DDI Drug Name |
DDI Drug ID |
Severity |
Mechanism |
Comorbidity |
REF |
Methylergonovine |
DMBEX4O
|
Moderate |
Increased metabolism of Butabarbital caused by Methylergonovine mediated induction of CYP450 enzyme. |
Abortion [JA00]
|
[12] |
Repaglinide |
DM5SXUV
|
Moderate |
Increased metabolism of Butabarbital caused by Repaglinide mediated induction of CYP450 enzyme. |
Acute diabete complication [5A2Y]
|
[13] |
Midostaurin |
DMI6E0R
|
Moderate |
Increased metabolism of Butabarbital caused by Midostaurin mediated induction of CYP450 enzyme. |
Acute myeloid leukaemia [2A60]
|
[14] |
Gilteritinib |
DMTI0ZO
|
Moderate |
Increased metabolism of Butabarbital caused by Gilteritinib mediated induction of CYP450 enzyme. |
Acute myeloid leukaemia [2A60]
|
[15] |
Oliceridine |
DM6MDCF
|
Major |
Increased metabolism of Butabarbital caused by Oliceridine mediated induction of CYP450 enzyme. |
Acute pain [MG31]
|
[16] |
Mitotane |
DMU1GX0
|
Minor |
Increased metabolism of Butabarbital caused by Mitotane mediated induction of CYP450 enzyme. |
Adrenal cancer [2D11]
|
[17] |
Donepezil |
DMIYG7Z
|
Moderate |
Increased metabolism of Butabarbital caused by Donepezil mediated induction of CYP450 enzyme. |
Alzheimer disease [8A20]
|
[18] |
Metronidazole |
DMTIVEN
|
Moderate |
Increased metabolism of Butabarbital caused by Metronidazole mediated induction of CYP450 enzyme. |
Amoebiasis [1A36]
|
[19] |
Ranolazine |
DM0C9IL
|
Major |
Increased metabolism of Butabarbital caused by Ranolazine mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[20] |
Ivabradine |
DM0L594
|
Moderate |
Increased metabolism of Butabarbital caused by Ivabradine mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[21] |
Dronedarone |
DMA8FS5
|
Moderate |
Increased metabolism of Butabarbital caused by Dronedarone mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[22] |
Nifedipine |
DMSVOZT
|
Moderate |
Increased metabolism of Butabarbital caused by Nifedipine mediated induction of CYP450 enzyme. |
Angina pectoris [BA40]
|
[23] |
Bedaquiline |
DM3906J
|
Moderate |
Increased metabolism of Butabarbital caused by Bedaquiline mediated induction of CYP450 enzyme. |
Antimicrobial drug resistance [MG50-MG52]
|
[24] |
Buspirone |
DMBS632
|
Moderate |
Increased metabolism of Butabarbital caused by Buspirone mediated induction of CYP450 enzyme. |
Anxiety disorder [6B00-6B0Z]
|
[25] |
Voriconazole |
DMAOL2S
|
Moderate |
Increased metabolism of Butabarbital caused by Voriconazole mediated induction of CYP450 enzyme. |
Aspergillosis [1F20]
|
[26] |
Montelukast |
DMD157S
|
Moderate |
Increased metabolism of Butabarbital caused by Montelukast mediated induction of CYP450 enzyme. |
Asthma [CA23]
|
[27] |
Aminophylline |
DML2NIB
|
Moderate |
Increased metabolism of Butabarbital caused by Aminophylline mediated induction of CYP450 enzyme. |
Asthma [CA23]
|
[28] |
Tindamax |
DM3OWT4
|
Moderate |
Increased metabolism of Butabarbital caused by Tindamax mediated induction of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[19] |
Chloramphenicol |
DMFXEWT
|
Moderate |
Decreased metabolism of Butabarbital caused by Chloramphenicol mediated inhibition of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[29] |
Telithromycin |
DMZ4P3A
|
Moderate |
Increased metabolism of Butabarbital caused by Telithromycin mediated induction of CYP450 enzyme. |
Bacterial infection [1A00-1C4Z]
|
[30] |
Cariprazine |
DMJYDVK
|
Moderate |
Increased metabolism of Butabarbital caused by Cariprazine mediated induction of CYP450 enzyme. |
Bipolar disorder [6A60]
|
[21] |
Ixabepilone |
DM2OZ3G
|
Moderate |
Increased metabolism of Butabarbital caused by Ixabepilone mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[31] |
Lapatinib |
DM3BH1Y
|
Moderate |
Increased metabolism of Butabarbital caused by Lapatinib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[12] |
LY2835219 |
DM93VBZ
|
Moderate |
Increased metabolism of Butabarbital caused by LY2835219 mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[32] |
Exemestane |
DM9HPW3
|
Moderate |
Increased metabolism of Butabarbital caused by Exemestane mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[33] |
Esterified estrogens |
DM9KZDO
|
Moderate |
Increased metabolism of Butabarbital caused by Esterified estrogens mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[34] |
Tucatinib |
DMBESUA
|
Moderate |
Increased metabolism of Butabarbital caused by Tucatinib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[35] |
Palbociclib |
DMD7L94
|
Moderate |
Increased metabolism of Butabarbital caused by Palbociclib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[12] |
Alpelisib |
DMEXMYK
|
Moderate |
Increased metabolism of Butabarbital caused by Alpelisib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[36] |
Quinestrol |
DMJ6H1Z
|
Moderate |
Increased metabolism of Butabarbital caused by Quinestrol mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[34] |
Tamoxifen |
DMLB0EZ
|
Moderate |
Increased metabolism of Butabarbital caused by Tamoxifen mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[37] |
Cabazitaxel |
DMPAZHC
|
Moderate |
Increased metabolism of Butabarbital caused by Cabazitaxel mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[38] |
Toremifene |
DMQYUWG
|
Moderate |
Increased metabolism of Butabarbital caused by Toremifene mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[39] |
Bosutinib |
DMTI8YE
|
Moderate |
Increased metabolism of Butabarbital caused by Bosutinib mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[40] |
Estradiol |
DMUNTE3
|
Moderate |
Increased metabolism of Butabarbital caused by Estradiol mediated induction of CYP450 enzyme. |
