Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTK234)

• Drug Name: Piroxicam Drug Info
• Synonyms: Akten; Artroxicam; Bruxicam; Caliment; Erazon; Felden; Feldene; Flogobene; Geldene; Improntal; Larapam; Pipoxicam; Pirkam; Piroflex; Piroftal; Piroxicamum; Pyroxycam; Reudene; Riacen; Roxicam; Roxiden; Sasulen; Solocalm; Zunden; Feldene Fast; Feldene Gel; Piroxicam usp; AK1015; CHF 1251; CP 16171; CP16171; P 5654; Apo-Piroxicam; Brexidol (TN); Brexin (TN); CP-16171; Erazon (TN); Exipan (TN); Felden (TN); Feldene (TN); Feldoral (TN); Hotemin (TN); Mobilis (TN); Pirox von ct (TN); Piroxicamum [INN-Latin]; Proponol (TN); Reumador (TN); Tracam (TN); Veral (TN); Vurdon (TN); Feldene, Roxam, Piroxicam; Piroxicam (JP15/USP/INN); Piroxicam [USAN:BAN:INN:JAN]; (3E)-3-[hydroxy-(pyridin-2-ylamino)methylidene]-2-methyl-1,1-dioxo-1; (4-Hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazin-3-yl)-N-(2-pyridyl)carboxamide; 2H-1,2-Benzothiazine-3-carboxamide, 4-hydroxy-2-methyl-N-2-pyridinyl-, 1,1-dioxide; 3-[hydroxy(pyridin-2-ylamino)methylidene]-2-methyl-3,4-dihydro-2H-1; 4-Hydroxy-2-methyl-3-(pyrid-2-yl-carbamoyl)-2H-1,2-benzothiazine 1,1-dioxide; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazin-3-caboxyamid-1,1-dioxid [German]; 4-Hydroxy-2-methyl-N-(2-pyridyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide; 4-Hydroxy-2-methyl-N-2-pyridyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; 4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide; 4-hydroxy-2-methyl-N-pyridin-2-yl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide

Indication

Disease Entry	ICD 11	Status	REF
Osteoarthritis	FA00-FA05	Approved	[1]
Pain	MG30-MG3Z	Approved	[2]

• Therapeutic Class: Analgesics
• Cross-matching ID:
  PubChem CID: 54676228
  ChEBI ID: CHEBI:8249
  CAS Number: CAS 36322-90-4
  TTD Drug ID: DMTK234
  VARIDT Drug ID: DR00481
  INTEDE Drug ID: DR1300
  ACDINA Drug ID: D00537

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[8]
Naproxen	DMZ5RGV	Bursitis		Approved	[9]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[10]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[11]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[12]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[3]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[13]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[14]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[15]
FENBUFEN	DMXGDFK	Arthritis	FA20	Approved	[16]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[18]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[18]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[20]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[21]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[22]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[18]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[23]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[24]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[19]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[19]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[29]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[30]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[32]

Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[33]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[35]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[36]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[35]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[38]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[43]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[37]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[44]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Organic anion transporter 7 (SLC22A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[47]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]

Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[51]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[37]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[53]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[55]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[55]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[55]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[55]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[55]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[55]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[35]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[56]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[61]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[65]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[66]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[66]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By Calmegin (CLGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[89]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[91]

Drug(s) Affected By Gasdermin-E (GSDME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[100]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[97]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[103]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[104]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[106]

Drug(s) Affected By Antiviral innate immune response receptor RIG-I (RIGI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[110]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[112]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[122]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[133]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[136]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[140]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[142]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[143]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[144]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[144]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[148]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[146]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Haloperidol	DM96SE0	Delirium		Approved	[151]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[149]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[153]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[159]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[160]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[136]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[164]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[144]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[166]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[178]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[50]

Drug(s) Affected By Adenosine receptor A2a (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[184]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[187]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[188]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[191]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[192]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[198]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]

