Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM7HXWT)

Drug Name
Nilotinib Drug Info
Synonyms
NIL; Nilotinibum; Tasigna (Novartis); Nilotinib (INN/USAN); Nilotinib, AMN107, Tasigna; Tasigna, AMN-107, Nilotinib; L-1-yl)-3-(trifluoromethyl)phenyl]benzamide; Benzamide, 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-(9CI); 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazo; 4-Methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide; 4-Methyl-N-[3-(4-methylimidazol-1-yl)-5-trifluoromethylphenyl]-3-[[4-(pyridin-3-yl)pyrimidin-2-yl]amino]benzamide; 4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]benzamide; Nilotinib (BCR-ABL inhibitor 2nd gen)
Indication
Disease Entry ICD 11 Status REF
Chronic myelogenous leukaemia 2A20.0 Approved [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
644241
ChEBI ID
CHEBI:52172
CAS Number
CAS 641571-10-0
TTD Drug ID
DM7HXWT
VARIDT Drug ID
DR00013
INTEDE Drug ID
DR1155
ACDINA Drug ID
D00468

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Fusion protein Bcr-Abl (Bcr-Abl)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [15]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [15]
Asciminib DM7EVUF Chronic myeloid leukaemia 2A20 Approved [16]
Radotinib DMWA74Y leukaemia 2A60-2B33 Phase 3 [17]
ABL 001 DMMF5K4 Chronic myeloid leukaemia 2A20 Phase 3 [18]
ICLUSIG DM1SQSE Acute lymphoblastic leukaemia 2A85 Phase 3 [19]
Bafetinib DM7586F Bone disease FC0Z Phase 2 [20]
AN-019 DMJ7QP8 Chronic myelogenous leukaemia 2A20.0 Phase 2 [21]
HQP1351 DMQ30X2 Chronic myeloid leukaemia 2A20 Phase 2 [22]
NPB-001-056 DM78KMT Chronic myelogenous leukaemia 2A20.0 Phase 1/2 [23]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [25]
Folic Acid DMEMBJC Colorectal carcinoma Approved [26]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [30]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [31]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [33]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [34]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Folic Acid DMEMBJC Colorectal carcinoma Approved [37]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [36]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [38]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [36]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [39]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [40]
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Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Folic Acid DMEMBJC Colorectal carcinoma Approved [43]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [44]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [45]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [46]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [47]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [46]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [48]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [49]
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Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [50]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [51]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [4]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [4]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [53]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [54]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [55]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [56]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [53]
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Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [57]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [4]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [58]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [59]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [4]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [60]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [54]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [56]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [61]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [56]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [63]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [64]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [65]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [66]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [67]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [68]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [69]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [63]
Verapamil DMA7PEW Angina pectoris BA40 Approved [70]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [71]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [7]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [7]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [72]
Verapamil DMA7PEW Angina pectoris BA40 Approved [73]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [74]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [75]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [7]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [76]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [77]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [78]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [78]
Gefitinib DM15F0X Colon adenocarcinoma Approved [79]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [80]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [83]
Quercetin DM3NC4M Obesity 5B81 Approved [84]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [85]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [86]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [87]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [88]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [89]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [90]
Cepharanthine DM9Y5JB N. A. N. A. Approved [91]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [92]
Clozapine DMFC71L Schizophrenia 6A20 Approved [93]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [94]
Trifluoperazine DMKBYWI Anxiety Approved [95]
Olanzapine DMPFN6Y Bipolar depression Approved [93]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [97]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [98]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [99]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [100]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [101]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [103]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [104]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [105]
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Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [106]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [109]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [110]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [112]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [113]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [114]
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Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [115]
Quinidine DMLPICK N. A. N. A. Approved [116]
Verapamil DMA7PEW Angina pectoris BA40 Approved [117]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [118]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [118]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [119]
Propranolol DM79NTF Angina pectoris BA40 Approved [120]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [121]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [122]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [118]
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Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [123]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [124]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [8]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [129]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [130]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [131]
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Drug(s) Affected By Retinal dehydrogenase 2 (ALDH1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [133]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [134]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Metoclopramide DMFA5MY Nausea MD90 Approved [132]
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Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [80]
Anagrelide DMSQ8MD Thrombocythemia 3B63 Approved [80]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Testosterone DM7HUNW Hot flushes GA30 Approved [139]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [140]
Capsaicin DMGMF6V Back pain ME84.Z Approved [141]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [142]
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Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Verapamil DMA7PEW Angina pectoris BA40 Approved [144]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [144]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [145]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [146]
Methotrexate DM2TEOL Anterior urethra cancer Approved [147]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [148]
Quercetin DM3NC4M Obesity 5B81 Approved [149]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [99]
Paclitaxel DMLB81S Breast carcinoma Approved [154]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [159]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [160]
Fructose DM43AN2 Vomiting MD90 Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [162]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [166]
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Drug(s) Affected By Homeobox protein Hox-B7 (HOXB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Testosterone enanthate DMB6871 N. A. N. A. Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [169]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [170]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [171]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Gefitinib DM15F0X Colon adenocarcinoma Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [175]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [176]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [177]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [176]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [178]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [179]
