General Information of Disease (ID: DISTC6NO)

Disease Name Malignant soft tissue neoplasm
Synonyms
malignant soft tissue neoplasm; malignant soft tissue tumour; malignant tumor of the soft tissue; malignant neoplasm of soft tissue; malignant neoplasm of the soft tissue; malignant soft tissue tumor; malignant tumor of soft tissue; malignant tumour of the soft tissue; malignant tumour of soft tissue
Definition A malignant neoplasm arising exclusively from the soft tissues.
Disease Hierarchy
DISP2OHE: Soft tissue neoplasm
DISAT1Z9: Advanced cancer
DISTC6NO: Malignant soft tissue neoplasm
Disease Identifiers
MONDO ID
MONDO_0024637
UMLS CUI
C4551686
MedGen ID
1632429
SNOMED CT ID
269469005

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 76 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AMHR2 TTZDCPK Limited Altered Expression [1]
CD6 TTMF6KC Limited Genetic Variation [2]
DICER1 TTTEOPU Limited Biomarker [3]
EGLN1 TT9ISBX Limited Altered Expression [4]
FABP3 TT3TGLR Limited Biomarker [5]
FAP TTGPQ0F Limited Biomarker [6]
FLT3 TTGJCWZ Limited Biomarker [7]
MST1R TTBQ3OC Limited Biomarker [8]
NME1 TTDY8JH Limited Altered Expression [9]
PDGFB TTQA6SX Limited Biomarker [10]
PLOD2 TT8MEUD Limited Biomarker [11]
RICTOR TT143WL Limited Altered Expression [12]
TYRO3 TTIEMFN Limited Altered Expression [13]
XPO1 TTCJUR4 Limited Altered Expression [14]
CSF2RA TT6MP2Z Disputed Altered Expression [15]
CSF2RB TTPYS82 Disputed Biomarker [15]
IL3RA TTENHJ0 Disputed Altered Expression [15]
CLDN4 TTMTS9H moderate Altered Expression [16]
CSPG4 TT7MYXI moderate Biomarker [17]
GLI1 TTJOMH6 moderate Biomarker [18]
ITGAM TTB69FJ moderate Biomarker [19]
MDM4 TT9OUDQ moderate Altered Expression [20]
NACC1 TT4AQ5F moderate Altered Expression [21]
PLIN1 TTIV27N moderate Biomarker [22]
ROR1 TTDEJAU moderate Biomarker [23]
TUSC2 TTJ8O14 moderate Altered Expression [24]
ABHD6 TTSINOV Strong Biomarker [25]
ABL2 TT1A6HL Strong Biomarker [26]
AMOT TTI48OS Strong Posttranslational Modification [27]
ANO1 TTOJI4S Strong Altered Expression [28]
ATRAID TTFLIKM Strong Genetic Variation [29]
BPI TTXCSDR Strong Biomarker [30]
CD248 TTYJWT7 Strong Altered Expression [31]
CD274 TT8ZLTI Strong Biomarker [32]
CD3E TTZAT79 Strong Altered Expression [33]
CDK4 TT0PG8F Strong Genetic Variation [34]
CDKN2C TTBRUGA Strong Genetic Variation [29]
CLIC1 TT8KZG6 Strong Biomarker [35]
CPE TTXPWO6 Strong Altered Expression [36]
CRTC1 TT4GO0F Strong Genetic Variation [37]
CSF1R TT7MRDV Strong Biomarker [38]
CSK TTX6F0Q Strong Altered Expression [39]
CTAG1A TTE5ITK Strong Biomarker [40]
EML4 TT92GY4 Strong Biomarker [41]
FER TTRA9G0 Strong Biomarker [7]
FOXO1 TTLRVIA Strong Biomarker [42]
FPR1 TT5Y4EM Strong Biomarker [43]
FSHR TTZFDBT Strong Biomarker [44]
G3BP1 TTG0R8Z Strong Altered Expression [45]
GABRG2 TT06RH5 Strong Biomarker [46]
GP6 TTTJUVZ Strong Biomarker [47]
GRHL2 TTUGH4C Strong Altered Expression [48]
HRH1 TTTIBOJ Strong Altered Expression [49]
KAT6A TT6O1J0 Strong Biomarker [50]
KCNJ4 TTXF0ZW Strong Biomarker [51]
KIT TTX41N9 Strong Altered Expression [52]
LAG3 TTNVXAW Strong Biomarker [53]
LCK TT860QF Strong Biomarker [54]
LSS TT7O8ZA Strong Biomarker [55]
MAGEA3 TTWSKHD Strong Altered Expression [56]
MAGEC2 TTKGUEB Strong Biomarker [57]
MELK TTBZOTY Strong Biomarker [58]
NAPRT TTVR1FW Strong Biomarker [59]
PDGFRA TT8FYO9 Strong Biomarker [60]
PLK2 TT976FS Strong Biomarker [57]
RBPJ TT72D4Z Strong Biomarker [61]
SIK1 TT1H6LC Strong Genetic Variation [62]
SLC9A3 TTFZVPO Strong Biomarker [63]
SMARCA4 TTVQEZS Strong Genetic Variation [64]
SRC TT6PKBN Strong Biomarker [65]
STMN1 TT7W5OT Strong Biomarker [66]
TLN1 TTQSMFG Strong Genetic Variation [58]
TNFRSF21 TT8UA0T Strong Altered Expression [67]
VIPR1 TTCL30I Strong Altered Expression [68]
YES1 TT0SQ8J Strong Biomarker [69]
ZWINT TTWY768 Strong Biomarker [70]
------------------------------------------------------------------------------------
⏷ Show the Full List of 76 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCB5 DTKVEXO Strong Biomarker [71]
SLC25A16 DTNU9EW Strong Biomarker [72]
SLC27A5 DT0TQS3 Strong Biomarker [73]
------------------------------------------------------------------------------------
This Disease Is Related to 172 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACSL3 OT3MWER1 Limited Biomarker [74]
ACSL4 OTI71MUJ Limited Biomarker [74]
ASPSCR1 OTXTOD10 Limited Biomarker [75]
ATP23 OT303R2T Limited Biomarker [76]
BANF1 OTP7Z38L Limited Altered Expression [77]
DEPDC1B OTMVFOT1 Limited Altered Expression [78]
ERCC5 OTQAKFJM Limited Altered Expression [79]
FLI1 OT0EV3LX Limited Biomarker [80]
LATS1 OTOOCG4R Limited Genetic Variation [81]
LIN28B OTVWP0FN Limited Biomarker [82]
NCOA2 OTMQFPBB Limited Biomarker [83]
NDC80 OTS7D306 Limited Altered Expression [84]
NPAS2 OTMRT2TS Limited Genetic Variation [85]
NUTM2A OTQ4VQXE Limited Genetic Variation [86]
OGA OT7ZBWT1 Limited Genetic Variation [87]
POLM OT0SRIP4 Limited Biomarker [76]
PRUNE1 OTQ3UHWQ Limited Biomarker [9]
RANBP2 OTFG5CVF Limited Genetic Variation [88]
RNASE3 OTVE2XD1 Limited Genetic Variation [89]
RPL17 OTTYMPS6 Limited Biomarker [90]
SART3 OTC1AM7S Limited Genetic Variation [91]
SKI OT4KJ8F6 Limited Biomarker [70]
SMARCA1 OT0Y6PTU Limited Biomarker [77]
SPATA2 OTOA45GL Limited Biomarker [90]
TGFBR3 OTQOOUC4 Limited Biomarker [87]
THY1 OTVONVTB Limited Biomarker [92]
TOPBP1 OT6UPZPD Limited Altered Expression [93]
TSPAN1 OTZQPIYK Limited Biomarker [94]
ATF1 OT251CI0 Disputed Altered Expression [95]
AMER1 OT8EFJPM moderate Biomarker [96]
CD109 OTDADBM4 moderate Biomarker [97]
CIB2 OT9ZJX1I moderate Genetic Variation [98]
KRT7 OTLT3JFN moderate Biomarker [99]
MAD2L1 OTXNGZCG moderate Altered Expression [100]
PLIN2 OTRXJ9UN moderate Altered Expression [22]
PRF1 OTFVXD7H moderate Genetic Variation [101]
SMARCB1 OT2LP7LJ moderate Biomarker [102]
STK3 OTLNSCQD moderate Biomarker [103]
