General Information of Disease (ID: DIS61J3S)

Disease Name Hyperlipidemia
Synonyms hyperlipemia; lipemia; lipemias; lipidemia; lipidemias; hyperlipemias; hyperlipidemia (disease); hyperlipidemia
Disease Class 5C80: Hyperlipidemia
Disease Hierarchy
DIS71G5H: Metabolic disorder
DIS61J3S: Hyperlipidemia
ICD Code
ICD-11
ICD-11: 5C80.Z
Disease Identifiers
MONDO ID
MONDO_0021187
MESH ID
D006949
UMLS CUI
C0020473
MedGen ID
5692
HPO ID
HP:0003077
SNOMED CT ID
55822004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 14 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Atorvastatin DMF28YC Approved Small molecular drug [1]
Bezafibrate DMZDCS0 Approved Small molecular drug [2]
Cholecalciferol DMGU74E Approved Small molecular drug [3]
Cholestyramine DM3370M Approved NA [4]
Colestipol DMIRPD8 Approved Small molecular drug [5]
Ezetimibe DM7A8TW Approved Small molecular drug [6]
Fenofibrate DMFKXDY Approved Small molecular drug [7]
Levothyroxine DMHN027 Approved Small molecular drug [8]
Lovastatin DM9OZWQ Approved Small molecular drug [9]
Pemafibrate DMD1VZL Approved NA [10]
Probucol DMVZQ2M Approved Small molecular drug [11]
Simvastatin DM30SGU Approved Small molecular drug [12]
Topiramate DM82Z30 Approved Small molecular drug [13]
Vitamin B3 DMQVRZH Approved Small molecular drug [14]
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⏷ Show the Full List of 14 Drug(s)
This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
N1-methylnicotinamide DM16PWF Phase 2/3 Small molecular drug [15]
SLN360 DMVVU4V Phase 2 RNA interference [16]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 74 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ABCB1 TT3OT40 Limited Biomarker [17]
ACAT1 TTK3C21 Limited Genetic Variation [18]
ACHE TT1RS9F Limited Altered Expression [19]
ANGPTL3 TT59GO7 Limited Biomarker [20]
APOC3 TTXOZQ1 Limited Biomarker [21]
ARSA TTYQANR Limited Biomarker [22]
ASRGL1 TT4WT91 Limited Altered Expression [23]
CETP TTFQAYR Limited Biomarker [24]
ERN1 TTKIAT3 Limited Biomarker [25]
F7 TTF0EGX Limited Biomarker [26]
FDFT1 TTFQEO5 Limited Biomarker [27]
FGF21 TTQ916P Limited Biomarker [28]
GCG TT6Y4PN Limited Biomarker [29]
HSD11B1 TTN7BL9 Limited Biomarker [30]
LIPA TTS8T1M Limited Biomarker [31]
MGAM TTXWASR Limited Altered Expression [32]
NPC1L1 TTPD1CN Limited Biomarker [33]
NR1H4 TTS4UGC Limited Biomarker [34]
PCSK9 TTNIZ2B Limited Biomarker [35]
PPARGC1B TTKSQ3W Limited Biomarker [36]
SDC1 TTYDSVG Limited Biomarker [37]
SERPINC1 TT4QPUL Limited Biomarker [38]
SLC17A5 TTFSUIA Limited Altered Expression [39]
SORT1 TTRX9AV Limited Biomarker [40]
SREBF1 TTER0UB Limited Altered Expression [41]
ABCA1 TTJW1GN moderate Genetic Variation [42]
ADIPOQ TTXKA7D moderate Biomarker [43]
LEP TTBJEZ5 moderate Genetic Variation [44]
MTTP TTUS1RD moderate Genetic Variation [45]
ABCG5 TTKZ7WY Strong Genetic Variation [46]
ACLY TT0Z6Y2 Strong Biomarker [47]
ADRB2 TTG8ZWP Strong Biomarker [48]
