Details of the Drug Combination

General Information of Drug Combination (ID: DCQBPUF)

• Drug Combination Name: Menthol + Nicotine
• Indication: Nicotine Dependence; Status: Phase 1 [1]
• Component Drugs:
  Menthol (DMG2KW7): Small molecular drug
  Nicotine (DMWX5CO): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Menthol

Disease Entry	ICD 11	Status	REF
Back pain	ME84.Z	Approved	[2]
Pityriasis simplex	N.A.	Approved	[2]
Throat irritation	CA0Y	Approved	[3]
Tinea versicolor	1F2D.0	Approved	[2]
Pruritus	EC90	Investigative	[2]

Menthol Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Long transient receptor potential channel 8 (TRPM8)	TTXDKTO	TRPM8_HUMAN	Activator	[10]
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[10]

Menthol Interacts with 341 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Transient receptor potential cation channel subfamily M member 8 (TRPM8)	OT7ACGYK	TRPM8_HUMAN	Decreases Response To Substance	[11]
Deoxyribonuclease-2-alpha (DNASE2)	OT6RC1BL	DNS2A_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)	OTBPCU2O	TR10A_HUMAN	Increases Expression	[7]
E3 SUMO-protein ligase CBX4 (CBX4)	OT4XVRRF	CBX4_HUMAN	Increases Expression	[7]
DNA fragmentation factor subunit alpha (DFFA)	OTFPFMT8	DFFA_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[7]
Voltage-dependent L-type calcium channel subunit beta-4 (CACNB4)	OTYAI1UO	CACB4_HUMAN	Decreases Expression	[7]
TNF receptor-associated factor 5 (TRAF5)	OTSBTLO0	TRAF5_HUMAN	Decreases Expression	[7]
Transcription factor E2F3 (E2F3)	OT5VQMWY	E2F3_HUMAN	Decreases Expression	[7]
Etoposide-induced protein 2.4 homolog (EI24)	OTD4NOYS	EI24_HUMAN	Decreases Expression	[7]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Decreases Expression	[7]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Increases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)	OT1Q40TZ	MP2K7_HUMAN	Decreases Expression	[7]
Programmed cell death protein 5 (PDCD5)	OT6T2DDL	PDCD5_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Decreases Expression	[7]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 10C (TNFRSF10C)	OTVHOL9B	TR10C_HUMAN	Decreases Expression	[7]
Calpain-9 (CAPN9)	OTE4IU5U	CAN9_HUMAN	Decreases Expression	[7]
Protein Mdm4 (MDM4)	OTU10BSF	MDM4_HUMAN	Increases Expression	[7]
Phospholipid scramblase 1 (PLSCR1)	OTGY9B5T	PLS1_HUMAN	Decreases Expression	[7]
Tumor protein p73 (TP73)	OT0LUO47	P73_HUMAN	Decreases Expression	[7]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Increases Expression	[7]
Proline dehydrogenase 1, mitochondrial (PRODH)	OT7SQ1C7	PROD_HUMAN	Increases Expression	[7]
Death-associated protein kinase 3 (DAPK3)	OTLV7EKW	DAPK3_HUMAN	Decreases Expression	[7]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	OT0KMIYQ	RIPK2_HUMAN	Increases Expression	[7]
Glutamate receptor ionotropic, delta-2 (GRID2)	OTJ3R10R	GRID2_HUMAN	Increases Expression	[7]
Voltage-dependent T-type calcium channel subunit alpha-1G (CACNA1G)	OTGKBRE4	CAC1G_HUMAN	Increases Expression	[7]
Tumor necrosis factor ligand superfamily member 12 (TNFSF12)	OT6FQ02V	TNF12_HUMAN	Decreases Expression	[7]
Tumor necrosis factor ligand superfamily member 14 (TNFSF14)	OT5QRF09	TNF14_HUMAN	Decreases Expression	[7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Decreases Expression	[7]
Neuropilin-2 (NRP2)	OTZL256E	NRP2_HUMAN	Decreases Expression	[7]
Lipid transferase CIDEA (CIDEA)	OTDUTSOV	CIDEA_HUMAN	Increases Expression	[7]
Immunoglobulin mu Fc receptor (FCMR)	OTI7I47T	FCMR_HUMAN	Increases Expression	[7]
Polyglutamine-binding protein 1 (PQBP1)	OTXCBEAH	PQBP1_HUMAN	Increases Expression	[7]
Voltage-dependent L-type calcium channel subunit alpha-1F (CACNA1F)	OTQTXNGF	CAC1F_HUMAN	Increases Expression	[7]
Nucleolar protein 3 (NOL3)	OT1K0L0D	NOL3_HUMAN	Increases Expression	[7]
Programmed cell death protein 6 (PDCD6)	OT2YA5M8	PDCD6_HUMAN	Decreases Expression	[7]
Nucleoside diphosphate kinase 6 (NME6)	OTJNKOFA	NDK6_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)	OT3EDGXO	TNR21_HUMAN	Decreases Expression	[7]
Syntaxin-11 (STX11)	OTHFRSFP	STX11_HUMAN	Decreases Expression	[7]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[7]
Tumor necrosis factor ligand superfamily member 13 (TNFSF13)	OT90OWIO	TNF13_HUMAN	Decreases Expression	[7]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Increases Expression	[7]
Signal recognition particle subunit SRP72 (SRP72)	OTPV73W7	SRP72_HUMAN	Decreases Expression	[7]
Serine/threonine-protein kinase 17B (STK17B)	OT4NYNO8	ST17B_HUMAN	Decreases Expression	[7]
Pleckstrin homology domain-containing family G member 5 (PLEKHG5)	OTL0S21W	PKHG5_HUMAN	Increases Expression	[7]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15)	OTNGA2BW	TNF15_HUMAN	Decreases Expression	[7]
Voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)	OTM705TH	CAC1H_HUMAN	Decreases Expression	[7]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Increases Expression	[7]
CUGBP Elav-like family member 2 (CELF2)	OTLJJ4VT	CELF2_HUMAN	Increases Expression	[7]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)	OT1G9297	TFIP8_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)	OTKAN9G7	TNF6B_HUMAN	Decreases Expression	[7]
BAG family molecular chaperone regulator 4 (BAG4)	OTUPX3M2	BAG4_HUMAN	Increases Expression	[7]
Tyrosyl-DNA phosphodiesterase 2 (TDP2)	OT1K0UMV	TYDP2_HUMAN	Increases Expression	[7]
Nuclear factor of activated T-cells, cytoplasmic 1 (NFATC1)	OT4TMERS	NFAC1_HUMAN	Increases Expression	[7]
BAG family molecular chaperone regulator 2 (BAG2)	OTI6LD27	BAG2_HUMAN	Decreases Expression	[7]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Increases Expression	[7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Decreases Expression	[7]
B-cell lymphoma/leukemia 10 (BCL10)	OT47MCLI	BCL10_HUMAN	Decreases Expression	[7]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[7]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[7]
Prelamin-A/C (LMNA)	OT3SG7ZR	LMNA_HUMAN	Increases Expression	[7]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Expression	[7]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Decreases Expression	[7]
N-myc proto-oncogene protein (MYCN)	OTWD33K1	MYCN_HUMAN	Decreases Expression	[7]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Increases Expression	[7]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[7]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[7]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Decreases Expression	[7]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[7]
Gelsolin (GSN)	OT4KS2UU	GELS_HUMAN	Decreases Expression	[7]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Increases Expression	[7]
Calpain-1 catalytic subunit (CAPN1)	OTK6OQZR	CAN1_HUMAN	Increases Expression	[7]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[7]
Heat shock protein HSP 90-beta (HSP90AB1)	OTR69EG7	HS90B_HUMAN	Decreases Expression	[7]
Cytochrome c1, heme protein, mitochondrial (CYC1)	OT0962IM	CY1_HUMAN	Decreases Expression	[7]
Interleukin-3 (IL3)	OT0CQ35N	IL3_HUMAN	Decreases Expression	[7]
Annexin A5 (ANXA5)	OTZS877V	ANXA5_HUMAN	Increases Expression	[7]
Granzyme B (GZMB)	OTPPVIRS	GRAB_HUMAN	Increases Expression	[7]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Decreases Expression	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[7]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Decreases Expression	[7]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Decreases Expression	[7]
Interferon regulatory factor 1 (IRF1)	OT43DI6J	IRF1_HUMAN	Decreases Expression	[7]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[7]
DNA topoisomerase 1 (TOP1)	OT51O0CF	TOP1_HUMAN	Decreases Expression	[7]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Increases Expression	[7]
Cation-independent mannose-6-phosphate receptor (IGF2R)	OTDXPQVX	MPRI_HUMAN	Increases Expression	[7]
ADP/ATP translocase 1 (SLC25A4)	OTKYLK2J	ADT1_HUMAN	Decreases Expression	[7]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[7]
Perforin-1 (PRF1)	OTFVXD7H	PERF_HUMAN	Decreases Expression	[7]
Endoplasmin (HSP90B1)	OT02XLBR	ENPL_HUMAN	Decreases Expression	[7]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Decreases Expression	[7]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Increases Expression	[7]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Increases Expression	[7]
General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)	OT1C8HQ4	ERCC2_HUMAN	Increases Expression	[7]
