Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMA1MKT)

• Drug Name: uric acid Drug Info
• Synonyms: urate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1175
  ChEBI ID: CHEBI:17775
  CAS Number: CAS 69-93-2
  TTD Drug ID: DMA1MKT
  VARIDT Drug ID: DR00172

Molecule-Related Drug Atlas

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[16]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[19]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[22]

Drug(s) Transported By Organic anion transporter 1 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[23]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[24]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[26]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[26]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[27]
Olmesartan medoxomil	DMWBHRY	High blood pressure	BA00	Approved	[28]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[29]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[30]

Drug(s) Transported By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[32]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[33]
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[34]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[35]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[36]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[37]
Cilostazol	DMZMSCT	Intermittent claudication	BD40.00	Approved	[38]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[51]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[32]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[52]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[52]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[53]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[53]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[54]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[42]

Drug(s) Transported By Organic anion transporter 4 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[39]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[25]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[40]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[41]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[42]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[43]
Estrone sulfate	DMVBIZL	Atrophic vaginitis	GA30.2	Approved	[44]
Levocetirizine	DMQYLGP	Allergic rhinitis	CA08.0	Approved	[45]
PGF2alpha	DM4XAU7	Solid tumour/cancer	2A00-2F9Z	Clinical trial	[25]

Drug(s) Transported By Urate anion exchanger 1 (SLC22A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oxypurinol	DMURH4X	Heart failure	BD10-BD13	Phase 2/3	[46]
Orotate	DMMB29S	Discovery agent	N.A.	Investigative	[47]

Drug(s) Transported By Monocarboxylate transporter 9 (SLC16A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[48]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[57]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[55]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[55]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Haloperidol	DM96SE0	Delirium		Approved	[60]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[61]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[64]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[66]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[70]

Drug(s) Affected By Mothers against decapentaplegic homolog 7 (SMAD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[86]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[89]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[91]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[93]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[94]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[95]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[60]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[99]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[100]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[101]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[107]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[110]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[111]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[118]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[120]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[99]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[125]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[131]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[132]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[141]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[104]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[108]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[150]

Drug(s) Affected By Tyrosine-protein kinase SYK (SYK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[156]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[157]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[152]

Drug(s) Affected By Ketohexokinase (KHK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[160]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[161]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[162]

Drug(s) Affected By Sorbitol dehydrogenase (SORD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[164]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[166]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[60]

Drug(s) Affected By cGMP-dependent protein kinase 2 (PRKG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[173]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[174]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[175]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[160]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[161]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[182]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]

Drug(s) Affected By Alpha-protein kinase 1 (ALPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[160]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[186]
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[9]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[187]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[152]

Drug(s) Affected By Transcription factor Maf (MAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[189]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[190]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[191]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[192]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[88]

Drug(s) Affected By Inhibin beta B chain (INHBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Ataxin-2 (ATXN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[197]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[160]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[161]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[198]

Drug(s) Affected By Aldehyde dehydrogenase family 16 member A1 (ALDH16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[199]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[201]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[205]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[206]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[209]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[210]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[203]

Drug(s) Affected By Tyrosine-protein kinase BAZ1B (BAZ1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[211]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[211]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[213]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[198]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[198]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 9 (SLC2A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Fructose	DM43AN2	Vomiting	MD90	Approved	[217]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[161]

Drug(s) Affected By Tripartite motif-containing protein 46 (TRIM46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[218]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[221]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[160]

Drug(s) Affected By APOBEC1 complementation factor (A1CF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[225]

Drug(s) Affected By Transmembrane protein 171 (TMEM171)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[220]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[199]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[228]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[229]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[230]

Drug(s) Affected By Scm-like with four MBT domains protein 1 (SFMBT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[198]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[198]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]

