Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMG3F94)

• Drug Name: Mestranol Drug Info
• Synonyms: Devocin; Menophase; Mestranolo; Mestranolum; Norquen; Ovastol; Component of Norinyl; Component of Norquen; Component of Ovulen; Ethynylestradiol methyl ether; Mestranol [Steroidal oestrogens]; Mestranolo [DCIT]; EE3ME; Ethinyl Estradiol 3 Methyl Ether; SC 4725; Component of Ortho-Novum; Delta-MVE; EE(sub3)ME; EthinylEstradiol 3-Methyl Ether; Ethinylestradiol 3-methyl ether; Ethinyloestradiol 3-methyl ether; Ethynylestradiol 3-methyl ether; Ethynyloestradiol 3-methyl ether; Inostral (steroid); Mestranolum [INN-Latin]; Mestranol (JP15/USP/INN); Mestranol [USAN:INN:BAN:JAN]; Alpha.-19-Norpregna-1,3,5(10)-trien-20-yn-17-ol, 3-meth; (17beta)-17-ethynyl-3-(methyloxy)estra-1,3,5(10)-trien-17-ol; 17-Ethynyl-3-methoxy-1,3,5(10)-oestratien-17-beta-ol; 17-Ethynyl-3-methoxyestra-1,3,5(10)-trien-17-ol; 17-Ethynylestradiol 3-methyl ether; 17-Ethynyloestradiol 3-methyl ether; 17-alpha-Ethinyl estradiol 3-methyl ether; 17-alpha-Ethinyl oestradiol 3-methyl ether; 17-alpha-Ethynyl-3-methoxy-1,3,5(10)-estratrien-17-beta-ol; 17-alpha-Ethynyloestradiol methyl ether; 17-ethynyl-3-methoxyestra-1(10),2,4-trien-17beta-ol; 17-ethynyl-3-methoxyoestra-1(10),2,4-trien-17beta-ol; 17alpha-Ethinyl estradiol 3-methyl ether; 17alpha-Ethinyl oestradiol 3-methyl ether; 17alpha-Ethinylestradiol 3-methyl ether; 17alpha-Ethynylestradiol 3-methyl ether; 17alpha-Ethynylestradiol methyl ether; 17alpha-Ethynyloestradiol 3-methyl ether; 17beta-Estradiol, 17-ethynyl-, 3-(methyl ether); 3-Methoxy-17-alpha-19-norpregna-1,3,5(10)-trien-20-yn-17-ol; 3-Methoxy-17-alpha-ethinylestradiol; 3-Methoxy-17-alpha-ethinyloestradiol; 3-Methoxy-17-alpha-ethynyl-1,3,5(10)-estratrien-17-beta-ol; 3-Methoxy-17-alpha-ethynyl-1,3,5(10)-oestratrien-17-beta-ol; 3-Methoxy-17-alpha-ethynylestradiol; 3-Methoxy-17-alpha-ethynyloestradiol; 3-Methoxy-17-ethynyloestradiol-17-beta; 3-Methoxy-17alpha-ethinylestradiol; 3-Methoxy-17alpha-ethinyloestradiol; 3-Methoxy-17alpha-ethynyl-1,3,5(10)-estratrien-17beta-ol; 3-Methoxy-17alpha-ethynyl-1,3,5(10)-oestratrien-17beta-ol; 3-Methoxy-17alpha-ethynylestradiol; 3-Methoxy-17alpha-ethynyloestradiol; 3-Methoxy-19-nor-17-alpha-pregna-1,3,5(10)-trien-20-yn-17-ol; 3-Methoxy-19-nor-17alpha-pregna-1,3,5(10)-trien-20-yn-17-ol; 3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17beta-ol; 3-Methoxyethynylestradiol; 3-Methoxyethynyloestradiol; 3-Methylethynylestradiol; 3-Methylethynyloestradiol; 3-O-Methylethynylestradiol

Indication

Disease Entry	ICD 11	Status	REF
Contraception	QA21	Approved	[1]
Menorrhagia	GA20.50	Approved	[2]
Endometriosis	GA10	Investigative	[2]

• Therapeutic Class: Estrogens
• Cross-matching ID:
  PubChem CID: 6291
  ChEBI ID: CHEBI:6784
  CAS Number: CAS 72-33-3
  TTD Drug ID: DMG3F94
  INTEDE Drug ID: DR1034

Molecule-Related Drug Atlas

Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[9]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[10]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[10]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[11]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[11]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[11]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[12]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[13]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[14]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[15]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[17]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[22]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[23]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[17]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[5]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[28]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[29]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[25]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[30]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[31]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[36]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[41]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[45]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]

Drug(s) Affected By Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[60]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Carbonic anhydrase 12 (CA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[71]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[73]

Drug(s) Affected By monooxygenase MICAL2 (MICAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Serine protease 23 (PRSS23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[80]

Drug(s) Affected By Supervillin (SVIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[60]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[60]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[94]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[97]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[98]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[101]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[100]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Bortezomib	DMNO38U	Leukemia		Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[110]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[111]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[112]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[116]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[117]

Drug(s) Affected By Delta-aminolevulinic acid dehydratase (ALAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[121]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[127]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[130]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[135]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[138]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[142]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[143]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[147]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[153]

Drug(s) Affected By Ephrin type-A receptor 4 (EPHA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Single-stranded DNA-binding protein 2 (SSBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[7]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[160]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[150]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[161]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[163]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[165]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[150]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]

Drug(s) Affected By Forkhead box protein C1 (FOXC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]

Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[45]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[60]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]

Drug(s) Affected By Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[150]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[179]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[179]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[116]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[63]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[185]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[186]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]

Drug(s) Affected By Inactive rhomboid protein 1 (RHBDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[187]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[188]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[189]

Drug(s) Affected By Calmin (CLMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[187]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[188]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[116]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[186]

Drug(s) Affected By Noelin (OLFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[190]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[191]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[195]

Drug(s) Affected By Pleckstrin homology domain-containing family F member 2 (PLEKHF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[7]

Drug(s) Affected By Spermine oxidase (SMOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Nicotinamide riboside kinase 1 (NMRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[121]

Drug(s) Affected By Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[200]

Drug(s) Affected By RNA 3'-terminal phosphate cyclase-like protein (RCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[55]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[7]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[202]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[205]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[206]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[208]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[204]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[209]

Drug(s) Affected By Coagulation factor VII (F7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[52]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[64]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[210]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[211]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[212]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[213]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[214]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[215]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[68]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[217]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[218]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[215]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[221]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[223]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[226]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[227]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Agonist	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[7]
Calmin (CLMN)	OT7U5J3T	CLMN_HUMAN	Gene/Protein Processing	[7]
Carbonic anhydrase 12 (CA12)	OT6WNFU8	CAH12_HUMAN	Gene/Protein Processing	[7]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Gene/Protein Processing	[7]
Coagulation factor VII (F7)	OTGNJ97M	FA7_HUMAN	Gene/Protein Processing	[8]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Gene/Protein Processing	[7]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Gene/Protein Processing	[7]
DNA endonuclease RBBP8 (RBBP8)	OTRHJ3GI	CTIP_HUMAN	Gene/Protein Processing	[7]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Gene/Protein Processing	[7]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)	OTMDVWPS	DYRK2_HUMAN	Gene/Protein Processing	[7]

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