Breast cancer [2C60-2C6Y]
|
[34] |
Atorvastatin |
DMF28YC
|
Moderate |
Increased metabolism of Butabarbital caused by Atorvastatin mediated induction of CYP450 enzyme. |
Cardiovascular disease [BA00-BE2Z]
|
[41] |
Macitentan |
DMP79A1
|
Moderate |
Increased metabolism of Butabarbital caused by Macitentan mediated induction of CYP450 enzyme. |
Cardiovascular disease [BA00-BE2Z]
|
[42] |
Doxercalciferol |
DM6FG1P
|
Moderate |
Increased metabolism of Butabarbital caused by Doxercalciferol mediated induction of CYP450 enzyme. |
Chronic kidney disease [GB61]
|
[43] |
Corticotropin |
DMP9TWZ
|
Moderate |
Increased metabolism of Butabarbital caused by Corticotropin mediated induction of CYP450 enzyme. |
Chronic kidney disease [GB61]
|
[44] |
PF-04449913 |
DMSB068
|
Moderate |
Increased metabolism of Butabarbital caused by PF-04449913 mediated induction of CYP450 enzyme. |
Chronic myelomonocytic leukaemia [2A40]
|
[45] |
Dihydrocodeine |
DMB0FWL
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Dihydrocodeine. |
Chronic pain [MG30]
|
[46] |
Morphine |
DMRMS0L
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Morphine. |
Chronic pain [MG30]
|
[47] |
Anisindione |
DM2C48U
|
Major |
Increased metabolism of Butabarbital caused by Anisindione mediated induction of CYP450 enzyme. |
Coagulation defect [3B10]
|
[48] |
Irinotecan |
DMP6SC2
|
Moderate |
Increased metabolism of Butabarbital caused by Irinotecan mediated induction of CYP450 enzyme. |
Colorectal cancer [2B91]
|
[49] |
Olopatadine |
DMKMWQG
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Olopatadine. |
Conjunctiva disorder [9A60]
|
[50] |
Drospirenone |
DM1A9W3
|
Moderate |
Increased metabolism of Butabarbital caused by Drospirenone mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[34] |
Levonorgestrel |
DM1DP7T
|
Moderate |
Increased metabolism of Butabarbital caused by Levonorgestrel mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[34] |
Ulipristal |
DMBNI20
|
Moderate |
Increased metabolism of Butabarbital caused by Ulipristal mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[21] |
Etonogestrel |
DMKA8J4
|
Moderate |
Increased metabolism of Butabarbital caused by Etonogestrel mediated induction of CYP450 enzyme. |
Contraceptive management [QA21]
|
[34] |
Levobupivacaine |
DM783CH
|
Minor |
Increased metabolism of Butabarbital caused by Levobupivacaine mediated induction of CYP450 enzyme. |
Corneal disease [9A76-9A78]
|
[51] |
Propofol |
DMB4OLE
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Propofol. |
Corneal disease [9A76-9A78]
|
[52] |
Methoxyflurane |
DML0RAE
|
Moderate |
Increased metabolism of Butabarbital caused by Methoxyflurane mediated induction of CYP450 enzyme. |
Corneal disease [9A76-9A78]
|
[53] |
Lidocaine |
DML4ZOT
|
Minor |
Increased metabolism of Butabarbital caused by Lidocaine mediated induction of CYP450 enzyme. |
Corneal disease [9A76-9A78]
|
[54] |
Alfentanil |
DMVO0UB
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Alfentanil. |
Corneal disease [9A76-9A78]
|
[47] |
Remifentanil |
DMZTXCH
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Remifentanil. |
Corneal disease [9A76-9A78]
|
[47] |
Nimodipine |
DMQ0RKZ
|
Moderate |
Increased metabolism of Butabarbital caused by Nimodipine mediated induction of CYP450 enzyme. |
Coronary vasospastic disease [BA85]
|
[23] |
Oxtriphylline |
DMLHSE3
|
Moderate |
Increased metabolism of Butabarbital caused by Oxtriphylline mediated induction of CYP450 enzyme. |
Cough [MD12]
|
[28] |
Methadone |
DMTW6IU
|
Major |
Increased metabolism of Butabarbital caused by Methadone mediated induction of CYP450 enzyme. |
Cough [MD12]
|
[16] |
Mifepristone |
DMGZQEF
|
Moderate |
Increased metabolism of Butabarbital caused by Mifepristone mediated induction of CYP450 enzyme. |
Cushing syndrome [5A70]
|
[55] |
Osilodrostat |
DMIJC9X
|
Moderate |
Increased metabolism of Butabarbital caused by Osilodrostat mediated induction of CYP450 enzyme. |
Cushing syndrome [5A70]
|
[56] |
Ivacaftor |
DMZC1HS
|
Moderate |
Increased metabolism of Butabarbital caused by Ivacaftor mediated induction of CYP450 enzyme. |
Cystic fibrosis [CA25]
|
[57] |
Ethanol |
DMDRQZU
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Ethanol. |
Cystitis [GC00]
|
[58] |
Rivaroxaban |
DMQMBZ1
|
Moderate |
Increased metabolism of Butabarbital caused by Rivaroxaban mediated induction of CYP450 enzyme. |
Deep vein thrombosis [BD71]
|
[59] |
Aprepitant |
DM053KT
|
Moderate |
Increased metabolism of Butabarbital caused by Aprepitant mediated induction of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[60] |
Fluoxetine |
DM3PD2C
|
Minor |
Decreased metabolism of Butabarbital caused by Fluoxetine mediated inhibition of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[61] |
Vilazodone |
DM4LECQ
|
Moderate |
Increased metabolism of Butabarbital caused by Vilazodone mediated induction of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[62] |
Paroxetine |
DM5PVQE
|
Minor |
Increased metabolism of Butabarbital caused by Paroxetine mediated induction of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[63] |
Vortioxetine |
DM6F1PU
|
Moderate |
Increased metabolism of Butabarbital caused by Vortioxetine mediated induction of CYP450 enzyme. |
Depression [6A70-6A7Z]
|
[64] |
Esketamine |
DMVU687
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Esketamine. |
Depression [6A70-6A7Z]
|
[12] |
Griseofulvin |
DMK54YG
|
Moderate |
Altered absorption of Butabarbital caused by Griseofulvin. |
Dermatophytosis [1F28]
|
[65] |
[3H]estrone-3-sulphate |
DMGPF0N
|
Moderate |
Increased metabolism of Butabarbital caused by [3H]estrone-3-sulphate mediated induction of CYP450 enzyme. |
Discovery agent [N.A.]
