Details of the Drug Combination

General Information of Drug Combination (ID: DCYRLAY)

Drug Combination Name
Lucanthone Ruxolitinib
Indication
Disease Entry Status REF
Hodgkin lymphoma Investigative [1]
Component Drugs Lucanthone   DMZLBUO Ruxolitinib   DM7Q98D
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: L-1236
Zero Interaction Potency (ZIP) Score: 3.95
Bliss Independence Score: 0.416
Loewe Additivity Score: 1.502
LHighest Single Agent (HSA) Score: 2.082

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Lucanthone
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Approved [2]
Lucanthone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Inhibitor [10]
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Lucanthone Interacts with 196 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Serine/threonine-protein kinase PLK4 (PLK4) OTV8KZDZ PLK4_HUMAN Decreases Expression [9]
Nuclear envelope integral membrane protein 1 (NEMP1) OTWN3S47 NEMP1_HUMAN Decreases Expression [9]
Citron Rho-interacting kinase (CIT) OTOZDKPG CTRO_HUMAN Decreases Expression [9]
Kinetochore protein NDC80 homolog (NDC80) OTS7D306 NDC80_HUMAN Decreases Expression [9]
Aurora kinase A (AURKA) OTMX0HYT AURKA_HUMAN Decreases Expression [9]
Calmegin (CLGN) OTEWVFQV CLGN_HUMAN Decreases Expression [9]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [9]
D-3-phosphoglycerate dehydrogenase (PHGDH) OT1LMRTG SERA_HUMAN Decreases Expression [9]
Protein regulator of cytokinesis 1 (PRC1) OTHD0XS0 PRC1_HUMAN Decreases Expression [9]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1) OT80DZMT BUB1_HUMAN Decreases Expression [9]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B) OT8KME51 BUB1B_HUMAN Decreases Expression [9]
Hyaluronan mediated motility receptor (HMMR) OT4M0JTZ HMMR_HUMAN Decreases Expression [9]
Cell division control protein 45 homolog (CDC45) OT6NNLOD CDC45_HUMAN Decreases Expression [9]
G2/mitotic-specific cyclin-B2 (CCNB2) OTIEXTDK CCNB2_HUMAN Decreases Expression [9]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15) OTNGA2BW TNF15_HUMAN Increases Expression [9]
Kinesin-like protein KIF20A (KIF20A) OTXOQHE0 KI20A_HUMAN Decreases Expression [9]
Chromosome-associated kinesin KIF4A (KIF4A) OT3UWL7D KIF4A_HUMAN Decreases Expression [9]
Claudin-1 (CLDN1) OT27KV99 CLD1_HUMAN Decreases Expression [9]
Cystatin-SN (CST1) OTE4I83Q CYTN_HUMAN Increases Expression [9]
C-X-C motif chemokine 10 (CXCL10) OTTLQ6S0 CXL10_HUMAN Increases Expression [9]
Interstitial collagenase (MMP1) OTI4I2V1 MMP1_HUMAN Increases Expression [9]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [9]
Histone H2A type 1-B/E (H2AC4) OTMFQ662 H2A1B_HUMAN Decreases Expression [9]
Plasminogen activator inhibitor 2 (SERPINB2) OT72QLZB PAI2_HUMAN Increases Expression [9]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [9]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Increases Expression [9]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Expression [9]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [9]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Decreases Expression [9]
Cystatin-SA (CST2) OTRKRW50 CYTT_HUMAN Increases Expression [9]
Histone H2A type 1 (H2AC11) OTN9P0BO H2A1_HUMAN Decreases Expression [9]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [9]
Myb-related protein B (MYBL2) OTZ3JX8Q MYBB_HUMAN Decreases Expression [9]
Histone H1.4 (H1-4) OTQ450A3 H14_HUMAN Decreases Expression [9]
DNA topoisomerase 2-alpha (TOP2A) OT6LPS08 TOP2A_HUMAN Decreases Expression [9]
Annexin A3 (ANXA3) OTDD8OI7 ANXA3_HUMAN Decreases Expression [9]
Gamma-interferon-inducible lysosomal thiol reductase (IFI30) OT9DERT1 GILT_HUMAN Increases Expression [9]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [9]
