Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6Y3A0)

• Drug Name: GALLICACID Drug Info
• Synonyms: Gallic acid; 3,4,5-Trihydroxybenzoic acid; 149-91-7; gallate; Benzoic acid, 3,4,5-trihydroxy-; Gallic acid, tech.; GALOP; Pyrogallol-5-carboxylic acid; Kyselina gallova; HSDB 2117; 3,4,5-Trihydroxybenzoate; CCRIS 5523; Kyselina gallova [Czech]; Gallic acid polymer; UNII-632XD903SP; NSC 674319; Gallicum acidum; CHEBI:30778; AI3-16412; Kyselina 3,4,5-trihydroxybenzoova; EINECS 205-749-9; NSC 20103; BRN 2050274; GALLIC ACID ANHYDROUS; Kyselina 3,4,5-trihydroxybenzoova [Czech]; CHEMBL288114; LNTHITQWFMADLM-UHFFFAOYSA-N; 632XD903SP

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 370
  ChEBI ID: CHEBI:30778
  CAS Number: CAS 149-91-7
  TTD Drug ID: DM6Y3A0

Molecule-Related Drug Atlas

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[11]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting P-selectin (SELP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Crizanlizumab	DMAHOVJ	Vaso-occlusive crisis	BE2Y	Approved	[13]
GMI-1070	DMJ432G	Asthma	CA23	Phase 3	[14]
Inclacumab	DMXV94M	Sickle-cell disorder	3A51	Phase 3	[15]
CY-1503	DML906E	Hypertension	BA00-BA04	Phase 2/3	[16]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[3]
SelG1	DMTQ2K0	Vaso-occlusive crisis	BE2Y	Phase 2	[17]
RPSGL-Ig	DM0BFJ5	Delayed graft function	4B24.0	Phase 2	[18]
PSI-697	DM75FWO	Atherosclerosis	BD40	Phase 1	[19]
CDP-850	DMWHQM3	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[20]
CY-1787	DMWY2NT	Allergy	4A80-4A85	Discontinued in Phase 1	[21]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[22]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[22]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[23]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[22]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[24]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[25]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[12]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[8]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[25]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[26]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[27]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[28]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[28]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[29]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[30]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[31]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[32]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[11]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[11]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[2]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[33]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[7]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[34]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[35]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[36]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[6]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[37]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[22]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[38]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[35]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[8]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[2]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[8]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[9]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[39]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[40]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[41]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[42]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[43]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[2]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[45]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[46]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[53]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[56]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[59]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[60]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[64]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[70]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[71]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[72]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[73]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[74]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[75]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[76]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[77]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[83]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[84]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[87]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[88]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[65]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[89]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[93]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[95]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[103]
Fructose	DM43AN2	Vomiting	MD90	Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[105]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[106]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[107]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[115]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[116]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[123]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[125]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[57]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[119]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[135]

Drug(s) Affected By Solute carrier family 12 member 8 (SLC12A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[137]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]

Drug(s) Affected By E3 ubiquitin-protein ligase TM129 (TMEM129)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By CBY1-interacting BAR domain-containing protein 1 (CIBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[151]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By Transmembrane protein 218 (TMEM218)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By GTP-binding protein 10 (GTPBP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Endosome/lysosome-associated apoptosis and autophagy regulator family member 2 (ELAPOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[163]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Transmembrane protein 250 (TMEM250)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[164]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[164]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Thymidine kinase 2, mitochondrial (TK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[166]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[172]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Transcription elongation factor SPT5 (SUPT5H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Basic helix-loop-helix ARNT-like protein 1 (BMAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[178]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By TNF receptor-associated factor 5 (TRAF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[187]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[188]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]

Drug(s) Affected By AP-3 complex subunit delta-1 (AP3D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[190]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[192]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]

Drug(s) Affected By Synaptojanin-2 (SYNJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[201]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]

Drug(s) Affected By Nuclear valosin-containing protein-like (NVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[209]

Drug(s) Affected By RNA binding protein fox-1 homolog 2 (RBFOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[210]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[211]

Drug(s) Affected By Cochlin (COCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[137]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[137]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[137]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]

Drug(s) Affected By Epsilon-sarcoglycan (SGCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[210]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[210]