|
[66] |
PMID28870136-Compound-48 |
DMPIM9L
|
Moderate |
Increased metabolism of Butabarbital caused by PMID28870136-Compound-48 mediated induction of CYP450 enzyme. |
Discovery agent [N.A.]
|
[28] |
Trihexyphenidyl |
DMB19L8
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Trihexyphenidyl. |
Dystonic disorder [8A02]
|
[67] |
Zonisamide |
DM0DTF7
|
Moderate |
Increased metabolism of Butabarbital caused by Zonisamide mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[68] |
Stiripentol |
DMMSDOY
|
Moderate |
Increased metabolism of Butabarbital caused by Stiripentol mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[21] |
Phenytoin |
DMNOKBV
|
Moderate |
Increased metabolism of Butabarbital caused by Phenytoin mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[69] |
Fosphenytoin |
DMOX3LB
|
Moderate |
Increased metabolism of Butabarbital caused by Fosphenytoin mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[69] |
Carbamazepine |
DMZOLBI
|
Minor |
Increased metabolism of Butabarbital caused by Carbamazepine mediated induction of CYP450 enzyme. |
Epilepsy/seizure [8A61-8A6Z]
|
[70] |
Timolol |
DM3NXRU
|
Moderate |
Increased metabolism of Butabarbital caused by Timolol mediated induction of CYP450 enzyme. |
Essential hypertension [BA00]
|
[71] |
Nicardipine |
DMCDYW7
|
Moderate |
Increased metabolism of Butabarbital caused by Nicardipine mediated induction of CYP450 enzyme. |
Essential hypertension [BA00]
|
[23] |
Praziquantel |
DMOU1PK
|
Moderate |
Increased metabolism of Butabarbital caused by Praziquantel mediated induction of CYP450 enzyme. |
Flatworm infection [1F70-1F86]
|
[72] |
Bay 80-6946 |
DMLOS5R
|
Moderate |
Increased metabolism of Butabarbital caused by Bay 80-6946 mediated induction of CYP450 enzyme. |
Follicular lymphoma [2A80]
|
[73] |
Tazemetostat |
DMWP1BH
|
Moderate |
Increased metabolism of Butabarbital caused by Tazemetostat mediated induction of CYP450 enzyme. |
Follicular lymphoma [2A80]
|
[74] |
Solifenacin |
DMG592Q
|
Moderate |
Increased metabolism of Butabarbital caused by Solifenacin mediated induction of CYP450 enzyme. |
Functional bladder disorder [GC50]
|
[75] |
Mirabegron |
DMS1GYT
|
Minor |
Increased metabolism of Butabarbital caused by Mirabegron mediated induction of CYP450 enzyme. |
Functional bladder disorder [GC50]
|
[76] |
Darifenacin |
DMWXLYZ
|
Moderate |
Increased metabolism of Butabarbital caused by Darifenacin mediated induction of CYP450 enzyme. |
Functional bladder disorder [GC50]
|
[77] |
Caspofungin |
DMGQIPT
|
Moderate |
Increased metabolism of Butabarbital caused by Caspofungin mediated induction of CYP450 enzyme. |
Fungal infection [1F29-1F2F]
|
[78] |
Cimetidine |
DMH61ZB
|
Minor |
Altered absorption of Butabarbital caused by Cimetidine. |
Gastro-oesophageal reflux disease [DA22]
|
[79] |
Ripretinib |
DM958QB
|
Moderate |
Increased metabolism of Butabarbital caused by Ripretinib mediated induction of CYP450 enzyme. |
Gastrointestinal stromal tumour [2B5B]
|
[12] |
Sunitinib |
DMCBJSR
|
Moderate |
Increased metabolism of Butabarbital caused by Sunitinib mediated induction of CYP450 enzyme. |
Gastrointestinal stromal tumour [2B5B]
|
[12] |
Avapritinib |
DMK2GZX
|
Moderate |
Increased metabolism of Butabarbital caused by Avapritinib mediated induction of CYP450 enzyme. |
Gastrointestinal stromal tumour [2B5B]
|
[21] |
Brimonidine |
DMQLT4N
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Brimonidine. |
Glaucoma [9C61]
|
[80] |
Ergotamine |
DMKR3C5
|
Moderate |
Increased metabolism of Butabarbital caused by Ergotamine mediated induction of CYP450 enzyme. |
Headache [8A80-8A84]
|
[12] |
Carvedilol |
DMHTEAO
|
Moderate |
Increased metabolism of Butabarbital caused by Carvedilol mediated induction of CYP450 enzyme. |
Heart failure [BD10-BD1Z]
|
[71] |
Digitoxin |
DMWVIGP
|
Moderate |
Increased metabolism of Butabarbital caused by Digitoxin mediated induction of CYP450 enzyme. |
Heart failure [BD10-BD1Z]
|
[81] |
Boceprevir |
DMBSHMF
|
Moderate |
Increased metabolism of Butabarbital caused by Boceprevir mediated induction of CYP450 enzyme. |
Hepatitis virus infection [1E50-1E51]
|
[82] |
Telaprevir |
DMMRV29
|
Moderate |
Increased metabolism of Butabarbital caused by Telaprevir mediated induction of CYP450 enzyme. |
Hepatitis virus infection [1E50-1E51]
|
[82] |
MK-1439 |
DM215WE
|
Moderate |
Increased metabolism of Butabarbital caused by MK-1439 mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[83] |
Fosamprenavir |
DM4W9B3
|
Moderate |
Increased metabolism of Butabarbital caused by Fosamprenavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Fostemsavir |
DM50ILT
|
Minor |