Large ribosomal subunit protein uL30 (RPL7)	OT4WCQBE	RL7_HUMAN	Increases Expression	[7]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)	OTVAW3P1	ERCC3_HUMAN	Increases Expression	[7]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)	OTDS2EAR	TNR1B_HUMAN	Increases Expression	[7]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Increases Expression	[7]
B-cell lymphoma 3 protein (BCL3)	OT1M5B95	BCL3_HUMAN	Increases Expression	[7]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Decreases Expression	[7]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Decreases Expression	[7]
Cadherin-3 (CDH3)	OTKNLQU7	CADH3_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase CBL (CBL)	OTTKELCU	CBL_HUMAN	Decreases Expression	[7]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Decreases Expression	[7]
Tumor necrosis factor ligand superfamily member 4 (TNFSF4)	OTOCBX7P	TNFL4_HUMAN	Increases Expression	[7]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[7]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Decreases Expression	[7]
Insulin-like growth factor-binding protein 6 (IGFBP6)	OTW878VI	IBP6_HUMAN	Increases Expression	[7]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[7]
Deoxyribonuclease-1 (DNASE1)	OTM4KWB3	DNAS1_HUMAN	Decreases Expression	[7]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[7]
Proteasome subunit alpha type-3 (PSMA3)	OT52M10V	PSA3_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Expression	[7]
Elongation factor 1-gamma (EEF1G)	OTW7DH2F	EF1G_HUMAN	Decreases Expression	[7]
CD27 antigen (CD27)	OTH7NA58	CD27_HUMAN	Increases Expression	[7]
Proteasome subunit alpha type-5 (PSMA5)	OT38E6Y1	PSA5_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8)	OTJ8UM8O	TNR8_HUMAN	Decreases Expression	[7]
DNA-3-methyladenine glycosylase (MPG)	OTAHW80B	3MG_HUMAN	Decreases Expression	[7]
AT-rich interactive domain-containing protein 4A (ARID4A)	OT1XKBZ0	ARI4A_HUMAN	Increases Expression	[7]
Lysine-specific demethylase 5A (KDM5A)	OTLYFX8A	KDM5A_HUMAN	Decreases Expression	[7]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Decreases Expression	[7]
Nitric oxide synthase 1 (NOS1)	OT7M8XVG	NOS1_HUMAN	Increases Expression	[7]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Decreases Expression	[7]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Expression	[7]
Peroxiredoxin-5, mitochondrial (PRDX5)	OTUEKZ18	PRDX5_HUMAN	Decreases Expression	[7]
Translocator protein (TSPO)	OTSU7ESK	TSPO_HUMAN	Decreases Expression	[7]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Expression	[7]
RAC-beta serine/threonine-protein kinase (AKT2)	OTBB632K	AKT2_HUMAN	Decreases Expression	[7]
Caspase-14 (CASP14)	OTKY93H9	CASPE_HUMAN	Increases Expression	[7]
CD70 antigen (CD70)	OTHB2AL1	CD70_HUMAN	Increases Expression	[7]
Tumor necrosis factor ligand superfamily member 8 (TNFSF8)	OTDYGDJ3	TNFL8_HUMAN	Decreases Expression	[7]
Cannabinoid receptor 2 (CNR2)	OTYP9P43	CNR2_HUMAN	Decreases Expression	[7]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Decreases Expression	[7]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)	OTTWCZYM	ALS_HUMAN	Increases Expression	[7]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 3 (LTBR)	OT2HVZGV	TNR3_HUMAN	Increases Expression	[7]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Decreases Expression	[7]
Nuclear pore glycoprotein p62 (NUP62)	OTMN63DH	NUP62_HUMAN	Decreases Expression	[7]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[7]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)	OTV9L89D	TNFL9_HUMAN	Increases Expression	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[7]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Decreases Expression	[7]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Expression	[7]
Huntingtin (HTT)	OTKN8P85	HD_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)	OTDK74C0	TNR4_HUMAN	Decreases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)	OTZPZX11	MP2K4_HUMAN	Increases Expression	[7]
Small ribosomal subunit protein uS4 (RPS9)	OTPV69Q0	RS9_HUMAN	Decreases Expression	[7]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[7]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Increases Expression	[7]
Presenilin-1 (PSEN1)	OTKL39RT	PSN1_HUMAN	Decreases Expression	[7]
Type-2 angiotensin II receptor (AGTR2)	OTU8GU9M	AGTR2_HUMAN	Decreases Expression	[7]
Serpin B9 (SERPINB9)	OTJ811IF	SPB9_HUMAN	Increases Expression	[7]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Decreases Expression	[7]
Death-associated protein 1 (DAP)	OT5YLL7E	DAP1_HUMAN	Decreases Expression	[7]
Small ribosomal subunit protein mS29 (DAP3)	OTNPEZYM	RT29_HUMAN	Decreases Expression	[7]
Tyrosine-protein kinase Blk (BLK)	OT1EB8MT	BLK_HUMAN	Decreases Expression	[7]
Caspase-5 (CASP5)	OT0F2THD	CASP5_HUMAN	Decreases Expression	[7]
Cyclin-G1 (CCNG1)	OT17IA9L	CCNG1_HUMAN	Decreases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Decreases Expression	[7]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Decreases Expression	[7]
Mitogen-activated protein kinase 10 (MAPK10)	OTC46VX1	MK10_HUMAN	Decreases Expression	[7]
UV excision repair protein RAD23 homolog B (RAD23B)	OT0PGOG3	RD23B_HUMAN	Decreases Expression	[7]
Epithelial membrane protein 3 (EMP3)	OTODMJ1D	EMP3_HUMAN	Increases Expression	[7]
Allograft inflammatory factor 1 (AIF1)	OTGES18F	AIF1_HUMAN	Increases Expression	[7]
Exportin-2 (CSE1L)	OTV2X99A	XPO2_HUMAN	Increases Expression	[7]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Expression	[7]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Expression	[7]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Decreases Expression	[7]
Cyclin-dependent kinase 4 inhibitor D (CDKN2D)	OT2TTZPZ	CDN2D_HUMAN	Decreases Expression	[7]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Expression	[7]
Nucleoside diphosphate kinase homolog 5 (NME5)	OTE8OLFN	NDK5_HUMAN	Decreases Expression	[7]
Caspase recruitment domain-containing protein 18 (CARD18)	OTBMLB80	CAR18_HUMAN	Decreases Expression	[7]
Triosephosphate isomerase (TPI1)	OT14KP4B	TPIS_HUMAN	Increases Expression	[7]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Increases Expression	[7]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[7]
Small ribosomal subunit protein uS10 (RPS20)	OTI8052R	RS20_HUMAN	Increases Expression	[7]
Small ribosomal subunit protein eS1 (RPS3A)	OTUEP7CL	RS3A_HUMAN	Increases Expression	[7]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Decreases Expression	[7]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)	OTUUNQBT	DAD1_HUMAN	Decreases Expression	[7]
Large ribosomal subunit protein eL31 (RPL31)	OTV9E1OE	RL31_HUMAN	Decreases Expression	[7]
Growth factor receptor-bound protein 2 (GRB2)	OTOP7LTE	GRB2_HUMAN	Decreases Expression	[7]
Elongation factor 1-alpha 1 (EEF1A1)	OT00THXS	EF1A1_HUMAN	Decreases Expression	[7]
Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)	OTEO98CR	IF4G2_HUMAN	Decreases Expression	[7]
T-complex protein 1 subunit beta (CCT2)	OTW1VV4E	TCPB_HUMAN	Decreases Expression	[7]
Glutathione S-transferase omega-1 (GSTO1)	OTUJ93MN	GSTO1_HUMAN	Increases Expression	[7]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)	OTTM6KRB	ADA17_HUMAN	Increases Expression	[7]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[7]
Voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)	OTRM0XDW	CAC1B_HUMAN	Decreases Expression	[7]
Protein BEX3 (BEX3)	OTW1V1L5	BEX3_HUMAN	Increases Expression	[7]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)	OT9NPJCR	PDE1B_HUMAN	Decreases Expression	[7]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1)	OTOVM4D4	SPTB2_HUMAN	Increases Expression	[7]
Nucleolysin TIAR (TIAL1)	OTV2KFZH	TIAR_HUMAN	Decreases Expression	[7]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Expression	[7]
Forkhead box protein K2 (FOXK2)	OTFXDZ3R	FOXK2_HUMAN	Increases Expression	[7]
Voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	OTQFH2ZD	CAC1D_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)	OT1YFEP1	TNR17_HUMAN	Increases Expression	[7]
Voltage-dependent L-type calcium channel subunit beta-1 (CACNB1)	OTV42SIT	CACB1_HUMAN	Decreases Expression	[7]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Decreases Expression	[7]
DNA topoisomerase 2-beta (TOP2B)	OTDHKQZ8	TOP2B_HUMAN	Increases Expression	[7]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[7]
Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)	OTRZH80H	TNAP2_HUMAN	Increases Expression	[7]
Lactoylglutathione lyase (GLO1)	OTXFS5B3	LGUL_HUMAN	Increases Expression	[7]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Expression	[7]
