Details of the Drug Combination

General Information of Drug Combination (ID: DCEDVX5)

• Drug Combination Name: Topotecan + Irinotecan
• Indication: Relapsed Small Cell Lung Cancer; Status: Phase 3 [1]
• Component Drugs:
  Topotecan (DMP6G8T): Small molecular drug
  Irinotecan (DMP6SC2): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Topotecan

Disease Entry	ICD 11	Status	REF
Central nervous system neoplasm	N.A.	Approved	[2]
Cervical cancer	2C77.0	Approved	[2]
Epithelial ovarian cancer	2B5D	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
Ovarian cancer	2C73	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Approved	[4]
Small-cell lung cancer	2C25.Y	Phase 1	[5]
Neuroblastoma	2D11.2	Investigative	[2]

Topotecan Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[11]

Topotecan Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[12]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[13]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[14]
Multidrug and toxin extrusion protein 1 (SLC47A1)	DTZGT0P	S47A1_HUMAN	Substrate	[15]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[16]
Multidrug and toxin extrusion protein 2 (SLC47A2)	DT3TX4H	S47A2_HUMAN	Substrate	[15]

Topotecan Interacts with 246 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[17]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Response To Substance	[18]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[19]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Increases Expression	[20]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[21]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[22]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Phosphorylation	[23]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[24]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[25]
Proliferating cell nuclear antigen (PCNA)	OTHZ1RIA	PCNA_HUMAN	Decreases Expression	[21]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[26]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[26]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[27]
G1/S-specific cyclin-E1 (CCNE1)	OTLD7UID	CCNE1_HUMAN	Decreases Expression	[21]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[25]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Cleavage	[17]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[24]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[28]
Caspase-2 (CASP2)	OTUDYSPP	CASP2_HUMAN	Increases Cleavage	[28]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[26]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[17]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Decreases Expression	[8]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Increases Expression	[17]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Decreases Expression	[26]
Bcl-2-like protein 12 (BCL2L12)	OTS6IFZY	B2L12_HUMAN	Decreases Expression	[25]
Three-prime repair exonuclease 1 (TREX1)	OTQG7K12	TREX1_HUMAN	Increases Expression	[23]
Histone H2A.V (H2AZ2)	OT0I5H2P	H2AV_HUMAN	Affects Response To Substance	[9]
Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)	OT0KMIYQ	RIPK2_HUMAN	Affects Response To Substance	[9]
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial (BCKDHA)	OT0LHOZB	ODBA_HUMAN	Affects Response To Substance	[9]
Secreted frizzled-related protein 1 (SFRP1)	OT0U9G41	SFRP1_HUMAN	Affects Response To Substance	[9]
Tripartite motif-containing protein 2 (TRIM2)	OT0V1YVC	TRIM2_HUMAN	Affects Response To Substance	[9]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Affects Response To Substance	[9]
Tetraspanin-8 (TSPAN8)	OT1F68WQ	TSN8_HUMAN	Affects Response To Substance	[9]
Tumor necrosis factor alpha-induced protein 8 (TNFAIP8)	OT1G9297	TFIP8_HUMAN	Affects Response To Substance	[9]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Affects Response To Substance	[9]
ATP-binding cassette sub-family D member 3 (ABCD3)	OT2PITLX	ABCD3_HUMAN	Affects Response To Substance	[9]
Optineurin (OPTN)	OT2UXWH9	OPTN_HUMAN	Affects Response To Substance	[9]
Epidermal growth factor-like protein 6 (EGFL6)	OT331X59	EGFL6_HUMAN	Decreases Response To Substance	[10]
Protein FAM171A1 (FAM171A1)	OT33BHEP	F1711_HUMAN	Affects Response To Substance	[9]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Affects Response To Substance	[9]
Cleavage stimulation factor subunit 2 tau variant (CSTF2T)	OT3IKRL2	CSTFT_HUMAN	Affects Response To Substance	[9]
Fatty acid CoA ligase Acsl3 (ACSL3)	OT3MWER1	ACSL3_HUMAN	Affects Response To Substance	[9]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Affects Response To Substance	[9]
Platelet-derived growth factor C (PDGFC)	OT3ZJ0XU	PDGFC_HUMAN	Affects Response To Substance	[9]
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4)	OT403QC1	PIN4_HUMAN	Affects Response To Substance	[9]
C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)	OT45AHMB	JIP4_HUMAN	Affects Response To Substance	[9]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Affects Response To Substance	[9]
Sorcin (SRI)	OT4R3EAC	SORCN_HUMAN	Affects Response To Substance	[9]
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)	OT4RF9Z4	PDE8A_HUMAN	Affects Response To Substance	[9]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Affects Response To Substance	[9]
Polyphosphoinositide phosphatase (FIG4)	OT501PY9	FIG4_HUMAN	Affects Response To Substance	[9]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Affects Response To Substance	[9]
RAC-gamma serine/threonine-protein kinase (AKT3)	OT5M2LFI	AKT3_HUMAN	Affects Response To Substance	[9]
Leukocyte elastase inhibitor (SERPINB1)	OT5RDUFO	ILEU_HUMAN	Affects Response To Substance	[9]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Response To Substance	[10]
Transcription activator BRG1 (SMARCA4)	OT68WOPQ	SMCA4_HUMAN	Affects Response To Substance	[9]
Metal cation symporter ZIP8 (SLC39A8)	OT6C6MNV	S39A8_HUMAN	Affects Response To Substance	[9]
Regulator of G-protein signaling 20 (RGS20)	OT6CGYHW	RGS20_HUMAN	Affects Response To Substance	[9]
BTB/POZ domain-containing protein KCTD3 (KCTD3)	OT6EGR42	KCTD3_HUMAN	Affects Response To Substance	[9]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Affects Response To Substance	[9]
Ferritin heavy chain (FTH1)	OT6IFS0O	FRIH_HUMAN	Affects Response To Substance	[9]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)	OT6MFOWF	TGM2_HUMAN	Affects Response To Substance	[9]
G-protein-signaling modulator 2 (GPSM2)	OT6RPMRM	GPSM2_HUMAN	Affects Response To Substance	[9]
Cytochrome b5 (CYB5A)	OT6SN4RM	CYB5_HUMAN	Affects Response To Substance	[9]
Ankycorbin (RAI14)	OT6USGBK	RAI14_HUMAN	Affects Response To Substance	[9]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Affects Response To Substance	[9]
Replication protein A 70 kDa DNA-binding subunit (RPA1)	OT76POLP	RFA1_HUMAN	Affects Response To Substance	[9]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Affects Response To Substance	[9]
Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)	OT7M67WT	GALT3_HUMAN	Affects Response To Substance	[9]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Affects Response To Substance	[9]
Forkhead box protein D1 (FOXD1)	OT80PRHS	FOXD1_HUMAN	Affects Response To Substance	[9]
Cbp/p300-interacting transactivator 2 (CITED2)	OT812TV7	CITE2_HUMAN	Affects Response To Substance	[9]
Raftlin (RFTN1)	OT8875JE	RFTN1_HUMAN	Affects Response To Substance	[9]
Mesoderm-specific transcript homolog protein (MEST)	OT8Q4U8Y	MEST_HUMAN	Affects Response To Substance	[9]
Four-jointed box protein 1 (FJX1)	OT8SVTSS	FJX1_HUMAN	Affects Response To Substance	[9]
Leptin receptor (LEPR)	OT9H7G0C	LEPR_HUMAN	Affects Response To Substance	[9]
Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)	OT9KXWE7	CAMP2_HUMAN	Affects Response To Substance	[9]
Oxidoreductase HTATIP2 (HTATIP2)	OT9MZ4QO	HTAI2_HUMAN	Affects Response To Substance	[9]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Affects Response To Substance	[9]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)	OTA2TBWS	HMGN3_HUMAN	Affects Response To Substance	[9]
Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)	OTA6ICI2	NUD4B_HUMAN	Affects Response To Substance	[9]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Affects Response To Substance	[9]
Autism susceptibility gene 2 protein (AUTS2)	OTAEXHSC	AUTS2_HUMAN	Affects Response To Substance	[9]
Grancalcin (GCA)	OTAJ7ZHG	GRAN_HUMAN	Affects Response To Substance	[9]
RNA polymerase II elongation factor ELL3 (ELL3)	OTALC1YD	ELL3_HUMAN	Affects Response To Substance	[9]
Receptor-type tyrosine-protein phosphatase kappa (PTPRK)	OTAP5AT3	PTPRK_HUMAN	Affects Response To Substance	[9]
snRNA-activating protein complex subunit 1 (SNAPC1)	OTAPN1NI	SNPC1_HUMAN	Affects Response To Substance	[9]
Cyclin-dependent kinase inhibitor 1C (CDKN1C)	OTASTJ3Q	CDN1C_HUMAN	Affects Response To Substance	[9]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Affects Response To Substance	[9]
Desmoplakin (DSP)	OTB2MOP8	DESP_HUMAN	Affects Response To Substance	[9]
Protein lin-7 homolog C (LIN7C)	OTB3015O	LIN7C_HUMAN	Affects Response To Substance	[9]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL)	OTB3BFCV	HNRDL_HUMAN	Affects Response To Substance	[9]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Affects Response To Substance	[9]
Microtubule-associated tumor suppressor 1 (MTUS1)	OTBPALMU	MTUS1_HUMAN	Affects Response To Substance	[9]