ALB TTFNGC9 Strong Altered Expression [49]
AMY2A TTCGSZ4 Strong Biomarker [50]
APOA2 TTGQA9W Strong Biomarker [51]
APOA4 TTNC3WS Strong Genetic Variation [52]
APOB TTN1IE2 Strong Biomarker [53]
AQP7 TTNGCRK Strong Altered Expression [54]
CD36 TTPJMCU Strong Biomarker [55]
CES1 TTMF541 Strong Biomarker [56]
CPE TTXPWO6 Strong Biomarker [57]
CYP2E1 TTWVHQ5 Strong Altered Expression [58]
DGAT2 TTRHEQ4 Strong Biomarker [59]
EHMT1 TTOFXD7 Strong Biomarker [29]
FABP1 TTIV96N Strong Genetic Variation [60]
GLP1R TTVIMDE Strong Biomarker [29]
HMGCR TTPADOQ Strong Biomarker [61]
ID2 TTW8A5N Strong Genetic Variation [62]
IRS1 TTAJSQ0 Strong Biomarker [63]
KLB TTARBVH Strong Altered Expression [64]
LCAT TTGZ91P Strong Biomarker [65]
LDLR TTH0DUS Strong Biomarker [66]
LEPR TT0HD6V Strong Genetic Variation [44]
LPA TTU9LGY Strong Biomarker [67]
NOS3 TTCM4B3 Strong Altered Expression [68]
NR1H3 TTECBXN Strong Biomarker [69]
PAOX TTNQ760 Strong Biomarker [70]
PCSK7 TTD30LY Strong Biomarker [71]
PDE3B TTN34SQ Strong Genetic Variation [72]
PLK4 TTGPNZQ Strong Biomarker [73]
PNPLA3 TTEUAEH Strong Genetic Variation [74]
PPARA TTJ584C Strong Altered Expression [75]
S1PR4 TTZ8C5Q Strong Biomarker [76]
SERPIND1 TT8XSKJ Strong Biomarker [77]
SIRT3 TTVZLIJ Strong Altered Expression [78]
SLC27A4 TT20AYF Strong Genetic Variation [79]
SLC2A4 TTP6MT5 Strong Biomarker [55]
SLC40A1 TT6Y1PG Strong Biomarker [80]
SLCO1B1 TTFGXEB Strong Biomarker [81]
SOAT2 TTAK0IN Strong Genetic Variation [82]
SREBF2 TTRQ4AP Strong Biomarker [83]
TLR6 TTWRI8V Strong Biomarker [84]
TNFRSF25 TTDV6BQ Strong Genetic Variation [85]
VCAM1 TTHCEF6 Strong Altered Expression [86]
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⏷ Show the Full List of 74 DTT(s)
This Disease Is Related to 3 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC27A1 DTKDTML Limited Biomarker [87]
SLC4A7 DT03V27 Strong Genetic Variation [88]
SLC52A3 DTBVQIO Strong Biomarker [89]
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This Disease Is Related to 10 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
CYP7A1 DEDZRQ1 Limited Biomarker [65]
SI DE5EO4Y Limited Altered Expression [32]
APRT DE2MV1R Strong Genetic Variation [90]
AS3MT DE9KJP3 Strong Genetic Variation [91]
CHDH DEAHED0 Strong Biomarker [92]
CYP27A1 DEBS639 Strong Biomarker [93]
GPT DER5HFI Strong Biomarker [94]
KYAT1 DES9MCU Strong Biomarker [95]
NAT10 DEZV4AP Strong Altered Expression [23]
SMOX DEOH5V3 Strong Biomarker [70]
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⏷ Show the Full List of 10 DME(s)
This Disease Is Related to 96 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
APOBEC1 OTY8QX2R Limited Biomarker [96]
APOC2 OTLINYIQ Limited Genetic Variation [97]
C5AR2 OTP1Q82J Limited Genetic Variation [98]
DVL2 OTMNYNCM Limited Altered Expression [99]
ELF3 OTUTLEQO Limited Genetic Variation [100]
GFPT1 OTQBDO45 Limited Biomarker [101]
