Details of the Drug Combination

General Information of Drug Combination (ID: DC18QC2)

Drug Combination Name
Torcetrapib Idarubicin
Indication
Disease Entry Status REF
Glioblastoma? Investigative [1]
Component Drugs Torcetrapib   DMDHYM7 Idarubicin   DMM0XGL
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: T98G
Zero Interaction Potency (ZIP) Score: 17.94
Bliss Independence Score: 17.94
Loewe Additivity Score: 9.22
LHighest Single Agent (HSA) Score: 9.22

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Torcetrapib
Disease Entry ICD 11 Status REF
Hyperlipidaemia 5C80 Discontinued in Phase 2 [2]
Peripheral vascular disease BD4Z Discontinued in Phase 2 [2]
Torcetrapib Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cholesteryl ester transfer protein (CETP) TTFQAYR CETP_HUMAN Inhibitor [7]
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Torcetrapib Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [8]
------------------------------------------------------------------------------------
Torcetrapib Interacts with 304 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
CCN family member 1 (CCN1) OTKJBEMD CCN1_HUMAN Increases Expression [5]
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Increases Expression [5]
Cytochrome P450 11B2, mitochondrial (CYP11B2) OTIOLWYN C11B2_HUMAN Increases Expression [5]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1) OTGP6GA4 NR4A1_HUMAN Increases Expression [5]
Nuclear receptor subfamily 4 group A member 2 (NR4A2) OT3F9IR2 NR4A2_HUMAN Increases Expression [5]
GTP-binding protein GEM (GEM) OT6SK8ZV GEM_HUMAN Increases Expression [5]
Rho-related GTP-binding protein RhoB (RHOB) OTHQFQF7 RHOB_HUMAN Increases Expression [5]
Peptidyl-prolyl cis-trans isomerase A (PPIA) OTHJMWQQ PPIA_HUMAN Increases Expression [5]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Increases Expression [5]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [5]
Nitric oxide synthase 3 (NOS3) OTLDT7NR NOS3_HUMAN Decreases Expression [9]
Ciliary microtubule inner protein 2B (CIMIP2B) OTMN8WBM CMI2B_HUMAN Increases Expression [6]
Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) OTB97VIK IF2B3_HUMAN Increases Expression [6]
Golgi integral membrane protein 4 (GOLIM4) OTB5NV8A GOLI4_HUMAN Increases Expression [6]
AP-3 complex subunit delta-1 (AP3D1) OTJLI0IM AP3D1_HUMAN Increases Expression [6]
Transportin-2 (TNPO2) OTGHFQAV TNPO2_HUMAN Increases Expression [6]
Ras-related protein M-Ras (MRAS) OTNCVCQW RASM_HUMAN Increases Expression [6]
Probable proton-coupled zinc antiporter SLC30A4 (SLC30A4) OTUYJNBS ZNT4_HUMAN Increases Expression [6]
Peripheral plasma membrane protein CASK (CASK) OT8EF7ZF CSKP_HUMAN Increases Expression [6]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [6]
Period circadian protein homolog 2 (PER2) OTU2B1DJ PER2_HUMAN Increases Expression [6]
Suppressor of cytokine signaling 1 (SOCS1) OTWA9KFU SOCS1_HUMAN Increases Expression [6]
Leucine-rich repeat transmembrane protein FLRT2 (FLRT2) OTGD8TID FLRT2_HUMAN Increases Expression [6]
RNA binding protein fox-1 homolog 2 (RBFOX2) OTXY1WVH RFOX2_HUMAN Increases Expression [6]
Trans-Golgi network integral membrane protein 2 (TGOLN2) OTM647IV TGON2_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase RNF13 (RNF13) OT7HNYF4 RNF13_HUMAN Increases Expression [6]
Protein sprouty homolog 2 (SPRY2) OTH0CRCZ SPY2_HUMAN Increases Expression [6]
17S U2 SnRNP complex component HTATSF1 (HTATSF1) OTLQ1ZLS HTSF1_HUMAN Increases Expression [6]
Double-strand-break repair protein rad21 homolog (RAD21) OTQS84ZF RAD21_HUMAN Increases Expression [6]
Microphthalmia-associated transcription factor (MITF) OT6XJCZH MITF_HUMAN Increases Expression [6]
DnaJ homolog subfamily C member 13 (DNAJC13) OTYAVVJ6 DJC13_HUMAN Increases Expression [6]
