Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMO58UW)

• Drug Name: methyl p-hydroxybenzoate Drug Info
• Synonyms: methylparaben; nipagin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 7456
  ChEBI ID: CHEBI:31835
  CAS Number: CAS 99-76-3
  TTD Drug ID: DMO58UW

Molecule-Related Drug Atlas

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[5]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[6]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[7]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[8]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[9]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[10]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[11]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[12]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[13]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[14]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[15]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[17]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[17]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[20]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[22]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[17]

Drug(s) Affected By Glutamate-rich protein 2 (ERICH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]

Drug(s) Affected By CBY1-interacting BAR domain-containing protein 1 (CIBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[32]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[33]

Drug(s) Affected By Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[34]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[23]

Drug(s) Affected By Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By IgA-inducing protein homolog (IGIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 12 (PSMD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[58]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[63]

Drug(s) Affected By ATP-dependent RNA helicase DDX3X (DDX3X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]

Drug(s) Affected By Transcription factor E2F3 (E2F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[77]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]

Drug(s) Affected By Suppressor of cytokine signaling 7 (SOCS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Histone-lysine N-methyltransferase 2D (KMT2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Transcription elongation regulator 1 (TCERG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[98]

Drug(s) Affected By Kinetochore protein NDC80 homolog (NDC80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]

Drug(s) Affected By Regulator of G-protein signaling 12 (RGS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Myosin regulatory light chain 12B (MYL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[110]

Drug(s) Affected By Granule associated Rac and RHOG effector protein 1 (GARRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 2 (ARPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[113]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[114]

Drug(s) Affected By Centrin-3 (CETN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[117]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[118]

Drug(s) Affected By Protein RER1 (RER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Inositol polyphosphate 4-phosphatase type II (INPP4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit H (EIF3H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By Importin-8 (IPO8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[125]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[126]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[127]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[135]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[136]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By ATP-dependent RNA helicase DHX15 (DHX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[145]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[146]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[147]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[152]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[156]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[157]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]

Drug(s) Affected By Carbohydrate sulfotransferase 1 (CHST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[161]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Ibrolipim	DMOPWSX	Hyperlipidaemia	5C80	Phase 2	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Origin recognition complex subunit 4 (ORC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Protein SOX-15 (SOX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[168]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By Sushi domain-containing protein 5 (SUSD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]

Drug(s) Affected By H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Peroxisomal membrane protein PEX14 (PEX14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[186]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[187]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[184]

Drug(s) Affected By Serine/arginine-rich splicing factor 10 (SRSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[189]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[174]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Protein phosphatase 1B (PPM1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]

Drug(s) Affected By Carbonyl reductase 3 (CBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[199]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[200]

Drug(s) Affected By Isocitrate dehydrogenase cytoplasmic (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By Serine hydrolase RBBP9 (RBBP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[203]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By ATP synthase subunit g, mitochondrial (ATP5MG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By G antigen 7 (GAGE7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[210]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[211]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[212]

Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 2 (GFPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[146]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[215]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[217]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[218]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]

Drug(s) Affected By Serine protease 23 (PRSS23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[147]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]

Drug(s) Affected By SR-related and CTD-associated factor 4 (SCAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[223]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Chromosome-associated kinesin KIF4A (KIF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Histone acetyltransferase KAT7 (KAT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]

Drug(s) Affected By Transmembrane protein 50A (TMEM50A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[226]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[226]

Drug(s) Affected By BAG family molecular chaperone regulator 2 (BAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[77]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[228]

Drug(s) Affected By Quinone oxidoreductase-like protein 1 (CRYZL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[229]

Drug(s) Affected By T-box transcription factor TBX18 (TBX18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]
Manganese	DMKT129	N. A.	N. A.	Investigative	[230]

Drug(s) Affected By Cytochrome b (CYTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Fialuridine	DMCIGRB	Hepatitis B virus infection	1E51.0	Phase 2	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[237]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[241]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[243]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[246]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]

Drug(s) Affected By Cytochrome c oxidase subunit 3 (COX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[247]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[249]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[249]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[250]

Drug(s) Affected By ATP synthase subunit a (ATP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[248]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[256]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[257]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[262]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[265]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[270]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[274]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[275]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[277]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[278]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[281]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[282]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[285]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[281]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[286]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 2 (ND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[287]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[288]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 3 (ND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Fialuridine	DMCIGRB	Hepatitis B virus infection	1E51.0	Phase 2	[233]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By ATP synthase protein 8 (ATP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[291]
Haloperidol	DM96SE0	Delirium		Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[294]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[298]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[302]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[300]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[305]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Fructose	DM43AN2	Vomiting	MD90	Approved	[307]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[308]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[309]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[309]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[309]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[309]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[317]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[318]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[318]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[324]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[325]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[328]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[329]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[331]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[305]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[332]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[336]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[337]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[342]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[344]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[342]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[345]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[346]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[128]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[349]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[353]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[355]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[356]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[358]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[359]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[360]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[361]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[362]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[58]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[140]

Drug(s) Affected By Signal recognition particle receptor subunit alpha (SRPRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Haloperidol	DM96SE0	Delirium		Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[211]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[364]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[365]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[365]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[366]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[365]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[367]
Selenium	DM25CGV	N. A.	N. A.	Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[371]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[260]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[372]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[373]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Homeobox protein Hox-C4 (HOXC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[375]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[168]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[376]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[378]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[171]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[381]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[382]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[383]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[384]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[385]
Selenium	DM25CGV	N. A.	N. A.	Approved	[386]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[387]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[392]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[349]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[395]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[396]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[394]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[397]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[398]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[399]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[400]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[401]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[402]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[403]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[404]

Drug(s) Affected By cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[405]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[406]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[407]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[408]

Drug(s) Affected By S-formylglutathione hydrolase (ESD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[379]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[410]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[412]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[413]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[339]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[414]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[415]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[416]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[417]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[418]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[419]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[420]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[421]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[422]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]

Drug(s) Affected By Alcohol dehydrogenase class-3 (ADH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[425]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[426]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[427]
Selenium	DM25CGV	N. A.	N. A.	Approved	[336]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[429]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[430]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]

Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[431]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[432]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[433]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[431]

Drug(s) Affected By Xaa-Pro dipeptidase (PEPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[436]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]

Drug(s) Affected By Secretogranin-2 (SCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[437]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[438]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[440]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[441]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[431]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[442]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[444]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[445]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[445]

Drug(s) Affected By Protein disulfide-isomerase A4 (PDIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[447]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[448]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[449]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[449]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[449]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[450]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[449]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[412]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[451]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[421]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[336]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[337]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[453]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[454]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]

Drug(s) Affected By Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[455]
Selenium	DM25CGV	N. A.	N. A.	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[456]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[457]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]

Drug(s) Affected By Prolactin receptor (PRLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[459]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[331]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[29]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[461]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]

Drug(s) Affected By Ganglioside GM2 activator (GM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[264]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[84]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[462]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[463]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[464]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[391]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[391]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[467]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[468]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[469]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[470]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[395]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[472]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[473]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[475]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[476]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]

Drug(s) Affected By Proteasome subunit beta type-1 (PSMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[478]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[211]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[211]

Drug(s) Affected By Trifunctional purine biosynthetic protein adenosine-3 (GART)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]

Drug(s) Affected By Calretinin (CALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[480]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[481]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[482]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[113]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Small ribosomal subunit protein uS3 (RPS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[483]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[484]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[485]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[404]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[486]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[489]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[490]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[475]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[453]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[476]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[492]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[493]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[494]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[335]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[496]
Selenium	DM25CGV	N. A.	N. A.	Approved	[336]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[453]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[497]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[421]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[499]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[500]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[500]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[501]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[502]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[502]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[503]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[110]
Bortezomib	DMNO38U	Leukemia		Approved	[506]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[507]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[508]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[509]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[403]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[510]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[511]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[512]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[513]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[514]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[503]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Collagen alpha-1(VIII) chain (COL8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[516]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[518]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[508]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[519]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[520]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[521]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[507]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[403]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[510]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[70]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[522]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]

Drug(s) Affected By Leiomodin-1 (LMOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[523]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[524]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[70]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[525]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[430]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[526]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[527]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[528]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[528]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[110]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]

Drug(s) Affected By Transmembrane 4 L6 family member 1 (TM4SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[470]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[470]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[530]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By Sorcin (SRI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[531]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[532]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[533]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[534]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[533]

Drug(s) Affected By Homeobox protein Hox-C8 (HOXC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[535]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[536]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[411]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H3 (HNRNPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[537]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[538]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Large ribosomal subunit protein uL6 (RPL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[408]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[539]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[412]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Gap junction alpha-4 protein (GJA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[542]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[543]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[29]

Drug(s) Affected By RNA-binding protein FUS (FUS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Signal recognition particle 14 kDa protein (SRP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[113]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By RNA-binding motif protein, X chromosome (RBMX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[547]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[548]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[549]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[550]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[551]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[552]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[421]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[553]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[337]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[554]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[453]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]

Drug(s) Affected By ADP-ribosylation factor-like protein 4A (ARL4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[555]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[556]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[557]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[559]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[555]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[555]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[560]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[561]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[562]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[546]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[563]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]

