Details of Disease

General Information of Disease (ID: DIS0XS2C)

Disease Name	Age-related macular degeneration
Synonyms	age related macular degeneration; Senile macular retinal degeneration; age related maculopathy; ARMD; age-related macular degeneration; macular degeneration, age-related; age related Maculopathies; AMD; Senile macular degeneration
Disease Class	9B75: Macular degeneration
Definition	Age-related loss of vision in the central portion of the retina (macula), secondary to retinal degeneration.
Disease Hierarchy	DISBIA4H: Degeneration of macula and posterior pole DISGGL77: Inherited retinal dystrophy DIS0XS2C: Age-related macular degeneration
ICD Code	ICD-11 ICD-11: 9B75.0 ICD-10 ICD-10: H35 Expand ICD-11 9B78.3 Expand ICD-10 H35 Expand ICD-9 140,141,142,143,144,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000,000.00
Disease Identifiers	MONDO ID MONDO_0005150 MESH ID D008268 UMLS CUI C0242383 MedGen ID 116576 Orphanet ID 279 SNOMED CT ID 267718000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Eculizumab	DMJGWZ7	Approved	Monoclonal antibody	[1]
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This Disease is Treated as An Indication in 15 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Emixustat	DMH8VMP	Phase 2/3	Small molecular drug	[2]
ALK-001	DMDXZ6O	Phase 2	NA	[3]
AVA-101	DMASRP3	Phase 2	NA	[4]
CAI orotate	DMPH04W	Phase 2	NA	[5]
OT551	DMHKIOF	Phase 2	Small interfering RNA	[6]
P-144	DMH81SR	Phase 2	NA	[7]
PF-4523655	DM3YIKR	Phase 2	siRNA drug	[8]
Tesidolumab	DMR4YEG	Phase 2	Antibody	[9]
X-82	DMW1NKO	Phase 2	NA	[10]
AG-013958	DMRET3H	Phase 1/2	NA	[11]
Anti-Factor D	DM8ENKS	Phase 1/2	Antibody	[12]
NT-503	DMIKQZA	Phase 1/2	NA	[13]
AAV-sFLT gene therapy	DMZ0E69	Phase 1	NA	[14]
ACE-041	DMUBYFM	Phase 1	Small molecular drug	[15]
ASP7317	DMU7RVH	Phase 1	Cell therapy	[16]
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⏷ Show the Full List of 15 Drug(s)

This Disease is Treated as An Indication in 1 Patented Agent(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
PMID28621580-Compound-WO2015089220C70	DMX96FI	Patented	Small molecular drug	[17]
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This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
RN6G	DM5P1KQ	Discontinued in Phase 2	NA	[18]
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This Disease is Treated as An Indication in 13 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AMD-AAV7	DMPMKQV	Investigative	NA	[7]
CD59 gene therapy	DMDEXNR	Investigative	NA	[7]
EPI-0031	DMTUSKA	Investigative	NA	[7]
HTRA-1 mabs	DML677O	Investigative	Monoclonal antibody	[7]
L-19-PDT	DMMC6LA	Investigative	NA	[7]
MN-2011	DMP9QSE	Investigative	NA	[7]
Modified vitamin A	DMR5NWV	Investigative	NA	[7]
NM-9308	DMC89HI	Investigative	Antibody	[19]
NT-502	DM1UNKA	Investigative	NA	[7]
