Details of the Drug Combination

General Information of Drug Combination (ID: DC0SYTI)

Drug Combination Name
Menthol Mannitol
Indication
Disease Entry Status REF
Diabetic Peripheral Neuropathy Phase 1 [1]
Component Drugs Menthol   DMG2KW7 Mannitol   DMSCDY9
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Menthol
Disease Entry ICD 11 Status REF
Back pain ME84.Z Approved [2]
Pityriasis simplex N.A. Approved [2]
Throat irritation CA0Y Approved [3]
Tinea versicolor 1F2D.0 Approved [2]
Pruritus EC90 Investigative [2]
Menthol Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Long transient receptor potential channel 8 (TRPM8) TTXDKTO TRPM8_HUMAN Activator [9]
Transformation-sensitive protein p120 (TRPA1) TTELV3W TRPA1_HUMAN Activator [9]
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Menthol Interacts with 341 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Transient receptor potential cation channel subfamily M member 8 (TRPM8) OT7ACGYK TRPM8_HUMAN Decreases Response To Substance [10]
Deoxyribonuclease-2-alpha (DNASE2) OT6RC1BL DNS2A_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Increases Expression [6]
E3 SUMO-protein ligase CBX4 (CBX4) OT4XVRRF CBX4_HUMAN Increases Expression [6]
DNA fragmentation factor subunit alpha (DFFA) OTFPFMT8 DFFA_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Decreases Expression [6]
Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4) OTYAI1UO CACB4_HUMAN Decreases Expression [6]
TNF receptor-associated factor 5 (TRAF5) OTSBTLO0 TRAF5_HUMAN Decreases Expression [6]
Transcription factor E2F3 (E2F3) OT5VQMWY E2F3_HUMAN Decreases Expression [6]
Etoposide-induced protein 2.4 homolog (EI24) OTD4NOYS EI24_HUMAN Decreases Expression [6]
Prostaglandin E synthase (PTGES) OTB7YQFU PTGES_HUMAN Decreases Expression [6]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Increases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) OT1Q40TZ MP2K7_HUMAN Decreases Expression [6]
Programmed cell death protein 5 (PDCD5) OT6T2DDL PDCD5_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Decreases Expression [6]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C) OTVHOL9B TR10C_HUMAN Decreases Expression [6]
Calpain-9 (CAPN9) OTE4IU5U CAN9_HUMAN Decreases Expression [6]
Protein Mdm4 (MDM4) OTU10BSF MDM4_HUMAN Increases Expression [6]
Phospholipid scramblase 1 (PLSCR1) OTGY9B5T PLS1_HUMAN Decreases Expression [6]
Tumor protein p73 (TP73) OT0LUO47 P73_HUMAN Decreases Expression [6]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Increases Expression [6]
Proline dehydrogenase 1, mitochondrial (PRODH) OT7SQ1C7 PROD_HUMAN Increases Expression [6]
Death-associated protein kinase 3 (DAPK3) OTLV7EKW DAPK3_HUMAN Decreases Expression [6]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2) OT0KMIYQ RIPK2_HUMAN Increases Expression [6]
Glutamate receptor ionotropic, delta-2 (GRID2) OTJ3R10R GRID2_HUMAN Increases Expression [6]
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G) OTGKBRE4 CAC1G_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 12 (TNFSF12) OT6FQ02V TNF12_HUMAN Decreases Expression [6]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) OT5QRF09 TNF14_HUMAN Decreases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Decreases Expression [6]
Neuropilin-2 (NRP2) OTZL256E NRP2_HUMAN Decreases Expression [6]
Lipid transferase CIDEA (CIDEA) OTDUTSOV CIDEA_HUMAN Increases Expression [6]
Immunoglobulin mu Fc receptor (FCMR) OTI7I47T FCMR_HUMAN Increases Expression [6]
Polyglutamine-binding protein 1 (PQBP1) OTXCBEAH PQBP1_HUMAN Increases Expression [6]
Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F) OTQTXNGF CAC1F_HUMAN Increases Expression [6]
Nucleolar protein 3 (NOL3) OT1K0L0D NOL3_HUMAN Increases Expression [6]
Programmed cell death protein 6 (PDCD6) OT2YA5M8 PDCD6_HUMAN Decreases Expression [6]
Nucleoside diphosphate kinase 6 (NME6) OTJNKOFA NDK6_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21) OT3EDGXO TNR21_HUMAN Decreases Expression [6]