TPM4 OTN4YLYR moderate Biomarker [104]
AADAC OT8VACT2 Strong Altered Expression [105]
ABRAXAS1 OT1K4J80 Strong Genetic Variation [106]
ACAN OTUOCW8K Strong Biomarker [107]
ADARB1 OTGKSZEV Strong Altered Expression [108]
ADGRG2 OTPAD5S1 Strong Altered Expression [109]
AFAP1L1 OTWNTNDB Strong Biomarker [110]
AHRR OTSJ12W6 Strong Biomarker [50]
AMFR OTQRX7LC Strong Altered Expression [111]
ARAP1 OTINOJJ7 Strong Biomarker [43]
ARHGAP1 OT0H2ZBZ Strong Biomarker [43]
ARSF OTC0L12N Strong Altered Expression [112]
ATRX OT77RSQW Strong Biomarker [113]
BATF3 OTI61WXQ Strong Biomarker [114]
BTC OTW4B2O0 Strong Genetic Variation [115]
C16orf96 OTE0B1QV Strong Biomarker [71]
CALB2 OTSNMCG9 Strong Altered Expression [116]
CALD1 OTNJKJ6Q Strong Biomarker [117]
CAPN6 OT8K5PR5 Strong Altered Expression [118]
CAVIN2 OTFHHDRU Strong Biomarker [119]
CBX3 OTOP9RLD Strong Altered Expression [120]
CCAR2 OTLUDG5T Strong Biomarker [121]
CCS OTXHT3QO Strong Biomarker [122]
CD3D OTRBLP0R Strong Altered Expression [33]
CD99 OTPUZ5DE Strong Altered Expression [123]
CMAS OTFQJG3C Strong Biomarker [124]
CNMD OTHND8EL Strong Biomarker [125]
COL9A1 OTWBR27Y Strong Altered Expression [126]
COL9A2 OT1ZBDBV Strong Altered Expression [126]
COL9A3 OTCUJOEK Strong Altered Expression [126]
COPB2 OT82JIGC Strong Biomarker [127]
CTAG1B OTIQGW6U Strong Biomarker [40]
CUL4A OTTBV70J Strong Altered Expression [128]
CYFIP2 OTCAY35T Strong Biomarker [129]
DCLRE1C OTW3KB1I Strong Biomarker [130]
DCTN1 OT5B51FJ Strong Genetic Variation [88]
DDIT3 OTI8YKKE Strong Biomarker [131]
DDX53 OTHK3EGZ Strong Biomarker [132]
DES OTI09KBW Strong Biomarker [133]
DROSHA OTCE68KZ Strong Genetic Variation [89]
DUSP12 OT8WB1YB Strong Biomarker [134]
DYNLL1 OTR69LHT Strong Biomarker [135]
EEF1E1 OTRA6XOB Strong Genetic Variation [29]
ENDOU OTB7OF7Y Strong Genetic Variation [136]
ESD OTUSIBPS Strong Altered Expression [137]
ESPL1 OTMGEVOK Strong Biomarker [138]
ETV4 OT8C98UZ Strong Biomarker [139]
ETV5 OTE2OBM4 Strong Genetic Variation [139]
EXOSC6 OTAC10N6 Strong Genetic Variation [136]
FAU OTGTVOWK Strong Altered Expression [140]
FBP2 OT9R1LF7 Strong Altered Expression [141]
FBXW4 OTEGSZOX Strong Altered Expression [105]
FEV OTYEC4IR Strong Biomarker [142]
FGFRL1 OT8HZ3ZL Strong Altered Expression [143]
FLCN OTVM78XM Strong Biomarker [136]
FLII OT7G9JG6 Strong Biomarker [80]
FOXL2 OTFRQUYL Strong Biomarker [144]
FOXO4 OT90X9LN Strong Biomarker [145]
GPC5 OT8NR7GC Strong Biomarker [146]
HAUS8 OTLEFUOA Strong Biomarker [147]
HIRA OTON40EJ Strong Biomarker [51]
HNRNPM OTFU3OEZ Strong Altered Expression [148]
JAZF1 OTXTYSYD Strong Genetic Variation [149]
KCNK6 OTCY281R Strong Biomarker [150]
KIF22 OTY6X6BL Strong Biomarker [151]
KLF3 OTIIAC18 Strong Altered Expression [152]
LAMTOR1 OTIBJBW9 Strong Genetic Variation [29]
LARP6 OTUQ9QS9 Strong Biomarker [153]
LCP1 OTK61F2A Strong Biomarker [154]
LRRC15 OTX7JL8H Strong Altered Expression [155]
MAFK OTZJUE4P Strong Genetic Variation [29]
MAML3 OTZFV53Z Strong Biomarker [156]
MCM3 OTOOHQPM Strong Biomarker [127]
MEF2A OTV2SF6E Strong Biomarker [157]
MGA OTTLB216 Strong Genetic Variation [158]
MPIG6B OTVNKQWA Strong Genetic Variation [159]
MRTFB OT9OXGS9 Strong Biomarker [160]
MUC6 OTPVL723 Strong Biomarker [161]
MYL12B OTXMLQOT Strong Altered Expression [162]
MYL2 OT78PC0C Strong Altered Expression [162]
MYL9 OT6B22JB Strong Altered Expression [162]
MYOD1 OTV2S79X Strong Genetic Variation [163]
MYOG OTPLJKFA Strong Biomarker [160]
NANS OTMQ2FUH Strong Biomarker [164]
NAPSA OT6F8IAL Strong Altered Expression [165]
NFATC2 OTK5T6HZ Strong Biomarker [166]
NKX2-2 OTDCOYNG Strong Altered Expression [167]
NMB OT4NLN6H Strong Altered Expression [168]
OBP2A OTBIJ5TI Strong Biomarker [151]
ODF2L OTJLJ65L Strong Biomarker [169]
OS9 OTB5B2TY Strong Genetic Variation [170]
P2RX6 OT1FNTXA Strong Altered Expression [171]
PARP9 OT7K4494 Strong Biomarker [73]
PATZ1 OT0X9WGR Strong Biomarker [172]
PAX3 OTN5PJZV Strong Biomarker [173]
PAX7 OTDMQRPO Strong Biomarker [174]
PHF11 OT5F6LUP Strong Biomarker [169]
PIK3AP1 OTMW1B47 Strong Biomarker [169]
PLPP2 OT0BQAXX Strong Altered Expression [108]
PMS2 OTNLWTMI Strong Biomarker [175]
POT1 OTNBXJCQ Strong Genetic Variation [176]
POU4F1 OTMHYGWQ Strong Altered Expression [68]
PPP1R11 OTSHYPPW Strong Biomarker [177]
PRAP1 OT48QD82 Strong Biomarker [178]
PSMD4 OTH1VZTM Strong Altered Expression [112]
PTPRG OT9N2WOF Strong Genetic Variation [179]
PTTG1IP OTX21QTE Strong Altered Expression [180]
RBM38 OTPO8EXU Strong Altered Expression [181]
RBP1 OTRP1MFC Strong Biomarker [182]
RITA1 OTUH8IPS Strong Biomarker [183]
RND3 OTXMXPIH Strong Biomarker [184]
ROM1 OTE7H0YV Strong Biomarker [185]
RRBP1 OT4ZTPTM Strong Genetic Variation [88]
RREB1 OT62460U Strong Biomarker [160]
RUSC2 OT0EKMVR Strong Biomarker [58]
SCG2 OTXWUQQL Strong Biomarker [186]
SERPINB9 OTJ811IF Strong Biomarker [70]
SH2B1 OTJZO2CI Strong Biomarker [187]
SLAMF1 OTBTT3ZQ Strong Biomarker [188]
SLURP1 OT89YD2E Strong Biomarker [189]
SP3 OTYDQZ1T Strong Altered Expression [190]
SSX1 OTZ7NRCY Strong Genetic Variation [191]
SSX2 OT2Z6RLL Strong Biomarker [192]
SYN1 OTMNPWC1 Strong Biomarker [193]
TAF12 OTQZII5O Strong Genetic Variation [194]
TCL1B OT4CSO39 Strong Biomarker [193]
TFE3 OTM99ZWH Strong Altered Expression [195]
TLE1 OT50MRZ1 Strong Altered Expression [123]
TPPP2 OTI3WA6X Strong Genetic Variation [29]
TPPP3 OTU8VUIG Strong Biomarker [95]
TSPAN31 OT8WQ83R Strong Biomarker [164]
TTF1 OT4K90WD Strong Biomarker [196]
TTL OTSS1CK4 Strong Biomarker [197]
MAML2 OT1TSVAR Definitive Biomarker [198]
------------------------------------------------------------------------------------
⏷ Show the Full List of 172 DOT(s)

References

1 Mllerian inhibiting substance type II receptor (MISIIR): a novel, tissue-specific target expressed by gynecologic cancers.Gynecol Oncol. 2008 Jan;108(1):141-8. doi: 10.1016/j.ygyno.2007.09.010. Epub 2007 Nov 7.