Drug(s) Affected By Spermine synthase (SMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[202]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[203]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[205]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[208]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[101]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]

Drug(s) Affected By Nidogen-2 (NID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[214]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[218]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[219]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[220]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Lymphocyte antigen 6E (LY6E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Collectin-12 (COLEC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]

Drug(s) Affected By Olfactomedin-like protein 2B (OLFML2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[224]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[92]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[227]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19B (RNF19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[229]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]

Drug(s) Affected By Amphoterin-induced protein 2 (AMIGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[230]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[221]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]

Drug(s) Affected By Latexin (LXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[234]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[235]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Bortezomib	DMNO38U	Leukemia		Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]

Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[240]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[198]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]

Drug(s) Affected By Large neutral amino acids transporter small subunit 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]

Drug(s) Affected By Paired immunoglobulin-like type 2 receptor alpha (PILRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[247]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[144]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[251]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[144]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By ATP-dependent RNA helicase DDX39A (DDX39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 12 (PSMD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]

Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[257]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[259]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]

Drug(s) Affected By ATP-dependent RNA helicase DDX3X (DDX3X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[263]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[265]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[266]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[266]
Fructose	DM43AN2	Vomiting	MD90	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[266]

Drug(s) Affected By Eukaryotic translation initiation factor 1A, Y-chromosomal (EIF1AY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[270]

Drug(s) Affected By Homeobox protein Meis2 (MEIS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[271]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[113]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[113]

Drug(s) Affected By Kinetochore protein NDC80 homolog (NDC80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[255]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[276]

Drug(s) Affected By Histone acetyltransferase type B catalytic subunit (HAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]

Drug(s) Affected By Sphingolipid delta(4)-desaturase DES1 (DEGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]

Drug(s) Affected By Membrane-associated progesterone receptor component 2 (PGRMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[286]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[287]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]

Drug(s) Affected By Serine palmitoyltransferase 2 (SPTLC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[289]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]

Drug(s) Affected By Apoptosis regulatory protein Siva (SIVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[198]
Bortezomib	DMNO38U	Leukemia		Approved	[293]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[296]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[299]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[301]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[303]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[198]

Drug(s) Affected By Cytochrome b5 type B (CYB5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[306]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[308]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[309]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[310]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[311]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[314]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]

Drug(s) Affected By Tetraspanin-6 (TSPAN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 5 (NUDT21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SMARCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[252]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Dynamin-like 120 kDa protein, mitochondrial (OPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[324]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[276]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]

Drug(s) Affected By Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[326]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[326]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[328]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Eukaryotic translation initiation factor 4E type 2 (EIF4E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[330]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Protein diaphanous homolog 1 (DIAPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[332]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[333]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Cell cycle checkpoint protein RAD1 (RAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[334]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[335]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[336]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[337]

Drug(s) Affected By Eukaryotic translation initiation factor 5B (EIF5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[326]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]

Drug(s) Affected By Ribonuclease H1 (RNASEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[339]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[340]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[339]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[341]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[342]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]

Drug(s) Affected By Filamin-B (FLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[344]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]

Drug(s) Affected By Histone deacetylase complex subunit SAP30 (SAP30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[347]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[348]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Serine/arginine-rich splicing factor 10 (SRSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[349]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[306]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]

Drug(s) Affected By Geminin (GMNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Heat shock factor-binding protein 1 (HSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[86]

Drug(s) Affected By Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial (SLC25A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[308]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]

Drug(s) Affected By Breast cancer anti-estrogen resistance protein 3 (BCAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[356]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[198]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[198]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]

Drug(s) Affected By Ribonuclease P protein subunit p20 (POP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[357]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[358]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit J (EIF3J)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[359]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Cell cycle checkpoint protein RAD17 (RAD17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[361]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[362]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
OXYBENZONE	DMMZYX6	Discovery agent	N.A.	Investigative	[364]

Drug(s) Affected By Protein HEXIM1 (HEXIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]

