Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMYRUH2)

• Drug Name: I-BET151 Drug Info
• Synonyms: GSK1210151A

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 52912189
  ChEBI ID: CHEBI:95083
  CAS Number: CAS 1300031-49-5
  TTD Drug ID: DMYRUH2

Molecule-Related Drug Atlas

Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[6]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[6]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[7]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[6]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[7]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[7]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[8]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[6]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[6]
AZD5153	DMW4GM2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]

Drug(s) Targeting Bromodomain-containing protein 3 (BRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[7]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[9]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[9]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[10]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[11]
PMID24000170C36	DMHUWZS	Discovery agent	N.A.	Investigative	[12]
PMID24000170C38	DMOLRIY	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[6]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[7]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[9]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[9]
PMID26924192-Compound-106	DM9HRZJ	N. A.	N. A.	Patented	[9]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[10]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[11]

Drug(s) Affected By Protein HEXIM1 (HEXIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[23]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[34]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[43]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[44]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[54]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[55]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[56]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[57]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[60]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[64]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[66]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[67]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[68]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[71]
Fructose	DM43AN2	Vomiting	MD90	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[76]
Selenium	DM25CGV	N. A.	N. A.	Approved	[77]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[81]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[82]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[87]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[94]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[97]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[99]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[103]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[115]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]

Drug(s) Affected By N-myc proto-oncogene protein (MYCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[126]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[127]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[128]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[128]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[75]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[129]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[132]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[133]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[134]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Fructose	DM43AN2	Vomiting	MD90	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[73]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[149]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[151]

Drug(s) Affected By Integrin alpha-5 (ITGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[154]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[156]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[157]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[158]

Drug(s) Affected By Protein L-Myc (MYCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[165]

Drug(s) Affected By Intercellular adhesion molecule 2 (ICAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[163]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[167]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[165]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[172]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[173]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[73]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[174]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[25]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[55]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[178]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[181]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[50]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[182]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[163]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[149]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[183]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[151]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[186]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[74]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[187]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[190]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[192]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]

Drug(s) Affected By Protein-lysine 6-oxidase (LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[163]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[108]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[197]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[158]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[198]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[201]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]

Drug(s) Affected By Integrin alpha-1 (ITGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[182]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[209]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[210]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[206]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[216]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[206]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[218]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[206]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[219]

Drug(s) Affected By Lysyl oxidase homolog 1 (LOXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[222]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[166]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[3]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[198]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[225]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[159]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[70]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[198]
Bortezomib	DMNO38U	Leukemia		Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[230]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[232]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[197]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[179]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[197]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[236]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[236]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[15]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[230]

Drug(s) Affected By Platelet-derived growth factor C (PDGFC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[50]

Drug(s) Affected By Lysyl oxidase homolog 2 (LOXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[46]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[112]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[241]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[151]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain-containing protein 2 (BRD2)	TTDP48B	BRD2_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 3 (BRD3)	TTHE657	BRD3_HUMAN	Inhibitor	[1]
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3)	OT25JBA3	F263_HUMAN	Gene/Protein Processing	[2]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[3]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Gene/Protein Processing	[4]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[4]
Carbonic anhydrase 9 (CA9)	OTNA51XT	CAH9_HUMAN	Gene/Protein Processing	[2]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Gene/Protein Processing	[3]
Collagen alpha-1(V) chain (COL5A1)	OT24078H	CO5A1_HUMAN	Gene/Protein Processing	[3]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Gene/Protein Processing	[3]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Gene/Protein Processing	[5]

References

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