Phosphatase and actin regulator 2 (PHACTR2) OTWMX2A8 PHAR2_HUMAN Increases Expression [6]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [6]
Bis(monoacylglycero)phosphate synthase CLN5 (CLN5) OTY265P6 CLN5_HUMAN Increases Expression [6]
Krueppel-like factor 7 (KLF7) OTS3YVA0 KLF7_HUMAN Increases Expression [6]
Serine hydrolase RBBP9 (RBBP9) OT0Z04L6 RBBP9_HUMAN Increases Expression [6]
Ubiquitin-like protein ATG12 (ATG12) OTJRO09Y ATG12_HUMAN Increases Expression [6]
Cyclin-dependent kinase 14 (CDK14) OT385ZH1 CDK14_HUMAN Increases Expression [6]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [6]
Transferrin receptor protein 1 (TFRC) OT8ZPBDL TFR1_HUMAN Increases Expression [6]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [6]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Increases Expression [6]
Complement decay-accelerating factor (CD55) OTZ3HWTO DAF_HUMAN Increases Expression [6]
Inhibin beta A chain (INHBA) OTSP64PQ INHBA_HUMAN Increases Expression [6]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Increases Expression [6]
Putative inactive neutral ceramidase B (ASAH2B) OT2M9WWQ ASA2B_HUMAN Increases Expression [6]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [6]
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT) OT4KZ5R9 ODB2_HUMAN Increases Expression [6]
Nucleoprotein TPR (TPR) OTUBBA4W TPR_HUMAN Increases Expression [6]
Poliovirus receptor (PVR) OT3N91T7 PVR_HUMAN Increases Expression [6]
Fos-related antigen 2 (FOSL2) OT3MT9HJ FOSL2_HUMAN Increases Expression [6]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Expression [6]
Histone H1.3 (H1-3) OTT7VPRB H13_HUMAN Increases Expression [6]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) OTPGAU0U AT2A2_HUMAN Increases Expression [6]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Increases Expression [6]
Tyrosine-protein phosphatase non-receptor type 2 (PTPN2) OTV4VJGE PTN2_HUMAN Increases Expression [6]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [6]
Ras-related protein Rab-3B (RAB3B) OTZA4SXL RAB3B_HUMAN Increases Expression [6]
Cation-dependent mannose-6-phosphate receptor (M6PR) OTFEWOSB MPRD_HUMAN Increases Expression [6]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase CBL (CBL) OTTKELCU CBL_HUMAN Increases Expression [6]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Increases Expression [6]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Increases Expression [6]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Increases Expression [6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [6]
Rab proteins geranylgeranyltransferase component A 2 (CHML) OTW3VW8D RAE2_HUMAN Increases Expression [6]
Microtubule-associated protein 4 (MAP4) OT78YX9J MAP4_HUMAN Increases Expression [6]
Protein ITPRID2 (ITPRID2) OTO3JDX5 ITPI2_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [6]
Tripeptidyl-peptidase 2 (TPP2) OT91OVAU TPP2_HUMAN Increases Expression [6]
Fibroblast growth factor 9 (FGF9) OT2SKDGM FGF9_HUMAN Increases Expression [6]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Increases Expression [6]
ETS-related transcription factor Elf-1 (ELF1) OTV5LKIA ELF1_HUMAN Increases Expression [6]
Cystathionine gamma-lyase (CTH) OTC90LA0 CGL_HUMAN Increases Expression [6]
Merlin (NF2) OT6E5ACG MERL_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase TRIM23 (TRIM23) OTVIGJ4T TRI23_HUMAN Increases Expression [6]
TGF-beta receptor type-2 (TGFBR2) OT3P7GZP TGFR2_HUMAN Increases Expression [6]
Interleukin-6 receptor subunit beta (IL6ST) OT1N9C70 IL6RB_HUMAN Increases Expression [6]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [6]
Endothelin-converting enzyme 1 (ECE1) OTPFHC6F ECE1_HUMAN Increases Expression [6]
