Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM8EVK5)

Drug Name
Wortmannin Drug Info
Synonyms
wortmannin; 19545-26-7; Wartmannin; KY 12420; Antibiotic SL-2052; SL-2052; UNII-XVA4O219QW; NSC221019; XVA4O219QW; MLS002703028; CHEMBL428496; CHEBI:52289; Wortmannin, 98%; Pi 3-Kinase Inhibitor; NSC 627609; BRN 0067676; (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate
Indication
Disease Entry ICD 11 Status REF
Haematological malignancy 2B33.Y Terminated [1]
Cross-matching ID
PubChem CID
312145
ChEBI ID
CHEBI:52289
CAS Number
CAS 19545-26-7
TTD Drug ID
DM8EVK5

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting PI3-kinase delta (PIK3CD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [12]
Idelalisib DM602WT Chronic lymphocytic leukaemia 2A82.0 Approved [13]
Umbralisib DMYRBO1 Follicular lymphoma 2A80 Approved [14]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [15]
Leniolisib DMWAD93 Stomach cancer 2B72 Approved [16]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [17]
INCB50465 DMZJP2T Diffuse large B-cell lymphoma 2A81 Phase 2 [18]
ME-401 DMK0UOY Follicular lymphoma 2A80 Phase 2 [18]
RP6530 DMYILGK Chronic lymphocytic leukaemia 2A82.0 Phase 2 [18]
Parsaclisib DMYBIFS Follicular lymphoma 2A80 Phase 2 [19]
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Drug(s) Targeting PI3-kinase gamma (PIK3CG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BAY 80-6946 DMLOS5R Follicular lymphoma 2A80 Approved [20]
IPI-145 DMWA24P Follicular lymphoma 2A80 Approved [15]
Buparlisib DM1WEHC Breast cancer 2C60-2C65 Phase 3 [17]
Enzastaurin DM5H0R9 Diffuse large B-cell lymphoma 2A81 Phase 3 [18]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [21]
GDC-0032 DMT4QHD Breast cancer 2C60-2C65 Phase 3 [18]
PQR309 DMMCYZ8 Squamous head and neck cell carcinom 2D60.0 Phase 2 [22]
SAR245409 DMQM7IL Solid tumour/cancer 2A00-2F9Z Phase 2 [23]
XL147 DMML7BE Solid tumour/cancer 2A00-2F9Z Phase 2 [23]
SF1126 DML10K3 Head and neck cancer 2D42 Phase 2 [24]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [25]
Selenium DM25CGV N. A. N. A. Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Quercetin DM3NC4M Obesity 5B81 Approved [28]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [29]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [32]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
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Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [6]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [35]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [35]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [36]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [6]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [35]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [37]
Gefitinib DM15F0X Colon adenocarcinoma Approved [6]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [38]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [6]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [31]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [42]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Etretinate DM2CZFA Keratosis ED56 Approved [44]
Prednisone DM2HG4X Acute asthma CA23 Approved [45]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [46]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
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Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Methotrexate DM2TEOL Anterior urethra cancer Approved [49]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [55]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [56]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [57]
Gefitinib DM15F0X Colon adenocarcinoma Approved [41]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [58]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Etretinate DM2CZFA Keratosis ED56 Approved [44]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [61]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [62]
Quercetin DM3NC4M Obesity 5B81 Approved [63]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [64]
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Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [69]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [71]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
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Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [75]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [72]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Capsaicin DMGMF6V Back pain ME84.Z Approved [80]
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Drug(s) Affected By Insulin-like growth factor II (IGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
Folic Acid DMEMBJC Colorectal carcinoma Approved [89]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [90]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [91]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [92]
Fructose DM43AN2 Vomiting MD90 Approved [93]
Ketoprofen DMRKXPT Bursitis Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [94]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [102]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [104]
Paclitaxel DMLB81S Breast carcinoma Approved [105]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [106]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [108]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [109]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [110]
Selenium DM25CGV N. A. N. A. Approved [111]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [113]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [116]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [117]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [118]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [119]
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Drug(s) Affected By Intestinal-type alkaline phosphatase (ALPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [121]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [121]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [122]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [123]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [124]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [125]
cycloheximide DMGDA3C Discovery agent N.A. Investigative [126]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [127]
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Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [128]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [130]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Selenium DM25CGV N. A. N. A. Approved [132]
Etretinate DM2CZFA Keratosis ED56 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [135]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [137]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [138]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [139]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [140]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [143]
Panobinostat DM58WKG Chronic graft versus host disease Approved [84]
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Drug(s) Affected By Secretogranin-2 (SCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [84]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [145]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [146]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [147]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [148]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [149]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [150]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [151]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [152]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [153]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Selenium DM25CGV N. A. N. A. Approved [111]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [154]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [156]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [157]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [158]
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Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [159]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [160]
Gefitinib DM15F0X Colon adenocarcinoma Approved [161]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [163]
Quercetin DM3NC4M Obesity 5B81 Approved [164]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [167]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [168]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [136]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [59]
Methotrexate DM2TEOL Anterior urethra cancer Approved [169]
Epinephrine DM3KJBC Acute asthma CA23 Approved [170]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [172]
Fructose DM43AN2 Vomiting MD90 Approved [173]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [174]
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Drug(s) Affected By Metallothionein-3 (MT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [177]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [178]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [179]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [180]
Arsenic DMTL2Y1 N. A. N. A. Approved [181]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [182]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [184]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [185]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [186]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [187]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [188]
Gefitinib DM15F0X Colon adenocarcinoma Approved [189]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [190]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [191]
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Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Quercetin DM3NC4M Obesity 5B81 Approved [193]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [194]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [68]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [195]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [196]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [77]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [198]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [199]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [184]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [200]
Paclitaxel DMLB81S Breast carcinoma Approved [201]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [202]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [93]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [203]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [186]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [204]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [205]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [93]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [207]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [209]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [210]