Peroxiredoxin-1 (PRDX1)	OTZ3BEC4	PRDX1_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)	OTNOM26L	TNR9_HUMAN	Increases Expression	[7]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Decreases Expression	[7]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Expression	[7]
Voltage-dependent L-type calcium channel subunit beta-2 (CACNB2)	OT53K8W2	CACB2_HUMAN	Decreases Expression	[7]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Increases Expression	[7]
Retinoblastoma-like protein 2 (RBL2)	OTBQSOE6	RBL2_HUMAN	Decreases Expression	[7]
Histone acetyltransferase p300 (EP300)	OTL8QJDX	EP300_HUMAN	Decreases Expression	[7]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Decreases Expression	[7]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)	OTESFZSO	PTN13_HUMAN	Increases Expression	[7]
TNF receptor-associated factor 2 (TRAF2)	OT1MEZZN	TRAF2_HUMAN	Decreases Expression	[7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2)	OTVZD4H6	BNIP2_HUMAN	Increases Expression	[7]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	OT4SO7J4	BNIP3_HUMAN	Decreases Expression	[7]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Decreases Expression	[7]
Baculoviral IAP repeat-containing protein 1 (NAIP)	OTLA925F	BIRC1_HUMAN	Increases Expression	[7]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Decreases Expression	[7]
TNF receptor-associated factor 3 (TRAF3)	OT5TQBGV	TRAF3_HUMAN	Increases Expression	[7]
FAS-associated death domain protein (FADD)	OTV7GFHH	FADD_HUMAN	Decreases Expression	[7]
Serine/threonine-protein kinase PAK 2 (PAK2)	OTLUNCIH	PAK2_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase CBL-B (CBLB)	OTPLRER9	CBLB_HUMAN	Decreases Expression	[7]
Nucleoside diphosphate kinase 3 (NME3)	OT0CA0GF	NDK3_HUMAN	Decreases Expression	[7]
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)	OTS3FVTY	M3K1_HUMAN	Increases Expression	[7]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Decreases Expression	[7]
Cyclin-dependent kinase 5 activator 2 (CDK5R2)	OTNUTLPU	CD5R2_HUMAN	Increases Expression	[7]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Increases Expression	[7]
Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)	OTK5T6HZ	NFAC2_HUMAN	Increases Expression	[7]
GRB2-associated-binding protein 1 (GAB1)	OTQKE6V4	GAB1_HUMAN	Increases Expression	[7]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[7]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)	OTC41R1E	RIPK1_HUMAN	Increases Expression	[7]
Deoxyribonuclease gamma (DNASE1L3)	OTEUIMC2	DNSL3_HUMAN	Increases Expression	[7]
Apoptosis-stimulating of p53 protein 2 (TP53BP2)	OTOWJ2Y4	ASPP2_HUMAN	Increases Expression	[7]
Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)	OT6VY3A3	SPTN1_HUMAN	Decreases Expression	[7]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 (TNFAIP1)	OT37EWR0	BACD2_HUMAN	Decreases Expression	[7]
Cyclin-dependent kinase 13 (CDK13)	OT3P7JF1	CDK13_HUMAN	Increases Expression	[7]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Decreases Expression	[7]
Dedicator of cytokinesis protein 1 (DOCK1)	OTCFV3ON	DOCK1_HUMAN	Decreases Expression	[7]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[7]
Transcription factor Dp-2 (TFDP2)	OTKQFX5H	TFDP2_HUMAN	Decreases Expression	[7]
Fas-activated serine/threonine kinase (FASTK)	OTTHFZMP	FASTK_HUMAN	Decreases Expression	[7]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Increases Expression	[7]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Decreases Expression	[7]
Glutamate receptor ionotropic, NMDA 2C (GRIN2C)	OTV7ZA9O	NMDE3_HUMAN	Decreases Expression	[7]
Nuclear mitotic apparatus protein 1 (NUMA1)	OTTKAVG4	NUMA1_HUMAN	Increases Expression	[7]
Protein disulfide-isomerase A6 (PDIA6)	OT8YBR17	PDIA6_HUMAN	Increases Expression	[7]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Decreases Expression	[7]
Transcription factor E2F5 (E2F5)	OT1XWING	E2F5_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)	OTBOSJHO	TRADD_HUMAN	Increases Expression	[7]
Voltage-dependent R-type calcium channel subunit alpha-1E (CACNA1E)	OTHATMLU	CAC1E_HUMAN	Decreases Expression	[7]
Programmed cell death protein 2 (PDCD2)	OTUOGSDJ	PDCD2_HUMAN	Decreases Expression	[7]
Bcl-2 homologous antagonist/killer (BAK1)	OTDP6ILW	BAK_HUMAN	Increases Expression	[7]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase LMTK1 (AATK)	OTVHAX5N	LMTK1_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase RBBP6 (RBBP6)	OTTVG4HU	RBBP6_HUMAN	Increases Expression	[7]
E3 ubiquitin-protein ligase SIAH1 (SIAH1)	OT29A838	SIAH1_HUMAN	Decreases Expression	[7]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Increases Expression	[7]
TRAF3-interacting protein 1 (TRAF3IP1)	OTLCC64B	MIPT3_HUMAN	Decreases Expression	[7]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Increases Expression	[7]
Unconventional myosin-XVIIIa (MYO18A)	OT2YPT7O	MY18A_HUMAN	Increases Expression	[7]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Increases Expression	[7]
Zinc finger protein ubi-d4 (DPF2)	OTL0JH2C	REQU_HUMAN	Decreases Expression	[7]
Bcl-2-like protein 2 (BCL2L2)	OTMKVO0J	B2CL2_HUMAN	Increases Expression	[7]
TRAF family member-associated NF-kappa-B activator (TANK)	OTZSGFIK	TANK_HUMAN	Decreases Expression	[7]
Caspase-10 (CASP10)	OTE6J88E	CASPA_HUMAN	Increases Expression	[7]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)	OTB82PFO	TNR14_HUMAN	Increases Expression	[7]
Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)	OTVZ7I3A	TNR25_HUMAN	Decreases Expression	[7]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)	OTFYDEES	AT2A3_HUMAN	Increases Expression	[7]
Modulator of apoptosis 1 (MOAP1)	OTVF3LUG	MOAP1_HUMAN	Decreases Expression	[7]
PRKC apoptosis WT1 regulator protein (PAWR)	OTKY7W52	PAWR_HUMAN	Increases Expression	[7]
Bcl-2-modifying factor (BMF)	OT90NSLI	BMF_HUMAN	Decreases Expression	[7]
Parkinson disease protein 7 (PARK7)	OT0SKNTG	PARK7_HUMAN	Decreases Expression	[7]
Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)	OTT3DOOL	M3K14_HUMAN	Increases Expression	[7]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Increases Expression	[7]
Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)	OT53LJGW	M3K3_HUMAN	Decreases Expression	[7]
BAG family molecular chaperone regulator 1 (BAG1)	OTRQNIA4	BAG1_HUMAN	Decreases Expression	[7]
B-cell CLL/lymphoma 7 protein family member B (BCL7B)	OT8DQQRD	BCL7B_HUMAN	Increases Expression	[7]
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1)	OTJP4U7K	HNRL1_HUMAN	Increases Expression	[7]
Oxidoreductase HTATIP2 (HTATIP2)	OT9MZ4QO	HTAI2_HUMAN	Increases Expression	[7]
TNF receptor-associated factor 4 (TRAF4)	OTJLRVMC	TRAF4_HUMAN	Decreases Expression	[7]
E3 ubiquitin-protein ligase TRAIP (TRAIP)	OTMPT9Y2	TRAIP_HUMAN	Decreases Expression	[7]
Caspase recruitment domain-containing protein 10 (CARD10)	OT2RPM4I	CAR10_HUMAN	Decreases Expression	[7]
Caspase recruitment domain-containing protein 6 (CARD6)	OTEI1PJ1	CARD6_HUMAN	Decreases Expression	[7]
Caspase recruitment domain-containing protein 14 (CARD14)	OTADQHOV	CAR14_HUMAN	Decreases Expression	[7]
Caspase recruitment domain-containing protein 11 (CARD11)	OTRCTLYC	CAR11_HUMAN	Decreases Expression	[7]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)	OT87E7HW	B2L14_HUMAN	Increases Expression	[7]
NACHT, LRR and PYD domains-containing protein 1 (NLRP1)	OT4BNNOS	NLRP1_HUMAN	Increases Expression	[7]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Increases Expression	[7]
Caspase recruitment domain-containing protein 9 (CARD9)	OTJ81AWD	CARD9_HUMAN	Increases Expression	[7]
Bcl-2-like protein 12 (BCL2L12)	OTS6IFZY	B2L12_HUMAN	Decreases Expression	[7]
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2)	OTPGYWKC	NOD2_HUMAN	Increases Expression	[7]
p53-regulated apoptosis-inducing protein 1 (TP53AIP1)	OT1XVNDP	TPIP1_HUMAN	Decreases Expression	[7]
Bcl-2-like protein 10 (BCL2L10)	OTYXQJ3I	B2L10_HUMAN	Increases Expression	[7]
NLR family CARD domain-containing protein 4 (NLRC4)	OTAIA3NA	NLRC4_HUMAN	Decreases Expression	[7]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Increases Expression	[7]
Voltage-dependent calcium channel subunit alpha-2/delta-2 (CACNA2D2)	OTFJXVQQ	CA2D2_HUMAN	Decreases Expression	[7]
Bifunctional apoptosis regulator (BFAR)	OTTBG0V7	BFAR_HUMAN	Decreases Expression	[7]
Hematopoietic cell signal transducer (HCST)	OTILCB4K	HCST_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Decreases Expression	[7]