Transcriptional regulator ATRX (ATRX) OT77RSQW ATRX_HUMAN Increases Expression [6]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Increases Expression [6]
DNA-binding protein inhibitor ID-4 (ID4) OTPMJ39I ID4_HUMAN Increases Expression [6]
Glioma pathogenesis-related protein 1 (GLIPR1) OT0FGQK7 GLIP1_HUMAN Increases Expression [6]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Increases Expression [6]
Protein Tob1 (TOB1) OTNW949D TOB1_HUMAN Increases Expression [6]
Ras-related protein Rab-5C (RAB5C) OTQE5QQ2 RAB5C_HUMAN Increases Expression [6]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) OT7PZZ4K PSMD7_HUMAN Increases Expression [6]
AF4/FMR2 family member 2 (AFF2) OTMF1PZW AFF2_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase TTC3 (TTC3) OTTR9WUC TTC3_HUMAN Increases Expression [6]
Puromycin-sensitive aminopeptidase (NPEPPS) OTMENFXR PSA_HUMAN Increases Expression [6]
Serine/threonine-protein kinase SIK1 (SIK1) OT6FCHME SIK1_HUMAN Increases Expression [6]
Epiplakin (EPPK1) OT7BAU8C EPIPL_HUMAN Increases Expression [6]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [6]
DDB1- and CUL4-associated factor 7 (DCAF7) OT3W5DYL DCAF7_HUMAN Increases Expression [6]
Tropomyosin alpha-4 chain (TPM4) OTN4YLYR TPM4_HUMAN Increases Expression [6]
Coxsackievirus and adenovirus receptor (CXADR) OT9ZP02A CXAR_HUMAN Increases Expression [6]
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B) OTF1VGJ9 PI42B_HUMAN Increases Expression [6]
Arginase-2, mitochondrial (ARG2) OTCPI0E8 ARGI2_HUMAN Increases Expression [6]
Protein BTG2 (BTG2) OTZF6K1H BTG2_HUMAN Increases Expression [6]
Interleukin-13 receptor subunit alpha-1 (IL13RA1) OT59OYXP I13R1_HUMAN Increases Expression [6]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Increases Expression [6]
Cyclin-dependent kinase 6 (CDK6) OTR95N0X CDK6_HUMAN Increases Expression [6]
OTU domain-containing protein 4 (OTUD4) OT7U62SW OTUD4_HUMAN Increases Expression [6]
Myocyte-specific enhancer factor 2A (MEF2A) OTV2SF6E MEF2A_HUMAN Increases Expression [6]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Expression [6]
Histone-lysine N-methyltransferase 2A (KMT2A) OT9GLJI6 KMT2A_HUMAN Increases Expression [6]
Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1) OT2CF1E6 IF4G1_HUMAN Increases Expression [6]
Transducin-like enhancer protein 4 (TLE4) OT4QEH6T TLE4_HUMAN Increases Expression [6]
Proto-oncogene c-Rel (REL) OTTCKMAC REL_HUMAN Increases Expression [6]
Caldesmon (CALD1) OTNJKJ6Q CALD1_HUMAN Increases Expression [6]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Increases Expression [6]
Golgin subfamily A member 2 (GOLGA2) OT5S9KYM GOGA2_HUMAN Increases Expression [6]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Increases Expression [6]
Leukocyte surface antigen CD47 (CD47) OTLDZ0KZ CD47_HUMAN Increases Expression [6]
TP53-binding protein 1 (TP53BP1) OTL8879S TP53B_HUMAN Increases Expression [6]
Interleukin enhancer-binding factor 3 (ILF3) OTKMZ5K5 ILF3_HUMAN Increases Expression [6]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Expression [6]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Increases Expression [6]
Zinc transporter ZIP6 (SLC39A6) OTCYF466 S39A6_HUMAN Increases Expression [6]
DNA topoisomerase 3-alpha (TOP3A) OT3CKUI9 TOP3A_HUMAN Increases Expression [6]
Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D) OTJ5XLVU KCC2D_HUMAN Increases Expression [6]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Increases Expression [6]
ARF GTPase-activating protein GIT2 (GIT2) OTQ2EQJ1 GIT2_HUMAN Increases Expression [6]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) OTD1KRKO DYHC1_HUMAN Increases Expression [6]
RNA-binding protein 39 (RBM39) OTCMPTF9 RBM39_HUMAN Increases Expression [6]
Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2) OTPHGZ19 ITPR2_HUMAN Increases Expression [6]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Increases Expression [6]
Chromodomain-helicase-DNA-binding protein 4 (CHD4) OTBDEHDP CHD4_HUMAN Increases Expression [6]
HUWE1-associated protein modifying stress responses 1 (HAPSTR1) OTWCI7ZA HAPR1_HUMAN Increases Expression [6]
Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) OTC1AM7S SART3_HUMAN Increases Expression [6]
Pericentriolar material 1 protein (PCM1) OTFM133C PCM1_HUMAN Increases Expression [6]
Angiopoietin-1 (ANGPT1) OTVZ1NG3 ANGP1_HUMAN Increases Expression [6]
Tyrosine-protein phosphatase non-receptor type 14 (PTPN14) OTR0BMH1 PTN14_HUMAN Increases Expression [6]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Increases Expression [6]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [6]
snRNA-activating protein complex subunit 1 (SNAPC1) OTAPN1NI SNPC1_HUMAN Increases Expression [6]
Beta-sarcoglycan (SGCB) OT5R5LAT SGCB_HUMAN Increases Expression [6]
Nuclear factor interleukin-3-regulated protein (NFIL3) OTQH9HM3 NFIL3_HUMAN Increases Expression [6]
kinase isozyme 4, mitochondrial (PDK4) OTCMHMBZ PDK4_HUMAN Increases Expression [6]
Gamma-interferon-inducible protein 16 (IFI16) OT4SPU0U IF16_HUMAN Increases Expression [6]
Cytoplasmic polyadenylation element-binding protein 4 (CPEB4) OTW1SCZW CPEB4_HUMAN Increases Expression [6]
LON peptidase N-terminal domain and RING finger protein 2 (LONRF2) OT95PP0W LONF2_HUMAN Increases Expression [6]
Hereditary hemochromatosis protein (HFE) OTDD93KB HFE_HUMAN Increases Expression [6]
Erythroid differentiation-related factor 1 (EDRF1) OTM7TWJZ EDRF1_HUMAN Increases Expression [6]
Chromodomain-helicase-DNA-binding protein 9 (CHD9) OTWNFDKJ CHD9_HUMAN Increases Expression [6]
Girdin (CCDC88A) OT3SSYYC GRDN_HUMAN Increases Expression [6]
AT-rich interactive domain-containing protein 4B (ARID4B) OTYLPILE ARI4B_HUMAN Increases Expression [6]
Rho GTPase-activating protein 29 (ARHGAP29) OT8JH4TY RHG29_HUMAN Increases Expression [6]
INO80 complex subunit D (INO80D) OTY39R4P IN80D_HUMAN Increases Expression [6]
Exosome complex component MTR3 (EXOSC6) OTAC10N6 EXOS6_HUMAN Increases Expression [6]
Opioid growth factor receptor-like protein 1 (OGFRL1) OT6QGBYE OGRL1_HUMAN Increases Expression [6]
Telomere-associated protein RIF1 (RIF1) OTPE49OE RIF1_HUMAN Increases Expression [6]
Muscleblind-like protein 2 (MBNL2) OTF7CF1F MBNL2_HUMAN Increases Expression [6]
Centriole, cilia and spindle-associated protein (CCSAP) OTE72F4O CCSAP_HUMAN Increases Expression [6]
Glucose 1,6-bisphosphate synthase (PGM2L1) OTSBNRT5 PGM2L_HUMAN Increases Expression [6]
Kelch domain-containing protein 10 (KLHDC10) OTLDF1OX KLD10_HUMAN Increases Expression [6]
Consortin (CNST) OTOUCB98 CNST_HUMAN Increases Expression [6]
Kelch-like protein 24 (KLHL24) OTWZSX5C KLH24_HUMAN Increases Expression [6]
Ankyrin repeat domain-containing protein 11 (ANKRD11) OTV0V70M ANR11_HUMAN Increases Expression [6]
Very-long-chain (HACD2) OTAZO9F6 HACD2_HUMAN Increases Expression [6]
Membrane progestin receptor epsilon (PAQR9) OTLY2CZM PAQR9_HUMAN Increases Expression [6]
Lysophosphatidylcholine acyltransferase 2 (LPCAT2) OT6NTBAA PCAT2_HUMAN Increases Expression [6]
Probable helicase senataxin (SETX) OTG3JNOQ SETX_HUMAN Increases Expression [6]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP) OTZ4BG4B PARPT_HUMAN Increases Expression [6]
SUZ domain-containing protein 1 (SZRD1) OTJMEJWT SZRD1_HUMAN Increases Expression [6]
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) OTKX7P8G SPRE1_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase RBBP6 (RBBP6) OTTVG4HU RBBP6_HUMAN Increases Expression [6]
UPF0461 protein C5orf24 (C5ORF24) OT8DXIAT CE024_HUMAN Increases Expression [6]