Syntaxin-11 (STX11) OTHFRSFP STX11_HUMAN Decreases Expression [6]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) OT90OWIO TNF13_HUMAN Decreases Expression [6]
DNA fragmentation factor subunit beta (DFFB) OTPBW5N5 DFFB_HUMAN Increases Expression [6]
Signal recognition particle subunit SRP72 (SRP72) OTPV73W7 SRP72_HUMAN Decreases Expression [6]
Serine/threonine-protein kinase 17B (STK17B) OT4NYNO8 ST17B_HUMAN Decreases Expression [6]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5) OTL0S21W PKHG5_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Decreases Expression [6]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H) OTM705TH CAC1H_HUMAN Decreases Expression [6]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Increases Expression [6]
CUGBP Elav-like family member 2 (CELF2) OTLJJ4VT CELF2_HUMAN Increases Expression [6]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8) OT1G9297 TFIP8_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) OTKAN9G7 TNF6B_HUMAN Decreases Expression [6]
BAG family molecular chaperone regulator 4 (BAG4) OTUPX3M2 BAG4_HUMAN Increases Expression [6]
Tyrosyl-DNA phosphodiesterase 2 (TDP2) OT1K0UMV TYDP2_HUMAN Increases Expression [6]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1) OT4TMERS NFAC1_HUMAN Increases Expression [6]
BAG family molecular chaperone regulator 2 (BAG2) OTI6LD27 BAG2_HUMAN Decreases Expression [6]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [6]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Decreases Expression [6]
B-cell lymphoma/leukemia 10 (BCL10) OT47MCLI BCL10_HUMAN Decreases Expression [6]
Superoxide dismutase (SOD1) OT39TA1L SODC_HUMAN Increases Expression [6]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [6]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Expression [6]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [6]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Decreases Expression [6]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [6]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) OTBPMIMW G3P_HUMAN Increases Expression [6]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [6]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [6]
Amyloid-beta precursor protein (APP) OTKFD7R4 A4_HUMAN Decreases Expression [6]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [6]
Gelsolin (GSN) OT4KS2UU GELS_HUMAN Decreases Expression [6]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Expression [6]
Calpain-1 catalytic subunit (CAPN1) OTK6OQZR CAN1_HUMAN Increases Expression [6]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 16 (NGFR) OTPKSM49 TNR16_HUMAN Increases Expression [6]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Decreases Expression [6]
Cytochrome c1, heme protein, mitochondrial (CYC1) OT0962IM CY1_HUMAN Decreases Expression [6]
Interleukin-3 (IL3) OT0CQ35N IL3_HUMAN Decreases Expression [6]
Annexin A5 (ANXA5) OTZS877V ANXA5_HUMAN Increases Expression [6]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Increases Expression [6]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Decreases Expression [6]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [6]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Decreases Expression [6]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Decreases Expression [6]
Interferon regulatory factor 1 (IRF1) OT43DI6J IRF1_HUMAN Decreases Expression [6]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [6]
DNA topoisomerase 1 (TOP1) OT51O0CF TOP1_HUMAN Decreases Expression [6]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Increases Expression [6]
Cation-independent mannose-6-phosphate receptor (IGF2R) OTDXPQVX MPRI_HUMAN Increases Expression [6]
ADP/ATP translocase 1 (SLC25A4) OTKYLK2J ADT1_HUMAN Decreases Expression [6]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [6]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [6]
