Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN3E57)

Drug Name

Levodopa Drug Info

Synonyms

Levodopa (optimized formulation, Parkinson's disease); More effective levodopa (Parkinson's disease), Orion; Levodopa (optimized formulation, Parkinson's disease), Orion

Indication

Disease Entry	ICD 11	Status	REF
Parkinson disease	8A00.0	Approved	[1]

Cross-matching ID

PubChem CID: 6047
ChEBI ID: CHEBI:15765
CAS Number: CAS 59-92-7
TTD Drug ID: DMN3E57
VARIDT Drug ID: DR00125
INTEDE Drug ID: DR0939

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Investigative Drug(s)

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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[9]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[11]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[12]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[13]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[14]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[15]
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[16]
Nicotine	DMWX5CO	Nicotine dependence	6C4A.2	Approved	[17]
Propranolol	DM79NTF	Migraine	8A80	Approved	[18]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[20]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[21]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[22]
Ergotidine	DM78IME	Respiratory allergy	4A80	Approved	[23]
Vitamin C	DMXJ7O8	Vitamin C deficiency	5B56	Approved	[24]
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[25]
Epinephrine	DM3KJBC	Allergy	4A80-4A85	Approved	[26]
Thioguanine	DM7NKEV	Acute myeloid leukaemia	2A60	Approved	[27]
Azathioprine	DMMZSXQ	Organ transplant rejection	NE84	Approved	[28]
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Drug(s) Metabolized By DOPA decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[29]
Droxidopa	DM5YF4M	Neurogenic orthostatic hypotension	8D87.0Y	Approved	[30]
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Drug(s) Metabolized By Tyrosine decarboxylase (tdc)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-tyrosine	DM9O8DT	Malnutrition	5B50-5B71	Approved	[31]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[3]
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[32]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[33]
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[34]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[33]
Progesterone	DMUY35B	Premature labour	JB00	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Breast cancer	2C60-2C65	Approved	[36]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[37]
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Drug(s) Transported By L-type amino acid transporter 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[38]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[39]
Pregabalin	DMDVP3B	Chronic obstructive pulmonary disease	CA22	Approved	[40]
L-leucine	DMQHN7I	Discovery agent	N.A.	Investigative	[38]
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Drug(s) Targeting Dopamine D2 receptor (D2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Parkinson disease	8A00.0	Approved	[41]
Haloperidol	DM96SE0	Schizophrenia	6A20	Approved	[42]
Perphenazine	DMA4MRX	Schizophrenia	6A20	Approved	[43]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[44]
Domperidone	DMBDPY0	Gastrointestinal disease	DE2Z	Approved	[45]
Quetiapine	DM1N62C	Schizophrenia	6A20	Approved	[46]
Pimozide	DMW83TP	Schizophrenia	6A20	Approved	[47]
Chlorpromazine	DMBGZI3	Schizophrenia	6A20	Approved	[48]
Iloperidone	DM6AUFY	Schizophrenia	6A20	Approved	[49]
Risperidone	DMN6DXL	Schizophrenia	6A20	Approved	[50]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D2 receptor (D2R)	TTEX248	DRD2_HUMAN	Modulator	[1]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
L-type amino acid transporter 1 (SLC7A5)	DT48T0N	LAT1_HUMAN	Substrate	[2]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[4]
DOPA decarboxylase (DDC)	DETK9CN	DDC_HUMAN	Substrate	[5]
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Substrate	[6]
Tyrosine decarboxylase (tdc)	DE3HL9N	TYRDC_ENTFA	Substrate	[7] , [8]
Tyrosine decarboxylase (tdc)	DEX2ZLF	TYRDC_LACBR	Substrate	[8]

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References

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