Histone H1.5 (H1-5) OTAN7RD9 H15_HUMAN Decreases Expression [9]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Decreases Expression [9]
Stathmin (STMN1) OTDJ4RV0 STMN1_HUMAN Decreases Expression [9]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [9]
Interferon-induced GTP-binding protein Mx1 (MX1) OT6X8G5T MX1_HUMAN Increases Expression [9]
Filaggrin (FLG) OTE9QDV6 FILA_HUMAN Decreases Expression [9]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [9]
Integrin alpha-3 (ITGA3) OTBCH21D ITA3_HUMAN Increases Expression [9]
High mobility group protein B2 (HMGB2) OTGEGAOK HMGB2_HUMAN Decreases Expression [9]
Dipeptidyl peptidase 4 (DPP4) OT16MVL9 DPP4_HUMAN Increases Expression [9]
M-phase inducer phosphatase 3 (CDC25C) OTPQI71S MPIP3_HUMAN Decreases Expression [9]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Decreases Expression [9]
Guanylate-binding protein 1 (GBP1) OTUM7RPJ GBP1_HUMAN Decreases Expression [9]
Dual specificity protein kinase TTK (TTK) OTBY1Z5H TTK_HUMAN Decreases Expression [9]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Decreases Expression [9]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [9]
Neutral amino acid transporter A (SLC1A4) OTVODHAE SATT_HUMAN Decreases Expression [9]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Increases Expression [9]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [9]
Chemerin-like receptor 2 (CMKLR2) OTDNO0SL CML2_HUMAN Decreases Expression [9]
Tissue factor pathway inhibitor 2 (TFPI2) OTZCRWOR TFPI2_HUMAN Increases Expression [9]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [9]
Histone H3-like centromeric protein A (CENPA) OT0NEJ4X CENPA_HUMAN Decreases Expression [9]
Centromere protein F (CENPF) OT7AG0SW CENPF_HUMAN Decreases Expression [9]
DNA primase small subunit (PRIM1) OTWWP8Y6 PRI1_HUMAN Decreases Expression [9]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2) OT4DJFFU DNA2_HUMAN Decreases Expression [9]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase Nek2 (NEK2) OT1H27HO NEK2_HUMAN Decreases Expression [9]
Kinesin-like protein KIF11 (KIF11) OTHRGLCQ KIF11_HUMAN Decreases Expression [9]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [9]
RecQ-like DNA helicase BLM (BLM) OTEJOAJX BLM_HUMAN Decreases Expression [9]
DNA polymerase epsilon subunit 2 (POLE2) OTAC9V6L DPOE2_HUMAN Decreases Expression [9]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) OTNUPLUJ CKS1_HUMAN Decreases Expression [9]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Increases Expression [9]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [9]
Histone H2B type 1-C/E/F/G/I (H2BC10) OTLQH0D6 H2B1C_HUMAN Decreases Expression [9]
Histone H3.1 (H3C1) OTGBGOZW H31_HUMAN Decreases Expression [9]
Pregnancy-specific beta-1-glycoprotein 9 (PSG9) OT0UWPND PSG9_HUMAN Increases Expression [9]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1) OTCO26FV HMCS1_HUMAN Increases Expression [9]
Centromere-associated protein E (CENPE) OTQ7AP04 CENPE_HUMAN Decreases Expression [9]
Kinesin-like protein KIF23 (KIF23) OTY850JC KIF23_HUMAN Decreases Expression [9]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [9]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Increases Expression [9]
Forkhead box protein M1 (FOXM1) OT5887KR FOXM1_HUMAN Decreases Expression [9]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) OTZVUOOB FBLN3_HUMAN Decreases Expression [9]
Cell division cycle protein 20 homolog (CDC20) OTCOEZRV CDC20_HUMAN Decreases Expression [9]
Interleukin-24 (IL24) OT4VUWH1 IL24_HUMAN Increases Expression [9]