Drug(s) Affected By Isoleucine--tRNA ligase, cytoplasmic (IARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[450]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[140]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By ETS domain-containing protein Elk-3 (ELK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[564]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[211]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[565]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[566]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[567]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[568]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[569]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[570]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[571]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[572]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[573]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[574]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[575]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[320]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]

Drug(s) Affected By Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[577]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By Cathepsin O (CTSO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[29]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[578]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[579]

Drug(s) Affected By Chromobox protein homolog 5 (CBX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[581]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[156]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[582]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[583]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[584]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]

Drug(s) Affected By ATP synthase F(0) complex subunit C3, mitochondrial (ATP5MC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[207]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[585]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By DNA-binding protein RFX5 (RFX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[382]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[586]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[522]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[587]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[588]

Drug(s) Affected By Potassium voltage-gated channel subfamily C member 1 (KCNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[589]

Drug(s) Affected By Mannan-binding lectin serine protease 1 (MASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[590]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[590]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[591]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[443]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By Methionine aminopeptidase 2 (METAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[165]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[592]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
PMID27998201-Compound-22	DMS9QA7	Alzheimer disease	8A20	Patented	[593]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Diacylglycerol kinase epsilon (DGKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[594]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[595]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[29]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[95]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[438]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]

Drug(s) Affected By Ephrin-A4 (EFNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[523]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]

Drug(s) Affected By Coatomer subunit alpha (COPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By IST1 homolog (IST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[596]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[32]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[85]

Drug(s) Affected By Activated RNA polymerase II transcriptional coactivator p15 (SUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[597]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[598]

Drug(s) Affected By Arginine--tRNA ligase, cytoplasmic (RARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Paired mesoderm homeobox protein 1 (PRRX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[599]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Indomethacin	DMSC4A7	Bursitis		Approved	[437]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[437]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[600]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Bax inhibitor 1 (TMBIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[174]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[32]

Drug(s) Affected By Proteinase-activated receptor 2 (F2RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By AP-1 complex subunit sigma-2 (AP1S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[601]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Neurotrypsin (PRSS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[602]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[603]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[604]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[605]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[480]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit E (EIF3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[606]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[596]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By ATP-binding cassette sub-family E member 1 (ABCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[607]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[608]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Large ribosomal subunit protein eL43 (RPL37A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[610]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[611]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[612]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[613]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[614]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[615]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[616]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[523]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Ras-related protein Rab-11A (RAB11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[617]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[431]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[619]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[620]

Drug(s) Affected By Thymosin beta-10 (TMSB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[621]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Raltitrexed	DMT9K8G	Rectal adenocarcinoma	2B92	Approved	[622]

Drug(s) Affected By RNA-binding protein 6 (RBM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[23]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[224]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[623]

Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[624]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[409]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[625]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[626]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[627]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[469]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[628]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[629]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[630]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[174]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[427]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[631]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[632]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[476]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[633]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]

Drug(s) Affected By Receptor expression-enhancing protein 5 (REEP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[364]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[634]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]

Drug(s) Affected By Nucleolysin TIAR (TIAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[469]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[635]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[636]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[636]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[637]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[636]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[638]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[639]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[522]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[641]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[642]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[643]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[644]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Indomethacin	DMSC4A7	Bursitis		Approved	[645]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[600]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 10 (MAP3K10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[646]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[55]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[647]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[648]

Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]

Drug(s) Affected By Single-stranded DNA-binding protein, mitochondrial (SSBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[646]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[649]

Drug(s) Affected By Proteolipid protein 2 (PLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[211]

Drug(s) Affected By Islet cell autoantigen 1 (ICA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[579]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Serine/arginine-rich splicing factor 11 (SRSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[397]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[574]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[401]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[650]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[651]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[453]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[652]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[653]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[654]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[655]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[656]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[403]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[657]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[658]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[468]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[128]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[659]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[136]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Bortezomib	DMNO38U	Leukemia		Approved	[53]

Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[646]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[617]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[604]

Drug(s) Affected By Golgin subfamily A member 3 (GOLGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[379]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By Leukocyte surface antigen CD47 (CD47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]

Drug(s) Affected By Aspartyl/asparaginyl beta-hydroxylase (ASPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Haloperidol	DM96SE0	Delirium		Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[660]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[384]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[660]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[660]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[661]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[660]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[431]

Drug(s) Affected By Cell division cycle protein 16 homolog (CDC16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[77]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[662]

Drug(s) Affected By Serine/arginine-rich splicing factor 6 (SRSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Indomethacin	DMSC4A7	Bursitis		Approved	[663]

Drug(s) Affected By Polyadenylate-binding protein 4 (PABPC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[664]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[665]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[666]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[156]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[667]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[668]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[668]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[669]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[574]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[654]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[58]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[667]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[670]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[289]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[671]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[672]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[673]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[674]

Drug(s) Affected By High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[675]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Trequinsin	DMQRSMD	N. A.	N. A.	Terminated	[675]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[676]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 8 (LRP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[677]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[678]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[679]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[680]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[681]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]

Drug(s) Affected By Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIP12 (TRIP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Clathrin interactor 1 (CLINT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[682]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[682]
Bortezomib	DMNO38U	Leukemia		Approved	[53]

Drug(s) Affected By DNA replication complex GINS protein PSF1 (GINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[479]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 2 (NR1D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[77]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[683]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[684]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[139]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[685]

Drug(s) Affected By Mortality factor 4-like protein 2 (MORF4L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[604]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[686]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By Ribosome biogenesis regulatory protein homolog (RRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[98]

Drug(s) Affected By Non-POU domain-containing octamer-binding protein (NONO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[687]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[127]

Drug(s) Affected By Transcription factor E2F5 (E2F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[203]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 2 (TMED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[23]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By Poly(rC)-binding protein 2 (PCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[688]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[689]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]

Drug(s) Affected By Splicing factor 1 (SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[465]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[690]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[691]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]

Drug(s) Affected By High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]

Drug(s) Affected By Mitochondrial import receptor subunit TOM34 (TOMM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[680]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[692]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[383]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[693]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[694]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[695]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[696]

Drug(s) Affected By Retrotransposon Gag-like protein 8B (RTL8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[168]

Drug(s) Affected By Centrosome and spindle pole-associated protein 1 (CSPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Indomethacin	DMSC4A7	Bursitis		Approved	[663]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[697]

Drug(s) Affected By Atos homolog protein A (ATOSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[140]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[140]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]

Drug(s) Affected By Protein FAM161A (FAM161A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[608]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[698]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By Ceramide kinase-like protein (CERKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[699]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Prolyl endopeptidase-like (PREPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[700]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[700]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[394]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[300]
Mestranol	DMG3F94	Contraception	QA21	Approved	[394]

Drug(s) Affected By Protein FAM98B (FAM98B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By Shugoshin 2 (SGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]

Drug(s) Affected By EEF1A lysine methyltransferase 2 (EEF1AKMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Transport and Golgi organization protein 1 homolog (MIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By Alanine--tRNA ligase, mitochondrial (AARS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Heterochromatin protein 1-binding protein 3 (HP1BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[701]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[702]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15B (PPP1R15B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[703]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[704]

Drug(s) Affected By OTU domain-containing protein 3 (OTUD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Protein angel homolog 2 (ANGEL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By OTU domain-containing protein 1 (OTUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[705]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]

Drug(s) Affected By Transmembrane protein 268 (TMEM268)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Protein FAM91A1 (FAM91A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[127]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[706]

Drug(s) Affected By Male-specific lethal 1 homolog (MSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[707]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[395]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Elongator complex protein 2 (ELP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Repulsive guidance molecule B (RGMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[480]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By Rho GTPase-activating protein 11A (ARHGAP11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]

Drug(s) Affected By Embigin (EMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[699]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[438]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[699]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Glucose 1,6-bisphosphate synthase (PGM2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A9, mitochondrial (SLC30A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[362]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[125]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]

Drug(s) Affected By Progestin and adipoQ receptor family member 3 (PAQR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Arylsulfatase K (ARSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[706]

Drug(s) Affected By UPF0606 protein KIAA1549L (KIAA1549L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[708]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[709]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[85]

Drug(s) Affected By Lysophospholipid acyltransferase 2 (MBOAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[710]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[711]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[712]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By Protein FRA10AC1 (FRA10AC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[713]

Drug(s) Affected By Histone H2A.V (H2AZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[523]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[211]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[714]

Drug(s) Affected By Integrator complex subunit 8 (INTS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[223]

Drug(s) Affected By tRNA methyltransferase 10 homolog C (TRMT10C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Carbohydrate sulfotransferase 3 (CHST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Coiled-coil domain-containing protein 186 (CCDC186)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[44]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Protein MON2 homolog (MON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[621]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[165]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By Kinesin-like protein KIF21A (KIF21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]

Drug(s) Affected By tRNA-specific adenosine deaminase 2 (ADAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[715]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Ras association domain-containing protein 3 (RASSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[716]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Cytochrome c oxidase assembly factor 5 (COA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Centrosomal protein of 57 kDa (CEP57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[717]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[718]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By CDK2-associated and cullin domain-containing protein 1 (CACUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[719]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By BLOC-2 complex member HPS6 (HPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By m7GpppN-mRNA hydrolase (DCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[720]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]