INPP5F OTPKUY50 Limited Biomarker [102]
JPH3 OTHTJO2I Limited Genetic Variation [103]
KL OTD4VWU6 Limited Biomarker [104]
LMX1B OTM8145D Limited Biomarker [105]
PLXNA1 OTN0BING Limited Altered Expression [106]
RGN OTD04KB1 Limited Biomarker [107]
RPL10 OTBHOZGC Limited Altered Expression [106]
SERPINF2 OTZGAF8B Limited Biomarker [108]
SHC1 OT1J5IRN Limited Biomarker [109]
SMARCD1 OTHFFT6G Limited Biomarker [110]
CHPT1 OT4FJ0K3 Disputed Biomarker [111]
CPT1A OTI862QH Disputed Biomarker [111]
CPT2 OTIN6G20 Disputed Biomarker [111]
MICU1 OTS7N0LE Disputed Altered Expression [112]
ST3GAL4 OTNENJZQ Disputed Altered Expression [113]
NFAT5 OTKIE59S moderate Biomarker [114]
ABCG8 OTIJ76XW Strong Biomarker [115]
ABHD2 OTCRUOCS Strong Biomarker [116]
ACADSB OTDO6HBG Strong Genetic Variation [117]
ACAT2 OTZ092ZJ Strong Genetic Variation [82]
ACSL3 OT3MWER1 Strong Altered Expression [118]
ACSL5 OT3L9XO3 Strong Altered Expression [118]
ADAMTS7 OTVKZ1DV Strong Biomarker [119]
ANGPTL8 OTQFINCD Strong Altered Expression [120]
APC OTKV0TIK Strong Biomarker [121]
APOA5 OTEVKLVA Strong Genetic Variation [122]
APOF OT12S5QS Strong Biomarker [123]
APOM OTI3FQQC Strong Altered Expression [124]
ATAD1 OTJ02XFL Strong Biomarker [125]
ATRNL1 OTY5JUX2 Strong Altered Expression [23]
BUD13 OTXG6MX5 Strong Genetic Variation [126]
CD1B OT4D5EG7 Strong Biomarker [127]
CD1C OT4XINUJ Strong Biomarker [127]
CDC73 OT6JASZ1 Strong Biomarker [128]
CDCP1 OTD7RRWK Strong Biomarker [128]
CNBP OTTGM9NK Strong Altered Expression [129]
DHX40 OTOL02QN Strong Biomarker [130]
DISC1 OT43AW4H Strong Biomarker [128]
DNAJB9 OT38EQT6 Strong Biomarker [131]
DOCK7 OTINNVQV Strong Genetic Variation [132]
DYM OTQ670WI Strong Biomarker [133]
EDA OTAKS5WS Strong Biomarker [134]
FAM13A OTZ6GN0Q Strong Biomarker [116]
FAM20C OTW5YZ7X Strong Biomarker [135]
FCN1 OTK6ZHXH Strong Biomarker [76]
FGL1 OTT0QHQ1 Strong Altered Expression [136]
FNDC4 OTOQK0WK Strong Biomarker [137]
FNDC5 OT5CSK9X Strong Altered Expression [138]
GALNT2 OTZZ5386 Strong Genetic Variation [132]
GOLGA6A OTHU9MRX Strong Biomarker [139]
GPIHBP1 OTDF8R2M Strong Biomarker [140]
GPR162 OTK4LT3K Strong Biomarker [141]
GREB1 OTU6ZA26 Strong Genetic Variation [142]
HAT1 OT307KEN Strong Biomarker [95]
HELZ2 OTM6HVO6 Strong Biomarker [143]
IL1F10 OTJAASGC Strong Altered Expression [144]
KDM4B OT5P1UPY Strong Biomarker [145]
LAD1 OT6YGTVX Strong Biomarker [146]
LAMA1 OTQZMP86 Strong Biomarker [147]
LIPC OTZY5SC9 Strong Biomarker [148]
LRP8 OTZ71YV2 Strong Altered Expression [149]
MARK4 OT6Z2TGV Strong Altered Expression [150]
MFAP1 OTZN4FT3 Strong Genetic Variation [90]
MFSD2A OTVG1VG0 Strong Biomarker [151]
MID1IP1 OTFCORJM Strong Biomarker [152]
MLXIPL OTR9MLLW Strong Altered Expression [153]
MT1B OTUA4FFH Strong Genetic Variation [60]
MYO1F OTOAV4AR Strong Biomarker [76]
NANOS3 OTGX9IQU Strong Biomarker [154]
NCF2 OTAUW7L2 Strong Biomarker [76]
NEIL1 OTHBU5DJ Strong Biomarker [155]