Drug(s) Affected By AP-1 complex subunit gamma-1 (AP1G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Unconventional myosin-Ib (MYO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[219]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Nardilysin (NRDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[221]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[221]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[222]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[221]

Drug(s) Affected By Origin recognition complex subunit 4 (ORC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[225]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Adhesion G protein-coupled receptor B2 (ADGRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]

Drug(s) Affected By HMG box-containing protein 1 (HBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Beta-1,4-galactosyltransferase 4 (B4GALT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By Protein diaphanous homolog 1 (DIAPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[237]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]

Drug(s) Affected By Selenoprotein F (SELENOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[239]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[241]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[242]

Drug(s) Affected By Catenin delta-1 (CTNND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]

Drug(s) Affected By Protein diaphanous homolog 2 (DIAPH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[247]

Drug(s) Affected By GATOR1 complex protein DEPDC5 (DEPDC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]

Drug(s) Affected By Autophagy-related protein 13 (ATG13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[251]

Drug(s) Affected By ICOS ligand (ICOSLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[254]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[231]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By Reticulon-2 (RTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 1 (NDUFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Bis(monoacylglycero)phosphate synthase CLN5 (CLN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By E3 SUMO-protein ligase PIAS2 (PIAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[256]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[257]

Drug(s) Affected By Tetraspanin-9 (TSPAN9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Regulator of G-protein signaling 20 (RGS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[259]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[210]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 6 (MAP3K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[261]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[265]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[268]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By Myoglobin (MB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[274]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[275]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[268]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[275]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[277]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[275]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[278]

Drug(s) Affected By Calpain small subunit 1 (CAPNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[285]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[286]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[287]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]

Drug(s) Affected By Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[291]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[292]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]

Drug(s) Affected By Tropomyosin alpha-3 chain (TPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[294]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[295]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[301]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[302]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[314]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[317]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[318]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[321]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[322]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[323]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[324]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[325]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[326]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[327]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[328]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[329]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[330]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[331]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[329]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, muscle type (PFKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[333]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[332]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[334]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[335]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[336]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Selenium	DM25CGV	N. A.	N. A.	Approved	[338]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[345]

Drug(s) Affected By Porphobilinogen deaminase (HMBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[346]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[348]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[349]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[350]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[79]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[79]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[351]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[354]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[355]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[362]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[363]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[312]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[366]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[368]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[65]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[368]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[369]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[370]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[371]

Drug(s) Affected By Solute carrier family 35 member E2B (SLC35E2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Zinc finger protein GLI2 (GLI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase F (PTPRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[377]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[378]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[380]

Drug(s) Affected By Protein 4.1 (EPB41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[381]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Haloperidol	DM96SE0	Delirium		Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[383]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]

Drug(s) Affected By Glycogen synthase, muscle (GYS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[385]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[57]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[387]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[389]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[389]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Selenium	DM25CGV	N. A.	N. A.	Approved	[338]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[393]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[369]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[394]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[395]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]

Drug(s) Affected By POU domain, class 2, transcription factor 1 (POU2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[398]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[399]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[397]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[401]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[402]

Drug(s) Affected By Folate receptor alpha (FOLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[403]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[404]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[405]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[273]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[406]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[407]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[409]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[410]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[411]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[412]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[413]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[414]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[415]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[417]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[418]
Almogran	DM7I64Z	Migraine	8A80	Approved	[419]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[422]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[423]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 1 (ATP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[261]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[220]

Drug(s) Affected By Cation-dependent mannose-6-phosphate receptor (M6PR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[424]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[425]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[426]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]

Drug(s) Affected By Calpastatin (CAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[427]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[235]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[231]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[429]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[394]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[429]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[433]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[429]

Drug(s) Affected By Trifunctional purine biosynthetic protein adenosine-3 (GART)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[434]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[292]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By NAD-dependent malic enzyme, mitochondrial (ME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[435]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[437]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]

Drug(s) Affected By Protein kinase C eta type (PRKCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[440]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Indomethacin	DMSC4A7	Bursitis		Approved	[441]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[153]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[445]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[446]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[447]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[448]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[449]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[451]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[452]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[453]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[454]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[445]

