Details of the Drug Combination

General Information of Drug Combination (ID: DC9NQ49)

• Drug Combination Name: Cyclophosphamide + Dasatinib
• Indication: Ewing sarcoma-peripheral primitive neuroectodermal tumour; Status: Investigative [1]
• Component Drugs:
  Cyclophosphamide (DM4O2Z7): Small molecular drug
  Dasatinib (DMJV2EK): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: ES2
  Zero Interaction Potency (ZIP) Score: 5.41
  Bliss Independence Score: 9.53
  Loewe Additivity Score: 1.52
  LHighest Single Agent (HSA) Score: 5.16

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Cyclophosphamide

Disease Entry	ICD 11	Status	REF
Advanced cancer	2A00-2F9Z	Approved	[2]
Central nervous system neoplasm	N.A.	Approved	[2]
Glioblastoma	2A00	Approved	[2]
Immunodeficiency	4A00-4A85	Approved	[2]
Inflammatory breast cancer	2C62	Approved	[2]
Lupus nephritis	4A40.0Y	Approved	[2]
Lymphoma	2A80-2A86	Approved	[2]
Multiple sclerosis	8A40	Approved	[2]
Mycosis fungoides	2B01	Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[3]
Classic Hodgkin lymphoma	N.A.	Investigative	[2]
Neuroblastoma	2D11.2	Investigative	[2]
Retinoblastoma	2D02.2	Investigative	[2]
Scleroderma	4A42	Investigative	[2]

Cyclophosphamide Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Human Deoxyribonucleic acid (hDNA)	TTUTN1I	NOUNIPROTAC	Modulator	[14]

Cyclophosphamide Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[15]

Cyclophosphamide Interacts with 8 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[16]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[17]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[18]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Metabolism	[17]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[19]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[20]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[21]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[22]