Endoplasmin (HSP90B1) OT02XLBR ENPL_HUMAN Decreases Expression [6]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [6]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Increases Expression [6]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Increases Expression [6]
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2) OT1C8HQ4 ERCC2_HUMAN Increases Expression [6]
Large ribosomal subunit protein uL30 (RPL7) OT4WCQBE RL7_HUMAN Increases Expression [6]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) OTVAW3P1 ERCC3_HUMAN Increases Expression [6]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) OTDS2EAR TNR1B_HUMAN Increases Expression [6]
Lamin-B1 (LMNB1) OT100T3P LMNB1_HUMAN Increases Expression [6]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Increases Expression [6]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Decreases Expression [6]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Decreases Expression [6]
Cadherin-3 (CDH3) OTKNLQU7 CADH3_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase CBL (CBL) OTTKELCU CBL_HUMAN Decreases Expression [6]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Decreases Expression [6]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) OTOCBX7P TNFL4_HUMAN Increases Expression [6]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Decreases Expression [6]
Insulin-like growth factor-binding protein 6 (IGFBP6) OTW878VI IBP6_HUMAN Increases Expression [6]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [6]
Deoxyribonuclease-1 (DNASE1) OTM4KWB3 DNAS1_HUMAN Decreases Expression [6]
Adenomatous polyposis coli protein (APC) OTKV0TIK APC_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [6]
Proteasome subunit alpha type-3 (PSMA3) OT52M10V PSA3_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [6]
Elongation factor 1-gamma (EEF1G) OTW7DH2F EF1G_HUMAN Decreases Expression [6]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [6]
Proteasome subunit alpha type-5 (PSMA5) OT38E6Y1 PSA5_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) OTJ8UM8O TNR8_HUMAN Decreases Expression [6]
DNA-3-methyladenine glycosylase (MPG) OTAHW80B 3MG_HUMAN Decreases Expression [6]
AT-rich interactive domain-containing protein 4A (ARID4A) OT1XKBZ0 ARI4A_HUMAN Increases Expression [6]
Lysine-specific demethylase 5A (KDM5A) OTLYFX8A KDM5A_HUMAN Decreases Expression [6]
Caspase-1 (CASP1) OTZ3YQFU CASP1_HUMAN Decreases Expression [6]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Increases Expression [6]
Protein PML (PML) OT6SM2GD PML_HUMAN Decreases Expression [6]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [6]
Peroxiredoxin-5, mitochondrial (PRDX5) OTUEKZ18 PRDX5_HUMAN Decreases Expression [6]
Translocator protein (TSPO) OTSU7ESK TSPO_HUMAN Decreases Expression [6]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Expression [6]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Expression [6]
Caspase-14 (CASP14) OTKY93H9 CASPE_HUMAN Increases Expression [6]
CD70 antigen (CD70) OTHB2AL1 CD70_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 8 (TNFSF8) OTDYGDJ3 TNFL8_HUMAN Decreases Expression [6]
Cannabinoid receptor 2 (CNR2) OTYP9P43 CNR2_HUMAN Decreases Expression [6]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Decreases Expression [6]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Increases Expression [6]
Vascular endothelial growth factor receptor 2 (KDR) OT15797V VGFR2_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 3 (LTBR) OT2HVZGV TNR3_HUMAN Increases Expression [6]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Decreases Expression [6]
Nuclear pore glycoprotein p62 (NUP62) OTMN63DH NUP62_HUMAN Decreases Expression [6]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [6]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9) OTV9L89D TNFL9_HUMAN Increases Expression [6]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [6]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Decreases Expression [6]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [6]