Peflin (PEF1)	OTY24CUW	PEF1_HUMAN	Increases Expression	[7]
Serine/threonine-protein kinase 17A (STK17A)	OTS87MOT	ST17A_HUMAN	Decreases Expression	[7]
Death domain-associated protein 6 (DAXX)	OTX6O7PL	DAXX_HUMAN	Decreases Expression	[7]
Lipid transferase CIDEB (CIDEB)	OT873IYM	CIDEB_HUMAN	Increases Expression	[7]
NADH dehydrogenase 1 alpha subcomplex subunit 12 (NDUFA12)	OTCD6I5M	NDUAC_HUMAN	Increases Expression	[7]
Death-associated protein kinase 2 (DAPK2)	OTWODUQG	DAPK2_HUMAN	Decreases Expression	[7]
Inhibitor of growth protein 1 (ING1)	OTEZBRKW	ING1_HUMAN	Increases Expression	[7]
CASP8-associated protein 2 (CASP8AP2)	OTTWT68S	C8AP2_HUMAN	Decreases Expression	[7]
BAG family molecular chaperone regulator 5 (BAG5)	OT0J97C6	BAG5_HUMAN	Increases Expression	[7]
Apoptosis-associated speck-like protein containing a CARD (PYCARD)	OT67RON3	ASC_HUMAN	Decreases Expression	[7]
Calpain-11 (CAPN11)	OTEHK57V	CAN11_HUMAN	Decreases Expression	[7]
Bcl-2-related ovarian killer protein (BOK)	OTDQPDIX	BOK_HUMAN	Decreases Expression	[7]
Tumor necrosis factor ligand superfamily member 18 (TNFSF18)	OT3ANRX1	TNF18_HUMAN	Increases Expression	[7]
FAS-associated factor 1 (FAF1)	OTGAMLM4	FAF1_HUMAN	Decreases Expression	[7]
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1)	OTUN9GUS	NOD1_HUMAN	Decreases Expression	[7]
RAC-gamma serine/threonine-protein kinase (AKT3)	OT5M2LFI	AKT3_HUMAN	Increases Expression	[7]
Caspase recruitment domain-containing protein 8 (CARD8)	OTXXZYWU	CARD8_HUMAN	Increases Expression	[7]
TNF receptor-associated factor 6 (TRAF6)	OTA5GO5K	TRAF6_HUMAN	Decreases Expression	[7]
Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)	OTL1D484	RIPK3_HUMAN	Increases Expression	[7]
NF-kappa-B essential modulator (IKBKG)	OTNWJWSD	NEMO_HUMAN	Decreases Expression	[7]
Calpain-6 (CAPN6)	OT8K5PR5	CAN6_HUMAN	Decreases Expression	[7]
Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)	OT1FISGN	TNR11_HUMAN	Decreases Expression	[7]
NADH dehydrogenase 1 beta subcomplex subunit 8, mitochondrial (NDUFB8)	OTW4A4Q0	NDUB8_HUMAN	Decreases Expression	[12]
Cytochrome c oxidase subunit 2 (COX2)	OTTMVBJJ	COX2_HUMAN	Decreases Expression	[12]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Secretion	[13]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[14]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Secretion	[13]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Increases Expression	[14]
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)	OTRE1M1T	SDHB_HUMAN	Decreases Expression	[12]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[15]
Transforming protein RhoA (RHOA)	OT6YOJ9N	RHOA_HUMAN	Increases Expression	[16]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[16]
Ras-related protein Rap-1A (RAP1A)	OT5RH6TI	RAP1A_HUMAN	Increases Expression	[16]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Phosphorylation	[13]
Transient receptor potential cation channel subfamily V member 1 (TRPV1)	OTHHDR03	TRPV1_HUMAN	Increases Activity	[11]

Indication(s) of Nicotine

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Approved	[4]
Nicotine dependence	6C4A.2	Approved	[5]
Pellagra	N.A.	Approved	[4]
Tobacco dependence	6C4A.2	Clinical trial	[6]

Nicotine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Nicotinic acetylcholine receptor (nAChR)	TTJSZTB	NOUNIPROTAC	Antagonist	[28]

Nicotine Interacts with 13 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[29]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[29]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Metabolism	[30]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[31]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[29]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[29]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Metabolism	[32]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[29]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[29]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[33]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[29]
Cytochrome P450 2A13 (CYP2A13)	DEXZA9U	CP2AD_HUMAN	Metabolism	[34]
Nicotinate dehydrogenase (nicA)	DE4AMLP	NICA_PSEPK	Metabolism	[35]

Nicotine Interacts with 458 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Decreases Activity	[36]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[37]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Decreases Oxidation	[38]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Expression	[39]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[40]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Increases Phosphorylation	[41]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Decreases Activity	[42]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[17]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Increases Expression	[17]
Angiotensin-converting enzyme (ACE)	OTDF1964	ACE_HUMAN	Increases Expression	[17]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Increases Expression	[17]
Regulatory factor X-associated protein (RFXAP)	OTX46DKQ	RFXAP_HUMAN	Decreases Expression	[18]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Decreases Expression	[18]
Receptor-type tyrosine-protein phosphatase alpha (PTPRA)	OTZA82J1	PTPRA_HUMAN	Decreases Expression	[18]
Ras-related protein Rab-6A (RAB6A)	OTLS86J5	RAB6A_HUMAN	Decreases Expression	[18]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Decreases Expression	[18]
Contactin-1 (CNTN1)	OT7RNPEY	CNTN1_HUMAN	Decreases Expression	[18]
Rho guanine nucleotide exchange factor 7 (ARHGEF7)	OT9BPJCL	ARHG7_HUMAN	Decreases Expression	[18]
E3 ubiquitin-protein ligase RBBP6 (RBBP6)	OTTVG4HU	RBBP6_HUMAN	Decreases Expression	[18]
Histone-lysine N-methyltransferase 2C (KMT2C)	OTC59BCO	KMT2C_HUMAN	Decreases Expression	[18]
Fasciculation and elongation protein zeta-1 (FEZ1)	OTWCXPRE	FEZ1_HUMAN	Decreases Expression	[18]
Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)	OTT5JX1F	LITAF_HUMAN	Decreases Expression	[18]
Echinoderm microtubule-associated protein-like 4 (EML4)	OTJC45TA	EMAL4_HUMAN	Decreases Expression	[18]
Copper chaperone for superoxide dismutase (CCS)	OTXHT3QO	CCS_HUMAN	Increases Expression	[43]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Decreases Expression	[43]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Decreases Expression	[43]
Syntaxin-binding protein 3 (STXBP3)	OTTTYMAQ	STXB3_HUMAN	Increases Expression	[19]
Chloride intracellular channel protein 1 (CLIC1)	OTYLFWNG	CLIC1_HUMAN	Decreases Expression	[19]
Segment polarity protein dishevelled homolog DVL-2 (DVL2)	OTMNYNCM	DVL2_HUMAN	Decreases Expression	[19]
Chromodomain-helicase-DNA-binding protein 2 (CHD2)	OTRKL6YC	CHD2_HUMAN	Increases Expression	[19]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)	OT1Z1ZXE	OGT1_HUMAN	Increases Expression	[19]
Apoptosis regulatory protein Siva (SIVA1)	OTDT0XZK	SIVA_HUMAN	Decreases Expression	[19]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)	OTR7WJES	DC1L2_HUMAN	Increases Expression	[19]
E3 ubiquitin-protein ligase parkin (PRKN)	OTJBN41W	PRKN_HUMAN	Decreases Expression	[19]
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)	OT45AHMB	JIP4_HUMAN	Increases Expression	[19]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Increases Expression	[19]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Increases Expression	[19]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Decreases Expression	[19]
Serine protease 1 (PRSS1)	OTA425AX	TRY1_HUMAN	Decreases Expression	[19]
Laminin subunit beta-1 (LAMB1)	OT6J9LJR	LAMB1_HUMAN	Increases Expression	[19]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Decreases Expression	[19]
Complement component C7 (C7)	OTZ27VJN	CO7_HUMAN	Increases Expression	[19]
Nucleoprotein TPR (TPR)	OTUBBA4W	TPR_HUMAN	Increases Expression	[19]
Acylamino-acid-releasing enzyme (APEH)	OTX258QE	ACPH_HUMAN	Decreases Expression	[19]
Glucosidase 2 subunit beta (PRKCSH)	OTJCQYUU	GLU2B_HUMAN	Decreases Expression	[19]
Membrane cofactor protein (CD46)	OTQ8NWJD	MCP_HUMAN	Increases Expression	[19]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Decreases Expression	[19]
Creatine kinase S-type, mitochondrial (CKMT2)	OT1KNPI1	KCRS_HUMAN	Decreases Expression	[19]
S-adenosylmethionine decarboxylase proenzyme (AMD1)	OTKAGZY3	DCAM_HUMAN	Increases Expression	[19]
Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)	OT8DXMS3	E2AK2_HUMAN	Increases Expression	[19]
Thymidylate kinase (DTYMK)	OTJXYQYK	KTHY_HUMAN	Decreases Expression	[19]