Drug(s) Affected By Reticulon-3 (RTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[367]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[330]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By 6-phosphogluconolactonase (PGLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[361]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]

Drug(s) Affected By Structural maintenance of chromosomes protein 2 (SMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]

Drug(s) Affected By Importin-7 (IPO7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[333]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[371]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[372]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[373]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[374]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[375]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[376]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[377]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[378]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[379]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[380]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[381]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[382]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[383]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[384]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[385]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[386]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[389]
Fructose	DM43AN2	Vomiting	MD90	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[391]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[392]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[394]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[398]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[393]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[399]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[400]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[401]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[402]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[403]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[404]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[407]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[229]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[410]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[412]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[413]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[414]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[416]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[417]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]

Drug(s) Affected By Alpha-galactosidase A (GLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[418]
Bortezomib	DMNO38U	Leukemia		Approved	[236]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[421]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[424]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[430]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[431]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[432]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[433]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[435]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[436]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[435]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Prosaposin (PSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[259]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[308]

Drug(s) Affected By Complement decay-accelerating factor (CD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[198]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[439]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[439]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[440]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[439]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]

Drug(s) Affected By U1 small nuclear ribonucleoprotein A (SNRPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[441]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[112]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[444]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[445]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[447]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[448]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[449]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[449]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[450]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[451]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[452]

Drug(s) Affected By U2 small nuclear ribonucleoprotein A' (SNRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[230]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[326]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[371]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[455]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[457]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[458]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[460]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[461]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[408]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Indomethacin	DMSC4A7	Bursitis		Approved	[463]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[464]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[430]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[400]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[466]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[467]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[468]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[469]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[469]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[469]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[472]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Transcription factor E2-alpha (TCF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[473]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[474]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[280]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[326]

Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[475]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[476]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[477]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[479]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[480]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[481]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[482]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[483]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[484]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[485]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[486]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[487]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[488]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[489]

Drug(s) Affected By SH2/SH3 adapter protein NCK1 (NCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[490]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[491]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[492]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[457]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[162]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[496]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[497]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[498]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[499]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[500]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[501]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[412]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[502]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[495]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[503]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[505]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[506]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[465]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[466]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]

Drug(s) Affected By Calpastatin (CAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[214]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[512]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[514]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[515]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[252]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[315]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]

Drug(s) Affected By Glycine cleavage system H protein, mitochondrial (GCSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By 40-kDa huntingtin-associated protein (F8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[516]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]

Drug(s) Affected By Thymidylate kinase (DTYMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[519]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[520]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[377]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[521]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[522]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[523]

Drug(s) Affected By Cyclin-C (CCNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[430]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[524]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[525]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[526]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[527]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[528]
Inecalcitol oral	DMU5SZP	Acute myeloid leukaemia	2A60	Phase 2	[529]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[429]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[530]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[531]
Selenium	DM25CGV	N. A.	N. A.	Approved	[430]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[532]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[533]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[534]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[456]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[495]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]

Drug(s) Affected By Proteasome subunit alpha type-2 (PSMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[536]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[537]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[277]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[538]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[540]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[541]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[542]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[543]

Drug(s) Affected By ATP-binding cassette sub-family D member 3 (ABCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[120]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[544]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[545]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[547]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[280]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[377]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[548]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[550]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[496]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[426]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[551]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[552]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[553]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[554]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Homeobox protein Hox-A9 (HOXA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[556]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[557]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
EPZ-004777	DMLN4V5	leukaemia	2A60-2B33	Investigative	[558]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[559]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[560]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[461]
Haloperidol	DM96SE0	Delirium		Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[561]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[561]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[562]

Drug(s) Affected By Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[563]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]

Drug(s) Affected By ER lumen protein-retaining receptor 2 (KDELR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[564]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[565]

Drug(s) Affected By Dual specificity protein kinase TTK (TTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Polycomb group RING finger protein 2 (PCGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[147]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[496]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[361]

Drug(s) Affected By Replication factor C subunit 2 (RFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[566]