2 Cytogenetics and experimental models.Curr Opin Oncol. 1996 Jul;8(4):284-8. doi: 10.1097/00001622-199607000-00004.
3 An update on the central nervous system manifestations of DICER1 syndrome.Acta Neuropathol. 2020 Apr;139(4):689-701. doi: 10.1007/s00401-019-01997-y. Epub 2019 Apr 5.
4 Analysis of HIF-1a and its regulator, PHD2, in retroperitoneal sarcomas: clinico-pathologic implications.Cancer Biol Ther. 2010 Feb;9(4):303-11. doi: 10.4161/cbt.9.4.10744. Epub 2009 Dec 22.
5 Neuron navigator-2 and cyclin D2 are new candidate prognostic markers in uterine sarcoma.Virchows Arch. 2017 Sep;471(3):355-362. doi: 10.1007/s00428-017-2172-5. Epub 2017 Jun 22.
6 Integral membrane protease fibroblast activation protein sensitizes fibrosarcoma to chemotherapy and alters cell death mechanisms.Apoptosis. 2015 Nov;20(11):1483-98. doi: 10.1007/s10495-015-1166-5.
7 Assessment of Molecular Markers in AML Patients: A Hospital-Based Study in Lebanon.Clin Lymphoma Myeloma Leuk. 2015 Jun;15 Suppl:S80-4. doi: 10.1016/j.clml.2015.02.011.
8 IGF1-R signals through the RON receptor to mediate pancreatic cancer cell migration.Carcinogenesis. 2011 Aug;32(8):1151-6. doi: 10.1093/carcin/bgr086. Epub 2011 May 11.
9 Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity.Oncogene. 2001 Oct 18;20(47):6881-90. doi: 10.1038/sj.onc.1204874.
10 Uterine and vaginal sarcomas resembling fibrosarcoma: a clinicopathological and molecular analysis of 13 cases showing common NTRK-rearrangements and the description of a COL1A1-PDGFB fusion novel to uterine neoplasms.Mod Pathol. 2019 Jul;32(7):1008-1022. doi: 10.1038/s41379-018-0184-6. Epub 2019 Mar 16.
11 A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.Cancer Res. 2019 Apr 15;79(8):1981-1995. doi: 10.1158/0008-5472.CAN-18-1984. Epub 2019 Feb 18.
12 From PTEN loss of expression to RICTOR role in smooth muscle differentiation: complex involvement of the mTOR pathway in leiomyosarcomas and pleomorphic sarcomas.Mod Pathol. 2012 Feb;25(2):197-211. doi: 10.1038/modpathol.2011.163. Epub 2011 Nov 11.
13 Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma.Br J Cancer. 2017 Dec 5;117(12):1787-1797. doi: 10.1038/bjc.2017.354. Epub 2017 Oct 12.
14 Selinexor (KPT-330) Induces Tumor Suppression through Nuclear Sequestration of IB and Downregulation of Survivin.Clin Cancer Res. 2017 Aug 1;23(15):4301-4311. doi: 10.1158/1078-0432.CCR-16-2632. Epub 2017 Mar 17.
15 Interleukin (IL)-3/granulocyte macrophage-colony stimulating factor/IL-5 receptor alpha and beta chains are preferentially expressed in acute myeloid leukaemias with mutated FMS-related tyrosine kinase 3 receptor.Br J Haematol. 2009 Feb;144(3):376-87. doi: 10.1111/j.1365-2141.2008.07491.x. Epub 2008 Nov 13.
16 Frequent loss of claudin-4 expression in dedifferentiated and undifferentiated endometrial carcinomas.Histopathology. 2018 Aug;73(2):299-305. doi: 10.1111/his.13525. Epub 2018 May 31.
17 Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage.J Biol Chem. 2018 Feb 16;293(7):2466-2475. doi: 10.1074/jbc.M117.805051. Epub 2017 Dec 1.
18 New fusion sarcomas: histopathology and clinical significance of selected entities.Hum Pathol. 2019 Apr;86:57-65. doi: 10.1016/j.humpath.2018.12.006. Epub 2019 Jan 8.
19 Disruption of CXCR2-mediated MDSC tumor trafficking enhances anti-PD1 efficacy.Sci Transl Med. 2014 May 21;6(237):237ra67. doi: 10.1126/scitranslmed.3007974.
20 The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis.J Pathol. 2017 Mar;241(4):501-510. doi: 10.1002/path.4854. Epub 2017 Jan 6.
21 NAC1, a BTB/POZ protein overexpressed in uterine sarcomas.Anticancer Res. 2012 Sep;32(9):3841-5.
22 Perilipin 1 is a highly specific marker for adipocytic differentiation in sarcomas with intermediate sensitivity.J Cancer Res Clin Oncol. 2017 Feb;143(2):225-232. doi: 10.1007/s00432-016-2263-8. Epub 2016 Sep 19.
23 Receptor tyrosine kinase gene expression profiles of Ewing sarcomas reveal ROR1 as a potential therapeutic target in metastatic disease.Mol Oncol. 2016 May;10(5):677-92. doi: 10.1016/j.molonc.2015.12.009. Epub 2015 Dec 20.
24 Frequent absence of tumor suppressor FUS1 protein expression in human bone and soft tissue sarcomas.Anticancer Res. 2011 Jan;31(1):11-21.
25 High expression of the evolutionarily conserved alpha/beta hydrolase domain containing 6 (ABHD6) in Ewing tumors.Cancer Sci. 2009 Dec;100(12):2383-9. doi: 10.1111/j.1349-7006.2009.01347.x. Epub 2009 Sep 4.