Calreticulin (CALR)	OTYD2TR1	CALR_HUMAN	Increases Expression	[19]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Decreases Expression	[19]
GTP cyclohydrolase 1 (GCH1)	OTOZ6NSL	GCH1_HUMAN	Increases Expression	[19]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Decreases Expression	[19]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Increases Expression	[19]
Transgelin-2 (TAGLN2)	OTUXZGDQ	TAGL2_HUMAN	Decreases Expression	[19]
Patatin-like phospholipase domain-containing protein 4 (PNPLA4)	OT5CVDJM	PLPL4_HUMAN	Decreases Expression	[19]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)	OTTOMI8J	PK3CA_HUMAN	Increases Expression	[19]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[19]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Increases Expression	[19]
Translation initiation factor IF-2, mitochondrial (MTIF2)	OTAIOZ0J	IF2M_HUMAN	Increases Expression	[19]
F-actin-capping protein subunit alpha-2 (CAPZA2)	OTHAO4V2	CAZA2_HUMAN	Increases Expression	[19]
Glioma pathogenesis-related protein 1 (GLIPR1)	OT0FGQK7	GLIP1_HUMAN	Increases Expression	[19]
Deoxyhypusine synthase (DHPS)	OTQIG7BL	DHYS_HUMAN	Decreases Expression	[19]
RNA-binding protein 25 (RBM25)	OTVOUOAG	RBM25_HUMAN	Increases Expression	[19]
DNA ligase 4 (LIG4)	OT40DNXU	DNLI4_HUMAN	Increases Expression	[19]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10)	OTLMZGBE	GBG10_HUMAN	Increases Expression	[19]
Serpin H1 (SERPINH1)	OTKGI7BS	SERPH_HUMAN	Decreases Expression	[19]
H(+)/Cl(-) exchange transporter 3 (CLCN3)	OTEEXNMU	CLCN3_HUMAN	Increases Expression	[19]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[19]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Decreases Expression	[19]
Protein transport protein Sec61 subunit gamma (SEC61G)	OT7MJRXY	SC61G_HUMAN	Increases Expression	[19]
Myosin light polypeptide 6 (MYL6)	OT84YKPM	MYL6_HUMAN	Decreases Expression	[19]
CMP-sialic acid transporter (SLC35A1)	OTPWOOVA	S35A1_HUMAN	Increases Expression	[19]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Increases Expression	[19]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Increases Expression	[19]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)	OTSK5GFC	P2R3A_HUMAN	Increases Expression	[19]
Phosphatidylinositol-glycan biosynthesis class F protein (PIGF)	OTJKE6VW	PIGF_HUMAN	Increases Expression	[19]
Son of sevenless homolog 1 (SOS1)	OTTCWXC3	SOS1_HUMAN	Increases Expression	[19]
Zinc finger protein Rlf (RLF)	OTCSPZVK	RLF_HUMAN	Increases Expression	[19]
Chromobox protein homolog 3 (CBX3)	OTOP9RLD	CBX3_HUMAN	Increases Expression	[19]
Origin recognition complex subunit 2 (ORC2)	OTLIYP8M	ORC2_HUMAN	Increases Expression	[19]
Zinc transporter ZIP6 (SLC39A6)	OTCYF466	S39A6_HUMAN	Increases Expression	[19]
Golgin subfamily A member 4 (GOLGA4)	OTCMEHNJ	GOGA4_HUMAN	Increases Expression	[19]
Serine incorporator 3 (SERINC3)	OTQ1LAJ1	SERC3_HUMAN	Increases Expression	[19]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Increases Expression	[19]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Increases Expression	[19]
Cyclin-dependent kinase 13 (CDK13)	OT3P7JF1	CDK13_HUMAN	Increases Expression	[19]
UDP-glucose 4-epimerase (GALE)	OTVFS16E	GALE_HUMAN	Decreases Expression	[19]
Protocadherin Fat 1 (FAT1)	OTF174DH	FAT1_HUMAN	Increases Expression	[19]
Serum paraoxonase/arylesterase 2 (PON2)	OT55NCTD	PON2_HUMAN	Increases Expression	[19]
Thyroid receptor-interacting protein 11 (TRIP11)	OT4FJEAR	TRIPB_HUMAN	Increases Expression	[19]
Serine/threonine-protein kinase N2 (PKN2)	OTW0SOID	PKN2_HUMAN	Increases Expression	[19]
DNA damage-binding protein 1 (DDB1)	OTTR2L3Z	DDB1_HUMAN	Decreases Expression	[19]
NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)	OTR848KZ	NDUA5_HUMAN	Increases Expression	[19]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)	OTN7XAUD	LRRF1_HUMAN	Increases Expression	[19]
Transmembrane protein 41B (TMEM41B)	OTW0B0KS	TM41B_HUMAN	Increases Expression	[19]
Heterochromatin protein 1-binding protein 3 (HP1BP3)	OTTJ5LX2	HP1B3_HUMAN	Increases Expression	[19]
Pre-mRNA-splicing factor 38B (PRPF38B)	OTQLH551	PR38B_HUMAN	Increases Expression	[19]
Lysine-specific demethylase 7A (KDM7A)	OT1VGYCX	KDM7A_HUMAN	Increases Expression	[19]
Serine/threonine-protein kinase TAO1 (TAOK1)	OTFFLV6Q	TAOK1_HUMAN	Increases Expression	[19]
Ninein (NIN)	OTVH3M4Z	NIN_HUMAN	Increases Expression	[19]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Increases Expression	[19]
DNA topoisomerase 2-binding protein 1 (TOPBP1)	OT6UPZPD	TOPB1_HUMAN	Increases Expression	[19]
PHD finger protein 3 (PHF3)	OTNOYLG9	PHF3_HUMAN	Increases Expression	[19]
Probable ATP-dependent RNA helicase DDX17 (DDX17)	OTXRMMBP	DDX17_HUMAN	Increases Expression	[19]
DNA repair protein RAD50 (RAD50)	OTYMU9G1	RAD50_HUMAN	Increases Expression	[19]
snRNA-activating protein complex subunit 3 (SNAPC3)	OTSGZZCJ	SNPC3_HUMAN	Increases Expression	[19]
PHD finger protein 21A (PHF21A)	OTU3FFG4	PF21A_HUMAN	Increases Expression	[19]
THO complex subunit 1 (THOC1)	OTVABJ4Z	THOC1_HUMAN	Increases Expression	[19]
Chloride channel CLIC-like protein 1 (CLCC1)	OTTXCXVT	CLCC1_HUMAN	Increases Expression	[19]
Protein SCAF11 (SCAF11)	OTX59D0X	SCAFB_HUMAN	Increases Expression	[19]
Mediator of RNA polymerase II transcription subunit 28 (MED28)	OTEDM1L5	MED28_HUMAN	Increases Expression	[19]
Pantothenate kinase 3 (PANK3)	OT77CFJ6	PANK3_HUMAN	Increases Expression	[19]
Arginine and glutamate-rich protein 1 (ARGLU1)	OTRVRZ4Z	ARGL1_HUMAN	Increases Expression	[19]
DDB1- and CUL4-associated factor 16 (DCAF16)	OT60PR7J	DCA16_HUMAN	Increases Expression	[19]
Polypyrimidine tract-binding protein 2 (PTBP2)	OTF4S7NE	PTBP2_HUMAN	Increases Expression	[19]
Splicing factor 3B subunit 6 (SF3B6)	OTPRKS6S	SF3B6_HUMAN	Increases Expression	[19]
Protein PRRC2C (PRRC2C)	OTBX3MXM	PRC2C_HUMAN	Increases Expression	[19]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[44]
Protein kinase C beta type (PRKCB)	OTYQ0656	KPCB_HUMAN	Affects Localization	[44]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Increases Expression	[44]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Increases Expression	[45]
Beta-1 adrenergic receptor (ADRB1)	OTQBWN4U	ADRB1_HUMAN	Increases Expression	[45]
Deoxyribonuclease-2-alpha (DNASE2)	OT6RC1BL	DNS2A_HUMAN	Decreases Expression	[20]
NF-kappa-B inhibitor epsilon (NFKBIE)	OTLAYEL9	IKBE_HUMAN	Decreases Expression	[20]
Serine/threonine-protein kinase 25 (STK25)	OT4YPNTF	STK25_HUMAN	Increases Expression	[20]
Krueppel-like factor 11 (KLF11)	OTKVQDJD	KLF11_HUMAN	Decreases Expression	[20]
Phospholipase D2 (PLD2)	OT86I3WH	PLD2_HUMAN	Increases Expression	[20]
Mothers against decapentaplegic homolog 9 (SMAD9)	OTK4M1H8	SMAD9_HUMAN	Increases Expression	[20]
C-C motif chemokine 16 (CCL16)	OTOOQI1F	CCL16_HUMAN	Decreases Expression	[20]
Death effector domain-containing protein (DEDD)	OTIL349E	DEDD_HUMAN	Decreases Expression	[20]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Decreases Expression	[20]
Erythropoietin (EPO)	OTZ90CN4	EPO_HUMAN	Increases Expression	[20]
T-cell surface glycoprotein CD4 (CD4)	OT7Z5LNF	CD4_HUMAN	Decreases Expression	[20]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Decreases Expression	[20]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[20]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Decreases Expression	[20]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Expression	[20]
Retinoic acid receptor gamma (RARG)	OT8LHMDH	RARG_HUMAN	Decreases Expression	[20]
CD59 glycoprotein (CD59)	OTSUMQDH	CD59_HUMAN	Increases Expression	[20]
POU domain, class 2, transcription factor 1 (POU2F1)	OTK7ELJ0	PO2F1_HUMAN	Increases Expression	[20]
Interleukin-9 (IL9)	OTK4XO6Q	IL9_HUMAN	Decreases Expression	[20]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Increases Expression	[20]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Decreases Expression	[20]
Thyrotropin receptor (TSHR)	OT0BC8LB	TSHR_HUMAN	Increases Expression	[20]
Interferon alpha/beta receptor 1 (IFNAR1)	OTD4OOFK	INAR1_HUMAN	Decreases Expression	[20]
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)	OT2D9DOV	TNR1A_HUMAN	Decreases Expression	[20]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Decreases Expression	[20]
Transcription factor BTF3 (BTF3)	OT5ZZFJL	BTF3_HUMAN	Decreases Expression	[20]
Integrin alpha-L (ITGAL)	OTCUQAIS	ITAL_HUMAN	Decreases Expression	[20]
C5a anaphylatoxin chemotactic receptor 1 (C5AR1)	OT58QDI9	C5AR1_HUMAN	Decreases Expression	[20]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Decreases Expression	[20]