OGN OTKP5S4L Strong Biomarker [156]
PDLIM3 OTVXQC81 Strong Altered Expression [23]
PDSS1 OTXGVHAB Strong Biomarker [157]
PHACTR1 OTAMPX9V Strong Genetic Variation [158]
PIK3C2G OTW3LY1C Strong Biomarker [128]
PLA2G10 OTRZ2L5A Strong Biomarker [159]
PLEK OTB73XXA Strong Biomarker [160]
PRKAA1 OT7TNF0L Strong Altered Expression [41]
PRKAA2 OTU1KZPV Strong Altered Expression [41]
PRKAB1 OT1OG4QZ Strong Altered Expression [41]
PROP1 OT8GF6N8 Strong Genetic Variation [161]
RAB8A OTPB54Y3 Strong Genetic Variation [162]
RAPGEF5 OT53VS75 Strong Biomarker [163]
RBM8A OT5SR6G0 Strong Biomarker [164]
THSD7A OT7249HH Strong Biomarker [165]
TM4SF1 OTY0ECQN Strong Biomarker [116]
TOX3 OTC9NR4W Strong Genetic Variation [88]
DEFA3 OTO3N8E1 Definitive Biomarker [166]
PPBP OT1FHGQS Definitive Biomarker [166]
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⏷ Show the Full List of 96 DOT(s)

References

1 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 205945.
2 Postprandial Hyperlipidemia: Its Pathophysiology, Diagnosis, Atherogenesis, and Treatments. Int J Mol Sci. 2023 Sep 11;24(18):13942.
3 Cholecalciferol FDA Label
4 Cholestyramine FDA Label
5 Colestipol FDA Label
6 Ezetimibe FDA Label
7 Fenofibrate FDA Label
8 Levothyroxine FDA Label
9 Lovastatin FDA Label
10 Pemafibrate: First Global Approval. Drugs. 2017 Oct;77(16):1805-1810.
11 Probucol FDA Label
12 Simvastatin FDA Label
13 Topiramate FDA Label
14 Vitamin B3. 2024 Feb 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 JanC.
15 ClinicalTrials.gov (NCT00519714) A Study to Evaluate the Lipid Regulating Effects of 1-Methylnicotinamide (1-MNA). U.S. National Institutes of Health.
16 ClinicalTrials.gov (NCT05537571) A Multi-centre, Randomised, Double-blind, Placebo-controlled, Phase 2 Study to Investigate Efficacy, Safety and Tolerability of SLN360 in Participants With Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events. U.S.National Institutes of Health.
17 Effects of serum lipoproteins on cyclosporine A cellular uptake and renal toxicity in vitro.Can J Physiol Pharmacol. 2014 Feb;92(2):140-8. doi: 10.1139/cjpp-2013-0250.
18 The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects.Biochim Biophys Acta. 2004 Jun 1;1682(1-3):56-62. doi: 10.1016/j.bbalip.2004.01.008.
19 Neuroprotective effects of pretreatment with quercetin as assessed by acetylcholinesterase assay and behavioral testing in poloxamer-407 induced hyperlipidemic rats.Biomed Pharmacother. 2017 Apr;88:1054-1063. doi: 10.1016/j.biopha.2017.01.134. Epub 2017 Feb 7.
20 Angiopoietin-like protein 3 markedly enhanced in the hyperlipidemia related proteinuria.Lipids Health Dis. 2019 May 18;18(1):116. doi: 10.1186/s12944-019-1052-1.
21 Experimental therapies targeting apolipoprotein C-III for the treatment of hyperlipidemia - spotlight on volanesorsen.Expert Opin Investig Drugs. 2019 Apr;28(4):389-394. doi: 10.1080/13543784.2019.1582028. Epub 2019 Feb 15.