Protein prenyltransferase alpha subunit repeat-containing protein 1 (PTAR1) OTCT7YPX PTAR1_HUMAN Increases Expression [6]
Uncharacterized protein C11orf96 (C11ORF96) OTEQU0V7 CK096_HUMAN Increases Expression [6]
Protein PAT1 homolog 1 (PATL1) OT11Z3XX PATL1_HUMAN Increases Expression [6]
RNA N6-adenosine-methyltransferase METTL16 (METTL16) OT99VP8Y MET16_HUMAN Increases Expression [6]
Liprin-beta-1 (PPFIBP1) OTRA2S7B LIPB1_HUMAN Increases Expression [6]
CDK2-associated and cullin domain-containing protein 1 (CACUL1) OT6P1ZVP CACL1_HUMAN Increases Expression [6]
ELKS/Rab6-interacting/CAST family member 1 (ERC1) OTYBGGNO RB6I2_HUMAN Increases Expression [6]
Protein NOXP20 (FAM114A1) OT0208Y4 NXP20_HUMAN Increases Expression [6]
Angiomotin-like protein 1 (AMOTL1) OT40G45S AMOL1_HUMAN Increases Expression [6]
Fanconi anemia group M protein (FANCM) OTNJG99Z FANCM_HUMAN Increases Expression [6]
ORM1-like protein 3 (ORMDL3) OTAB7MZF ORML3_HUMAN Increases Expression [6]
Mitochondrial cardiolipin hydrolase (PLD6) OTER78DB PLD6_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase RNF152 (RNF152) OTF8I14F RN152_HUMAN Increases Expression [6]
Protein SCAI (SCAI) OTAK3TMO SCAI_HUMAN Increases Expression [6]
NFATC2-interacting protein (NFATC2IP) OTOQ4AZ9 NF2IP_HUMAN Increases Expression [6]
EH domain-binding protein 1 (EHBP1) OTMNUJ15 EHBP1_HUMAN Increases Expression [6]
Polyhomeotic-like protein 3 (PHC3) OTTTLIAP PHC3_HUMAN Increases Expression [6]
Protein Lines homolog 1 (LINS1) OT1USO08 LINES_HUMAN Increases Expression [6]
Small VCP/p97-interacting protein (SVIP) OTVKVR34 SVIP_HUMAN Increases Expression [6]
DnaJ homolog subfamily B member 14 (DNAJB14) OTAC2K95 DJB14_HUMAN Increases Expression [6]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Increases Expression [6]
Protein bicaudal D homolog 2 (BICD2) OTVJ03NZ BICD2_HUMAN Increases Expression [6]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [6]
Splicing regulatory glutamine/lysine-rich protein 1 (SREK1) OT3F6ZCB SREK1_HUMAN Increases Expression [6]
Stonin-2 (STON2) OT01JHHE STON2_HUMAN Increases Expression [6]
Cysteine/serine-rich nuclear protein 3 (CSRNP3) OTOANEHZ CSRN3_HUMAN Increases Expression [6]
Protein ELYS (AHCTF1) OTATTQL1 ELYS_HUMAN Increases Expression [6]
Protein LZIC (LZIC) OTT07ZC7 LZIC_HUMAN Increases Expression [6]
Immunity-related GTPase family Q protein (IRGQ) OT92NI0W IRGQ_HUMAN Increases Expression [6]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [6]
Amyloid beta precursor protein binding family B member 2 (APBB2) OT1VD51B APBB2_HUMAN Increases Expression [6]
SWI/SNF complex subunit SMARCC1 (SMARCC1) OTUOMBE7 SMRC1_HUMAN Increases Expression [6]
Protein tyrosine phosphatase type IVA 1 (PTP4A1) OTK0NFXJ TP4A1_HUMAN Increases Expression [6]
Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10) OTYKLW1K FKB10_HUMAN Increases Expression [6]
Ataxin-7-like protein 3B (ATXN7L3B) OTUYOYAR A7L3B_HUMAN Increases Expression [6]
PDZ and LIM domain protein 5 (PDLIM5) OTLQVV22 PDLI5_HUMAN Increases Expression [6]
Terminal nucleotidyltransferase 5A (TENT5A) OTSYF511 TET5A_HUMAN Increases Expression [6]
Serine/Arginine-related protein 53 (RSRC1) OTFCJ4S0 RSRC1_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase Itchy homolog (ITCH) OTUOMKF5 ITCH_HUMAN Increases Expression [6]
ADP-ribosylation factor-like protein 5B (ARL5B) OTYYBIDG ARL5B_HUMAN Increases Expression [6]
E1A-binding protein p400 (EP400) OTVQ75NX EP400_HUMAN Increases Expression [6]
CCR4-NOT transcription complex subunit 6-like (CNOT6L) OTLBRR6Q CNO6L_HUMAN Increases Expression [6]
Sphingomyelin synthase-related protein 1 (SAMD8) OTGJTVEN SAMD8_HUMAN Increases Expression [6]
Prickle-like protein 1 (PRICKLE1) OT9HHEM9 PRIC1_HUMAN Increases Expression [6]