Huntingtin (HTT) OTKN8P85 HD_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) OTDK74C0 TNR4_HUMAN Decreases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) OTZPZX11 MP2K4_HUMAN Increases Expression [6]
Small ribosomal subunit protein uS4 (RPS9) OTPV69Q0 RS9_HUMAN Decreases Expression [6]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [6]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Expression [6]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Decreases Expression [6]
Type-2 angiotensin II receptor (AGTR2) OTU8GU9M AGTR2_HUMAN Decreases Expression [6]
Serpin B9 (SERPINB9) OTJ811IF SPB9_HUMAN Increases Expression [6]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [6]
Death-associated protein 1 (DAP) OT5YLL7E DAP1_HUMAN Decreases Expression [6]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Decreases Expression [6]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [6]
Caspase-5 (CASP5) OT0F2THD CASP5_HUMAN Decreases Expression [6]
Cyclin-G1 (CCNG1) OT17IA9L CCNG1_HUMAN Decreases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [6]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase 10 (MAPK10) OTC46VX1 MK10_HUMAN Decreases Expression [6]
UV excision repair protein RAD23 homolog B (RAD23B) OT0PGOG3 RD23B_HUMAN Decreases Expression [6]
Epithelial membrane protein 3 (EMP3) OTODMJ1D EMP3_HUMAN Increases Expression [6]
Allograft inflammatory factor 1 (AIF1) OTGES18F AIF1_HUMAN Increases Expression [6]
Exportin-2 (CSE1L) OTV2X99A XPO2_HUMAN Increases Expression [6]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Expression [6]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Expression [6]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) OT2TTZPZ CDN2D_HUMAN Decreases Expression [6]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Expression [6]
Nucleoside diphosphate kinase homolog 5 (NME5) OTE8OLFN NDK5_HUMAN Decreases Expression [6]
Caspase recruitment domain-containing protein 18 (CARD18) OTBMLB80 CAR18_HUMAN Decreases Expression [6]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [6]
Interleukin-2 (IL2) OTGI4NSA IL2_HUMAN Increases Expression [6]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS10 (RPS20) OTI8052R RS20_HUMAN Increases Expression [6]
Small ribosomal subunit protein eS1 (RPS3A) OTUEP7CL RS3A_HUMAN Increases Expression [6]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Decreases Expression [6]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1) OTUUNQBT DAD1_HUMAN Decreases Expression [6]
Large ribosomal subunit protein eL31 (RPL31) OTV9E1OE RL31_HUMAN Decreases Expression [6]
Growth factor receptor-bound protein 2 (GRB2) OTOP7LTE GRB2_HUMAN Decreases Expression [6]
Elongation factor 1-alpha 1 (EEF1A1) OT00THXS EF1A1_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2) OTEO98CR IF4G2_HUMAN Decreases Expression [6]
T-complex protein 1 subunit beta (CCT2) OTW1VV4E TCPB_HUMAN Decreases Expression [6]
Glutathione S-transferase omega-1 (GSTO1) OTUJ93MN GSTO1_HUMAN Increases Expression [6]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Increases Expression [6]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6) OT1SLUZH TSG6_HUMAN Decreases Expression [6]
Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B) OTRM0XDW CAC1B_HUMAN Decreases Expression [6]
Protein BEX3 (BEX3) OTW1V1L5 BEX3_HUMAN Increases Expression [6]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B) OT9NPJCR PDE1B_HUMAN Decreases Expression [6]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [6]
Nucleolysin TIAR (TIAL1) OTV2KFZH TIAR_HUMAN Decreases Expression [6]
Transcription factor E2F1 (E2F1) OTLKYBBC E2F1_HUMAN Increases Expression [6]
Forkhead box protein K2 (FOXK2) OTFXDZ3R FOXK2_HUMAN Increases Expression [6]
Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D) OTQFH2ZD CAC1D_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17) OT1YFEP1 TNR17_HUMAN Increases Expression [6]
Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1) OTV42SIT CACB1_HUMAN Decreases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1) OT4Y9NQI MP2K1_HUMAN Decreases Expression [6]
DNA topoisomerase 2-beta (TOP2B) OTDHKQZ8 TOP2B_HUMAN Increases Expression [6]
Caveolin-1 (CAV1) OTEZUR1L CAV1_HUMAN Increases Expression [6]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2) OTRZH80H TNAP2_HUMAN Increases Expression [6]
Lactoylglutathione lyase (GLO1) OTXFS5B3 LGUL_HUMAN Increases Expression [6]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Expression [6]
Peroxiredoxin-1 (PRDX1) OTZ3BEC4 PRDX1_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9) OTNOM26L TNR9_HUMAN Increases Expression [6]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Decreases Expression [6]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Expression [6]
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2) OT53K8W2 CACB2_HUMAN Decreases Expression [6]
Lactadherin (MFGE8) OTQKE41R MFGM_HUMAN Increases Expression [6]
Retinoblastoma-like protein 2 (RBL2) OTBQSOE6 RBL2_HUMAN Decreases Expression [6]
Histone acetyltransferase p300 (EP300) OTL8QJDX EP300_HUMAN Decreases Expression [6]
Sterol regulatory element-binding protein 2 (SREBF2) OTBXUNPL SRBP2_HUMAN Decreases Expression [6]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13) OTESFZSO PTN13_HUMAN Increases Expression [6]
TNF receptor-associated factor 2 (TRAF2) OT1MEZZN TRAF2_HUMAN Decreases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) OTVZD4H6 BNIP2_HUMAN Increases Expression [6]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Decreases Expression [6]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Decreases Expression [6]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Increases Expression [6]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Decreases Expression [6]
TNF receptor-associated factor 3 (TRAF3) OT5TQBGV TRAF3_HUMAN Increases Expression [6]
FAS-associated death domain protein (FADD) OTV7GFHH FADD_HUMAN Decreases Expression [6]
Serine/threonine-protein kinase PAK 2 (PAK2) OTLUNCIH PAK2_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase CBL-B (CBLB) OTPLRER9 CBLB_HUMAN Decreases Expression [6]
Nucleoside diphosphate kinase 3 (NME3) OT0CA0GF NDK3_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) OTS3FVTY M3K1_HUMAN Increases Expression [6]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 5 activator 2 (CDK5R2) OTNUTLPU CD5R2_HUMAN Increases Expression [6]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Expression [6]
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2) OTK5T6HZ NFAC2_HUMAN Increases Expression [6]
GRB2-associated-binding protein 1 (GAB1) OTQKE6V4 GAB1_HUMAN Increases Expression [6]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Decreases Expression [6]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Increases Expression [6]
Deoxyribonuclease gamma (DNASE1L3) OTEUIMC2 DNSL3_HUMAN Increases Expression [6]
Apoptosis-stimulating of p53 protein 2 (TP53BP2) OTOWJ2Y4 ASPP2_HUMAN Increases Expression [6]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1) OT6VY3A3 SPTN1_HUMAN Decreases Expression [6]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1) OT37EWR0 BACD2_HUMAN Decreases Expression [6]
Cyclin-dependent kinase 13 (CDK13) OT3P7JF1 CDK13_HUMAN Increases Expression [6]
Pro-interleukin-16 (IL16) OTZ2MO6B IL16_HUMAN Decreases Expression [6]
Dedicator of cytokinesis protein 1 (DOCK1) OTCFV3ON DOCK1_HUMAN Decreases Expression [6]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [6]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [6]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [6]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Increases Expression [6]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Decreases Expression [6]