Drug(s) Affected By CREB3 regulatory factor (CREBRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]

Drug(s) Affected By Epoxide hydrolase 4 (EPHX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[535]

Drug(s) Affected By Leucine rich adaptor protein 1-like (LURAP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[721]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]

Drug(s) Affected By Immunoglobulin superfamily DCC subclass member 3 (IGDCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Transmembrane protein 183A (TMEM183A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]

Drug(s) Affected By Cytoskeleton-associated protein 2-like (CKAP2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]

Drug(s) Affected By Serine/arginine repetitive matrix protein 1 (SRRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[448]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]

Drug(s) Affected By Dedicator of cytokinesis protein 3 (DOCK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Intraflagellar transport protein 70B (IFT70B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Coiled-coil domain-containing protein 82 (CCDC82)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By Translocating chain-associated membrane protein 1-like 1 (TRAM1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[162]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Transmembrane protein 156 (TMEM156)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[211]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[709]

Drug(s) Affected By Acyl-CoA-binding domain-containing protein 7 (ACBD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[229]

Drug(s) Affected By CUGBP Elav-like family member 5 (CELF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[722]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]

Drug(s) Affected By Cyclin-Y-like protein 1 (CCNYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]

Drug(s) Affected By Lysine-specific histone demethylase 2 (KDM1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF149 (RNF149)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[617]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[723]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]

Drug(s) Affected By Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[126]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Olfactory receptor 5D18 (OR5D18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[29]

Drug(s) Affected By THO complex subunit 2 (THOC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[364]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By TBC1 domain family member 15 (TBC1D15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[724]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]

Drug(s) Affected By Retinol dehydrogenase 11 (RDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Haloperidol	DM96SE0	Delirium		Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By E3 ubiquitin-protein ligase DTX3L (DTX3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[725]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By Guanine nucleotide exchange protein SMCR8 (SMCR8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By PHD finger protein 10 (PHF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[211]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[726]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By RelA-associated inhibitor (PPP1R13L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[727]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Protein Churchill (CHURC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[700]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[728]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[729]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[362]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[730]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[731]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By DEP domain-containing protein 1B (DEPDC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]

Drug(s) Affected By MIT domain-containing protein 1 (MITD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Spindle and kinetochore-associated protein 2 (SKA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By Fatty acyl-CoA reductase 1 (FAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By Gamma-secretase subunit APH-1B (APH1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By Splicing regulatory glutamine/lysine-rich protein 1 (SREK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[523]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[719]

Drug(s) Affected By Protein LZIC (LZIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[719]

Drug(s) Affected By Transcription factor AP-2-beta (TFAP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[125]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Protein FAM3C (FAM3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[431]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[211]

Drug(s) Affected By Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (GBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[732]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[733]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[734]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[735]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[736]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[737]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[738]
Mestranol	DMG3F94	Contraception	QA21	Approved	[739]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[740]

Drug(s) Affected By TATA-binding protein-associated factor 2N (TAF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]

Drug(s) Affected By Hyaluronan synthase 2 (HAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[377]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[741]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[742]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Histone acetyltransferase KAT2B (KAT2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[743]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[744]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[162]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[745]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[745]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[745]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[745]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[746]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[745]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[745]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[747]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[748]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[749]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[750]

Drug(s) Affected By GTP-binding protein Rit1 (RIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[140]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[140]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[53]

Drug(s) Affected By Nucleotide sugar transporter SLC35B4 (SLC35B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[362]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Tetratricopeptide repeat protein 17 (TTC17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Spindle and kinetochore-associated protein 1 (SKA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]

Drug(s) Affected By Primary cilium assembly protein FAM149B1 (FAM149B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]

Drug(s) Affected By Store-operated calcium entry-associated regulatory factor (SARAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[23]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By Transmembrane 4 L6 family member 18 (TM4SF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Optineurin (OPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[751]

Drug(s) Affected By Ras-related protein Rab-39B (RAB39B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[751]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[752]

Drug(s) Affected By Regulator of microtubule dynamics protein 1 (RMDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[753]

Drug(s) Affected By TBC1 domain family member 31 (TBC1D31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Protein Spindly (SPDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]

Drug(s) Affected By F-box only protein 17 (FBXO17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By THO complex subunit 1 (THOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[448]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[701]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[754]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By Distal membrane-arm assembly complex protein 1 (DMAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Transmembrane protein 19 (TMEM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[590]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[590]

Drug(s) Affected By Protein fem-1 homolog C (FEM1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Fatty acyl-CoA reductase 2 (FAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[755]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[29]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[756]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]

Drug(s) Affected By Sushi domain-containing protein 3 (SUSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]

Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[757]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[758]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[759]

Drug(s) Affected By Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By RNA-binding protein 14 (RBM14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Rab-3A-interacting protein (RAB3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Alpha-protein kinase 1 (ALPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[760]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[761]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 7 (TRPM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[762]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[763]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[764]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[58]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[765]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[58]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]

Drug(s) Affected By Structural maintenance of chromosomes protein 6 (SMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[766]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]

Drug(s) Affected By Protein IWS1 homolog (IWS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[552]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[719]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By c-Myc-binding protein (MYCBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[767]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[211]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[768]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[768]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[286]

Drug(s) Affected By M-phase phosphoprotein 6 (MPHOSPH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[598]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[769]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Protein SCAF11 (SCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[708]

Drug(s) Affected By RANBP2-like and GRIP domain-containing protein 5/6 (RGPD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[770]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Gamma-soluble NSF attachment protein (NAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[771]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[431]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[772]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[773]

Drug(s) Affected By Serine/arginine-rich splicing factor 8 (SRSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Vesicle-trafficking protein SEC22c (SEC22C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[110]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By Rho GTPase-activating protein 9 (ARHGAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[722]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[774]

Drug(s) Affected By La-related protein 6 (LARP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Mini-chromosome maintenance complex-binding protein (MCMBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]

Drug(s) Affected By Histone H2A.J (H2AJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Haloperidol	DM96SE0	Delirium		Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 10 (MED10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Nucleoporin p58/p45 (NUP58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[775]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]

Drug(s) Affected By Serine/threonine-protein kinase RIO2 (RIOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[776]

Drug(s) Affected By Fanconi anemia group J protein (BRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[334]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Actin-related protein T3 (ACTRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[595]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Voltage-gated purine nucleotide uniporter SLC17A9 (SLC17A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[777]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD3 (NSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[179]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[722]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD5 (SETD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[145]

Drug(s) Affected By DNA-dependent metalloprotease SPRTN (SPRTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[778]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By KATNB1-like protein 1 (KATNBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[212]

Drug(s) Affected By Ras-related protein Rab-33B (RAB33B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[779]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By Nonsense-mediated mRNA decay factor SMG9 (SMG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[706]

Drug(s) Affected By Kinesin-like protein KIF13A (KIF13A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[621]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By Iron-sulfur cluster assembly enzyme ISCU (ISCU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[208]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[780]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By ATP-dependent DNA/RNA helicase DHX36 (DHX36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Inorganic pyrophosphatase 2, mitochondrial (PPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]

Drug(s) Affected By Potassium voltage-gated channel subfamily F member 1 (KCNF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[731]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[731]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[778]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[505]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[781]

Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit D (TAF1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[649]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Ribosome production factor 2 homolog (RPF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By Leucine-rich repeat-containing protein 40 (LRRC40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[642]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[782]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]

Drug(s) Affected By RecQ-mediated genome instability protein 1 (RMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[235]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[783]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[638]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[639]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[522]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[641]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[588]

Drug(s) Affected By Radical S-adenosyl methionine domain-containing protein 1, mitochondrial (RSAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Histone deacetylase complex subunit SAP30L (SAP30L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[172]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 5 (PLEKHA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By E3 ubiquitin-protein ligase SMURF2 (SMURF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[93]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]

Drug(s) Affected By Otoferlin (OTOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[481]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[564]

Drug(s) Affected By Transcription and mRNA export factor ENY2 (ENY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[784]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By Protein C12orf4 (FERRY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[699]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[106]

Drug(s) Affected By E3 ubiquitin-protein ligase Jade-2 (JADE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[395]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[529]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]

Drug(s) Affected By Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[785]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[786]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By BLOC-3 complex member HPS4 (HPS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[721]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Inner centromere protein (INCENP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[680]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[681]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[82]

Drug(s) Affected By Phosphoribosyltransferase domain-containing protein 1 (PRTFDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[480]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[788]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[517]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Interleukin-17 receptor B (IL17RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]

Drug(s) Affected By Kv channel-interacting protein 2 (KCNIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[705]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Keratin, type II cuticular Hb2 (KRT82)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Ethylmalonyl-CoA decarboxylase (ECHDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[59]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[207]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]

Drug(s) Affected By FGFR1 oncogene partner 2 (FGFR1OP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]

Drug(s) Affected By Kelch-like protein 11 (KLHL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[789]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Pre-mRNA-splicing factor RBM22 (RBM22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[395]

Drug(s) Affected By Transmembrane protein 248 (TMEM248)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Calcium uniporter regulatory subunit MCUb, mitochondrial (MCUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[790]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]

Drug(s) Affected By OCIA domain-containing protein 1 (OCIAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[596]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF5 (MARCHF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[225]