Cilium assembly protein DZIP1 (DZIP1)	OTBVPO66	DZIP1_HUMAN	Affects Response To Substance	[9]
Thiamin pyrophosphokinase 1 (TPK1)	OTCHPUD0	TPK1_HUMAN	Affects Response To Substance	[9]
Cytoskeleton-associated protein 2 (CKAP2)	OTCLTC0J	CKAP2_HUMAN	Affects Response To Substance	[9]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Affects Response To Substance	[9]
Cytochrome c oxidase copper chaperone (COX17)	OTCP4LH2	COX17_HUMAN	Affects Response To Substance	[9]
Tetraspanin-13 (TSPAN13)	OTCS9BZY	TSN13_HUMAN	Affects Response To Substance	[9]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Affects Response To Substance	[9]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Affects Response To Substance	[9]
Keratin, type I cytoskeletal 19 (KRT19)	OTDGDQ75	K1C19_HUMAN	Affects Response To Substance	[9]
Integrin alpha-1 (ITGA1)	OTDITIST	ITA1_HUMAN	Increases Response To Substance	[10]
AP-5 complex subunit mu-1 (AP5M1)	OTDLWEBL	AP5M1_HUMAN	Affects Response To Substance	[9]
Protein eva-1 homolog B (EVA1B)	OTDNAKQD	EVA1B_HUMAN	Affects Response To Substance	[9]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Affects Response To Substance	[9]
Dickkopf-related protein 3 (DKK3)	OTDU94EY	DKK3_HUMAN	Affects Response To Substance	[9]
Ras-related protein Rab-7L1 (RAB29)	OTDZT6LP	RAB7L_HUMAN	Affects Response To Substance	[9]
Short transient receptor potential channel 1 (TRPC1)	OTEEAGLH	TRPC1_HUMAN	Affects Response To Substance	[9]
H(+)/Cl(-) exchange transporter 3 (CLCN3)	OTEEXNMU	CLCN3_HUMAN	Affects Response To Substance	[9]
Secernin-1 (SCRN1)	OTELM5C2	SCRN1_HUMAN	Affects Response To Substance	[9]
NGFI-A-binding protein 1 (NAB1)	OTEWHIZR	NAB1_HUMAN	Affects Response To Substance	[9]
Serglycin (SRGN)	OTFAVSX0	SRGN_HUMAN	Affects Response To Substance	[9]
Solute carrier family 35 member G2 (SLC35G2)	OTFBVS0P	S35G2_HUMAN	Affects Response To Substance	[9]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Affects Response To Substance	[9]
Multiple C2 and transmembrane domain-containing protein 2 (MCTP2)	OTFMZ8I2	MCTP2_HUMAN	Affects Response To Substance	[9]
Caveolae-associated protein 1 (CAVIN1)	OTFO915U	CAVN1_HUMAN	Affects Response To Substance	[9]
Laminin subunit alpha-2 (LAMA2)	OTFROQWE	LAMA2_HUMAN	Increases Response To Substance	[10]
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1 (CSTPP1)	OTFSO3XV	CSTP1_HUMAN	Affects Response To Substance	[9]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Affects Response To Substance	[9]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Affects Response To Substance	[9]
Transmembrane protein 80 (TMEM80)	OTG9D4KX	TMM80_HUMAN	Affects Response To Substance	[9]
Squalene synthase (FDFT1)	OTGDISIT	FDFT_HUMAN	Affects Response To Substance	[9]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Affects Response To Substance	[9]
Cytotoxic granule associated RNA binding protein TIA1 (TIA1)	OTGPN3P8	TIA1_HUMAN	Affects Response To Substance	[9]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Affects Response To Substance	[9]
Sigma intracellular receptor 2 (TMEM97)	OTH76ZWK	SGMR2_HUMAN	Affects Response To Substance	[9]
Epithelial cell adhesion molecule (EPCAM)	OTHBZK5X	EPCAM_HUMAN	Affects Response To Substance	[9]
Delta-aminolevulinic acid dehydratase (ALAD)	OTHM9GSH	HEM2_HUMAN	Affects Response To Substance	[9]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Response To Substance	[9]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Affects Response To Substance	[9]
Solute carrier family 38 member 6 (SLC38A6)	OTIC8SHQ	S38A6_HUMAN	Affects Response To Substance	[9]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Affects Response To Substance	[9]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Affects Response To Substance	[9]
Laminin subunit gamma-1 (LAMC1)	OTIG527N	LAMC1_HUMAN	Affects Response To Substance	[9]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Affects Response To Substance	[9]
Beta/gamma crystallin domain-containing protein 1 (CRYBG1)	OTIPDI15	CRBG1_HUMAN	Affects Response To Substance	[9]
Ras-related protein Rab-13 (RAB13)	OTIQ484I	RAB13_HUMAN	Affects Response To Substance	[9]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Response To Substance	[9]
Ankyrin repeat domain-containing protein 10 (ANKRD10)	OTIZ2VK8	ANR10_HUMAN	Affects Response To Substance	[9]
Histone deacetylase complex subunit SAP18 (SAP18)	OTJAZWOL	SAP18_HUMAN	Affects Response To Substance	[9]
E3 ubiquitin-protein ligase FANCL (FANCL)	OTJC7QPQ	FANCL_HUMAN	Affects Response To Substance	[9]
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)	OTJDOL20	HCDH_HUMAN	Affects Response To Substance	[9]
FERM domain-containing protein 4A (FRMD4A)	OTJDTIK2	FRM4A_HUMAN	Affects Response To Substance	[9]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Affects Response To Substance	[9]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Affects Response To Substance	[9]
Jupiter microtubule associated homolog 2 (JPT2)	OTJGPA4T	JUPI2_HUMAN	Affects Response To Substance	[9]
TBC1 domain family member 4 (TBC1D4)	OTK66C40	TBCD4_HUMAN	Affects Response To Substance	[9]
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B)	OTKAN9G7	TNF6B_HUMAN	Affects Response To Substance	[9]
Myelin protein zero-like protein 2 (MPZL2)	OTKFNDUI	MPZL2_HUMAN	Affects Response To Substance	[9]
Transmembrane channel-like protein 6 (TMC6)	OTKH50J4	TMC6_HUMAN	Affects Response To Substance	[9]
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2)	OTKOZRZP	PLOD2_HUMAN	Affects Response To Substance	[9]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Affects Response To Substance	[9]
Enolase-phosphatase E1 (ENOPH1)	OTKXMWNN	ENOPH_HUMAN	Affects Response To Substance	[9]
Calcium-binding tyrosine phosphorylation-regulated protein (CABYR)	OTKYMT99	CABYR_HUMAN	Affects Response To Substance	[9]
Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)	OTLNA39Z	NMT2_HUMAN	Affects Response To Substance	[9]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Response To Substance	[10]
Ribosome biogenesis protein BOP1 (BOP1)	OTMZMQDO	BOP1_HUMAN	Affects Response To Substance	[9]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (GSPT2)	OTN0K7F3	ERF3B_HUMAN	Affects Response To Substance	[9]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Affects Response To Substance	[9]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Affects Response To Substance	[9]
Epithelial splicing regulatory protein 1 (ESRP1)	OTNCS4SL	ESRP1_HUMAN	Affects Response To Substance	[9]
Radixin (RDX)	OTNSYUN6	RADI_HUMAN	Affects Response To Substance	[9]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1)	OTNYXOZO	KCMA1_HUMAN	Affects Response To Substance	[9]
Paraneoplastic antigen-like protein 8A (PNMA8A)	OTO3F7B0	PNM8A_HUMAN	Affects Response To Substance	[9]
Polypeptide N-acetylgalactosaminyltransferase 1 (GALNT1)	OTO3RO36	GALT1_HUMAN	Affects Response To Substance	[9]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Affects Response To Substance	[9]
Histone-lysine N-methyltransferase KMT5B (KMT5B)	OTOH7G8Q	KMT5B_HUMAN	Affects Response To Substance	[9]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Affects Response To Substance	[9]
GTP cyclohydrolase 1 (GCH1)	OTOZ6NSL	GCH1_HUMAN	Affects Response To Substance	[9]
Unconventional myosin-Id (MYO1D)	OTP2RGPN	MYO1D_HUMAN	Affects Response To Substance	[9]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Affects Response To Substance	[9]
Ras-related protein Rab-20 (RAB20)	OTP9OOVS	RAB20_HUMAN	Affects Response To Substance	[9]
Dual specificity protein phosphatase 3 (DUSP3)	OTPJX9B4	DUS3_HUMAN	Affects Response To Substance	[9]
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)	OTPL0AI1	ABC3C_HUMAN	Affects Response To Substance	[9]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Affects Response To Substance	[9]
Dermatan-sulfate epimerase (DSE)	OTQ108VJ	DSE_HUMAN	Affects Response To Substance	[9]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Affects Response To Substance	[9]
Eukaryotic translation initiation factor 5A-1 (EIF5A)	OTQ8DJX5	IF5A1_HUMAN	Affects Response To Substance	[9]
Sortilin-related receptor (SORL1)	OTQ8FFNS	SORL_HUMAN	Affects Response To Substance	[9]
Collagen alpha-2(VI) chain (COL6A2)	OTQC6PPO	CO6A2_HUMAN	Affects Response To Substance	[9]
Ran-specific GTPase-activating protein (RANBP1)	OTQE226K	RANG_HUMAN	Affects Response To Substance	[9]
MAPK/MAK/MRK overlapping kinase (MOK)	OTQK7M9V	MOK_HUMAN	Affects Response To Substance	[9]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Affects Response To Substance	[9]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Affects Response To Substance	[9]
Keratin, type I cytoskeletal 23 (KRT23)	OTQW6UAG	K1C23_HUMAN	Increases Response To Substance	[10]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Response To Substance	[10]
Large ribosomal subunit protein mL63 (MRPL57)	OTRB659E	RT63_HUMAN	Affects Response To Substance	[9]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Affects Response To Substance	[9]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)	OTRHPFO2	AN32A_HUMAN	Affects Response To Substance	[9]
LIM domain kinase 2 (LIMK2)	OTRJD7VZ	LIMK2_HUMAN	Affects Response To Substance	[9]
Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)	OTRN55RE	KCC1A_HUMAN	Affects Response To Substance	[9]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Affects Response To Substance	[9]
