Details of the Drug Combination

General Information of Drug Combination (ID: DC70MC4)

Drug Combination Name

Topotecan Dasatinib

Indication

Disease Entry	Status	REF
Malignant melanoma	Investigative	[1]

Component Drugs

Topotecan DMP6G8T

Dasatinib DMJV2EK

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: UACC62

Zero Interaction Potency (ZIP) Score: 0.7

Bliss Independence Score: 0.3

Loewe Additivity Score: 1.06

LHighest Single Agent (HSA) Score: 1.13

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Topotecan

Disease Entry	ICD 11	Status	REF
Central nervous system neoplasm	N.A.	Approved	[2]
Cervical cancer	2C77.0	Approved	[2]
Epithelial ovarian cancer	2B5D	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Ovarian cancer	2C73	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Approved	[4]
Small-cell lung cancer	2C25.Y	Phase 1	[5]
Neuroblastoma	2D11.2	Investigative	[2]

Topotecan Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[13]
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Topotecan Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[14]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[15]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[16]
Multidrug and toxin extrusion protein 1 (SLC47A1)	DTZGT0P	S47A1_HUMAN	Substrate	[17]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[18]
Multidrug and toxin extrusion protein 2 (SLC47A2)	DT3TX4H	S47A2_HUMAN	Substrate	[17]
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⏷ Show the Full List of 6 DTP(s)