E3 ubiquitin-protein ligase CBL (CBL)	OTTKELCU	CBL_HUMAN	Increases Expression	[20]
C-X-C chemokine receptor type 2 (CXCR2)	OTISGW7L	CXCR2_HUMAN	Decreases Expression	[20]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Decreases Expression	[20]
Platelet-activating factor receptor (PTAFR)	OT2133DF	PTAFR_HUMAN	Decreases Expression	[20]
Nuclear transcription factor Y subunit beta (NFYB)	OTXSE7KW	NFYB_HUMAN	Decreases Expression	[20]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[20]
Hepatocyte growth factor-like protein (MST1)	OTOC4UNG	HGFL_HUMAN	Decreases Expression	[20]
Interleukin-3 receptor subunit alpha (IL3RA)	OTDC3Y8O	IL3RA_HUMAN	Decreases Expression	[20]
Embryonic growth/differentiation factor 1 (GDF1)	OTZ1VRBH	GDF1_HUMAN	Increases Expression	[20]
Proteasome subunit beta type-6 (PSMB6)	OT9VXPNW	PSB6_HUMAN	Decreases Expression	[20]
Ephrin type-A receptor 3 (EPHA3)	OTZJF3ML	EPHA3_HUMAN	Decreases Expression	[20]
cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)	OTZEXEFH	KAP3_HUMAN	Increases Expression	[20]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[20]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Expression	[20]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Decreases Expression	[20]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Increases Expression	[20]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[20]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Decreases Expression	[20]
Tumor necrosis factor ligand superfamily member 6 (FASLG)	OTZARCHH	TNFL6_HUMAN	Increases Expression	[20]
C-C chemokine receptor type 5 (CCR5)	OTP5FMZ4	CCR5_HUMAN	Increases Expression	[20]
C-C chemokine receptor type 6 (CCR6)	OT61JMYX	CCR6_HUMAN	Decreases Expression	[20]
Signal transducer and activator of transcription 2 (STAT2)	OTO9G2RZ	STAT2_HUMAN	Decreases Expression	[20]
Ephrin type-B receptor 3 (EPHB3)	OT4XD8O3	EPHB3_HUMAN	Decreases Expression	[20]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Decreases Expression	[20]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B)	OTNUPLUJ	CKS1_HUMAN	Decreases Expression	[20]
Large ribosomal subunit protein eL8 (RPL7A)	OT6E6UKF	RL7A_HUMAN	Decreases Expression	[20]
Small ribosomal subunit protein eS25 (RPS25)	OTKLWED2	RS25_HUMAN	Increases Expression	[20]
Transcription elongation factor SPT4 (SUPT4H1)	OTB3UCTB	SPT4H_HUMAN	Decreases Expression	[20]
Tyrosine-protein kinase BTK (BTK)	OTG3CDVK	BTK_HUMAN	Decreases Expression	[20]
Protein CBFA2T1 (RUNX1T1)	OT30DED5	MTG8_HUMAN	Decreases Expression	[20]
Lymphotoxin-beta (LTB)	OTUFS8CF	TNFC_HUMAN	Decreases Expression	[20]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Increases Expression	[20]
Nucleoside diphosphate kinase 3 (NME3)	OT0CA0GF	NDK3_HUMAN	Decreases Expression	[20]
Phospholipase D1 (PLD1)	OTMVUKW6	PLD1_HUMAN	Decreases Expression	[20]
Transcription factor Dp-1 (TFDP1)	OT6RZ7VT	TFDP1_HUMAN	Decreases Expression	[20]
Helicase-like transcription factor (HLTF)	OTRX2OSF	HLTF_HUMAN	Decreases Expression	[20]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)	OTRHB9SR	NHRF2_HUMAN	Decreases Expression	[20]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Decreases Expression	[20]
Cocaine- and amphetamine-regulated transcript protein (CARTPT)	OTTE4V9S	CART_HUMAN	Decreases Expression	[20]
POU domain class 2-associating factor 1 (POU2AF1)	OTOO6WHL	OBF1_HUMAN	Decreases Expression	[20]
Anti-Muellerian hormone type-2 receptor (AMHR2)	OT95APPM	AMHR2_HUMAN	Decreases Expression	[20]
Serine/threonine-protein kinase LMTK1 (AATK)	OTVHAX5N	LMTK1_HUMAN	Increases Expression	[20]
MAP kinase-activating death domain protein (MADD)	OTUFYVGG	MADD_HUMAN	Decreases Expression	[20]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Decreases Expression	[20]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Increases Expression	[46]
Transcription factor JunB (JUNB)	OTG2JXV5	JUNB_HUMAN	Increases Expression	[46]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[46]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Increases Expression	[46]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[46]
Signal transducer and activator of transcription 6 (STAT6)	OTCKMP49	STAT6_HUMAN	Increases Expression	[46]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Expression	[46]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Increases Expression	[46]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Affects Expression	[47]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Affects Expression	[47]
Metalloproteinase inhibitor 4 (TIMP4)	OT8A68SW	TIMP4_HUMAN	Affects Expression	[47]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[48]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Increases Expression	[48]
Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)	OT7FOIK2	LOX5_HUMAN	Increases Expression	[48]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Decreases Expression	[48]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[48]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Increases Expression	[48]
Transcription factor E2F1 (E2F1)	OTLKYBBC	E2F1_HUMAN	Increases Expression	[48]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Increases Expression	[48]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Decreases Expression	[48]
Mitogen-activated protein kinase 8 (MAPK8)	OTEREYS5	MK08_HUMAN	Increases Phosphorylation	[39]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[39]
Cytochrome P450 26A1 (CYP26A1)	OTL1DFWV	CP26A_HUMAN	Decreases Expression	[49]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)	OT2NV3AN	CP11A_HUMAN	Decreases Expression	[50]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[50]
Zinc finger protein SNAI2 (SNAI2)	OT7Y8EJ2	SNAI2_HUMAN	Increases Expression	[21]
Zinc finger protein SNAI1 (SNAI1)	OTDPYAMC	SNAI1_HUMAN	Increases Expression	[21]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Increases Activity	[21]
Polycomb complex protein BMI-1 (BMI1)	OTROVLJ0	BMI1_HUMAN	Increases Expression	[21]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Increases Expression	[21]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Increases Expression	[21]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[51]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Increases Expression	[51]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Increases Expression	[51]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Increases Expression	[51]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[51]
Ankyrin repeat and BTB/POZ domain-containing protein 3 (ABTB3)	OT3PLG38	ABTB3_HUMAN	Increases Expression	[22]
Envoplakin-like protein (EVPLL)	OT1BCQEW	EVPLL_HUMAN	Increases Expression	[22]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[22]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)	OTGD8TID	FLRT2_HUMAN	Increases Expression	[22]
D-3-phosphoglycerate dehydrogenase (PHGDH)	OT1LMRTG	SERA_HUMAN	Increases Expression	[22]
Ephrin-A2 (EFNA2)	OTEAUKRX	EFNA2_HUMAN	Increases Expression	[22]
Sushi repeat-containing protein SRPX2 (SRPX2)	OT6A63TX	SRPX2_HUMAN	Increases Expression	[22]
Kinesin-like protein KIF21B (KIF21B)	OTFXFIU3	KI21B_HUMAN	Increases Expression	[22]
Immunoglobulin superfamily member 3 (IGSF3)	OT6GWBAF	IGSF3_HUMAN	Increases Expression	[22]
Gamma-glutamylcyclotransferase (GGCT)	OTKAICP5	GGCT_HUMAN	Increases Splicing	[22]
Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3)	OTDA431Y	ENTP3_HUMAN	Increases Expression	[22]
Mediator of RNA polymerase II transcription subunit 24 (MED24)	OTU4SJQ1	MED24_HUMAN	Increases Expression	[22]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[22]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Increases Expression	[22]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Increases Expression	[22]
Glycoprotein hormones alpha chain (CGA)	OT00U3Y3	GLHA_HUMAN	Increases Expression	[22]
Lactotransferrin (LTF)	OT8JWCZ0	TRFL_HUMAN	Decreases Expression	[22]
Keratin, type II cytoskeletal 6B (KRT6B)	OTBXJYHY	K2C6B_HUMAN	Increases Expression	[22]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[22]
Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)	OTTLGRGH	GNAI2_HUMAN	Increases Splicing	[22]
Neprilysin (MME)	OT5Q39P8	NEP_HUMAN	Increases Expression	[22]
Galectin-1 (LGALS1)	OT8LDFWR	LEG1_HUMAN	Increases Expression	[22]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Increases Expression	[22]
Coiled-coil domain-containing protein 159 (CCDC159)	OTFKSPMZ	CC159_HUMAN	Increases Expression	[22]