Cyclophosphamide Interacts with 225 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Increases Activity	[23]
Cytochrome P450 2C18 (CYP2C18)	OTY687L9	CP2CI_HUMAN	Increases Activity	[23]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[24]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Increases Hydroxylation	[25]
Glucose-6-phosphate 1-dehydrogenase (G6PD)	OT300SMK	G6PD_HUMAN	Increases ADR	[8]
Cytochrome P450 2D6 (CYP2D6)	OTZJC802	CP2D6_HUMAN	Increases Metabolism	[26]
Cholinesterase (BCHE)	OTOH3WQ9	CHLE_HUMAN	Decreases Activity	[27]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[28]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[28]
Band 4.1-like protein 2 (EPB41L2)	OT6UABPM	E41L2_HUMAN	Decreases Expression	[29]
Receptor activity-modifying protein 1 (RAMP1)	OT7UT2XB	RAMP1_HUMAN	Increases Expression	[29]
Cystatin-F (CST7)	OTQWZUVQ	CYTF_HUMAN	Decreases Expression	[29]
Kelch repeat and BTB domain-containing protein 11 (KBTBD11)	OTBOY3WH	KBTBB_HUMAN	Decreases Expression	[29]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Increases Expression	[29]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Decreases Expression	[29]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[29]
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Increases Expression	[29]
Procathepsin L (CTSL)	OTYTUW29	CATL1_HUMAN	Increases Expression	[29]
Galectin-1 (LGALS1)	OT8LDFWR	LEG1_HUMAN	Increases Expression	[29]
SPARC (SPARC)	OTPN90H0	SPRC_HUMAN	Increases Expression	[29]
Pro-cathepsin H (CTSH)	OTLFL0DG	CATH_HUMAN	Increases Expression	[29]
Non-secretory ribonuclease (RNASE2)	OT8Z4FNE	RNAS2_HUMAN	Decreases Expression	[29]
Transcriptional regulator ERG (ERG)	OTOTX9VU	ERG_HUMAN	Increases Expression	[29]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[29]
Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)	OTVT146E	CX7A2_HUMAN	Decreases Expression	[29]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[29]
Bactericidal permeability-increasing protein (BPI)	OTNN9LJ5	BPI_HUMAN	Decreases Expression	[29]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)	OT0DH40W	AL5AP_HUMAN	Decreases Expression	[29]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Decreases Expression	[29]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Increases Expression	[29]
Myeloblastin (PRTN3)	OT72MHP7	PRTN3_HUMAN	Decreases Expression	[29]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Decreases Expression	[29]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Decreases Expression	[29]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Increases Expression	[29]
Transmembrane 4 L6 family member 1 (TM4SF1)	OTY0ECQN	T4S1_HUMAN	Increases Expression	[29]
Intercellular adhesion molecule 3 (ICAM3)	OTTZ5A5D	ICAM3_HUMAN	Decreases Expression	[29]
P2Y purinoceptor 2 (P2RY2)	OT47XN46	P2RY2_HUMAN	Decreases Expression	[29]
Glycine receptor subunit beta (GLRB)	OTF37UG4	GLRB_HUMAN	Increases Expression	[29]
C-C chemokine receptor type 8 (CCR8)	OTSCMH06	CCR8_HUMAN	Decreases Expression	[29]
Ras-related protein R-Ras2 (RRAS2)	OT83NCEB	RRAS2_HUMAN	Increases Expression	[29]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Decreases Expression	[29]
Angiopoietin-1 (ANGPT1)	OTVZ1NG3	ANGP1_HUMAN	Increases Expression	[29]
Fascin (FSCN1)	OTTGIHTM	FSCN1_HUMAN	Increases Expression	[29]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[29]
Testis-expressed protein 30 (TEX30)	OT87WEPQ	TEX30_HUMAN	Decreases Expression	[29]
Ras-related GTP-binding protein A (RRAGA)	OTKISLG4	RRAGA_HUMAN	Decreases Expression	[29]
Cilium assembly protein DZIP1 (DZIP1)	OTBVPO66	DZIP1_HUMAN	Increases Expression	[29]
RNA-binding protein with multiple splicing (RBPMS)	OT1RDKR9	RBPMS_HUMAN	Increases Expression	[29]
Membrane-spanning 4-domains subfamily A member 3 (MS4A3)	OT0CEJOO	MS4A3_HUMAN	Decreases Expression	[29]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Increases Expression	[29]
MyoD family inhibitor domain-containing protein (MDFIC)	OTSRYBWZ	MDFIC_HUMAN	Decreases Expression	[29]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12)	OTOGF42G	GBG12_HUMAN	Increases Expression	[29]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5)	OT03QCLM	ATF5_HUMAN	Decreases Expression	[29]
PALM2-AKAP2 fusion protein (PALM2AKAP2)	OTI618VF	PLAK2_HUMAN	Increases Expression	[29]
Dihydropyrimidinase-related protein 4 (DPYSL4)	OT3SBS2S	DPYL4_HUMAN	Increases Expression	[9]
Integral membrane protein GPR137B (GPR137B)	OT1CINQQ	G137B_HUMAN	Increases Expression	[9]
Glutaminase kidney isoform, mitochondrial (GLS)	OTGOZG2M	GLSK_HUMAN	Increases Expression	[9]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[9]
Ubiquitin-like protein ISG15 (ISG15)	OT53QQ7N	ISG15_HUMAN	Increases Expression	[9]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[9]
Stomatin (STOM)	OTC8R6EH	STOM_HUMAN	Increases Expression	[9]
Cellular retinoic acid-binding protein 2 (CRABP2)	OTY01V9G	RABP2_HUMAN	Increases Expression	[9]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Increases Expression	[9]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Expression	[9]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[9]
Tumor necrosis factor ligand superfamily member 9 (TNFSF9)	OTV9L89D	TNFL9_HUMAN	Increases Expression	[9]
Galectin-7 (LGALS7)	OTMSVI7R	LEG7_HUMAN	Increases Expression	[9]
Rho GDP-dissociation inhibitor 2 (ARHGDIB)	OT9PD6CS	GDIR2_HUMAN	Increases Expression	[9]
Epithelial membrane protein 1 (EMP1)	OTSZHUHQ	EMP1_HUMAN	Increases Expression	[9]
Epithelial membrane protein 3 (EMP3)	OTODMJ1D	EMP3_HUMAN	Increases Expression	[9]
Protein ripply3 (RIPPLY3)	OT1HK35I	DSCR6_HUMAN	Increases Expression	[9]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Expression	[9]
Antigen peptide transporter 1 (TAP1)	OTJL27PW	TAP1_HUMAN	Increases Expression	[9]
Laminin subunit gamma-2 (LAMC2)	OTJMTM72	LAMC2_HUMAN	Increases Expression	[9]
Filamin-C (FLNC)	OT3F8J6Y	FLNC_HUMAN	Increases Expression	[9]
Immediate early response gene 5 protein (IER5)	OTJPTXMD	IER5_HUMAN	Increases Expression	[9]
Keratin, type II cytoskeletal 80 (KRT80)	OTAU54U3	K2C80_HUMAN	Increases Expression	[9]
Neuropilin and tolloid-like protein 2 (NETO2)	OT0YAMC0	NETO2_HUMAN	Increases Expression	[9]
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2)	OTOF6O2B	B3GL2_HUMAN	Increases Expression	[9]
Phospholipase ABHD3 (ABHD3)	OTH8P977	ABHD3_HUMAN	Increases Expression	[9]
Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)	OTB82PFO	TNR14_HUMAN	Increases Expression	[9]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Increases Expression	[9]
Tumor necrosis factor receptor superfamily member 27 (EDA2R)	OTJLAIIH	TNR27_HUMAN	Increases Expression	[9]
Stathmin-3 (STMN3)	OT20F289	STMN3_HUMAN	Increases Expression	[9]
Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)	OTVUZCLG	GTR6_HUMAN	Increases Expression	[9]
Endothelial protein C receptor (PROCR)	OTRHED17	EPCR_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Decreases Expression	[10]
Interferon-related developmental regulator 1 (IFRD1)	OT4SQMLQ	IFRD1_HUMAN	Decreases Expression	[10]
Kinesin-like protein KIF21B (KIF21B)	OTFXFIU3	KI21B_HUMAN	Decreases Expression	[10]
Large neutral amino acids transporter small subunit 3 (SLC43A1)	OTQJQY3S	LAT3_HUMAN	Decreases Expression	[10]
Cystatin-A (CSTA)	OT1K68KE	CYTA_HUMAN	Decreases Expression	[10]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Decreases Expression	[10]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Decreases Expression	[10]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[10]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Decreases Expression	[10]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Decreases Expression	[10]
Protein EVI2A (EVI2A)	OTR8RUXQ	EVI2A_HUMAN	Decreases Expression	[10]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Decreases Expression	[10]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[10]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Decreases Expression	[10]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Decreases Expression	[10]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Decreases Expression	[10]
Cysteine--tRNA ligase, cytoplasmic (CARS1)	OTOUZF6O	SYCC_HUMAN	Decreases Expression	[10]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Decreases Expression	[10]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Expression	[10]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Decreases Expression	[10]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Decreases Expression	[10]
Transmembrane protein 267 (TMEM267)	OTEAAVK7	TM267_HUMAN	Decreases Expression	[10]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Decreases Expression	[10]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Increases Expression	[10]
N-arachidonyl glycine receptor (GPR18)	OTL2VFIV	GPR18_HUMAN	Decreases Expression	[10]
Nuclear receptor coactivator 7 (NCOA7)	OT2CNBOG	NCOA7_HUMAN	Decreases Expression	[10]
Alanine aminotransferase 2 (GPT2)	OTS5VF7N	ALAT2_HUMAN	Decreases Expression	[10]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Increases Expression	[10]
Heat shock protein 105 kDa (HSPH1)	OTVRR73T	HS105_HUMAN	Increases Expression	[10]
Insulin gene enhancer protein ISL-2 (ISL2)	OT43PD2V	ISL2_HUMAN	Decreases Expression	[10]