26 Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions.J Clin Invest. 2009 Jun;119(6):1727-40. doi: 10.1172/JCI37127. Epub 2009 May 18.
27 YAP1-Mediated Suppression of USP31 Enhances NFB Activity to Promote Sarcomagenesis.Cancer Res. 2018 May 15;78(10):2705-2720. doi: 10.1158/0008-5472.CAN-17-4052. Epub 2018 Feb 28.
28 Expression of dog1 in low-grade fibromyxoid sarcoma: A study of 19 cases and review of the literature.Ann Diagn Pathol. 2017 Oct;30:8-11. doi: 10.1016/j.anndiagpath.2017.05.002. Epub 2017 May 11.
29 Alterations of the p15, p16,and p18 genes in osteosarcoma.Cancer Genet Cytogenet. 1996 Feb;86(2):136-42. doi: 10.1016/0165-4608(95)00216-2.
30 Synthesis and Investigation of Photophysical and Biological Properties of Novel S-Containing Bacteriopurpurinimides.J Med Chem. 2017 Dec 28;60(24):10220-10230. doi: 10.1021/acs.jmedchem.7b00577. Epub 2017 Dec 18.
31 Tumour endothelial marker 1/endosialin-mediated targeting of human sarcoma.Eur J Cancer. 2018 Feb;90:111-121. doi: 10.1016/j.ejca.2017.10.035. Epub 2018 Jan 4.
32 Exceptionally rapid response to pembrolizumab in a SMARCA4-deficient thoracic sarcoma overexpressing PD-L1: A case report.Thorac Cancer. 2019 Dec;10(12):2312-2315. doi: 10.1111/1759-7714.13215. Epub 2019 Oct 16.
33 A systematic analysis of immune genes and overall survival in cancer patients.BMC Cancer. 2019 Dec 16;19(1):1225. doi: 10.1186/s12885-019-6414-6.
34 Co-expression of MDM2 and CDK4 in transformed human mesenchymal stem cells causes high-grade sarcoma with a dedifferentiated liposarcoma-like morphology.Lab Invest. 2019 Sep;99(9):1309-1320. doi: 10.1038/s41374-019-0263-4. Epub 2019 Jun 3.
35 Quantitative proteomic profiling of pleomorphic human sarcoma identifies CLIC1 as a dominant pro-oncogenic receptor expressed in diverse sarcoma types.J Proteome Res. 2014 May 2;13(5):2543-59. doi: 10.1021/pr4010713. Epub 2014 Apr 9.
36 Carboxypeptidase E: elevated expression correlated with tumor growth and metastasis in pheochromocytomas and other cancers.Cell Mol Neurobiol. 2010 Nov;30(8):1377-81. doi: 10.1007/s10571-010-9592-y.
37 Genetic analyses of undifferentiated small round cell sarcoma identifies a novel sarcoma subtype with a recurrent CRTC1-SS18 gene fusion.J Pathol. 2018 Jun;245(2):186-196. doi: 10.1002/path.5071. Epub 2018 Apr 16.
38 FMS Kinase Inhibitors: Current Status and Future Prospects.Med Res Rev. 2013 May;33(3):599-636. doi: 10.1002/med.21258. Epub 2012 Mar 20.
39 Hepatitis B virus core protein promotes hepatocarcinogenesis by enhancing Src expression and activating the Src/PI3K/Akt pathway.FASEB J. 2018 Jun;32(6):3033-3046. doi: 10.1096/fj.201701144R. Epub 2018 Jan 17.
40 A Pilot Trial of the Combination of Transgenic NY-ESO-1-reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab.Clin Cancer Res. 2019 Apr 1;25(7):2096-2108. doi: 10.1158/1078-0432.CCR-18-3496. Epub 2018 Dec 20.
41 Identification of EML4-ALK as an alternative fusion gene in epithelioid inflammatory myofibroblastic sarcoma.Orphanet J Rare Dis. 2017 May 23;12(1):97. doi: 10.1186/s13023-017-0647-8.
42 Fusion gene addiction: can tumours be forced to give up the habit?.J Pathol. 2017 Jul;242(3):263-266. doi: 10.1002/path.4902. Epub 2017 May 29.
43 Expression profiles of signal transduction genes in ex vivo drug-resistant pediatric acute lymphoblastic leukemia.Anticancer Res. 2012 Feb;32(2):503-6.
44 Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome.PLoS One. 2013 Sep 13;8(9):e75478. doi: 10.1371/journal.pone.0075478. eCollection 2013.
45 YB-1 regulates stress granule formation and tumor progression by translationally activating G3BP1.J Cell Biol. 2015 Mar 30;208(7):913-29. doi: 10.1083/jcb.201411047. Epub 2015 Mar 23.
46 Meta-analysis of genome-wide association studies on the intolerance of angiotensin-converting enzyme inhibitors.Pharmacogenet Genomics. 2017 Mar;27(3):112-119. doi: 10.1097/FPC.0000000000000264.
47 Dasatinib Inhibits Procoagulant and Clot Retracting Activities of Human Platelets.Int J Mol Sci. 2019 Oct 31;20(21):5430. doi: 10.3390/ijms20215430.
48 Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2.Mol Cell Biol. 2016 Sep 12;36(19):2503-13. doi: 10.1128/MCB.00373-16. Print 2016 Oct 1.
49 Integrative genomic analyses of the histamine H1 receptor and its role in cancer prediction.Int J Mol Med. 2014 Apr;33(4):1019-26. doi: 10.3892/ijmm.2014.1649. Epub 2014 Feb 10.
50 Fusion of the AHRR and NCOA2 genes through a recurrent translocation t(5;8)(p15;q13) in soft tissue angiofibroma results in upregulation of aryl hydrocarbon receptor target genes.Genes Chromosomes Cancer. 2012 May;51(5):510-20. doi: 10.1002/gcc.21939. Epub 2012 Feb 15.
51 Activation of transforming potential of the human insulin receptor gene.Proc Natl Acad Sci U S A. 1987 Aug;84(16):5725-9. doi: 10.1073/pnas.84.16.5725.
52 The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib.Front Oncol. 2019 Jul 18;9:650. doi: 10.3389/fonc.2019.00650. eCollection 2019.
53 Feasibility of laparoscopic isolated caudate lobe resection for rare hepatic mesenchymal neoplasms.World J Clin Cases. 2019 Oct 26;7(20):3194-3201. doi: 10.12998/wjcc.v7.i20.3194.
54 The tyrosine kinase p56lck is essential in coxsackievirus B3-mediated heart disease.Nat Med. 2000 Apr;6(4):429-34. doi: 10.1038/74689.
55 A novel triazolonaphthalimide induces apoptosis and inhibits tumor growth by targeting DNA and DNA-associated processes.Oncotarget. 2017 Jun 6;8(23):37394-37408. doi: 10.18632/oncotarget.16962.
56 MAGE-A3 is a Clinically Relevant Target in Undifferentiated Pleomorphic Sarcoma/Myxofibrosarcoma.Cancers (Basel). 2019 May 15;11(5):677. doi: 10.3390/cancers11050677.
57 Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IB.PLoS One. 2012;7(12):e52782. doi: 10.1371/journal.pone.0052782. Epub 2012 Dec 28.
58 Copy number alterations and neoplasia-specific mutations in MELK, PDCD1LG2, TLN1, and PAX5 at 9p in different neoplasias.Genes Chromosomes Cancer. 2014 Jul;53(7):579-88. doi: 10.1002/gcc.22168. Epub 2014 Mar 24.