Topotecan Interacts with 246 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[19]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Response To Substance	[20]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[21]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[22]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[23]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[24]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Phosphorylation	[25]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[26]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[27]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[23]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[28]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[28]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[29]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[23]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[27]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Cleavage	[19]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[26]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[30]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Increases Cleavage	[30]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[28]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[19]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[10]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[19]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Decreases Expression	[28]
Bcl-2-like protein 12 (BCL2L12)	OTS6IFZY	B2L12_HUMAN	Decreases Expression	[27]
Three-prime repair exonuclease 1 (TREX1)	OTQG7K12	TREX1_HUMAN	Increases Expression	[25]
Histone H2A.V (H2AZ2)	OT0I5H2P	H2AV_HUMAN	Affects Response To Substance	[11]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	OT0KMIYQ	RIPK2_HUMAN	Affects Response To Substance	[11]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA)	OT0LHOZB	ODBA_HUMAN	Affects Response To Substance	[11]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Affects Response To Substance	[11]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[11]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Affects Response To Substance	[11]
Tetraspanin-8 (TSPAN8)	OT1F68WQ	TSN8_HUMAN	Affects Response To Substance	[11]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)	OT1G9297	TFIP8_HUMAN	Affects Response To Substance	[11]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Affects Response To Substance	[11]
ATP-binding cassette sub-family D member 3 (ABCD3)	OT2PITLX	ABCD3_HUMAN	Affects Response To Substance	[11]
Optineurin (OPTN)	OT2UXWH9	OPTN_HUMAN	Affects Response To Substance	[11]
Epidermal growth factor-like protein 6 (EGFL6)	OT331X59	EGFL6_HUMAN	Decreases Response To Substance	[12]
Protein FAM171A1 (FAM171A1)	OT33BHEP	F1711_HUMAN	Affects Response To Substance	[11]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Affects Response To Substance	[11]
Cleavage stimulation factor subunit 2 tau variant (CSTF2T)	OT3IKRL2	CSTFT_HUMAN	Affects Response To Substance	[11]
Fatty acid CoA ligase Acsl3 (ACSL3)	OT3MWER1	ACSL3_HUMAN	Affects Response To Substance	[11]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Affects Response To Substance	[11]
Platelet-derived growth factor C (PDGFC)	OT3ZJ0XU	PDGFC_HUMAN	Affects Response To Substance	[11]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4)	OT403QC1	PIN4_HUMAN	Affects Response To Substance	[11]
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)	OT45AHMB	JIP4_HUMAN	Affects Response To Substance	[11]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Affects Response To Substance	[11]
Sorcin (SRI)	OT4R3EAC	SORCN_HUMAN	Affects Response To Substance	[11]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)	OT4RF9Z4	PDE8A_HUMAN	Affects Response To Substance	[11]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Affects Response To Substance	[11]
Polyphosphoinositide phosphatase (FIG4)	OT501PY9	FIG4_HUMAN	Affects Response To Substance	[11]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Affects Response To Substance	[11]
RAC-gamma serine/threonine-protein kinase (AKT3)	OT5M2LFI	AKT3_HUMAN	Affects Response To Substance	[11]
Leukocyte elastase inhibitor (SERPINB1)	OT5RDUFO	ILEU_HUMAN	Affects Response To Substance	[11]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Response To Substance	[12]
Transcription activator BRG1 (SMARCA4)	OT68WOPQ	SMCA4_HUMAN	Affects Response To Substance	[11]
Metal cation symporter ZIP8 (SLC39A8)	OT6C6MNV	S39A8_HUMAN	Affects Response To Substance	[11]
Regulator of G-protein signaling 20 (RGS20)	OT6CGYHW	RGS20_HUMAN	Affects Response To Substance	[11]
BTB/POZ domain-containing protein KCTD3 (KCTD3)	OT6EGR42	KCTD3_HUMAN	Affects Response To Substance	[11]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Affects Response To Substance	[11]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Affects Response To Substance	[11]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)	OT6MFOWF	TGM2_HUMAN	Affects Response To Substance	[11]
G-protein-signaling modulator 2 (GPSM2)	OT6RPMRM	GPSM2_HUMAN	Affects Response To Substance	[11]
Cytochrome b5 (CYB5A)	OT6SN4RM	CYB5_HUMAN	Affects Response To Substance	[11]
Ankycorbin (RAI14)	OT6USGBK	RAI14_HUMAN	Affects Response To Substance	[11]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Affects Response To Substance	[11]
Replication protein A 70 kDa DNA-binding subunit (RPA1)	OT76POLP	RFA1_HUMAN	Affects Response To Substance	[11]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Affects Response To Substance	[11]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Affects Response To Substance	[11]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Affects Response To Substance	[11]
Forkhead box protein D1 (FOXD1)	OT80PRHS	FOXD1_HUMAN	Affects Response To Substance	[11]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Affects Response To Substance	[11]
Raftlin (RFTN1)	OT8875JE	RFTN1_HUMAN	Affects Response To Substance	[11]
Mesoderm-specific transcript homolog protein (MEST)	OT8Q4U8Y	MEST_HUMAN	Affects Response To Substance	[11]
Four-jointed box protein 1 (FJX1)	OT8SVTSS	FJX1_HUMAN	Affects Response To Substance	[11]
Leptin receptor (LEPR)	OT9H7G0C	LEPR_HUMAN	Affects Response To Substance	[11]
Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)	OT9KXWE7	CAMP2_HUMAN	Affects Response To Substance	[11]
Oxidoreductase HTATIP2 (HTATIP2)	OT9MZ4QO	HTAI2_HUMAN	Affects Response To Substance	[11]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Affects Response To Substance	[11]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)	OTA2TBWS	HMGN3_HUMAN	Affects Response To Substance	[11]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)	OTA6ICI2	NUD4B_HUMAN	Affects Response To Substance	[11]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Affects Response To Substance	[11]
Autism susceptibility gene 2 protein (AUTS2)	OTAEXHSC	AUTS2_HUMAN	Affects Response To Substance	[11]
Grancalcin (GCA)	OTAJ7ZHG	GRAN_HUMAN	Affects Response To Substance	[11]
RNA polymerase II elongation factor ELL3 (ELL3)	OTALC1YD	ELL3_HUMAN	Affects Response To Substance	[11]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK)	OTAP5AT3	PTPRK_HUMAN	Affects Response To Substance	[11]
snRNA-activating protein complex subunit 1 (SNAPC1)	OTAPN1NI	SNPC1_HUMAN	Affects Response To Substance	[11]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Affects Response To Substance	[11]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Affects Response To Substance	[11]
Desmoplakin (DSP)	OTB2MOP8	DESP_HUMAN	Affects Response To Substance	[11]
Protein lin-7 homolog C (LIN7C)	OTB3015O	LIN7C_HUMAN	Affects Response To Substance	[11]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL)	OTB3BFCV	HNRDL_HUMAN	Affects Response To Substance	[11]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Affects Response To Substance	[11]
Microtubule-associated tumor suppressor 1 (MTUS1)	OTBPALMU	MTUS1_HUMAN	Affects Response To Substance	[11]
Cilium assembly protein DZIP1 (DZIP1)	OTBVPO66	DZIP1_HUMAN	Affects Response To Substance	[11]
Thiamin pyrophosphokinase 1 (TPK1)	OTCHPUD0	TPK1_HUMAN	Affects Response To Substance	[11]
Cytoskeleton-associated protein 2 (CKAP2)	OTCLTC0J	CKAP2_HUMAN	Affects Response To Substance	[11]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Affects Response To Substance	[11]
Cytochrome c oxidase copper chaperone (COX17)	OTCP4LH2	COX17_HUMAN	Affects Response To Substance	[11]
Tetraspanin-13 (TSPAN13)	OTCS9BZY	TSN13_HUMAN	Affects Response To Substance	[11]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Affects Response To Substance	[11]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Affects Response To Substance	[11]
Keratin, type I cytoskeletal 19 (KRT19)	OTDGDQ75	K1C19_HUMAN	Affects Response To Substance	[11]
Integrin alpha-1 (ITGA1)	OTDITIST	ITA1_HUMAN	Increases Response To Substance	[12]
AP-5 complex subunit mu-1 (AP5M1)	OTDLWEBL	AP5M1_HUMAN	Affects Response To Substance	[11]
Protein eva-1 homolog B (EVA1B)	OTDNAKQD	EVA1B_HUMAN	Affects Response To Substance	[11]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Affects Response To Substance	[11]
Dickkopf-related protein 3 (DKK3)	OTDU94EY	DKK3_HUMAN	Affects Response To Substance	[11]
Ras-related protein Rab-7L1 (RAB29)	OTDZT6LP	RAB7L_HUMAN	Affects Response To Substance	[11]
Short transient receptor potential channel 1 (TRPC1)	OTEEAGLH	TRPC1_HUMAN	Affects Response To Substance	[11]
H(+)/Cl(-) exchange transporter 3 (CLCN3)	OTEEXNMU	CLCN3_HUMAN	Affects Response To Substance	[11]
Secernin-1 (SCRN1)	OTELM5C2	SCRN1_HUMAN	Affects Response To Substance	[11]
NGFI-A-binding protein 1 (NAB1)	OTEWHIZR	NAB1_HUMAN	Affects Response To Substance	[11]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Affects Response To Substance	[11]
Solute carrier family 35 member G2 (SLC35G2)	OTFBVS0P	S35G2_HUMAN	Affects Response To Substance	[11]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Affects Response To Substance	[11]
Multiple C2 and transmembrane domain-containing protein 2 (MCTP2)	OTFMZ8I2	MCTP2_HUMAN	Affects Response To Substance	[11]
Caveolae-associated protein 1 (CAVIN1)	OTFO915U	CAVN1_HUMAN	Affects Response To Substance	[11]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Increases Response To Substance	[12]
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (CSTPP1)	OTFSO3XV	CSTP1_HUMAN	Affects Response To Substance	[11]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Affects Response To Substance	[11]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Affects Response To Substance	[11]
Transmembrane protein 80 (TMEM80)	OTG9D4KX	TMM80_HUMAN	Affects Response To Substance	[11]
Squalene synthase (FDFT1)	OTGDISIT	FDFT_HUMAN	Affects Response To Substance	[11]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Affects Response To Substance	[11]
Cytotoxic granule associated RNA binding protein TIA1 (TIA1)	OTGPN3P8	TIA1_HUMAN	Affects Response To Substance	[11]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Affects Response To Substance	[11]
Sigma intracellular receptor 2 (TMEM97)	OTH76ZWK	SGMR2_HUMAN	Affects Response To Substance	[11]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Affects Response To Substance	[11]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Affects Response To Substance	[11]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Response To Substance	[11]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Affects Response To Substance	[11]
Solute carrier family 38 member 6 (SLC38A6)	OTIC8SHQ	S38A6_HUMAN	Affects Response To Substance	[11]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Affects Response To Substance	[11]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Affects Response To Substance	[11]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Affects Response To Substance	[11]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Affects Response To Substance	[11]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Affects Response To Substance	[11]
Ras-related protein Rab-13 (RAB13)	OTIQ484I	RAB13_HUMAN	Affects Response To Substance	[11]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Response To Substance	[11]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Affects Response To Substance	[11]
Histone deacetylase complex subunit SAP18 (SAP18)	OTJAZWOL	SAP18_HUMAN	Affects Response To Substance	[11]
E3 ubiquitin-protein ligase FANCL (FANCL)	OTJC7QPQ	FANCL_HUMAN	Affects Response To Substance	[11]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Affects Response To Substance	[11]
FERM domain-containing protein 4A (FRMD4A)	OTJDTIK2	FRM4A_HUMAN	Affects Response To Substance	[11]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Affects Response To Substance	[11]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Affects Response To Substance	[11]
Jupiter microtubule associated homolog 2 (JPT2)	OTJGPA4T	JUPI2_HUMAN	Affects Response To Substance	[11]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Affects Response To Substance	[11]
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)	OTKAN9G7	TNF6B_HUMAN	Affects Response To Substance	[11]
Myelin protein zero-like protein 2 (MPZL2)	OTKFNDUI	MPZL2_HUMAN	Affects Response To Substance	[11]
Transmembrane channel-like protein 6 (TMC6)	OTKH50J4	TMC6_HUMAN	Affects Response To Substance	[11]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Affects Response To Substance	[11]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Affects Response To Substance	[11]
Enolase-phosphatase E1 (ENOPH1)	OTKXMWNN	ENOPH_HUMAN	Affects Response To Substance	[11]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)	OTKYMT99	CABYR_HUMAN	Affects Response To Substance	[11]
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)	OTLNA39Z	NMT2_HUMAN	Affects Response To Substance	[11]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Response To Substance	[12]
Ribosome biogenesis protein BOP1 (BOP1)	OTMZMQDO	BOP1_HUMAN	Affects Response To Substance	[11]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)	OTN0K7F3	ERF3B_HUMAN	Affects Response To Substance	[11]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Affects Response To Substance	[11]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Affects Response To Substance	[11]
Epithelial splicing regulatory protein 1 (ESRP1)	OTNCS4SL	ESRP1_HUMAN	Affects Response To Substance	[11]
Radixin (RDX)	OTNSYUN6	RADI_HUMAN	Affects Response To Substance	[11]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1)	OTNYXOZO	KCMA1_HUMAN	Affects Response To Substance	[11]
Paraneoplastic antigen-like protein 8A (PNMA8A)	OTO3F7B0	PNM8A_HUMAN	Affects Response To Substance	[11]
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)	OTO3RO36	GALT1_HUMAN	Affects Response To Substance	[11]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Affects Response To Substance	[11]
Histone-lysine N-methyltransferase KMT5B (KMT5B)	OTOH7G8Q	KMT5B_HUMAN	Affects Response To Substance	[11]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Affects Response To Substance	[11]
GTP cyclohydrolase 1 (GCH1)	OTOZ6NSL	GCH1_HUMAN	Affects Response To Substance	[11]
Unconventional myosin-Id (MYO1D)	OTP2RGPN	MYO1D_HUMAN	Affects Response To Substance	[11]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Affects Response To Substance	[11]
Ras-related protein Rab-20 (RAB20)	OTP9OOVS	RAB20_HUMAN	Affects Response To Substance	[11]
Dual specificity protein phosphatase 3 (DUSP3)	OTPJX9B4	DUS3_HUMAN	Affects Response To Substance	[11]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Affects Response To Substance	[11]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Affects Response To Substance	[11]
Dermatan-sulfate epimerase (DSE)	OTQ108VJ	DSE_HUMAN	Affects Response To Substance	[11]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Affects Response To Substance	[11]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Affects Response To Substance	[11]
Sortilin-related receptor (SORL1)	OTQ8FFNS	SORL_HUMAN	Affects Response To Substance	[11]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Affects Response To Substance	[11]
Ran-specific GTPase-activating protein (RANBP1)	OTQE226K	RANG_HUMAN	Affects Response To Substance	[11]
MAPK/MAK/MRK overlapping kinase (MOK)	OTQK7M9V	MOK_HUMAN	Affects Response To Substance	[11]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Affects Response To Substance	[11]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Affects Response To Substance	[11]
Keratin, type I cytoskeletal 23 (KRT23)	OTQW6UAG	K1C23_HUMAN	Increases Response To Substance	[12]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Response To Substance	[12]
Large ribosomal subunit protein mL63 (MRPL57)	OTRB659E	RT63_HUMAN	Affects Response To Substance	[11]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Affects Response To Substance	[11]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)	OTRHPFO2	AN32A_HUMAN	Affects Response To Substance	[11]
LIM domain kinase 2 (LIMK2)	OTRJD7VZ	LIMK2_HUMAN	Affects Response To Substance	[11]
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)	OTRN55RE	KCC1A_HUMAN	Affects Response To Substance	[11]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Affects Response To Substance	[11]
Lysyl oxidase homolog 2 (LOXL2)	OTRT46B5	LOXL2_HUMAN	Affects Response To Substance	[11]
Arginine and glutamate-rich protein 1 (ARGLU1)	OTRVRZ4Z	ARGL1_HUMAN	Affects Response To Substance	[11]
Dr1-associated corepressor (DRAP1)	OTRWLF6D	NC2A_HUMAN	Affects Response To Substance	[11]
Latent-transforming growth factor beta-binding protein 2 (LTBP2)	OTS88GSD	LTBP2_HUMAN	Affects Response To Substance	[11]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Affects Response To Substance	[11]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Affects Response To Substance	[11]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Response To Substance	[12]
GTP-binding protein SAR1a (SAR1A)	OTSSRVGV	SAR1A_HUMAN	Affects Response To Substance	[11]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Affects Response To Substance	[11]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Response To Substance	[12]
DNA-binding protein SATB1 (SATB1)	OTT7SUVW	SATB1_HUMAN	Affects Response To Substance	[11]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Affects Response To Substance	[11]
KH domain-containing RNA-binding protein QKI (QKI)	OTTAUGLB	QKI_HUMAN	Affects Response To Substance	[11]
Cullin-4A (CUL4A)	OTTBV70J	CUL4A_HUMAN	Affects Response To Substance	[11]
Homeobox protein Hox-B2 (HOXB2)	OTTD6HMV	HXB2_HUMAN	Affects Response To Substance	[11]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Decreases Response To Substance	[12]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Affects Response To Substance	[11]
Nuclear receptor-interacting protein 3 (NRIP3)	OTU15GMK	NRIP3_HUMAN	Affects Response To Substance	[11]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA)	OTUOO2XS	CSF2R_HUMAN	Affects Response To Substance	[11]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Affects Response To Substance	[11]
General transcription factor II-I (GTF2I)	OTUYL1TQ	GTF2I_HUMAN	Affects Response To Substance	[11]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Affects Response To Substance	[11]
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)	OTV3T64P	FGD1_HUMAN	Affects Response To Substance	[11]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Decreases Response To Substance	[12]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)	OTVIHD77	MACF1_HUMAN	Affects Response To Substance	[11]
Serine protease FAM111A (FAM111A)	OTVLARLG	F111A_HUMAN	Affects Response To Substance	[11]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Affects Response To Substance	[11]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)	OTW3T4B2	IRPL1_HUMAN	Affects Response To Substance	[11]
Transcription factor E2-alpha (TCF3)	OTW6FR32	TFE2_HUMAN	Affects Response To Substance	[11]
Tissue alpha-L-fucosidase (FUCA1)	OTW71IK4	FUCO_HUMAN	Affects Response To Substance	[11]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Affects Response To Substance	[11]
U2 small nuclear ribonucleoprotein A' (SNRPA1)	OTWJZFAP	RU2A_HUMAN	Affects Response To Substance	[11]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Response To Substance	[12]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Response To Substance	[12]
Methyl-CpG-binding domain protein 4 (MBD4)	OTWR9YXE	MBD4_HUMAN	Affects Response To Substance	[11]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Response To Substance	[12]
GDP-mannose 4,6 dehydratase (GMDS)	OTWV79YD	GMDS_HUMAN	Affects Response To Substance	[11]
ORC ubiquitin ligase 1 (OBI1)	OTX62ZHW	OBI1_HUMAN	Affects Response To Substance	[11]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Affects Response To Substance	[11]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Affects Response To Substance	[11]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Increases Response To Substance	[12]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Affects Response To Substance	[11]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Affects Response To Substance	[11]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Affects Response To Substance	[11]
Nucleolar complex protein 3 homolog (NOC3L)	OTYOR3PV	NOC3L_HUMAN	Affects Response To Substance	[11]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Affects Response To Substance	[11]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Affects Response To Substance	[11]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Affects Response To Substance	[11]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Affects Response To Substance	[11]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Affects Response To Substance	[11]
Suppressor of tumorigenicity 7 protein (ST7)	OTZG8RC6	ST7_HUMAN	Affects Response To Substance	[11]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Affects Response To Substance	[11]
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⏷ Show the Full List of 246 DOT(s)

