo.2018.00651. eCollection 2018.
73 Serum high-density lipoprotein correlates with serum apolipoprotein M and A5 in obstructive sleep apnea hypopnea syndrome.Sleep Breath. 2017 Mar;21(1):37-44. doi: 10.1007/s11325-016-1357-5. Epub 2016 May 21.
74 Oxidative Stress Markers and Severity of Obstructive Sleep Apnea.Adv Exp Med Biol. 2019;1222:27-35. doi: 10.1007/5584_2019_433.
75 Elevated plasma soluble (pro)renin receptor levels are associated with left ventricular remodeling and renal function in chronic heart failure patients with reduced ejection fraction.Peptides. 2019 Jan;111:152-157. doi: 10.1016/j.peptides.2018.04.010. Epub 2018 Apr 13.
76 Bone Age and Serum Osteocalcin Levels in Children With Obstructive Sleep Apnea Hypopnea Syndrome Before and After Adenotonsillectomy.Am J Ther. 2017 Mar/Apr;24(2):e189-e195. doi: 10.1097/MJT.0000000000000303.
77 miRNA-Mediated Suppression of a Cardioprotective Cardiokine as a Novel Mechanism Exacerbating Post-MI Remodeling by Sleep Breathing Disorders.Circ Res. 2020 Jan 17;126(2):212-228. doi: 10.1161/CIRCRESAHA.119.315067. Epub 2019 Nov 7.
78 Correlation between Calpain-10 single-nucleotide polymorphisms and obstructive sleep apnea/hypopnoea syndrome with ischemic stroke in a Chinese population: A population-based study.Medicine (Baltimore). 2017 Apr;96(16):e6570. doi: 10.1097/MD.0000000000006570.
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80 MRI evaluation of cerebrovascular reactivity in obstructive sleep apnea.J Cereb Blood Flow Metab. 2020 Jun;40(6):1328-1337. doi: 10.1177/0271678X19862182. Epub 2019 Jul 15.
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82 Catestatin serum levels are increased in male patients with obstructive sleep apnea.Sleep Breath. 2019 Jun;23(2):473-481. doi: 10.1007/s11325-018-1703-x. Epub 2018 Aug 7.
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84 Urinary EPCR and dermcidin as potential novel biomarkers for severe adult OSA patients.Sleep Med. 2019 Dec;64:92-100. doi: 10.1016/j.sleep.2019.07.002. Epub 2019 Jul 8.
85 Osteocytes serve as a progenitor cell of osteosarcoma.J Cell Biochem. 2014 Aug;115(8):1420-9. doi: 10.1002/jcb.24793.
86 Associations Between Obstructive Sleep Apnea and Measures of Arterial Stiffness.J Clin Sleep Med. 2019 Feb 15;15(2):201-206. doi: 10.5664/jcsm.7616.
87 Prolyl 4-Hydroxylase Domain Protein 3-Inhibited Smooth-Muscle-Cell Dedifferentiation Improves Cardiac Perivascular Fibrosis Induced by Obstructive Sleep Apnea.Biomed Res Int. 2019 Jun 27;2019:9174218. doi: 10.1155/2019/9174218. eCollection 2019.
88 Adropin and Inflammation Biomarker Levels in Male Patients With Obstructive Sleep Apnea: A Link With Glucose Metabolism and Sleep Parameters.J Clin Sleep Med. 2018 Jul 15;14(7):1109-1118. doi: 10.5664/jcsm.7204.
89 ESM-1 promotes adhesion between monocytes and endothelial cells under intermittent hypoxia.J Cell Physiol. 2019 Feb;234(2):1512-1521. doi: 10.1002/jcp.27016. Epub 2018 Aug 24.
90 Diet associated with exercise improves baroreflex control of sympathetic nerve activity in metabolic syndrome and sleep apnea patients.Sleep Breath. 2019 Mar;23(1):143-151. doi: 10.1007/s11325-018-1675-x. Epub 2018 Jun 11.
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92 Association between Single Nucleotide Polymorphisms in Gamma-Aminobutyric Acid B Receptor, Insulin Receptor Substrate-1, and Hypocretin Neuropeptide Precursor Genes and Susceptibility to Obstructive Sleep Apnea Hypopnea Syndrome in a Chinese Han Population.Med Princ Pract. 2016;25(6):517-524. doi: 10.1159/000448997. Epub 2016 Aug 10.
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96 Using a modified version of the "STOP-BANG" questionnaire and nocturnal oxygen desaturation to predict obstructive sleep apnea after stroke or TIA.Sleep Med. 2019 Apr;56:177-183. doi: 10.1016/j.sleep.2018.12.021. Epub 2019 Jan 7.
