Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWYE7A)

• Drug Name: Protoporphyrin IX Drug Info
• Synonyms: protoporphyrin IX; protoporphyrin; 553-12-8; Ooporphyrin; Protoporpyrin IX; Porphyrinogen IX; Protoporphyrin IX disodium; Kammerer's prophyrin; ppIX; Protoporphyrin IX (VAN); H2ppIX; Kammerer's porphyrin; MLS001074731; UNII-C2K325S808; NSC2632; NSC 2632; EINECS 209-033-7; 3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic acid; SMR000127405; 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-diethenyl-3,8,13,17-tetramethyl-; CHEMBL267548; CHEBI:15430; C34H34N4O4

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4971
  ChEBI ID: CHEBI:15430
  CAS Number: CAS 553-12-8
  TTD Drug ID: DMWYE7A
  VARIDT Drug ID: DR01454

Molecule-Related Drug Atlas

Drug(s) Targeting Glutathione-dependent PGD synthase (HPGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Praziquantel	DMOU1PK	Flatworm infection	1F70-1F86	Approved	[11]
HF-0220	DMI4C90	Alzheimer disease	8A20	Phase 2	[12]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[13]
Cibacron blue	DMWE1N8	Discovery agent	N.A.	Investigative	[14]
S-hexylglutathione	DMNWP02	Discovery agent	N.A.	Investigative	[15]
HQL-79	DMSHYQ3	Discovery agent	N.A.	Investigative	[16]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[19]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[22]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[38]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[47]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[54]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[46]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[63]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[60]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[66]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[67]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[69]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[70]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[82]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[86]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[88]
Ketoprofen	DMRKXPT	Bursitis		Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[96]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[97]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[98]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[99]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[101]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[104]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[106]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[107]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Fructose	DM43AN2	Vomiting	MD90	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[116]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[68]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[122]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[89]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[123]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[5]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[125]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[126]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[136]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[139]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[142]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[149]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[150]

Drug(s) Affected By Corticoliberin (CRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[152]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[152]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Haloperidol	DM96SE0	Delirium		Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Terbutaline	DMD4381	Asthma	CA23	Approved	[153]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[152]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[154]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[155]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[161]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[74]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[138]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[168]

Drug(s) Affected By Porphobilinogen deaminase (HMBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[170]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[172]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[173]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[60]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[175]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[67]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[180]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[183]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[185]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[187]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[188]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[196]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[199]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]

Drug(s) Affected By Erythroid transcription factor (GATA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[170]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[204]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[205]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[206]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[207]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[208]

Drug(s) Affected By 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[209]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[210]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[211]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[212]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[213]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[214]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[211]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[218]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[187]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[220]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[221]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[222]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[218]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[227]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[228]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[229]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[217]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[89]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[187]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[220]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[232]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[56]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[236]
Fructose	DM43AN2	Vomiting	MD90	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[243]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[244]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[245]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[246]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[249]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[250]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[251]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[252]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[253]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[255]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[256]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[97]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[261]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[64]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[268]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[3]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[270]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[271]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[272]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[273]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[274]

Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[276]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[278]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[280]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[282]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[280]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[180]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[256]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[184]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[185]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[74]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[283]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[284]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[245]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[285]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[288]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[291]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[292]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[295]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[297]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[298]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[299]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[298]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[300]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[301]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[302]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[305]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]

Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[202]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[170]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[307]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[204]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[308]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[311]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[311]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[312]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[313]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[315]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[316]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[317]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[215]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[319]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[80]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[319]

Drug(s) Affected By Heme oxygenase 2 (HMOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[81]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[322]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[323]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[211]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[230]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[326]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]

Drug(s) Affected By Copper-transporting ATPase 2 (ATP7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[330]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[87]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glutathione-dependent PGD synthase (HPGDS)	TTCYE56	HPGDS_HUMAN	Inhibitor	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)	OTJXOUCL	HEM0_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[6]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[8]
Copper-transporting ATPase 2 (ATP7B)	OTPWLNCO	ATP7B_HUMAN	Biotransformations	[9]
Corticoliberin (CRH)	OT2MOC4T	CRF_HUMAN	Protein Interaction/Cellular Processes	[10]

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