Germ cell nuclear acidic protein (GCNA) OTIU3F9Y GCNA_HUMAN Increases Expression [6]
Transcriptional regulator protein Pur-beta (PURB) OTCDDKYB PURB_HUMAN Increases Expression [6]
Tribbles homolog 1 (TRIB1) OTPEO17G TRIB1_HUMAN Increases Expression [6]
Cysteine/serine-rich nuclear protein 1 (CSRNP1) OTDK1FPH CSRN1_HUMAN Increases Expression [6]
Protein IWS1 homolog (IWS1) OTF96EYX IWS1_HUMAN Increases Expression [6]
Centrosomal protein of 89 kDa (CEP89) OT1VEFSL CEP89_HUMAN Increases Expression [6]
Sphingosine 1-phosphate receptor 3 (S1PR3) OTXBIYO8 S1PR3_HUMAN Increases Expression [6]
Protein SCAF11 (SCAF11) OTX59D0X SCAFB_HUMAN Increases Expression [6]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [6]
Suppressor of IKBKE 1 (SIKE1) OT5O11J0 SIKE1_HUMAN Increases Expression [6]
Dynactin subunit 5 (DCTN5) OTESGJ1N DCTN5_HUMAN Increases Expression [6]
tRNA (THUMPD3) OTRC7TRW THUM3_HUMAN Increases Expression [6]
Cell cycle regulator of non-homologous end joining (CYREN) OT5ZL00R CYREN_HUMAN Increases Expression [6]
Poly(A) polymerase gamma (PAPOLG) OTIV69YA PAPOG_HUMAN Increases Expression [6]
Protein LSM14 homolog B (LSM14B) OTW646HP LS14B_HUMAN Increases Expression [6]
N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) OT53SIZG NAA15_HUMAN Increases Expression [6]
FSD1-like protein (FSD1L) OTBQ48RF FSD1L_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 16 (DUSP16) OTK7S078 DUS16_HUMAN Increases Expression [6]
NF-kappa-B inhibitor zeta (NFKBIZ) OTU728KS IKBZ_HUMAN Increases Expression [6]
F-box-like/WD repeat-containing protein TBL1XR1 (TBL1XR1) OTM3B3OA TBL1R_HUMAN Increases Expression [6]
Tripartite motif-containing protein 2 (TRIM2) OT0V1YVC TRIM2_HUMAN Increases Expression [6]
Egl nine homolog 1 (EGLN1) OT5QODDK EGLN1_HUMAN Increases Expression [6]
Nucleoporin-62 C-terminal-like protein (NUP62CL) OTEN1HET N62CL_HUMAN Increases Expression [6]
Homeodomain-interacting protein kinase 2 (HIPK2) OTDB7QC3 HIPK2_HUMAN Increases Expression [6]
Protein salvador homolog 1 (SAV1) OTSAEV92 SAV1_HUMAN Increases Expression [6]
HEAT repeat-containing protein 1 (HEATR1) OTOWIB9Z HEAT1_HUMAN Increases Expression [6]
Threonine aspartase 1 (TASP1) OTOX7946 TASP1_HUMAN Increases Expression [6]
Serine-rich coiled-coil domain-containing protein 2 (CCSER2) OT8RPWLY CCSE2_HUMAN Increases Expression [6]
Jupiter microtubule associated homolog 2 (JPT2) OTJGPA4T JUPI2_HUMAN Increases Expression [6]
Akirin-1 (AKIRIN1) OTINWTT9 AKIR1_HUMAN Increases Expression [6]
Pleckstrin homology domain-containing family A member 2 (PLEKHA2) OTY2AP6T PKHA2_HUMAN Increases Expression [6]
Putative divalent cation/proton antiporter TMEM165 (TMEM165) OTMVJ0GA TM165_HUMAN Increases Expression [6]
Casein kinase I isoform gamma-1 (CSNK1G1) OTCXB7BI KC1G1_HUMAN Increases Expression [6]
SIN3-HDAC complex-associated factor (SINHCAF) OTHMZZ0A SHCAF_HUMAN Increases Expression [6]
Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) OT5V52LN TNR12_HUMAN Increases Expression [6]
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase (AASDHPPT) OTA6OR6C ADPPT_HUMAN Increases Expression [6]
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3) OTAUR5TG PLCC_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase RNF19A (RNF19A) OTKWCV80 RN19A_HUMAN Increases Expression [6]
Septin-11 (SEPTIN11) OTX2O0ZX SEP11_HUMAN Increases Expression [6]
F-box only protein 28 (FBXO28) OTKTMVC4 FBX28_HUMAN Increases Expression [6]
Exonuclease 3'-5' domain-containing protein 2 (EXD2) OTEM0BTG EXD2_HUMAN Increases Expression [6]
HAUS augmin-like complex subunit 2 (HAUS2) OT2OOLFJ HAUS2_HUMAN Increases Expression [6]
DDB1- and CUL4-associated factor 16 (DCAF16) OT60PR7J DCA16_HUMAN Increases Expression [6]
Inhibitor of growth protein 3 (ING3) OTDIJXFP ING3_HUMAN Increases Expression [6]