Indication(s) of Dasatinib

Disease Entry	ICD 11	Status	REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive	N.A.	Approved	[6]
Brain disease	8C70-8E61	Approved	[6]
Central nervous system disease	8A04-8D87	Approved	[6]
Chronic myelogenous leukaemia	2A20.0	Approved	[7]
Chronic myeloid leukaemia	2A20	Approved	[8]
Glioblastoma	2A00	Approved	[6]
Leukemia	N.A.	Approved	[6]
Lung cancer	2C25.0	Approved	[6]
Non-small-cell lung cancer	2C25.Y	Approved	[6]
Plasma cell myeloma	2A83.1	Approved	[6]
Multiple myeloma	2A83	Phase 2	[7]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[9]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[9]

Dasatinib Interacts with 5 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[34]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[34]
Fusion protein Bcr-Abl (Bcr-Abl)	TTS7G69	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[34]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[34]
HUMAN fusion protein Bcr-Abl (Bcr-Abl)	TTE63HY	BCR_HUMAN/ABL1_HUMAN	Inhibitor	[9]
------------------------------------------------------------------------------------

Dasatinib Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[35]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[36]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[37]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[37]
------------------------------------------------------------------------------------

Dasatinib Interacts with 4 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[38]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[38]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[38]
Dimethylaniline oxidase 3 (FMO3)	DEP76YL	FMO3_HUMAN	Metabolism	[39]
------------------------------------------------------------------------------------