Methotrexate DM2TEOL Anterior urethra cancer Approved [180]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [181]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [182]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [184]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [80]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Verapamil DMA7PEW Angina pectoris BA40 Approved [185]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [186]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [187]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [188]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [189]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [190]
Etretinate DM2CZFA Keratosis ED56 Approved [191]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [192]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [193]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [194]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [195]
Quercetin DM3NC4M Obesity 5B81 Approved [196]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [197]
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Drug(s) Affected By Breakpoint cluster region protein (BCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [169]
Folic Acid DMEMBJC Colorectal carcinoma Approved [201]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [142]
Bortezomib DMNO38U Leukemia Approved [202]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [203]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [204]
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Drug(s) Affected By Transcription factor JunB (JUNB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [162]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [205]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Quercetin DM3NC4M Obesity 5B81 Approved [196]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [138]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [207]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [208]
Leflunomide DMR8ONJ Arthritis FA20 Approved [209]
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Drug(s) Affected By Homeobox protein Hox-B9 (HOXB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [206]
Methotrexate DM2TEOL Anterior urethra cancer Approved [210]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [211]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [212]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [213]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [214]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [215]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [216]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [217]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histidine decarboxylase (HDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [219]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [220]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [221]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [222]
Isoflurophate DMBSK7X Glaucoma/ocular hypertension 9C61 Approved [223]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [133]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [223]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [224]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-3 (PAX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [133]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [227]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Folic Acid DMEMBJC Colorectal carcinoma Approved [201]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [228]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alanine aminotransferase 1 (GPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [80]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [230]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [231]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [80]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [80]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [80]
Gefitinib DM15F0X Colon adenocarcinoma Approved [9]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [232]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [9]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-6 (PAX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [167]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [133]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [233]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [212]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Folic Acid DMEMBJC Colorectal carcinoma Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [236]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [107]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [237]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [238]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [192]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [239]
Methotrexate DM2TEOL Anterior urethra cancer Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Crk-like protein (CRKL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [241]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [242]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [243]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [244]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [245]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [246]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [247]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [248]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [249]
PMID25656651-Compound-5 DMAI95U Chronic myeloid leukaemia 2A20 Patented [250]
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Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [251]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [130]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [254]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [255]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [256]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [258]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [133]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [259]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [207]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [260]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [261]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [186]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [262]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [263]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [175]
Meloxicam DM2AR7L Arthritis FA20 Approved [264]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [265]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mesoderm posterior protein 2 (MESP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [132]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [225]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Transcription factor 15 (TCF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [132]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oligodendrocyte transcription factor 3 (OLIG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [228]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Ethanol DMDRQZU Chronic pain MG30 Approved [267]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [268]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [212]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [169]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [269]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [203]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [140]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [270]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [225]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eyes absent homolog 1 (EYA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [272]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein C2 (FOXC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [132]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Panobinostat DM58WKG Chronic graft versus host disease Approved [133]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenin-2 (NEUROG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [132]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [132]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [132]
Leflunomide DMR8ONJ Arthritis FA20 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [135]
Dabigatran DMDI6R4 Stroke 8B20 Approved [132]
Folic Acid DMEMBJC Colorectal carcinoma Approved [228]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [132]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [132]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Fusion protein Bcr-Abl (Bcr-Abl) TTS7G69 BCR_HUMAN-ABL1_HUMAN Modulator [2]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [3]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [3]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [4]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [4]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [7]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Post-Translational Modifications [8]
Alanine aminotransferase 1 (GPT) OTOXOA0Q ALAT1_HUMAN Protein Interaction/Cellular Processes [9]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [10]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [11]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Post-Translational Modifications [12]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Drug Response [13]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [8]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Gene/Protein Processing [8]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [10]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Protein Interaction/Cellular Processes [14]

References

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3 Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64.