Increased metabolism of Butabarbital caused by Fostemsavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[85] |
Tipranavir |
DM8HJX6
|
Moderate |
Increased metabolism of Butabarbital caused by Tipranavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Efavirenz |
DMC0GSJ
|
Moderate |
Increased metabolism of Butabarbital caused by Efavirenz mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[86] |
Dolutegravir |
DMCZGRE
|
Minor |
Increased metabolism of Butabarbital caused by Dolutegravir mediated induction of UGT. |
Human immunodeficiency virus disease [1C60-1C62]
|
[87] |
Saquinavir |
DMG814N
|
Moderate |
Increased metabolism of Butabarbital caused by Saquinavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Rilpivirine |
DMJ0QOW
|
Moderate |
Increased metabolism of Butabarbital caused by Rilpivirine mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[12] |
Amprenavir |
DMLMXE0
|
Moderate |
Increased metabolism of Butabarbital caused by Amprenavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Darunavir |
DMN3GCH
|
Moderate |
Increased metabolism of Butabarbital caused by Darunavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Atazanavir |
DMSYRBX
|
Moderate |
Increased metabolism of Butabarbital caused by Atazanavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Maraviroc |
DMTL94F
|
Moderate |
Increased metabolism of Butabarbital caused by Maraviroc mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[12] |
Ritonavir |
DMU764S
|
Moderate |
Increased metabolism of Butabarbital caused by Ritonavir mediated induction of CYP450 enzyme. |
Human immunodeficiency virus disease [1C60-1C62]
|
[84] |
Paricalcitol |
DMYBV3G
|
Moderate |
Increased metabolism of Butabarbital caused by Paricalcitol mediated induction of CYP450 enzyme. |
Hyper-parathyroidism [5A51]
|
[43] |
Acebutolol |
DM0TI4U
|
Moderate |
Increased metabolism of Butabarbital caused by Acebutolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[71] |
Penbutolol |
DM4ES8F
|
Moderate |
Increased metabolism of Butabarbital caused by Penbutolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[71] |
Losartan |
DM72JXH
|
Minor |
Increased metabolism of Butabarbital caused by Losartan mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[88] |
Nebivolol |
DM7F1PA
|
Moderate |
Increased metabolism of Butabarbital caused by Nebivolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[71] |
Nisoldipine |
DM7ISKJ
|
Moderate |
Increased metabolism of Butabarbital caused by Nisoldipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[23] |
Levamlodipine |
DM92S6N
|
Moderate |
Increased metabolism of Butabarbital caused by Levamlodipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[23] |
Isradipine |
DMA5XGH
|
Moderate |
Increased metabolism of Butabarbital caused by Isradipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[23] |
Verapamil |
DMA7PEW
|
Moderate |
Increased metabolism of Butabarbital caused by Verapamil mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[89] |
Diltiazem |
DMAI7ZV
|
Moderate |
Increased metabolism of Butabarbital caused by Diltiazem mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[90] |
Labetalol |
DMK8U72
|
Moderate |
Increased metabolism of Butabarbital caused by Labetalol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[71] |
Metoprolol |
DMOJ0V6
|
Moderate |
Increased metabolism of Butabarbital caused by Metoprolol mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[71] |
Felodipine |
DMOSW35
|
Moderate |
Increased metabolism of Butabarbital caused by Felodipine mediated induction of CYP450 enzyme. |
Hypertension [BA00-BA04]
|
[91] |
Tolvaptan |
DMIWFRL
|
Moderate |
Increased metabolism of Butabarbital caused by Tolvaptan mediated induction of CYP450 enzyme. |
Hypo-osmolality/hyponatraemia [5C72]
|
[21] |
Fludrocortisone |
DMUDIR8
|
Moderate |
Increased metabolism of Butabarbital caused by Fludrocortisone mediated induction of CYP450 enzyme. |
Hypo-osmolality/hyponatraemia [5C72]
|
[44] |
Liothyronine |
DM6IR3P
|
Moderate |
Increased metabolism of Butabarbital caused by Liothyronine mediated induction of CYP450 enzyme. |
Hypo-thyroidism [5A00]
|
[21] |
Levothyroxine |
DMHN027
|
Moderate |
Increased metabolism of Butabarbital caused by Levothyroxine mediated induction of CYP450 enzyme. |
Hypo-thyroidism [5A00]
|
[21] |
Lesinurad |
DMUR64T
|
Moderate |
Increased metabolism of Butabarbital caused by Lesinurad mediated induction of CYP450 enzyme. |
Inborn purine/pyrimidine/nucleotide metabolism error [5C55]
|
[92] |
Naloxegol |
DML0B41
|
Moderate |
Increased metabolism of Butabarbital caused by Naloxegol mediated induction of CYP450 enzyme. |
Large intestine motility disorder [DB32]
|
[93] |
Pemigatinib |