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) OTV7ZA9O NMDE3_HUMAN Decreases Expression [6]
Nuclear mitotic apparatus protein 1 (NUMA1) OTTKAVG4 NUMA1_HUMAN Increases Expression [6]
Protein disulfide-isomerase A6 (PDIA6) OT8YBR17 PDIA6_HUMAN Increases Expression [6]
Retinoblastoma-binding protein 5 (RBBP5) OT12W2MK RBBP5_HUMAN Decreases Expression [6]
Transcription factor E2F5 (E2F5) OT1XWING E2F5_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD) OTBOSJHO TRADD_HUMAN Increases Expression [6]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E) OTHATMLU CAC1E_HUMAN Decreases Expression [6]
Programmed cell death protein 2 (PDCD2) OTUOGSDJ PDCD2_HUMAN Decreases Expression [6]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [6]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [6]
Serine/threonine-protein kinase LMTK1 (AATK) OTVHAX5N LMTK1_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase RBBP6 (RBBP6) OTTVG4HU RBBP6_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase SIAH1 (SIAH1) OT29A838 SIAH1_HUMAN Decreases Expression [6]
Secreted frizzled-related protein 1 (SFRP1) OT0U9G41 SFRP1_HUMAN Increases Expression [6]
TRAF3-interacting protein 1 (TRAF3IP1) OTLCC64B MIPT3_HUMAN Decreases Expression [6]
MAP kinase-activating death domain protein (MADD) OTUFYVGG MADD_HUMAN Increases Expression [6]
Unconventional myosin-XVIIIa (MYO18A) OT2YPT7O MY18A_HUMAN Increases Expression [6]
Protein FAN (NSMAF) OTYNVZ23 FAN_HUMAN Increases Expression [6]
Zinc finger protein ubi-d4 (DPF2) OTL0JH2C REQU_HUMAN Decreases Expression [6]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [6]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Decreases Expression [6]
Caspase-10 (CASP10) OTE6J88E CASPA_HUMAN Increases Expression [6]
Bcl2-associated agonist of cell death (BAD) OT63ERYM BAD_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14) OTB82PFO TNR14_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) OTVZ7I3A TNR25_HUMAN Decreases Expression [6]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3) OTFYDEES AT2A3_HUMAN Increases Expression [6]
Modulator of apoptosis 1 (MOAP1) OTVF3LUG MOAP1_HUMAN Decreases Expression [6]
PRKC apoptosis WT1 regulator protein (PAWR) OTKY7W52 PAWR_HUMAN Increases Expression [6]
Bcl-2-modifying factor (BMF) OT90NSLI BMF_HUMAN Decreases Expression [6]
Parkinson disease protein 7 (PARK7) OT0SKNTG PARK7_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) OTT3DOOL M3K14_HUMAN Increases Expression [6]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF) OTT5JX1F LITAF_HUMAN Increases Expression [6]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3) OT53LJGW M3K3_HUMAN Decreases Expression [6]
BAG family molecular chaperone regulator 1 (BAG1) OTRQNIA4 BAG1_HUMAN Decreases Expression [6]
B-cell CLL/lymphoma 7 protein family member B (BCL7B) OT8DQQRD BCL7B_HUMAN Increases Expression [6]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) OTJP4U7K HNRL1_HUMAN Increases Expression [6]
Oxidoreductase HTATIP2 (HTATIP2) OT9MZ4QO HTAI2_HUMAN Increases Expression [6]
TNF receptor-associated factor 4 (TRAF4) OTJLRVMC TRAF4_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase TRAIP (TRAIP) OTMPT9Y2 TRAIP_HUMAN Decreases Expression [6]
Caspase recruitment domain-containing protein 10 (CARD10) OT2RPM4I CAR10_HUMAN Decreases Expression [6]
Caspase recruitment domain-containing protein 6 (CARD6) OTEI1PJ1 CARD6_HUMAN Decreases Expression [6]
Caspase recruitment domain-containing protein 14 (CARD14) OTADQHOV CAR14_HUMAN Decreases Expression [6]
Caspase recruitment domain-containing protein 11 (CARD11) OTRCTLYC CAR11_HUMAN Decreases Expression [6]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14) OT87E7HW B2L14_HUMAN Increases Expression [6]
NACHT, LRR and PYD domains-containing protein 1 (NLRP1) OT4BNNOS NLRP1_HUMAN Increases Expression [6]