59 The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-... Mol Cell Biol. 2009 Nov;29(21):5872-88.
60 Investigating a chimeric anti-mouse PDGFR antibody as a radiosensitizer in primary mouse sarcomas.EBioMedicine. 2019 Feb;40:224-230. doi: 10.1016/j.ebiom.2019.01.046. Epub 2019 Jan 31.
61 p53 gene mutation and loss of heterozygosity of chromosome 11 in methylcholanthrene-induced mouse sarcomas.Jpn J Cancer Res. 1998 Mar;89(3):269-77. doi: 10.1111/j.1349-7006.1998.tb00558.x.
62 Diagnosis of known sarcoma fusions and novel fusion partners by targeted RNA sequencing with identification of a recurrent ACTB-FOSB fusion in pseudomyogenic hemangioendothelioma.Mod Pathol. 2019 May;32(5):609-620. doi: 10.1038/s41379-018-0175-7. Epub 2018 Nov 21.
63 Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous Kras(G12D).Sci Rep. 2019 Nov 20;9(1):17220. doi: 10.1038/s41598-019-53572-w.
64 Uterine mesenchymal tumours: recent advances.Histopathology. 2020 Jan;76(1):64-75. doi: 10.1111/his.14008.
65 Current knowledge of mechanisms of viral carcinogenesis.Crit Rev Toxicol. 1984;13(2):197-204. doi: 10.3109/10408448409034082.
66 p27kip1 expression limits H-Ras-driven transformation and tumorigenesis by both canonical and non-canonical mechanisms.Oncotarget. 2016 Oct 4;7(40):64560-64574. doi: 10.18632/oncotarget.11656.
67 Death Receptor 6 (DR6) Is Overexpressed in Astrocytomas.Anticancer Res. 2019 May;39(5):2299-2306. doi: 10.21873/anticanres.13346.
68 A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.Nucleic Acids Res. 1992 Sep 25;20(18):4919-25. doi: 10.1093/nar/20.18.4919.
69 MiR-199a suppresses prostate cancer paclitaxel resistance by targeting YES1. World J Urol. 2018 Mar;36(3):357-365.
70 Next generation sequencing analysis of miRNAs: MiR-127-3p inhibits glioblastoma proliferation and activates TGF- signaling by targeting SKI.OMICS. 2014 Mar;18(3):196-206. doi: 10.1089/omi.2013.0122. Epub 2014 Feb 11.
71 Identification of novel sarcoma risk genes using a two-stage genome wide DNA sequencing strategy in cancer cluster families and population case and control cohorts.BMC Med Genet. 2019 May 3;20(1):69. doi: 10.1186/s12881-019-0808-9.
72 GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study.Ann Oncol. 2013 Nov;24(11):2922-6. doi: 10.1093/annonc/mdt391.
73 Definition of the human raf amino-terminal regulatory region by deletion mutagenesis.Mol Cell Biol. 1989 Feb;9(2):639-47. doi: 10.1128/mcb.9.2.639-647.1989.
74 The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells.Mol Cell Biochem. 2018 Nov;448(1-2):275-286. doi: 10.1007/s11010-018-3332-x. Epub 2018 Feb 15.
75 MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions.Tumour Biol. 2010 Jun;31(3):157-63. doi: 10.1007/s13277-010-0021-0. Epub 2010 Mar 6.
76 Pol deficiency induces moderate shortening of P53(-/-) mouse lifespan and modifies tumor spectrum.DNA Repair (Amst). 2017 Jun;54:40-45. doi: 10.1016/j.dnarep.2017.04.001. Epub 2017 Apr 10.
77 Disruption of mammalian SWI/SNF and polycomb complexes in human sarcomas: mechanisms and therapeutic opportunities.J Pathol. 2018 Apr;244(5):638-649. doi: 10.1002/path.5042. Epub 2018 Mar 6.
78 Prognostic role of XTP1/DEPDC1B and SDP35/DEPDC1A in high grade soft-tissue sarcomas.Histol Histopathol. 2018 Jun;33(6):597-608. doi: 10.14670/HH-11-959. Epub 2018 Jan 3.
79 Trabectedin in patients with advanced non-small-cell lung cancer (NSCLC) with XPG and/or ERCC1 overexpression and BRCA1 underexpression and pretreated with platinum.Lung Cancer. 2012 Jun;76(3):354-61. doi: 10.1016/j.lungcan.2011.12.002. Epub 2011 Dec 23.
80 FLI-1 distinguishes Ewing sarcoma from small cell osteosarcoma and mesenchymal chondrosarcoma.Appl Immunohistochem Mol Morphol. 2011 May;19(3):233-8. doi: 10.1097/PAI.0b013e3181fd6697.
81 The Hippo signal transduction pathway in soft tissue sarcomas.Biochim Biophys Acta. 2015 Aug;1856(1):121-9. doi: 10.1016/j.bbcan.2015.05.006. Epub 2015 Jun 4.
82 Neoplastic Transformation of Human Mesenchymal Stromal Cells Mediated via LIN28B.Sci Rep. 2019 May 30;9(1):8101. doi: 10.1038/s41598-019-44536-1.
83 Diagnostic utility of NCOA2 fluorescence in situ hybridization and Stat6 immunohistochemistry staining for soft tissue angiofibroma and morphologically similar fibrovascular tumors.Hum Pathol. 2014 Aug;45(8):1588-96. doi: 10.1016/j.humpath.2013.12.022. Epub 2014 Apr 18.
84 Elevated NDC80 expression is associated with poor prognosis in osteosarcoma patients.Eur Rev Med Pharmacol Sci. 2017 May;21(9):2045-2053.
85 Associations of clock genes polymorphisms with soft tissue sarcoma susceptibility and prognosis.J Transl Med. 2018 Dec 5;16(1):338. doi: 10.1186/s12967-018-1715-0.
86 NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.Hum Pathol. 2017 Jul;65:225-230. doi: 10.1016/j.humpath.2017.01.012. Epub 2017 Feb 8.
87 TGFBR3 and MGEA5 rearrangements are much more common in "hybrid" hemosiderotic fibrolipomatous tumor-myxoinflammatory fibroblastic sarcomas than in classical myxoinflammatory fibroblastic sarcomas: a morphological and fluorescence in situ hybridization study.Hum Pathol. 2016 Jul;53:14-24. doi: 10.1016/j.humpath.2016.02.005. Epub 2016 Mar 2.
88 ALK oncoproteins in atypical inflammatory myofibroblastic tumours: novel RRBP1-ALK fusions in epithelioid inflammatory myofibroblastic sarcoma.J Pathol. 2017 Feb;241(3):316-323. doi: 10.1002/path.4836. Epub 2016 Dec 15.
89 Sequencing of DICER1 in sarcomas identifies biallelic somatic DICER1 mutations in an adult-onset embryonal rhabdomyosarcoma.Br J Cancer. 2017 Jun 6;116(12):1621-1626. doi: 10.1038/bjc.2017.147. Epub 2017 May 18.
90 Emerging Targeted and Immune-Based Therapies in Sarcoma.J Clin Oncol. 2018 Jan 10;36(2):125-135. doi: 10.1200/JCO.2017.75.1610. Epub 2017 Dec 8.
91 Genetic alterations in the RAS/RAF/mitogen-activated protein kinase and phosphatidylinositol 3-kinase/Akt signaling pathways in the follicular variant of papillary thyroid carcinoma.Cancer. 2010 Jun 15;116(12):2974-83. doi: 10.1002/cncr.25061.