DM819JF
|
Moderate |
Increased metabolism of Butabarbital caused by Pemigatinib mediated induction of CYP450 enzyme. |
Liver cancer [2C12]
|
[21] |
Crizotinib |
DM4F29C
|
Moderate |
Increased metabolism of Butabarbital caused by Crizotinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[94] |
Brigatinib |
DM7W94S
|
Moderate |
Increased metabolism of Butabarbital caused by Brigatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[12] |
Ceritinib |
DMB920Z
|
Moderate |
Increased metabolism of Butabarbital caused by Ceritinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[95] |
Erlotinib |
DMCMBHA
|
Moderate |
Increased metabolism of Butabarbital caused by Erlotinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[96] |
Lurbinectedin |
DMEFRTZ
|
Moderate |
Increased metabolism of Butabarbital caused by Lurbinectedin mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[97] |
Osimertinib |
DMRJLAT
|
Moderate |
Increased metabolism of Butabarbital caused by Osimertinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[98] |
Capmatinib |
DMYCXKL
|
Moderate |
Increased metabolism of Butabarbital caused by Capmatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[99] |
Selpercatinib |
DMZR15V
|
Moderate |
Increased metabolism of Butabarbital caused by Selpercatinib mediated induction of CYP450 enzyme. |
Lung cancer [2C25]
|
[21] |
Artemether |
DM48QOT
|
Moderate |
Increased metabolism of Butabarbital caused by Artemether mediated induction of CYP450 enzyme. |
Malaria [1F40-1F45]
|
[12] |
Quinine |
DMSWYF5
|
Moderate |
Increased metabolism of Butabarbital caused by Quinine mediated induction of CYP450 enzyme. |
Malaria [1F40-1F45]
|
[100] |
Mefloquine |
DMWT905
|
Moderate |
Increased metabolism of Butabarbital caused by Mefloquine mediated induction of CYP450 enzyme. |
Malaria [1F40-1F45]
|
[101] |
Idelalisib |
DM602WT
|
Moderate |
Increased metabolism of Butabarbital caused by Idelalisib mediated induction of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[102] |
GDC-0199 |
DMH0QKA
|
Moderate |
Increased metabolism of Butabarbital caused by GDC-0199 mediated induction of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[103] |
IPI-145 |
DMWA24P
|
Moderate |
Increased metabolism of Butabarbital caused by IPI-145 mediated induction of CYP450 enzyme. |
Mature B-cell leukaemia [2A82]
|
[104] |
Acalabrutinib |
DM7GCVW
|
Moderate |
Increased metabolism of Butabarbital caused by Acalabrutinib mediated induction of CYP450 enzyme. |
Mature B-cell lymphoma [2A85]
|
[105] |
Ibrutinib |
DMHZCPO
|
Moderate |
Increased metabolism of Butabarbital caused by Ibrutinib mediated induction of CYP450 enzyme. |
Mature B-cell lymphoma [2A85]
|
[106] |
Ponatinib |
DMYGJQO
|
Moderate |
Increased metabolism of Butabarbital caused by Ponatinib mediated induction of CYP450 enzyme. |
Mature B-cell lymphoma [2A85]
|
[12] |
Vemurafenib |
DM62UG5
|
Moderate |
Increased metabolism of Butabarbital caused by Vemurafenib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[107] |
Selumetinib |
DMC7W6R
|
Moderate |
Increased metabolism of Butabarbital caused by Selumetinib mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[108] |
LGX818 |
DMNQXV8
|
Moderate |
Increased metabolism of Butabarbital caused by LGX818 mediated induction of CYP450 enzyme. |
Melanoma [2C30]
|
[109] |
Estrone |
DM5T6US
|
Moderate |
Increased metabolism of Butabarbital caused by Estrone mediated induction of CYP450 enzyme. |
Menopausal disorder [GA30]
|
[34] |
Ethinyl estradiol |
DMODJ40
|
Moderate |
Increased metabolism of Butabarbital caused by Ethinyl estradiol mediated induction of CYP450 enzyme. |
Menopausal disorder [GA30]
|
[66] |
Allopregnanolone |
DMNLHAC
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Allopregnanolone. |
Mental/behavioural/neurodevelopmental disorder [6E20-6E8Z]
|
[110] |
Nitisinone |
DMVS9WQ
|
Moderate |
Increased metabolism of Butabarbital caused by Nitisinone mediated induction of CYP450 enzyme. |
Metabolism inborn error [5C50]
|
[111] |
Methysergide |
DM1EF73
|
Moderate |
Increased metabolism of Butabarbital caused by Methysergide mediated induction of CYP450 enzyme. |
Migraine [8A80]
|
[12] |
Dihydroergotamine |
DM5IKUF
|
Moderate |
Increased metabolism of Butabarbital caused by Dihydroergotamine mediated induction of CYP450 enzyme. |
Migraine [8A80]
|
[12] |
Ubrogepant |
DM749I3
|
Moderate |
Increased metabolism of Butabarbital caused by Ubrogepant mediated induction of CYP450 enzyme. |
Migraine [8A80]
|
[112] |
Propranolol |
DM79NTF
|
Moderate |
Increased metabolism of Butabarbital caused by Propranolol mediated induction of CYP450 enzyme. |
Migraine [8A80]
|
[71] |
Lasmiditan |
DMXLVDT
