Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5ZAS6)

• Drug Name: Pyrrolidine dithiocarbamate Drug Info
• Synonyms: Pyrrolidine dithiocarbamate; Pyrrolidine-1-carbodithioic acid; Pyrrolidine dithiocarbamic acid; Pyrrolidinedithiocarbamate; 1-Pyrrolidinecarbodithioic acid; 25769-03-3; PDTC; apdc; Tetramethylenedithiocarbamic acid; Pyrrolidine-N-carbodithioic acid; Ammonium pyrrolidine dithiocarbamate; 1-Pyrrolidinecarbodithioic acid, ammonium salt; CHEBI:78782; Ammonium 1-pyrrolidinecarbodithioate; C5H9NS2; 5108-96-3; NSC298194; Pyrrolidine-N-dithiocarbamic acid ammonium salt; ammonium tetramethylene dithiocarbamate; NCIOpen2_000025

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 65351
  ChEBI ID: CHEBI:78782
  CAS Number: CAS 25769-03-3
  TTD Drug ID: DM5ZAS6

Molecule-Related Drug Atlas

Drug(s) Targeting Nuclear factor NF-kappa-B (NFKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[11]
Triptolide	DMCMDVR	Autoimmune diabetes	5A10	Phase 3	[12]
Laquinimod	DM3IWS8	Lupus	4A40	Phase 3	[13]
Edasalonexent	DMYVBF6	Duchenne dystrophy	8C70	Phase 3	[14]
MD1003	DMVZ57G	Multiple sclerosis	8A40	Phase 3	[14]
Vadimezan	DMK7CYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[15]
CAT 1004	DMQBP7R	Duchenne dystrophy	8C70	Phase 2	[16]
Parthenolide	DMCQBFT	N. A.	N. A.	Phase 2	[17]
Recoflavone	DMCSR8I	Inflammatory bowel disease	DD72	Phase 2	[18]
CZEN-002	DMUDMHA	Fungal infection	1F29-1F2F	Phase 2	[19]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[23]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[24]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[29]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[30]
Haloperidol	DM96SE0	Delirium		Approved	[31]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[35]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[45]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[48]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[49]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[56]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[45]

Drug(s) Affected By Metallothionein-1B (MT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[58]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[60]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]

Drug(s) Affected By U1 small nuclear ribonucleoprotein 70 kDa (SNRNP70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[73]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[76]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[85]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[89]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[71]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[91]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[92]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[45]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[97]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[99]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[101]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[104]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[105]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[26]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[108]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[111]

Drug(s) Affected By Contactin-associated protein 1 (CNTNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[114]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[118]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[43]

Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 1 (CPSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[127]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[22]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[128]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[133]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[135]

Drug(s) Affected By Serine/threonine-protein phosphatase 1 regulatory subunit 10 (PPP1R10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[2]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[143]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[144]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[145]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[146]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[152]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[153]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[156]

Drug(s) Affected By tRNA wybutosine-synthesizing protein 4 (LCMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[157]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[160]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[66]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[26]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[164]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[173]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[177]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[178]
Fructose	DM43AN2	Vomiting	MD90	Approved	[31]
Ketoprofen	DMRKXPT	Bursitis		Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[180]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[181]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[182]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[134]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[199]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[187]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[202]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[203]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[205]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[206]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Fructose	DM43AN2	Vomiting	MD90	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[210]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[215]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[222]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[223]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[202]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[131]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Selenium	DM25CGV	N. A.	N. A.	Approved	[224]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[225]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[228]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[230]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[231]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[232]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[233]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[180]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[21]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[184]
Selenium	DM25CGV	N. A.	N. A.	Approved	[215]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[236]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[238]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[239]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[240]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[243]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[84]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[31]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[247]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[251]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[233]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[254]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[150]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[255]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[257]

Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[259]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[261]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[261]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[261]

Drug(s) Affected By Macrophage-stimulating protein receptor (MST1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[263]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[264]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[265]

Drug(s) Affected By TERF1-interacting nuclear factor 2 (TINF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[110]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[267]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[267]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[267]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[268]

Drug(s) Affected By Klotho (KL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[270]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[271]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[272]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[273]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[273]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[273]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[273]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[274]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[97]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[277]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nuclear factor NF-kappa-B (NFKB)	TTSXVID	NFKB1_HUMAN; NFKB2_HUMAN; TF65_HUMAN; RELB_HUMAN; REL_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[2]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Post-Translational Modifications	[4]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[5]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Gene/Protein Processing	[6]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Drug Response	[7]
Ceruloplasmin (CP)	OTM8JE4Y	CERU_HUMAN	Gene/Protein Processing	[8]
Cleavage and polyadenylation specificity factor subunit 1 (CPSF1)	OTAU1KOM	CPSF1_HUMAN	Gene/Protein Processing	[9]
Contactin-associated protein 1 (CNTNAP1)	OT5Y03EU	CNTP1_HUMAN	Gene/Protein Processing	[9]
Copper-transporting ATPase 1 (ATP7A)	OTMR3GXP	ATP7A_HUMAN	Gene/Protein Processing	[10]

References

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• [2] Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
• [3] Tomatidine inhibits invasion of human lung adenocarcinoma cell A549 by reducing matrix metalloproteinases expression. Chem Biol Interact. 2013 May 25;203(3):580-7. doi: 10.1016/j.cbi.2013.03.016. Epub 2013 Apr 6.
• [4] Antioxidants induce different phenotypes by a distinct modulation of signal transduction. FEBS Lett. 2002 Dec 18;532(3):289-94. doi: 10.1016/s0014-5793(02)03683-9.
• [5] APE1/Ref-1 redox-specific inhibition decreases survivin protein levels and induces cell cycle arrest in prostate cancer cells. Oncotarget. 2017 Dec 13;9(13):10962-10977. doi: 10.18632/oncotarget.23493. eCollection 2018 Feb 16.
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• [10] Cytotoxic effects of pyrrolidine dithiocarbamate in small-cell lung cancer cells, alone and in combination with cisplatin. Int J Oncol. 2014 Oct;45(4):1749-59. doi: 10.3892/ijo.2014.2564. Epub 2014 Jul 28.
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• [12] Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells. Oncogene. 2001 Nov 29;20(55):8009-18.
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• [20] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
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