92 Rapamycin may inhibit murine S180 sarcoma growth by regulating the pathways associated with autophagy and cancer stem cells.J Cancer Res Ther. 2019;15(2):398-403. doi: 10.4103/jcrt.JCRT_639_18.
93 TopBP1 promotes malignant progression and correlates with poor prognosis in osteosarcoma.Eur Rev Med Pharmacol Sci. 2017 Sep;21(18):4022-4031.
94 Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas.Genomics. 1995 Jan 20;25(2):501-6. doi: 10.1016/0888-7543(95)80051-m.
95 Cell-type dependent enhancer binding of the EWS/ATF1 fusion gene in clear cell sarcomas.Nat Commun. 2019 Sep 5;10(1):3999. doi: 10.1038/s41467-019-11745-1.
96 Inactivation of the tumor suppressor WTX in a subset of pediatric tumors.Genes Chromosomes Cancer. 2014 Jan;53(1):67-77. doi: 10.1002/gcc.22118. Epub 2013 Nov 5.
97 High expression of CD109 antigen regulates the phenotype of cancer stem-like cells/cancer-initiating cells in the novel epithelioid sarcoma cell line ESX and is related to poor prognosis of soft tissue sarcoma.PLoS One. 2013 Dec 20;8(12):e84187. doi: 10.1371/journal.pone.0084187. eCollection 2013.
98 Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors.Cancer Res. 1996 Mar 15;56(6):1219-21.
99 Differential gene expression identifies KRT7 and MUC1 as potential metastasis-specific targets in sarcoma.Cancer Manag Res. 2019 Sep 9;11:8209-8218. doi: 10.2147/CMAR.S218676. eCollection 2019.
100 Aberrant MAD2 expression in soft-tissue sarcoma.Pathol Int. 2008 Jun;58(6):329-33. doi: 10.1111/j.1440-1827.2008.02232.x.
101 High Level of Perforin Expression Is Required for Effective Correction of Hemophagocytic Lymphohistiocytosis.Hum Gene Ther. 2016 Oct;27(10):847-859. doi: 10.1089/hum.2016.065. Epub 2016 Jul 29.
102 Sarcoma in neurofibromatosis 2: case report and review of the literature.Fam Cancer. 2019 Jan;18(1):97-100. doi: 10.1007/s10689-018-0084-4.
103 Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma.Mol Carcinog. 2007 Oct;46(10):865-71. doi: 10.1002/mc.20317.
104 Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma.J Hematol Oncol. 2014 Oct 10;7:76. doi: 10.1186/s13045-014-0076-2.
105 Decitabine facilitates immune recognition of sarcoma cells by upregulating CT antigens, MHC molecules, and ICAM-1.Tumour Biol. 2014 Jun;35(6):5753-62. doi: 10.1007/s13277-014-1764-9. Epub 2014 Mar 2.
106 Kaposi Sarcoma in Association With an Extracavitary Primary Effusion Lymphoma Showing Unusual Intravascular Involvement: Report of a Case Harboring a FAM175A Germline Mutation.Am J Dermatopathol. 2020 Jan;42(1):55-60. doi: 10.1097/DAD.0000000000001491.
107 Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.J Immunol. 1993 Dec 15;151(12):7161-71.
108 Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.Mol Cancer Ther. 2009 Jan;8(1):249-60. doi: 10.1158/1535-7163.MCT-08-0636.
109 G-Protein coupled receptor 64 promotes invasiveness and metastasis in Ewing sarcomas through PGF and MMP1.J Pathol. 2013 May;230(1):70-81. doi: 10.1002/path.4170. Epub 2013 Mar 14.
110 Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas.Oncogene. 2011 Sep 22;30(38):4015-25. doi: 10.1038/onc.2011.108. Epub 2011 Apr 25.
111 The ubiquitin ligase gp78 promotes sarcoma metastasis by targeting KAI1 for degradation.Nat Med. 2007 Dec;13(12):1504-9. doi: 10.1038/nm1686. Epub 2007 Nov 25.
112 The gene encoding the splicing factor SF2/ASF is a proto-oncogene.Nat Struct Mol Biol. 2007 Mar;14(3):185-93. doi: 10.1038/nsmb1209. Epub 2007 Feb 18.
113 Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.PLoS Genet. 2019 Apr 10;15(4):e1008039. doi: 10.1371/journal.pgen.1008039. eCollection 2019 Apr.
114 Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation.Cancer Immunol Res. 2019 Jan;7(1):29-39. doi: 10.1158/2326-6066.CIR-18-0138. Epub 2018 Nov 27.
115 Correlating programmed death ligand 1 (PD-L1) expression, mismatch repair deficiency, and outcomes across tumor types: implications for immunotherapy.Oncotarget. 2017 Aug 24;8(44):77415-77423. doi: 10.18632/oncotarget.20492. eCollection 2017 Sep 29.
116 CIC-rearranged Sarcomas: A Study of 20 Cases and Comparisons With Ewing Sarcomas.Am J Surg Pathol. 2016 Mar;40(3):313-23. doi: 10.1097/PAS.0000000000000570.
117 Primary leiomyosarcoma of the spine: A case report and literature review.Medicine (Baltimore). 2017 Mar;96(9):e6227. doi: 10.1097/MD.0000000000006227.
118 Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.JCI Insight. 2018 Sep 6;3(17):e121225. doi: 10.1172/jci.insight.121225. eCollection 2018 Sep 6.
119 A systematic analysis reveals gene expression alteration of serum deprivation response (SDPR) gene is significantly associated with the survival of patients with cancer.Oncol Rep. 2019 Sep;42(3):1161-1172. doi: 10.3892/or.2019.7212. Epub 2019 Jun 26.
120 CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma.Mol Med Rep. 2019 May;19(5):4205-4212. doi: 10.3892/mmr.2019.10104. Epub 2019 Mar 28.
121 Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas.PLoS One. 2013 Sep 3;8(9):e74738. doi: 10.1371/journal.pone.0074738. eCollection 2013.
122 Clear cell sarcoma of the gastrointestinal tract and malignant gastrointestinal neuroectodermal tumour: distinct or related entities? A review.Pathology. 2018 Aug;50(5):490-498. doi: 10.1016/j.pathol.2018.05.001. Epub 2018 Jun 30.
123 Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes.Virchows Arch. 2017 Apr;470(4):373-380. doi: 10.1007/s00428-017-2072-8. Epub 2017 Feb 14.
124 The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications.J Intern Med. 2009 Jul;266(1):43-52. doi: 10.1111/j.1365-2796.2009.02110.x.
125 Novel quinolone CHM-1 induces apoptosis and inhibits metastasis in a human osterogenic sarcoma cell line.J Orthop Res. 2009 Dec;27(12):1637-44. doi: 10.1002/jor.20937.
126 S-MED: sarcoma microRNA expression database.Lab Invest. 2010 May;90(5):753-61. doi: 10.1038/labinvest.2010.53. Epub 2010 Mar 8.
127 Engineering and characterization of a single-chain antibody fragment (scFV1924) against the human sarcoma-associated antigen p102.Anticancer Res. 2000 Jul-Aug;20(4):2753-60.
128 Analysis of DNA repair-related genes in breast cancer reveals CUL4A ubiquitin ligase as a novel biomarker of trabectedin response.Mol Cancer Ther. 2013 Apr;12(4):530-41. doi: 10.1158/1535-7163.MCT-12-0768. Epub 2013 Jan 30.
129 MDM2 and p21WAF1/CIP1, wild-type p53-induced proteins, are regularly expressed by Sternberg-Reed cells in Hodgkin's disease.J Pathol. 1996 Sep;180(1):58-64. doi: 10.1002/(SICI)1096-9896(199609)180:1<58::AID-PATH610>3.0.CO;2-W.