Drug(s) Affected By Prostaglandin E2 receptor EP4 subtype (PTGER4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[284]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[568]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[569]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[501]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[570]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[571]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[572]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]

Drug(s) Affected By 26S proteasome regulatory subunit 7 (PSMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[573]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[574]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[575]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[576]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[577]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[578]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[294]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[297]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[579]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[532]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]

Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[580]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]

Drug(s) Affected By Macrophage-capping protein (CAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 1 (PBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[581]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[562]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Condensin-2 complex subunit D3 (NCAPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[582]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]

Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[583]
Haloperidol	DM96SE0	Delirium		Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[584]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[585]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[586]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Ran-specific GTPase-activating protein (RANBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[449]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[449]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[587]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[588]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[366]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[590]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]

Drug(s) Affected By ATP-dependent DNA helicase Q1 (RECQL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By F-actin-capping protein subunit alpha-2 (CAPZA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[561]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[333]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]

Drug(s) Affected By Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[110]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[591]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]

Drug(s) Affected By Glioma pathogenesis-related protein 1 (GLIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[515]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[592]

Drug(s) Affected By Casein kinase I isoform alpha (CSNK1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[593]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Ribose-5-phosphate isomerase (RPIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[515]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Nuclear autoantigenic sperm protein (NASP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[198]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Haloperidol	DM96SE0	Delirium		Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]

Drug(s) Affected By RNA-binding protein 25 (RBM25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[593]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[561]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[264]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[537]
Bortezomib	DMNO38U	Leukemia		Approved	[595]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[595]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[308]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[596]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[340]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[597]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[598]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Importin subunit alpha-5 (KPNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[597]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]

Drug(s) Affected By Arf-GAP domain and FG repeat-containing protein 1 (AGFG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[249]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[258]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[198]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[198]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Sodium/myo-inositol cotransporter (SLC5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[599]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]

Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[149]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[600]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Adenylate kinase 2, mitochondrial (AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[255]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[601]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[602]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Mesencephalic astrocyte-derived neurotrophic factor (MANF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]

Drug(s) Affected By Nucleosome assembly protein 1-like 1 (NAP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[603]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[604]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[605]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Methionine--tRNA ligase, cytoplasmic (MARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[606]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[332]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[270]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 1 (PRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[607]

Drug(s) Affected By Ras-related protein Rab-8A (RAB8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[606]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[528]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[608]

Drug(s) Affected By Protein mago nashi homolog (MAGOH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[609]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[610]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[611]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[560]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[437]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[599]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[612]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[86]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[613]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[614]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[615]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]

Drug(s) Affected By Ras-related protein Rab-1A (RAB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]

Drug(s) Affected By S-phase kinase-associated protein 1 (SKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[418]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[616]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Selenoprotein W (SELENOW)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[617]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[618]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[619]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[620]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[621]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[622]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[623]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[624]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[625]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[626]

Drug(s) Affected By Receptor expression-enhancing protein 5 (REEP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[627]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[491]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[628]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[629]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[408]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[478]

Drug(s) Affected By RNA-binding protein EWS (EWSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[584]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[584]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[630]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[631]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[519]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[59]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[632]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[633]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[634]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[635]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[478]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[637]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[638]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[639]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[635]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Exosome complex component RRP45 (EXOSC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[515]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[640]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[641]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Bortezomib	DMNO38U	Leukemia		Approved	[236]

Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[605]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[606]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[642]

Drug(s) Affected By Histone-binding protein RBBP4 (RBBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]

Drug(s) Affected By Heat shock 70 kDa protein 14 (HSPA14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[335]

Drug(s) Affected By Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Nuclear pore complex protein Nup160 (NUP160)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Splicing factor 3A subunit 3 (SF3A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[643]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[609]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]

Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[644]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[308]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[645]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[646]

Drug(s) Affected By Protein tyrosine phosphatase type IVA 2 (PTP4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[647]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[130]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[648]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[360]

