Details of the Drug Combination

General Information of Drug Combination (ID: DC4YIKK)

Drug Combination Name
Sulindac Ruxolitinib
Indication
Disease Entry Status REF
Hodgkin lymphoma Investigative [1]
Component Drugs Sulindac   DM2QHZU Ruxolitinib   DM7Q98D
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: L-1236
Zero Interaction Potency (ZIP) Score: 17.469
Bliss Independence Score: 22.472
Loewe Additivity Score: 3.231
LHighest Single Agent (HSA) Score: 11.885

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Sulindac
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [2]
Bursitis N.A. Approved [2]
Osteoarthritis FA00-FA05 Approved [2]
Rheumatoid arthritis FA20 Approved [3]
Colon cancer 2B90.Z Investigative [2]
Sulindac Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aldose reductase (AKR1B1) TTFBNVI ALDR_HUMAN Inhibitor [14]
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Sulindac Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [15]
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Sulindac Interacts with 201 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15) OT0RTR7M LOX15_HUMAN Increases Activity [16]
Arylamine N-acetyltransferase 1 (NAT1) OTCCNQ3H ARY1_HUMAN Decreases Expression [17]
Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3) OTBQRU82 GAL3B_HUMAN Decreases Expression [10]
Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (ELAPOR2) OTL628I1 ELAP2_HUMAN Increases Expression [10]
Protocadherin-17 (PCDH17) OTRK0M05 PCD17_HUMAN Decreases Expression [10]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [10]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Decreases Expression [10]
NPC intracellular cholesterol transporter 1 (NPC1) OTRIPICX NPC1_HUMAN Increases Expression [10]
T-box transcription factor TBX3 (TBX3) OTM64N7K TBX3_HUMAN Increases Expression [10]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [10]
Monocarboxylate transporter 7 (SLC16A6) OT7BIIZX MOT7_HUMAN Increases Expression [10]
Origin recognition complex subunit 4 (ORC4) OT3ACTST ORC4_HUMAN Decreases Expression [10]
Bromodomain-containing protein 4 (BRD4) OT2Y2TCW BRD4_HUMAN Decreases Expression [10]
Transmembrane protein 127 (TMEM127) OTYHUXC1 TM127_HUMAN Increases Expression [10]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [10]
Stanniocalcin-2 (STC2) OT86YP8G STC2_HUMAN Increases Expression [10]
Ribonuclease pancreatic (RNASE1) OTKZ7CO9 RNAS1_HUMAN Decreases Expression [10]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [10]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Increases Expression [10]
Calmodulin-1 (CALM2) OTNYA92F CALM1_HUMAN Decreases Expression [10]
Lysosomal acid phosphatase (ACP2) OTLPA1LJ PPAL_HUMAN Increases Expression [10]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2) OT1LQSGX MTDC_HUMAN Increases Expression [10]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [10]
Protein C-ets-1 (ETS1) OT4LVGDN ETS1_HUMAN Increases Expression [10]
Integrin alpha-2 (ITGA2) OTPFL017 ITA2_HUMAN Increases Expression [10]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [10]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [10]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [10]
Casein kinase II subunit alpha' (CSNK2A2) OT7MA2LV CSK22_HUMAN Increases Expression [10]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [10]
DNA excision repair protein ERCC-5 (ERCC5) OTQAKFJM ERCC5_HUMAN Decreases Expression [10]
High affinity cationic amino acid transporter 1 (SLC7A1) OTR2ZVA8 CTR1_HUMAN Increases Expression [10]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Expression [10]
Biotin--protein ligase (HLCS) OTPDUX30 BPL1_HUMAN Decreases Expression [10]
Plexin-A3 (PLXNA3) OTMZIBVG PLXA3_HUMAN Increases Expression [10]
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 (NDST2) OT21PY3J NDST2_HUMAN Decreases Expression [10]
Small ubiquitin-related modifier 3 (SUMO3) OTTUJQJ1 SUMO3_HUMAN Decreases Expression [10]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Increases Expression [10]
Casein kinase II subunit alpha (CSNK2A1) OT9T8WQM CSK21_HUMAN Decreases Expression [10]
Polycystin-1 (PKD1) OT5ALRZ5 PKD1_HUMAN Increases Expression [10]
Transcription initiation factor IIB (GTF2B) OTAH5NSO TF2B_HUMAN Increases Expression [10]
Cyclin-dependent kinase 3 (CDK3) OT2GP6RL CDK3_HUMAN Decreases Expression [10]
Cdc42 effector protein 1 (CDC42EP1) OTT525WA BORG5_HUMAN Increases Expression [10]