Dasatinib Interacts with 453 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Binding	[31]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)	OTB6YLFT	ENPP3_HUMAN	Decreases Expression	[31]
Tyrosine-protein kinase HCK (HCK)	OTRL6OSI	HCK_HUMAN	Decreases Phosphorylation	[31]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Decreases Expression	[31]
Tyrosine-protein kinase Fgr (FGR)	OTCUYU9F	FGR_HUMAN	Affects Binding	[31]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Affects Binding	[31]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Decreases Expression	[31]
Tyrosine-protein kinase CSK (CSK)	OTP03OD0	CSK_HUMAN	Affects Binding	[31]
Tyrosine-protein kinase Tec (TEC)	OTU6QJAJ	TEC_HUMAN	Affects Binding	[31]
Tyrosine-protein kinase FRK (FRK)	OTEKV1SC	FRK_HUMAN	Affects Binding	[31]
Ephrin type-A receptor 5 (EPHA5)	OTAM0CVX	EPHA5_HUMAN	Affects Binding	[31]
Ephrin type-B receptor 4 (EPHB4)	OTKLPVXJ	EPHB4_HUMAN	Affects Binding	[31]
Sialomucin core protein 24 (CD164)	OTZ7FIU8	MUC24_HUMAN	Decreases Expression	[31]
Amidophosphoribosyltransferase (PPAT)	OTXK12ZB	PUR1_HUMAN	Affects Binding	[31]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Affects Binding	[31]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)	OT0ALMEG	M3K20_HUMAN	Affects Binding	[31]
ATP-dependent RNA helicase DDX39A (DDX39A)	OT0Z6E1K	DX39A_HUMAN	Decreases Expression	[32]
Cell division cycle 7-related protein kinase (CDC7)	OT5133XY	CDC7_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase PLK4 (PLK4)	OTV8KZDZ	PLK4_HUMAN	Decreases Expression	[32]
Nuclear envelope integral membrane protein 1 (NEMP1)	OTWN3S47	NEMP1_HUMAN	Decreases Expression	[32]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Decreases Expression	[32]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[32]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Decreases Expression	[32]
Fanconi anemia group A protein (FANCA)	OTPEFJD4	FANCA_HUMAN	Decreases Expression	[32]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[32]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Decreases Expression	[32]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[32]
Protein sprouty homolog 2 (SPRY2)	OTH0CRCZ	SPY2_HUMAN	Decreases Expression	[32]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[32]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[32]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)	OTDVVNS0	EDIL3_HUMAN	Increases Expression	[32]
NUAK family SNF1-like kinase 1 (NUAK1)	OTLLHJJQ	NUAK1_HUMAN	Increases Expression	[32]
Neuropilin-2 (NRP2)	OTZL256E	NRP2_HUMAN	Increases Expression	[32]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[32]
Tetraspanin-2 (TSPAN2)	OTTDPQF1	TSN2_HUMAN	Increases Expression	[32]
Leupaxin (LPXN)	OTUNV3CK	LPXN_HUMAN	Decreases Expression	[32]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[32]
DNA polymerase theta (POLQ)	OTBHK0E6	DPOLQ_HUMAN	Decreases Expression	[32]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Decreases Expression	[32]
Glypican-4 (GPC4)	OTUJ14DW	GPC4_HUMAN	Increases Expression	[32]
Serpin B7 (SERPINB7)	OTZ95LR2	SPB7_HUMAN	Decreases Expression	[32]
Transient receptor potential cation channel subfamily A member 1 (TRPA1)	OTRDIR5M	TRPA1_HUMAN	Decreases Expression	[32]
Ribonuclease H2 subunit A (RNASEH2A)	OT8G3G7K	RNH2A_HUMAN	Decreases Expression	[32]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[32]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[32]
Centrosomal protein of 152 kDa (CEP152)	OTOKZR9B	CE152_HUMAN	Decreases Expression	[32]
Potassium channel subfamily K member 2 (KCNK2)	OTWBT8MG	KCNK2_HUMAN	Decreases Expression	[32]
Chromosome-associated kinesin KIF4A (KIF4A)	OT3UWL7D	KIF4A_HUMAN	Decreases Expression	[32]
Structural maintenance of chromosomes protein 2 (SMC2)	OT5S0DV4	SMC2_HUMAN	Decreases Expression	[32]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Increases Expression	[32]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Increases Expression	[32]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[32]
Histone-lysine N-methyltransferase NSD2 (NSD2)	OTQ6SW4R	NSD2_HUMAN	Decreases Expression	[32]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Increases Expression	[32]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Decreases Expression	[32]
Complement C1r subcomponent (C1R)	OTA0ZNIU	C1R_HUMAN	Increases Expression	[32]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[32]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[32]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Increases Expression	[32]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Increases Expression	[32]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Increases Expression	[32]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Increases Expression	[32]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Decreases Expression	[32]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[32]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[32]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Decreases Expression	[32]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[32]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[32]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Increases Expression	[32]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[32]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Decreases Expression	[32]
Laminin subunit beta-1 (LAMB1)	OT6J9LJR	LAMB1_HUMAN	Increases Expression	[32]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[32]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Increases Expression	[32]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Increases Expression	[32]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Increases Expression	[32]
Complement C1s subcomponent (C1S)	OTCIZU2A	C1S_HUMAN	Increases Expression	[32]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[32]
Histone H2A.Z (H2AZ1)	OT3KJJNQ	H2AZ_HUMAN	Decreases Expression	[32]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Decreases Expression	[32]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Decreases Expression	[32]
Histone H1.4 (H1-4)	OTQ450A3	H14_HUMAN	Decreases Expression	[32]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[32]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[32]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Decreases Expression	[32]
Collagen alpha-1(XI) chain (COL11A1)	OTB0DRMS	COBA1_HUMAN	Increases Expression	[32]
Elastin (ELN)	OTFSO7PG	ELN_HUMAN	Increases Expression	[32]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Increases Expression	[32]
Histone H1.5 (H1-5)	OTAN7RD9	H15_HUMAN	Decreases Expression	[32]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Decreases Expression	[32]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[32]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Increases Expression	[32]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	OT3MPPYX	ENPP1_HUMAN	Decreases Expression	[32]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Expression	[32]
Integrin alpha-6 (ITGA6)	OT3FA39C	ITA6_HUMAN	Decreases Expression	[32]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Decreases Expression	[32]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[32]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[32]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[32]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Decreases Expression	[32]
Cardiac phospholamban (PLN)	OTT3RRJN	PPLA_HUMAN	Increases Expression	[32]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Decreases Expression	[32]
Dipeptidyl peptidase 4 (DPP4)	OT16MVL9	DPP4_HUMAN	Increases Expression	[32]
Leiomodin-1 (LMOD1)	OTZ2MEMG	LMOD1_HUMAN	Increases Expression	[32]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[32]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[32]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[32]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Increases Expression	[32]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Increases Expression	[32]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[32]
Histone H2B type 1-B (H2BC3)	OT1BLFJO	H2B1B_HUMAN	Decreases Expression	[32]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[32]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[32]
Syndecan-2 (SDC2)	OTEEHY1D	SDC2_HUMAN	Increases Expression	[32]
Replication factor C subunit 4 (RFC4)	OTWALD2R	RFC4_HUMAN	Decreases Expression	[32]
Replication factor C subunit 2 (RFC2)	OTJ9N6BD	RFC2_HUMAN	Decreases Expression	[32]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Increases Expression	[32]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Increases Expression	[32]
Myosin-11 (MYH11)	OTVNVWY3	MYH11_HUMAN	Increases Expression	[32]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Increases Expression	[32]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[32]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Decreases Expression	[32]
Nicotinamide N-methyltransferase (NNMT)	OTFM38GU	NNMT_HUMAN	Increases Expression	[32]
Pre-B-cell leukemia transcription factor 1 (PBX1)	OTORABGO	PBX1_HUMAN	Increases Expression	[32]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Decreases Expression	[32]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[32]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Increases Expression	[32]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[32]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[32]
Condensin-2 complex subunit D3 (NCAPD3)	OTOZY2UL	CNDD3_HUMAN	Decreases Expression	[32]
Neutral amino acid transporter A (SLC1A4)	OTVODHAE	SATT_HUMAN	Increases Expression	[32]
Cell surface glycoprotein MUC18 (MCAM)	OTT8XKGE	MUC18_HUMAN	Increases Expression	[32]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[32]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[32]
Glutathione S-transferase Mu 5 (GSTM5)	OTMMBFY8	GSTM5_HUMAN	Increases Expression	[32]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[32]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[32]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Decreases Expression	[32]
DNA primase large subunit (PRIM2)	OTGT0KTF	PRI2_HUMAN	Decreases Expression	[32]
Thrombospondin-3 (THBS3)	OTDKMUBD	TSP3_HUMAN	Increases Expression	[32]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[32]
Selenoprotein P (SELENOP)	OT02B8IR	SEPP1_HUMAN	Increases Expression	[32]
Kinetochore-associated protein 1 (KNTC1)	OTI2OOFN	KNTC1_HUMAN	Decreases Expression	[32]
Ras association domain-containing protein 2 (RASSF2)	OT2JHDO4	RASF2_HUMAN	Increases Expression	[32]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Decreases Expression	[32]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[32]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Increases Expression	[32]
Calponin-1 (CNN1)	OTVPG39Z	CNN1_HUMAN	Increases Expression	[32]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[32]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Expression	[32]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[32]