Drug(s) Affected By Very long chain fatty acid elongase 2 (ELOVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Kelch-like protein 28 (KLHL28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[229]

Drug(s) Affected By CDGSH iron-sulfur domain-containing protein 1 (CISD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[699]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex assembly factor 4 (NDUFAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[791]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[536]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By COMM domain-containing protein 3 (COMMD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[139]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[195]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[140]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[452]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[172]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[140]

Drug(s) Affected By Protein NipSnap homolog 3A (NIPSNAP3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[168]

Drug(s) Affected By Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Haloperidol	DM96SE0	Delirium		Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By DNA polymerase subunit gamma-2 (POLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[681]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[792]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[590]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[202]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Prefoldin subunit 2 (PFDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[28]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[793]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[794]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[563]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[795]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[796]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[797]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[798]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[29]

Drug(s) Affected By Anaphase-promoting complex subunit 5 (ANAPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By Stomatin-like protein 2, mitochondrial (STOML2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[799]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[596]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[800]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By NTF2-related export protein 1 (NXT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[180]

Drug(s) Affected By ADP-sugar pyrophosphatase (NUDT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[478]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[193]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[166]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 6 (ACSL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[167]
Methamphetamine	DMPM4SK	Anxiety		Approved	[801]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By U3 small nucleolar RNA-associated protein NOL7 (NOL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[802]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[803]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[194]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[804]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[113]

Drug(s) Affected By DNA polymerase iota (POLI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[36]
Guanine	DMIWLJE	N. A.	N. A.	Phase 3	[805]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[114]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[806]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[544]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[82]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[807]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[69]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[808]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[808]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[100]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]

Drug(s) Affected By Nck-associated protein 1 (NCKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Bortezomib	DMNO38U	Leukemia		Approved	[53]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[647]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[119]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By Thyroid hormone receptor-associated protein 3 (THRAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[66]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[42]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[363]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]

Drug(s) Affected By RNA-binding motif protein, X-linked 2 (RBMX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By Vesicle transport protein GOT1B (GOLT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[458]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[40]

Drug(s) Affected By RNA-splicing ligase RtcB homolog (RTCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[545]

Drug(s) Affected By F-box only protein 7 (FBXO7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[127]

Drug(s) Affected By RWD domain-containing protein 3 (RWDD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[395]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[380]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[395]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[395]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[395]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By TRPM8 channel-associated factor 1 (TCAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Haloperidol	DM96SE0	Delirium		Approved	[121]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[121]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm5 (LSM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[30]

Drug(s) Affected By PAX3- and PAX7-binding protein 1 (PAXBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[37]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[31]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Drug(s) Affected By FACT complex subunit SPT16 (SUPT16H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[124]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[126]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Protocadherin alpha-3 (PCDHA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[212]

Drug(s) Affected By RNA-binding protein 8A (RBM8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[29]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[189]

Drug(s) Affected By Insulin-induced gene 2 protein (INSIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[24]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[25]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[140]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[104]