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Lasmiditan. |
Migraine [8A80]
|
[113] |
Dihydrotachysterol |
DMFB97P
|
Moderate |
Increased metabolism of Butabarbital caused by Dihydrotachysterol mediated induction of CYP450 enzyme. |
Mineral deficiency [5B5K]
|
[43] |
Flibanserin |
DM70DTN
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Flibanserin. |
Mood disorder [6A60-6E23]
|
[114] |
Panobinostat |
DM58WKG
|
Moderate |
Increased metabolism of Butabarbital caused by Panobinostat mediated induction of CYP450 enzyme. |
Multiple myeloma [2A83]
|
[115] |
Thalidomide |
DM70BU5
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Thalidomide. |
Multiple myeloma [2A83]
|
[116] |
Bexarotene |
DMOBIKY
|
Minor |
Increased metabolism of Butabarbital caused by Bexarotene mediated induction of CYP450 enzyme. |
Mycosis fungoides [2B01]
|
[117] |
Nilotinib |
DM7HXWT
|
Moderate |
Increased metabolism of Butabarbital caused by Nilotinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[118] |
Ruxolitinib |
DM7Q98D
|
Moderate |
Increased metabolism of Butabarbital caused by Ruxolitinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[119] |
Imatinib |
DM7RJXL
|
Moderate |
Increased metabolism of Butabarbital caused by Imatinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[120] |
Dasatinib |
DMJV2EK
|
Moderate |
Increased metabolism of Butabarbital caused by Dasatinib mediated induction of CYP450 enzyme. |
Myeloproliferative neoplasm [2A20]
|
[12] |
Modafinil |
DMYILBE
|
Moderate |
Increased metabolism of Butabarbital caused by Modafinil mediated induction of CYP450 enzyme. |
Narcolepsy [7A20]
|
[121] |
Rolapitant |
DM8XP26
|
Moderate |
Increased metabolism of Butabarbital caused by Rolapitant mediated induction of CYP450 enzyme. |
Nausea/vomiting [MD90]
|
[122] |
Bupropion |
DM5PCS7
|
Moderate |
Antagonize the effect of Butabarbital when combined with Bupropion. |
Nicotine use disorder [6C4A]
|
[123] |
Entrectinib |
DMMPTLH
|
Moderate |
Increased metabolism of Butabarbital caused by Entrectinib mediated induction of CYP450 enzyme. |
Non-small cell lung cancer [2C25]
|
[124] |
Levomethadyl Acetate |
DM06HG5
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Levomethadyl Acetate. |
Opioid use disorder [6C43]
|
[46] |
Apraclonidine |
DMO4PVE
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Apraclonidine. |
Optic nerve disorder [9C40]
|
[80] |
Olaparib |
DM8QB1D
|
Moderate |
Increased metabolism of Butabarbital caused by Olaparib mediated induction of CYP450 enzyme. |
Ovarian cancer [2C73]
|
[12] |
Altretamine |
DMKLAYG
|
Moderate |
Increased metabolism of Butabarbital caused by Altretamine mediated induction of CYP450 enzyme. |
Ovarian cancer [2C73]
|
[125] |
Pentazocine |
DM1XBHS
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Pentazocine. |
Pain [MG30-MG3Z]
|
[47] |
Dextropropoxyphene |
DM23HCX
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Dextropropoxyphene. |
Pain [MG30-MG3Z]
|
[126] |
Butorphanol |
DM5KYPJ
|
Major |
Antagonize the effect of Butabarbital when combined with Butorphanol. |
Pain [MG30-MG3Z]
|
[16] |
Oxymorphone |
DM65AGJ
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Oxymorphone. |
Pain [MG30-MG3Z]
|
[47] |
Levorphanol |
DMGS80V
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Levorphanol. |
Pain [MG30-MG3Z]
|
[47] |
Hydromorphone |
DMHP21E
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Hydromorphone. |
Pain [MG30-MG3Z]
|
[47] |
Dezocine |
DMJDB0Y
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Dezocine. |
Pain [MG30-MG3Z]
|
[47] |
Codeine |
DMJX6ZG
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Codeine. |
Pain [MG30-MG3Z]
|
[47] |
Nalbuphine |
DMOSQGU
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Nalbuphine. |
Pain [MG30-MG3Z]
|
[47] |
Buprenorphine |
DMPRI8G
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Buprenorphine. |
Pain [MG30-MG3Z]
|
[127] |
Hydrocodone |
DMQ2JO5
|
Major |
Increased metabolism of Butabarbital caused by Hydrocodone mediated induction of CYP450 enzyme. |
Pain [MG30-MG3Z]
|
[16] |
Acetaminophen |
DMUIE76
|
Moderate |
Increased metabolism of Butabarbital caused by Acetaminophen mediated induction of CYP450 enzyme. |
Pain [MG30-MG3Z]
|
[128] |
Meperidine |
DMX4GND
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Meperidine. |
Pain [MG30-MG3Z]
|
[21] |
Oxycodone |
DMXLKHV
|
Major |
Increased metabolism of Butabarbital caused by Oxycodone mediated induction of CYP450 enzyme. |
Pain [MG30-MG3Z]
|
[16] |
Biperiden |
DME78OA
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Biperiden. |
Parkinsonism [8A00]
|
[67] |
Benztropine |
DMGZOVN
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Benztropine. |