Microfibril-associated glycoprotein 4 (MFAP4)	OT5W64QY	MFAP4_HUMAN	Increases Expression	[32]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Decreases Expression	[32]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B)	OTNUPLUJ	CKS1_HUMAN	Decreases Expression	[32]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[32]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Increases Expression	[32]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Increases Expression	[32]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Increases Expression	[32]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Increases Expression	[32]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Expression	[32]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[32]
Kinesin-like protein KIF23 (KIF23)	OTY850JC	KIF23_HUMAN	Decreases Expression	[32]
Histone H1.1 (H1-1)	OTSS815G	H11_HUMAN	Decreases Expression	[32]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Decreases Expression	[32]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Decreases Expression	[32]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Increases Expression	[32]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Increases Expression	[32]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[32]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Increases Expression	[32]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Increases Expression	[32]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Decreases Expression	[32]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)	OTA0UNHM	ECH1_HUMAN	Increases Expression	[32]
MAL-like protein (MALL)	OTKGZ89D	MALL_HUMAN	Decreases Expression	[32]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[32]
Centromere protein R (ITGB3BP)	OT6Q7GR3	CENPR_HUMAN	Decreases Expression	[32]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Decreases Expression	[32]
Limbic system-associated membrane protein (LSAMP)	OTYXVQX2	LSAMP_HUMAN	Increases Expression	[32]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Increases Expression	[32]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)	OT6KFNMS	CAC1C_HUMAN	Increases Expression	[32]
DNA polymerase alpha subunit B (POLA2)	OTTWQ73N	DPOA2_HUMAN	Decreases Expression	[32]
Fibroleukin (FGL2)	OT8M3H72	FGL2_HUMAN	Increases Expression	[32]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)	OTKUW1WT	PDE3A_HUMAN	Increases Expression	[32]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Decreases Expression	[32]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[32]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[32]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Decreases Expression	[32]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Decreases Expression	[32]
Transmembrane glycoprotein NMB (GPNMB)	OTB7KQKV	GPNMB_HUMAN	Increases Expression	[32]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Decreases Expression	[32]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[32]
Condensin complex subunit 1 (NCAPD2)	OT8VGE2O	CND1_HUMAN	Decreases Expression	[32]
Disks large-associated protein 5 (DLGAP5)	OTWCN39U	DLGP5_HUMAN	Decreases Expression	[32]
SCL-interrupting locus protein (STIL)	OT9799VN	STIL_HUMAN	Decreases Expression	[32]
Pachytene checkpoint protein 2 homolog (TRIP13)	OTFM3TI9	PCH2_HUMAN	Decreases Expression	[32]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[32]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Decreases Expression	[32]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Increases Expression	[32]
Neuronal regeneration-related protein (NREP)	OT2AZPKK	NREP_HUMAN	Increases Expression	[32]
Prostacyclin synthase (PTGIS)	OTT3RW6N	PTGIS_HUMAN	Increases Expression	[32]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[32]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[32]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)	OTJ8LX4N	PCKGM_HUMAN	Increases Expression	[32]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Increases Expression	[32]
Flap endonuclease GEN homolog 1 (GEN1)	OT1XFQXF	GEN_HUMAN	Decreases Expression	[32]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)	OTCH86VF	AL1L2_HUMAN	Increases Expression	[32]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Increases Expression	[32]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[32]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Increases Expression	[32]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[32]
Centromere protein W (CENPW)	OTZL05QN	CENPW_HUMAN	Decreases Expression	[32]
Shugoshin 1 (SGO1)	OTIP6IRN	SGO1_HUMAN	Decreases Expression	[32]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4)	OTU4DSDE	HERC4_HUMAN	Decreases Expression	[32]
Testis-expressed protein 30 (TEX30)	OT87WEPQ	TEX30_HUMAN	Decreases Expression	[32]
DEP domain-containing protein 1A (DEPDC1)	OT0JWE1B	DEP1A_HUMAN	Decreases Expression	[32]
Tensin-3 (TNS3)	OTPG2D8Z	TENS3_HUMAN	Increases Expression	[32]
Cell division cycle-associated protein 2 (CDCA2)	OTX8UF9J	CDCA2_HUMAN	Decreases Expression	[32]
Protein FAM72D (FAM72D)	OTCQVOXB	FA72D_HUMAN	Decreases Expression	[32]
Repulsive guidance molecule B (RGMB)	OT2DROYU	RGMB_HUMAN	Decreases Expression	[32]
STEAP family member 1B (STEAP1B)	OTZJDFWK	STEAL_HUMAN	Decreases Expression	[32]
Mis18-binding protein 1 (MIS18BP1)	OT41T0FB	M18BP_HUMAN	Decreases Expression	[32]
Mitochondrial fission regulator 2 (MTFR2)	OTLOR68D	MTFR2_HUMAN	Decreases Expression	[32]
Rho GTPase-activating protein 11A (ARHGAP11A)	OTVQCFVP	RHGBA_HUMAN	Decreases Expression	[32]
E3 ubiquitin-protein ligase RFWD3 (RFWD3)	OTDUULBQ	RFWD3_HUMAN	Decreases Expression	[32]
Podocan-like protein 1 (PODNL1)	OTL72ES9	PONL1_HUMAN	Increases Expression	[32]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[32]
Neutral cholesterol ester hydrolase 1 (NCEH1)	OTZ66CKX	NCEH1_HUMAN	Decreases Expression	[32]
Fidgetin-like protein 1 (FIGNL1)	OTKII63K	FIGL1_HUMAN	Decreases Expression	[32]
ATPase family AAA domain-containing protein 2 (ATAD2)	OT8MCRNY	ATAD2_HUMAN	Decreases Expression	[32]
Serine protease FAM111B (FAM111B)	OT9IQ9NV	F111B_HUMAN	Decreases Expression	[32]
Protein FAM180A (FAM180A)	OTKQ7XUG	F180A_HUMAN	Decreases Expression	[32]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Increases Expression	[32]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Increases Expression	[32]
ALK and LTK ligand 1 (ALKAL1)	OTZGAZ79	ALKL1_HUMAN	Increases Expression	[32]
Protein MMS22-like (MMS22L)	OTJI0HM9	MMS22_HUMAN	Decreases Expression	[32]
Centrosomal protein of 128 kDa (CEP128)	OT922YCJ	CE128_HUMAN	Decreases Expression	[32]
DNA-binding protein RFX8 (RFX8)	OT27SFGQ	RFX8_HUMAN	Decreases Expression	[32]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Decreases Expression	[32]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[32]
Treslin (TICRR)	OT2HKWOC	TICRR_HUMAN	Decreases Expression	[32]
MAM domain-containing protein 2 (MAMDC2)	OT4GICNY	MAMC2_HUMAN	Increases Expression	[32]
LisH domain-containing protein ARMC9 (ARMC9)	OT0MZER2	ARMC9_HUMAN	Increases Expression	[32]
Rho GTPase-activating protein 22 (ARHGAP22)	OTXUQEFL	RHG22_HUMAN	Decreases Expression	[32]
Podocan (PODN)	OTV3P7P5	PODN_HUMAN	Increases Expression	[32]
Schlafen family member 11 (SLFN11)	OTJWFPMY	SLN11_HUMAN	Decreases Expression	[32]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Increases Expression	[32]
Alpha-protein kinase 2 (ALPK2)	OTWZZDQ9	ALPK2_HUMAN	Increases Expression	[32]
Myopalladin (MYPN)	OTHTOFDU	MYPN_HUMAN	Decreases Expression	[32]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)	OT89V4N5	MARH3_HUMAN	Decreases Expression	[32]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3)	OT4RZV2M	IQGA3_HUMAN	Decreases Expression	[32]
Condensin-2 complex subunit G2 (NCAPG2)	OTZYENKO	CNDG2_HUMAN	Decreases Expression	[32]
GAS2-like protein 3 (GAS2L3)	OTWPVI29	GA2L3_HUMAN	Decreases Expression	[32]
Histone H2A type 2-B (H2AC21)	OTH7W2NJ	H2A2B_HUMAN	Decreases Expression	[32]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2)	OT3TK3NN	PKHH2_HUMAN	Increases Expression	[32]
Extracellular sulfatase Sulf-2 (SULF2)	OTIXMUVL	SULF2_HUMAN	Increases Expression	[32]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Increases Expression	[32]
CD302 antigen (CD302)	OTX580VU	CD302_HUMAN	Increases Expression	[32]
Spindle and kinetochore-associated protein 3 (SKA3)	OTLHEVJD	SKA3_HUMAN	Decreases Expression	[32]
DNA damage-induced apoptosis suppressor protein (DDIAS)	OTTGG2PM	DDIAS_HUMAN	Decreases Expression	[32]
Cytoskeleton-associated protein 2-like (CKAP2L)	OT4T73GG	CKP2L_HUMAN	Decreases Expression	[32]
Fanconi anemia group M protein (FANCM)	OTNJG99Z	FANCM_HUMAN	Decreases Expression	[32]
Lung adenoma susceptibility protein 2 (C18ORF54)	OT4WJKTF	LAS2_HUMAN	Decreases Expression	[32]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Decreases Expression	[32]
Retinol dehydrogenase 10 (RDH10)	OTL9FSGF	RDH10_HUMAN	Increases Expression	[32]
Centromere protein L (CENPL)	OT7P006B	CENPL_HUMAN	Decreases Expression	[32]
Rho GTPase-activating protein 18 (ARHGAP18)	OTYMJP6H	RHG18_HUMAN	Decreases Expression	[32]
T-complex protein 11-like protein 2 (TCP11L2)	OTTIZO7B	T11L2_HUMAN	Increases Expression	[32]
Aminopeptidase O (AOPEP)	OT0MMANL	AMPO_HUMAN	Increases Expression	[32]
Junction-mediating and -regulatory protein (JMY)	OTH5FFVK	JMY_HUMAN	Increases Expression	[32]
Holliday junction recognition protein (HJURP)	OTWMV16B	HJURP_HUMAN	Decreases Expression	[32]
SHC SH2 domain-binding protein 1 (SHCBP1)	OT3A21CM	SHCBP_HUMAN	Decreases Expression	[32]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)	OTVXEF85	MDGA1_HUMAN	Increases Expression	[32]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Increases Expression	[32]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[32]
Protein CIP2A (CIP2A)	OTVS2GXA	CIP2A_HUMAN	Decreases Expression	[32]
Sodium-dependent phosphate transporter 1 (SLC20A1)	OTC3D894	S20A1_HUMAN	Decreases Expression	[32]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[32]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2)	OTIBDGQC	BMAL2_HUMAN	Decreases Expression	[32]
Centromere protein I (CENPI)	OTWRIMZ3	CENPI_HUMAN	Decreases Expression	[32]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Increases Expression	[32]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[32]
Neogenin (NEO1)	OTGJ1997	NEO1_HUMAN	Increases Expression	[32]
Histone H2B type 1-H (H2BC9)	OTQ9XX72	H2B1H_HUMAN	Decreases Expression	[32]
F-box only protein 32 (FBXO32)	OTUE978R	FBX32_HUMAN	Increases Expression	[32]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[32]
Transcription factor E2F7 (E2F7)	OTWW358N	E2F7_HUMAN	Decreases Expression	[32]
Spindle and kinetochore-associated protein 1 (SKA1)	OTDYJ12A	SKA1_HUMAN	Decreases Expression	[32]
Mdm2-binding protein (MTBP)	OTWLCW9C	MTBP_HUMAN	Decreases Expression	[32]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Decreases Expression	[32]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase greatwall (MASTL)	OTQ7YKK5	GWL_HUMAN	Decreases Expression	[32]
Centromere protein N (CENPN)	OTRO7XPD	CENPN_HUMAN	Decreases Expression	[32]
Proline-rich protein 11 (PRR11)	OT2JJ08Z	PRR11_HUMAN	Decreases Expression	[32]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Decreases Expression	[32]
Leucine-rich repeat protein 1 (LRR1)	OTSWDXVY	LLR1_HUMAN	Decreases Expression	[32]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)	OT5TS6P7	PCMD1_HUMAN	Increases Expression	[32]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)	OTB71I02	DCBD2_HUMAN	Decreases Expression	[32]
Kinesin-like protein KIF20B (KIF20B)	OTS68AHH	KI20B_HUMAN	Decreases Expression	[32]
ATPase family AAA domain-containing protein 5 (ATAD5)	OTI8ABKF	ATAD5_HUMAN	Decreases Expression	[32]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Expression	[32]