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)	OTMLBCLC	PELI1_HUMAN	Decreases Expression	[10]
Centriolar and ciliogenesis-associated protein HYLS1 (HYLS1)	OT3SW5UC	HYLS1_HUMAN	Decreases Expression	[10]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Decreases Expression	[10]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Decreases Expression	[10]
Transmembrane 6 superfamily member 1 (TM6SF1)	OTQR4I2N	TM6S1_HUMAN	Decreases Expression	[10]
Protein FAM107B (FAM107B)	OT5RG4J0	F107B_HUMAN	Decreases Expression	[10]
Lysine-rich coiled-coil protein 1 (KRCC1)	OTMMV6WZ	KRCC1_HUMAN	Decreases Expression	[10]
DnaJ homolog subfamily B member 4 (DNAJB4)	OTUD01BK	DNJB4_HUMAN	Increases Expression	[10]
SLAM family member 5 (CD84)	OTAY5B0F	SLAF5_HUMAN	Increases Expression	[10]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Decreases Expression	[10]
Nuclear factor erythroid 2-related factor 3 (NFE2L3)	OT1MGXT0	NF2L3_HUMAN	Decreases Expression	[10]
Dual specificity protein phosphatase 10 (DUSP10)	OTNG467B	DUS10_HUMAN	Decreases Expression	[10]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Decreases Expression	[11]
Transmembrane protease serine 2 (TMPRSS2)	OTN44YQ5	TMPS2_HUMAN	Increases Expression	[30]
Growth arrest-specific protein 2 (GAS2)	OT50JKXQ	GAS2_HUMAN	Increases Expression	[31]
Lysine-specific histone demethylase 1A (KDM1A)	OT85JXS5	KDM1A_HUMAN	Increases Expression	[32]
Slit homolog 1 protein (SLIT1)	OT35RBNT	SLIT1_HUMAN	Decreases Expression	[12]
DnaJ homolog subfamily B member 6 (DNAJB6)	OTMHIIAN	DNJB6_HUMAN	Increases Expression	[31]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[33]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Increases Expression	[34]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Increases Mutagenesis	[35]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Mutagenesis	[36]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Increases Expression	[37]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[33]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Decreases Expression	[38]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[39]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Increases Expression	[40]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[41]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Increases Expression	[42]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Phosphorylation	[43]
Natriuretic peptides B (NPPB)	OTSN2IPY	ANFB_HUMAN	Increases Expression	[37]
Troponin I, cardiac muscle (TNNI3)	OT65E12V	TNNI3_HUMAN	Increases Expression	[37]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[44]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[11]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[12]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[12]
DNA cytosine-5)-methyltransferase 1 (DNMT1)	OTM2DGTK	DNMT1_HUMAN	Decreases Methylation	[32]
Proteasome subunit alpha type-5 (PSMA5)	OT38E6Y1	PSA5_HUMAN	Increases Expression	[31]
HLA class I histocompatibility antigen, alpha chain F (HLA-F)	OT76CM19	HLAF_HUMAN	Increases Expression	[12]
Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)	OTRAFFX2	GPX4_HUMAN	Increases Expression	[31]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Expression	[42]
Cytosolic purine 5'-nucleotidase (NT5C2)	OTJMF66Z	5NTC_HUMAN	Increases Expression	[12]
Tumor protein D52 (TPD52)	OTPKSK43	TPD52_HUMAN	Decreases Expression	[44]
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)	OT29B58J	KCNQ4_HUMAN	Decreases Expression	[12]
Heterogeneous nuclear ribonucleoprotein K (HNRNPK)	OTNPRM8U	HNRPK_HUMAN	Increases Expression	[31]
Protein BTG2 (BTG2)	OTZF6K1H	BTG2_HUMAN	Increases Expression	[11]
Runt-related transcription factor 3 (RUNX3)	OTITK1XD	RUNX3_HUMAN	Decreases Expression	[12]
Calicin (CCIN)	OTRFZOT0	CALI_HUMAN	Increases Expression	[31]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Decreases Expression	[44]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)	OTE8GBUR	RIR2B_HUMAN	Increases Expression	[45]
Partitioning defective 3 homolog (PARD3)	OTH5BPLO	PARD3_HUMAN	Decreases Expression	[12]
GATOR1 complex protein NPRL2 (NPRL2)	OTOB10MO	NPRL2_HUMAN	Decreases Expression	[12]
F-box/WD repeat-containing protein 7 (FBXW7)	OTJXE4OT	FBXW7_HUMAN	Increases Expression	[11]
Rho guanine nucleotide exchange factor 26 (ARHGEF26)	OTX0U8PX	ARHGQ_HUMAN	Increases Expression	[12]
G-protein coupled receptor 20 (GPR20)	OTPCR8F7	GPR20_HUMAN	Increases Expression	[12]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Decreases Expression	[30]
Polyadenylate-binding protein-interacting protein 1 (PAIP1)	OTL2F5T5	PAIP1_HUMAN	Decreases Expression	[12]
Large subunit GTPase 1 homolog (LSG1)	OTDAXJ9L	LSG1_HUMAN	Decreases Expression	[12]
Glyoxalase domain-containing protein 4 (GLOD4)	OTBJKFXA	GLOD4_HUMAN	Decreases Expression	[12]
DNA-directed DNA/RNA polymerase mu (POLM)	OT0SRIP4	DPOLM_HUMAN	Increases Expression	[12]
Ubiquitin-like-conjugating enzyme ATG3 (ATG3)	OT28VBVK	ATG3_HUMAN	Decreases Expression	[12]
Regulator of telomere elongation helicase 1 (RTEL1)	OTI3PJCT	RTEL1_HUMAN	Increases Expression	[31]
FK506-binding protein-like (FKBPL)	OTR9ND6K	FKBPL_HUMAN	Increases Expression	[42]
Mitochondrial pyruvate carrier 2 (MPC2)	OT0GHXGG	MPC2_HUMAN	Affects Response To Substance	[13]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Affects Response To Substance	[13]
Galactocerebrosidase (GALC)	OT1F6BZK	GALC_HUMAN	Affects Response To Substance	[13]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Affects Activity	[46]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases ADR	[8]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Decreases Response To Substance	[47]
D-beta-hydroxybutyrate dehydrogenase, mitochondrial (BDH1)	OT62RL5P	BDH_HUMAN	Affects Response To Substance	[13]
Melanoma-associated antigen D1 (MAGED1)	OT6EOLFC	MAGD1_HUMAN	Affects Response To Substance	[13]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Affects Response To Substance	[13]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Affects Response To Substance	[13]
Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B)	OT8CMPB2	FKB1B_HUMAN	Affects Response To Substance	[13]
L-lactate dehydrogenase B chain (LDHB)	OT9B1CT3	LDHB_HUMAN	Affects Response To Substance	[13]
Epsilon-sarcoglycan (SGCE)	OT9F17JB	SGCE_HUMAN	Affects Response To Substance	[13]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Response To Substance	[48]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Affects Response To Substance	[49]
Sterol O-acyltransferase 1 (SOAT1)	OTB4Y5RJ	SOAT1_HUMAN	Affects Response To Substance	[13]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)	OTB97VIK	IF2B3_HUMAN	Affects Response To Substance	[13]
Cochlin (COCH)	OTBEHD89	COCH_HUMAN	Affects Response To Substance	[13]
Fibronectin type III domain-containing protein 3B (FNDC3B)	OTBILGDR	FND3B_HUMAN	Affects Response To Substance	[13]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Affects Response To Substance	[13]
Very long chain fatty acid elongase 2 (ELOVL2)	OTDAF6U3	ELOV2_HUMAN	Affects Response To Substance	[13]
Glutathione peroxidase 1 (GPX1)	OTE2O72Q	GPX1_HUMAN	Increases ADR	[8]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Decreases Response To Substance	[50]
Troponin I, fast skeletal muscle (TNNI2)	OTGGZFSC	TNNI2_HUMAN	Increases ADR	[8]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Response To Substance	[51]
Tomoregulin-1 (TMEFF1)	OTH6M3CH	TEFF1_HUMAN	Affects Response To Substance	[13]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Response To Substance	[13]
Ribosomal protein S6 kinase alpha-2 (RPS6KA2)	OTIOYUSU	KS6A2_HUMAN	Affects Response To Substance	[13]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Affects Response To Substance	[52]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Response To Substance	[13]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Affects Response To Substance	[13]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Affects Response To Substance	[13]
Nidogen-1 (NID1)	OTKLBLS6	NID1_HUMAN	Affects Response To Substance	[13]
Glutathione reductase, mitochondrial (GSR)	OTM2TUYM	GSHR_HUMAN	Increases ADR	[8]
Homeobox protein Hox-A1 (HOXA1)	OTMSOJ7D	HXA1_HUMAN	Affects Response To Substance	[13]
Trypsin-3 (PRSS3)	OTN3S5YB	TRY3_HUMAN	Affects Response To Substance	[13]
Melanoma-associated antigen D4 (MAGED4B)	OTO37U7W	MAGD4_HUMAN	Affects Response To Substance	[13]
Opsin-3 (OPN3)	OTON6BFU	OPN3_HUMAN	Affects Response To Substance	[13]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Affects Response To Substance	[53]
Complement factor I (CFI)	OTQYYX0P	CFAI_HUMAN	Affects Response To Substance	[13]
Heat shock-related 70 kDa protein 2 (HSPA2)	OTSDET7B	HSP72_HUMAN	Affects Response To Substance	[13]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Affects Response To Substance	[54]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Affects Response To Substance	[13]
Glycogen debranching enzyme (AGL)	OTWBM7WY	GDE_HUMAN	Affects Response To Substance	[13]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Affects Response To Substance	[13]
Sal-like protein 1 (SALL1)	OTYYZGLH	SALL1_HUMAN	Affects Response To Substance	[13]