OcuXan	DMSX3WA	Investigative	NA	[7]
RNA-144101	DMTQ0MD	Investigative	NA	[7]
SHEF-1	DMMZTN3	Investigative	NA	[7]
SMT-D004	DMTTXIA	Investigative	NA	[7]
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⏷ Show the Full List of 13 Drug(s)

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 82 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
C3	TTJGY7A	Limited	Biomarker	[20]
CD59	TTBGTEJ	Limited	Biomarker	[21]
CDH3	TTARMD9	Limited	Genetic Variation	[22]
FNDC1	TTQJCV8	Limited	Biomarker	[23]
LAMP2	TTULDG7	Limited	Biomarker	[24]
MME	TT5TKPM	Limited	Biomarker	[25]
PGF	TT48I1Y	Limited	Altered Expression	[26]
PROM1	TTXMZ81	Limited	Genetic Variation	[27]
RPGR	TTHBDA9	Limited	Biomarker	[28]
RS1	TTT2CZY	Limited	Genetic Variation	[29]
SQSTM1	TTOT2RY	Limited	Biomarker	[30]
ALDH5A1	TTJUWVB	moderate	Biomarker	[31]
C3AR1	TTI6B3F	moderate	Biomarker	[32]
CACNA1C	TTZIFHC	moderate	Biomarker	[31]
CASP5	TTWR48J	moderate	Altered Expression	[33]
CD46	TTMS7DF	moderate	Altered Expression	[34]
CNGB3	TT0LJCG	moderate	Biomarker	[35]
CNTF	TTGEM5Q	moderate	Biomarker	[36]
DDIT4	TTVEOY6	moderate	Genetic Variation	[37]
E2F2	TT5FYX0	moderate	Biomarker	[38]
FECH	TTQ6VF4	moderate	Altered Expression	[39]
FPR1	TT5Y4EM	moderate	Genetic Variation	[40]
GCLM	TTNFESW	moderate	Biomarker	[41]
HDAC11	TT8K17W	moderate	Biomarker	[42]
LTB4R	TTN53ZF	moderate	Biomarker	[43]
METAP2	TTZL0OI	moderate	Biomarker	[44]
MFGE8	TT1GLAJ	moderate	Genetic Variation	[45]
PLTP	TTZF6SN	moderate	Biomarker	[46]
RHO	TTH0KSX	moderate	Genetic Variation	[47]
SLC11A2	TT2IS7P	moderate	Genetic Variation	[48]
TEC	TT1ZV49	moderate	Biomarker	[49]
TEP1	TTQGAVX	moderate	Altered Expression	[50]
TSPAN7	TTMT6VE	moderate	Biomarker	[51]
ABCG1	TTMWDGU	Strong	Biomarker	[52]
ACAT1	TTK3C21	Strong	Altered Expression	[53]
AIF1	TT12MEP	Strong	Biomarker	[54]
AMD1	TTBFROQ	Strong	Biomarker	[55]
ANG	TTURHFP	Strong	Altered Expression	[56]
AOC3	TT7HC21	Strong	Biomarker	[57]
CA13	TTQPHSR	Strong	Biomarker	[58]
CCR3	TTD3XFU	Strong	Biomarker	[59]
CD55	TT5Z9WY	Strong	Genetic Variation	[60]
CETP	TTFQAYR	Strong	Genetic Variation	[61]
CFD	TT8D13I	Strong	Biomarker	[62]
COL18A1	TT63DI9	Strong	Altered Expression	[56]
CRYAB	TT7RUHB	Strong	Biomarker	[63]
CRYBB1	TTDS503	Strong	Biomarker	[64]
CX3CL1	TT1OFBQ	Strong	Biomarker	[65]
CXCR5	TTIW59R	Strong	Genetic Variation	[66]
CYP21A2	TTP4GLG	Strong	Genetic Variation	[67]
FABP5	TTNT2S6	Strong	Biomarker	[68]
FHL1	TTI7ENL	Strong	Genetic Variation	[69]
FLT1	TT1VAUK	Strong	Genetic Variation	[70]
GALNS	TTT9YPO	Strong	Genetic Variation	[71]
GAS6	TT69QD2	Strong	Biomarker	[72]
GAST	TT4LRVO	Strong	Genetic Variation	[71]
GRK5	TTTCXO0	Strong	Genetic Variation	[73]
HMOX2	TTWZRL4	Strong	Genetic Variation	[74]
IMPDH1	TT3GRLK	Strong	Genetic Variation	[75]
KCNT2	TTLU5FO	Strong	Genetic Variation	[76]