Hyaluronan and proteoglycan link protein 3 (HAPLN3)	OTB853Z1	HPLN3_HUMAN	Increases Expression	[32]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Decreases Expression	[32]
Cell division cycle-associated protein 3 (CDCA3)	OTUI8QK3	CDCA3_HUMAN	Decreases Expression	[32]
Kinesin-like protein KIF2C (KIF2C)	OTJ8G3NP	KIF2C_HUMAN	Decreases Expression	[32]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[32]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[32]
Histone H2B type 1-M (H2BC14)	OTSDZZZY	H2B1M_HUMAN	Decreases Expression	[32]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Decreases Expression	[32]
Mitochondrial genome maintenance exonuclease 1 (MGME1)	OTC5LPXX	MGME1_HUMAN	Decreases Expression	[32]
Synaptotagmin-15 (SYT15)	OT7Q088G	SYT15_HUMAN	Increases Expression	[32]
Hephaestin (HEPH)	OTZ2F15Z	HEPH_HUMAN	Increases Expression	[32]
DNA replication complex GINS protein SLD5 (GINS4)	OTCVOO3S	SLD5_HUMAN	Decreases Expression	[32]
Centromere protein K (CENPK)	OTKPUF8K	CENPK_HUMAN	Decreases Expression	[32]
Protein PIMREG (PIMREG)	OTKC8T3E	PIMRE_HUMAN	Decreases Expression	[32]
Nucleoporin NDC1 (NDC1)	OTF2GQC1	NDC1_HUMAN	Decreases Expression	[32]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Decreases Expression	[32]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[32]
TIMELESS-interacting protein (TIPIN)	OT9PZHXV	TIPIN_HUMAN	Decreases Expression	[32]
Kinesin-like protein KIFC1 (KIFC1)	OTNQDS00	KIFC1_HUMAN	Decreases Expression	[32]
Meiotic nuclear division protein 1 homolog (MND1)	OTS87F3H	MND1_HUMAN	Decreases Expression	[32]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[32]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Decreases Expression	[32]
Transmembrane 6 superfamily member 1 (TM6SF1)	OTQR4I2N	TM6S1_HUMAN	Increases Expression	[32]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Increases Expression	[32]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Decreases Expression	[32]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Decreases Expression	[32]
Kinetochore-associated protein DSN1 homolog (DSN1)	OTHROI0H	DSN1_HUMAN	Decreases Expression	[32]
Uncharacterized protein C1orf198 (C1ORF198)	OTK3L4G7	CA198_HUMAN	Increases Expression	[32]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)	OTFTH6ZY	GAPR1_HUMAN	Increases Expression	[32]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Decreases Expression	[32]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Increases Expression	[32]
Gremlin-2 (GREM2)	OTE91EWT	GREM2_HUMAN	Increases Expression	[32]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Increases Expression	[32]
Protein ECT2 (ECT2)	OTQDUCT6	ECT2_HUMAN	Decreases Expression	[32]
Claspin (CLSPN)	OTZZXNDK	CLSPN_HUMAN	Decreases Expression	[32]
Mineralization regulator ANKH (ANKH)	OTCN25R5	ANKH_HUMAN	Increases Expression	[32]
Ribonucleoprotein PTB-binding 2 (RAVER2)	OT0MDL7K	RAVR2_HUMAN	Increases Expression	[32]
Neurexin-3-beta (NRXN3)	OTJ0I7HJ	NRX3B_HUMAN	Increases Expression	[32]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[32]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[32]
Phospholipid scramblase 4 (PLSCR4)	OT2AMYLY	PLS4_HUMAN	Increases Expression	[32]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[32]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM)	OTALLHT1	FIRRM_HUMAN	Decreases Expression	[32]
Protein diaphanous homolog 3 (DIAPH3)	OTPOT23F	DIAP3_HUMAN	Decreases Expression	[32]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[32]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[32]
Tyrosyl-DNA phosphodiesterase 1 (TDP1)	OTYINMBR	TYDP1_HUMAN	Decreases Expression	[32]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Decreases Expression	[32]
Histone chaperone ASF1B (ASF1B)	OTKXX12I	ASF1B_HUMAN	Decreases Expression	[32]
PCNA-interacting partner (PARPBP)	OTPZDGW7	PARI_HUMAN	Decreases Expression	[32]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[32]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Increases Expression	[32]
Protein Mis18-alpha (MIS18A)	OTD80K5X	MS18A_HUMAN	Decreases Expression	[32]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Decreases Expression	[32]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Decreases Expression	[32]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Increases Expression	[32]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)	OT1PAIN0	CACO1_HUMAN	Increases Expression	[32]
Homologous-pairing protein 2 homolog (PSMC3IP)	OT9UB5UO	HOP2_HUMAN	Decreases Expression	[32]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Increases Expression	[32]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	OTHLNI51	ABC3B_HUMAN	Decreases Expression	[32]
STEAP1 protein (STEAP1)	OTJMW5R9	STEA1_HUMAN	Decreases Expression	[32]
Carboxypeptidase A4 (CPA4)	OT66MP0F	CBPA4_HUMAN	Decreases Expression	[32]
DNA helicase MCM8 (MCM8)	OTC93H3S	MCM8_HUMAN	Decreases Expression	[32]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[32]
Angiopoietin-related protein 2 (ANGPTL2)	OTB6JG41	ANGL2_HUMAN	Increases Expression	[32]
Integrin alpha-11 (ITGA11)	OTBWSRA1	ITA11_HUMAN	Increases Expression	[32]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Increases Expression	[32]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[32]
Synaptopodin-2 (SYNPO2)	OTC3U0YH	SYNP2_HUMAN	Increases Expression	[32]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)	OT953SV2	ATS5_HUMAN	Increases Expression	[32]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Decreases Expression	[32]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Increases Expression	[32]
Exonuclease 1 (EXO1)	OTI87RS5	EXO1_HUMAN	Decreases Expression	[32]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Increases Expression	[32]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[32]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase 38-like (STK38L)	OTI00JVW	ST38L_HUMAN	Increases Expression	[32]
Small kinetochore-associated protein (KNSTRN)	OTYA7UXS	SKAP_HUMAN	Decreases Expression	[32]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Decreases Expression	[32]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[32]
Carboxypeptidase Q (CPQ)	OTTNZNLD	CBPQ_HUMAN	Increases Expression	[32]
Transforming acidic coiled-coil-containing protein 3 (TACC3)	OTRNEZTA	TACC3_HUMAN	Decreases Expression	[32]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)	OTMRW5U5	IRAG1_HUMAN	Increases Expression	[32]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Decreases Expression	[32]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[40]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)	OTFBFPV4	ADAS_HUMAN	Increases Expression	[41]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[41]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[41]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Decreases Phosphorylation	[41]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[41]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[41]
cAMP-regulated phosphoprotein 19 (ARPP19)	OTZS3IT6	ARP19_HUMAN	Increases Expression	[41]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Increases Expression	[42]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Localization	[43]
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Activity	[44]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[42]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Activity	[45]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[46]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[46]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Increases Expression	[42]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[46]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[47]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Expression	[46]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Decreases Expression	[48]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Decreases Activity	[33]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Decreases Phosphorylation	[49]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[46]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Expression	[50]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Activity	[48]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[46]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[51]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Decreases Phosphorylation	[52]
Integrin alpha-M (ITGAM)	OTAG6HWU	ITAM_HUMAN	Increases Expression	[42]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Activity	[44]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Decreases Expression	[46]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Activity	[48]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Decreases Expression	[46]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Decreases Expression	[46]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Phosphorylation	[53]
C-C motif chemokine 1 (CCL1)	OT23NON8	CCL1_HUMAN	Decreases Expression	[46]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[54]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[33]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[33]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Decreases Expression	[46]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[54]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Phosphorylation	[52]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Phosphorylation	[55]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Phosphorylation	[51]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[44]
Tyrosine-protein kinase ABL2 (ABL2)	OTS8F4GD	ABL2_HUMAN	Affects Binding	[56]
Crk-like protein (CRKL)	OTOYSD1R	CRKL_HUMAN	Decreases Phosphorylation	[57]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[54]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[46]
Paxillin (PXN)	OTVMMUOF	PAXI_HUMAN	Decreases Phosphorylation	[55]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Cleavage	[33]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[58]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[46]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[46]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Phosphorylation	[45]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Increases Phosphorylation	[42]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Phosphorylation	[54]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Decreases Expression	[46]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[33]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[33]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[58]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1)	OTF91GTL	FIP1_HUMAN	Decreases Phosphorylation	[53]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Phosphorylation	[59]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)	OTYRXD2T	PMYT1_HUMAN	Decreases Activity	[60]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Localization	[61]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[43]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Response To Substance	[54]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)	OTK3EJFD	NSDHL_HUMAN	Decreases Response To Substance	[62]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Decreases Response To Substance	[62]
------------------------------------------------------------------------------------