Indication(s) of Dasatinib

Disease Entry	ICD 11	Status	REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive	N.A.	Approved	[4]
Brain disease	8C70-8E61	Approved	[4]
Central nervous system disease	8A04-8D87	Approved	[4]
Chronic myelogenous leukaemia	2A20.0	Approved	[5]
Chronic myeloid leukaemia	2A20	Approved	[6]
Glioblastoma	2A00	Approved	[4]
Leukemia	N.A.	Approved	[4]
Lung cancer	2C25.0	Approved	[4]
Non-small-cell lung cancer	2C25.Y	Approved	[4]
Plasma cell myeloma	2A83.1	Approved	[4]
Multiple myeloma	2A83	Phase 2	[5]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[7]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[7]

Dasatinib Interacts with 5 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[58]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[58]
Fusion protein Bcr-Abl (Bcr-Abl)	TTS7G69	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[58]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[58]
HUMAN fusion protein Bcr-Abl (Bcr-Abl)	TTE63HY	BCR_HUMAN/ABL1_HUMAN	Inhibitor	[7]

Dasatinib Interacts with 4 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[59]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[60]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[61]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[61]

Dasatinib Interacts with 4 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[62]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[62]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[62]
Dimethylaniline oxidase 3 (FMO3)	DEP76YL	FMO3_HUMAN	Metabolism	[63]