Lysyl oxidase homolog 2 (LOXL2)	OTRT46B5	LOXL2_HUMAN	Affects Response To Substance	[9]
Arginine and glutamate-rich protein 1 (ARGLU1)	OTRVRZ4Z	ARGL1_HUMAN	Affects Response To Substance	[9]
Dr1-associated corepressor (DRAP1)	OTRWLF6D	NC2A_HUMAN	Affects Response To Substance	[9]
Latent-transforming growth factor beta-binding protein 2 (LTBP2)	OTS88GSD	LTBP2_HUMAN	Affects Response To Substance	[9]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Affects Response To Substance	[9]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Affects Response To Substance	[9]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Decreases Response To Substance	[10]
GTP-binding protein SAR1a (SAR1A)	OTSSRVGV	SAR1A_HUMAN	Affects Response To Substance	[9]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Affects Response To Substance	[9]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Decreases Response To Substance	[10]
DNA-binding protein SATB1 (SATB1)	OTT7SUVW	SATB1_HUMAN	Affects Response To Substance	[9]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Affects Response To Substance	[9]
KH domain-containing RNA-binding protein QKI (QKI)	OTTAUGLB	QKI_HUMAN	Affects Response To Substance	[9]
Cullin-4A (CUL4A)	OTTBV70J	CUL4A_HUMAN	Affects Response To Substance	[9]
Homeobox protein Hox-B2 (HOXB2)	OTTD6HMV	HXB2_HUMAN	Affects Response To Substance	[9]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Decreases Response To Substance	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Affects Response To Substance	[9]
Nuclear receptor-interacting protein 3 (NRIP3)	OTU15GMK	NRIP3_HUMAN	Affects Response To Substance	[9]
Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (CSF2RA)	OTUOO2XS	CSF2R_HUMAN	Affects Response To Substance	[9]
La-related protein 6 (LARP6)	OTUQ9QS9	LARP6_HUMAN	Affects Response To Substance	[9]
General transcription factor II-I (GTF2I)	OTUYL1TQ	GTF2I_HUMAN	Affects Response To Substance	[9]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Affects Response To Substance	[9]
FYVE, RhoGEF and PH domain-containing protein 1 (FGD1)	OTV3T64P	FGD1_HUMAN	Affects Response To Substance	[9]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Decreases Response To Substance	[10]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)	OTVIHD77	MACF1_HUMAN	Affects Response To Substance	[9]
Serine protease FAM111A (FAM111A)	OTVLARLG	F111A_HUMAN	Affects Response To Substance	[9]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Affects Response To Substance	[9]
Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)	OTW3T4B2	IRPL1_HUMAN	Affects Response To Substance	[9]
Transcription factor E2-alpha (TCF3)	OTW6FR32	TFE2_HUMAN	Affects Response To Substance	[9]
Tissue alpha-L-fucosidase (FUCA1)	OTW71IK4	FUCO_HUMAN	Affects Response To Substance	[9]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Affects Response To Substance	[9]
U2 small nuclear ribonucleoprotein A' (SNRPA1)	OTWJZFAP	RU2A_HUMAN	Affects Response To Substance	[9]
Decorin (DCN)	OTWLJL7K	PGS2_HUMAN	Decreases Response To Substance	[10]
Periostin (POSTN)	OTWP62UA	POSTN_HUMAN	Decreases Response To Substance	[10]
Methyl-CpG-binding domain protein 4 (MBD4)	OTWR9YXE	MBD4_HUMAN	Affects Response To Substance	[9]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Response To Substance	[10]
GDP-mannose 4,6 dehydratase (GMDS)	OTWV79YD	GMDS_HUMAN	Affects Response To Substance	[9]
ORC ubiquitin ligase 1 (OBI1)	OTX62ZHW	OBI1_HUMAN	Affects Response To Substance	[9]
Caspase-6 (CASP6)	OTXLD3EC	CASP6_HUMAN	Affects Response To Substance	[9]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Affects Response To Substance	[9]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Increases Response To Substance	[10]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Affects Response To Substance	[9]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Affects Response To Substance	[9]
Protein Niban 1 (NIBAN1)	OTYOLI12	NIBA1_HUMAN	Affects Response To Substance	[9]
Nucleolar complex protein 3 homolog (NOC3L)	OTYOR3PV	NOC3L_HUMAN	Affects Response To Substance	[9]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Affects Response To Substance	[9]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Affects Response To Substance	[9]
Thiosulfate sulfurtransferase (TST)	OTZ4F5LK	THTR_HUMAN	Affects Response To Substance	[9]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Affects Response To Substance	[9]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Affects Response To Substance	[9]
Suppressor of tumorigenicity 7 protein (ST7)	OTZG8RC6	ST7_HUMAN	Affects Response To Substance	[9]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Affects Response To Substance	[9]

Indication(s) of Irinotecan

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[6]
Advanced cancer	2A00-2F9Z	Approved	[6]
Appendiceal neoplasm	N.A.	Approved	[6]
Astrocytoma	2A00.0Y	Approved	[6]
Brain glioma	N.A.	Approved	[6]
Colon adenocarcinoma	N.A.	Approved	[6]
Colorectal cancer	2B91.Z	Approved	[7]
Endocrine gland neoplasm	N.A.	Approved	[6]
Kidney neoplasm	N.A.	Approved	[6]
Metastasis from malignant tumor of colon	N.A.	Approved	[6]
Peritoneal neoplasm	N.A.	Approved	[6]
Rectal adenocarcinoma	2B92	Approved	[6]
Rectal neoplasm	N.A.	Approved	[6]
Rectum mucinous adenocarcinoma	N.A.	Approved	[6]
Adult glioblastoma	N.A.	Investigative	[6]
Colon cancer	2B90.Z	Investigative	[6]
Colon mucinous adenocarcinoma	N.A.	Investigative	[6]
Diarrhea	ME05.1	Investigative	[6]
Gastric cancer	2B72	Investigative	[6]
Neuroblastoma	2D11.2	Investigative	[6]

Irinotecan Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[11]

Irinotecan Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[37]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[38]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[38]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[39]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[40]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[41]

Irinotecan Interacts with 8 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[42]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[43]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[44]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[45]
Carboxylesterase 1 (CES1)	DEB30C5	EST1_HUMAN	Metabolism	[42]
Carboxylesterase 3 (CES3)	DEMI4VE	EST3_HUMAN	Metabolism	[46]
Carboxylesterase 2 (CES2)	DETHCPD	EST2_HUMAN	Metabolism	[46]
Beta-glucuronidase (uidA)	DE9RA0I	BGLR_ECOLI	Metabolism	[47]

Irinotecan Interacts with 469 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Expression	[48]
Carboxylesterase 3 (CES3)	OT00OP43	EST3_HUMAN	Increases Hydrolysis	[46]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Response To Substance	[49]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Response To Substance	[49]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Expression	[32]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Decreases Response To Substance	[50]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Increases Response To Substance	[49]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Response To Substance	[50]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Increases ADR	[51]
Thiopurine S-methyltransferase (TPMT)	OTFOX70W	TPMT_HUMAN	Increases Expression	[32]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Decreases Activity	[52]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Activity	[52]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Increases Expression	[53]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[53]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[53]
B-cell CLL/lymphoma 9 protein (BCL9)	OTRBIPR4	BCL9_HUMAN	Increases Expression	[31]
Chromodomain-helicase-DNA-binding protein 1 (CHD1)	OT9R9G0H	CHD1_HUMAN	Decreases Expression	[31]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Increases Expression	[31]
tRNA (TRDMT1)	OTAYQ8ZF	TRDMT_HUMAN	Decreases Expression	[31]
Guanine nucleotide exchange factor DBS (MCF2L)	OTEURA8N	MCF2L_HUMAN	Decreases Expression	[31]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Increases Expression	[31]
Monocarboxylate transporter 5 (SLC16A4)	OT1YXBKC	MOT5_HUMAN	Decreases Expression	[31]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[31]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Decreases Expression	[31]
A-kinase anchor protein 10, mitochondrial (AKAP10)	OTPNFTOU	AKA10_HUMAN	Decreases Expression	[31]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[31]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[31]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[31]
Heat shock 70 kDa protein 4L (HSPA4L)	OT181WZB	HS74L_HUMAN	Decreases Expression	[31]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[31]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[31]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[31]
Lactotransferrin (LTF)	OT8JWCZ0	TRFL_HUMAN	Decreases Expression	[31]
Histidine-rich glycoprotein (HRG)	OTPLUFOG	HRG_HUMAN	Increases Expression	[31]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Increases Expression	[31]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Increases Expression	[31]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Decreases Expression	[31]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[31]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[31]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Decreases Expression	[31]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Increases Expression	[31]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Increases Expression	[31]