Serine/threonine-protein kinase PLK2 (PLK2) OTKMJXJ8 PLK2_HUMAN Increases Expression [6]
]-phosphatase 1, mitochondrial (PDP1) OT82RTMT PDP1_HUMAN Increases Expression [6]
SLAIN motif-containing protein 2 (SLAIN2) OTSM5QIO SLAI2_HUMAN Increases Expression [6]
Leucine--tRNA ligase, cytoplasmic (LARS1) OT4557NF SYLC_HUMAN Increases Expression [6]
Myotilin (MYOT) OTCEW5XW MYOTI_HUMAN Increases Expression [6]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 (GNG12) OTOGF42G GBG12_HUMAN Increases Expression [6]
Protein sel-1 homolog 1 (SEL1L) OTC0FB7T SE1L1_HUMAN Increases Expression [6]
Probable ribosome biogenesis protein RLP24 (RSL24D1) OT6KI56F RLP24_HUMAN Increases Expression [6]
LIM domain and actin-binding protein 1 (LIMA1) OTONPC9R LIMA1_HUMAN Increases Expression [6]
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) OTTZVSK6 S2513_HUMAN Increases Expression [6]
F-box/LRR-repeat protein 4 (FBXL4) OTZECCIQ FBXL4_HUMAN Increases Expression [6]
DnaJ homolog subfamily C member 12 (DNAJC12) OTNU59PT DJC12_HUMAN Increases Expression [6]
DCC-interacting protein 13-alpha (APPL1) OT8VR95S DP13A_HUMAN Increases Expression [6]
Muskelin (MKLN1) OTHMIMH6 MKLN1_HUMAN Increases Expression [6]
Protein BCAP (ODF2L) OTJLJ65L ODF2L_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase HECTD1 (HECTD1) OTJ95JJS HECD1_HUMAN Increases Expression [6]
Frizzled-10 (FZD10) OTSAENLT FZD10_HUMAN Increases Expression [6]
Unconventional myosin-VI (MYO6) OTJQYRC7 MYO6_HUMAN Increases Expression [6]
Translocon-associated protein subunit gamma (SSR3) OTJQP0IZ SSRG_HUMAN Increases Expression [6]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [6]
RAC-gamma serine/threonine-protein kinase (AKT3) OT5M2LFI AKT3_HUMAN Increases Expression [6]
Mitogen-activated protein kinase kinase kinase 2 (MAP3K2) OTI7MCML M3K2_HUMAN Increases Expression [6]
PRELI domain containing protein 3B (PRELID3B) OT4TRT4K PLD3B_HUMAN Increases Expression [6]
Pygopus homolog 1 (PYGO1) OT8L4L2R PYGO1_HUMAN Increases Expression [6]
TRPM8 channel-associated factor 1 (TCAF1) OTSQQ37P TCAF1_HUMAN Increases Expression [6]
Nuclear protein AMMECR1 (AMMECR1) OTWMQ67T AMMR1_HUMAN Increases Expression [6]
Protein PRRC2C (PRRC2C) OTBX3MXM PRC2C_HUMAN Increases Expression [6]
Low-density lipoprotein receptor-related protein 12 (LRP12) OTRT1UJ7 LRP12_HUMAN Increases Expression [6]
Krueppel-like factor 2 (KLF2) OTIP1UFX KLF2_HUMAN Increases Expression [6]
Sorting nexin-13 (SNX13) OTB7IB7X SNX13_HUMAN Increases Expression [6]
EP300-interacting inhibitor of differentiation 1 (EID1) OT3OI5H4 EID1_HUMAN Increases Expression [6]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [6]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Increases Expression [10]
Cytochrome b-245 heavy chain (CYBB) OTGSG868 CY24B_HUMAN Increases Expression [10]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Increases Expression [10]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Increases Expression [10]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Increases Phosphorylation [10]
NADPH oxidase 5 (NOX5) OTHTH59G NOX5_HUMAN Increases Expression [10]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Increases Expression [10]
NADPH oxidase 4 (NOX4) OTTYQ097 NOX4_HUMAN Increases Expression [10]
NADPH oxidase 1 (NOX1) OTZPJQCC NOX1_HUMAN Increases Expression [10]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1) OTZKVLVJ CP17A_HUMAN Increases Expression [11]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Increases Expression [11]
Steroid 21-hydroxylase (CYP21A2) OTN0UDVP CP21A_HUMAN Increases Expression [11]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Increases Expression [11]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Increases Expression [11]