Drug(s) Affected By Myeloid zinc finger 1 (MZF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[455]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Elongation factor 1-delta (EEF1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[456]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[457]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[459]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[416]

Drug(s) Affected By Heme oxygenase 2 (HMOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[187]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[462]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By CAP-Gly domain-containing linker protein 1 (CLIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[465]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[466]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[467]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[468]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[62]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[469]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[470]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[471]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[318]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[472]

Drug(s) Affected By Histamine H1 receptor (HRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[473]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[473]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[57]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[475]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]

Drug(s) Affected By Cystathionine beta-synthase (CBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[478]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[479]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[269]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Gap junction gamma-1 protein (GJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[480]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Guanine nucleotide-binding protein G(olf) subunit alpha (GNAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Azelaic Acid	DMHVL0J	Acne vulgaris	ED80	Approved	[481]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[481]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[482]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[484]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[285]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[485]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[486]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[487]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[488]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[489]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[490]

Drug(s) Affected By Huntingtin (HTT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[491]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[492]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[493]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[494]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[495]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]

Drug(s) Affected By Matrin-3 (MATR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[496]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[364]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[497]

Drug(s) Affected By Melanoma-associated antigen 6 (MAGEA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[498]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[499]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[210]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[210]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[210]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[500]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[501]
Indomethacin	DMSC4A7	Bursitis		Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[503]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[235]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Large ribosomal subunit protein uL18 (RPL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[504]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Large ribosomal subunit protein bL19m (MRPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[505]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[209]

Drug(s) Affected By Transcription initiation factor TFIID subunit 6 (TAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By DNA ligase 4 (LIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[506]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[507]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[508]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[509]

Drug(s) Affected By Cyclin-dependent kinase 7 (CDK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[510]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[511]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[512]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[513]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By Biotin--protein ligase (HLCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[514]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[515]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]

Drug(s) Affected By Palmitoyl-protein thioesterase 1 (PPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[516]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[516]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]

Drug(s) Affected By Transcription activator BRG1 (SMARCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[231]

Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[517]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[517]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Haloperidol	DM96SE0	Delirium		Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[269]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[518]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[519]

Drug(s) Affected By IST1 homolog (IST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[520]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[153]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[151]

Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[354]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[521]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[521]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[354]

Drug(s) Affected By Bax inhibitor 1 (TMBIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[294]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[522]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[505]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[113]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[524]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[524]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[500]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[525]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[526]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[527]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[528]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[60]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[529]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[128]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[530]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[531]

Drug(s) Affected By PR domain zinc finger protein 15 (PRDM15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[532]

Drug(s) Affected By Uncharacterized protein C21orf58 (C21ORF58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 4 (ARPC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[533]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[534]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[535]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[536]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[537]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[538]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[539]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[540]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[541]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[506]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[542]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[543]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[544]
Bortezomib	DMNO38U	Leukemia		Approved	[179]

Drug(s) Affected By Ras-related protein Rap-1b (RAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[545]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[546]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[547]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[548]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[550]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[551]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[552]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[553]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[554]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[555]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[556]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[558]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[549]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[559]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[506]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[560]

Drug(s) Affected By Large ribosomal subunit protein eL32 (RPL32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[561]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[520]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[562]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[563]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[565]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[566]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[567]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[568]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[559]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[541]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[569]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[561]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[570]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[424]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[571]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[408]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]

Drug(s) Affected By Matrix-remodeling-associated protein 7 (MXRA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Peripheral myelin protein 22 (PMP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[572]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[573]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[576]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]

Drug(s) Affected By D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Dynamin-1 (DNM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]

Drug(s) Affected By CTD small phosphatase-like protein 2 (CTDSPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By 3-ketodihydrosphingosine reductase (KDSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[225]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[577]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[578]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[579]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[581]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[582]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[583]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[53]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[490]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[59]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[584]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[111]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[585]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[65]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[587]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[294]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[496]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]

Drug(s) Affected By Golgin subfamily A member 3 (GOLGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[378]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]

Drug(s) Affected By Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[210]

Drug(s) Affected By Secernin-3 (SCRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[458]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[153]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[588]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[247]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Interferon-related developmental regulator 2 (IFRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[589]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase eta (PTPRJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]