Sulfotransferase 1A3 (SULT1A4)	OTHJ8WWV	ST1A3_HUMAN	Increases Expression	[31]
Serine/threonine-protein kinase A-Raf (ARAF)	OTZJ0FNO	ARAF_HUMAN	Increases Expression	[31]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[31]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Increases Expression	[31]
Keratin, type II cytoskeletal 5 (KRT5)	OTVGI9HT	K2C5_HUMAN	Decreases Expression	[31]
Nidogen-1 (NID1)	OTKLBLS6	NID1_HUMAN	Increases Expression	[31]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[31]
Protein C-ets-2 (ETS2)	OTPVHOZ7	ETS2_HUMAN	Increases Expression	[31]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[31]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)	OTEGNEHW	PP2BB_HUMAN	Decreases Expression	[31]
SH2/SH3 adapter protein NCK1 (NCK1)	OTKYZ4OP	NCK1_HUMAN	Decreases Expression	[31]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[31]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[31]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[31]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Decreases Expression	[31]
Integrin alpha-X (ITGAX)	OTOGIMHE	ITAX_HUMAN	Increases Expression	[31]
Myelin and lymphocyte protein (MAL)	OTBM30SW	MAL_HUMAN	Increases Expression	[31]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[31]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)	OTJXOUCL	HEM0_HUMAN	Increases Expression	[31]
Receptor-type tyrosine-protein phosphatase delta (PTPRD)	OTZPJ3GX	PTPRD_HUMAN	Increases Expression	[31]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)	OTGP7D5Y	GATA3_HUMAN	Decreases Expression	[31]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Decreases Expression	[31]
Retinoblastoma-like protein 1 (RBL1)	OTDEBFYC	RBL1_HUMAN	Decreases Expression	[31]
AT-rich interactive domain-containing protein 4A (ARID4A)	OT1XKBZ0	ARI4A_HUMAN	Decreases Expression	[31]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[31]
Syndecan-4 (SDC4)	OTKUVUGZ	SDC4_HUMAN	Increases Expression	[31]
C-C chemokine receptor type 1 (CCR1)	OT4FC783	CCR1_HUMAN	Increases Expression	[31]
G-protein coupled receptor 183 (GPR183)	OTRILX7G	GP183_HUMAN	Increases Expression	[31]
CD70 antigen (CD70)	OTHB2AL1	CD70_HUMAN	Increases Expression	[31]
T-lymphocyte activation antigen CD80 (CD80)	OTJBLUQE	CD80_HUMAN	Increases Expression	[31]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[31]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Decreases Expression	[31]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[31]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Decreases Expression	[31]
Transcription factor ETV6 (ETV6)	OTCZMG61	ETV6_HUMAN	Decreases Expression	[31]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[31]
Hydroxycarboxylic acid receptor 3 (HCAR3)	OTJBHLX0	HCAR3_HUMAN	Increases Expression	[31]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[31]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Decreases Expression	[31]
5-formyltetrahydrofolate cyclo-ligase (MTHFS)	OTZ39JNR	MTHFS_HUMAN	Decreases Expression	[31]
Protein Tob1 (TOB1)	OTNW949D	TOB1_HUMAN	Increases Expression	[31]
C-C chemokine receptor type 6 (CCR6)	OT61JMYX	CCR6_HUMAN	Decreases Expression	[31]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[31]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[31]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[31]
UV excision repair protein RAD23 homolog B (RAD23B)	OT0PGOG3	RD23B_HUMAN	Decreases Expression	[31]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[31]
Neutrophil defensin 1 (DEFA1)	OT5N1B9B	DEF1_HUMAN	Decreases Expression	[31]
Ras-related C3 botulinum toxin substrate 3 (RAC3)	OT2RE7A7	RAC3_HUMAN	Increases Expression	[31]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[31]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[31]
Runt-related transcription factor 1 (RUNX1)	OTU7J84H	RUNX1_HUMAN	Decreases Expression	[31]
Transcription factor Spi-B (SPIB)	OTO4YKYI	SPIB_HUMAN	Increases Expression	[31]
Myocyte-specific enhancer factor 2B (MEF2B)	OT880SE6	MEF2B_HUMAN	Increases Expression	[31]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Decreases Expression	[31]
Dual specificity protein phosphatase 2 (DUSP2)	OTH54FMR	DUS2_HUMAN	Increases Expression	[31]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Decreases Expression	[31]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Increases Expression	[31]
Dystrophia myotonica WD repeat-containing protein (DMWD)	OT0CBZ6F	DMWD_HUMAN	Increases Expression	[31]
Histone acetyltransferase p300 (EP300)	OTL8QJDX	EP300_HUMAN	Decreases Expression	[31]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Decreases Expression	[31]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)	OTESFZSO	PTN13_HUMAN	Decreases Expression	[31]
Rho GTPase-activating protein 5 (ARHGAP5)	OTOQELUN	RHG05_HUMAN	Decreases Expression	[31]
MAL-like protein (MALL)	OTKGZ89D	MALL_HUMAN	Increases Expression	[31]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Decreases Expression	[31]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[31]
Cyclin-dependent kinase 5 activator 2 (CDK5R2)	OTNUTLPU	CD5R2_HUMAN	Increases Expression	[31]
Centromere protein R (ITGB3BP)	OT6Q7GR3	CENPR_HUMAN	Decreases Expression	[31]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)	OTPLXCDN	DYR1A_HUMAN	Decreases Expression	[31]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[31]
Krueppel-like factor 9 (KLF9)	OTBFEJRQ	KLF9_HUMAN	Increases Expression	[31]
Cyclin-dependent kinase 13 (CDK13)	OT3P7JF1	CDK13_HUMAN	Decreases Expression	[31]
Protein Tob2 (TOB2)	OTEEHL60	TOB2_HUMAN	Increases Expression	[31]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Increases Expression	[31]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Decreases Expression	[31]
Receptor tyrosine-protein kinase erbB-4 (ERBB4)	OT9L6C41	ERBB4_HUMAN	Increases Expression	[31]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)	OTRHB9SR	NHRF2_HUMAN	Increases Expression	[31]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)	OTBOSJHO	TRADD_HUMAN	Increases Expression	[31]
Nuclear receptor coactivator 1 (NCOA1)	OTLIUJQD	NCOA1_HUMAN	Increases Expression	[31]
Tubulin-specific chaperone C (TBCC)	OTBF0X8R	TBCC_HUMAN	Increases Expression	[31]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[31]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN)	OTAP7NOL	PTPRN_HUMAN	Increases Expression	[31]
B-cell CLL/lymphoma 7 protein family member A (BCL7A)	OTYFUJTP	BCL7A_HUMAN	Increases Expression	[31]
Transmembrane protein 41B (TMEM41B)	OTW0B0KS	TM41B_HUMAN	Decreases Expression	[31]
Transcription initiation factor TFIID subunit 2 (TAF2)	OTTIGJ9M	TAF2_HUMAN	Decreases Expression	[31]
DNA cross-link repair 1A protein (DCLRE1A)	OT68PVSD	DCR1A_HUMAN	Decreases Expression	[31]
C-myc promoter-binding protein (DENND4A)	OT8FFZ29	MYCPP_HUMAN	Decreases Expression	[31]
COMM domain-containing protein 6 (COMMD6)	OTRZQJFW	COMD6_HUMAN	Increases Expression	[31]
Bone morphogenetic protein 8A (BMP8A)	OT1997IN	BMP8A_HUMAN	Increases Expression	[31]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3)	OTREOQBO	PKHH3_HUMAN	Increases Expression	[31]
DNA damage-binding protein 2 (DDB2)	OTO8HVVB	DDB2_HUMAN	Increases Expression	[31]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)	OTMDVWPS	DYRK2_HUMAN	Decreases Expression	[31]
Histone H2A type 1-C (H2AC6)	OTF3YK7V	H2A1C_HUMAN	Decreases Expression	[31]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[31]
Sorting nexin-18 (SNX18)	OT68KT3X	SNX18_HUMAN	Decreases Expression	[31]
Oncostatin-M-specific receptor subunit beta (OSMR)	OTORWHPL	OSMR_HUMAN	Increases Expression	[31]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Decreases Expression	[31]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[31]
Ubiquitin-like-conjugating enzyme ATG10 (ATG10)	OTVRPC5X	ATG10_HUMAN	Decreases Expression	[31]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[31]
E3 ubiquitin-protein ligase Topors (TOPORS)	OT1ERFFQ	TOPRS_HUMAN	Decreases Expression	[31]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases Expression	[31]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Decreases Expression	[31]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[31]
Protocadherin gamma-C3 (PCDHGC3)	OTDXTUMI	PCDGK_HUMAN	Increases Expression	[31]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22)	OTDCNTC3	PTN22_HUMAN	Increases Expression	[31]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)	OTBV52DR	SMHD1_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[32]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Increases Expression	[32]
Krev interaction trapped protein 1 (KRIT1)	OT58AP1I	KRIT1_HUMAN	Decreases Expression	[32]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Decreases Expression	[32]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Increases Expression	[32]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL)	OTB3BFCV	HNRDL_HUMAN	Decreases Expression	[32]
Centrosomal protein of 290 kDa (CEP290)	OTVN52VH	CE290_HUMAN	Decreases Expression	[32]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)	OTRBREQ9	ANR28_HUMAN	Decreases Expression	[32]