Drug(s) Affected By SEC23-interacting protein (SEC23IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[92]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5)	OTNY3VMD	PLCE_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[3]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Gene/Protein Processing	[3]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Gene/Protein Processing	[3]
Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)	OTB1FZJU	ACSA_HUMAN	Gene/Protein Processing	[3]
Actin-related protein 2/3 complex subunit 2 (ARPC2)	OTSOKOMY	ARPC2_HUMAN	Gene/Protein Processing	[3]
Actin-related protein T3 (ACTRT3)	OT2U08K8	ACTT3_HUMAN	Gene/Protein Processing	[3]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1)	OTK71JYU	TCP4_HUMAN	Gene/Protein Processing	[3]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6273).
• [2] Methyl p-hydroxybenzoate causes pain sensation through activation of TRPA1 channels. Br J Pharmacol. 2007 May;151(1):153-60.
• [3] Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
• [4] Methylparaben-induced decrease in collagen production and viability of cultured human dermal fibroblasts. J Appl Toxicol. 2017 Sep;37(9):1117-1124. doi: 10.1002/jat.3466. Epub 2017 Apr 6.
• [5] TRPV1-mediated itch in seasonal allergic rhinitis. Allergy. 2009 May;64(5):807-10.
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2023. Adis Insight
• [7] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [8] NPPB structure-specifically activates TRPA1 channels. Biochem Pharmacol. 2010 Jul 1;80(1):113-21.
• [9] Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci. 2007 Nov;26(9):2516-23.
• [10] Resolvin D1 attenuates activation of sensory transient receptor potential channels leading to multiple anti-nociception. Br J Pharmacol. 2010 Oct;161(3):707-20.
• [11] An ion channel essential for sensing chemical damage. J Neurosci. 2007 Oct 17;27(42):11412-5.
• [12] ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell. 2003 Mar 21;112(6):819-29.
• [13] Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci. 2008 Mar 5;28(10):2485-94.
• [14] TRPA1 and TRPV1 activation is a novel adjuvant effect mechanism in contact hypersensitivity. J Neuroimmunol. 2009 Feb 15;207(1-2):66-74.
• [15] Aromatase inhibition: translation into a successful therapeutic approach. Clin Cancer Res. 2005 Apr 15;11(8):2809-21. doi: 10.1158/1078-0432.CCR-04-2187.
• [16] Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling. Reprod Toxicol. 2020 Apr;93:75-82. doi: 10.1016/j.reprotox.2020.01.003. Epub 2020 Jan 14.
• [17] Effects of selective serotonin reuptake inhibitors on three sex steroids in two versions of the aromatase enzyme inhibition assay and in the H295R cell assay. Toxicol In Vitro. 2015 Oct;29(7):1729-35.
• [18] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [19] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [20] Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. J Med Chem. 2005 Mar 10;48(5):1563-75.
• [21] Comparative assessment of the inhibition of recombinant human CYP19 (aromatase) by azoles used in agriculture and as drugs for humans. Endocr Res. 2004 Aug;30(3):387-94.
• [22] Estrogen synthesis in human colon cancer epithelial cells. J Steroid Biochem Mol Biol. 1999 Dec 31;71(5-6):223-30.
• [23] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [24] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [25] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [26] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [27] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [28] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [29] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [30] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [31] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [32] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [33] Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
• [34] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [35] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [36] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [37] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [38] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [39] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [40] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [41] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [42] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [43] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [44] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [45] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [46] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [47] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [48] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [49] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [50] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [51] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [52] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [53] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [54] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [55] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [56] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [57] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [58] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [59] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [60] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [61] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [62] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [63] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [64] Targetome analysis of chaperone-mediated autophagy in cancer cells. Autophagy. 2019 Sep;15(9):1558-1571. doi: 10.1080/15548627.2019.1586255. Epub 2019 Mar 20.
• [65] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [66] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [67] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [68] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [69] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [70] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [71] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [72] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [73] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [74] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [75] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [76] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [77] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [78] Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
• [79] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [80] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [81] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [82] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [83] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [84] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [85] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [86] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [87] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [88] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [89] Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
• [90] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [91] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [92] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [93] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [94] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [95] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [96] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [97] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [98] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [99] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [100] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [101] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [102] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [103] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [104] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [105] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [106] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [107] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [108] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [109] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [110] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [111] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [112] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [113] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [114] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [115] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [116] Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
• [117] An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Jun;81:105333. doi: 10.1016/j.tiv.2022.105333. Epub 2022 Feb 16.
• [118] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [119] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [120] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [121] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [122] Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
• [123] DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
• [124] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [125] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [126] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [127] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [128] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [129] PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
• [130] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [131] Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. Clin Cancer Res. 2001 Feb;7(2):407-14.
• [132] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [133] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [134] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [135] Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
• [136] Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
• [137] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [138] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [139] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [140] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [141] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [142] DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway. Oncotarget. 2017 Aug 16;8(52):89643-89654. doi: 10.18632/oncotarget.20288. eCollection 2017 Oct 27.
• [143] Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
• [144] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [145] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [146] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [147] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [148] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [149] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [150] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [151] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [152] Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
• [153] Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
• [154] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [155] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [156] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [157] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [158] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [159] Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
• [160] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [161] Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
• [162] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [163] Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes. Drug Metab Pharmacokinet. 2004 Dec;19(6):422-9.
• [164] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [165] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [166] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [167] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [168] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [169] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [170] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [171] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [172] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [173] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [174] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [175] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [176] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [177] Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res. 2015 Jan;136:462-9. doi: 10.1016/j.envres.2014.09.040. Epub 2014 Nov 25.
• [178] Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
• [179] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [180] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [181] Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death Dis. 2019 Nov 7;10(11):846. doi: 10.1038/s41419-019-2001-7.
• [182] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [183] Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response. Am J Respir Cell Mol Biol. 2013 Dec;49(6):892-901. doi: 10.1165/rcmb.2013-0053OC.
• [184] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [185] Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Cancer Sci. 2014 May;105(5):520-7. doi: 10.1111/cas.12395. Epub 2014 Apr 11.
• [186] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [187] NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
• [188] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [189] Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiol Genomics. 2004 Jan 15;16(2):204-11.
• [190] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [191] Tumor necrosis factor-alpha induces the expression of DR6, a member of the TNF receptor family, through activation of NF-kappaB. Oncogene. 2001 Nov 29;20(55):7965-75. doi: 10.1038/sj.onc.1204985.
• [192] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [193] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [194] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [195] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [196] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [197] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [198] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [199] Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism. J Pharmacol Exp Ther. 2010 Mar;332(3):755-63.
• [200] The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man. Chem Biol Interact. 2014 Sep 5;220:241-7.
• [201] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [202] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [203] Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
• [204] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [205] Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
• [206] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [207] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [208] Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
• [209] Identification of potential protein targets of isothiocyanates by proteomics. Chem Res Toxicol. 2011 Oct 17;24(10):1735-43. doi: 10.1021/tx2002806. Epub 2011 Aug 26.
• [210] Treatment of chronic lymphocytic leukemia with a hypomethylating agent induces expression of NXF2, an immunogenic cancer testis antigen. Clin Cancer Res. 2009 May 15;15(10):3406-15. doi: 10.1158/1078-0432.CCR-08-2099. Epub 2009 Apr 28.
• [211] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [212] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [213] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [214] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [215] Time course study of A formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: protective role of autophagy. Toxicol In Vitro. 2013 Sep;27(6):1780-8. doi: 10.1016/j.tiv.2013.05.005. Epub 2013 May 29.
• [216] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [217] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [218] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [219] Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12. Autophagy. 2007 Jul-Aug;3(4):377-80. doi: 10.4161/auto.4239. Epub 2007 Jul 5.
• [220] Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother. 2019 Jan;109:2043-2053. doi: 10.1016/j.biopha.2018.11.030. Epub 2018 Nov 26.
• [221] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [222] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [223] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [224] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [225] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [226] Identification of genes targeted by the androgen and PKA signaling pathways in prostate cancer cells. Oncogene. 2006 Nov 23;25(55):7311-23.
• [227] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [228] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [229] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [230] Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology. 2007 May;28(3):478-89.