Dasatinib Interacts with 453 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Tyrosine-protein kinase Fyn (FYN)	OTLSLVZS	FYN_HUMAN	Affects Binding	[55]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)	OTB6YLFT	ENPP3_HUMAN	Decreases Expression	[55]
Tyrosine-protein kinase HCK (HCK)	OTRL6OSI	HCK_HUMAN	Decreases Phosphorylation	[55]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Decreases Expression	[55]
Tyrosine-protein kinase Fgr (FGR)	OTCUYU9F	FGR_HUMAN	Affects Binding	[55]
Heat shock cognate 71 kDa protein (HSPA8)	OTJI2RCI	HSP7C_HUMAN	Affects Binding	[55]
Aminopeptidase N (ANPEP)	OTP3WYFD	AMPN_HUMAN	Decreases Expression	[55]
Tyrosine-protein kinase CSK (CSK)	OTP03OD0	CSK_HUMAN	Affects Binding	[55]
Tyrosine-protein kinase Tec (TEC)	OTU6QJAJ	TEC_HUMAN	Affects Binding	[55]
Tyrosine-protein kinase FRK (FRK)	OTEKV1SC	FRK_HUMAN	Affects Binding	[55]
Ephrin type-A receptor 5 (EPHA5)	OTAM0CVX	EPHA5_HUMAN	Affects Binding	[55]
Ephrin type-B receptor 4 (EPHB4)	OTKLPVXJ	EPHB4_HUMAN	Affects Binding	[55]
Sialomucin core protein 24 (CD164)	OTZ7FIU8	MUC24_HUMAN	Decreases Expression	[55]
Amidophosphoribosyltransferase (PPAT)	OTXK12ZB	PUR1_HUMAN	Affects Binding	[55]
Mitogen-activated protein kinase 14 (MAPK14)	OT5TCO3O	MK14_HUMAN	Affects Binding	[55]
Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)	OT0ALMEG	M3K20_HUMAN	Affects Binding	[55]
ATP-dependent RNA helicase DDX39A (DDX39A)	OT0Z6E1K	DX39A_HUMAN	Decreases Expression	[56]
Cell division cycle 7-related protein kinase (CDC7)	OT5133XY	CDC7_HUMAN	Decreases Expression	[56]
Serine/threonine-protein kinase PLK4 (PLK4)	OTV8KZDZ	PLK4_HUMAN	Decreases Expression	[56]
Nuclear envelope integral membrane protein 1 (NEMP1)	OTWN3S47	NEMP1_HUMAN	Decreases Expression	[56]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Decreases Expression	[56]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[56]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Decreases Expression	[56]
Fanconi anemia group A protein (FANCA)	OTPEFJD4	FANCA_HUMAN	Decreases Expression	[56]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[56]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Decreases Expression	[56]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[56]
Protein sprouty homolog 2 (SPRY2)	OTH0CRCZ	SPY2_HUMAN	Decreases Expression	[56]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[56]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[56]
EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)	OTDVVNS0	EDIL3_HUMAN	Increases Expression	[56]
NUAK family SNF1-like kinase 1 (NUAK1)	OTLLHJJQ	NUAK1_HUMAN	Increases Expression	[56]
Neuropilin-2 (NRP2)	OTZL256E	NRP2_HUMAN	Increases Expression	[56]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[56]
Tetraspanin-2 (TSPAN2)	OTTDPQF1	TSN2_HUMAN	Increases Expression	[56]
Leupaxin (LPXN)	OTUNV3CK	LPXN_HUMAN	Decreases Expression	[56]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[56]
DNA polymerase theta (POLQ)	OTBHK0E6	DPOLQ_HUMAN	Decreases Expression	[56]
Cell division control protein 45 homolog (CDC45)	OT6NNLOD	CDC45_HUMAN	Decreases Expression	[56]
Glypican-4 (GPC4)	OTUJ14DW	GPC4_HUMAN	Increases Expression	[56]
Serpin B7 (SERPINB7)	OTZ95LR2	SPB7_HUMAN	Decreases Expression	[56]
Transient receptor potential cation channel subfamily A member 1 (TRPA1)	OTRDIR5M	TRPA1_HUMAN	Decreases Expression	[56]
Ribonuclease H2 subunit A (RNASEH2A)	OT8G3G7K	RNH2A_HUMAN	Decreases Expression	[56]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[56]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Decreases Expression	[56]
Centrosomal protein of 152 kDa (CEP152)	OTOKZR9B	CE152_HUMAN	Decreases Expression	[56]
Potassium channel subfamily K member 2 (KCNK2)	OTWBT8MG	KCNK2_HUMAN	Decreases Expression	[56]
Chromosome-associated kinesin KIF4A (KIF4A)	OT3UWL7D	KIF4A_HUMAN	Decreases Expression	[56]
Structural maintenance of chromosomes protein 2 (SMC2)	OT5S0DV4	SMC2_HUMAN	Decreases Expression	[56]
Phospholipid-transporting ATPase ABCA1 (ABCA1)	OT94G6BQ	ABCA1_HUMAN	Increases Expression	[56]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Increases Expression	[56]
Securin (PTTG1)	OTIMYS4W	PTTG1_HUMAN	Decreases Expression	[56]
Histone-lysine N-methyltransferase NSD2 (NSD2)	OTQ6SW4R	NSD2_HUMAN	Decreases Expression	[56]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Increases Expression	[56]
Dihydrofolate reductase (DHFR)	OT3DVIGM	DYR_HUMAN	Decreases Expression	[56]
Complement C1r subcomponent (C1R)	OTA0ZNIU	C1R_HUMAN	Increases Expression	[56]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[56]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[56]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Increases Expression	[56]
Collagen alpha-1(III) chain (COL3A1)	OTT1EMLM	CO3A1_HUMAN	Increases Expression	[56]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Increases Expression	[56]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Increases Expression	[56]
Interstitial collagenase (MMP1)	OTI4I2V1	MMP1_HUMAN	Decreases Expression	[56]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[56]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Increases Expression	[56]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Decreases Expression	[56]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[56]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[56]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Increases Expression	[56]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Increases Expression	[56]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Decreases Expression	[56]
Laminin subunit beta-1 (LAMB1)	OT6J9LJR	LAMB1_HUMAN	Increases Expression	[56]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[56]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Increases Expression	[56]
Collagen alpha-2(IV) chain (COL4A2)	OTJK1LKN	CO4A2_HUMAN	Increases Expression	[56]
Platelet-derived growth factor receptor beta (PDGFRB)	OTYSNK9Q	PGFRB_HUMAN	Increases Expression	[56]
Complement C1s subcomponent (C1S)	OTCIZU2A	C1S_HUMAN	Increases Expression	[56]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Decreases Expression	[56]
Histone H2A.Z (H2AZ1)	OT3KJJNQ	H2AZ_HUMAN	Decreases Expression	[56]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Decreases Expression	[56]
Myb-related protein B (MYBL2)	OTZ3JX8Q	MYBB_HUMAN	Decreases Expression	[56]
Histone H1.4 (H1-4)	OTQ450A3	H14_HUMAN	Decreases Expression	[56]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[56]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[56]
Fibroblast growth factor 5 (FGF5)	OTQXGHBY	FGF5_HUMAN	Decreases Expression	[56]
Collagen alpha-1(XI) chain (COL11A1)	OTB0DRMS	COBA1_HUMAN	Increases Expression	[56]
Elastin (ELN)	OTFSO7PG	ELN_HUMAN	Increases Expression	[56]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Increases Expression	[56]
Histone H1.5 (H1-5)	OTAN7RD9	H15_HUMAN	Decreases Expression	[56]
Stathmin (STMN1)	OTDJ4RV0	STMN1_HUMAN	Decreases Expression	[56]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[56]
Biglycan (BGN)	OT3AV6IF	PGS1_HUMAN	Increases Expression	[56]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	OT3MPPYX	ENPP1_HUMAN	Decreases Expression	[56]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Expression	[56]
Integrin alpha-6 (ITGA6)	OT3FA39C	ITA6_HUMAN	Decreases Expression	[56]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Decreases Expression	[56]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Increases Expression	[56]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Expression	[56]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Decreases Expression	[56]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Decreases Expression	[56]
Cardiac phospholamban (PLN)	OTT3RRJN	PPLA_HUMAN	Increases Expression	[56]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Decreases Expression	[56]
Dipeptidyl peptidase 4 (DPP4)	OT16MVL9	DPP4_HUMAN	Increases Expression	[56]
Leiomodin-1 (LMOD1)	OTZ2MEMG	LMOD1_HUMAN	Increases Expression	[56]
M-phase inducer phosphatase 1 (CDC25A)	OTSLKKCO	MPIP1_HUMAN	Decreases Expression	[56]
M-phase inducer phosphatase 3 (CDC25C)	OTPQI71S	MPIP3_HUMAN	Decreases Expression	[56]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[56]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Increases Expression	[56]
Sodium- and chloride-dependent taurine transporter (SLC6A6)	OT67U7G3	SC6A6_HUMAN	Increases Expression	[56]
Cyclin-dependent kinases regulatory subunit 2 (CKS2)	OTPTMHIV	CKS2_HUMAN	Decreases Expression	[56]
Histone H2B type 1-B (H2BC3)	OT1BLFJO	H2B1B_HUMAN	Decreases Expression	[56]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[56]
DNA replication licensing factor MCM7 (MCM7)	OT6FXC6K	MCM7_HUMAN	Decreases Expression	[56]
Syndecan-2 (SDC2)	OTEEHY1D	SDC2_HUMAN	Increases Expression	[56]
Replication factor C subunit 4 (RFC4)	OTWALD2R	RFC4_HUMAN	Decreases Expression	[56]
Replication factor C subunit 2 (RFC2)	OTJ9N6BD	RFC2_HUMAN	Decreases Expression	[56]
Thrombospondin-2 (THBS2)	OTXET551	TSP2_HUMAN	Increases Expression	[56]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Increases Expression	[56]