22 RIRS in the elderly: Is it feasible and safe?.Int J Surg. 2017 Jun;42:147-151. doi: 10.1016/j.ijsu.2017.04.062. Epub 2017 May 3.
23 Anti-hyperlipidemic and antioxidant effects of alkali-extractable mycelia polysaccharides by Pleurotus eryngii var. tuolensis.Carbohydr Polym. 2017 Nov 1;175:282-292. doi: 10.1016/j.carbpol.2017.08.009. Epub 2017 Aug 3.
24 Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice.J Lipid Res. 2020 Mar;61(3):365-375. doi: 10.1194/jlr.RA119000419. Epub 2019 Dec 16.
25 The metabolic ER stress sensor IRE1 suppresses alternative activation of macrophages and impairs energy expenditure in obesity.Nat Immunol. 2017 May;18(5):519-529. doi: 10.1038/ni.3709. Epub 2017 Mar 27.
26 Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats--role of vitamin K-dependent clotting factors and prevention by low-intensity oral anticoagulation.Thromb Haemost. 2001 Dec;86(6):1440-8.
27 Evaluation of potential inhibitors of squalene synthase based on virtual screening and in vitro studies.Comput Biol Chem. 2019 Jun;80:390-397. doi: 10.1016/j.compbiolchem.2019.04.008. Epub 2019 Apr 29.
28 The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis.J Immunol. 2019 Nov 15;203(10):2689-2700. doi: 10.4049/jimmunol.1900366. Epub 2019 Oct 4.
29 Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS.Biochimie. 2019 Apr;159:23-35. doi: 10.1016/j.biochi.2018.11.017. Epub 2018 Dec 1.
30 Increased expression and activity of 11beta-HSD-1 in diabetic islets and prevention with troglitazone.Biochem Biophys Res Commun. 2004 Jan 16;313(3):594-9. doi: 10.1016/j.bbrc.2003.11.160.
31 Lysosomal acid lipase deficiency in all siblings of the same parents.J Clin Lipidol. 2017 Mar-Apr;11(2):567-574. doi: 10.1016/j.jacl.2017.02.006. Epub 2017 Feb 22.
32 Natural Prenylchalconaringenins and Prenylnaringenins as Antidiabetic Agents: -Glucosidase and -Amylase Inhibition and in Vivo Antihyperglycemic and Antihyperlipidemic Effects.J Agric Food Chem. 2017 Mar 1;65(8):1574-1581. doi: 10.1021/acs.jafc.6b05445. Epub 2017 Feb 17.
33 Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice.Mol Pharmacol. 2019 Jul;96(1):47-55. doi: 10.1124/mol.119.115840. Epub 2019 May 7.
34 Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids.Cell Rep. 2019 Jan 2;26(1):222-235.e5. doi: 10.1016/j.celrep.2018.12.028.
35 Proprotein convertase subtilisin/kexin 9 inhibitors in reducing cardiovascular outcomes: a systematic review and meta-analysis.Heart. 2019 Aug;105(15):1149-1159. doi: 10.1136/heartjnl-2019-314763. Epub 2019 Mar 6.
36 Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2707-13. doi: 10.1161/ATVBAHA.107.155739. Epub 2007 Oct 11.
37 Adenovirus-mediated hepatic syndecan-1 overexpression induces hepatocyte proliferation and hyperlipidaemia in mice.Liver Int. 2007 May;27(4):569-81. doi: 10.1111/j.1478-3231.2007.01442.x.
38 Development of hyperfibrinogenemia in spontaneously hypertensive and hyperlipidemic rats: a potentially useful animal model as a complication of hypertension and hyperlipidemia.Exp Anim. 2007 Jan;56(1):1-10. doi: 10.1538/expanim.56.1.
39 Flavonoids extracted from Linaria vulgaris protect against hyperlipidemia and hepatic steatosis induced by western-type diet in mice.Arch Pharm Res. 2018 Dec;41(12):1190-1198. doi: 10.1007/s12272-017-0941-y. Epub 2017 Aug 2.