Growth factor receptor-bound protein 10 (GRB10) OTCKXGRC GRB10_HUMAN Increases Expression [10]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [10]
Krueppel-like factor 5 (KLF5) OT1ABI9N KLF5_HUMAN Increases Expression [10]
Dihydropyrimidinase (DPYS) OTLTUIVL DPYS_HUMAN Increases Expression [10]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Increases Expression [10]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1) OT1QHOS2 NF2L1_HUMAN Increases Expression [10]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Increases Expression [10]
Syntaxin-binding protein 2 (STXBP2) OTX8GUC4 STXB2_HUMAN Increases Expression [10]
Nuclear factor interleukin-3-regulated protein (NFIL3) OTQH9HM3 NFIL3_HUMAN Increases Expression [10]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2) OTJ8LX4N PCKGM_HUMAN Increases Expression [10]
TBC1 domain family member 10B (TBC1D10B) OT5MVCI5 TB10B_HUMAN Increases Expression [10]
Migration and invasion-inhibitory protein (MIIP) OT79EXZ7 MIIP_HUMAN Increases Expression [10]
Cyclin-J (CCNJ) OTCR4WVV CCNJ_HUMAN Decreases Expression [10]
OTU domain-containing protein 1 (OTUD1) OTE6O5XB OTUD1_HUMAN Increases Expression [10]
Tensin-3 (TNS3) OTPG2D8Z TENS3_HUMAN Decreases Expression [10]
F-box only protein 42 (FBXO42) OTHPN53C FBX42_HUMAN Increases Expression [10]
Metal transporter CNNM4 (CNNM4) OTUXJRM1 CNNM4_HUMAN Increases Expression [10]
Ankyrin repeat domain-containing protein 11 (ANKRD11) OTV0V70M ANR11_HUMAN Increases Expression [10]
La-related protein 4 (LARP4) OTB10IJH LARP4_HUMAN Increases Expression [10]
LIM domain-binding protein 1 (LDB1) OT20EAPR LDB1_HUMAN Increases Expression [10]
Transmembrane protein adipocyte-associated 1 (TPRA1) OTL61503 TPRA1_HUMAN Increases Expression [10]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Increases Expression [10]
UPF0690 protein C1orf52 (C1ORF52) OT8RQW3W CA052_HUMAN Increases Expression [10]
Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (LFNG) OTPSUBN2 LFNG_HUMAN Increases Expression [10]
Osteoclast-stimulating factor 1 (OSTF1) OT8D7CDO OSTF1_HUMAN Increases Expression [10]
Caveolae-associated protein 3 (CAVIN3) OTOLBK79 CAVN3_HUMAN Increases Expression [10]
Sorting nexin-21 (SNX21) OT8O6909 SNX21_HUMAN Increases Expression [10]
Arrestin domain-containing protein 3 (ARRDC3) OTAKW7R9 ARRD3_HUMAN Increases Expression [10]
Splicing factor ESS-2 homolog (ESS2) OTZ08VCZ ESS2_HUMAN Increases Expression [10]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Increases Expression [10]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Decreases Expression [10]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [10]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) OTALABSK S38A2_HUMAN Increases Expression [10]
Mediator of RNA polymerase II transcription subunit 15 (MED15) OT0D0JVD MED15_HUMAN Increases Expression [10]
Pleckstrin homology domain-containing family F member 1 (PLEKHF1) OT9OL16U PKHF1_HUMAN Increases Expression [10]
Sialidase-1 (NEU1) OTH9BY8Y NEUR1_HUMAN Increases Expression [10]
Translin-associated protein X (TSNAX) OTZ9SGWB TSNAX_HUMAN Decreases Expression [10]
Copine-1 (CPNE1) OTH5YKSL CPNE1_HUMAN Decreases Expression [10]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [10]
Allograft inflammatory factor 1-like (AIF1L) OTDEOB80 AIF1L_HUMAN Decreases Expression [10]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [10]
Transmembrane emp24 domain-containing protein 9 (TMED9) OTYGAQS0 TMED9_HUMAN Decreases Expression [10]
E3 ubiquitin-protein ligase RNF26 (RNF26) OTPXA60S RNF26_HUMAN Decreases Expression [10]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Increases Expression [10]
Sorting nexin-25 (SNX25) OT8JY8M1 SNX25_HUMAN Increases Expression [10]
tRNA dimethylallyltransferase (TRIT1) OTCU9FS5 MOD5_HUMAN Decreases Expression [10]
PDZ and LIM domain protein 7 (PDLIM7) OTAZVODU PDLI7_HUMAN Increases Expression [10]
Phosphatidylinositol polyphosphate 5-phosphatase type IV (INPP5E) OTJF2AZ9 INP5E_HUMAN Increases Expression [10]
Transmembrane protein 39A (TMEM39A) OTRT51D9 TM39A_HUMAN Increases Expression [10]
Arginine and glutamate-rich protein 1 (ARGLU1) OTRVRZ4Z ARGL1_HUMAN Increases Expression [10]
SUN domain-containing protein 2 (SUN2) OT2IQJUC SUN2_HUMAN Decreases Expression [10]
B-cell receptor-associated protein 29 (BCAP29) OTLUBG86 BAP29_HUMAN Increases Expression [10]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Increases Expression [10]
Solute carrier family 22 member 2 (SLC22A2) OTGFK1AL S22A2_HUMAN Decreases Activity [18]