FYN-binding protein 1 (FYB1)	OT6345CH	FYB1_HUMAN	Decreases Expression	[32]
Protein phosphatase 1D (PPM1D)	OT8NLZ9D	PPM1D_HUMAN	Increases Expression	[32]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Decreases Expression	[32]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[32]
Density-regulated protein (DENR)	OTXP9HOY	DENR_HUMAN	Decreases Expression	[32]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)	OTBTA03N	MARH6_HUMAN	Increases Expression	[32]
Oligophrenin-1 (OPHN1)	OTDURZAV	OPHN1_HUMAN	Increases Expression	[32]
NEDD4-binding protein 1 (N4BP1)	OTN2TL6N	N4BP1_HUMAN	Decreases Expression	[32]
Ankyrin repeat domain-containing protein 17 (ANKRD17)	OTQ3DYEP	ANR17_HUMAN	Decreases Expression	[32]
Nuclear receptor corepressor 1 (NCOR1)	OT04XNOU	NCOR1_HUMAN	Decreases Expression	[32]
Death effector domain-containing protein (DEDD)	OTIL349E	DEDD_HUMAN	Decreases Expression	[32]
Glutaredoxin-3 (GLRX3)	OTUPAU1N	GLRX3_HUMAN	Affects Expression	[32]
Tubulin polymerization-promoting protein (TPPP)	OTCFMSUF	TPPP_HUMAN	Increases Expression	[32]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Decreases Expression	[32]
SR-related and CTD-associated factor 4 (SCAF4)	OTFGHB1E	SCAF4_HUMAN	Decreases Expression	[32]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Increases Expression	[32]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Decreases Expression	[32]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Decreases Expression	[32]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Decreases Expression	[32]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Increases Expression	[32]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Decreases Expression	[32]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Increases Expression	[32]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Decreases Expression	[32]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Increases Expression	[32]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Decreases Expression	[32]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[32]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)	OTIRPN6B	ROA1_HUMAN	Decreases Expression	[32]
U2 small nuclear ribonucleoprotein A' (SNRPA1)	OTWJZFAP	RU2A_HUMAN	Decreases Expression	[32]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[32]
Chorionic somatomammotropin hormone 2 (CSH2)	OTW8JVAN	CSH2_HUMAN	Decreases Expression	[32]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Decreases Expression	[32]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Expression	[32]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Increases Expression	[32]
HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4)	OTNXIHQU	DRB4_HUMAN	Increases Expression	[32]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Decreases Expression	[32]
Arylsulfatase B (ARSB)	OTTYDDNU	ARSB_HUMAN	Decreases Expression	[32]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[32]
Integrin alpha-2 (ITGA2)	OTPFL017	ITA2_HUMAN	Increases Expression	[32]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Affects Expression	[32]
Peptidyl-glycine alpha-amidating monooxygenase (PAM)	OTX8HV5B	AMD_HUMAN	Decreases Expression	[32]
Glutathione hydrolase 1 proenzyme (GGT1)	OTYDA1Z7	GGT1_HUMAN	Decreases Expression	[32]
Ras GTPase-activating protein 1 (RASA1)	OTZJ3LP4	RASA1_HUMAN	Decreases Expression	[32]
Synaptotagmin-1 (SYT1)	OTVTPOI6	SYT1_HUMAN	Decreases Expression	[32]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Decreases Expression	[32]
Paired box protein Pax-7 (PAX7)	OTDMQRPO	PAX7_HUMAN	Decreases Expression	[32]
Annexin A13 (ANXA13)	OTM33P73	ANX13_HUMAN	Decreases Expression	[32]
Lens fiber major intrinsic protein (MIP)	OTEBLU3E	MIP_HUMAN	Decreases Expression	[32]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Decreases Expression	[32]
Glycerol kinase (GK)	OTK2YRA0	GLPK_HUMAN	Decreases Expression	[32]
Cystathionine gamma-lyase (CTH)	OTC90LA0	CGL_HUMAN	Increases Expression	[32]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Decreases Expression	[32]
Large ribosomal subunit protein uL4 (RPL4)	OTTYJB0X	RL4_HUMAN	Decreases Expression	[32]
T-complex protein 1 subunit zeta (CCT6A)	OTCYWL5F	TCPZ_HUMAN	Decreases Expression	[32]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Decreases Expression	[32]
Matrin-3 (MATR3)	OTESJ5S7	MATR3_HUMAN	Decreases Expression	[32]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Decreases Expression	[32]
Vesicle-fusing ATPase (NSF)	OTKRJ2ZT	NSF_HUMAN	Decreases Expression	[32]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[32]
Nuclear pore complex protein Nup153 (NUP153)	OTCAS0AR	NU153_HUMAN	Decreases Expression	[32]
Gastrotropin (FABP6)	OTIRQWLW	FABP6_HUMAN	Increases Expression	[32]
Host cell factor 1 (HCFC1)	OT0UCK62	HCFC1_HUMAN	Decreases Expression	[32]
Collagen alpha-4(IV) chain (COL4A4)	OT9G0MCT	CO4A4_HUMAN	Decreases Expression	[32]
Coatomer subunit alpha (COPA)	OTZ1DTXU	COPA_HUMAN	Increases Expression	[32]
Cadherin-4 (CDH4)	OT8LH3HN	CADH4_HUMAN	Decreases Expression	[32]
C-terminal-binding protein 2 (CTBP2)	OTGZGT87	CTBP2_HUMAN	Decreases Expression	[32]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Increases Expression	[32]
Epiplakin (EPPK1)	OT7BAU8C	EPIPL_HUMAN	Increases Expression	[32]
Lysyl oxidase homolog 3 (LOXL3)	OTLLY1QI	LOXL3_HUMAN	Decreases Expression	[32]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[32]
AP-2 complex subunit beta (AP2B1)	OTL6LZJ4	AP2B1_HUMAN	Decreases Expression	[32]
Hemoglobin subunit gamma-1 (HBG1)	OTVL4NSU	HBG1_HUMAN	Decreases Expression	[32]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Expression	[32]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Decreases Expression	[32]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Affects Expression	[32]
Clathrin heavy chain 1 (CLTC)	OTBFASMA	CLH1_HUMAN	Decreases Expression	[32]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[32]
Paired box protein Pax-5 (PAX5)	OTYBJJWX	PAX5_HUMAN	Decreases Expression	[32]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Decreases Expression	[32]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Expression	[32]
Recombining binding protein suppressor of hairless (RBPJ)	OTD7CUG0	SUH_HUMAN	Decreases Expression	[32]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)	OT5GO2PL	KHDR1_HUMAN	Decreases Expression	[32]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA)	OT58PUEN	PP2BA_HUMAN	Decreases Expression	[32]
Leukocyte surface antigen CD47 (CD47)	OTLDZ0KZ	CD47_HUMAN	Increases Expression	[32]
Transmembrane protein 267 (TMEM267)	OTEAAVK7	TM267_HUMAN	Decreases Expression	[32]
Proline-rich nuclear receptor coactivator 1 (PNRC1)	OTQMLEE1	PNRC1_HUMAN	Increases Expression	[32]
Alpha-globin transcription factor CP2 (TFCP2)	OTA246TE	TFCP2_HUMAN	Decreases Expression	[32]
Disks large homolog 1 (DLG1)	OTCRZYWT	DLG1_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase 4 (STK4)	OTBRYNNH	STK4_HUMAN	Decreases Expression	[32]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Decreases Expression	[32]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Decreases Expression	[32]
BMP and activin membrane-bound inhibitor homolog (BAMBI)	OTCEJ8W5	BAMBI_HUMAN	Increases Expression	[32]
Dynactin subunit 2 (DCTN2)	OTMB4IXD	DCTN2_HUMAN	Increases Expression	[32]
Cullin-4A (CUL4A)	OTTBV70J	CUL4A_HUMAN	Decreases Expression	[32]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)	OT5UO1FA	HNRPD_HUMAN	Decreases Expression	[32]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13)	OTVDL515	GNA13_HUMAN	Increases Expression	[32]
Disco-interacting protein 2 homolog A (DIP2A)	OTXPTR8R	DIP2A_HUMAN	Decreases Expression	[32]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[32]
Kinesin-like protein KIF14 (KIF14)	OTXHT4JM	KIF14_HUMAN	Decreases Expression	[32]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Expression	[32]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[32]
MICOS complex subunit MIC60 (IMMT)	OTBDSLE7	MIC60_HUMAN	Affects Expression	[32]
WD40 repeat-containing protein SMU1 (SMU1)	OTLCSLGL	SMU1_HUMAN	Decreases Expression	[32]
Neuroblastoma breakpoint family member 1 (NBPF1)	OTAZ55UQ	NBPF1_HUMAN	Decreases Expression	[32]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON)	OT81X593	CDON_HUMAN	Decreases Expression	[32]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Decreases Expression	[32]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[32]
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3)	OTYBA69S	PAN3_HUMAN	Decreases Expression	[32]
Sterile alpha motif domain-containing protein 9 (SAMD9)	OTDG48P0	SAMD9_HUMAN	Increases Expression	[32]
Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B)	OT1VTUL9	P4R3B_HUMAN	Decreases Expression	[32]
Acyl-coenzyme A thioesterase THEM4 (THEM4)	OTSIZU8Y	THEM4_HUMAN	Decreases Expression	[32]
MAGUK p55 subfamily member 7 (MPP7)	OT3G3HTZ	MPP7_HUMAN	Increases Expression	[32]
DDB1- and CUL4-associated factor 8 (DCAF8)	OT3VFSLG	DCAF8_HUMAN	Decreases Expression	[32]
Collagen alpha-1(XIII) chain (COL13A1)	OTM9IM6J	CODA1_HUMAN	Increases Expression	[32]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)	OTDIBGQV	HECD2_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA)	OTCPFOSA	MRCKA_HUMAN	Decreases Expression	[32]
Rho GTPase-activating protein SYDE2 (SYDE2)	OTOEIXSM	SYDE2_HUMAN	Increases Expression	[32]
Deubiquitinase MYSM1 (MYSM1)	OTO73N00	MYSM1_HUMAN	Decreases Expression	[32]