Drug(s) Affected By Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[590]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[591]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[592]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[593]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[594]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[595]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[566]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[596]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[490]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[597]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[350]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[598]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[433]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[600]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[601]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[602]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[603]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[604]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[408]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[605]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[606]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[607]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]

Drug(s) Affected By Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[555]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[424]

Drug(s) Affected By Cold-inducible RNA-binding protein (CIRBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[608]

Drug(s) Affected By Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[609]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[609]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[610]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[503]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[611]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]

Drug(s) Affected By Importin subunit beta-1 (KPNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[612]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[612]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]

Drug(s) Affected By Histone-lysine N-methyltransferase SETDB1 (SETDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[613]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[614]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[615]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[545]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[616]

Drug(s) Affected By RNA-binding protein with serine-rich domain 1 (RNPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[617]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[618]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[619]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]

Drug(s) Affected By Protein transport protein Sec23B (SEC23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]

Drug(s) Affected By Transcriptional enhancer factor TEF-4 (TEAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[620]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[621]

Drug(s) Affected By Ras-related protein Rab-30 (RAB30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[622]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]

Drug(s) Affected By Synaptophysin-like protein 1 (SYPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[209]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[623]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[624]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[625]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[626]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[626]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[627]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[628]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[618]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[630]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[578]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[293]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[631]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[479]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[231]

Drug(s) Affected By Protein moonraker (KIAA0753)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[497]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[632]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase (ALG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]

Drug(s) Affected By NADH dehydrogenase (NDUFAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]

Drug(s) Affected By Glucose-fructose oxidoreductase domain-containing protein 2 (GFOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[608]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit TIM50 (TIMM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[635]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Neuritin-like protein (NRN1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Beta-alanine-activating enzyme (AASDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Protein Hikeshi (HIKESHI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By EARP and GARP complex-interacting protein 1 (EIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[589]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Puratrophin-1 (PLEKHG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]

Drug(s) Affected By Histone H2B type 2-F (H2BC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[383]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]

Drug(s) Affected By Protein odr-4 homolog (ODR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[638]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]

Drug(s) Affected By Centrosomal protein of 162 kDa (CEP162)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[225]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Ribonuclease H2 subunit B (RNASEH2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[51]

Drug(s) Affected By Triple QxxK/R motif-containing protein (TRIQK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]

Drug(s) Affected By Kynurenine formamidase (AFMID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[639]

Drug(s) Affected By NADH-cytochrome b5 reductase 2 (CYB5R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]

Drug(s) Affected By AMMECR1-like protein (AMMECR1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[220]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Centriole, cilia and spindle-associated protein (CCSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Acyl-CoA dehydrogenase family member 10 (ACAD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]

Drug(s) Affected By DNA oxidative demethylase ALKBH2 (ALKBH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[641]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Phostensin (PPP1R18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[642]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Ankyrin repeat domain-containing protein 11 (ANKRD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[405]

Drug(s) Affected By Cytochrome P450 20A1 (CYP20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]

Drug(s) Affected By Transmembrane protein 205 (TMEM205)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[643]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[589]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[535]

Drug(s) Affected By Lysocardiolipin acyltransferase 1 (LCLAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[532]

Drug(s) Affected By GRB10-interacting GYF protein 2 (GIGYF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Ceramide synthase 6 (CERS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[644]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[247]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By NF-X1-type zinc finger protein NFXL1 (NFXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[138]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[645]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[646]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[222]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[647]

Drug(s) Affected By Uncharacterized protein NKAPD1 (NKAPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[136]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[222]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By LanC-like protein 3 (LANCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[621]

Drug(s) Affected By Serine/threonine-protein kinase Nek10 (NEK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[648]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By MOB kinase activator 3C (MOB3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 25 (MED25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By CXXC-type zinc finger protein 5 (CXXC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]

Drug(s) Affected By D-glutamate cyclase, mitochondrial (DGLUCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[649]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[620]

Drug(s) Affected By Protein MON2 homolog (MON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[424]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[225]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By BRCA2-interacting transcriptional repressor EMSY (EMSY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[650]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By Multiple epidermal growth factor-like domains protein 8 (MEGF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]

Drug(s) Affected By Dipeptidyl peptidase 9 (DPP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]