KIR2DS1	TTVWAGF	Strong	Biomarker	[77]
KIR3DL2	TTQH3N0	Strong	Biomarker	[77]
LAMP1	TTC214J	Strong	Biomarker	[78]
LRP6	TTSXOWE	Strong	Altered Expression	[79]
MAN2B1	TTC12RO	Strong	Altered Expression	[80]
MAP4K1	TTSHWUP	Strong	Biomarker	[81]
MUTYH	TTNB0ZK	Strong	Genetic Variation	[82]
P2RX7	TT473XN	Strong	Biomarker	[83]
PDE5A	TTJ0IQB	Strong	Biomarker	[84]
RENBP	TTZCG0Q	Strong	Biomarker	[85]
RORA	TT1TYN7	Strong	Genetic Variation	[86]
SERPINF1	TTR59S1	Strong	Altered Expression	[87]
SRPK2	TTCZEJ9	Strong	Genetic Variation	[76]
SUCNR1	TT4FX9Y	Strong	Altered Expression	[88]
TF	TT8WXAV	Strong	Genetic Variation	[89]
TGFBR1	TTP4520	Strong	Genetic Variation	[90]
TMEM97	TT9NXW4	Strong	Genetic Variation	[76]
TRPM1	TTTDAI9	Strong	Genetic Variation	[91]
TRPM3	TTO3TD8	Strong	Genetic Variation	[76]
TST	TT51OTS	Strong	Genetic Variation	[92]
APOB	TTN1IE2	Definitive	Altered Expression	[53]
CD36	TTPJMCU	Definitive	Biomarker	[93]
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⏷ Show the Full List of 82 DTT(s)

This Disease Is Related to 3 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
CACNG3	DTVFLQD	Limited	Genetic Variation	[94]
ABCA7	DTDVSJA	moderate	Genetic Variation	[95]
SLC16A8	DT39AOM	moderate	Biomarker	[96]
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This Disease Is Related to 10 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
NMNAT1	DE4D159	Limited	Biomarker	[97]
BCO1	DE6BOK3	moderate	Genetic Variation	[98]
CYP2R1	DEBIHM3	moderate	Genetic Variation	[99]
UGT2B17	DEAZDL8	moderate	Biomarker	[100]
ALDH1A2	DEKN1H4	Strong	Genetic Variation	[76]
CYP27A1	DEBS639	Strong	Genetic Variation	[101]
EPHX1	DELB4KP	Strong	Genetic Variation	[102]
MGST1	DEAPJSO	Strong	Biomarker	[103]
MT2A	DEFKGT7	Strong	Genetic Variation	[104]
RDH5	DESI4OK	Strong	Genetic Variation	[76]
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⏷ Show the Full List of 10 DME(s)

This Disease Is Related to 157 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ARIH2	OTJYJQJ8	Limited	Biomarker	[105]
BHLHE22	OTZUQY5L	Limited	Altered Expression	[106]
C2	OTHMF4YM	Limited	Genetic Variation	[107]
CFHR2	OTACE5Y1	Limited	Genetic Variation	[108]
CP	OTM8JE4Y	Limited	Biomarker	[109]
ECM1	OT1K65VW	Limited	Genetic Variation	[110]
EYS	OT0NBPL5	Limited	Genetic Variation	[28]
HIC1	OTI9TWY4	Limited	Biomarker	[111]
HSPH1	OTVRR73T	Limited	Biomarker	[112]
HYLS1	OT3SW5UC	Limited	Biomarker	[113]
LOXL1	OTA0NEJU	Limited	Genetic Variation	[114]
NOP56	OTT67SRZ	Limited	Posttranslational Modification	[115]
PARP12	OTCQTYIO	Limited	Biomarker	[111]
PLCG2	OTGVC9MY	Limited	Biomarker	[116]
TDRD9	OTS4UBI8	Limited	Biomarker	[113]
ACAT2	OTZ092ZJ	moderate	Altered Expression	[53]
ACO1	OT2VUR7L	moderate	Genetic Variation	[117]
ADIPOR2	OT2HDTL8	moderate	Biomarker	[118]
ARNT	OTMSIEZY	moderate	Genetic Variation	[119]