Ras-related C3 botulinum toxin substrate 2 (RAC2)	OTAOHFNH	RAC2_HUMAN	Increases Expression	[22]
Fumarylacetoacetase (FAH)	OTGZA1YR	FAAA_HUMAN	Increases Expression	[22]
Homeobox protein Hox-B9 (HOXB9)	OTMVHQOU	HXB9_HUMAN	Increases Expression	[22]
Ganglioside GM2 activator (GM2A)	OTIRWZC0	SAP3_HUMAN	Increases Expression	[22]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Increases Expression	[22]
Keratin, type I cytoskeletal 15 (KRT15)	OTS6WLF7	K1C15_HUMAN	Increases Expression	[22]
Small proline-rich protein 2D (SPRR2D)	OT47THNK	SPR2D_HUMAN	Increases Expression	[22]
Protein S100-A2 (S100A2)	OTTGHJ1H	S10A2_HUMAN	Increases Expression	[22]
Neurotensin receptor type 1 (NTSR1)	OTTJUTE3	NTR1_HUMAN	Increases Expression	[22]
Caspase-14 (CASP14)	OTKY93H9	CASPE_HUMAN	Increases Expression	[22]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Splicing	[22]
Interferon alpha-inducible protein 27, mitochondrial (IFI27)	OTI2XGIT	IFI27_HUMAN	Increases Expression	[22]
Cathelicidin antimicrobial peptide (CAMP)	OT3Y8011	CAMP_HUMAN	Increases Expression	[22]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[22]
ATP synthase subunit epsilon, mitochondrial (ATP5F1E)	OTMPLAIS	ATP5E_HUMAN	Increases Splicing	[22]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Increases Splicing	[22]
Ribose-phosphate pyrophosphokinase 1 (PRPS1)	OTN3A6CN	PRPS1_HUMAN	Increases Splicing	[22]
Rho-related GTP-binding protein RhoE (RND3)	OTXMXPIH	RND3_HUMAN	Increases Splicing	[22]
Small ribosomal subunit protein eS24 (RPS24)	OTSNKIL5	RS24_HUMAN	Increases Splicing	[22]
Keratin, type II cuticular Hb5 (KRT85)	OT67IP7F	KRT85_HUMAN	Increases Expression	[22]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Increases Expression	[22]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Increases Splicing	[22]
Paired box protein Pax-8 (PAX8)	OTRPD9MI	PAX8_HUMAN	Increases Expression	[22]
Cytochrome P450 4F3 (CYP4F3)	OTYNSQAM	CP4F3_HUMAN	Increases Expression	[22]
Transcription intermediary factor 1-beta (TRIM28)	OTE38OBF	TIF1B_HUMAN	Increases Splicing	[22]
Melatonin-related receptor (GPR50)	OT0EJBM4	MTR1L_HUMAN	Increases Expression	[22]
Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)	OT1QHOS2	NF2L1_HUMAN	Increases Splicing	[22]
Transmembrane glycoprotein NMB (GPNMB)	OTB7KQKV	GPNMB_HUMAN	Increases Expression	[22]
C3a anaphylatoxin chemotactic receptor (C3AR1)	OT8J0TF8	C3AR_HUMAN	Increases Expression	[22]
Protein Aster-B (GRAMD1B)	OTCG1GX2	ASTRB_HUMAN	Increases Expression	[22]
Interferon-induced protein 44-like (IFI44L)	OTXKORJP	IF44L_HUMAN	Increases Expression	[22]
SH3 domain-containing protein 19 (SH3D19)	OTVU3VS2	SH319_HUMAN	Increases Splicing	[22]
Late cornified envelope protein 1B (LCE1B)	OT7BLO6L	LCE1B_HUMAN	Increases Expression	[22]
Terminal nucleotidyltransferase 4A (TENT4A)	OT0G3KR0	PAPD7_HUMAN	Increases Splicing	[22]
Keratin, type II cytoskeletal 80 (KRT80)	OTAU54U3	K2C80_HUMAN	Increases Expression	[22]
TMF-regulated nuclear protein 1 (TRNP1)	OTYYV8LN	TRNP1_HUMAN	Increases Expression	[22]
Olfactomedin-4 (OLFM4)	OTELHN9L	OLFM4_HUMAN	Decreases Expression	[22]
Solute carrier family 25 member 48 (SLC25A48)	OTAMLAGE	S2548_HUMAN	Decreases Expression	[22]
Activity-regulated cytoskeleton-associated protein (ARC)	OTN2QQPG	ARC_HUMAN	Increases Expression	[22]
5'-deoxynucleotidase HDDC2 (HDDC2)	OTSO0JP4	HDDC2_HUMAN	Increases Expression	[22]
Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)	OTYAKC55	LRAD3_HUMAN	Increases Splicing	[22]
Neuronal PAS domain-containing protein 3 (NPAS3)	OT8D1ILB	NPAS3_HUMAN	Decreases Expression	[22]
Prominin-2 (PROM2)	OTT8IVS7	PROM2_HUMAN	Increases Expression	[22]
Synaptopodin (SYNPO)	OTICDJAB	SYNPO_HUMAN	Increases Expression	[22]
Cilia- and flagella-associated protein 43 (CFAP43)	OT6R8UGG	CFA43_HUMAN	Decreases Expression	[22]
Protein FAM83F (FAM83F)	OTGGJRO7	FA83F_HUMAN	Increases Expression	[22]
Interferon-induced protein 44 (IFI44)	OTOKSZVA	IFI44_HUMAN	Increases Expression	[22]
Retinoic acid early transcript 1E (RAET1E)	OTLR3CEC	RAE1E_HUMAN	Increases Expression	[22]
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2)	OTH77FBE	G6PT3_HUMAN	Increases Expression	[22]
Prospero homeobox protein 1 (PROX1)	OT68R6IO	PROX1_HUMAN	Increases Expression	[22]
Phosphatidate cytidylyltransferase 1 (CDS1)	OT2F591M	CDS1_HUMAN	Increases Splicing	[22]
Solute carrier organic anion transporter family member 2A1 (SLCO2A1)	OT3062CA	SO2A1_HUMAN	Increases Expression	[22]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1)	OTIUA60B	SH3K1_HUMAN	Increases Expression	[22]
Androgen-dependent TFPI-regulating protein (ADTRP)	OTFI2BQX	ADTRP_HUMAN	Increases Expression	[22]
Gasdermin-A (GSDMA)	OT912R2E	GSDMA_HUMAN	Increases Expression	[22]
SH3 and cysteine-rich domain-containing protein (STAC)	OTRVBSLR	STAC_HUMAN	Increases Expression	[22]
Cell growth regulator with EF hand domain protein 1 (CGREF1)	OTBZQX97	CGRE1_HUMAN	Increases Expression	[22]
Melanophilin (MLPH)	OT7ADCXL	MELPH_HUMAN	Increases Expression	[22]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Increases Expression	[22]
Tubulointerstitial nephritis antigen-like (TINAGL1)	OTZZO56M	TINAL_HUMAN	Increases Expression	[22]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)	OTH88TXU	ADA19_HUMAN	Increases Expression	[22]
Transmembrane protein 222 (TMEM222)	OTWFLPK2	TM222_HUMAN	Increases Splicing	[22]
Beta-defensin 129 (DEFB129)	OT1R2LZM	DB129_HUMAN	Decreases Expression	[22]
CXADR-like membrane protein (CLMP)	OTU7C3GQ	CLMP_HUMAN	Increases Expression	[22]
Protein S100-A14 (S100A14)	OTVFJJ91	S10AE_HUMAN	Increases Expression	[22]
SH2 domain-containing protein 2A (SH2D2A)	OTQSKW7U	SH22A_HUMAN	Increases Expression	[22]
Triggering receptor expressed on myeloid cells 1 (TREM1)	OTCVFEE6	TREM1_HUMAN	Increases Expression	[22]
Serine palmitoyltransferase 3 (SPTLC3)	OTZDX6PT	SPTC3_HUMAN	Increases Expression	[22]
G patch domain-containing protein 2 (GPATCH2)	OT09TY4W	GPTC2_HUMAN	Increases Splicing	[22]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[22]
Protocadherin Fat 2 (FAT2)	OTRGT3E8	FAT2_HUMAN	Increases Expression	[22]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Increases Splicing	[22]
Coiled-coil domain-containing protein 167 (CCDC167)	OTUIAUE7	CC167_HUMAN	Increases Expression	[22]
Cysteine-rich C-terminal protein 1 (CRCT1)	OTPYME8V	CRCT1_HUMAN	Increases Expression	[22]
STEAP1 protein (STEAP1)	OTJMW5R9	STEA1_HUMAN	Increases Expression	[22]
Protein mono-ADP-ribosyltransferase PARP4 (PARP4)	OTXBK59G	PARP4_HUMAN	Increases Splicing	[22]
Hippocalcin-like protein 4 (HPCAL4)	OT793RNP	HPCL4_HUMAN	Increases Expression	[22]
Angiopoietin-4 (ANGPT4)	OT881M3K	ANGP4_HUMAN	Increases Expression	[22]
Kallikrein-5 (KLK5)	OT2TQXS7	KLK5_HUMAN	Increases Expression	[22]
Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)	OTJQL0I3	HEY1_HUMAN	Increases Expression	[22]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Increases Expression	[22]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)	OTZKVLVJ	CP17A_HUMAN	Decreases Expression	[52]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Decreases Expression	[52]
Histone deacetylase 1 (HDAC1)	OTQDNOXZ	HDAC1_HUMAN	Increases Expression	[52]
Histone deacetylase 7 (HDAC7)	OTQ3P0XA	HDAC7_HUMAN	Increases Expression	[52]
Histone deacetylase 2 (HDAC2)	OTUYVFKN	HDAC2_HUMAN	Increases Expression	[52]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[53]
ETS domain-containing protein Elk-1 (ELK1)	OTH9MXD6	ELK1_HUMAN	Increases Phosphorylation	[53]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Increases Expression	[53]
Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9)	OTR94VKQ	ACHA9_HUMAN	Increases Expression	[53]
RNA binding protein fox-1 homolog 3 (RBFOX3)	OTL0F3D6	RFOX3_HUMAN	Increases Expression	[54]
Dynamin-1-like protein (DNM1L)	OTXK1Q1G	DNM1L_HUMAN	Increases Expression	[26]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Increases Expression	[55]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Decreases Expression	[56]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Increases Secretion	[57]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Phosphorylation	[58]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[59]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Activity	[60]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Increases Expression	[61]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Increases Expression	[62]
