Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2Y3P4)

• Drug Name: Chlorogenic acid Drug Info
• Synonyms: CHLOROGENIC ACID; 327-97-9; 3-Caffeoylquinic acid; 3-O-Caffeoylquinic acid; 3-(3,4-Dihydroxycinnamoyl)quinic acid; Chlorogenate; Heriguard; Hlorogenic acid; Caffeoyl quinic acid; NSC-407296; 3-Caffeoylquinate; UNII-318ADP12RI; 5-O-(3,4-Dihydroxycinnamoyl)-L-quinic acid; CCRIS 1400; Chlorogenic acid (8CI); EINECS 206-325-6; NSC 70861; NSC 407296; 3-trans-Caffeoylquinic acid; CHEMBL284616; 318ADP12RI; CHEBI:16112; 1,3,4,5-tetrahydroxycyclohexanecarboxylic acid 3-(3,4-dihydroxycinnamate); 3-(3,4-Dihydroxycinnamoyl)quinate

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 1794427
  ChEBI ID: CHEBI:16112
  CAS Number: CAS 202650-88-2
  TTD Drug ID: DM2Y3P4
  VARIDT Drug ID: DR00938

Molecule-Related Drug Atlas

Drug(s) Targeting Glucose-6-phosphate translocase (SLC37A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
S 0957	DM9HA8G	Discovery agent	N.A.	Investigative	[6]
S 1743	DMA5GOX	Discovery agent	N.A.	Investigative	[6]
S-4048	DME5HIR	Discovery agent	N.A.	Investigative	[7]
Kodaistatin A	DMAJKRX	Discovery agent	N.A.	Investigative	[8]
Kodaistatin C	DM72WQ3	Discovery agent	N.A.	Investigative	[8]
S 3025	DMZN0RW	Discovery agent	N.A.	Investigative	[9]
Mumbaistatin	DM6SYMH	Discovery agent	N.A.	Investigative	[10]

Drug(s) Affected By Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[2]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[2]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[2]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[17]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[18]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[24]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[19]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[35]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[38]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[41]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[43]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[47]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[50]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[64]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[69]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[71]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[72]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[73]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[84]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[84]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[84]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[85]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[86]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[66]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[87]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[89]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[90]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[95]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[44]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[97]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[98]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[29]

Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[61]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[107]

Drug(s) Affected By Translationally-controlled tumor protein (TPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[111]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[113]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[119]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[29]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[123]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[130]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[118]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[41]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Fructose	DM43AN2	Vomiting	MD90	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[151]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[154]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[11]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Methyltestosterone	DMWLFGO	Advanced cancer	2A00-2F9Z	Approved	[154]
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[154]

Drug(s) Affected By Desmoglein-3 (DSG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[158]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[159]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[2]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[161]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[162]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[166]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[167]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]

Drug(s) Affected By Fibrillin-2 (FBN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[169]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[158]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[175]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[178]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[179]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[185]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[186]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[187]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[189]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[190]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[191]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[59]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[19]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[118]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[195]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[2]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[2]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[2]

Drug(s) Affected By Cytoglobin (CYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[196]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[198]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[158]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[100]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[158]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[2]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[2]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[2]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[2]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[203]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[2]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[204]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[205]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]

Drug(s) Affected By Amine oxidase B (MAOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[210]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[3]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[212]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[213]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[215]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[216]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Selenium	DM25CGV	N. A.	N. A.	Approved	[219]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[222]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[225]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[230]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[231]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[232]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[56]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[239]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[240]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[241]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[245]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[246]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[248]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[249]

Drug(s) Affected By Coagulation factor X (F10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[182]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[250]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[251]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[198]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[252]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[253]

Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[5]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[13]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[190]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[255]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[118]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[88]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[259]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[88]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[257]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[11]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[51]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[216]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Selenium	DM25CGV	N. A.	N. A.	Approved	[53]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[262]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[263]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucose-6-phosphate translocase (SLC37A4)	TT1KPBZ	G6PT1_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Gene/Protein Processing	[2]
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[2]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Gene/Protein Processing	[3]
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Gene/Protein Processing	[3]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[2]
Aquaporin-1 (AQP1)	OTX5MYX9	AQP1_HUMAN	Gene/Protein Processing	[2]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Gene/Protein Processing	[2]
ATP-citrate synthase (ACLY)	OTRL9ZRP	ACLY_HUMAN	Gene/Protein Processing	[2]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Gene/Protein Processing	[4]
Biotin--protein ligase (HLCS)	OTPDUX30	BPL1_HUMAN	Gene/Protein Processing	[5]

References

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