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C) OT6KFNMS CAC1C_HUMAN Increases Expression [12]
------------------------------------------------------------------------------------
⏷ Show the Full List of 304 DOT(s)
Indication(s) of Idarubicin
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [3]
Acute myeloid leukaemia 2A60 Approved [4]
Adult acute monocytic leukemia N.A. Approved [3]
Childhood acute megakaryoblastic leukemia N.A. Approved [3]
Leukemia N.A. Approved [3]
Idarubicin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [14]
------------------------------------------------------------------------------------
Idarubicin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [15]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [16]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [16]
------------------------------------------------------------------------------------
Idarubicin Interacts with 2 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [17]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [17]
------------------------------------------------------------------------------------
Idarubicin Interacts with 9 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Activity [13]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [18]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Increases Activity [13]
Natriuretic peptides B (NPPB) OTSN2IPY ANFB_HUMAN Increases Expression [19]
Peroxisome proliferator-activated receptor gamma (PPARG) OTHMARHO PPARG_HUMAN Decreases Activity [13]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [20]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Decreases Activity [13]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Decreases Activity [21]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Activity [13]
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⏷ Show the Full List of 9 DOT(s)

References

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2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015157)
3 Idarubicin FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7083).
5 Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9.
6 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
7 Safety and tolerability of dalcetrapib. Am J Cardiol. 2009 Jul 1;104(1):82-91.
8 Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans. Drug Metab Dispos. 2008 Nov;36(11):2185-98.
9 Torcetrapib impairs endothelial function in hypertension. Eur Heart J. 2012 Jul;33(13):1615-24.
10 Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 2015 Apr;353(1):27-34.
11 Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
12 Mechanisms underlying off-target effects of the cholesteryl ester transfer protein inhibitor torcetrapib involve L-type calcium channels. J Hypertens. 2010 Aug;28(8):1676-86. doi: 10.1097/HJH.0b013e32833b1f8e.
13 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
14 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
15 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
16 Amonafide L-malate is not a substrate for multidrug resistance proteins in secondary acute myeloid leukemia. Leukemia. 2008 Nov;22(11):2110-5.
17 In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21.
18 A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. J Am Soc Nephrol. 2016 Apr;27(4):1015-28. doi: 10.1681/ASN.2015010060. Epub 2015 Aug 10.
19 The use of biochemical markers in cardiotoxicity monitoring in patients treated for leukemia. Neoplasma. 2005;52(5):430-4.
20 The induction of apoptosis by daunorubicin and idarubicin in human trisomic and diabetic fibroblasts. Cell Mol Biol Lett. 2008;13(2):182-94. doi: 10.2478/s11658-007-0045-7. Epub 2008 Apr 10.
21 Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.