Myosin-11 (MYH11)	OTVNVWY3	MYH11_HUMAN	Increases Expression	[56]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Increases Expression	[56]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Decreases Expression	[56]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Decreases Expression	[56]
Nicotinamide N-methyltransferase (NNMT)	OTFM38GU	NNMT_HUMAN	Increases Expression	[56]
Pre-B-cell leukemia transcription factor 1 (PBX1)	OTORABGO	PBX1_HUMAN	Increases Expression	[56]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Decreases Expression	[56]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[56]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Increases Expression	[56]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[56]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Increases Expression	[56]
Condensin-2 complex subunit D3 (NCAPD3)	OTOZY2UL	CNDD3_HUMAN	Decreases Expression	[56]
Neutral amino acid transporter A (SLC1A4)	OTVODHAE	SATT_HUMAN	Increases Expression	[56]
Cell surface glycoprotein MUC18 (MCAM)	OTT8XKGE	MUC18_HUMAN	Increases Expression	[56]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[56]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[56]
Glutathione S-transferase Mu 5 (GSTM5)	OTMMBFY8	GSTM5_HUMAN	Increases Expression	[56]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[56]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[56]
DNA primase small subunit (PRIM1)	OTWWP8Y6	PRI1_HUMAN	Decreases Expression	[56]
DNA primase large subunit (PRIM2)	OTGT0KTF	PRI2_HUMAN	Decreases Expression	[56]
Thrombospondin-3 (THBS3)	OTDKMUBD	TSP3_HUMAN	Increases Expression	[56]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[56]
Selenoprotein P (SELENOP)	OT02B8IR	SEPP1_HUMAN	Increases Expression	[56]
Kinetochore-associated protein 1 (KNTC1)	OTI2OOFN	KNTC1_HUMAN	Decreases Expression	[56]
Ras association domain-containing protein 2 (RASSF2)	OT2JHDO4	RASF2_HUMAN	Increases Expression	[56]
DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)	OT4DJFFU	DNA2_HUMAN	Decreases Expression	[56]
Breast cancer type 2 susceptibility protein (BRCA2)	OTF1XSV1	BRCA2_HUMAN	Decreases Expression	[56]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Increases Expression	[56]
Calponin-1 (CNN1)	OTVPG39Z	CNN1_HUMAN	Increases Expression	[56]
Importin subunit alpha-1 (KPNA2)	OTU7FOE6	IMA1_HUMAN	Decreases Expression	[56]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Expression	[56]
High mobility group protein HMGI-C (HMGA2)	OTBMBHHL	HMGA2_HUMAN	Decreases Expression	[56]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[56]
Microfibril-associated glycoprotein 4 (MFAP4)	OT5W64QY	MFAP4_HUMAN	Increases Expression	[56]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Decreases Expression	[56]
Cyclin-dependent kinases regulatory subunit 1 (CKS1B)	OTNUPLUJ	CKS1_HUMAN	Decreases Expression	[56]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[56]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Increases Expression	[56]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Increases Expression	[56]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Increases Expression	[56]
Protein jagged-1 (JAG1)	OT3LGT6K	JAG1_HUMAN	Increases Expression	[56]
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)	OTEUYEW6	ROR1_HUMAN	Increases Expression	[56]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[56]
Kinesin-like protein KIF23 (KIF23)	OTY850JC	KIF23_HUMAN	Decreases Expression	[56]
Histone H1.1 (H1-1)	OTSS815G	H11_HUMAN	Decreases Expression	[56]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Decreases Expression	[56]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Decreases Expression	[56]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Increases Expression	[56]
Prolow-density lipoprotein receptor-related protein 1 (LRP1)	OTHTEH4G	LRP1_HUMAN	Increases Expression	[56]
Forkhead box protein M1 (FOXM1)	OT5887KR	FOXM1_HUMAN	Decreases Expression	[56]
Lactadherin (MFGE8)	OTQKE41R	MFGM_HUMAN	Increases Expression	[56]
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)	OTZVUOOB	FBLN3_HUMAN	Increases Expression	[56]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Decreases Expression	[56]
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)	OTA0UNHM	ECH1_HUMAN	Increases Expression	[56]
MAL-like protein (MALL)	OTKGZ89D	MALL_HUMAN	Decreases Expression	[56]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[56]
Centromere protein R (ITGB3BP)	OT6Q7GR3	CENPR_HUMAN	Decreases Expression	[56]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Decreases Expression	[56]
Limbic system-associated membrane protein (LSAMP)	OTYXVQX2	LSAMP_HUMAN	Increases Expression	[56]
Four and a half LIM domains protein 1 (FHL1)	OTN535SU	FHL1_HUMAN	Increases Expression	[56]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)	OT6KFNMS	CAC1C_HUMAN	Increases Expression	[56]
DNA polymerase alpha subunit B (POLA2)	OTTWQ73N	DPOA2_HUMAN	Decreases Expression	[56]
Fibroleukin (FGL2)	OT8M3H72	FGL2_HUMAN	Increases Expression	[56]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)	OTKUW1WT	PDE3A_HUMAN	Increases Expression	[56]
Semaphorin-3A (SEMA3A)	OTQJSV7W	SEM3A_HUMAN	Decreases Expression	[56]
DNA replication licensing factor MCM6 (MCM6)	OTKLIAWT	MCM6_HUMAN	Decreases Expression	[56]
Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)	OTX7MWW1	ITPR1_HUMAN	Increases Expression	[56]
Maternal embryonic leucine zipper kinase (MELK)	OTEY2UQA	MELK_HUMAN	Decreases Expression	[56]
DNA replication complex GINS protein PSF1 (GINS1)	OTVQZMMQ	PSF1_HUMAN	Decreases Expression	[56]
Transmembrane glycoprotein NMB (GPNMB)	OTB7KQKV	GPNMB_HUMAN	Increases Expression	[56]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Decreases Expression	[56]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[56]
Condensin complex subunit 1 (NCAPD2)	OT8VGE2O	CND1_HUMAN	Decreases Expression	[56]
Disks large-associated protein 5 (DLGAP5)	OTWCN39U	DLGP5_HUMAN	Decreases Expression	[56]
SCL-interrupting locus protein (STIL)	OT9799VN	STIL_HUMAN	Decreases Expression	[56]
Pachytene checkpoint protein 2 homolog (TRIP13)	OTFM3TI9	PCH2_HUMAN	Decreases Expression	[56]
Myosin light chain kinase, smooth muscle (MYLK)	OT78QB4A	MYLK_HUMAN	Increases Expression	[56]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Decreases Expression	[56]
Insulin-like growth factor-binding protein 7 (IGFBP7)	OT1D416P	IBP7_HUMAN	Increases Expression	[56]
Neuronal regeneration-related protein (NREP)	OT2AZPKK	NREP_HUMAN	Increases Expression	[56]
Prostacyclin synthase (PTGIS)	OTT3RW6N	PTGIS_HUMAN	Increases Expression	[56]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[56]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[56]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)	OTJ8LX4N	PCKGM_HUMAN	Increases Expression	[56]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Increases Expression	[56]
Flap endonuclease GEN homolog 1 (GEN1)	OT1XFQXF	GEN_HUMAN	Decreases Expression	[56]
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)	OTCH86VF	AL1L2_HUMAN	Increases Expression	[56]
Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)	OTOBICRD	SVEP1_HUMAN	Increases Expression	[56]
Borealin (CDCA8)	OT17D55D	BOREA_HUMAN	Decreases Expression	[56]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Increases Expression	[56]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[56]
Centromere protein W (CENPW)	OTZL05QN	CENPW_HUMAN	Decreases Expression	[56]
Shugoshin 1 (SGO1)	OTIP6IRN	SGO1_HUMAN	Decreases Expression	[56]
Probable E3 ubiquitin-protein ligase HERC4 (HERC4)	OTU4DSDE	HERC4_HUMAN	Decreases Expression	[56]
Testis-expressed protein 30 (TEX30)	OT87WEPQ	TEX30_HUMAN	Decreases Expression	[56]
DEP domain-containing protein 1A (DEPDC1)	OT0JWE1B	DEP1A_HUMAN	Decreases Expression	[56]
Tensin-3 (TNS3)	OTPG2D8Z	TENS3_HUMAN	Increases Expression	[56]
Cell division cycle-associated protein 2 (CDCA2)	OTX8UF9J	CDCA2_HUMAN	Decreases Expression	[56]
Protein FAM72D (FAM72D)	OTCQVOXB	FA72D_HUMAN	Decreases Expression	[56]
Repulsive guidance molecule B (RGMB)	OT2DROYU	RGMB_HUMAN	Decreases Expression	[56]
STEAP family member 1B (STEAP1B)	OTZJDFWK	STEAL_HUMAN	Decreases Expression	[56]
Mis18-binding protein 1 (MIS18BP1)	OT41T0FB	M18BP_HUMAN	Decreases Expression	[56]
Mitochondrial fission regulator 2 (MTFR2)	OTLOR68D	MTFR2_HUMAN	Decreases Expression	[56]
Rho GTPase-activating protein 11A (ARHGAP11A)	OTVQCFVP	RHGBA_HUMAN	Decreases Expression	[56]
E3 ubiquitin-protein ligase RFWD3 (RFWD3)	OTDUULBQ	RFWD3_HUMAN	Decreases Expression	[56]
Podocan-like protein 1 (PODNL1)	OTL72ES9	PONL1_HUMAN	Increases Expression	[56]
Protein aurora borealis (BORA)	OTV2ZPKP	BORA_HUMAN	Decreases Expression	[56]
Neutral cholesterol ester hydrolase 1 (NCEH1)	OTZ66CKX	NCEH1_HUMAN	Decreases Expression	[56]
Fidgetin-like protein 1 (FIGNL1)	OTKII63K	FIGL1_HUMAN	Decreases Expression	[56]
ATPase family AAA domain-containing protein 2 (ATAD2)	OT8MCRNY	ATAD2_HUMAN	Decreases Expression	[56]
Serine protease FAM111B (FAM111B)	OT9IQ9NV	F111B_HUMAN	Decreases Expression	[56]