97 Auto positive airway pressure therapy reduces pulmonary pressures in adults admitted for acute heart failure with pulmonary hypertension and obstructive sleep apnea. The ASAP-HF Pilot Trial.Sleep. 2019 Jul 8;42(7):zsz100. doi: 10.1093/sleep/zsz100.
98 Obesity and Co-morbid Conditions Are Associated with Specific Neuropsychiatric Symptoms in Mild Cognitive Impairment.Front Aging Neurosci. 2017 May 29;9:164. doi: 10.3389/fnagi.2017.00164. eCollection 2017.
99 Role of microRNA-130a in the pathogeneses of obstructive sleep apnea hypopnea syndrome-associated pulmonary hypertension by targeting the GAX gene.Medicine (Baltimore). 2017 May;96(20):e6746. doi: 10.1097/MD.0000000000006746.
100 Bone metabolism parameters and inactive matrix Gla protein in patients with obstructive sleep apnea?"Vilovic M. Ticinovic Kurir T
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102 Heat-moulded versus custom-made mandibular advancement devices for obstructive sleep apnoea: a randomised non-inferiority trial.Thorax. 2019 Jul;74(7):667-674. doi: 10.1136/thoraxjnl-2018-212726. Epub 2019 May 3.
103 Circulating autoantibodies against neuroblastoma suppressor of tumorigenicity 1 (NBL1): A potential biomarker for coronary artery disease in patients with obstructive sleep apnea.PLoS One. 2018 Mar 29;13(3):e0195015. doi: 10.1371/journal.pone.0195015. eCollection 2018.
104 Non-synonymous polymorphism in the neuropeptide S precursor gene and sleep apnea.Sleep Breath. 2011 Sep;15(3):403-8. doi: 10.1007/s11325-010-0348-1. Epub 2010 Apr 21.
105 Contributions of the Melanopsin-Expressing Ganglion Cells, Cones, and Rods to the Pupillary Light Response in Obstructive Sleep Apnea.Invest Ophthalmol Vis Sci. 2019 Jul 1;60(8):3002-3012. doi: 10.1167/iovs.19-26944.
106 Evidence that 5-HT stimulates intracellular Ca(2+) signalling and activates pannexin-1 currents in type II cells of the rat carotid body.J Physiol. 2017 Jul 1;595(13):4261-4277. doi: 10.1113/JP273473. Epub 2017 Apr 25.
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108 Changes in inflammatory mediators as a result of intermittent hypoxia in obstructive sleep apnea syndrome.Clin Respir J. 2018 Apr;12(4):1615-1622. doi: 10.1111/crj.12718. Epub 2017 Nov 23.
109 High frequency of Bob1(lo) T follicular helper cells in florid reactive follicular hyperplasia.Immunol Lett. 2017 Nov;191:23-30. doi: 10.1016/j.imlet.2017.07.012. Epub 2017 Jul 26.
110 Long-term follow-up of the German post-market study for upper airway stimulation for obstructive sleep apnea.Sleep Breath. 2020 Sep;24(3):979-984. doi: 10.1007/s11325-019-01933-0. Epub 2019 Sep 4.
111 Is Maxillomandibular Advancement Associated With Comorbidity Reduction in Patients With Obstructive Sleep Apnea?.J Oral Maxillofac Surg. 2019 May;77(5):1044-1049. doi: 10.1016/j.joms.2018.12.006. Epub 2018 Dec 17.
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113 Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men.Am J Respir Cell Mol Biol. 2018 Mar;58(3):391-401. doi: 10.1165/rcmb.2017-0237OC.
114 REM sleep and sleep apnea are associated with language function in Down syndrome children: An analysis of a community sample.J Formos Med Assoc. 2020 Jan;119(1 Pt 3):516-523. doi: 10.1016/j.jfma.2019.07.015. Epub 2019 Aug 1.
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117 Pulmonary surfactant-associated proteins and inflammatory factors in obstructive sleep apnea.Sleep Breath. 2018 Mar;22(1):99-107. doi: 10.1007/s11325-017-1536-z. Epub 2017 Jul 13.
118 The CC genotype of the delta-sarcoglycan gene polymorphism rs13170573 is associated with obstructive sleep apnea in the Chinese population.PLoS One. 2014 Dec 4;9(12):e114160. doi: 10.1371/journal.pone.0114160. eCollection 2014.
119 Effect of Supplemental Oxygen on Blood Pressure in Obstructive Sleep Apnea (SOX). A Randomized Continuous Positive Airway Pressure Withdrawal Trial.Am J Respir Crit Care Med. 2019 Jan 15;199(2):211-219. doi: 10.1164/rccm.201802-0240OC.
120 Responsiveness of Patient-Reported Outcomes to Treatment Among Patients With Type 2 Diabetes Mellitus and OSA.Chest. 2020 Mar;157(3):665-672. doi: 10.1016/j.chest.2019.11.011. Epub 2019 Nov 27.