• [231] Carbon tetrachloride induced mitochondrial division, respiratory chain damage, abnormal intracellular [H(+)] and apoptosis are due to the activation of 5-HT degradation system in hepatocytes. Toxicol Appl Pharmacol. 2022 Mar 15;439:115929. doi: 10.1016/j.taap.2022.115929. Epub 2022 Feb 21.
• [232] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [233] Mechanisms of Chronic Fialuridine Hepatotoxicity as Revealed in Primary Human Hepatocyte Spheroids. Toxicol Sci. 2019 Oct 1;171(2):385-395. doi: 10.1093/toxsci/kfz195.
• [234] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [235] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [236] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [237] RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. Cancer Chemother Pharmacol. 2007 Jan;59(1):127-36. doi: 10.1007/s00280-006-0233-6. Epub 2006 Apr 14.
• [238] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [239] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [240] Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Chem Biol Interact. 2020 Jan 5;315:108865. doi: 10.1016/j.cbi.2019.108865. Epub 2019 Oct 16.
• [241] The interaction of disulfiram and H(2)S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth. Toxicol Appl Pharmacol. 2021 Sep 1;426:115642. doi: 10.1016/j.taap.2021.115642. Epub 2021 Jul 6.
• [242] Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet. 2011 Feb 11;88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007.
• [243] Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics. 2008 Aug 11;1:35. doi: 10.1186/1755-8794-1-35.
• [244] Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity. J Biochem Mol Toxicol. 2015 Mar;29(3):135-9.
• [245] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [246] Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
• [247] Small-scale immunopurification of cytochrome c oxidase for a high-throughput multiplexing analysis of enzyme activity and amount. Biotechnol Appl Biochem. 2007 Dec;48(Pt 4):167-78. doi: 10.1042/BA20060223.
• [248] Enhanced levels of several mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells. Carcinogenesis. 1998 Dec;19(12):2187-93. doi: 10.1093/carcin/19.12.2187.
• [249] An increase of cytochrome C oxidase mediated disruption of gemcitabine incorporation into DNA in a resistant KB clone. Biochem Pharmacol. 2007 Jun 15;73(12):1927-38. doi: 10.1016/j.bcp.2007.03.014. Epub 2007 Mar 20.
• [250] Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
• [251] Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
• [252] The identification of cellular targets of 17 estradiol using a lytic (T7) cDNA phage display approach. Toxicol In Vitro. 2011 Feb;25(1):388-93. doi: 10.1016/j.tiv.2010.10.012. Epub 2010 Oct 27.
• [253] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [254] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
• [255] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [256] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [257] Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
• [258] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [259] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [260] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [261] Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
• [262] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [263] Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
• [264] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [265] Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
• [266] The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb;83(2):201-11. doi: 10.2106/00004623-200102000-00007.
• [267] Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006 Apr;54(4):1298-308. doi: 10.1002/art.21723.
• [268] Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
• [269] SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress. Environ Toxicol. 2021 Jun;36(6):1070-1079. doi: 10.1002/tox.23106. Epub 2021 Feb 1.
• [270] Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol. 2001 Apr;37(5):1228-33. doi: 10.1016/s0735-1097(01)01116-0.
• [271] A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One. 2006 Dec 20;1(1):e97. doi: 10.1371/journal.pone.0000097.
• [272] Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
• [273] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [274] Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
• [275] Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. J Biol Eng. 2019 Feb 13;13:15. doi: 10.1186/s13036-019-0139-6. eCollection 2019.
• [276] Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
• [277] Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
• [278] Estrogen-like activity of metals in MCF-7 breast cancer cells. Endocrinology. 2003 Jun;144(6):2425-36. doi: 10.1210/en.2002-221054.
• [279] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [280] Bidirectional cross talk between ERalpha and EGFR signalling pathways regulates tamoxifen-resistant growth. Breast Cancer Res Treat. 2006 Mar;96(2):131-46. doi: 10.1007/s10549-005-9070-2. Epub 2005 Oct 27.
• [281] Sensitivity of human dental pulp cells to eighteen chemical agents used for endodontic treatments in dentistry. Odontology. 2013 Jan;101(1):43-51.
• [282] The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
• [283] Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
• [284] Estrogen receptor alpha mediates the proliferative but not the cytotoxic dose-dependent effects of two major phytoestrogens on human breast cancer cells. Mol Pharmacol. 2001 Sep;60(3):595-602.
• [285] Novel retinoic acid metabolism blocking agents have potent inhibitory activities on human breast cancer cells and tumour growth. Br J Cancer. 2007 Apr 23;96(8):1204-15. doi: 10.1038/sj.bjc.6603705. Epub 2007 Mar 27.
• [286] Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
• [287] In vitro blood brain barrier exposure to mycotoxins and carotenoids pumpkin extract alters mitochondrial gene expression and oxidative stress. Food Chem Toxicol. 2021 Jul;153:112261. doi: 10.1016/j.fct.2021.112261. Epub 2021 May 17.
• [288] CD34+ derived macrophage and dendritic cells display differential responses to paraquat. Toxicol In Vitro. 2021 Sep;75:105198. doi: 10.1016/j.tiv.2021.105198. Epub 2021 Jun 9.
• [289] Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
• [290] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [291] Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. doi: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h.
• [292] Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
• [293] Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
• [294] Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
• [295] Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
• [296] The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
• [297] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [298] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [299] Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
• [300] Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
• [301] Estrogenic activities of Ginkgo biloba extracts. Life Sci. 2004 Jan 30;74(11):1325-35. doi: 10.1016/j.lfs.2003.06.045.
• [302] Tartrazine and sunset yellow are xenoestrogens in a new screening assay to identify modulators of human oestrogen receptor transcriptional activity. Toxicology. 2012 Aug 16;298(1-3):40-51. doi: 10.1016/j.tox.2012.04.014. Epub 2012 May 3.
• [303] Arsenic induces functional re-expression of estrogen receptor by demethylation of DNA in estrogen receptor-negative human breast cancer. PLoS One. 2012;7(4):e35957. doi: 10.1371/journal.pone.0035957. Epub 2012 Apr 27.
• [304] Co-culture of primary human mammary fibroblasts and MCF-7 cells as an in vitro breast cancer model. Toxicol Sci. 2005 Feb;83(2):257-63.
• [305] Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
• [306] Serum distribution of the major metabolites of norgestimate in relation to its pharmacological properties. Contraception. 2003 Feb;67(2):93-9. doi: 10.1016/s0010-7824(02)00473-0.
• [307] Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene. J Clin Invest. 2007 Dec;117(12):3979-87. doi: 10.1172/JCI32249.
• [308] Reproductive effects of valproate, carbamazepine, and oxcarbazepine in men with epilepsy. Neurology. 2001 Jan 9;56(1):31-6. doi: 10.1212/wnl.56.1.31.
• [309] Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and -fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.
• [310] Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
• [311] Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
• [312] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [313] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [314] Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
• [315] Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 secretion by peripheral blood mononuclear cells in patients with primary nephrotic syndrome. Eur J Med Res. 2007 May 29;12(5):216-21.
• [316] Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
• [317] Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. doi: 10.1007/s001250050057.
• [318] Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 5;281:20-25. doi: 10.1016/j.toxlet.2017.08.012. Epub 2017 Aug 24.
• [319] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [320] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [321] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [322] The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study. Nutr J. 2005 Mar 4;4:11.
• [323] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [324] Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
• [325] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [326] Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
• [327] Conception and pharmacodynamic profile of drospirenone. Steroids. 2003 Nov;68(10-13):891-905. doi: 10.1016/j.steroids.2003.08.008.
• [328] Biological activity of all-trans-retinoic acid with and without tamoxifen and alpha-interferon 2a in breast cancer patients. Int J Oncol. 2000 Nov;17(5):991-1000. doi: 10.3892/ijo.17.5.991.
• [329] Estrogen-induced loss of progesterone receptor expression in normal and malignant ovarian surface epithelial cells. Oncogene. 2005 Jun 23;24(27):4388-400. doi: 10.1038/sj.onc.1208623.
• [330] Tibolone and its metabolites enhance tissue factor and PAI-1 expression in human endometrial stromal cells: Evidence of progestogenic effects. Steroids. 2005 Nov;70(12):840-5. doi: 10.1016/j.steroids.2005.04.010.
• [331] Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
• [332] A comparative study of the effect of raloxifene and gosereline on uterine leiomyoma volume changes and estrogen receptor, progesterone receptor, bcl-2 and p53 expression immunohistochemically in premenopausal women. Eur J Obstet Gynecol Reprod Biol. 2007 Nov;135(1):94-103. doi: 10.1016/j.ejogrb.2006.07.042. Epub 2006 Sep 14.
• [333] Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range. Toxicol In Vitro. 2006 Apr;20(3):382-94. doi: 10.1016/j.tiv.2005.08.016. Epub 2005 Oct 19.
• [334] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [335] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [336] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [337] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [338] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [339] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [340] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [341] Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400. doi: 10.1038/sj.embor.7400909. Epub 2007 Feb 23.
• [342] Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs. Arch Dermatol Res. 1993;285(7):402-9. doi: 10.1007/BF00372133.
• [343] Retinoic acid receptors as regulators of human epidermal keratinocyte differentiation. Mol Endocrinol. 1992 May;6(5):667-76. doi: 10.1210/mend.6.5.1318502.
• [344] Retinoic acid and hydroquinone induce inverse expression patterns on cornified envelope-associated proteins: implication in skin irritation. J Dermatol Sci. 2014 Nov;76(2):112-9. doi: 10.1016/j.jdermsci.2014.08.003. Epub 2014 Aug 26.
• [345] Correlation of chemopreventive efficacy data from the human epidermal cell assay with in vivo data. Anticancer Res. 2000 Jan-Feb;20(1A):27-32.
• [346] Deducing signaling pathways from parallel actions of arsenite and antimonite in human epidermal keratinocytes. Sci Rep. 2020 Feb 19;10(1):2890. doi: 10.1038/s41598-020-59577-0.
• [347] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [348] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [349] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [350] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [351] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [352] Tetracaine hydrochloride induces cell cycle arrest in melanoma by downregulating hnRNPA1. Toxicol Appl Pharmacol. 2022 Jan 1;434:115810. doi: 10.1016/j.taap.2021.115810. Epub 2021 Nov 23.
• [353] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [354] Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
• [355] Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol. 2008 May 15;75(10):1946-58. doi: 10.1016/j.bcp.2008.02.016. Epub 2008 Mar 10.
• [356] Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
• [357] Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21.
• [358] Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan;19(1):17-27. doi: 10.1007/s00775-013-1051-z. Epub 2013 Oct 17.
• [359] Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neurooncol. 1999 Jun;43(2):109-14. doi: 10.1023/a:1006202700039.
• [360] The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription. Chem Biol Interact. 2014 Aug 5;219:123-32. doi: 10.1016/j.cbi.2014.05.019. Epub 2014 Jun 4.
• [361] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [362] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [363] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [364] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [365] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [366] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [367] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [368] Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
• [369] Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
• [370] Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
• [371] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [372] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [373] Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
• [374] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [375] Genome-wide alteration in DNA hydroxymethylation in the sperm from bisphenol A-exposed men. PLoS One. 2017 Jun 5;12(6):e0178535. doi: 10.1371/journal.pone.0178535. eCollection 2017.
• [376] Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
• [377] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [378] Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
• [379] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [380] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [381] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [382] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [383] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [384] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [385] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [386] High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
• [387] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [388] Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
• [389] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [390] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [391] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [392] Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
• [393] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [394] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [395] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [396] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [397] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [398] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [399] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [400] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [401] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [402] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [403] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [404] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [405] Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
• [406] The effect of mitotane on viability, steroidogenesis and gene expression in NCI295R adrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.
• [407] The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
• [408] Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
• [409] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [410] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [411] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [412] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [413] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [414] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [415] Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
• [416] [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
• [417] Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