Drug(s) Affected By Sodium/hydrogen exchanger 9B2 (SLC9B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[651]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]

Drug(s) Affected By Tax1-binding protein 1 (TAX1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[635]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[652]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[653]

Drug(s) Affected By Peptidyl-tRNA hydrolase (PTRH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Nostrin (NOSTRIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]

Drug(s) Affected By Neuron navigator 3 (NAV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]

Drug(s) Affected By Coiled-coil domain-containing protein 117 (CCDC117)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[654]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Polycomb group protein ASXL1 (ASXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[655]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[656]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]

Drug(s) Affected By Methionine-R-sulfoxide reductase B3 (MSRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]

Drug(s) Affected By Protein AMN1 homolog (AMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[657]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[658]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Fanconi anemia group M protein (FANCM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[578]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[659]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Centrosomal protein CEP57L1 (CEP57L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Abl interactor 1 (ABI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[660]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Adhesion G-protein coupled receptor G2 (ADGRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Beta/gamma crystallin domain-containing protein 2 (CRYBG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[661]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[662]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[663]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (GBGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[192]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[664]

Drug(s) Affected By Male-specific lethal 3 homolog (MSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[153]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[665]

Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 7 (CPSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[535]

Drug(s) Affected By PACRG-like protein (PACRGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[666]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Ankyrin repeat domain-containing protein 42 (ANKRD42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[192]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Interleukin-17 receptor C (IL17RC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[667]

Drug(s) Affected By Inactive C-alpha-formylglycine-generating enzyme 2 (SUMF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]

Drug(s) Affected By SLAIN motif-containing protein 1 (SLAIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[663]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By B-cell scaffold protein with ankyrin repeats (BANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By Protein FAM13C (FAM13C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[153]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]

Drug(s) Affected By Histone-lysine N-methyltransferase 2C (KMT2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[322]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[668]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[669]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[670]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By sn-1-specific diacylglycerol lipase ABHD11 (ABHD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[210]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[260]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By V-type proton ATPase subunit e 2 (ATP6V0E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[642]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Iron-sulfur cluster transfer protein NUBPL (NUBPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]

Drug(s) Affected By tRNA methyltransferase 10 homolog A (TRMT10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[136]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By TBC1 domain family member 15 (TBC1D15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]

Drug(s) Affected By PDZ domain-containing protein GIPC3 (GIPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[621]

Drug(s) Affected By Protein prune homolog 2 (PRUNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[671]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]

Drug(s) Affected By DDB1- and CUL4-associated factor 4 (DCAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[622]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[189]

Drug(s) Affected By Transmembrane protein 170A (TMEM170A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[642]

Drug(s) Affected By Cohesin subunit SA-1 (STAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[672]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[655]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 8-like protein 1 (TNFAIP8L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By Cholesterol transporter ABCA5 (ABCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[673]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[674]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Autism susceptibility gene 2 protein (AUTS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[675]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[676]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]

Drug(s) Affected By Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[137]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[137]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Microprocessor complex subunit DGCR8 (DGCR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[677]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[496]

Drug(s) Affected By E3 ubiquitin-protein ligase rififylin (RFFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[137]

Drug(s) Affected By ATP-dependent RNA helicase DDX1 (DDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[303]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[191]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Histone acetyltransferase KAT6A (KAT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[650]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[458]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[141]

Drug(s) Affected By N-alpha-acetyltransferase 80 (NAA80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Bortezomib	DMNO38U	Leukemia		Approved	[678]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Lipoma-preferred partner (LPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[679]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[679]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[230]

Drug(s) Affected By Transcription factor E2F7 (E2F7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[578]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[51]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[659]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[642]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[681]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[682]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Phosphotriesterase-related protein (PTER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]

Drug(s) Affected By Atypical kinase COQ8B, mitochondrial (COQ8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[589]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[646]

Drug(s) Affected By ELMO domain-containing protein 3 (ELMOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Endonuclease 8-like 1 (NEIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[683]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[621]

Drug(s) Affected By Serine dehydratase-like (SDSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[684]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]

Drug(s) Affected By RUS family member 1 (RUSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Haloperidol	DM96SE0	Delirium		Approved	[294]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[294]