AT-rich interactive domain-containing protein 2 (ARID2)	OTIRJXWM	ARID2_HUMAN	Decreases Expression	[32]
Glucose 1,6-bisphosphate synthase (PGM2L1)	OTSBNRT5	PGM2L_HUMAN	Increases Expression	[32]
UPF0547 protein C16orf87 (C16ORF87)	OT658H5A	CP087_HUMAN	Decreases Expression	[32]
Kelch-like protein 24 (KLHL24)	OTWZSX5C	KLH24_HUMAN	Increases Expression	[32]
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)	OTV01EFP	C1TM_HUMAN	Decreases Expression	[32]
Rho-related GTP-binding protein RhoU (RHOU)	OTERIAD4	RHOU_HUMAN	Increases Expression	[32]
Protein ABHD13 (ABHD13)	OTF2E8M6	ABHDD_HUMAN	Decreases Expression	[32]
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)	OT06BFRQ	G2E3_HUMAN	Decreases Expression	[32]
Diphthine--ammonia ligase (DPH6)	OTOJ7BXR	DPH6_HUMAN	Decreases Expression	[32]
Pogo transposable element with ZNF domain (POGZ)	OT4CYWC1	POGZ_HUMAN	Decreases Expression	[32]
FERM domain-containing protein 5 (FRMD5)	OTC73XJK	FRMD5_HUMAN	Decreases Expression	[32]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW)	OTT9SMTF	PIGW_HUMAN	Decreases Expression	[32]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Increases Expression	[32]
Dihydrofolate reductase 2, mitochondrial (DHFR2)	OTPHUWEY	DYR2_HUMAN	Decreases Expression	[32]
ELKS/Rab6-interacting/CAST family member 1 (ERC1)	OTYBGGNO	RB6I2_HUMAN	Decreases Expression	[32]
Armadillo repeat-containing protein 8 (ARMC8)	OTNAXGM7	ARMC8_HUMAN	Decreases Expression	[32]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)	OTNJX38T	M4K3_HUMAN	Decreases Expression	[32]
Protein FAM219A (FAM219A)	OTAFZHY9	F219A_HUMAN	Decreases Expression	[32]
Homeobox protein Mohawk (MKX)	OT7H7Z50	MKX_HUMAN	Decreases Expression	[32]
Threonine synthase-like 1 (THNSL1)	OTQNFH3E	THNS1_HUMAN	Decreases Expression	[32]
Porimin (TMEM123)	OTDMVZD6	PORIM_HUMAN	Decreases Expression	[32]
Rho guanine nucleotide exchange factor 39 (ARHGEF39)	OT9UKTQ5	ARG39_HUMAN	Decreases Expression	[32]
Type 2 DNA topoisomerase 6 subunit B-like (TOP6BL)	OTCYPUNK	TO6BL_HUMAN	Increases Expression	[32]
Protein SCAI (SCAI)	OTAK3TMO	SCAI_HUMAN	Decreases Expression	[32]
Diacylglycerol lipase-beta (DAGLB)	OT1S9869	DGLB_HUMAN	Decreases Expression	[32]
Regulator of G-protein signaling 22 (RGS22)	OTCTFGW6	RGS22_HUMAN	Decreases Expression	[32]
Phospholipase DDHD1 (DDHD1)	OTWTHOWK	DDHD1_HUMAN	Decreases Expression	[32]
Lysophosphatidylcholine acyltransferase 1 (LPCAT1)	OTCV7AGV	PCAT1_HUMAN	Decreases Expression	[32]
Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)	OTTD5FJ8	BD1L1_HUMAN	Decreases Expression	[32]
Atlastin-2 (ATL2)	OT93AUOO	ATLA2_HUMAN	Increases Expression	[32]
Centrosomal protein of 192 kDa (CEP192)	OTBLFV7T	CE192_HUMAN	Decreases Expression	[32]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[32]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Decreases Expression	[32]
Microprocessor complex subunit DGCR8 (DGCR8)	OT62LXE4	DGCR8_HUMAN	Decreases Expression	[32]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Affects Expression	[32]
Protein FAM3C (FAM3C)	OTBR6U9G	FAM3C_HUMAN	Decreases Expression	[32]
CREB-binding protein (CREBBP)	OTPA4QGM	CBP_HUMAN	Decreases Expression	[32]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Increases Expression	[32]
Homeobox protein DLX-4 (DLX4)	OTLWVCN4	DLX4_HUMAN	Increases Expression	[32]
Protein tyrosine phosphatase type IVA 1 (PTP4A1)	OTK0NFXJ	TP4A1_HUMAN	Decreases Expression	[32]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[32]
Exocyst complex component 4 (EXOC4)	OT5EWXAN	EXOC4_HUMAN	Decreases Expression	[32]
RalBP1-associated Eps domain-containing protein 1 (REPS1)	OTX4ERRK	REPS1_HUMAN	Decreases Expression	[32]
Protein LTV1 homolog (LTV1)	OTZILJDI	LTV1_HUMAN	Decreases Expression	[32]
PDZ and LIM domain protein 5 (PDLIM5)	OTLQVV22	PDLI5_HUMAN	Decreases Expression	[32]
DISP complex protein LRCH3 (LRCH3)	OTDLBLMU	LRCH3_HUMAN	Decreases Expression	[32]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Decreases Expression	[32]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Increases Expression	[32]
Mitochondrial inner membrane protease subunit 2 (IMMP2L)	OT9WGAFD	IMP2L_HUMAN	Decreases Expression	[32]
Transcription factor 12 (TCF12)	OTZVONNU	HTF4_HUMAN	Decreases Expression	[32]
ATP synthase subunit s, mitochondrial (DMAC2L)	OT2OQ1UD	ATP5S_HUMAN	Decreases Expression	[32]
Semaphorin-3C (SEMA3C)	OTEGUY7F	SEM3C_HUMAN	Increases Expression	[32]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2)	OT9P91XR	DPH2_HUMAN	Decreases Expression	[32]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)	OTB78IF4	ODC_HUMAN	Decreases Expression	[32]
Deubiquitinase DESI2 (DESI2)	OTHUOKOC	DESI2_HUMAN	Decreases Expression	[32]
Acireductone dioxygenase (ADI1)	OT8IOD03	MTND_HUMAN	Decreases Expression	[32]
Protein C1orf43 (C1ORF43)	OTT9CVZR	CA043_HUMAN	Decreases Expression	[32]
RNA-binding protein 24 (RBM24)	OTQI1AR1	RBM24_HUMAN	Increases Expression	[32]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[32]
E3 ubiquitin-protein ligase TRIM9 (TRIM9)	OTKYG33W	TRIM9_HUMAN	Increases Expression	[32]
E3 ubiquitin-protein ligase TRIM4 (TRIM4)	OTLKQNKQ	TRIM4_HUMAN	Increases Expression	[32]
Histone-lysine N-methyltransferase SETD5 (SETD5)	OTRPAVEO	SETD5_HUMAN	Decreases Expression	[32]
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)	OTXML85Y	FTO_HUMAN	Decreases Expression	[32]
Centrosomal protein of 295 kDa (CEP295)	OTVTTXRO	CE295_HUMAN	Decreases Expression	[32]
Sentrin-specific protease 6 (SENP6)	OT05LLF4	SENP6_HUMAN	Decreases Expression	[32]
Cytochrome c oxidase assembly factor 1 homolog (COA1)	OTHSX40F	COA1_HUMAN	Decreases Expression	[32]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)	OTH88TXU	ADA19_HUMAN	Increases Expression	[32]
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)	OTXV0ZD0	PHS2_HUMAN	Decreases Expression	[32]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Increases Expression	[32]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5)	OT2MNW8T	PKHA5_HUMAN	Decreases Expression	[32]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)	OTQDHSMI	MCCB_HUMAN	Decreases Expression	[32]
E3 ubiquitin-protein ligase SMURF1 (SMURF1)	OT5UIZR8	SMUF1_HUMAN	Affects Expression	[32]
Large ribosomal subunit protein mL65 (MRPS30)	OTDXIAGG	RT30_HUMAN	Decreases Expression	[32]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Decreases Expression	[32]
Muscleblind-like protein 1 (MBNL1)	OTOV7J85	MBNL1_HUMAN	Decreases Expression	[32]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[32]
Phenylalanine--tRNA ligase beta subunit (FARSB)	OT8N9TT5	SYFB_HUMAN	Decreases Expression	[32]
Midasin (MDN1)	OTNBSPTW	MDN1_HUMAN	Affects Expression	[32]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)	OT2H0MCE	TRM13_HUMAN	Decreases Expression	[32]
E3 ubiquitin-protein ligase RLIM (RLIM)	OTEBRNHJ	RNF12_HUMAN	Decreases Expression	[32]
G patch domain-containing protein 2-like (GPATCH2L)	OTETUZ64	GPT2L_HUMAN	Decreases Expression	[32]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)	OTFOJUIQ	PHAG1_HUMAN	Increases Expression	[32]
Huntingtin-interacting protein K (HYPK)	OTRWRVWN	HYPK_HUMAN	Affects Expression	[32]
Inhibitor of growth protein 3 (ING3)	OTDIJXFP	ING3_HUMAN	Decreases Expression	[32]
Rho guanine nucleotide exchange factor 12 (ARHGEF12)	OTM2D3LT	ARHGC_HUMAN	Decreases Expression	[32]
Cysteine-rich motor neuron 1 protein (CRIM1)	OTTZNV6Y	CRIM1_HUMAN	Decreases Expression	[32]
Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)	OTRH8X8A	CAC1I_HUMAN	Decreases Expression	[32]
eIF-2-alpha kinase GCN2 (EIF2AK4)	OTLE1JY8	E2AK4_HUMAN	Affects Expression	[32]
DNA polymerase kappa (POLK)	OTKZ38JH	POLK_HUMAN	Decreases Expression	[32]
Mediator of RNA polymerase II transcription subunit 13 (MED13)	OTP5LEJE	MED13_HUMAN	Decreases Expression	[32]
Jupiter microtubule associated homolog 1 (JPT1)	OT6CRZEU	JUPI1_HUMAN	Decreases Expression	[32]
BTB/POZ domain-containing protein 3 (BTBD3)	OTZ607YT	BTBD3_HUMAN	Decreases Expression	[32]
Thyroid hormone receptor-associated protein 3 (THRAP3)	OTG25JOG	TR150_HUMAN	Decreases Expression	[32]
rRNA-processing protein FCF1 homolog (FCF1)	OTTI9M2D	FCF1_HUMAN	Affects Expression	[32]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)	OTBCIBC7	SAMH1_HUMAN	Affects Expression	[32]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)	OTK53GUD	HS3SB_HUMAN	Increases Expression	[32]
Calcineurin-binding protein cabin-1 (CABIN1)	OT4G5CIK	CABIN_HUMAN	Decreases Expression	[32]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1)	OTY8J0S4	ZNT1_HUMAN	Decreases Expression	[32]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Increases Phosphorylation	[54]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[55]
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9)	OTM2T1FI	COQ9_HUMAN	Decreases Expression	[34]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Increases Expression	[56]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[57]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[56]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Secretion	[58]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Secretion	[59]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[60]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[57]