• [418] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [419] Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res. 2001 Oct;92(10):1133-7. doi: 10.1111/j.1349-7006.2001.tb01069.x.
• [420] HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
• [421] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [422] Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
• [423] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [424] Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
• [425] The Janus face of alcohol dehydrogenase 3. Chem Biol Interact. 2009 Mar 16;178(1-3):29-35. doi: 10.1016/j.cbi.2008.10.050. Epub 2008 Nov 6.
• [426] p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 2012 Jul;14(7):870-81. doi: 10.1093/neuonc/nos114. Epub 2012 Jun 18.
• [427] In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
• [428] JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. Eur J Pharmacol. 2007 Apr 10;560(2-3):95-100. doi: 10.1016/j.ejphar.2007.01.020. Epub 2007 Jan 19.
• [429] Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
• [430] A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
• [431] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [432] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [433] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [434] Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
• [435] Kinetic study of paracetamol on prolidase activity in erythrocytes by capillary electrophoresis with Ru(bpy)(3) (2+) electrochemiluminescence detection. Electrophoresis. 2006 Oct;27(20):4047-51. doi: 10.1002/elps.200600197.
• [436] Melanin potentiates gentamicin-induced inhibition of collagen biosynthesis in human skin fibroblasts. Eur J Pharmacol. 2002 Jun 20;446(1-3):7-13. doi: 10.1016/s0014-2999(02)01793-4.
• [437] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [438] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [439] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [440] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [441] Increased histidine decarboxylase expression during in vitro monocyte maturation; a possible role of endogenously synthesised histamine in monocyte/macrophage differentiation. Inflamm Res. 2001 Aug;50(8):428-34. doi: 10.1007/PL00000266.
• [442] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [443] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [444] Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
• [445] Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells. Cancer Sci. 2011 Aug;102(8):1582-9. doi: 10.1111/j.1349-7006.2011.01975.x. Epub 2011 Jun 23.
• [446] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [447] Toxicogenomics-based discrimination of toxic mechanism in HepG2 human hepatoma cells. Toxicol Sci. 2000 Dec;58(2):399-415.
• [448] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [449] Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
• [450] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [451] Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. doi: 10.1161/01.ATV.0000154142.61859.94. Epub 2004 Dec 23.
• [452] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [453] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [454] Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
• [455] Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
• [456] Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
• [457] Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells. Chem Biol Interact. 2023 Nov 1;385:110730. doi: 10.1016/j.cbi.2023.110730. Epub 2023 Oct 7.
• [458] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [459] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [460] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [461] Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. Cancer Biol Ther. 2010 Sep 15;10(6):632-43. doi: 10.4161/cbt.10.6.12654. Epub 2010 Sep 13.
• [462] Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
• [463] Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
• [464] Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Carcinogenesis. 2007 Mar;28(3):672-6. doi: 10.1093/carcin/bgl181. Epub 2006 Oct 17.
• [465] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [466] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [467] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [468] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [469] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [470] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [471] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [472] Considering temozolomide as a novel potential treatment for esophageal cancer. Cancer. 2011 May 1;117(9):2004-16. doi: 10.1002/cncr.25687. Epub 2010 Nov 8.
• [473] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [474] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [475] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [476] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [477] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [478] Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug;6(6):711-24. doi: 10.4161/auto.6.6.12397. Epub 2010 Aug 17.
• [479] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [480] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [481] Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol. 2007 Jan-Feb;27(1):67-77. doi: 10.1002/jat.1200.
• [482] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [483] Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene. 2001 Jan 10;262(1-2):207-14. doi: 10.1016/s0378-1119(00)00530-8.
• [484] The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
• [485] Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
• [486] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [487] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [488] Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
• [489] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [490] Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
• [491] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [492] Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
• [493] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [494] Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81. doi: 10.1016/j.yexcr.2004.02.017.
• [495] [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):74-9.
• [496] Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int J Biochem Cell Biol. 2003 Feb;35(2):246-54. doi: 10.1016/s1357-2725(02)00129-2.
• [497] Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. Int J Cancer. 2003 Dec 10;107(5):844-53. doi: 10.1002/ijc.11446.
• [498] Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
• [499] Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
• [500] Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
• [501] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [502] Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
• [503] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [504] Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere. 2017 Jan;167:454-461. doi: 10.1016/j.chemosphere.2016.10.025. Epub 2016 Oct 14.
• [505] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [506] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [507] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [508] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [509] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [510] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [511] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [512] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [513] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [514] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [515] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [516] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [517] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [518] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [519] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [520] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [521] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [522] The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
• [523] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [524] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [525] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [526] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [527] Vitamin D receptor as a master regulator of the c-MYC/MXD1 network. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32. doi: 10.1073/pnas.1210037109. Epub 2012 Oct 29.
• [528] Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State. Sci Rep. 2016 Mar 15;6:23071. doi: 10.1038/srep23071.
• [529] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [530] The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation. Biosci Rep. 2008 Jun;28(3):161-76. doi: 10.1042/BSR20080046.
• [531] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [532] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [533] Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med. 2012 May 9;18:423-32.
• [534] Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression. J Nutr Biochem. 2008 Jun;19(6):384-91.
• [535] Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
• [536] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
• [537] Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
• [538] Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
• [539] Clinical response to Nabiximols correlates with the downregulation of immune pathways in multiple sclerosis. Eur J Neurol. 2018 Jul;25(7):934-e70. doi: 10.1111/ene.13623. Epub 2018 Apr 16.
• [540] Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
• [541] Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59.
• [542] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [543] Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res. 2005 Dec 11;591(1-2):198-211.
• [544] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [545] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [546] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [547] Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions. Environ Toxicol. 2022 Aug;37(8):1831-1839. doi: 10.1002/tox.23530. Epub 2022 Apr 1.
• [548] Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017 Oct;24:147-158. doi: 10.1016/j.ebiom.2017.09.022. Epub 2017 Sep 19.
• [549] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [550] Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
• [551] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [552] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [553] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [554] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [555] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [556] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [557] Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs. Int J Cardiol. 2010 Apr 1;140(1):73-81. doi: 10.1016/j.ijcard.2008.11.017. Epub 2008 Dec 6.
• [558] [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jan;28(1):12-6.
• [559] Leptin production in adipocytes from morbidly obese subjects: stimulation by dexamethasone, inhibition with troglitazone, and influence of gender. J Clin Endocrinol Metab. 2000 Aug;85(8):2678-84. doi: 10.1210/jcem.85.8.6733.
• [560] Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
• [561] The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
• [562] Amlodipine improves endothelial function and metabolic parameters in patients with hypertension. Int J Cardiol. 2009 Mar 20;133(1):23-31. doi: 10.1016/j.ijcard.2007.11.058. Epub 2008 Jan 15.
• [563] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [564] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [565] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [566] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [567] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [568] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [569] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [570] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [571] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [572] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [573] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [574] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [575] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [576] Arsenic trioxide inhibits P-glycoprotein expression in multidrug-resistant human leukemia K562/ADM cell line that overexpresses mdr-1 gene and enhances their chemotherapeutic sensitivity. Zhonghua Xue Ye Xue Za Zhi. 2003 Jan;24(1):28-31.
• [577] Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
• [578] Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
• [579] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [580] Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood. Exp Hematol. 2006 Apr;34(4):453-62. doi: 10.1016/j.exphem.2006.01.003.
• [581] Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis. Gynecol Endocrinol. 2005 Mar;20(3):127-31. doi: 10.1080/09513590400021086.
• [582] Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
• [583] Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
• [584] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [585] Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
• [586] Apigenin Inhibits Cancer Stem Cell-Like Phenotypes in Human Glioblastoma Cells via Suppression of c-Met Signaling. Phytother Res. 2016 Nov;30(11):1833-1840. doi: 10.1002/ptr.5689. Epub 2016 Jul 29.
• [587] Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres. Acta Neuropathol Commun. 2014 Mar 31;2:31. doi: 10.1186/2051-5960-2-31.
• [588] Ivermectin as an inhibitor of cancer stem?like cells. Mol Med Rep. 2018 Feb;17(2):3397-3403. doi: 10.3892/mmr.2017.8231. Epub 2017 Dec 8.
• [589] Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.
• [590] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [591] Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
• [592] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [593] Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst. 2010 Dec 15;102(24):1855-73. doi: 10.1093/jnci/djq457. Epub 2010 Nov 18.
• [594] Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
• [595] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [596] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [597] Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
• [598] Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
• [599] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [600] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [601] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [602] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [603] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [604] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [605] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [606] Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir Res. 2005 Aug 8;6(1):89. doi: 10.1186/1465-9921-6-89.
• [607] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [608] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [609] BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52.
• [610] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [611] Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells. Neurosignals. 2011;19(2):97-109. doi: 10.1159/000326342. Epub 2011 Apr 10.
• [612] A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults. Cancer. 1995 Dec 15;76(12):2557-64. doi: 10.1002/1097-0142(19951215)76:12<2557::aid-cncr2820761223>3.0.co;2-9.
• [613] Serum clara-cell protein and beta2-microglobulin as early markers of occupational exposure to nitric oxides. Inhal Toxicol. 2005 Feb;17(2):87-97. doi: 10.1080/08958370590899460.
• [614] Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients. Miner Electrolyte Metab. 1996;22(4):219-23.
• [615] Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int. 2001 May;68(5):285-90.
• [616] High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
• [617] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [618] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [619] Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005 Sep;130(6):912-25. doi: 10.1111/j.1365-2141.2005.05696.x.
• [620] Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer. 2008 May 1;122(9):2115-24. doi: 10.1002/ijc.23315.
• [621] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [622] 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
• [623] Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach. BMC Genomics. 2006 Sep 29;7:246. doi: 10.1186/1471-2164-7-246.
• [624] Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. Biol Pharm Bull. 2010;33(5):743-51. doi: 10.1248/bpb.33.743.
• [625] Gene expression signature of parathion-transformed human breast epithelial cells. Int J Mol Med. 2007 May;19(5):741-50.
• [626] Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25. doi: 10.1016/j.bbrc.2004.04.108.
• [627] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [628] Inhibition of TGF-/SMAD3/NF-B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2014 Nov 18;231(1):55-61. doi: 10.1016/j.toxlet.2014.08.024. Epub 2014 Sep 6.
