Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVW7N3)

• Drug Name: taurine Drug Info
• Synonyms: taurine; 2-aminoethanesulfonic acid; 107-35-7; tauphon; L-Taurine; Ethanesulfonic acid, 2-amino-; 2-Aminoethylsulfonic acid; O-Due; 2-Sulfoethylamine; taufon; Aminoethanesulfonic acid; aminoethylsulfonic acid; beta-Aminoethylsulfonic acid; 2-aminoethane-1-sulfonic acid; Taurinum [Latin]; Taurina [Spanish]; Taurine [INN]; FEMA No. 3813; CCRIS 4721; UNII-1EQV5MLY3D; NCI-C60606; AI3-18307; NSC32428; EINECS 203-483-8; NSC 32428; 1EQV5MLY3D; .beta.-Aminoethylsulfonic acid; 1-Aminoethane-2-sulfonic acid; CHEBI:15891

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1123
  ChEBI ID: CHEBI:15891
  CAS Number: CAS 107-35-7
  TTD Drug ID: DMVW7N3
  VARIDT Drug ID: DR00167
  INTEDE Drug ID: DR1534

Molecule-Related Drug Atlas

Drug(s) Targeting Glycine receptor (GlyR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
THIOCOLCHICOSIDE	DMEPWYA	Muscle spasm	MB47.3	Approved	[7]
ZD-9379	DM3KYO4	Cerebrovascular ischaemia	8B1Z	Phase 1	[8]
UK-240455	DMSCXB7	Nerve injury	ND56.4	Phase 1	[9]
MDL-27531	DMC60S8	Epilepsy	8A60-8A68	Phase 1	[10]
Gavestinel	DM8IL1U	Nerve injury	ND56.4	Discontinued in Phase 2	[11]
GV-196771	DMFN21T	Migraine	8A80	Discontinued in Phase 2	[12]
GW 468816	DMQ92WF	Tobacco dependence	6C4A.2	Discontinued in Phase 2	[13]
M-241247	DMIY51U	Cerebrovascular ischaemia	8B1Z	Terminated	[14]
GINKOLIDE B	DMLIM7B	Sepsis	1G40-1G41	Terminated	[15]
3-demethoxy-3-D-lyxopyranosylaminothiocolchicine	DME8VPC	Discovery agent	N.A.	Investigative	[7]

Drug(s) Transported By Sodium- and chloride-dependent taurine transporter (SLC6A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-Alanine	DMC64EI	Discovery agent	N.A.	Investigative	[3]

Drug(s) Metabolized By Bile acid-CoA thioesterase (BAAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[5]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[16]
ZX-AP000068	DM4Y0NI	N. A.	N. A.	Investigative	[5]
NSC-39851	DMMXZBK	N. A.	N. A.	Investigative	[5]

Drug(s) Affected By Krev interaction trapped protein 1 (KRIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Bortezomib	DMNO38U	Leukemia		Approved	[22]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[23]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[24]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[32]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[33]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[38]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]

Drug(s) Affected By Glutathione S-transferase LANCL1 (LANCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[49]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[50]

Drug(s) Affected By snRNA-activating protein complex subunit 5 (SNAPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[49]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[52]

Drug(s) Affected By N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]

Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[54]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[58]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Indomethacin	DMSC4A7	Bursitis		Approved	[60]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]

Drug(s) Affected By Serine/threonine-protein kinase PAK 4 (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[64]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[49]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[67]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[70]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[61]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[73]

Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[76]

Drug(s) Affected By DNA polymerase beta (POLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[78]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[79]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[80]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[81]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[42]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[90]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[94]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By N-chimaerin (CHN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[41]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[100]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[107]

Drug(s) Affected By Ras-related protein Rab-5A (RAB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Bortezomib	DMNO38U	Leukemia		Approved	[22]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[109]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[99]

Drug(s) Affected By Substance-P receptor (TACR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[41]
SU5402	DM9JON3	Multiple myeloma	2A83	Investigative	[113]
Manganese	DMKT129	N. A.	N. A.	Investigative	[114]

Drug(s) Affected By DNA polymerase delta catalytic subunit (POLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]