Autophagy protein 5 (ATG5) OT4T5SMS ATG5_HUMAN Increases Expression [6]
Caspase recruitment domain-containing protein 9 (CARD9) OTJ81AWD CARD9_HUMAN Increases Expression [6]
Bcl-2-like protein 12 (BCL2L12) OTS6IFZY B2L12_HUMAN Decreases Expression [6]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) OTPGYWKC NOD2_HUMAN Increases Expression [6]
p53-regulated apoptosis-inducing protein 1 (TP53AIP1) OT1XVNDP TPIP1_HUMAN Decreases Expression [6]
Bcl-2-like protein 10 (BCL2L10) OTYXQJ3I B2L10_HUMAN Increases Expression [6]
NLR family CARD domain-containing protein 4 (NLRC4) OTAIA3NA NLRC4_HUMAN Decreases Expression [6]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [6]
Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2) OTFJXVQQ CA2D2_HUMAN Decreases Expression [6]
Bifunctional apoptosis regulator (BFAR) OTTBG0V7 BFAR_HUMAN Decreases Expression [6]
Hematopoietic cell signal transducer (HCST) OTILCB4K HCST_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D) OTOSRDJT TR10D_HUMAN Decreases Expression [6]
Peflin (PEF1) OTY24CUW PEF1_HUMAN Increases Expression [6]
Serine/threonine-protein kinase 17A (STK17A) OTS87MOT ST17A_HUMAN Decreases Expression [6]
Death domain-associated protein 6 (DAXX) OTX6O7PL DAXX_HUMAN Decreases Expression [6]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Increases Expression [6]
NADH dehydrogenase 1 alpha subcomplex subunit 12 (NDUFA12) OTCD6I5M NDUAC_HUMAN Increases Expression [6]
Death-associated protein kinase 2 (DAPK2) OTWODUQG DAPK2_HUMAN Decreases Expression [6]
Inhibitor of growth protein 1 (ING1) OTEZBRKW ING1_HUMAN Increases Expression [6]
CASP8-associated protein 2 (CASP8AP2) OTTWT68S C8AP2_HUMAN Decreases Expression [6]
BAG family molecular chaperone regulator 5 (BAG5) OT0J97C6 BAG5_HUMAN Increases Expression [6]
Apoptosis-associated speck-like protein containing a CARD (PYCARD) OT67RON3 ASC_HUMAN Decreases Expression [6]
Calpain-11 (CAPN11) OTEHK57V CAN11_HUMAN Decreases Expression [6]
Bcl-2-related ovarian killer protein (BOK) OTDQPDIX BOK_HUMAN Decreases Expression [6]
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) OT3ANRX1 TNF18_HUMAN Increases Expression [6]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Decreases Expression [6]
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) OTUN9GUS NOD1_HUMAN Decreases Expression [6]
RAC-gamma serine/threonine-protein kinase (AKT3) OT5M2LFI AKT3_HUMAN Increases Expression [6]
Caspase recruitment domain-containing protein 8 (CARD8) OTXXZYWU CARD8_HUMAN Increases Expression [6]
TNF receptor-associated factor 6 (TRAF6) OTA5GO5K TRAF6_HUMAN Decreases Expression [6]
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) OTL1D484 RIPK3_HUMAN Increases Expression [6]
NF-kappa-B essential modulator (IKBKG) OTNWJWSD NEMO_HUMAN Decreases Expression [6]
Calpain-6 (CAPN6) OT8K5PR5 CAN6_HUMAN Decreases Expression [6]
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A) OT1FISGN TNR11_HUMAN Decreases Expression [6]
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8) OTW4A4Q0 NDUB8_HUMAN Decreases Expression [11]
Cytochrome c oxidase subunit 2 (COX2) OTTMVBJJ COX2_HUMAN Decreases Expression [11]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Secretion [12]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [13]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Secretion [12]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Expression [13]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB) OTRE1M1T SDHB_HUMAN Decreases Expression [11]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [14]
Transforming protein RhoA (RHOA) OT6YOJ9N RHOA_HUMAN Increases Expression [15]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [15]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Increases Expression [15]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Phosphorylation [12]
Transient receptor potential cation channel subfamily V member 1 (TRPV1) OTHHDR03 TRPV1_HUMAN Increases Activity [10]