Drug(s) Affected By Serine/arginine-rich splicing factor 6 (SRSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[272]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[649]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Centromere protein R (ITGB3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[613]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[650]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[651]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[652]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[387]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 21 (MED21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By NGFI-A-binding protein 1 (NAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[356]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[326]

Drug(s) Affected By Serine/threonine-protein kinase PRP4 homolog (PRP4K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By G/T mismatch-specific thymine DNA glycosylase (TDG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[326]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[326]

Drug(s) Affected By KRR1 small subunit processome component homolog (KRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[326]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[333]

Drug(s) Affected By Cullin-4B (CUL4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[653]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[441]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[654]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[655]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[656]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[657]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[658]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[346]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Next to BRCA1 gene 1 protein (NBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[315]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[318]

Drug(s) Affected By Plastin-1 (PLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]

Drug(s) Affected By DNA replication complex GINS protein PSF1 (GINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Delta(14)-sterol reductase LBR (LBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]

Drug(s) Affected By Importin subunit beta-1 (KPNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[597]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[597]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Haloperidol	DM96SE0	Delirium		Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Signal peptidase complex subunit 2 (SPCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[357]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[270]

Drug(s) Affected By IQ calmodulin-binding motif-containing protein 1 (IQCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[660]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By DNA polymerase delta subunit 3 (POLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Kinesin-like protein KIF14 (KIF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]

Drug(s) Affected By 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]

Drug(s) Affected By Calponin-3 (CNN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[361]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Telomeric repeat-binding factor 2 (TERF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[661]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[662]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[663]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[87]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[664]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[665]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[666]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[667]

Drug(s) Affected By High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[302]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By Coiled-coil domain-containing protein 85B (CCDC85B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[668]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[486]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[669]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[670]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[671]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[672]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[508]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]

Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[280]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[561]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[673]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[674]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[361]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[675]

Drug(s) Affected By Mesoderm-specific transcript homolog protein (MEST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[676]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[326]

Drug(s) Affected By Centrosomal protein of 170 kDa (CEP170)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[453]

Drug(s) Affected By All trans-polyprenyl-diphosphate synthase PDSS1 (PDSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[677]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[565]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]

Drug(s) Affected By ATPase family AAA domain-containing protein 2 (ATAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[198]

Drug(s) Affected By CREB-regulated transcription coactivator 3 (CRTC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[678]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]

Drug(s) Affected By LHFPL tetraspan subfamily member 2 protein (LHFPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[679]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[357]

Drug(s) Affected By PAX-interacting protein 1 (PAXIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[453]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By Heparan sulfate 2-O-sulfotransferase 1 (HS2ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[679]

Drug(s) Affected By L-xylulose reductase (DCXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[239]

Drug(s) Affected By Neuroepithelial cell-transforming gene 1 protein (NET1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]

Drug(s) Affected By Adiponectin receptor protein 2 (ADIPOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[681]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[103]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[683]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Cullin-associated NEDD8-dissociated protein 1 (CAND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[645]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[684]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[645]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[358]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[147]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[631]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]

Drug(s) Affected By RING1 and YY1-binding protein (RYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[656]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Misshapen-like kinase 1 (MINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[110]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[110]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By THO complex subunit 2 (THOC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[627]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Atypical kinase COQ8A, mitochondrial (COQ8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[677]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[288]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[685]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[686]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]

Drug(s) Affected By Kinesin-like protein KIF18A (KIF18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[687]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Serine/threonine-protein kinase Nek9 (NEK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[688]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[528]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[453]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF139 (RNF139)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[689]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[690]

Drug(s) Affected By PH-interacting protein (PHIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[453]

Drug(s) Affected By Palladin (PALLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]

Drug(s) Affected By DnaJ homolog subfamily C member 9 (DNAJC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[495]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]

Drug(s) Affected By Transmembrane protein 158 (TMEM158)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[103]