130 ARTEMIS stabilizes the genome and modulates proliferative responses in multipotent mesenchymal cells.BMC Biol. 2010 Oct 27;8:132. doi: 10.1186/1741-7007-8-132.
131 DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2.BMC Cell Biol. 2009 Dec 17;10:89. doi: 10.1186/1471-2121-10-89.
132 Murine carcinoma expressing carcinoembryonic antigen-like protein is restricted by antibody against neem leaf glycoprotein.Immunol Lett. 2014 Nov;162(1 Pt A):132-9. doi: 10.1016/j.imlet.2014.08.004. Epub 2014 Aug 13.
133 CIC-DUX4 sarcoma diagnosed by fine-needle aspiration cytology: A case report.Diagn Cytopathol. 2018 Nov;46(11):958-963. doi: 10.1002/dc.24027. Epub 2018 Oct 24.
134 Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH.Mol Cancer. 2005 Nov 7;4:39. doi: 10.1186/1476-4598-4-39.
135 Stromal activation associated with development of prostate cancer in prostate-targeted fibroblast growth factor 8b transgenic mice.Neoplasia. 2010 Nov;12(11):915-27. doi: 10.1593/neo.10776.
136 Loss of TP53 in sarcomas with 17p12 to approximately p11 gain. A fine-resolution oligonucleotide array comparative genomic hybridization study.Cytogenet Genome Res. 2007;116(3):153-7. doi: 10.1159/000098180.
137 Chromosome 13 instability and esterase D expression in an osteosarcoma cell line.Cancer Genet Cytogenet. 1987 Feb;24(2):327-34. doi: 10.1016/0165-4608(87)90115-4.
138 Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice.PLoS One. 2011;6(7):e22167. doi: 10.1371/journal.pone.0022167. Epub 2011 Jul 25.
139 The utility of ETV1, ETV4 and ETV5 RNA in-situ hybridization in the diagnosis of CIC-DUX sarcomas.Histopathology. 2017 Mar;70(4):657-663. doi: 10.1111/his.13112. Epub 2016 Dec 16.
140 fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus.Oncogene. 1993 Sep;8(9):2537-46.
141 Fructose-1,6-Bisphosphatase 2 Inhibits Sarcoma Progression by Restraining Mitochondrial Biogenesis.Cell Metab. 2020 Jan 7;31(1):174-188.e7. doi: 10.1016/j.cmet.2019.10.012. Epub 2019 Nov 21.
142 Ewing sarcoma with novel translocation t(2;16) producing an in-frame fusion of FUS and FEV.J Mol Diagn. 2007 Sep;9(4):459-63. doi: 10.2353/jmoldx.2007.070009. Epub 2007 Jul 9.
143 Canine and human sarcomas exhibit predominant FGFR1 expression and impaired viability after inhibition of signaling.Mol Carcinog. 2015 Sep;54(9):841-52. doi: 10.1002/mc.22155. Epub 2014 Apr 9.
144 Mutational analysis of PIK3CA, JAK2, BRAF, FOXL2, IDH1, AKT1 and EZH2 oncogenes in sarcomas.APMIS. 2012 Aug;120(8):635-9. doi: 10.1111/j.1600-0463.2012.02878.x. Epub 2012 Mar 24.
145 A novel CIC-FOXO4 gene fusion in undifferentiated small round cell sarcoma: a genetically distinct variant of Ewing-like sarcoma.Am J Surg Pathol. 2014 Nov;38(11):1571-6. doi: 10.1097/PAS.0000000000000286.
146 Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation.PLoS One. 2015 May 15;10(5):e0126562. doi: 10.1371/journal.pone.0126562. eCollection 2015.
147 Hice1, a novel microtubule-associated protein required for maintenance of spindle integrity and chromosomal stability in human cells.Mol Cell Biol. 2008 Jun;28(11):3652-62. doi: 10.1128/MCB.01923-07. Epub 2008 Mar 24.
148 hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cells.Nucleic Acids Res. 2017 Dec 1;45(21):12270-12284. doi: 10.1093/nar/gkx831.
149 YWHAE Rearrangement in a Purely Conventional Low-grade Endometrial Stromal Sarcoma that Transformed Over Time to High-grade Sarcoma: Importance of Molecular Testing.Int J Gynecol Pathol. 2018 Sep;37(5):441-447. doi: 10.1097/PGP.0000000000000451.
150 Does a less intensive surveillance protocol affect the survival of patients after treatment of a sarcoma of the limb? updated results of the randomized TOSS study.Bone Joint J. 2018 Feb;100-B(2):262-268. doi: 10.1302/0301-620X.100B2.BJJ-2017-0789.R1.
151 Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas.Clin Cancer Res. 2011 Apr 1;17(7):1828-38. doi: 10.1158/1078-0432.CCR-10-2066. Epub 2011 Feb 16.
152 Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.Cancer Lett. 2015 Dec 1;369(1):202-11. doi: 10.1016/j.canlet.2015.08.016. Epub 2015 Aug 24.
153 Retinoic acid receptor and retinoid X receptor expression in retinoic acid-resistant human tumor cell lines.Mol Carcinog. 1993;8(2):112-22. doi: 10.1002/mc.2940080208.
154 Discovery and characterization of two novel human cancer-related proteins using two-dimensional gel electrophoresis.Electrophoresis. 1994 Mar-Apr;15(3-4):345-57. doi: 10.1002/elps.1150150154.
155 LRRC15 Is a Novel Mesenchymal Protein and Stromal Target for Antibody-Drug Conjugates.Cancer Res. 2018 Jul 15;78(14):4059-4072. doi: 10.1158/0008-5472.CAN-18-0327. Epub 2018 May 15.
156 Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma.Nat Genet. 2014 Jul;46(7):666-8. doi: 10.1038/ng.2989. Epub 2014 May 25.
157 Cardiomyogenic differentiation in cardiac myxoma expressing lineage-specific transcription factors.Am J Pathol. 2002 Aug;161(2):381-9. doi: 10.1016/S0002-9440(10)64193-4.
158 Sarcoma with MGA-NUTM1 fusion in the lung: an emerging entity.Virchows Arch. 2020 Feb;476(2):317-322. doi: 10.1007/s00428-019-02623-8. Epub 2019 Aug 5.
159 High frequency of clonal immunoglobulin receptor gene rearrangements in sporadic histiocytic/dendritic cell sarcomas.Am J Surg Pathol. 2009 Jun;33(6):863-73. doi: 10.1097/PAS.0b013e31819287b8.
160 RREB1-MKL2 fusion in biphenotypic "oropharyngeal" sarcoma: New entity or part of the spectrum of biphenotypic sinonasal sarcomas?.Genes Chromosomes Cancer. 2018 Apr;57(4):203-210. doi: 10.1002/gcc.22521. Epub 2018 Jan 25.
161 MUC5AC/-catenin expression and KRAS gene alteration in laterally spreading colorectal tumors.World J Gastroenterol. 2012 Oct 21;18(39):5551-9. doi: 10.3748/wjg.v18.i39.5551.
162 Human smooth muscle myosin light chain-2 gene expression is repressed in ras transformed fibroblast cells.Cell Growth Differ. 1992 Jan;3(1):1-10.
163 Beyond "Triton": Malignant Peripheral Nerve Sheath Tumors With Complete Heterologous Rhabdomyoblastic Differentiation Mimicking Spindle Cell Rhabdomyosarcoma.Am J Surg Pathol. 2019 Oct;43(10):1323-1330. doi: 10.1097/PAS.0000000000001290.