⏷ Show the Full List of 453 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Carcinoma	DCWQF21	MDAMB436	Investigative	[63]
Colon carcinoma	DCG14VB	RKO	Investigative	[63]
Adenocarcinoma	DCK1CBI	CAOV3	Investigative	[1]
Adenocarcinoma	DCGGTY9	A427	Investigative	[1]
Adenocarcinoma	DCMGSXR	A549	Investigative	[1]
Adenocarcinoma	DC665WP	DLD1	Investigative	[1]
Adenocarcinoma	DCQZ368	HT29	Investigative	[1]
Adenocarcinoma	DCZX7IT	SW-620	Investigative	[1]
Adenocarcinoma	DCTEV8J	HCC-2998	Investigative	[1]
Adult T acute lymphoblastic leukemia	DC6SF5V	MOLT-4	Investigative	[1]
Amelanotic melanoma	DCHYVVA	A2058	Investigative	[1]
Amelanotic melanoma	DC5KDIG	MDA-MB-435	Investigative	[1]
Anaplastic large cell lymphoma	DCDIODJ	SR	Investigative	[1]
Clear cell renal cell carcinoma	DCBNJZS	786-0	Investigative	[1]
Cutaneous melanoma	DCTPCTE	SK-MEL-28	Investigative	[1]
Ewing sarcoma-peripheral primitive neuroectodermal tumour	DCKBQ8Y	ES2	Investigative	[1]
Germ cell tumour	DCYZ3XQ	PA1	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCJ9IQR	OVCAR-4	Investigative	[1]
Large cell lung carcinoma	DCCR1L5	NCI-H460	Investigative	[1]
Malignant melanoma	DCNRRB4	A375	Investigative	[1]
Mesothelioma	DCY20TC	MSTO	Investigative	[1]
Ovarian endometrioid adenocarcinoma	DCUK2AM	A2780	Investigative	[1]
Prostate carcinoma	DCXPPPJ	VCAP	Investigative	[1]
------------------------------------------------------------------------------------


