Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM43AN2)

• Drug Name: Fructose Drug Info
• Synonyms: D-(-)-Fructose; 57-48-7; D(-)-Fructose; (3S,4R,5R)-1,3,4,5,6-pentahydroxyhexan-2-one; 53188-23-1; D-(-)-Levulose; D-Levulose; Nevulose; Furucton; arabino-Hexulose; Sugar, fruit; Fructose, D-; Krystar 300; Hi-Fructo 970; keto-D-fructose; Fructose, pure; Fructose solution; CCRIS 3335; 30237-26-4; EINECS 200-333-3; AI3-23514; DL-Fructose; MFCD00148910; D(-)-Fructose, 99%; Fructon; D-(-)-Fructose, > Methose; Levulosa; Levulosa Baxter; Levulosa Braun; Apir Levulosa; Levulosa Mein; Levulosa Ibys; Levulosa Ife; Levulosado Braun; D-fructose

Indication

Disease Entry	ICD 11	Status	REF
Vomiting	MD90	Approved	[1]

• Cross-matching ID:
  PubChem CID: 2723872
  ChEBI ID: CHEBI:37714
  CAS Number: CAS 6347-01-9
  TTD Drug ID: DM43AN2
  VARIDT Drug ID: DR00043
  INTEDE Drug ID: DR1932

Molecule-Related Drug Atlas

Drug(s) Targeting Fragile histidine triad protein (FHIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine Monotungstate	DMJZPSX	Discovery agent	N.A.	Investigative	[2]
Ado-P-Ch2-P-Ps-Ado	DM9IBHU	Discovery agent	N.A.	Investigative	[2]

Drug(s) Transported By Glucose transporter type 7 (SLC2A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[5]

Drug(s) Transported By Sodium/glucose cotransporter 4 (SLC5A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[3]
D-mannose	DMT6X03	Discovery agent	N.A.	Investigative	[3]

Drug(s) Metabolized By Sorbitol dehydrogenase (SORD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[11]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[14]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[17]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[18]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[19]
Methamphetamine	DMPM4SK	Anxiety		Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 7 (SLC2A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[24]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[25]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[26]
Ketoprofen	DMRKXPT	Bursitis		Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[28]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[34]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[38]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[39]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[41]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[45]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[60]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[61]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[62]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[63]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[64]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[64]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[65]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[66]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[69]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[70]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[71]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[73]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[80]

Drug(s) Affected By Acetyl-CoA carboxylase 2 (ACACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[87]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[90]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[91]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[92]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[12]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Haloperidol	DM96SE0	Delirium		Approved	[27]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[98]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[100]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[110]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[111]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[39]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[119]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[122]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]

Drug(s) Affected By Calcitonin (CALCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[87]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[125]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[128]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[129]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[136]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[137]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[136]

Drug(s) Affected By Platelet factor 4 (PF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[142]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[147]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[149]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[150]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[150]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[150]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[150]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[46]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[158]

Drug(s) Affected By Apolipoprotein A-IV (APOA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[129]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[162]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[164]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[167]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[169]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[113]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[175]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[176]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[177]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[178]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[179]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[182]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[27]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[184]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[185]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[29]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[186]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[190]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[191]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[192]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[195]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[201]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[195]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 4 (SLC2A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[107]
Haloperidol	DM96SE0	Delirium		Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[206]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[19]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[209]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[212]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[213]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[126]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[217]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[88]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[219]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[227]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[228]

Drug(s) Affected By Type-1 angiotensin II receptor (AGTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]

Drug(s) Affected By Hepatocyte nuclear factor 4-alpha (HNF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
SR141716A	DMCO5JZ	Obesity	5B81	Approved	[238]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[240]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[241]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[242]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[245]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[246]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[247]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[249]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[250]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[251]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[45]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[256]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[257]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[258]

Drug(s) Affected By Fractalkine (CX3CL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[260]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[261]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[262]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[203]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[264]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[265]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[266]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[204]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[267]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[270]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[84]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[129]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[22]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[273]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 11 (SLC2A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[274]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[204]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[275]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[275]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[275]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[23]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[276]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fragile histidine triad protein (FHIT)	TTMS54D	FHIT_HUMAN	Inhibitor	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium/glucose cotransporter 4 (SLC5A9)	DT1CP40	SC5A9_HUMAN	Substrate	[3]
Glucose transporter type 5, small intestine (SLC2A5)	DTOR02F	GTR5_HUMAN	Substrate	[4]
Glucose transporter type 7 (SLC2A7)	DT8SQBG	GTR7_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sorbitol dehydrogenase (SORD) Main DME	DEWU03P	DHSO_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acetyl-CoA carboxylase 2 (ACACB)	OT96UIP1	ACACB_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein A-IV (APOA4)	OT466POQ	APOA4_HUMAN	Gene/Protein Processing	[8]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[9]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[9]
Calcitonin (CALCA)	OTZ11LHB	CALC_HUMAN	Gene/Protein Processing	[9]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[9]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Gene/Protein Processing	[9]
Fractalkine (CX3CL1)	OTPLGI0E	X3CL1_HUMAN	Gene/Protein Processing	[9]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Gene/Protein Processing	[9]
Hepatocyte nuclear factor 4-alpha (HNF4A)	OTY1TOAB	HNF4A_HUMAN	Gene/Protein Processing	[10]

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