Pregnancy-specific beta-1-glycoprotein 7 (PSG7) OT1IXGBX PSG7_HUMAN Increases Expression [9]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1) OTXNGZCG MD2L1_HUMAN Decreases Expression [9]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1) OTGM06VJ IDI1_HUMAN Increases Expression [9]
Interleukin-18 (IL18) OTBB2A8O IL18_HUMAN Decreases Expression [9]
Separin (ESPL1) OTMGEVOK ESPL1_HUMAN Decreases Expression [9]
Maternal embryonic leucine zipper kinase (MELK) OTEY2UQA MELK_HUMAN Decreases Expression [9]
Kinesin-like protein KIF22 (KIF22) OTY6X6BL KIF22_HUMAN Decreases Expression [9]
Transmembrane glycoprotein NMB (GPNMB) OTB7KQKV GPNMB_HUMAN Increases Expression [9]
Condensin complex subunit 2 (NCAPH) OTXOS97C CND2_HUMAN Decreases Expression [9]
PCNA-associated factor (PCLAF) OTMVIOUU PAF15_HUMAN Decreases Expression [9]
Kinesin-like protein KIF14 (KIF14) OTXHT4JM KIF14_HUMAN Decreases Expression [9]
Pregnancy-specific beta-1-glycoprotein 5 (PSG5) OTHTU98X PSG5_HUMAN Increases Expression [9]
Delta(24)-sterol reductase (DHCR24) OTP301JW DHC24_HUMAN Increases Expression [9]
Disks large-associated protein 5 (DLGAP5) OTWCN39U DLGP5_HUMAN Decreases Expression [9]
Methylsterol monooxygenase 1 (MSMO1) OTKV62RZ MSMO1_HUMAN Increases Expression [9]
Histone-lysine N-methyltransferase EZH2 (EZH2) OTIEHTKW EZH2_HUMAN Decreases Expression [9]
Cyclin-dependent kinase inhibitor 3 (CDKN3) OTBE3H07 CDKN3_HUMAN Decreases Expression [9]
DNA excision repair protein ERCC-6-like (ERCC6L) OTE9V7D9 ERC6L_HUMAN Decreases Expression [9]
Chromosome-associated kinesin KIF4B (KIF4B) OTCLIB57 KIF4B_HUMAN Decreases Expression [9]
Inactive Rho GTPase-activating protein 11B (ARHGAP11B) OT6752M0 RHGBB_HUMAN Decreases Expression [9]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2) OTCH86VF AL1L2_HUMAN Decreases Expression [9]
Centrosomal protein of 55 kDa (CEP55) OTGSG2PA CEP55_HUMAN Decreases Expression [9]
Quinone oxidoreductase PIG3 (TP53I3) OTSCM68G QORX_HUMAN Increases Expression [9]
Shugoshin 2 (SGO2) OTNGJDS8 SGO2_HUMAN Decreases Expression [9]
N-acetyltransferase ESCO2 (ESCO2) OTJEMAQU ESCO2_HUMAN Decreases Expression [9]
Shugoshin 1 (SGO1) OTIP6IRN SGO1_HUMAN Decreases Expression [9]
DEP domain-containing protein 1A (DEPDC1) OT0JWE1B DEP1A_HUMAN Decreases Expression [9]
Protein lin-9 homolog (LIN9) OTLHW00C LIN9_HUMAN Decreases Expression [9]
Protein FAM72A (FAM72A) OTBZYSR3 FA72A_HUMAN Decreases Expression [9]
Cell division cycle-associated protein 2 (CDCA2) OTX8UF9J CDCA2_HUMAN Decreases Expression [9]
Mitochondrial fission regulator 2 (MTFR2) OTLOR68D MTFR2_HUMAN Decreases Expression [9]
Rho GTPase-activating protein 11A (ARHGAP11A) OTVQCFVP RHGBA_HUMAN Decreases Expression [9]
ATPase family AAA domain-containing protein 2 (ATAD2) OT8MCRNY ATAD2_HUMAN Decreases Expression [9]
SHC-transforming protein 4 (SHC4) OTQ0H76H SHC4_HUMAN Increases Expression [9]
Lysophospholipid acyltransferase 1 (MBOAT1) OT4XR6TE MBOA1_HUMAN Decreases Expression [9]
Patched domain-containing protein 4 (PTCHD4) OTGJ8NRP PTHD4_HUMAN Increases Expression [9]
Histone H3.2 (H3C13) OT97FS6C H32_HUMAN Decreases Expression [9]
Centromere protein U (CENPU) OTQ4TZRS CENPU_HUMAN Decreases Expression [9]
Protein MCM10 homolog (MCM10) OTV0O3JN MCM10_HUMAN Decreases Expression [9]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Increases Expression [9]
Glucosylceramide transporter ABCA12 (ABCA12) OTKH9YQZ ABCAC_HUMAN Increases Expression [9]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3) OT4RZV2M IQGA3_HUMAN Decreases Expression [9]
Condensin-2 complex subunit G2 (NCAPG2) OTZYENKO CNDG2_HUMAN Decreases Expression [9]
Histone H2A type 2-B (H2AC21) OTH7W2NJ H2A2B_HUMAN Decreases Expression [9]
Dynein axonemal intermediate chain 3 (DNAI3) OTG1A0QP DNAI3_HUMAN Increases Expression [9]
Extracellular sulfatase Sulf-2 (SULF2) OTIXMUVL SULF2_HUMAN Increases Expression [9]