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⏷ Show the Full List of 341 DOT(s)
Indication(s) of Mannitol
Disease Entry ICD 11 Status REF
Bronchiectasis CA24 Approved [4]
Cerebral edema 8D60.1 Approved [5]
Cystic fibrosis CA25 Approved [5]
Edema MG29 Approved [5]
Ocular hypertension 9C61.01 Approved [5]
Pseudotumor cerebri N.A. Approved [5]
Renal failure GB60-GB6Z Approved [4]
Mannitol Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Aspergillus Mannitol 2-dehydrogenase (Asperg M2DH) TTTX5M8 M2DH_ASPFU Activator [16]
Aspergillus Mannitol-1-phosphate 5-dehydrogenase (Asperg mpdA) TTV0PE2 MTLD_ASPFU Activator [16]
------------------------------------------------------------------------------------
Mannitol Interacts with 9 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [17]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [18]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Increases Expression [19]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [20]
Tumor protein D52 (TPD52) OTPKSK43 TPD52_HUMAN Decreases Expression [20]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Decreases Expression [20]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Increases ADR [21]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases ADR [21]
H(+)/Cl(-) exchange transporter 3 (CLCN3) OTEEXNMU CLCN3_HUMAN Affects Response To Substance [22]
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⏷ Show the Full List of 9 DOT(s)

References

1 ClinicalTrials.gov (NCT02728687) Topical Menthol +/- Mannitol for Painful Diabetic Peripheral Neuropathy
2 methyl salicylate FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2471).
4 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 016080.
5 Mannitol FDA Label
6 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
7 Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. Pharmacogenetics. 2000 Nov;10(8):679-85. doi: 10.1097/00008571-200011000-00002.
8 cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem Biophys Res Commun. 1993 Jul 15;194(1):496-503.
9 TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
10 The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017 Dec 1;336:55-65. doi: 10.1016/j.taap.2017.10.012. Epub 2017 Oct 18.
11 Pod-based menthol and tobacco flavored e-cigarettes cause mitochondrial dysfunction in lung epithelial cells. Toxicol Lett. 2020 Oct 15;333:303-311. doi: 10.1016/j.toxlet.2020.08.003. Epub 2020 Aug 9.
12 Menthol in electronic cigarettes: A contributor to respiratory disease?. Toxicol Appl Pharmacol. 2020 Nov 15;407:115238. doi: 10.1016/j.taap.2020.115238. Epub 2020 Sep 17.
13 Menthol reduces the anticoagulant effect of warfarin by inducing cytochrome P450 2C expression. Eur J Pharm Sci. 2014 Jun 2;56:92-101. doi: 10.1016/j.ejps.2014.02.011. Epub 2014 Mar 1.
14 Menthol regulates TRPM8-independent processes in PC-3 prostate cancer cells. Biochim Biophys Acta. 2009 Jan;1792(1):33-8. doi: 10.1016/j.bbadis.2008.09.012. Epub 2008 Oct 9.
15 Monoterpene regulation of Ras and Ras-related protein expression. J Lipid Res. 2003 Jun;44(6):1209-15. doi: 10.1194/jlr.M300057-JLR200. Epub 2003 Apr 1.
16 Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies o... Chem Biol Interact. 2009 Mar 16;178(1-3):274-82.
17 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
18 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
19 [Plasma levels of atrial natriuretic factor (ANF) in the stroke patients after glycerol and mannitol infusion]. Zhonghua Yi Xue Za Zhi (Taipei). 1990 Aug;46(2):86-90.
20 Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
21 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
22 Differential expression and roles of volume-activated chloride channels in control of growth of normal and cancerous nasopharyngeal epithelial cells. Biochem Pharmacol. 2012 Feb 1;83(3):324-34. doi: 10.1016/j.bcp.2011.11.007. Epub 2011 Nov 18.