Drug(s) Affected By Sodium-dependent phosphate transport protein 4 (SLC17A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[232]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[233]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]
[3H]estrone-3-sulphate	DMGPF0N	Discovery agent	N.A.	Investigative	[233]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[236]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[242]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[165]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[244]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4 (B3GNT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[245]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By Hepatic leukemia factor (HLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[229]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Hepatocyte nuclear factor 4-gamma (HNF4G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[142]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[177]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[196]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[229]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[249]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[250]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[251]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[74]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Monocarboxylate transporter 9 (SLC16A9)	DTQK5O9	MOT9_HUMAN	Substrate	[2]
Urate anion exchanger 1 (SLC22A12)	DT2WLAD	S22AC_HUMAN	Substrate	[3]
Organic anion transporter 4 (SLC22A11)	DT06JWZ	S22AB_HUMAN	Substrate	[4]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[5]
Organic anion transporter 1 (SLC22A6)	DTQ23VB	S22A6_HUMAN	Substrate	[4]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)	OTHTAM54	AAKG2_HUMAN	Regulation of Drug Effects	[6]
Aldehyde dehydrogenase family 16 member A1 (ALDH16A1)	OT50NI6Z	A16A1_HUMAN	Regulation of Drug Effects	[7]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Gene/Protein Processing	[8]
Alpha-protein kinase 1 (ALPK1)	OTBW6SGD	ALPK1_HUMAN	Gene/Protein Processing	[9]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Gene/Protein Processing	[10]
APOBEC1 complementation factor (A1CF)	OTJBKFA1	A1CF_HUMAN	Regulation of Drug Effects	[6]
Ataxin-2 (ATXN2)	OT465IGT	ATX2_HUMAN	Regulation of Drug Effects	[6]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[11]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Protein Interaction/Cellular Processes	[12]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Protein Interaction/Cellular Processes	[13]

References

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• [2] Common missense variant of monocarboxylate transporter 9 (MCT9/SLC16A9) gene is associated with renal overload gout, but not with all gout susceptibility. Hum Cell. 2013 Dec;26(4):133-6.
• [3] Concentration-dependent mode of interaction of angiotensin II receptor blockers with uric acid transporter. J Pharmacol Exp Ther. 2007 Jan;320(1):211-7.
• [4] Involvement of uric acid transporters in alteration of serum uric acid level by angiotensin II receptor blockers. Pharm Res. 2008 Mar;25(3):639-46.
• [5] Extra-renal elimination of uric acid via intestinal efflux transporter BCRP/ABCG2. PLoS One. 2012;7(2):e30456.
• [6] Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013 Feb;45(2):145-54. doi: 10.1038/ng.2500. Epub 2012 Dec 23.
• [7] Identification of low-frequency variants associated with gout and serum uric acid levels. Nat Genet. 2011 Oct 9;43(11):1127-30. doi: 10.1038/ng.972.
• [8] Uric acid activates aldose reductase and the polyol pathway for endogenous fructose and fat production causing development of fatty liver in rats. J Biol Chem. 2019 Mar 15;294(11):4272-4281. doi: 10.1074/jbc.RA118.006158. Epub 2019 Jan 16.
• [9] Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice. Biochim Biophys Acta. 2016 Nov;1862(11):2034-2042. doi: 10.1016/j.bbadis.2016.08.010. Epub 2016 Aug 16.
• [10] Resveratrol inhibits the intracellular calcium increase and angiotensin/endothelin system activation induced by soluble uric acid in mesangial cells. Braz J Med Biol Res. 2015 Jan;48(1):51-56. doi: 10.1590/1414-431x20144032. Epub 2014 Oct 24.
• [11] Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites. Am J Physiol Renal Physiol. 2005 Feb;288(2):F327-33. doi: 10.1152/ajprenal.00133.2004. Epub 2004 Sep 28.
• [12] Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells. J Am Soc Nephrol. 2009 Mar;20(3):545-53. doi: 10.1681/ASN.2008060576. Epub 2009 Jan 21.
• [13] Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008 May 2;320(5876):674-7. doi: 10.1126/science.1156995. Epub 2008 Apr 10.
• [14] Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
• [15] Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
• [16] The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
• [17] Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
• [18] Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
• [19] Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
• [20] The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
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