Protein FAM180A (FAM180A)	OTKQ7XUG	F180A_HUMAN	Decreases Expression	[56]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Increases Expression	[56]
Plexin domain-containing protein 2 (PLXDC2)	OTS1FUV6	PXDC2_HUMAN	Increases Expression	[56]
ALK and LTK ligand 1 (ALKAL1)	OTZGAZ79	ALKL1_HUMAN	Increases Expression	[56]
Protein MMS22-like (MMS22L)	OTJI0HM9	MMS22_HUMAN	Decreases Expression	[56]
Centrosomal protein of 128 kDa (CEP128)	OT922YCJ	CE128_HUMAN	Decreases Expression	[56]
DNA-binding protein RFX8 (RFX8)	OT27SFGQ	RFX8_HUMAN	Decreases Expression	[56]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Decreases Expression	[56]
Protein MCM10 homolog (MCM10)	OTV0O3JN	MCM10_HUMAN	Decreases Expression	[56]
Treslin (TICRR)	OT2HKWOC	TICRR_HUMAN	Decreases Expression	[56]
MAM domain-containing protein 2 (MAMDC2)	OT4GICNY	MAMC2_HUMAN	Increases Expression	[56]
LisH domain-containing protein ARMC9 (ARMC9)	OT0MZER2	ARMC9_HUMAN	Increases Expression	[56]
Rho GTPase-activating protein 22 (ARHGAP22)	OTXUQEFL	RHG22_HUMAN	Decreases Expression	[56]
Podocan (PODN)	OTV3P7P5	PODN_HUMAN	Increases Expression	[56]
Schlafen family member 11 (SLFN11)	OTJWFPMY	SLN11_HUMAN	Decreases Expression	[56]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Increases Expression	[56]
Alpha-protein kinase 2 (ALPK2)	OTWZZDQ9	ALPK2_HUMAN	Increases Expression	[56]
Myopalladin (MYPN)	OTHTOFDU	MYPN_HUMAN	Decreases Expression	[56]
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)	OT89V4N5	MARH3_HUMAN	Decreases Expression	[56]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3)	OT4RZV2M	IQGA3_HUMAN	Decreases Expression	[56]
Condensin-2 complex subunit G2 (NCAPG2)	OTZYENKO	CNDG2_HUMAN	Decreases Expression	[56]
GAS2-like protein 3 (GAS2L3)	OTWPVI29	GA2L3_HUMAN	Decreases Expression	[56]
Histone H2A type 2-B (H2AC21)	OTH7W2NJ	H2A2B_HUMAN	Decreases Expression	[56]
Pleckstrin homology domain-containing family H member 2 (PLEKHH2)	OT3TK3NN	PKHH2_HUMAN	Increases Expression	[56]
Extracellular sulfatase Sulf-2 (SULF2)	OTIXMUVL	SULF2_HUMAN	Increases Expression	[56]
Extracellular sulfatase Sulf-1 (SULF1)	OTJCNCO0	SULF1_HUMAN	Increases Expression	[56]
CD302 antigen (CD302)	OTX580VU	CD302_HUMAN	Increases Expression	[56]
Spindle and kinetochore-associated protein 3 (SKA3)	OTLHEVJD	SKA3_HUMAN	Decreases Expression	[56]
DNA damage-induced apoptosis suppressor protein (DDIAS)	OTTGG2PM	DDIAS_HUMAN	Decreases Expression	[56]
Cytoskeleton-associated protein 2-like (CKAP2L)	OT4T73GG	CKP2L_HUMAN	Decreases Expression	[56]
Fanconi anemia group M protein (FANCM)	OTNJG99Z	FANCM_HUMAN	Decreases Expression	[56]
Lung adenoma susceptibility protein 2 (C18ORF54)	OT4WJKTF	LAS2_HUMAN	Decreases Expression	[56]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Decreases Expression	[56]
Retinol dehydrogenase 10 (RDH10)	OTL9FSGF	RDH10_HUMAN	Increases Expression	[56]
Centromere protein L (CENPL)	OT7P006B	CENPL_HUMAN	Decreases Expression	[56]
Rho GTPase-activating protein 18 (ARHGAP18)	OTYMJP6H	RHG18_HUMAN	Decreases Expression	[56]
T-complex protein 11-like protein 2 (TCP11L2)	OTTIZO7B	T11L2_HUMAN	Increases Expression	[56]
Aminopeptidase O (AOPEP)	OT0MMANL	AMPO_HUMAN	Increases Expression	[56]
Junction-mediating and -regulatory protein (JMY)	OTH5FFVK	JMY_HUMAN	Increases Expression	[56]
Holliday junction recognition protein (HJURP)	OTWMV16B	HJURP_HUMAN	Decreases Expression	[56]
SHC SH2 domain-binding protein 1 (SHCBP1)	OT3A21CM	SHCBP_HUMAN	Decreases Expression	[56]
MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)	OTVXEF85	MDGA1_HUMAN	Increases Expression	[56]
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Increases Expression	[56]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Increases Expression	[56]
Protein CIP2A (CIP2A)	OTVS2GXA	CIP2A_HUMAN	Decreases Expression	[56]
Sodium-dependent phosphate transporter 1 (SLC20A1)	OTC3D894	S20A1_HUMAN	Decreases Expression	[56]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[56]
Basic helix-loop-helix ARNT-like protein 2 (BMAL2)	OTIBDGQC	BMAL2_HUMAN	Decreases Expression	[56]
Centromere protein I (CENPI)	OTWRIMZ3	CENPI_HUMAN	Decreases Expression	[56]
Serine protease HTRA1 (HTRA1)	OTR8ACBF	HTRA1_HUMAN	Increases Expression	[56]
Hyaluronan synthase 2 (HAS2)	OTTD3PAL	HYAS2_HUMAN	Decreases Expression	[56]
Neogenin (NEO1)	OTGJ1997	NEO1_HUMAN	Increases Expression	[56]
Histone H2B type 1-H (H2BC9)	OTQ9XX72	H2B1H_HUMAN	Decreases Expression	[56]
F-box only protein 32 (FBXO32)	OTUE978R	FBX32_HUMAN	Increases Expression	[56]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[56]
Transcription factor E2F7 (E2F7)	OTWW358N	E2F7_HUMAN	Decreases Expression	[56]
Spindle and kinetochore-associated protein 1 (SKA1)	OTDYJ12A	SKA1_HUMAN	Decreases Expression	[56]
Mdm2-binding protein (MTBP)	OTWLCW9C	MTBP_HUMAN	Decreases Expression	[56]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Decreases Expression	[56]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[56]
Serine/threonine-protein kinase greatwall (MASTL)	OTQ7YKK5	GWL_HUMAN	Decreases Expression	[56]
Centromere protein N (CENPN)	OTRO7XPD	CENPN_HUMAN	Decreases Expression	[56]
Proline-rich protein 11 (PRR11)	OT2JJ08Z	PRR11_HUMAN	Decreases Expression	[56]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Decreases Expression	[56]
Leucine-rich repeat protein 1 (LRR1)	OTSWDXVY	LLR1_HUMAN	Decreases Expression	[56]
Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)	OT5TS6P7	PCMD1_HUMAN	Increases Expression	[56]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)	OTB71I02	DCBD2_HUMAN	Decreases Expression	[56]
Kinesin-like protein KIF20B (KIF20B)	OTS68AHH	KI20B_HUMAN	Decreases Expression	[56]
ATPase family AAA domain-containing protein 5 (ATAD5)	OTI8ABKF	ATAD5_HUMAN	Decreases Expression	[56]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Increases Expression	[56]
Hyaluronan and proteoglycan link protein 3 (HAPLN3)	OTB853Z1	HPLN3_HUMAN	Increases Expression	[56]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Decreases Expression	[56]
Cell division cycle-associated protein 3 (CDCA3)	OTUI8QK3	CDCA3_HUMAN	Decreases Expression	[56]
Kinesin-like protein KIF2C (KIF2C)	OTJ8G3NP	KIF2C_HUMAN	Decreases Expression	[56]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Decreases Expression	[56]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Increases Expression	[56]
Histone H2B type 1-M (H2BC14)	OTSDZZZY	H2B1M_HUMAN	Decreases Expression	[56]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Decreases Expression	[56]
Mitochondrial genome maintenance exonuclease 1 (MGME1)	OTC5LPXX	MGME1_HUMAN	Decreases Expression	[56]
Synaptotagmin-15 (SYT15)	OT7Q088G	SYT15_HUMAN	Increases Expression	[56]
Hephaestin (HEPH)	OTZ2F15Z	HEPH_HUMAN	Increases Expression	[56]
DNA replication complex GINS protein SLD5 (GINS4)	OTCVOO3S	SLD5_HUMAN	Decreases Expression	[56]
Centromere protein K (CENPK)	OTKPUF8K	CENPK_HUMAN	Decreases Expression	[56]
Protein PIMREG (PIMREG)	OTKC8T3E	PIMRE_HUMAN	Decreases Expression	[56]
Nucleoporin NDC1 (NDC1)	OTF2GQC1	NDC1_HUMAN	Decreases Expression	[56]
Centromere protein O (CENPO)	OTXAH83Y	CENPO_HUMAN	Decreases Expression	[56]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[56]
TIMELESS-interacting protein (TIPIN)	OT9PZHXV	TIPIN_HUMAN	Decreases Expression	[56]
Kinesin-like protein KIFC1 (KIFC1)	OTNQDS00	KIFC1_HUMAN	Decreases Expression	[56]
Meiotic nuclear division protein 1 homolog (MND1)	OTS87F3H	MND1_HUMAN	Decreases Expression	[56]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[56]
Fanconi anemia group D2 protein (FANCD2)	OTVEB5LF	FACD2_HUMAN	Decreases Expression	[56]
Transmembrane 6 superfamily member 1 (TM6SF1)	OTQR4I2N	TM6S1_HUMAN	Increases Expression	[56]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Increases Expression	[56]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Decreases Expression	[56]
Centromere protein H (CENPH)	OTPOO9LK	CENPH_HUMAN	Decreases Expression	[56]
Kinetochore-associated protein DSN1 homolog (DSN1)	OTHROI0H	DSN1_HUMAN	Decreases Expression	[56]
Uncharacterized protein C1orf198 (C1ORF198)	OTK3L4G7	CA198_HUMAN	Increases Expression	[56]
Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)	OTFTH6ZY	GAPR1_HUMAN	Increases Expression	[56]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Decreases Expression	[56]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Increases Expression	[56]
Gremlin-2 (GREM2)	OTE91EWT	GREM2_HUMAN	Increases Expression	[56]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Increases Expression	[56]
Protein ECT2 (ECT2)	OTQDUCT6	ECT2_HUMAN	Decreases Expression	[56]
Claspin (CLSPN)	OTZZXNDK	CLSPN_HUMAN	Decreases Expression	[56]
Mineralization regulator ANKH (ANKH)	OTCN25R5	ANKH_HUMAN	Increases Expression	[56]
Ribonucleoprotein PTB-binding 2 (RAVER2)	OT0MDL7K	RAVR2_HUMAN	Increases Expression	[56]
Neurexin-3-beta (NRXN3)	OTJ0I7HJ	NRX3B_HUMAN	Increases Expression	[56]
Solute carrier family 40 member 1 (SLC40A1)	OT8RV2VY	S40A1_HUMAN	Increases Expression	[56]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[56]
Phospholipid scramblase 4 (PLSCR4)	OT2AMYLY	PLS4_HUMAN	Increases Expression	[56]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[56]