• [629] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [630] Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
• [631] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [632] Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
• [633] Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
• [634] Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
• [635] Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells. Cancer Res. 2004 Nov 15;64(22):8167-76. doi: 10.1158/0008-5472.CAN-04-0970.
• [636] Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
• [637] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [638] Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
• [639] Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
• [640] Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
• [641] Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
• [642] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [643] Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
• [644] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [645] Overexpression of protein kinase C-beta1 isoenzyme suppresses indomethacin-induced apoptosis in gastric epithelial cells. Gastroenterology. 2000 Mar;118(3):507-14. doi: 10.1016/s0016-5085(00)70256-3.
• [646] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [647] Factors determining sensitivity or resistance of tumor cell lines towards artesunate. Chem Biol Interact. 2010 Apr 15;185(1):42-52.
• [648] Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
• [649] Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population. Cancer Epidemiol Biomarkers Prev. 2006 Jul;15(7):1367-75. doi: 10.1158/1055-9965.EPI-06-0106.
• [650] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [651] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [652] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [653] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [654] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [655] Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
• [656] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [657] The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
• [658] Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
• [659] Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
• [660] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [661] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [662] Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. PLoS One. 2013 Dec 3;8(12):e82086. doi: 10.1371/journal.pone.0082086. eCollection 2013.
• [663] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [664] Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
• [665] Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15676-81. doi: 10.1073/pnas.0405155101. Epub 2004 Oct 21.
• [666] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [667] Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
• [668] PP2A-B56? complex is involved in dephosphorylation of -H2AX in the repair process of CPT-induced DNA double-strand breaks. Toxicology. 2015 May 4;331:57-65. doi: 10.1016/j.tox.2015.03.007. Epub 2015 Mar 12.
• [669] Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
• [670] The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
• [671] Targeting of EGFR increase?anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform. Eur J Pharmacol. 2018 Feb 5;820:274-285. doi: 10.1016/j.ejphar.2017.12.041. Epub 2017 Dec 20.
• [672] Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
• [673] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [674] An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. doi: 10.1074/jbc.M702454200. Epub 2007 Oct 31.
• [675] Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. J Pharmacol Exp Ther. 2005 Aug;314(2):846-54. doi: 10.1124/jpet.105.083519. Epub 2005 May 18.
• [676] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [677] 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
• [678] Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
• [679] Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation. J Biol Chem. 2019 Feb 15;294(7):2436-2448. doi: 10.1074/jbc.RA118.005069. Epub 2018 Dec 13.
• [680] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [681] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [682] Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
• [683] System analysis of cross-talk between nuclear receptors reveals an opposite regulation of the cell cycle by LXR and FXR in human HepaRG liver cells. PLoS One. 2019 Aug 22;14(8):e0220894. doi: 10.1371/journal.pone.0220894. eCollection 2019.
• [684] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [685] Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
• [686] Single-cell transcription site activation predicts chemotherapy response in human colorectal tumors. Cancer Res. 2008 Jul 1;68(13):4977-82. doi: 10.1158/0008-5472.CAN-07-6770.
• [687] Mechanisms of the growth inhibitory effects of the isoflavonoid biochanin A on LNCaP cells and xenografts. Prostate. 2002 Aug 1;52(3):201-12.
• [688] Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Biochem J. 2011 Sep 1;438(2):349-58. doi: 10.1042/BJ20101653.
• [689] Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells. Am J Pathol. 2005 Oct;167(4):947-57. doi: 10.1016/S0002-9440(10)61185-6.
• [690] Intergenerational genetic programming mechanism and sex differences of the adrenal corticosterone synthesis dysfunction in offspring induced by prenatal ethanol exposure. Toxicol Lett. 2021 Oct 15;351:78-88. doi: 10.1016/j.toxlet.2021.08.007. Epub 2021 Aug 25.
• [691] Androgen receptor modulation following combination exposure to brominated flame-retardants. Sci Rep. 2018 Mar 19;8(1):4843. doi: 10.1038/s41598-018-23181-0.
• [692] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [693] Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
• [694] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [695] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [696] P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
• [697] Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One. 2011;6(7):e21920. doi: 10.1371/journal.pone.0021920. Epub 2011 Jul 6.
• [698] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [699] Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
• [700] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [701] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [702] BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec;92(6):1147-54. doi: 10.1189/jlb.0312165. Epub 2012 Jul 16.
• [703] A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
• [704] Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2730-5. doi: 10.1073/pnas.1018872108. Epub 2011 Apr 11.
• [705] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [706] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [707] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [708] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [709] PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
• [710] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [711] A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system. Toxicol Lett. 2014 Nov 18;231(1):38-44.
• [712] Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
• [713] Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett. 2006 Mar 20;580(7):1733-9.
• [714] ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
• [715] BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17.
• [716] Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
• [717] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [718] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [719] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [720] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [721] Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
• [722] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [723] Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet. 2007 Nov;3(11):e207.
• [724] Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
• [725] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [726] Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
• [727] Expression of the RAI gene is conducive to apoptosis: studies of induction and interference. Exp Cell Res. 2007 Jul 15;313(12):2611-21. doi: 10.1016/j.yexcr.2007.05.006. Epub 2007 May 22.
• [728] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [729] High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLoS One. 2013;8(1):e53393. doi: 10.1371/journal.pone.0053393. Epub 2013 Jan 4.
• [730] Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
• [731] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [732] Combined tamoxifen and gefitinib in non-small cell lung cancer shows antiproliferative effects. Biomed Pharmacother. 2010 Feb;64(2):88-92. doi: 10.1016/j.biopha.2009.06.010. Epub 2009 Oct 23.
• [733] Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Environ Toxicol. 2020 Nov;35(11):1179-1193. doi: 10.1002/tox.22983. Epub 2020 Jun 12.
• [734] Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology. 2001 Sep 14;166(1-2):79-89. doi: 10.1016/s0300-483x(01)00437-1.
• [735] Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen alpha and beta receptors. FASEB J. 2006 Jul;20(9):1552-4. doi: 10.1096/fj.05-5413fje. Epub 2006 May 23.
• [736] Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications. Toxicol Lett. 2010 Feb 15;192(3):298-315. doi: 10.1016/j.toxlet.2009.11.004. Epub 2009 Nov 12.
• [737] Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
• [738] Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.
• [739] Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul;66(7):1479-87. doi: 10.1271/bbb.66.1479.
• [740] Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies. J Med Chem. 2011 Jan 13;54(1):302-11. doi: 10.1021/jm101163m. Epub 2010 Dec 3.
• [741] Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010 Jan;130(1):141-9. doi: 10.1038/jid.2009.210.
• [742] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [743] Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
• [744] Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
• [745] Examining the genomic influence of skin antioxidants in vitro. Mediators Inflamm. 2010;2010.
• [746] Contact allergen (PPD and DNCB)-induced keratinocyte sensitization is partly mediated through a low molecular weight hyaluronan (LMWHA)/TLR4/NF-B signaling axis. Toxicol Appl Pharmacol. 2019 Aug 15;377:114632. doi: 10.1016/j.taap.2019.114632. Epub 2019 Jun 19.
• [747] Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth. J Cell Biochem. 2005 Nov 1;96(4):760-74. doi: 10.1002/jcb.20474.
• [748] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [749] Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
• [750] Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
• [751] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [752] The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
• [753] Labeling and identification of LNCaP cell surface proteins: a pilot study. Prostate. 2007 Jun 15;67(9):943-54. doi: 10.1002/pros.20580.
• [754] Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro. Cell Biol Toxicol. 2023 Feb;39(1):319-343. doi: 10.1007/s10565-022-09730-4. Epub 2022 Jun 15.
• [755] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [756] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [757] Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5. Toxicol Appl Pharmacol. 2022 Jan 15;435:115829. doi: 10.1016/j.taap.2021.115829. Epub 2021 Dec 14.
• [758] Histone arginine methylation in cocaine action in the nucleus accumbens. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.
• [759] Berberine acts as a putative epigenetic modulator by affecting the histone code. Toxicol In Vitro. 2016 Oct;36:10-17. doi: 10.1016/j.tiv.2016.06.004. Epub 2016 Jun 13.
• [760] Enhanced alpha-kinase 1 accelerates multiple early nephropathies in streptozotocin-induced hyperglycemic mice. Biochim Biophys Acta. 2016 Nov;1862(11):2034-2042. doi: 10.1016/j.bbadis.2016.08.010. Epub 2016 Aug 16.
• [761] Genome-wide association study of epirubicin-induced leukopenia in Japanese patients. Pharmacogenet Genomics. 2011 Sep;21(9):552-8. doi: 10.1097/FPC.0b013e328348e48f.
• [762] Quercetin induces apoptosis by inhibiting MAPKs and TRPM7 channels in AGS cells. Int J Mol Med. 2014 Jun;33(6):1657-63. doi: 10.3892/ijmm.2014.1704. Epub 2014 Mar 18.
• [763] TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival. Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4706-4715. doi: 10.1073/pnas.1810633116. Epub 2019 Feb 15.
• [764] Role of TRPM7 channels in hyperglycemia-mediated injury of vascular endothelial cells. PLoS One. 2013 Nov 1;8(11):e79540.
• [765] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [766] Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression. PLoS One. 2009;4(2):e4409.
• [767] Transforming growth factor beta1 targets estrogen receptor signaling in bronchial epithelial cells. Respir Res. 2018 Aug 30;19(1):160. doi: 10.1186/s12931-018-0861-5.
• [768] Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
• [769] Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. doi: 10.1165/rcmb.2008-0012OC. Epub 2008 Apr 17.
• [770] High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity. Nucleic Acids Res. 2015 Mar 11;43(5):2525-34. doi: 10.1093/nar/gkv115. Epub 2015 Feb 17.
• [771] Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
• [772] Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
• [773] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [774] Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not. Am J Clin Nutr. 2007 Jul;86(1):230-9. doi: 10.1093/ajcn/86.1.230.
• [775] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [776] Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
• [777] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [778] Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
• [779] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [780] Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2015 Feb 3;328:102-11. doi: 10.1016/j.tox.2014.12.018. Epub 2014 Dec 18.
• [781] Hepatic cells derived from human skin progenitors show a typical phospholipidotic response upon exposure to amiodarone. Toxicol Lett. 2018 Mar 1;284:184-194. doi: 10.1016/j.toxlet.2017.11.014. Epub 2017 Dec 15.
• [782] Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
• [783] Methylparaben stimulates tumor initiating cells in ER+ breast cancer models. J Appl Toxicol. 2017 Apr;37(4):417-425. doi: 10.1002/jat.3374. Epub 2016 Sep 1.
• [784] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [785] Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.
• [786] Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing. Mutat Res. 2010 Apr 1;686(1-2):47-56. doi: 10.1016/j.mrfmmm.2010.01.015. Epub 2010 Jan 25.
• [787] Transcriptional Regulation of Human Arylamine N-Acetyltransferase 2 Gene by Glucose and Insulin in Liver Cancer Cell Lines. Toxicol Sci. 2022 Nov 23;190(2):158-172. doi: 10.1093/toxsci/kfac103.
• [788] PRTFDC1, a possible tumor-suppressor gene, is frequently silenced in oral squamous-cell carcinomas by aberrant promoter hypermethylation. Oncogene. 2007 Dec 13;26(57):7921-32. doi: 10.1038/sj.onc.1210589. Epub 2007 Jun 18.
• [789] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [790] Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
• [791] New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
• [792] Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
• [793] Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
• [794] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [795] Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 2007 Feb 2;412(3):211-6. doi: 10.1016/j.neulet.2006.07.045. Epub 2007 Jan 17.
• [796] Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
• [797] Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
• [798] Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009 Apr 3;1:25-37.
• [799] Poly(ADP-ribose) glycohydrolase silencing down-regulates TCTP and Cofilin-1 associated with metastasis in benzo(a)pyrene carcinogenesis. Am J Cancer Res. 2014 Dec 15;5(1):155-67. eCollection 2015.
• [800] ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
• [801] Genome-wide association for methamphetamine dependence: convergent results from 2 samples. Arch Gen Psychiatry. 2008 Mar;65(3):345-55. doi: 10.1001/archpsyc.65.3.345.
• [802] Association of Glyphosate Exposure with Blood DNA Methylation in a Cross-Sectional Study of Postmenopausal Women. Environ Health Perspect. 2022 Apr;130(4):47001. doi: 10.1289/EHP10174. Epub 2022 Apr 4.
• [803] Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicol In Vitro. 2015 Aug;29(5):1060-9.
• [804] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [805] Analysis of nucleotide insertion opposite 2,2,4-triamino-5(2H)-oxazolone by eukaryotic B- and Y-family DNA polymerases. Chem Res Toxicol. 2015 Jun 15;28(6):1307-16. doi: 10.1021/acs.chemrestox.5b00114. Epub 2015 Jun 3.
• [806] Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18;26(2):221-32. doi: 10.1021/tx300392m. Epub 2013 Jan 31.
• [807] Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
• [808] Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.