40 Sortilin promotes macrophage cholesterol accumulation and aortic atherosclerosis through lysosomal degradation of ATP-binding cassette transporter A1 protein.Acta Biochim Biophys Sin (Shanghai). 2019 May 23;51(5):471-483. doi: 10.1093/abbs/gmz029.
41 Gamma-glutamyl carboxylated Gas6 mediates the beneficial effect of vitamin K on lowering hyperlipidemia via regulating the AMPK/SREBP1/PPAR signaling cascade of lipid metabolism.J Nutr Biochem. 2019 Aug;70:174-184. doi: 10.1016/j.jnutbio.2019.05.006. Epub 2019 May 25.
42 Associations of the ABCA1 and LPL Gene Polymorphisms With Lipid Levels in a Hyperlipidemic Population.Clin Appl Thromb Hemost. 2018 Jul;24(5):771-779. doi: 10.1177/1076029617725601. Epub 2017 Sep 11.
43 Predict value of adiponectin for coronary atherosclerosis plaques according to computed tomography angiography in an asymptomatic population.Clin Imaging. 2018 Sep-Oct;51:174-179. doi: 10.1016/j.clinimag.2018.05.019. Epub 2018 May 25.
44 Effects of LEP G2548A and LEPR Q223R Polymorphisms on Serum Lipids and Response to Simvastatin Treatment in Chinese Patients With Primary Hyperlipidemia.Clin Appl Thromb Hemost. 2017 May;23(4):336-344. doi: 10.1177/1076029616638504. Epub 2016 Mar 16.
45 A wild-type mouse-based model for the regression of inflammation in atherosclerosis.PLoS One. 2017 Mar 14;12(3):e0173975. doi: 10.1371/journal.pone.0173975. eCollection 2017.
46 Reduction of serum lipids by soy protein and soluble fiber is not associated with the ABCG5/G8, apolipoprotein E, and apolipoprotein A1 polymorphisms in a group of hyperlipidemic Mexican subjects.Nutr Res. 2009 Oct;29(10):728-35. doi: 10.1016/j.nutres.2009.09.013.
47 Targeting ATP-Citrate Lyase in Hyperlipidemia and Metabolic Disorders.Trends Mol Med. 2017 Nov;23(11):1047-1063. doi: 10.1016/j.molmed.2017.09.001. Epub 2017 Oct 6.
48 ADRB2 polymorphisms and dyslipidemia risk in Chinese hypertensive patients.Clin Exp Hypertens. 2017;39(2):139-144. doi: 10.1080/10641963.2016.1210625. Epub 2017 Mar 1.
49 Association of serum uric acid levels with the incident of kidney disease and rapid eGFR decline in Chinese individuals with eGFR??0mL/min/1.73m(2) and negative proteinuria.Clin Exp Nephrol. 2019 Jul;23(7):871-879. doi: 10.1007/s10157-019-01705-w. Epub 2019 Feb 8.
50 The chemical profiling of loquat leaf extract by HPLC-DAD-ESI-MS and its effects on hyperlipidemia and hyperglycemia in rats induced by a high-fat and fructose diet.Food Funct. 2017 Feb 22;8(2):687-694. doi: 10.1039/c6fo01578f.
51 Paradoxical exacerbation of combined hyperlipidemia in human apolipoprotein A-II transgenic mice treated with fenofibrate.Biochim Biophys Acta. 2005 Dec 15;1737(2-3):130-7. doi: 10.1016/j.bbalip.2005.09.009. Epub 2005 Sep 30.
52 Genetic polymorphisms of the apolipoprotein A-IV in a Greek population and their relation to plasma lipid and lipoprotein levels.Clin Genet. 2002 Sep;62(3):208-13. doi: 10.1034/j.1399-0004.2002.620304.x.
53 A novel mutation in USF1 gene is associated with familial combined hyperlipidemia.IUBMB Life. 2020 Apr;72(4):616-623. doi: 10.1002/iub.2186. Epub 2019 Nov 14.