Protein kinase C beta type (PRKCB)	OTYQ0656	KPCB_HUMAN	Increases Phosphorylation	[59]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Affects Expression	[61]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Decreases Expression	[33]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[56]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Expression	[62]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[59]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[59]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[27]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Increases Phosphorylation	[59]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Activity	[60]
3-mercaptopyruvate sulfurtransferase (MPST)	OTCDPH5D	THTM_HUMAN	Decreases Expression	[34]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[63]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[34]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[56]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Decreases Expression	[56]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[64]
Protein kinase C iota type (PRKCI)	OTKBAVT3	KPCI_HUMAN	Increases Phosphorylation	[59]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Increases Phosphorylation	[63]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[65]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[66]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[34]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Activity	[55]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[57]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Expression	[67]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[34]
DNA-dependent protein kinase catalytic subunit (PRKDC)	OTJVS4EG	PRKDC_HUMAN	Increases Phosphorylation	[68]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Activity	[60]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Increases Phosphorylation	[59]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Increases Expression	[69]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[66]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Phosphorylation	[57]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Increases Activity	[70]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[66]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[56]
Extracellular tyrosine-protein kinase PKDCC (PKDCC)	OTVXJR26	PKDCC_HUMAN	Decreases Expression	[34]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[34]
Docking protein 6 (DOK6)	OTX55OIF	DOK6_HUMAN	Decreases Expression	[34]
tRNA-splicing endonuclease subunit Sen2 (TSEN2)	OT1UWYRI	SEN2_HUMAN	Decreases Expression	[34]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Decreases Expression	[34]
Probable ATP-dependent RNA helicase DDX17 (DDX17)	OTXRMMBP	DDX17_HUMAN	Decreases Expression	[34]
F-box/WD repeat-containing protein 5 (FBXW5)	OT5TQK3H	FBXW5_HUMAN	Increases Expression	[34]
PRKC apoptosis WT1 regulator protein (PAWR)	OTKY7W52	PAWR_HUMAN	Decreases Expression	[34]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Increases Expression	[59]
Homeobox protein HMX1 (HMX1)	OT65ZGE0	HMX1_HUMAN	Increases Expression	[34]
Abl interactor 2 (ABI2)	OT8GIIS5	ABI2_HUMAN	Decreases Expression	[34]
Inhibitor of Bruton tyrosine kinase (IBTK)	OTB2GM4G	IBTK_HUMAN	Decreases Expression	[34]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Increases Expression	[34]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Decreases Response To Substance	[71]
Phospholipid phosphatase 1 (PLPP1)	OT0IIMI5	PLPP1_HUMAN	Decreases Response To Substance	[71]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Increases Response To Substance	[71]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Response To Substance	[72]
Collagen alpha-1(VII) chain (COL7A1)	OT3MIRZJ	CO7A1_HUMAN	Decreases Response To Substance	[71]
Integrin alpha-E (ITGAE)	OT41KCRX	ITAE_HUMAN	Increases Response To Substance	[71]
Nicastrin (NCSTN)	OT5QBTA4	NICA_HUMAN	Affects Response To Substance	[70]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B)	OT8GTI1V	VATO_HUMAN	Increases Response To Substance	[71]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Affects Response To Substance	[73]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Increases ADR	[74]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Increases Response To Substance	[71]
Protein DBF4 homolog A (DBF4)	OTBL7JHQ	DBF4A_HUMAN	Increases Response To Substance	[71]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Response To Substance	[71]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Increases Response To Substance	[71]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)	OTD13PJN	RBMS1_HUMAN	Decreases Response To Substance	[71]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Increases Response To Substance	[71]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1)	OTEAAUBY	PBIP1_HUMAN	Decreases Response To Substance	[71]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Response To Substance	[75]
DNA mismatch repair protein Mlh1 (MLH1)	OTG5XDD8	MLH1_HUMAN	Affects Response To Substance	[73]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Increases Response To Substance	[71]
U6 snRNA-associated Sm-like protein LSm7 (LSM7)	OTHZ2XPX	LSM7_HUMAN	Increases Response To Substance	[71]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Increases Response To Substance	[71]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases Response To Substance	[71]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Decreases Response To Substance	[71]
Ras-related protein Rab-31 (RAB31)	OTMLXQZ0	RAB31_HUMAN	Decreases Response To Substance	[71]
Copper-transporting ATPase 1 (ATP7A)	OTMR3GXP	ATP7A_HUMAN	Decreases Response To Substance	[76]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4)	OTMWFDAC	AT2B4_HUMAN	Decreases Response To Substance	[71]
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1)	OTOTVMC8	CIP1_HUMAN	Increases Response To Substance	[71]
Protein FAM50B (FAM50B)	OTP3H38A	FA50B_HUMAN	Increases ADR	[77]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Increases Response To Substance	[71]
ATP-binding cassette sub-family B member 6 (ABCB6)	OTPGZFES	ABCB6_HUMAN	Decreases Response To Substance	[78]
E3 ubiquitin-protein ligase RNF34 (RNF34)	OTQY58LU	RNF34_HUMAN	Decreases Response To Substance	[65]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Increases Response To Substance	[71]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Response To Substance	[79]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Increases Response To Substance	[49]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Decreases Response To Substance	[80]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Response To Substance	[71]
Uncharacterized protein C8orf34 (C8ORF34)	OTXCTHDG	CH034_HUMAN	Increases ADR	[74]
Small nuclear ribonucleoprotein F (SNRPF)	OTZE5W6G	RUXF_HUMAN	Increases Response To Substance	[71]
Adenylate kinase 2, mitochondrial (AK2)	OTZG3X2H	KAD2_HUMAN	Increases Response To Substance	[71]

References

• [1] ClinicalTrials.gov (NCT05153239) Clinical Trial of Lurbinectedin as Single-agent or in Combination With Irinotecan Versus Topotecan or Irinotecan in Patients With Relapsed Small-cell Lung Cancer (LAGOON)
• [2] Topotecan FDA Label
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7101).
• [4] Plant-derived compounds in clinical trials. Drug Discov Today. 2008 Feb;13(3-4):161-71.
• [5] ClinicalTrials.gov (NCT00765973) Topotecan Liposomes Injection for Small Cell Lung Cancer (SCLC), Ovarian Cancer and Other Advanced Solid Tumors. U.S. National Institutes of Health.
• [6] Irinotecan FDA Label
• [7] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6823).
• [8] Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res. 2005 Jun 1;65(11):4775-81. doi: 10.1158/0008-5472.CAN-04-3332.
• [9] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [10] Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
• [11] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [12] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [13] Involvement of P-glycoprotein, multidrug resistance protein 2 and breast cancer resistance protein in the transport of belotecan and topotecan in Caco-2 and MDCKII cells. Pharm Res. 2008 Nov;25(11):2601-12.
• [14] Differential inhibition of murine Bcrp1/Abcg2 and human BCRP/ABCG2 by the mycotoxin fumitremorgin C. Eur J Pharmacol. 2010 Oct 10;644(1-3):41-8.
• [15] Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters. Biochem Pharmacol. 2007 Jul 15;74(2):359-71.
• [16] Topotecan is a substrate for multidrug resistance associated protein 4. Curr Drug Metab. 2006 Jan;7(1):105-18.
• [17] Chrysin blocks topotecan-induced apoptosis in Caco-2 cells in spite of inhibition of ABC-transporters. Biochem Pharmacol. 2010 Aug 15;80(4):471-9. doi: 10.1016/j.bcp.2010.04.038. Epub 2010 May 8.
• [18] Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Res. 1999 Dec 1;59(23):5938-46.
• [19] Cancer cell adaptation to chemotherapy. BMC Cancer. 2005 Jul 18;5:78.
• [20] The effect of Topotecan on oxidative stress in MCF-7 human breast cancer cell line. Acta Biochim Pol. 2005;52(4):897-902.
• [21] DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation. Mol Cell Biol. 2005 Jun;25(12):5040-51. doi: 10.1128/MCB.25.12.5040-5051.2005.
• [22] Tracking the cell cycle origins for escape from topotecan action by breast cancer cells. Br J Cancer. 2003 Apr 22;88(8):1310-7. doi: 10.1038/sj.bjc.6600889.