Drug(s) Affected By Adenosine receptor A2a (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[120]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[121]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[119]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[119]

Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[123]

Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[124]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[127]
Terbutaline	DMD4381	Asthma	CA23	Approved	[128]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]

Drug(s) Affected By Adenylyl cyclase-associated protein 2 (CAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[131]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[80]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[140]

Drug(s) Affected By Tyrosine-protein kinase ABL2 (ABL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[109]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[143]

Drug(s) Affected By C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[80]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[146]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[147]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[148]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[150]

Drug(s) Affected By Presenilin-2 (PSEN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[152]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[132]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[161]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Signal recognition particle subunit SRP54 (SRP54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[163]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[52]

Drug(s) Affected By COP9 signalosome complex subunit 2 (COPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[109]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[100]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[164]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[165]

Drug(s) Affected By Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[167]

Drug(s) Affected By Angiopoietin-1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[168]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[168]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[170]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[172]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[98]

Drug(s) Affected By Diacylglycerol kinase zeta (DGKZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[154]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Bone morphogenetic protein receptor type-2 (BMPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[174]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[178]

Drug(s) Affected By Metabotropic glutamate receptor 7 (GRM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[41]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[182]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[184]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[185]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (PPP2R5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[186]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[192]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[192]

Drug(s) Affected By Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[179]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[193]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Cell cycle checkpoint control protein RAD9A (RAD9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[196]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[197]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[198]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[199]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[200]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[201]

Drug(s) Affected By Olfactory receptor 51E2 (OR51E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 6A (MS4A6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[202]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[179]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[204]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[205]

Drug(s) Affected By DNA-directed DNA/RNA polymerase mu (POLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[206]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[206]
Bortezomib	DMNO38U	Leukemia		Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[207]

Drug(s) Affected By Arf-GAP with dual PH domain-containing protein 2 (ADAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[208]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[210]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[213]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[117]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Bortezomib	DMNO38U	Leukemia		Approved	[22]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[216]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[217]

Drug(s) Affected By Rap guanine nucleotide exchange factor 2 (RAPGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[99]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[67]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[218]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[224]
Fructose	DM43AN2	Vomiting	MD90	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[226]

Drug(s) Affected By Protein DEK (DEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[31]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycine receptor (GlyR)	TTZ8EM9	GLRA1_HUMAN; GLRA2_HUMAN; GLRA3_HUMAN; GLRA4_HUMAN; GLRB_HUMAN	Agonist	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium- and chloride-dependent taurine transporter (SLC6A6)	DTHWCVA	SC6A6_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Transglutaminase Y (TGM6)	DEUWCVD	TGM3L_HUMAN	Substrate	[4]
Bile acid-CoA thioesterase (BAAT)	DERA3OF	BAAT_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Adenosine receptor A2a (ADORA2A)	OTVRBZ0I	AA2AR_HUMAN	Gene/Protein Processing	[6]
Adenylyl cyclase-associated protein 2 (CAP2)	OTC1WFNO	CAP2_HUMAN	Gene/Protein Processing	[6]
Alpha-1B adrenergic receptor (ADRA1B)	OTSAYAFD	ADA1B_HUMAN	Gene/Protein Processing	[6]
Angiopoietin-1 receptor (TEK)	OT78YN57	TIE2_HUMAN	Gene/Protein Processing	[6]
Arf-GAP with dual PH domain-containing protein 2 (ADAP2)	OTGQ8UH7	ADAP2_HUMAN	Gene/Protein Processing	[6]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[6]
Bone morphogenetic protein receptor type-2 (BMPR2)	OTM9W547	BMPR2_HUMAN	Gene/Protein Processing	[6]
C-X-C chemokine receptor type 3 (CXCR3)	OTIGS220	CXCR3_HUMAN	Gene/Protein Processing	[6]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)	OTZEXEFH	KAP3_HUMAN	Gene/Protein Processing	[6]
Cell cycle checkpoint control protein RAD9A (RAD9A)	OTJ3AJQU	RAD9A_HUMAN	Gene/Protein Processing	[6]

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