Solute carrier family 22 member 1 (SLC22A1) OT7817I4 S22A1_HUMAN Decreases Activity [18]
Solute carrier family 22 member 6 (SLC22A6) OTKRCBVM S22A6_HUMAN Decreases Activity [18]
Organic anion transporter 7 (SLC22A9) OTO4BJCC S22A9_HUMAN Decreases Activity [18]
Solute carrier family 22 member 11 (SLC22A11) OTAJLNJZ S22AB_HUMAN Decreases Activity [18]
Solute carrier family 22 member 7 (SLC22A7) OTKTNH1W S22A7_HUMAN Decreases Activity [18]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [19]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [20]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Decreases Activity [21]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [11]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Expression [11]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Increases Localization [11]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [11]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Decreases Activity [22]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Decreases Activity [22]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Decreases Activity [22]
Ladinin-1 (LAD1) OT6YGTVX LAD1_HUMAN Increases Expression [23]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [24]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Activity [25]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Increases Expression [26]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [27]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Increases Expression [28]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Affects Localization [29]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [29]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Activity [30]
Metalloproteinase inhibitor 1 (TIMP1) OTOXC51H TIMP1_HUMAN Affects Expression [31]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [32]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Increases Expression [33]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [34]
HLA class I histocompatibility antigen, B alpha chain (HLA-B) OTNXFWY2 HLAB_HUMAN Affects Expression [35]
Apolipoprotein C-III (APOC3) OTW3520C APOC3_HUMAN Decreases Secretion [28]
Ferritin heavy chain (FTH1) OT6IFS0O FRIH_HUMAN Increases Expression [12]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Secretion [28]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [36]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [37]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Decreases Expression [38]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [39]
Protein disulfide-isomerase (P4HB) OTTYNYPF PDIA1_HUMAN Decreases Expression [28]
Decorin (DCN) OTWLJL7K PGS2_HUMAN Decreases Expression [23]
Proto-oncogene tyrosine-protein kinase receptor Ret (RET) OTLU040A RET_HUMAN Affects Expression [31]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Decreases Expression [40]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Activity [36]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Affects Expression [31]
Cyclin-dependent kinase 4 (CDK4) OT7EP05T CDK4_HUMAN Decreases Expression [41]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [12]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Decreases Activity [42]
Neuromodulin (GAP43) OT2OTGGV NEUM_HUMAN Affects Expression [31]
Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6) OTAFHAVI ATF6A_HUMAN Increases Expression [28]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Activity [43]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [38]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Affects Expression [31]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [44]
G1/S-specific cyclin-E1 (CCNE1) OTLD7UID CCNE1_HUMAN Decreases Expression [38]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Activity [45]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Phosphorylation [46]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [40]
Protein-lysine 6-oxidase (LOX) OT1C2HIU LYOX_HUMAN Decreases Expression [47]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [40]
Protein PML (PML) OT6SM2GD PML_HUMAN Increases Expression [39]