FIGNL1-interacting regulator of recombination and mitosis (FIRRM)	OTALLHT1	FIRRM_HUMAN	Decreases Expression	[56]
Protein diaphanous homolog 3 (DIAPH3)	OTPOT23F	DIAP3_HUMAN	Decreases Expression	[56]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[56]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[56]
Tyrosyl-DNA phosphodiesterase 1 (TDP1)	OTYINMBR	TYDP1_HUMAN	Decreases Expression	[56]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Decreases Expression	[56]
Histone chaperone ASF1B (ASF1B)	OTKXX12I	ASF1B_HUMAN	Decreases Expression	[56]
PCNA-interacting partner (PARPBP)	OTPZDGW7	PARI_HUMAN	Decreases Expression	[56]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[56]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Increases Expression	[56]
Protein Mis18-alpha (MIS18A)	OTD80K5X	MS18A_HUMAN	Decreases Expression	[56]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Decreases Expression	[56]
Programmed cell death 1 ligand 1 (CD274)	OTJ0VFDL	PD1L1_HUMAN	Decreases Expression	[56]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Increases Expression	[56]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)	OT1PAIN0	CACO1_HUMAN	Increases Expression	[56]
Homologous-pairing protein 2 homolog (PSMC3IP)	OT9UB5UO	HOP2_HUMAN	Decreases Expression	[56]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Increases Expression	[56]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	OTHLNI51	ABC3B_HUMAN	Decreases Expression	[56]
STEAP1 protein (STEAP1)	OTJMW5R9	STEA1_HUMAN	Decreases Expression	[56]
Carboxypeptidase A4 (CPA4)	OT66MP0F	CBPA4_HUMAN	Decreases Expression	[56]
DNA helicase MCM8 (MCM8)	OTC93H3S	MCM8_HUMAN	Decreases Expression	[56]
F-box only protein 5 (FBXO5)	OTTR957W	FBX5_HUMAN	Decreases Expression	[56]
Angiopoietin-related protein 2 (ANGPTL2)	OTB6JG41	ANGL2_HUMAN	Increases Expression	[56]
Integrin alpha-11 (ITGA11)	OTBWSRA1	ITA11_HUMAN	Increases Expression	[56]
Protein HEG homolog 1 (HEG1)	OT3CUXA7	HEG1_HUMAN	Increases Expression	[56]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[56]
Synaptopodin-2 (SYNPO2)	OTC3U0YH	SYNP2_HUMAN	Increases Expression	[56]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)	OT953SV2	ATS5_HUMAN	Increases Expression	[56]
Protein timeless homolog (TIMELESS)	OTD8DCBJ	TIM_HUMAN	Decreases Expression	[56]
LIM and calponin homology domains-containing protein 1 (LIMCH1)	OTYPC4XA	LIMC1_HUMAN	Increases Expression	[56]
Exonuclease 1 (EXO1)	OTI87RS5	EXO1_HUMAN	Decreases Expression	[56]
Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)	OTEU05TX	PPR3C_HUMAN	Increases Expression	[56]
Transcription factor 19 (TCF19)	OT7NKLF9	TCF19_HUMAN	Decreases Expression	[56]
DNA replication complex GINS protein PSF2 (GINS2)	OT974IYI	PSF2_HUMAN	Decreases Expression	[56]
Serine/threonine-protein kinase 38-like (STK38L)	OTI00JVW	ST38L_HUMAN	Increases Expression	[56]
Small kinetochore-associated protein (KNSTRN)	OTYA7UXS	SKAP_HUMAN	Decreases Expression	[56]
Origin recognition complex subunit 6 (ORC6)	OTKQN3KP	ORC6_HUMAN	Decreases Expression	[56]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[56]
Carboxypeptidase Q (CPQ)	OTTNZNLD	CBPQ_HUMAN	Increases Expression	[56]
Transforming acidic coiled-coil-containing protein 3 (TACC3)	OTRNEZTA	TACC3_HUMAN	Decreases Expression	[56]
Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)	OTMRW5U5	IRAG1_HUMAN	Increases Expression	[56]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Decreases Expression	[56]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[64]
Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)	OTFBFPV4	ADAS_HUMAN	Increases Expression	[65]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Decreases Expression	[65]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[65]
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)	OT5BZ1J9	P85A_HUMAN	Decreases Phosphorylation	[65]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Decreases Phosphorylation	[65]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[65]
cAMP-regulated phosphoprotein 19 (ARPP19)	OTZS3IT6	ARP19_HUMAN	Increases Expression	[65]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Increases Expression	[66]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Affects Localization	[67]
Tyrosine-protein kinase ABL1 (ABL1)	OT09YVXH	ABL1_HUMAN	Decreases Activity	[68]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Decreases Expression	[66]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Activity	[69]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[70]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[70]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Increases Expression	[66]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[70]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[71]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Decreases Expression	[70]
Cathepsin B (CTSB)	OTP9G5QB	CATB_HUMAN	Decreases Expression	[72]
Tyrosine-protein kinase Lyn (LYN)	OTP686K2	LYN_HUMAN	Decreases Activity	[57]
Hepatocyte growth factor receptor (MET)	OT7K55MU	MET_HUMAN	Decreases Phosphorylation	[73]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[70]
High mobility group protein B1 (HMGB1)	OT4B7CPF	HMGB1_HUMAN	Increases Expression	[74]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Activity	[72]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Decreases Expression	[70]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[75]
Mast/stem cell growth factor receptor Kit (KIT)	OTHUY3VZ	KIT_HUMAN	Decreases Phosphorylation	[76]
Integrin alpha-M (ITGAM)	OTAG6HWU	ITAM_HUMAN	Increases Expression	[66]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Activity	[68]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Decreases Expression	[70]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Activity	[72]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Decreases Expression	[70]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Decreases Expression	[70]
Platelet-derived growth factor receptor alpha (PDGFRA)	OTDJXUCN	PGFRA_HUMAN	Decreases Phosphorylation	[77]
C-C motif chemokine 1 (CCL1)	OT23NON8	CCL1_HUMAN	Decreases Expression	[70]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[78]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[57]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[57]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Decreases Expression	[70]
G1/S-specific cyclin-D3 (CCND3)	OTNKPQ22	CCND3_HUMAN	Decreases Expression	[78]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Phosphorylation	[76]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Phosphorylation	[79]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Phosphorylation	[75]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[68]
Tyrosine-protein kinase ABL2 (ABL2)	OTS8F4GD	ABL2_HUMAN	Affects Binding	[80]
Crk-like protein (CRKL)	OTOYSD1R	CRKL_HUMAN	Decreases Phosphorylation	[81]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[78]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[70]
Paxillin (PXN)	OTVMMUOF	PAXI_HUMAN	Decreases Phosphorylation	[79]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Cleavage	[57]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[82]
Interleukin-2 (IL2)	OTGI4NSA	IL2_HUMAN	Decreases Expression	[70]
Small ribosomal subunit protein eS6 (RPS6)	OTT4D1LN	RS6_HUMAN	Decreases Phosphorylation	[70]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Phosphorylation	[69]
Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)	OT4Y9NQI	MP2K1_HUMAN	Increases Phosphorylation	[66]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Phosphorylation	[78]
Early activation antigen CD69 (CD69)	OTGJHSVP	CD69_HUMAN	Decreases Expression	[70]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[57]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[57]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[82]
Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1)	OTF91GTL	FIP1_HUMAN	Decreases Phosphorylation	[77]
Bile acid receptor (NR1H4)	OTWZLPTB	NR1H4_HUMAN	Decreases Phosphorylation	[83]
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)	OTYRXD2T	PMYT1_HUMAN	Decreases Activity	[84]
Transcription factor SOX-17 (SOX17)	OT9H4WWE	SOX17_HUMAN	Decreases Localization	[85]
Diablo IAP-binding mitochondrial protein (DIABLO)	OTHJ9MCZ	DBLOH_HUMAN	Affects Localization	[67]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Response To Substance	[78]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)	OTK3EJFD	NSDHL_HUMAN	Decreases Response To Substance	[86]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Decreases Response To Substance	[86]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adenocarcinoma	DCAZ3FI	NCIH520	Investigative	[1]
Adenocarcinoma	DCEM6O5	COLO320DM	Investigative	[1]
Adenocarcinoma	DC6VOZT	SW-620	Investigative	[1]
Malignant melanoma	DC2AFQV	SKMEL30	Investigative	[1]
Ovarian endometrioid adenocarcinoma	DC37J6G	A2780	Investigative	[1]
Prostate carcinoma	DCD4ZWN	VCAP	Investigative	[1]
Breast carcinoma	DC5WTCJ	ZR751	Investigative	[87]
Carcinoma	DC4F547	EFM192B	Investigative	[87]

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