164 Amplification and protein expression of chromosome 12q13-15 genes in osteosarcomas of the jaws.Oral Oncol. 2001 Oct;37(7):566-71. doi: 10.1016/s1368-8375(00)00130-5.
165 EGFR, KRAS, BRAF and ALK gene alterations in lung adenocarcinomas: patient outcome, interplay with morphology and immunophenotype.Eur Respir J. 2014 Mar;43(3):872-83. doi: 10.1183/09031936.00018013. Epub 2013 Aug 29.
166 EWSR1-NFATC2 Translocation-associated Sarcoma Clinicopathologic Findings in a Rare Aggressive Primary Bone or Soft Tissue Tumor.Am J Surg Pathol. 2019 Aug;43(8):1112-1122. doi: 10.1097/PAS.0000000000001260.
167 PAX7 immunohistochemical evaluation of Ewing sarcoma and other small round cell tumours.Histopathology. 2018 Oct;73(4):645-652. doi: 10.1111/his.13689. Epub 2018 Aug 2.
168 The gene expression profile of extraskeletal myxoid chondrosarcoma.J Pathol. 2005 Aug;206(4):433-44. doi: 10.1002/path.1792.
169 Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-B signaling pathway.Int J Biol Macromol. 2017 Feb;95:357-362. doi: 10.1016/j.ijbiomac.2016.10.112. Epub 2016 Nov 22.
170 Genomic organization of the OS-9 gene amplified in human sarcomas.J Biochem. 1997 Dec;122(6):1190-5. doi: 10.1093/oxfordjournals.jbchem.a021880.
171 Cloning of P2XM, a novel human P2X receptor gene regulated by p53.Cancer Res. 1997 Aug 1;57(15):3281-7.
172 Ewing sarcoma and Ewing-like tumors.Virchows Arch. 2020 Jan;476(1):109-119. doi: 10.1007/s00428-019-02720-8. Epub 2019 Dec 4.
173 The expression and function of PAX3 in development and disease.Gene. 2018 Aug 5;666:145-157. doi: 10.1016/j.gene.2018.04.087. Epub 2018 May 4.
174 Inflammatory leiomyosarcoma is a distinct tumor characterized by near-haploidization, few somatic mutations, and a primitive myogenic gene expression signature.Mod Pathol. 2018 Jan;31(1):93-100. doi: 10.1038/modpathol.2017.113. Epub 2017 Sep 8.
175 Soft tissue sarcoma and the hereditary non-polyposis colorectal cancer (HNPCC) syndrome: formulation of an hypothesis.Mol Biol Rep. 2012 Oct;39(10):9307-10. doi: 10.1007/s11033-012-1729-2. Epub 2012 Jul 11.
176 The wide spectrum of POT1 gene variants correlates with multiple cancer types.Eur J Hum Genet. 2017 Nov;25(11):1278-1281. doi: 10.1038/ejhg.2017.134. Epub 2017 Aug 30.
177 Sarcoma family kinase activity is required for cortical spreading depression.Cephalalgia. 2018 Oct;38(11):1748-1758. doi: 10.1177/0333102417748572. Epub 2017 Dec 14.
178 Impact of expression of the uPA system in sarcomas.Biomark Med. 2013 Jun;7(3):473-80. doi: 10.2217/bmm.12.105.
179 A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells.Cancer Res. 1993 Apr 1;53(7):1498-502.
180 Specific targeting of a naturally presented osteosarcoma antigen, papillomavirus binding factor peptide, using an artificial monoclonal antibody.J Biol Chem. 2014 Aug 8;289(32):22035-47. doi: 10.1074/jbc.M114.568725. Epub 2014 Jun 24.
181 Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction.Int J Mol Med. 2015 Aug;36(2):473-84. doi: 10.3892/ijmm.2015.2237. Epub 2015 Jun 5.
182 Cellular retinol-binding protein I, a regulator of breast epithelial retinoic acid receptor activity, cell differentiation, and tumorigenicity.J Natl Cancer Inst. 2005 Jan 5;97(1):21-9. doi: 10.1093/jnci/dji004.
183 IGF-1R/MDM2 relationship confers enhanced sensitivity to RITA in Ewing sarcoma cells.Mol Cancer Ther. 2012 Jun;11(6):1247-56. doi: 10.1158/1535-7163.MCT-11-0913. Epub 2012 Mar 28.
184 Reduced expression of the ROCK inhibitor Rnd3 is associated with increased invasiveness and metastatic potential in mesenchymal tumor cells.PLoS One. 2010 Nov 30;5(11):e14154. doi: 10.1371/journal.pone.0014154.
185 Does Patellar Tendon Repair With Gastrocnemius Flap Augmentation Effectively Restore Active Extension After Proximal Tibial Sarcoma Resection?.Clin Orthop Relat Res. 2019 Mar;477(3):584-593. doi: 10.1097/CORR.0000000000000564.
186 Secretogranin II expression in Ewing's sarcomas and primitive neuroectodermal tumors.Diagn Mol Pathol. 1992 Sep;1(3):165-72.
187 Functional characterization of obesity-associated variants involving the and isoforms of human SH2B1.Endocrinology. 2014 Sep;155(9):3219-26. doi: 10.1210/en.2014-1264. Epub 2014 Jun 27.
188 A two-gene signature, SKI and SLAMF1, predicts time-to-treatment in previously untreated patients with chronic lymphocytic leukemia.PLoS One. 2011;6(12):e28277. doi: 10.1371/journal.pone.0028277. Epub 2011 Dec 14.
189 When the guardian sleeps: Reactivation of the p53 pathway in cancer.Mutat Res Rev Mutat Res. 2017 Jul;773:1-13. doi: 10.1016/j.mrrev.2017.02.003. Epub 2017 Feb 17.
190 The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1).PLoS One. 2013;8(1):e49709. doi: 10.1371/journal.pone.0049709. Epub 2013 Jan 9.
191 Detection of SYT-SSX rearrangements in synovial sarcomas by real-time one-step RT-PCR.Pediatr Dev Pathol. 2005 Mar-Apr;8(2):162-7. doi: 10.1007/s10024-004-8097-4. Epub 2005 Mar 8.
192 Evaluation of expression of cancer stem cell markers and fusion gene in synovial sarcoma: Insights into histogenesis and pathogenesis.Oncol Rep. 2017 Jun;37(6):3351-3360. doi: 10.3892/or.2017.5617. Epub 2017 May 2.
193 Purification and characterization of human lung fibroblast motility-stimulating factor for human soft tissue sarcoma cells: identification as an NH2-terminal fragment of human fibronectin.Cancer Res. 1997 Aug 15;57(16):3577-84.
194 mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.Genes Chromosomes Cancer. 2011 May;50(5):338-47. doi: 10.1002/gcc.20858. Epub 2011 Feb 22.
195 Immunohistochemical correlates of recurrent genetic alterations in sarcomas.Genes Chromosomes Cancer. 2019 Feb;58(2):111-123. doi: 10.1002/gcc.22700. Epub 2018 Dec 19.
196 SMARCA4-deficient thoracic sarcoma: a distinctive clinicopathological entity with undifferentiated rhabdoid morphology and aggressive behavior.Mod Pathol. 2017 Oct;30(10):1422-1432. doi: 10.1038/modpathol.2017.61. Epub 2017 Jun 23.
197 Suppression of tubulin tyrosine ligase during tumor growth.J Cell Sci. 1998 Jan;111 ( Pt 2):171-81. doi: 10.1242/jcs.111.2.171.
198 First case of B ALL with KMT2A-MAML2 rearrangement: a case report.BMC Cancer. 2017 May 23;17(1):363. doi: 10.1186/s12885-017-3368-4.