54 An optimized dose of raspberry ketones controls hyperlipidemia and insulin resistance in male obese rats: Effect on adipose tissue expression of adipocytokines and Aquaporin 7.Eur J Pharmacol. 2018 Aug 5;832:81-89. doi: 10.1016/j.ejphar.2018.05.028. Epub 2018 May 19.
55 Acute hypoxic preconditioning prevents palmitic acid-induced cardiomyocyte apoptosis via switching metabolic GLUT4-glucose pathway back to CD36-fatty acid dependent.J Cell Biochem. 2018 Apr;119(4):3363-3372. doi: 10.1002/jcb.26501. Epub 2018 Jan 15.
56 Global inactivation of carboxylesterase 1 (Ces1/Ces1g) protects against atherosclerosis in Ldlr (-/-) mice.Sci Rep. 2017 Dec 19;7(1):17845. doi: 10.1038/s41598-017-18232-x.
57 Carboxypeptidase E mediates palmitate-induced beta-cell ER stress and apoptosis.Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8452-7. doi: 10.1073/pnas.0711232105. Epub 2008 Jun 11.
58 Higher chlorzoxazone clearance in obese children compared with nonobese peers.Br J Clin Pharmacol. 2018 Aug;84(8):1738-1747. doi: 10.1111/bcp.13602. Epub 2018 Jun 3.
59 Mechanistic Characterization of Long Residence Time Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2).Biochemistry. 2018 Dec 26;57(51):6997-7010. doi: 10.1021/acs.biochem.8b01096. Epub 2018 Dec 7.
60 Association of L-FABP T94A and MTP I128T polymorphisms with hyperlipidemia in Chinese subjects.Lipids. 2015 Mar;50(3):275-82. doi: 10.1007/s11745-015-3990-3. Epub 2015 Feb 7.
61 Suggested clinical approach for the diagnosis and management of 'statin intolerance' with an emphasis on muscle-related side-effects.Intern Med J. 2019 Sep;49(9):1081-1091. doi: 10.1111/imj.14429.
62 Low potentiality of angiotensin-converting enzyme gene insertion/deletion polymorphism as a useful predictive marker for carotid atherogenesis in a large general population of a Japanese city: the Suita study.Stroke. 2001 Jun;32(6):1250-6. doi: 10.1161/01.str.32.6.1250.
63 A common mutation of the insulin receptor substrate-1 gene is a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol. 1999 Dec;19(12):2975-80. doi: 10.1161/01.atv.19.12.2975.
64 Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues.Cell Rep. 2019 Mar 5;26(10):2738-2752.e4. doi: 10.1016/j.celrep.2019.02.014.
65 Effects of oral selenium and magnesium co-supplementation on lipid metabolism, antioxidative status, histopathological lesions, and related gene expression in rats fed a high-fat diet.Lipids Health Dis. 2018 Jul 21;17(1):165. doi: 10.1186/s12944-018-0815-4.
66 Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis.Circ Res. 2020 Jan 31;126(3):298-314. doi: 10.1161/CIRCRESAHA.119.315644. Epub 2019 Dec 9.
67 Association of lipoprotein(a) level with short- and long-term outcomes after CABG: The role of lipoprotein apheresis.Atheroscler Suppl. 2017 Nov;30:187-192. doi: 10.1016/j.atherosclerosissup.2017.05.011. Epub 2017 May 31.
68 Energy restriction, exercise and atorvastatin treatment improve endothelial dysfunction and inhibit miRNA-155 in the erectile tissue of the aged rat.Nutr Metab (Lond). 2018 Apr 16;15:28. doi: 10.1186/s12986-018-0265-z. eCollection 2018.
69 Oleanolic Acid Inhibits Liver X Receptor Alpha and Pregnane X Receptor to Attenuate Ligand-Induced Lipogenesis.J Agric Food Chem. 2018 Oct 24;66(42):10964-10976. doi: 10.1021/acs.jafc.8b03372. Epub 2018 Oct 15.
70 Double bond configuration of palmitoleate is critical for atheroprotection.Mol Metab. 2019 Oct;28:58-72. doi: 10.1016/j.molmet.2019.08.004. Epub 2019 Aug 7.
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