BBX	OTNQ3QUC	moderate	Genetic Variation	[120]
C4A	OTXMOYXU	moderate	Genetic Variation	[121]
C9	OT7I5FDX	moderate	Genetic Variation	[122]
CD5L	OTPY4WQR	moderate	Biomarker	[123]
CD93	OT6HZT6H	moderate	Altered Expression	[124]
CDH7	OTQEXCKU	moderate	Genetic Variation	[125]
CFHR1	OT72R16T	moderate	Genetic Variation	[90]
CFHR3	OTYL8SDO	moderate	Biomarker	[126]
CFHR4	OTWXGQMU	moderate	Genetic Variation	[127]
CGRRF1	OTLMNRCL	moderate	Genetic Variation	[128]
CHMP2B	OTZA7RJB	moderate	Genetic Variation	[48]
CRB1	OTXYUNG0	moderate	Genetic Variation	[129]
CTRB2	OTR9TOBV	moderate	Genetic Variation	[67]
CXCL6	OTFTCQ4O	moderate	Biomarker	[130]
DLGAP1	OTF2PUUI	moderate	Genetic Variation	[128]
DMRT1	OT5PU9U1	moderate	Genetic Variation	[48]
EDF1	OTL07TLS	moderate	Altered Expression	[131]
FBN2	OT3KYJQL	moderate	Genetic Variation	[132]
FGD6	OTI0T62C	moderate	Genetic Variation	[133]
FILIP1L	OTPY8IMS	moderate	Genetic Variation	[120]
HEPH	OTZ2F15Z	moderate	Biomarker	[134]
HGS	OTCYYCAC	moderate	Genetic Variation	[95]
IL27RA	OTSQBAKI	moderate	Biomarker	[135]
IMPG2	OTFPSJ0T	moderate	Biomarker	[136]
ITM2B	OTMXEPXB	moderate	Altered Expression	[137]
KIDINS220	OTLBH2MA	moderate	Genetic Variation	[138]
LAMA3	OTFME7HT	moderate	Biomarker	[139]
LRRTM4	OTYJ4348	moderate	Genetic Variation	[140]
MASP1	OTWWCNZP	moderate	Biomarker	[46]
MFSD8	OT455EIC	moderate	Genetic Variation	[141]
MIA3	OTBVIZQD	moderate	Genetic Variation	[119]
MMP20	OT16S5S3	moderate	Biomarker	[142]
MYO7A	OTBZSPEL	moderate	Altered Expression	[143]
MYOG	OTPLJKFA	moderate	Biomarker	[144]
NPHP1	OTZHCFFQ	moderate	Biomarker	[145]
NR2E3	OTO3GBHQ	moderate	Biomarker	[146]
P4HTM	OTKELL7F	moderate	Biomarker	[147]
PCDHGA12	OT3JJI7L	moderate	Biomarker	[53]
PELI3	OTCBUSKJ	moderate	Genetic Variation	[148]
PEX1	OTQJF0V7	moderate	Genetic Variation	[149]
PRPF31	OTSJ0Z1Y	moderate	Genetic Variation	[150]
PRSS50	OTC5JAVO	moderate	Genetic Variation	[151]
RDH8	OTSFFV9B	moderate	Biomarker	[152]
RFC2	OTJ9N6BD	moderate	Biomarker	[153]
SCD5	OTSSUQ3Z	moderate	Biomarker	[154]
SEMA3E	OTD4S36H	moderate	Biomarker	[155]
SERPINB8	OT5T4Y5R	moderate	Genetic Variation	[125]
SRL	OT7IEBWZ	moderate	Biomarker	[156]
SRM	OT4N5MDP	moderate	Biomarker	[157]
TLR10	OTQ1KVJO	moderate	Altered Expression	[158]
TRA2B	OTZYQW52	moderate	Biomarker	[159]
TSHZ1	OTYQ9ECW	moderate	Genetic Variation	[160]
ABHD2	OTCRUOCS	Strong	Genetic Variation	[91]
ACAD10	OTFAG3M0	Strong	Genetic Variation	[161]
AGBL4	OTOX2H61	Strong	Genetic Variation	[162]
ARHGAP21	OT6XY8Y9	Strong	Genetic Variation	[76]
ATP6V0D1	OT9GU2NW	Strong	Genetic Variation	[67]
ATXN7	OTL3YF1H	Strong	Altered Expression	[163]
BBS9	OT23V9YF	Strong	Genetic Variation	[67]
C1QTNF5	OTLKU5I2	Strong	Genetic Variation	[164]
CAPN5	OTQ8QM7K	Strong	Biomarker	[165]
CDHR1	OT1ORXCM	Strong	Biomarker	[166]
CIAO3	OT0V91PK	Strong	Altered Expression	[167]