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Increases Secretion	[63]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Secretion	[63]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Degradation	[24]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Secretion	[64]
Osteocalcin (BGLAP)	OTK1YLWQ	OSTCN_HUMAN	Decreases Expression	[65]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[66]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Increases Expression	[59]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Increases Activity	[60]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Increases Secretion	[67]
High affinity nerve growth factor receptor (NTRK1)	OTJORQAU	NTRK1_HUMAN	Increases Expression	[62]
Integrin beta-3 (ITGB3)	OTWCK1K6	ITB3_HUMAN	Decreases Expression	[68]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Secretion	[57]
Integrin beta-1 (ITGB1)	OT6G1IAR	ITB1_HUMAN	Decreases Expression	[69]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Decreases Expression	[70]
Progesterone receptor (PGR)	OT0FZ3QE	PRGR_HUMAN	Decreases Expression	[66]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[71]
Tyrosine 3-monooxygenase (TH)	OT6ZORKP	TY3H_HUMAN	Increases Expression	[72]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Increases Expression	[54]
Involucrin (IVL)	OT4VPNGY	INVO_HUMAN	Decreases Expression	[70]
Heat shock protein HSP 90-alpha (HSP90AA1)	OTLG1WPK	HS90A_HUMAN	Increases Expression	[73]
Tumor necrosis factor receptor superfamily member 16 (NGFR)	OTPKSM49	TNR16_HUMAN	Increases Expression	[62]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Increases Expression	[59]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Increases Expression	[59]
Integrin alpha-IIb (ITGA2B)	OT4Y17PY	ITA2B_HUMAN	Decreases Expression	[68]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Increases Secretion	[74]
Dopamine beta-hydroxylase (DBH)	OTC6I2SP	DOPO_HUMAN	Increases Expression	[72]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Increases Expression	[61]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Increases Expression	[62]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[75]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[76]
Phenylethanolamine N-methyltransferase (PNMT)	OTGLCPE8	PNMT_HUMAN	Increases Expression	[72]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Expression	[77]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Decreases Expression	[78]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Increases Expression	[79]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Increases Phosphorylation	[58]
Lysosome-associated membrane glycoprotein 2 (LAMP2)	OTLUGEJC	LAMP2_HUMAN	Decreases Expression	[80]
Elongation factor 2 (EEF2)	OTZ7SZ39	EF2_HUMAN	Increases Expression	[26]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Decreases Expression	[77]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Decreases Expression	[77]
Neutrophil cytosol factor 1 (NCF1)	OTMHT3G6	NCF1_HUMAN	Increases Expression	[81]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Increases Expression	[82]
Folate receptor alpha (FOLR1)	OT0QZ0H6	FOLR1_HUMAN	Increases Expression	[83]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Increases Activity	[84]
Neuronal acetylcholine receptor subunit beta-2 (CHRNB2)	OTNAT2M5	ACHB2_HUMAN	Increases Expression	[54]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[85]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[86]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Increases Expression	[79]
Ribosomal protein S6 kinase beta-1 (RPS6KB1)	OTAELNGX	KS6B1_HUMAN	Increases Phosphorylation	[87]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Increases Secretion	[88]
Endothelial transcription factor GATA-2 (GATA2)	OTBP2QQ2	GATA2_HUMAN	Increases Expression	[89]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[90]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Phosphorylation	[81]
Serum paraoxonase/arylesterase 1 (PON1)	OTD0Z2XO	PON1_HUMAN	Decreases Activity	[91]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Activity	[82]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Activity	[84]
G1/S-specific cyclin-D2 (CCND2)	OTDULQF9	CCND2_HUMAN	Decreases Expression	[78]
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)	OTCZQY1U	ACHA3_HUMAN	Decreases Expression	[92]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Increases Expression	[81]
Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)	OTBUSUTE	ACHA7_HUMAN	Decreases Expression	[92]
Pigment epithelium-derived factor (SERPINF1)	OTWZH98J	PEDF_HUMAN	Decreases Expression	[23]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Increases Activity	[79]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Decreases Expression	[83]
Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)	OT1H0ZXC	ACHA4_HUMAN	Increases Expression	[93]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Increases Expression	[59]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Decreases Expression	[56]
C-X-C chemokine receptor type 3 (CXCR3)	OTIGS220	CXCR3_HUMAN	Increases Expression	[54]
Adenosine 5'-monophosphoramidase HINT1 (HINT1)	OTQIR8LF	HINT1_HUMAN	Increases Expression	[94]
Oxysterols receptor LXR-beta (NR1H2)	OT4APA60	NR1H2_HUMAN	Decreases Expression	[56]
Histone H2B type 1-D (H2BC5)	OTXDTDHN	H2B1D_HUMAN	Increases Expression	[71]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Response To Substance	[78]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Increases Expression	[54]
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)	OTIIGGZ2	RS27A_HUMAN	Decreases Expression	[95]
Casein kinase II subunit alpha (CSNK2A1)	OT9T8WQM	CSK21_HUMAN	Increases Expression	[71]
Histone H3.1 (H3C1)	OTGBGOZW	H31_HUMAN	Increases Expression	[71]
Cytochrome c (CYCS)	OTBFALJD	CYC_HUMAN	Decreases Secretion	[96]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Expression	[81]
Protein kinase C zeta type (PRKCZ)	OTN2FE42	KPCZ_HUMAN	Increases Activity	[97]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Decreases Expression	[98]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Increases Phosphorylation	[99]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Decreases Expression	[56]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Increases Expression	[80]
Interleukin-18 (IL18)	OTBB2A8O	IL18_HUMAN	Increases Secretion	[64]
Histone RNA hairpin-binding protein (SLBP)	OTVYYQRT	SLBP_HUMAN	Decreases Expression	[71]
Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6)	OTT6W86V	ACHA6_HUMAN	Decreases Expression	[92]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Increases Expression	[88]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Increases Expression	[100]
Scavenger receptor class B member 1 (SCARB1)	OTAE1UA1	SCRB1_HUMAN	Decreases Expression	[56]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)	OTZM6MHU	NLRP3_HUMAN	Increases Expression	[64]
Flavin-containing monooxygenase 3 (FMO3)	OT1G2EV3	FMO3_HUMAN	Increases Metabolism	[101]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Affects Response To Substance	[102]
LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3)	OTA7IBLE	LYSM3_HUMAN	Affects Response To Substance	[102]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Increases Response To Substance	[103]
Pleckstrin homology domain-containing family G member 1 (PLEKHG1)	OTDVYW2F	PKHG1_HUMAN	Affects Response To Substance	[102]
Choline O-acetyltransferase (CHAT)	OTEJWQ45	CLAT_HUMAN	Increases ADR	[104]
Solute carrier family 22 member 2 (SLC22A2)	OTGFK1AL	S22A2_HUMAN	Affects Response To Substance	[105]
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)	OTGIL2YD	ACHA5_HUMAN	Increases Response To Substance	[106]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Increases ADR	[104]
Plastin-2 (LCP1)	OTK61F2A	PLSL_HUMAN	Affects Response To Substance	[102]
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)	OTO8JQJA	PK3CB_HUMAN	Increases ADR	[104]
Neuronal acetylcholine receptor subunit alpha-2 (CHRNA2)	OTVQQSMK	ACHA2_HUMAN	Affects Response To Substance	[107]

References

• [1] ClinicalTrials.gov (NCT02102100) The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
• [2] methyl salicylate FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2471).
• [4] Nicotine FDA Label
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2585).
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• [18] Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
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