Drug(s) Affected By C-type lectin domain family 2 member B (CLEC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[264]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[691]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[264]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]

Drug(s) Affected By DNA topoisomerase 2-binding protein 1 (TOPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[692]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[561]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[560]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[693]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[694]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[695]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[643]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Optineurin (OPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[696]

Drug(s) Affected By U5 small nuclear ribonucleoprotein 40 kDa protein (SNRNP40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[697]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[698]

Drug(s) Affected By Protein Spindly (SPDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Kinetochore-associated protein NSL1 homolog (NSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Serine protease FAM111A (FAM111A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]

Drug(s) Affected By Sperm-associated antigen 5 (SPAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[251]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[354]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]

Drug(s) Affected By c-Myc-binding protein (MYCBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[699]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Nuclear pore complex protein Nup88 (NUP88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[700]

Drug(s) Affected By Phosphoinositide 3-kinase regulatory subunit 4 (PIK3R4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[701]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]

Drug(s) Affected By Cell division cycle-associated protein 3 (CDCA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Pre-mRNA-splicing factor 18 (PRPF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[702]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[703]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[449]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[552]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[704]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[705]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[705]

Drug(s) Affected By Probable rRNA-processing protein EBP2 (EBNA1BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[706]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[707]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[708]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[496]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By DNA replication complex GINS protein PSF3 (GINS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By TIMELESS-interacting protein (TIPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[228]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[228]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[228]

Drug(s) Affected By Nuclear pore complex protein Nup85 (NUP85)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[709]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[453]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[593]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]

Drug(s) Affected By Cell division cycle-associated protein 4 (CDCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[660]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]

Drug(s) Affected By Charged multivesicular body protein 4a (CHMP4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[710]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[711]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[712]

Drug(s) Affected By Large ribosomal subunit protein uL13m (MRPL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[357]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[358]

Drug(s) Affected By Pantothenate kinase 2, mitochondrial (PANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[308]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[713]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[243]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]

Drug(s) Affected By Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[714]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[225]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[715]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[716]

Drug(s) Affected By Pinin (PNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[584]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[584]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[79]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]

Drug(s) Affected By Thioredoxin-related transmembrane protein 1 (TMX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]

Drug(s) Affected By MOB kinase activator 1A (MOB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[333]

Drug(s) Affected By Protein ECT2 (ECT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Calcyclin-binding protein (CACYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By NTF2-related export protein 2 (NXT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[363]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]

Drug(s) Affected By Endothelial cell-specific molecule 1 (ESM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[717]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[718]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[719]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[716]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[557]

Drug(s) Affected By Neural proliferation differentiation and control protein 1 (NPDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[720]

Drug(s) Affected By GTP-binding protein SAR1a (SAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[330]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[710]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[721]

Drug(s) Affected By DNA polymerase epsilon subunit 3 (POLE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[581]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[280]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[45]

Drug(s) Affected By Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]

Drug(s) Affected By BMP-2-inducible protein kinase (BMP2K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[254]
Indomethacin	DMSC4A7	Bursitis		Approved	[242]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By ATP-dependent RNA helicase DDX19A (DDX19A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Fanconi anemia group I protein (FANCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[722]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]

Drug(s) Affected By Notchless protein homolog 1 (NLE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[659]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]

Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[239]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[280]

Drug(s) Affected By Large ribosomal subunit protein uL16m (MRPL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]

Drug(s) Affected By H/ACA ribonucleoprotein complex subunit 1 (GAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[332]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Dipeptidyl peptidase 3 (DPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[723]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[724]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[660]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
Leucine-enkephalin	DMT2CZK	Discovery agent	N.A.	Investigative	[725]

Drug(s) Affected By Protein downstream neighbor of Son (DONSON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[263]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Protein Mis18-alpha (MIS18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[726]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By BRCA2 and CDKN1A-interacting protein (BCCIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[697]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[727]

Drug(s) Affected By Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[581]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[723]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[326]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[326]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[710]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[228]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[567]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[233]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[221]