Drug(s) Affected By Vesicle-trafficking protein SEC22a (SEC22A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Beta-1,3-galactosyltransferase 6 (B3GALT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By CCR4-NOT transcription complex subunit 6-like (CNOT6L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[211]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By Guanine nucleotide exchange factor C9orf72 (C9ORF72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Dedicator of cytokinesis protein 7 (DOCK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[608]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[686]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[163]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[152]

Drug(s) Affected By Trafficking protein particle complex subunit 9 (TRAPPC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Leucine-rich repeat-containing protein 37B (LRRC37B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[640]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Formin-binding protein 1 (FNBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[533]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Ribosomal protein S6 kinase delta-1 (RPS6KC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By T-box transcription factor TBX15 (TBX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[383]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Integrator complex subunit 14 (INTS14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[687]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Tubulin-folding cofactor B (TBCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[294]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[621]

Drug(s) Affected By Ribonucleases P/MRP protein subunit POP1 (POP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[688]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[689]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[434]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[654]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[690]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By Homeobox protein Meis3 (MEIS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Ataxin-2 (ATXN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[691]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[642]

Drug(s) Affected By Nucleosome assembly protein 1-like 4 (NAP1L4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[692]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[694]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[695]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[696]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]

Drug(s) Affected By ATP-dependent RNA helicase DDX50 (DDX50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Protein FAM110A (FAM110A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[359]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[589]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Small membrane A-kinase anchor protein (C2ORF88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]

Drug(s) Affected By TERF1-interacting nuclear factor 2 (TINF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[404]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[404]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[404]
Pyrrolidine dithiocarbamate	DM5ZAS6	Discovery agent	N.A.	Investigative	[697]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A23 (SLC25A23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[698]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[699]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[699]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[700]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[589]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Transmembrane protein 106C (TMEM106C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Intraflagellar transport protein 27 homolog (IFT27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By E3 ubiquitin-protein ligase TRAIP (TRAIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[701]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[702]

Drug(s) Affected By Kanadaptin (SLC4A1AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[665]

Drug(s) Affected By AP-1 complex subunit mu-1 (AP1M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[703]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Emopamil-binding protein-like (EBPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By Hyccin (HYCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[704]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[705]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[458]

Drug(s) Affected By ATP-binding cassette sub-family A member 2 (ABCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[706]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[707]

Drug(s) Affected By tRNA pseudouridine(38/39) synthase (PUS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[89]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Oxysterol-binding protein-related protein 6 (OSBPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[708]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 1 (NLRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[709]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[709]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[710]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]

Drug(s) Affected By Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[711]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[712]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[222]

Drug(s) Affected By NIF3-like protein 1 (NIF3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[713]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[691]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX47 (DDX47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[142]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Carbohydrate sulfotransferase 8 (CHST8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Protein ARV1 (ARV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By STING ER exit protein (STEEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Lipid droplet-associated hydrolase (LDAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By N-alpha-acetyltransferase 60 (NAA60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]

Drug(s) Affected By tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial (METTL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Gem-associated protein 7 (GEMIN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM45 (TRIM45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]

Drug(s) Affected By COP9 signalosome complex subunit 7b (COPS7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Ribitol 5-phosphate transferase FKRP (FKRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By 2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[714]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]

Drug(s) Affected By Ribonucleoprotein PTB-binding 2 (RAVER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[659]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[648]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[153]

Drug(s) Affected By Calcium-independent phospholipase A2-gamma (PNPLA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM36 (TRIM36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[219]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[715]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[716]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Bortezomib	DMNO38U	Leukemia		Approved	[717]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[718]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[719]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[718]

Drug(s) Affected By PR domain zinc finger protein 10 (PRDM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[637]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[192]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By PR domain zinc finger protein 5 (PRDM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[720]

Drug(s) Affected By Integral membrane protein 2C (ITM2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[721]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By Sphingosine kinase 2 (SPHK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[722]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[436]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[723]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]

Drug(s) Affected By Transmembrane 7 superfamily member 3 (TM7SF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[724]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[649]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[725]

Drug(s) Affected By BMP-2-inducible protein kinase (BMP2K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Indomethacin	DMSC4A7	Bursitis		Approved	[726]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[235]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]