Fructose DM43AN2 Vomiting MD90 Approved [211]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [213]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [214]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [107]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [215]
Gefitinib DM15F0X Colon adenocarcinoma Approved [216]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [162]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [217]
Selenium DM25CGV N. A. N. A. Approved [132]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [218]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [219]
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Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [220]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [221]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [222]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [223]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [224]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [225]
Testosterone DM7HUNW Hot flushes GA30 Approved [226]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [227]
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Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Fluoxetine DM3PD2C Bipolar depression Approved [228]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [229]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [230]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [231]
Leflunomide DMR8ONJ Arthritis FA20 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [229]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [229]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [36]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [203]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [233]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [235]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [236]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [237]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [238]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [239]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
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Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [196]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [241]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [149]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [93]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [166]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [242]
Gefitinib DM15F0X Colon adenocarcinoma Approved [243]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [244]
Selenium DM25CGV N. A. N. A. Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [245]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [247]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [248]
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Drug(s) Affected By Selenoprotein P (SELENOP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [233]
Selenium DM25CGV N. A. N. A. Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Panobinostat DM58WKG Chronic graft versus host disease Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [235]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [249]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [250]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [251]
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Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [252]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [253]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [253]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [255]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [234]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [253]
Ethacrynic acid DM60QMR Edema MG29 Approved [253]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [253]
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Drug(s) Affected By Myosin regulatory light chain 2, atrial isoform (MYL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [256]
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [257]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [258]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [149]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [259]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [258]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [260]
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Drug(s) Affected By Elongation factor 1-alpha 2 (EEF1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [261]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [262]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [79]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [263]
Clozapine DMFC71L Schizophrenia 6A20 Approved [264]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [145]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [265]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [266]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [95]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [136]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [267]
Methotrexate DM2TEOL Anterior urethra cancer Approved [156]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [268]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [269]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [270]
Ethacrynic acid DM60QMR Edema MG29 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [272]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [273]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [274]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [275]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [276]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [277]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [278]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [279]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [280]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [281]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [282]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [283]
Prednisone DM2HG4X Acute asthma CA23 Approved [284]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [284]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [285]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [286]
Epinephrine DM3KJBC Acute asthma CA23 Approved [287]
Quercetin DM3NC4M Obesity 5B81 Approved [171]
Fluoxetine DM3PD2C Bipolar depression Approved [288]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [165]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death protein 4 (PDCD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [289]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [290]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [289]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [235]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [291]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [249]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [289]
Testosterone DM7HUNW Hot flushes GA30 Approved [197]
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Drug(s) Affected By Krueppel-like factor 6 (KLF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [292]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [293]
Selenium DM25CGV N. A. N. A. Approved [132]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [294]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [52]
Panobinostat DM58WKG Chronic graft versus host disease Approved [84]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [74]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [129]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [43]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [47]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [60]
Quercetin DM3NC4M Obesity 5B81 Approved [295]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [296]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [297]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [298]
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Drug(s) Affected By Forkhead box protein P1 (FOXP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [53]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [299]
Leflunomide DMR8ONJ Arthritis FA20 Approved [73]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [300]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [301]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [178]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [241]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [147]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PI3-kinase delta (PIK3CD) TTGBPJE PK3CD_HUMAN Inhibitor [2]
PI3-kinase gamma (PIK3CG) TTHBTOP PK3CG_HUMAN Inhibitor [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [4]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Gene/Protein Processing [5]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [5]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [6]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [7]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [8]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Post-Translational Modifications [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [10]
Elongation factor 1-alpha 2 (EEF1A2) OT9Z23K5 EF1A2_HUMAN Gene/Protein Processing [11]
Forkhead box protein O3 (FOXO3) OTHXQG4P FOXO3_HUMAN Post-Translational Modifications [7]

References

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11 eEF1A2 siRNA Suppresses MPP(+)-Induced Activation of Akt and mTOR and Potentiates Caspase-3 Activation in a Parkinson's Disease Model. ScientificWorldJournal. 2023 Apr 3;2023:1335201. doi: 10.1155/2023/1335201. eCollection 2023.
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30 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
31 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
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33 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
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38 A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
39 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
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41 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
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49 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
50 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
51 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
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58 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
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