⏷ Show the Full List of 23 DrugCom(s)

References

1	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2	Topotecan FDA Label
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7101).
4	Plant-derived compounds in clinical trials. Drug Discov Today. 2008 Feb;13(3-4):161-71.
5	ClinicalTrials.gov (NCT00765973) Topotecan Liposomes Injection for Small Cell Lung Cancer (SCLC), Ovarian Cancer and Other Advanced Solid Tumors. U.S. National Institutes of Health.
6	Dasatinib FDA Label
7	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5678).
8	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
9	Coronaviruses - drug discovery and therapeutic options. Nat Rev Drug Discov. 2016 May;15(5):327-47.
10	Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res. 2005 Jun 1;65(11):4775-81. doi: 10.1158/0008-5472.CAN-04-3332.
11	Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
12	Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
13	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
14	Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
15	Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12.
16	Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol. 2010 Oct 10;644(1-3):41-8.
17	Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
18	Topotecan is a substrate for multidrug resistance associated protein 4. Curr Drug Metab. 2006 Jan;7(1):105-18.
19	Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters. Biochem Pharmacol. 2010 Aug 15;80(4):471-9. doi: 10.1016/j.bcp.2010.04.038. Epub 2010 May 8.
20	Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res. 1999 Dec 1;59(23):5938-46.
21	Cancer cell adaptation to chemotherapy. BMC Cancer. 2005 Jul 18;5:78.
22	The effect of Topotecan on oxidative stress in MCF-7 human breast cancer cell line. Acta Biochim Pol. 2005;52(4):897-902.
23	DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Mol Cell Biol. 2005 Jun;25(12):5040-51. doi: 10.1128/MCB.25.12.5040-5051.2005.
24	Tracking the cell cycle origins for escape from topotecan action by breast cancer cells. Br J Cancer. 2003 Apr 22;88(8):1310-7. doi: 10.1038/sj.bjc.6600889.
25	Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.
26	Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. Biochem Pharmacol. 2015 Apr 1;94(3):212-9. doi: 10.1016/j.bcp.2015.01.012. Epub 2015 Feb 7.
27	Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
28	p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
29	Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
30	Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage. J Pharmacol Exp Ther. 2010 Jan;332(1):316-25. doi: 10.1124/jpet.109.159962. Epub 2009 Oct 7.
31	The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
32	Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
33	The kinase inhibitor dasatinib induces apoptosis in chronic lymphocytic leukemia cells in vitro with preference for a subgroup of patients with unmutated IgVH genes. Blood. 2008 Aug 15;112(4):1443-52. doi: 10.1182/blood-2007-11-123984. Epub 2008 Jun 12.
34	A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
35	Comparison of ATP-binding cassette transporter interactions with the tyrosine kinase inhibitors imatinib, nilotinib, and dasatinib. Drug Metab Dispos. 2010 Aug;38(8):1371-80.
36	Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti-cancer effects and pharmacological properties. Br J Pharmacol. 2009 Oct;158(4):1153-64.
37	Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
38	Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
39	Identification of the human enzymes involved in the oxidative metabolism of dasatinib: an effective approach for determining metabolite formation kinetics. Drug Metab Dispos. 2008 Sep;36(9):1828-39.
40	A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
41	Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
42	MEK/ERK dependent activation of STAT1 mediates dasatinib-induced differentiation of acute myeloid leukemia. PLoS One. 2013 Jun 25;8(6):e66915. doi: 10.1371/journal.pone.0066915. Print 2013.
43	Co-administration of NVP-AEW541 and dasatinib induces mitochondrial-mediated apoptosis through Bax activation in malignant human glioma cell lines. Int J Oncol. 2010 Sep;37(3):633-43. doi: 10.3892/ijo_00000712.
44	Combined BCR-ABL inhibition with lentiviral-delivered shRNA and dasatinib augments induction of apoptosis in Philadelphia-positive cells. Exp Hematol. 2009 Feb;37(2):206-14. doi: 10.1016/j.exphem.2008.10.013. Epub 2008 Dec 18.
45	Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
46	Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation. Blood. 2008 Feb 1;111(3):1366-77. doi: 10.1182/blood-2007-04-084814. Epub 2007 Oct 25.
47	Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
48	IL-8 and MCP-1/CCL2 regulate proteolytic activity in triple negative inflammatory breast cancer a mechanism that might be modulated by Src and Erk1/2. Toxicol Appl Pharmacol. 2020 Aug 15;401:115092. doi: 10.1016/j.taap.2020.115092. Epub 2020 Jun 5.
49	Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer. Clin Cancer Res. 2011 Feb 1;17(3):514-24. doi: 10.1158/1078-0432.CCR-10-1617. Epub 2010 Nov 24.
50	High-mobility group box 1 protein-mediated necroptosis contributes to dasatinib-induced cardiotoxicity. Toxicol Lett. 2018 Oct 15;296:39-47. doi: 10.1016/j.toxlet.2018.08.003. Epub 2018 Aug 4.
51	Dasatinib induces autophagic cell death in human ovarian cancer. Cancer. 2010 Nov 1;116(21):4980-90. doi: 10.1002/cncr.25426.
52	Dasatinib inhibits the growth of molecularly heterogeneous myeloid leukemias. Clin Cancer Res. 2010 Feb 15;16(4):1149-58. doi: 10.1158/1078-0432.CCR-09-2416. Epub 2010 Feb 9.
53	Dasatinib inhibits the growth and survival of neoplastic human eosinophils (EOL-1) through targeting of FIP1L1-PDGFRalpha. Exp Hematol. 2008 Oct;36(10):1244-53. doi: 10.1016/j.exphem.2008.04.017. Epub 2008 Jul 10.
54	Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
55	Targeted inhibition of SRC kinase signaling attenuates pancreatic tumorigenesis. Mol Cancer Ther. 2010 Aug;9(8):2322-32. doi: 10.1158/1535-7163.MCT-09-1212. Epub 2010 Aug 3.
56	The Btk tyrosine kinase is a major target of the Bcr-Abl inhibitor dasatinib. Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13283-8. doi: 10.1073/pnas.0702654104. Epub 2007 Aug 7.
57	Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78. doi: 10.1158/1078-0432.CCR-06-0980.
58	Src inhibitor dasatinib inhibits growth of breast cancer cells by modulating EGFR signaling. Cancer Lett. 2009 Oct 8;283(2):143-51. doi: 10.1016/j.canlet.2009.03.035. Epub 2009 Apr 26.
59	Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis. J Biol Chem. 2019 May 31;294(22):8732-8744. doi: 10.1074/jbc.RA119.008360. Epub 2019 Apr 17.
60	Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem. 2018 Aug 7;26(14):4014-4024. doi: 10.1016/j.bmc.2018.06.027. Epub 2018 Jun 20.
61	A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
62	Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discov. 2013 Jan;3(1):96-111. doi: 10.1158/2159-8290.CD-12-0031. Epub 2012 Nov 2.
63	Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.