Signal peptide, CUB and EGF-like domain-containing protein 1 (SCUBE1) OT4JY1UY SCUB1_HUMAN Increases Expression [9]
Cytoskeleton-associated protein 2-like (CKAP2L) OT4T73GG CKP2L_HUMAN Decreases Expression [9]
E3 ubiquitin-protein ligase TRIM22 (TRIM22) OTJBLG5R TRI22_HUMAN Increases Expression [9]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Decreases Expression [9]
Centromere protein L (CENPL) OT7P006B CENPL_HUMAN Decreases Expression [9]
T-complex protein 11-like protein 2 (TCP11L2) OTTIZO7B T11L2_HUMAN Increases Expression [9]
Holliday junction recognition protein (HJURP) OTWMV16B HJURP_HUMAN Decreases Expression [9]
SHC SH2 domain-binding protein 1 (SHCBP1) OT3A21CM SHCBP_HUMAN Decreases Expression [9]
Kinetochore scaffold 1 (KNL1) OT4Q3LHV KNL1_HUMAN Decreases Expression [9]
Mitochondria-eating protein (SPATA18) OTOEHTHU MIEAP_HUMAN Increases Expression [9]
Protein CIP2A (CIP2A) OTVS2GXA CIP2A_HUMAN Decreases Expression [9]
Probable glutathione peroxidase 8 (GPX8) OTTH80PN GPX8_HUMAN Decreases Expression [9]
DEP domain-containing protein 1B (DEPDC1B) OTMVFOT1 DEP1B_HUMAN Decreases Expression [9]
Secreted and transmembrane protein 1 (SECTM1) OT5500CF SCTM1_HUMAN Increases Expression [9]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [9]
Peroxidasin homolog (PXDN) OTFGGM9R PXDN_HUMAN Increases Expression [9]
Centromere protein I (CENPI) OTWRIMZ3 CENPI_HUMAN Decreases Expression [9]
Histone H2B type 1-H (H2BC9) OTQ9XX72 H2B1H_HUMAN Decreases Expression [9]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [9]
RAD51-associated protein 1 (RAD51AP1) OTXM7UTD R51A1_HUMAN Decreases Expression [9]
Exosome complex component RRP43 (EXOSC8) OT75ACNG EXOS8_HUMAN Decreases Expression [9]
Ubiquitin thioesterase OTUB2 (OTUB2) OTZUMPH2 OTUB2_HUMAN Increases Expression [9]
Protein Spindly (SPDL1) OTI0JNTM SPDLY_HUMAN Decreases Expression [9]
Molybdenum cofactor sulfurase (MOCOS) OT0TL3Q5 MOCOS_HUMAN Decreases Expression [9]
Aurora kinase B (AURKB) OTIY4VHU AURKB_HUMAN Decreases Expression [9]
Proline-rich protein 11 (PRR11) OT2JJ08Z PRR11_HUMAN Decreases Expression [9]
Lymphokine-activated killer T-cell-originated protein kinase (PBK) OT5Z27TW TOPK_HUMAN Decreases Expression [9]
Histone H2A type 1-H (H2AC12) OTLXVB97 H2A1H_HUMAN Decreases Expression [9]
Uncharacterized protein C5orf34 (C5ORF34) OTT2ESR4 CE034_HUMAN Decreases Expression [9]
Kinesin-like protein KIF20B (KIF20B) OTS68AHH KI20B_HUMAN Decreases Expression [9]
Sperm-associated antigen 5 (SPAG5) OTCLJ56M SPAG5_HUMAN Decreases Expression [9]
Kinesin-like protein KIF2C (KIF2C) OTJ8G3NP KIF2C_HUMAN Decreases Expression [9]
Cell division control protein 6 homolog (CDC6) OTX93FE7 CDC6_HUMAN Decreases Expression [9]
Histone H2A type 1-J (H2AC14) OT5Y4MMC H2A1J_HUMAN Decreases Expression [9]
Histone H2B type 1-M (H2BC14) OTSDZZZY H2B1M_HUMAN Decreases Expression [9]
Growth/differentiation factor 15 (GDF15) OTWQN50N GDF15_HUMAN Increases Expression [9]
Condensin complex subunit 3 (NCAPG) OT1AI9EO CND3_HUMAN Decreases Expression [9]
Centromere protein K (CENPK) OTKPUF8K CENPK_HUMAN Decreases Expression [9]
Latexin (LXN) OTZQ2M6Y LXN_HUMAN Increases Expression [9]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [9]
Meiotic nuclear division protein 1 homolog (MND1) OTS87F3H MND1_HUMAN Decreases Expression [9]
GTP-binding protein 2 (GTPBP2) OTOJ1KUA GTPB2_HUMAN Decreases Expression [9]
Nucleolar and spindle-associated protein 1 (NUSAP1) OT85HIJ5 NUSAP_HUMAN Decreases Expression [9]
Kinetochore protein Nuf2 (NUF2) OTOOQL35 NUF2_HUMAN Decreases Expression [9]
Protein Niban 1 (NIBAN1) OTYOLI12 NIBA1_HUMAN Decreases Expression [9]
