Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMW9CH2)

• Drug Name: Tetramethylbutylphenol Drug Info
• Synonyms: P-T-Octylphenol; Phenol, p-(tert-octyl)-; p-Octylphenol (VAN); p-Terc.oktylfenol; p-terc.Oktylfenol [Czech]; p-tert-Octylphenol; para-tert-Octylphenol; 4-(1,1,3,3-Tetramethylbutyl)phenol; tert-Octylphenol, flaked; 140-66-9; 4-(1,1,3,3-TETRAMETHYLBUTYL)PHENOL; 4-(2,4,4-trimethylpentan-2-yl)phenol; 4-(TERT-OCTYL)PHENOL; 4-t-Octylphenol; 4-tert-Octylphenol; BRN 0513992; EINECS 205-426-2; HSDB 5411; NSC 5427; Phenol, 4-(1,1,3,3-tetramethylbutyl)-; Phenol, p-(1,1,3,3-tetramethylbutyl)-; IOY9FVU3J3; UNII-IOY9FVU3J3; p-(1,1,3,3-Tetramethylbutyl)phenol
• Cross-matching ID:
  PubChem CID: 8814
  ChEBI ID: CHEBI:34445
  CAS Number: CAS 140-66-9
  TTD Drug ID: DMW9CH2
  INTEDE Drug ID: DR1983

Molecule-Related Drug Atlas

Drug(s) Metabolized By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1]
Abiraterone acetate	DMANBZI	Prostate cancer	2C82.0	Approved	[8]
Vonoprazan	DMO6315	Helicobacter infection	DA42-DA63	Approved	[9]
Pregnenolone	DM6VFO1	Schizophrenia	6A20	Phase 4	[10]
ASP-015K	DMZ1UOI	Psoriasis vulgaris	EA90	Phase 3	[11]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1]
BCP-13498	DM2BO9W	N. A.	N. A.	Phase 2	[12]
daidzein	DMRFTJX	Discovery agent	N.A.	Investigative	[1]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1]
N-nonylphenol	DMH3OUX	N. A.	N. A.	Investigative	[1]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[22]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[24]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[32]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[36]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[37]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[43]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[44]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[46]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[47]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[52]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[53]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[47]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[57]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[61]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[70]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[72]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[75]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[76]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[77]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[79]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Fructose	DM43AN2	Vomiting	MD90	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[85]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[50]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[70]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[96]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[111]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[113]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[114]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[114]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[114]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[115]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[117]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[120]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[121]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[122]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[125]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[107]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[128]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[141]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[148]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[150]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[151]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[107]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[164]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[168]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[169]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[170]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[171]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[172]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[167]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[176]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[177]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[168]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[169]

Drug(s) Affected By Retinoic acid receptor RXR-beta (RXRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[28]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[181]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[183]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[184]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[185]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[184]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[186]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[189]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[190]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[191]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[192]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[193]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[25]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[204]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[206]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[211]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[206]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[218]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[219]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]

Drug(s) Affected By Estrogen-related receptor gamma (ESRRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[223]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[224]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[225]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[226]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[232]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[236]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[239]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[240]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[241]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[243]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[64]
Mestranol	DMG3F94	Contraception	QA21	Approved	[243]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[31]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[246]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[247]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[248]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[249]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[251]
Mestranol	DMG3F94	Contraception	QA21	Approved	[252]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[253]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[223]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[206]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[61]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[257]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[258]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[259]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[260]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[262]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[265]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[266]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[268]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[269]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[270]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[271]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[272]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[273]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[272]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[268]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[83]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[267]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[272]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[269]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[271]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[275]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[272]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[276]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[269]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[272]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfotransferase 2A1 (SULT2A1) Main DME	DE0P6LK	ST2A1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[2]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Gene/Protein Processing	[3]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Gene/Protein Processing	[4]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Gene/Protein Processing	[4]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Post-Translational Modifications	[5]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Post-Translational Modifications	[5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[6]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Post-Translational Modifications	[5]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Drug Response	[7]

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