4 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
5 KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 2017 Jan 4;45(D1):D353-D361. (dg:DG01665)
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7 Role of cytochrome P450 2C8 in drug metabolism and interactions. Pharmacol Rev. 2016 Jan;68(1):168-241.
8 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
9 Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes. Toxicol Lett. 2018 Jul;291:138-148. doi: 10.1016/j.toxlet.2018.04.010. Epub 2018 Apr 12.
10 Nilotinib reduced the viability of human ovarian cancer cells via mitochondria-dependent apoptosis, independent of JNK activation. Toxicol In Vitro. 2016 Mar;31:1-11. doi: 10.1016/j.tiv.2015.11.002. Epub 2015 Nov 6.
11 Reversal of ABCB1 mediated efflux by imatinib and nilotinib in cells expressing various transporter levels. Chem Biol Interact. 2017 Aug 1;273:171-179. doi: 10.1016/j.cbi.2017.06.012. Epub 2017 Jun 13.
12 AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
13 Resistance to daunorubicin, imatinib, or nilotinib depends on expression levels of ABCB1 and ABCG2 in human leukemia cells. Chem Biol Interact. 2014 Aug 5;219:203-10. doi: 10.1016/j.cbi.2014.06.009. Epub 2014 Jun 19.
14 p53 Gene (NY-CO-13) Levels in Patients with Chronic Myeloid Leukemia: The Role of Imatinib and Nilotinib. Diseases. 2018 Jan 25;6(1):13. doi: 10.3390/diseases6010013.
15 A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
16 Asciminib in Chronic Myeloid Leukemia after ABL Kinase Inhibitor Failure. N Engl J Med. 2019 Dec 12;381(24):2315-2326.
17 Danusertib, an aurora kinase inhibitor.Expert Opin Investig Drugs.2012 Mar;21(3):383-93.
18 ABL001, a Potent Allosteric Inhibitor of BCR-ABL, Prevents Emergence of Resistant Disease When Administered in Combination with Nilotinib in an in Vivo Murine Model of Chronic Myeloid Leukemia, NorthBuilding, 2014, 120-125.
19 Ponatinib efficacy and safety in Philadelphia chromosome-positive leukemia: final 5-year results of the phase 2 PACE trial. Blood. 2018 Jul 26;132(4):393-404.
20 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
21 Design, synthesis and preclinical evaluation of NRC-AN-019. Int J Oncol. 2013 Jan;42(1):168-78.
22 Preclinical development of HQP1351, a multikinase inhibitor targeting a broad spectrum of mutant KIT kinases, for the treatment of imatinib-resistant gastrointestinal stromal tumors. Cell Biosci. 2019 Oct 26;9:88.
23 NPB001-05 inhibits Bcr-Abl kinase leading to apoptosis of imatinib-resistant cells. Front Biosci (Elite Ed). 2011 Jun 1;3:1273-88.
24 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
25 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
26 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
27 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
28 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
29 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
30 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
31 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
32 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
33 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
34 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
35 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
36 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
37 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
38 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
39 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
40 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
41 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
42 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
43 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
44 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
45 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
46 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
47 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
48 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
49 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
50 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
51 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
52 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
53 The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
54 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
55 Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52.
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