Drug(s) Affected By Protein sel-1 homolog 1 (SEL1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[513]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]

Drug(s) Affected By Tight junction protein ZO-2 (TJP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[728]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]

Drug(s) Affected By Serine/threonine-protein kinase 17A (STK17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[212]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[332]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[7]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[7]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[7]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[7]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]

Drug(s) Affected By Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[679]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[729]

Drug(s) Affected By F-box only protein 9 (FBXO9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[105]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[86]

Drug(s) Affected By PR domain zinc finger protein 4 (PRDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[562]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[730]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]

Drug(s) Affected By Thyrotropin-releasing hormone-degrading ectoenzyme (TRHDE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[660]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]

Drug(s) Affected By Nuclear pore complex protein Nup50 (NUP50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[453]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[151]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By BAG family molecular chaperone regulator 5 (BAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[113]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[627]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[731]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[270]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By Cip1-interacting zinc finger protein (CIZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[245]

Drug(s) Affected By Nuclear pore complex-interacting protein family member A1 (NPIPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[222]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[641]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[270]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[732]

Drug(s) Affected By Protein kinase C and casein kinase substrate in neurons protein 2 (PACSIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[284]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[679]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[698]

Drug(s) Affected By Translocon-associated protein subunit gamma (SSR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[583]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By COP9 signalosome complex subunit 3 (COPS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[723]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[733]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[453]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[238]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[45]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By SH2B adapter protein 3 (SH2B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[648]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By DNA replication complex GINS protein PSF2 (GINS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[734]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[734]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]

Drug(s) Affected By Trafficking protein particle complex subunit 4 (TRAPPC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[648]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[735]

Drug(s) Affected By Afadin- and alpha-actinin-binding protein (SSX2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[642]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[736]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC10 (POLR3K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[332]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[285]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[697]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[357]

Drug(s) Affected By Endophilin-B1 (SH3GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[495]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[280]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 7 (TMED7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]

Drug(s) Affected By Insulin receptor substrate 2 (IRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[737]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[738]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[417]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[739]

Drug(s) Affected By V-type proton ATPase subunit D (ATP6V1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[264]

Drug(s) Affected By Origin recognition complex subunit 6 (ORC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[176]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[199]

Drug(s) Affected By Sorting nexin-5 (SNX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[147]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[306]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[740]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[698]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[680]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[198]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 1 (EID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[729]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[741]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[721]

Drug(s) Affected By Calpain-7 (CAPN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[320]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[241]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[698]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[147]

Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[742]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[743]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[744]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[745]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[469]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[746]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[747]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[748]

Drug(s) Affected By L-selectin (SELL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[749]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[749]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[750]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[749]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[751]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[749]
Phenylbutazone	DMAYL0T	Chronic pain	MG30	Approved	[749]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]

Drug(s) Affected By HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[469]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ethosuximide	DMDZ9LT	Epilepsy	8A60-8A68	Approved	[469]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[213]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[469]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[752]
Bortezomib	DMNO38U	Leukemia		Approved	[236]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[110]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[753]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[754]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[755]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[756]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[580]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[303]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[757]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[758]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[45]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[469]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[130]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[469]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[469]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[469]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]

Drug(s) Affected By Glycogen synthase, muscle (GYS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[759]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[737]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[262]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[226]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[4]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Gene/Protein Processing	[6]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[7]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[6]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Gene/Protein Processing	[6]
26S proteasome regulatory subunit 7 (PSMC2)	OTJ4V337	PRS7_HUMAN	Gene/Protein Processing	[6]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Gene/Protein Processing	[6]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[6]
40-kDa huntingtin-associated protein (F8A1)	OTXTQ59R	HAP40_HUMAN	Gene/Protein Processing	[6]
6-phosphogluconolactonase (PGLS)	OTO6C0IQ	6PGL_HUMAN	Gene/Protein Processing	[6]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Gene/Protein Processing	[6]

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