Leukocyte elastase inhibitor (SERPINB1) OT5RDUFO ILEU_HUMAN Increases Expression [23]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [47]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Increases Expression [27]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [48]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Decreases Expression [44]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [49]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [39]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [23]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Expression [50]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [51]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Increases Expression [27]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [28]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Decreases Phosphorylation [42]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Increases Response To Substance [52]
ATP-citrate synthase (ACLY) OTRL9ZRP ACLY_HUMAN Increases Expression [28]
Microsomal triglyceride transfer protein large subunit (MTTP) OTNUVSDT MTP_HUMAN Increases Expression [28]
Nucleosome assembly protein 1-like 1 (NAP1L1) OTI7WBZV NP1L1_HUMAN Decreases Expression [23]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [36]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Decreases Expression [38]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Activity [34]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Decreases Expression [38]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1) OTF6OC66 GCNT1_HUMAN Increases Expression [12]
Cytochrome P450 4A11 (CYP4A11) OTPU5J0S CP4AB_HUMAN Affects Activity [53]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Expression [54]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [39]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [55]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [36]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Expression [28]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Decreases Activity [42]
Endonuclease G, mitochondrial (ENDOG) OT5IM7B3 NUCG_HUMAN Affects Localization [29]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) OT9EROL6 HERP1_HUMAN Increases Expression [12]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Affects Localization [56]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Decreases Expression [47]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [47]
Dehydrogenase/reductase SDR family member 11 (DHRS11) OTU3J0ZL DHR11_HUMAN Decreases Activity [57]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [39]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Decreases Expression [58]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [26]
Transmembrane 7 superfamily member 3 (TM7SF3) OTT9RKL6 TM7S3_HUMAN Decreases Expression [12]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Expression [28]
Serine/threonine-protein kinase TBK1 (TBK1) OT1P06NV TBK1_HUMAN Increases Expression [12]
Angiopoietin-related protein 3 (ANGPTL3) OTCD5Z9W ANGL3_HUMAN Decreases Expression [28]
eIF5-mimic protein 1 (BZW2) OTBT0A1B 5MP1_HUMAN Decreases Expression [12]
Flavin-containing monooxygenase 3 (FMO3) OT1G2EV3 FMO3_HUMAN Increases Metabolism [59]
GTPase KRas (KRAS) OT78QCN8 RASK_HUMAN Affects Response To Substance [60]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Response To Substance [55]
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⏷ Show the Full List of 201 DOT(s)
Indication(s) of Ruxolitinib
Disease Entry ICD 11 Status REF
Essential thrombocythemia 3B63.1Z Approved [4]
High-risk myelofibrosis 2A20.2 Approved [5]
Myelofibrosis 2A22 Approved [6]
Myeloproliferative neoplasm 2A20 Approved [7]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [8]
Pancreatic cancer 2C10 Phase 3 [5]
Atopic dermatitis EA80 Phase 1/2 [9]
Vitiligo ED63.0 Phase 1/2 [9]
Ruxolitinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Modulator [61]
Janus kinase 1 (JAK-1) TT6DM01 JAK1_HUMAN Modulator [61]
Urokinase plasminogen activator surface receptor (PLAUR) TTPRL03 UPAR_HUMAN Inhibitor [62]
HUMAN janus kinase 1 (JAK-1) TTWKB01 JAK1_HUMAN Inhibitor [63]
HUMAN janus kinase 2 (JAK-2) TT0F5HE JAK2_HUMAN Inhibitor [63]
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Ruxolitinib Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases ADR [64]
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References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Sulindac FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5425).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5688).
6 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
7 Ruxolitinib FDA Label
8 Incyte begins Phase III trial of ruxolitinib to treat Covid-19. 20.April.2020.
9 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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