Parkinsonism [8A00]
|
[67] |
Procyclidine |
DMHFJDT
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Procyclidine. |
Parkinsonism [8A00]
|
[67] |
Pimavanserin |
DMR7IVC
|
Moderate |
Increased metabolism of Butabarbital caused by Pimavanserin mediated induction of CYP450 enzyme. |
Parkinsonism [8A00]
|
[129] |
Doxycycline |
DM7ICNU
|
Moderate |
Increased metabolism of Butabarbital caused by Doxycycline mediated induction of CYP450 enzyme. |
Periodontal disease [DA0C]
|
[130] |
Macimorelin |
DMQYJIR
|
Moderate |
Increased metabolism of Butabarbital caused by Macimorelin mediated induction of CYP450 enzyme. |
Pituitary gland disorder [5A60-5A61]
|
[131] |
Dapsone |
DM4LT8A
|
Minor |
Increased metabolism of Butabarbital caused by Dapsone mediated induction of CYP450 enzyme. |
Pneumonia [CA40]
|
[132] |
Lefamulin |
DME6G97
|
Moderate |
Increased metabolism of Butabarbital caused by Lefamulin mediated induction of CYP450 enzyme. |
Pneumonia [CA40]
|
[133] |
Prednisone |
DM2HG4X
|
Moderate |
Increased metabolism of Butabarbital caused by Prednisone mediated induction of CYP450 enzyme. |
Postoperative inflammation [1A00-CA43]
|
[44] |
Betamethasone |
DMAHJEF
|
Moderate |
Increased metabolism of Butabarbital caused by Betamethasone mediated induction of CYP450 enzyme. |
Postoperative inflammation [1A00-CA43]
|
[44] |
Hydrocortisone |
DMGEMB7
|
Moderate |
Increased metabolism of Butabarbital caused by Hydrocortisone mediated induction of CYP450 enzyme. |
Postoperative inflammation [1A00-CA43]
|
[44] |
Ergonovine |
DM0VEC1
|
Moderate |
Increased metabolism of Butabarbital caused by Ergonovine mediated induction of CYP450 enzyme. |
Postpartum haemorrhage [JA43]
|
[12] |
Lonafarnib |
DMGM2Z6
|
Moderate |
Increased metabolism of Butabarbital caused by Lonafarnib mediated induction of CYP450 enzyme. |
Premature ageing appearance [LD2B]
|
[134] |
Progesterone |
DMUY35B
|
Moderate |
Increased metabolism of Butabarbital caused by Progesterone mediated induction of CYP450 enzyme. |
Preterm labour/delivery [JB00]
|
[34] |
Enzalutamide |
DMGL19D
|
Moderate |
Increased metabolism of Butabarbital caused by Enzalutamide mediated induction of CYP450 enzyme. |
Prostate cancer [2C82]
|
[135] |
Darolutamide |
DMV7YFT
|
Moderate |
Increased metabolism of Butabarbital caused by Darolutamide mediated induction of CYP450 enzyme. |
Prostate cancer [2C82]
|
[136] |
Apremilast |
DMTWS9E
|
Moderate |
Increased metabolism of Butabarbital caused by Apremilast mediated induction of CYP450 enzyme. |
Psoriasis [EA90]
|
[137] |
Riociguat |
DMXBLMP
|
Moderate |
Increased metabolism of Butabarbital caused by Riociguat mediated induction of CYP450 enzyme. |
Pulmonary hypertension [BB01]
|
[138] |
Everolimus |
DM8X2EH
|
Moderate |
Increased metabolism of Butabarbital caused by Everolimus mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[12] |
Axitinib |
DMGVH6N
|
Moderate |
Increased metabolism of Butabarbital caused by Axitinib mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[139] |
Temsirolimus |
DMS104F
|
Moderate |
Increased metabolism of Butabarbital caused by Temsirolimus mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[12] |
Sorafenib |
DMS8IFC
|
Moderate |
Increased metabolism of Butabarbital caused by Sorafenib mediated induction of CYP450 enzyme. |
Renal cell carcinoma [2C90]
|
[140] |
Tofacitinib |
DMBS370
|
Moderate |
Increased metabolism of Butabarbital caused by Tofacitinib mediated induction of CYP450 enzyme. |
Rheumatoid arthritis [FA20]
|
[12] |
Fenoprofen |
DML5VQ0
|
Minor |
Increased metabolism of Butabarbital caused by Fenoprofen mediated induction of CYP450 enzyme. |
Rheumatoid arthritis [FA20]
|
[141] |
Dexamethasone |
DMMWZET
|
Moderate |
Increased metabolism of Butabarbital caused by Dexamethasone mediated induction of CYP450 enzyme. |
Rheumatoid arthritis [FA20]
|
[44] |
Quetiapine |
DM1N62C
|
Moderate |
Increased metabolism of Butabarbital caused by Quetiapine mediated induction of CYP450 enzyme. |
Schizophrenia [6A20]
|
[12] |
Aripiprazole |
DM3NUMH
|
Moderate |
Increased metabolism of Butabarbital caused by Aripiprazole mediated induction of CYP450 enzyme. |
Schizophrenia [6A20]
|
[142] |
Fentanyl |
DM8WAHT
|
Major |
Increased metabolism of Butabarbital caused by Fentanyl mediated induction of CYP450 enzyme. |
Sensation disturbance [MB40]
|
[16] |
Sufentanil |
DMU7YEL
|
Major |
Additive CNS depression effects by the combination of Butabarbital and Sufentanil. |
Sensation disturbance [MB40]
|
[47] |
Avanafil |
DM75CXN
|
Moderate |
Increased metabolism of Butabarbital caused by Avanafil mediated induction of CYP450 enzyme. |
Sexual dysfunction [HA00-HA01]
|
[143] |
Tadalafil |
DMJZHT1