Rac GTPase-activating protein 1 (RACGAP1) OTQE8IEH RGAP1_HUMAN Decreases Expression [9]
Protein ECT2 (ECT2) OTQDUCT6 ECT2_HUMAN Decreases Expression [9]
Kinetochore protein Spc25 (SPC25) OTCAS0OH SPC25_HUMAN Decreases Expression [9]
Anillin (ANLN) OTXJY54C ANLN_HUMAN Decreases Expression [9]
Kinesin-like protein KIF15 (KIF15) OTJRJEXL KIF15_HUMAN Decreases Expression [9]
Protein diaphanous homolog 3 (DIAPH3) OTPOT23F DIAP3_HUMAN Decreases Expression [9]
Structural maintenance of chromosomes protein 4 (SMC4) OTEJE6AG SMC4_HUMAN Decreases Expression [9]
Fanconi anemia group I protein (FANCI) OTW8E3SC FANCI_HUMAN Decreases Expression [9]
Transmembrane protein 45A (TMEM45A) OT54KJG6 TM45A_HUMAN Increases Expression [9]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Decreases Expression [9]
Homologous-pairing protein 2 homolog (PSMC3IP) OT9UB5UO HOP2_HUMAN Decreases Expression [9]
DNA helicase MCM8 (MCM8) OTC93H3S MCM8_HUMAN Decreases Expression [9]
F-box only protein 5 (FBXO5) OTTR957W FBX5_HUMAN Decreases Expression [9]
Targeting protein for Xklp2 (TPX2) OTWLJYH0 TPX2_HUMAN Decreases Expression [9]
Exonuclease 1 (EXO1) OTI87RS5 EXO1_HUMAN Decreases Expression [9]
Calcium-activated chloride channel regulator 2 (CLCA2) OTF191LZ CLCA2_HUMAN Increases Expression [9]
Lysosome-associated membrane glycoprotein 3 (LAMP3) OTN0XL3W LAMP3_HUMAN Decreases Expression [9]
Origin recognition complex subunit 6 (ORC6) OTKQN3KP ORC6_HUMAN Decreases Expression [9]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Decreases Expression [9]
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⏷ Show the Full List of 196 DOT(s)
Indication(s) of Ruxolitinib
Disease Entry ICD 11 Status REF
Essential thrombocythemia 3B63.1Z Approved [3]
High-risk myelofibrosis 2A20.2 Approved [4]
Myelofibrosis 2A22 Approved [5]
Myeloproliferative neoplasm 2A20 Approved [6]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [7]
Pancreatic cancer 2C10 Phase 3 [4]
Atopic dermatitis EA80 Phase 1/2 [8]
Vitiligo ED63.0 Phase 1/2 [8]
Ruxolitinib Interacts with 5 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Janus kinase 2 (JAK-2) TTRMX3V JAK2_HUMAN Modulator [11]
Janus kinase 1 (JAK-1) TT6DM01 JAK1_HUMAN Modulator [11]
Urokinase plasminogen activator surface receptor (PLAUR) TTPRL03 UPAR_HUMAN Inhibitor [12]
HUMAN janus kinase 1 (JAK-1) TTWKB01 JAK1_HUMAN Inhibitor [13]
HUMAN janus kinase 2 (JAK-2) TT0F5HE JAK2_HUMAN Inhibitor [13]
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Ruxolitinib Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Mitogen-activated protein kinase 14 (MAPK14) OT5TCO3O MK14_HUMAN Increases ADR [14]
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References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Drug information of Lucanthone, 2008. eduDrugs.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5688).
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 Ruxolitinib FDA Label
7 Incyte begins Phase III trial of ruxolitinib to treat Covid-19. 20.April.2020.
8 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
9 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
10 Clonogenicity of human leukemic cells protected from cell-lethal agents by heat shock protein 70. Cell Stress Chaperones. 2005 Spring;10(1):37-45.
11 2011 FDA drug approvals. Nat Rev Drug Discov. 2012 Feb 1;11(2):91-4.
12 Urokinase-type plasminogen activator receptor signaling is critical in nasopharyngeal carcinoma cell growth and metastasis.Cell Cycle. 2014;13(12):1958-69.
13 The Use of Anti-Inflammatory Drugs in the Treatment of People With Severe Coronavirus Disease 2019 (COVID-19): The Perspectives of Clinical Immunologists From China. Clin Immunol. 2020 May;214:108393.
14 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.