Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDZ6Q3)

• Drug Name: Napabucasin Drug Info
• Synonyms: 83280-65-3; UNII-Z1HHM49K7O; 2-acetylnaphtho[2,3-b]furan-4,9-dione; Z1HHM49K7O; 2-Acetylnaphtho(2,3-b)furan-4,9-dione; 2-Acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione; Napabucasin [USAN:INN]; Napabucasin (BBI608); 2-Acetylfuranonaphthoquinone; CHEMBL64130; Napabucasin (JAN/USAN/INN); SCHEMBL1883845; Napabucasin - BBI 608/ FNQ; 2-Acetylfuro-1,4-naphthoquinone; DPHUWDIXHNQOSY-UHFFFAOYSA-N; MolPort-039-101-321; EX-A1314; ZINC13306865; s7977; AKOS027470201; DB12155; CS-1747; ACN-053294; HY-13919

Indication

Disease Entry	ICD 11	Status	REF
Colorectal cancer	2B91.Z	Phase 3	[1]
Pancreatic cancer	2C10	Phase 3	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[2]
Advanced malignancy	2A00-2F9Z	Phase 1/2	[1]
Gastrointestinal cancer	2C11	Phase 1/2	[1]
Hepatocellular carcinoma	2C12.02	Phase 1/2	[1]
Recurrent glioblastoma	2A00.00	Phase 1/2	[3]
Recurring respiratory infection	CA07-CA45	Phase 1/2	[1]
Haematological malignancy	2B33.Y	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 10331844
  CAS Number: CAS 83280-65-3
  TTD Drug ID: DMDZ6Q3

Molecule-Related Drug Atlas

Drug(s) Targeting Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[6]
Golotimod	DMKZN3A	Immune System disease	4A01-4B41	Phase 2	[7]
NT219	DMOYS1N	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[8]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[1]
Atiprimod	DM84YEC	Multiple myeloma	2A83	Phase 1/2	[9]
OPB-31121	DM6VGO3	Hepatocellular carcinoma	2C12.02	Phase 1/2	[10]
IMX-110	DMNHZS4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
GLG-801	DMY1CP9	Chronic lymphocytic leukaemia	2A82.0	Phase 1/2	[1]
OPB-51602	DM760FA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
TAK-114	DMTXE19	Ulcerative colitis	DD71	Phase 1	[12]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[17]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[21]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[22]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[23]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[24]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[30]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[31]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[35]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[39]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[51]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[55]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[57]

Drug(s) Affected By Serine/threonine-protein kinase LATS1 (LATS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[70]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[73]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[76]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[78]
Fructose	DM43AN2	Vomiting	MD90	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[87]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[88]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[97]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[98]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[99]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]

Drug(s) Affected By Large ribosomal subunit protein uL10 (RPLP0)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[109]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[111]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[112]
9-hydroxyoctadecadienoic acid	DM0FWNJ	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Fructose	DM43AN2	Vomiting	MD90	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[121]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[122]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[124]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[129]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[127]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[132]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[133]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[130]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[135]

Drug(s) Affected By Electron transfer flavoprotein subunit alpha, mitochondrial (ETFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[140]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Mucin-1 (MUC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[144]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[132]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[147]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[45]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[153]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[156]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[157]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[159]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[160]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[161]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[152]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[166]

Drug(s) Affected By Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[169]

Drug(s) Affected By Endoglin (ENG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[173]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[175]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[13]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[185]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[190]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[18]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[199]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[202]

Drug(s) Affected By Hematopoietic progenitor cell antigen CD34 (CD34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[203]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[205]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[206]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[204]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[209]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[210]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[210]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[212]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[212]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[220]

Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[221]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[222]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[229]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[230]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[231]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[238]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[239]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[240]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[124]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[243]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[244]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[250]

Drug(s) Affected By Ataxin-1 (ATXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[253]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[212]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[212]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[212]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[257]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[156]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[260]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[262]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[238]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[264]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[269]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[270]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[274]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[276]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[238]
Bortezomib	DMNO38U	Leukemia		Approved	[277]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[278]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[280]

Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[206]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[171]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[281]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[282]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[283]

Drug(s) Affected By Tyrosine-protein kinase Mer (MERTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[182]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[137]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[284]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[285]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[286]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[288]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[289]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[294]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[295]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]

Drug(s) Affected By Flotillin-2 (FLOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[108]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[298]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[299]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[299]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]

Drug(s) Affected By Tafazzin (TAFAZZIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[300]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]

Drug(s) Affected By Krueppel-like factor 17 (KLF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[303]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[251]

Drug(s) Affected By Mastermind-like protein 1 (MAML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[238]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[305]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[306]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[307]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[311]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[28]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[313]

Drug(s) Affected By Protein smoothened (SMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[316]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]

Drug(s) Affected By Forkhead box protein P1 (FOXP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[290]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[172]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[318]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[95]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[243]

Drug(s) Affected By Protein lin-28 homolog A (LIN28A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[19]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[319]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[269]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[251]

Drug(s) Affected By Dachshund homolog 1 (DACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[322]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[323]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[66]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[324]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Signal transducer and activator of transcription 3 (STAT3)	TTH8FZW	STAT3_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Gene/Protein Processing	[4]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Gene/Protein Processing	[4]
Ataxin-1 (ATXN1)	OTQF0HNR	ATX1_HUMAN	Gene/Protein Processing	[4]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[5]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Gene/Protein Processing	[4]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Gene/Protein Processing	[4]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Gene/Protein Processing	[4]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Gene/Protein Processing	[4]
Dachshund homolog 1 (DACH1)	OTMKNAGG	DACH1_HUMAN	Gene/Protein Processing	[4]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Gene/Protein Processing	[4]

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