Drug(s) Affected By PI-PLC X domain-containing protein 1 (PLCXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[269]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Double-stranded RNA-binding protein Staufen homolog 2 (STAU2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[620]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By SPATS2-like protein (SPATS2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[727]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]

Drug(s) Affected By Syntabulin (SYBU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[166]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Homeobox protein Hox-C10 (HOXC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[584]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Anaphase-promoting complex subunit 11 (ANAPC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[678]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Proline-rich protein 13 (PRR13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[639]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT3 (FLRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[728]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[233]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]

Drug(s) Affected By COMM domain-containing protein 9 (COMMD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[646]

Drug(s) Affected By RAB11-binding protein RELCH (RELCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[174]

Drug(s) Affected By Inhibitor of Bruton tyrosine kinase (IBTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[464]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[729]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Kelch-like protein 13 (KLHL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[229]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[620]

Drug(s) Affected By Calcium channel flower homolog (CACFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By LIM domain and actin-binding protein 1 (LIMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[730]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[258]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]

Drug(s) Affected By Inositol hexakisphosphate kinase 2 (IP6K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[731]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[639]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]

Drug(s) Affected By Nuclear prelamin A recognition factor (NARF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]

Drug(s) Affected By Enolase-phosphatase E1 (ENOPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[210]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[192]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Methyl-CpG-binding domain protein 1 (MBD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[732]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[733]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]

Drug(s) Affected By CCR4-NOT transcription complex subunit 7 (CNOT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[376]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[734]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[258]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By ADP-ribosylation factor-binding protein GGA1 (GGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[240]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[563]

Drug(s) Affected By F-box/WD repeat-containing protein 11 (FBXW11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Zinc finger protein Helios (IKZF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[476]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[130]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[236]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[735]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[153]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[709]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[736]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[737]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[184]

Drug(s) Affected By Sorting nexin-12 (SNX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[545]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[157]

Drug(s) Affected By Rab-like protein 2B (RABL2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[424]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[155]

Drug(s) Affected By TBC1 domain family member 2B (TBC1D2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[253]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[145]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[200]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[738]

Drug(s) Affected By Dynamin-3 (DNM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[645]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[657]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[149]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[98]

Drug(s) Affected By Bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[606]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[728]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[499]

Drug(s) Affected By Lipoyl amidotransferase LIPT1, mitochondrial (LIPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[739]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[535]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[740]

Drug(s) Affected By UDP-N-acetylglucosamine transporter (SLC35A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[465]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[141]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[741]

Drug(s) Affected By Disco-interacting protein 2 homolog C (DIP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[461]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[742]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[171]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[636]

Drug(s) Affected By BTB/POZ domain-containing protein 3 (BTBD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[743]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[496]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[634]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[744]

Drug(s) Affected By START domain-containing protein 10 (STARD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[745]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[746]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[231]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[194]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[137]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 3 (TACC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[356]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]

Drug(s) Affected By Testis-expressed protein 264 (TEX264)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[150]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[2]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[2]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[2]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[2]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[2]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[2]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[2]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[2]
P-selectin (SELP)	TTE5VG0	LYAM3_HUMAN	Inhibitor	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2-oxoglutarate and iron-dependent oxygenase JMJD4 (JMJD4)	OTYZGH63	JMJD4_HUMAN	Gene/Protein Processing	[4]
3-ketodihydrosphingosine reductase (KDSR)	OTCIES3H	KDSR_HUMAN	Gene/Protein Processing	[4]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[4]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[5]
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Gene/Protein Processing	[4]
Abl interactor 1 (ABI1)	OT5H4M62	ABI1_HUMAN	Gene/Protein Processing	[4]
Actin-binding protein WASF1	OT8C9841	WASF1_HUMAN	Gene/Protein Processing	[4]
Actin-related protein 2/3 complex subunit 4 (ARPC4)	OT0ZE01B	ARPC4_HUMAN	Gene/Protein Processing	[4]
Activating molecule in BECN1-regulated autophagy protein 1 (AMBRA1)	OTY0YGT9	AMRA1_HUMAN	Gene/Protein Processing	[4]
Acyl-CoA dehydrogenase family member 10 (ACAD10)	OTFAG3M0	ACD10_HUMAN	Gene/Protein Processing	[4]

References

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