CLUL1	OTYIXQ36	Strong	Genetic Variation	[168]
CNN2	OTH3CSXA	Strong	Genetic Variation	[76]
COL10A1	OTC4G2YC	Strong	Genetic Variation	[169]
COL4A3	OT6SB8X5	Strong	Genetic Variation	[76]
COL8A1	OTWBTED2	Strong	Genetic Variation	[170]
CRX	OTH435SV	Strong	Biomarker	[28]
CRYBB2	OTL0Z8E6	Strong	Biomarker	[64]
CST3	OTNZ6AO4	Strong	Genetic Variation	[171]
CTNNA1	OTFC725Z	Strong	Genetic Variation	[172]
CTRB1	OTFFF738	Strong	Biomarker	[67]
DAPL1	OTQZZSZY	Strong	Altered Expression	[173]
DCP1B	OTX7PHCI	Strong	Genetic Variation	[103]
DIAPH2	OTBEYFEZ	Strong	Biomarker	[174]
DPF3	OTEWLMNB	Strong	Genetic Variation	[67]
ERCC2	OT1C8HQ4	Strong	Genetic Variation	[175]
ERCC6	OT2QZKSF	Strong	Genetic Variation	[175]
FMOD	OT9EJ5H8	Strong	Biomarker	[176]
FRK	OTEKV1SC	Strong	Biomarker	[177]
FSCN2	OTADS8G3	Strong	Genetic Variation	[178]
FTCD	OTX9HZT5	Strong	Genetic Variation	[179]
FTMT	OTIUX6XG	Strong	Altered Expression	[180]
FUT6	OTBZUQ7F	Strong	Genetic Variation	[76]
GDF6	OTERXWJU	Strong	Biomarker	[181]
GEMIN2	OT4L6TLL	Strong	Altered Expression	[182]
GNB3	OTA6HYBA	Strong	Biomarker	[183]
GNGT2	OTRI3Q10	Strong	Genetic Variation	[183]
GSTM5	OTMMBFY8	Strong	Biomarker	[184]
HERC1	OT73FVYZ	Strong	Genetic Variation	[67]
HS3ST4	OTO0UBFN	Strong	Genetic Variation	[67]
IL17RC	OTEFOBSS	Strong	Biomarker	[185]
IL2RG	OTRZ3OMY	Strong	Genetic Variation	[183]
IMPG1	OT12HBL0	Strong	Genetic Variation	[186]
MAP2	OT6UYT3X	Strong	Genetic Variation	[187]
MARK4	OT6Z2TGV	Strong	Genetic Variation	[76]
MCUB	OTXLLSIZ	Strong	Genetic Variation	[169]
MFRP	OTHY9ZA5	Strong	Genetic Variation	[188]
MYOM2	OTD2UOXW	Strong	Genetic Variation	[189]
MYRIP	OTH2TFYH	Strong	Biomarker	[190]
ND2	OTG9OHOX	Strong	Genetic Variation	[91]
NECTIN2	OTIE0W6O	Strong	Genetic Variation	[108]
NELFE	OTL4E94L	Strong	Genetic Variation	[125]
NPLOC4	OTC1WUVF	Strong	Genetic Variation	[76]
NT5DC1	OTNI9MFH	Strong	Genetic Variation	[169]
OCA2	OTDWIGBF	Strong	Biomarker	[191]
OPTC	OTCASGO0	Strong	Genetic Variation	[192]
OSBP2	OTDGLB4J	Strong	Biomarker	[193]
OTX2	OTTV05B1	Strong	Biomarker	[194]
PAGR1	OTXR5PQ8	Strong	Genetic Variation	[71]
PBX2	OTEBYCAW	Strong	Genetic Variation	[76]
PEA15	OTKCKTSX	Strong	Biomarker	[191]
PILRA	OTBE0PLF	Strong	Genetic Variation	[76]
PITPNM3	OTHLZY8D	Strong	Biomarker	[195]
PLA2G12A	OTHHCQ17	Strong	Genetic Variation	[196]
PLEK	OTB73XXA	Strong	Genetic Variation	[197]
PLXNA2	OTNNBJMQ	Strong	Biomarker	[198]
PNPLA2	OTR3ERMR	Strong	Biomarker	[199]
PROK1	OT8S7RUG	Strong	Biomarker	[81]
PRPH2	OTNH2G5H	Strong	Biomarker	[200]
PTX3	OTPXHRKU	Strong	Altered Expression	[201]
RAD51B	OTCJVRMY	Strong	Biomarker	[96]
RGR	OTKCF5AZ	Strong	Biomarker	[202]
RGS10	OTQ8N1QH	Strong	Genetic Variation	[203]
RLBP1	OTCY4D6B	Strong	Biomarker	[111]
ROM1	OTE7H0YV	Strong	Biomarker	[204]
RREB1	OT62460U	Strong	Genetic Variation	[205]