|
Moderate |
Increased metabolism of Butabarbital caused by Tadalafil mediated induction of CYP450 enzyme. |
Sexual dysfunction [HA00-HA01]
|
[21] |
LDE225 |
DMM9F25
|
Moderate |
Increased metabolism of Butabarbital caused by LDE225 mediated induction of CYP450 enzyme. |
Skin cancer [2C30-2C37]
|
[144] |
Gefitinib |
DM15F0X
|
Moderate |
Increased metabolism of Butabarbital caused by Gefitinib mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[96] |
Larotrectinib |
DM26CQR
|
Moderate |
Increased metabolism of Butabarbital caused by Larotrectinib mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[12] |
Methylprednisolone |
DM4BDON
|
Moderate |
Increased metabolism of Butabarbital caused by Methylprednisolone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[44] |
Docetaxel |
DMDI269
|
Moderate |
Increased metabolism of Butabarbital caused by Docetaxel mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[145] |
Trabectedin |
DMG3Y89
|
Moderate |
Increased metabolism of Butabarbital caused by Trabectedin mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[21] |
Armodafinil |
DMGB035
|
Moderate |
Increased metabolism of Butabarbital caused by Armodafinil mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[121] |
LEE011 |
DMMX75K
|
Moderate |
Increased metabolism of Butabarbital caused by LEE011 mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[12] |
Prednisolone |
DMQ8FR2
|
Moderate |
Increased metabolism of Butabarbital caused by Prednisolone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[44] |
Norethindrone |
DMTY169
|
Moderate |
Increased metabolism of Butabarbital caused by Norethindrone mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[66] |
Taxol |
DMUOT9V
|
Moderate |
Increased metabolism of Butabarbital caused by Taxol mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[146] |
Doxorubicin |
DMVP5YE
|
Moderate |
Increased metabolism of Butabarbital caused by Doxorubicin mediated induction of CYP450 enzyme. |
Solid tumour/cancer [2A00-2F9Z]
|
[21] |
Warfarin |
DMJYCVW
|
Major |
Increased metabolism of Butabarbital caused by Warfarin mediated induction of CYP450 enzyme. |
Supraventricular tachyarrhythmia [BC81]
|
[48] |
Fostamatinib |
DM6AUHV
|
Moderate |
Increased metabolism of Butabarbital caused by Fostamatinib mediated induction of CYP450 enzyme. |
Thrombocytopenia [3B64]
|
[147] |
Apixaban |
DM89JLN
|
Moderate |
Increased metabolism of Butabarbital caused by Apixaban mediated induction of CYP450 enzyme. |
Thrombosis [DB61-GB90]
|
[148] |
Brilinta |
DMBR01X
|
Moderate |
Increased metabolism of Butabarbital caused by Brilinta mediated induction of CYP450 enzyme. |
Thrombosis [DB61-GB90]
|
[111] |
Dicumarol |
DMFQCB1
|
Major |
Increased metabolism of Butabarbital caused by Dicumarol mediated induction of CYP450 enzyme. |
Thrombosis [DB61-GB90]
|
[149] |
Cabozantinib |
DMIYDT4
|
Moderate |
Increased metabolism of Butabarbital caused by Cabozantinib mediated induction of CYP450 enzyme. |
Thyroid cancer [2D10]
|
[150] |
Tizanidine |
DMR2IQ4
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Tizanidine. |
Tonus and reflex abnormality [MB47]
|
[151] |
Sirolimus |
DMGW1ID
|
Moderate |
Increased metabolism of Butabarbital caused by Sirolimus mediated induction of CYP450 enzyme. |
Transplant rejection [NE84]
|
[12] |
Tacrolimus |
DMZ7XNQ
|
Moderate |
Increased metabolism of Butabarbital caused by Tacrolimus mediated induction of CYP450 enzyme. |
Transplant rejection [NE84]
|
[12] |
Saxagliptin |
DMGXENV
|
Moderate |
Increased metabolism of Butabarbital caused by Saxagliptin mediated induction of CYP450 enzyme. |
Type 2 diabetes mellitus [5A11]
|
[152] |
Linagliptin |
DMWFJTR
|
Moderate |
Increased metabolism of Butabarbital caused by Linagliptin mediated induction of CYP450 enzyme. |
Type 2 diabetes mellitus [5A11]
|
[153] |
Elagolix |
DMB2C0E
|
Moderate |
Increased metabolism of Butabarbital caused by Elagolix mediated induction of CYP450 enzyme. |
Uterine fibroid [2E86]
|
[154] |
Triamcinolone |
DM98IXF
|
Moderate |
Increased metabolism of Butabarbital caused by Triamcinolone mediated induction of CYP450 enzyme. |
Vasomotor/allergic rhinitis [CA08]
|
[44] |
Cetirizine |
DMOMP9U
|
Moderate |
Additive CNS depression effects by the combination of Butabarbital and Cetirizine. |
Vasomotor/allergic rhinitis [CA08]
|
[155] |
Disopyramide |
DM5SYZP
|
Moderate |
Increased metabolism of Butabarbital caused by Disopyramide mediated induction of CYP450 enzyme. |
Ventricular tachyarrhythmia [BC71]
|
[156] |
Propafenone |
DMPIBJK
|
Minor |
Increased metabolism of Butabarbital caused by Propafenone. |
Ventricular tachyarrhythmia [BC71]
|
[157] |
----------- |
|
|
|
|
|