• [23] Human three prime exonuclease TREX1 is induced by genotoxic stress and involved in protection of glioma and melanoma cells to anticancer drugs. Biochim Biophys Acta. 2013 Aug;1833(8):1832-43. doi: 10.1016/j.bbamcr.2013.03.029. Epub 2013 Apr 8.
• [24] Effect of poly(ADP-ribose)polymerase and DNA topoisomerase I inhibitors on the p53/p63-dependent survival of carcinoma cells. Biochem Pharmacol. 2015 Apr 1;94(3):212-9. doi: 10.1016/j.bcp.2015.01.012. Epub 2015 Feb 7.
• [25] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [26] p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
• [27] Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
• [28] Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage. J Pharmacol Exp Ther. 2010 Jan;332(1):316-25. doi: 10.1124/jpet.109.159962. Epub 2009 Oct 7.
• [29] Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism. Drug Metab Dispos. 2007 Dec;35(12):2270-80.
• [30] Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene. Mol Pharmacol. 2005 May;67(5):1732-9.
• [31] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [32] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [33] Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. Anticancer Drugs. 2001 Oct;12(9):741-51. doi: 10.1097/00001813-200110000-00006.
• [34] Gene expression profile of colon cancer cell lines treated with SN-38. Chemotherapy. 2010;56(1):17-25. doi: 10.1159/000287353. Epub 2010 Feb 24.
• [35] UGT1A10 is responsible for SN-38 glucuronidation and its expression in human lung cancers. Anticancer Res. 2004 Sep-Oct;24(5A):2893-6.
• [36] Differential rates of glucuronidation for 7-ethyl-10-hydroxy-camptothecin (SN-38) lactone and carboxylate in human and rat microsomes and recombinant UDP-glucuronosyltransferase isoforms. Drug Metab Dispos. 2005 Jul;33(7):977-83. doi: 10.1124/dmd.104.003491. Epub 2005 Apr 15.
• [37] ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
• [38] Intestinal transport of irinotecan in Caco-2 cells and MDCK II cells overexpressing efflux transporters Pgp, cMOAT, and MRP1. Drug Metab Dispos. 2002 Jul;30(7):763-70.
• [39] Cyclosporin A, tacrolimus and sirolimus are potent inhibitors of the human breast cancer resistance protein (ABCG2) and reverse resistance to mitoxantrone and topotecan. Cancer Chemother Pharmacol. 2006 Sep;58(3):374-83.
• [40] P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
• [41] Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
• [42] Irinotecan and its active metabolite, SN-38: review of bioanalytical methods and recent update from clinical pharmacology perspectives. Biomed Chromatogr. 2010 Jan;24(1):104-23.
• [43] Pharmacogenetics of irinotecan metabolism and transport: an update. Toxicol In Vitro. 2006 Mar;20(2):163-75.
• [44] Drug Interactions Flockhart Table
• [45] Drugs that may have potential CYP2B6 interactions.
• [46] Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. Drug Metab Dispos. 2004 May;32(5):505-11.
• [47] Involvement of beta-glucuronidase in intestinal microflora in the intestinal toxicity of the antitumor camptothecin derivative irinotecan hydrochloride (CPT-11) in rats. Cancer Res. 1996 Aug 15;56(16):3752-7.
• [48] Transcriptional activation of the carboxylesterase 2 gene by the p53 pathway. Cancer Biol Ther. 2006 Nov;5(11):1450-6.
• [49] Concise prediction models of anticancer efficacy of 8 drugs using expression data from 12 selected genes. Int J Cancer. 2004 Sep 10;111(4):617-26. doi: 10.1002/ijc.20289.
• [50] A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor. J Pharmacol Exp Ther. 2006 Oct;319(1):82-104. doi: 10.1124/jpet.106.103606. Epub 2006 Jun 30.
• [51] Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. doi: 10.1097/FTD.0b013e3181357364.
• [52] Interaction of irinotecan (CPT-11) and its active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) with human cytochrome P450 enzymes. Drug Metab Dispos. 2002 Apr;30(4):391-6.
• [53] 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
• [54] Structure-guided evolution of potent and selective CHK1 inhibitors through scaffold morphing. J Med Chem. 2011 Dec 22;54(24):8328-42. doi: 10.1021/jm2007326. Epub 2011 Nov 23.
• [55] Chemotherapy and TRAIL-mediated colon cancer cell death: the roles of p53, TRAIL receptors, and c-FLIP. Mol Cancer Ther. 2005 Dec;4(12):2026-36. doi: 10.1158/1535-7163.MCT-05-0262.
• [56] The PPAR-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells. Chem Biol Interact. 2022 Jan 5;351:109712. doi: 10.1016/j.cbi.2021.109712. Epub 2021 Oct 23.
• [57] Irinotecan induces senescence and apoptosis in colonic cells in vitro. Toxicol Lett. 2012 Oct 2;214(1):1-8. doi: 10.1016/j.toxlet.2012.08.004. Epub 2012 Aug 14.
• [58] Ursolic and oleanolic acids in combination therapy inhibit migration of colon cancer cells through down-regulation of the uPA/uPAR-dependent MMPs pathway. Chem Biol Interact. 2022 Dec 1;368:110202. doi: 10.1016/j.cbi.2022.110202. Epub 2022 Oct 1.
• [59] Gefitinib ("Iressa", ZD1839) inhibits SN38-triggered EGF signals and IL-8 production in gastric cancer cells. Cancer Chemother Pharmacol. 2005 Apr;55(4):393-403. doi: 10.1007/s00280-004-0904-0. Epub 2004 Oct 5.
• [60] Pharmacological targeting of NF-kappaB potentiates the effect of the topoisomerase inhibitor CPT-11 on colon cancer cells. Br J Cancer. 2008 Jan 29;98(2):335-44. doi: 10.1038/sj.bjc.6604082. Epub 2008 Jan 8.
• [61] The expressions of p21 and pRB may be good indicators for the sensitivity of esophageal squamous cell cancers to CPT-11: Cell proliferation activity correlates with the effect of CPT-11. Cancer Sci. 2004 May;95(5):464-8. doi: 10.1111/j.1349-7006.2004.tb03233.x.
• [62] Sensitization of colorectal cancer to irinotecan therapy by PARP inhibitor rucaparib. Invest New Drugs. 2019 Oct;37(5):948-960. doi: 10.1007/s10637-018-00717-9. Epub 2019 Jan 5.
• [63] Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer. Cancer Res. 2005 Oct 1;65(19):8951-60. doi: 10.1158/0008-5472.CAN-05-0961.
• [64] Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors. Cell Cycle. 2012 May 1;11(9):1818-26. doi: 10.4161/cc.20208. Epub 2012 May 1.
• [65] Exogenous expression of hRFI induces multidrug resistance through escape from apoptosis in colorectal cancer cells. Anticancer Res. 2005 Jul-Aug;25(4):2737-41.
• [66] Enhancement of DNA topoisomerase I inhibitor-induced apoptosis by ursodeoxycholic acid. Mol Cancer Ther. 2006 Jan;5(1):68-79. doi: 10.1158/1535-7163.MCT-05-0107.
• [67] The histone-deacetylase inhibitor SAHA potentiates proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer Res Clin Oncol. 2005 Jun;131(6):385-94. doi: 10.1007/s00432-004-0664-6. Epub 2005 Mar 8.
• [68] DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation. Cancer Sci. 2007 Jun;98(6):858-63. doi: 10.1111/j.1349-7006.2007.00476.x. Epub 2007 Apr 18.
• [69] Irinotecan and DNA-PKcs inhibitors synergize in killing of colon cancer cells. Invest New Drugs. 2012 Jun;30(3):1248-56. doi: 10.1007/s10637-010-9626-9. Epub 2011 Jan 11.
• [70] gamma-Secretase inhibitors abrogate oxaliplatin-induced activation of the Notch-1 signaling pathway in colon cancer cells resulting in enhanced chemosensitivity. Cancer Res. 2009 Jan 15;69(2):573-82. doi: 10.1158/0008-5472.CAN-08-2088.
• [71] Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
• [72] Role of bile salt in regulating Mcl-1 phosphorylation and chemoresistance in hepatocellular carcinoma cells. Mol Cancer. 2011 Apr 20;10:44. doi: 10.1186/1476-4598-10-44.
• [73] Oncoprotein Bcl-2 and microsatellite instability are associated with disease-free survival and treatment response in colorectal cancer. Oncol Rep. 2008 Nov;20(5):999-1004.
• [74] A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer. Pharmacogenomics J. 2013 Oct;13(5):417-22. doi: 10.1038/tpj.2012.24. Epub 2012 Jun 5.
• [75] Potentiation of chemotherapeutic agents following antagonism of nuclear factor kappa B in human gliomas. J Neurooncol. 2003 Feb;61(3):187-96. doi: 10.1023/a:1022554824129.
• [76] Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
• [77] Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. Cancer Sci. 2013 Aug;104(8):1074-82. doi: 10.1111/cas.12186. Epub 2013 Jun 10.
• [78] Expression of ABCB6 is related to resistance to 5-FU, SN-38 and vincristine. Anticancer Res. 2014 Sep;34(9):4767-73.
• [79] Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2. Mol Pharmacol. 2007 Sep;72(3):686-94. doi: 10.1124/mol.107.036889. Epub 2007 May 30.
• [80] Drg1 expression in 131 colorectal liver metastases: correlation with clinical variables and patient outcomes. Clin Cancer Res. 2005 May 1;11(9):3296-302. doi: 10.1158/1078-0432.CCR-04-2417.