SCAF11	OTX59D0X	Strong	Altered Expression	[182]
SCAPER	OT7S3B3P	Strong	Genetic Variation	[206]
SGCD	OTRBL3NQ	Strong	Genetic Variation	[207]
SLURP1	OT89YD2E	Strong	Genetic Variation	[208]
STK19	OTYM6437	Strong	Genetic Variation	[76]
SUCLA2	OTMZD4PW	Strong	Biomarker	[209]
SYN3	OTSGYNA5	Strong	Genetic Variation	[76]
TFR2	OTMYCCEO	Strong	Genetic Variation	[210]
TNMD	OTHLVA9G	Strong	Genetic Variation	[211]
PRPH	OT6VUH78	Definitive	Genetic Variation	[212]
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⏷ Show the Full List of 157 DOT(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6884).
2	ClinicalTrials.gov (NCT01802866) Safety and Efficacy Assessment Treatment Trials of Emixustat Hydrochloride. U.S. National Institutes of Health.
3	ClinicalTrials.gov (NCT02402660) Tolerability and Effects of ALK-001 on Stargardt Disease. U.S. National Institutes of Health.
4	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800035470)
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800032169)
6	ClinicalTrials.gov (NCT00306488) OT-551 Antioxidant Eye Drops to Treat Geographic Atrophy in Age-Related Macular Degeneration. U.S. National Institutes of Health.
7	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
8	2011 Pipeline of Quark Pharm.
9	ClinicalTrials.gov (NCT01527500) Intravitreal LFG316 in Patients With Age-related Macular Degeneration (AMD). U.S. National Institutes of Health.
10	ClinicalTrials.gov (NCT02348359) X-82 to Treat Age-related Macular Degeneration. U.S. National Institutes of Health.
11	ClinicalTrials.gov (NCT00090532) A Study Of The Safety And Efficacy Of AG-013,958 In Subjects With Subfoveal Choroidal Neovascularization Associated With Age-Related Macular Degeneration. U.S. National Institutes of Health.
12	Clinical pipeline report, company report or official report of Genentech (2011).
13	ClinicalTrials.gov (NCT02228304) Study of the Intravitreal Implantation of NT-503-3 Encapsulated Cell Technology (ECT) for the Treatment of Recurrent Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD). U.S. National Institutes of Health.
14	ClinicalTrials.gov (NCT00229736) A Study of AAV-hAADC-2 in Subjects With Parkinson's Disease. U.S. National Institutes of Health.
15	Clinical pipeline report, company report or official report of Acceleron Pharma (2011).
16	ClinicalTrials.gov (NCT03178149) A Study of the Safety and Tolerability of ASP7317 in Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration. U.S. National Institutes of Health.
17	VEGFR-2 inhibitors and the therapeutic applications thereof: a patent review (2012-2016).Expert Opin Ther Pat. 2017 Sep;27(9):987-1004.
18	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031573)
19	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2339).
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