General Information of Drug (ID: DMD1E4J)

Drug Name
UNC0379 Drug Info
Synonyms
1620401-82-2; 6,7-Dimethoxy-2-(pyrrolidin-1-yl)-N-(5-(pyrrolidin-1-yl)pentyl)quinazolin-4-amine; UNC-0379; CHEMBL3318285; UNC 0379; 6,7-Dimethoxy-2-pyrrolidin-1-yl-N-(5-pyrrolidin-1-ylpentyl)quinazolin-4-amine; C23H35N5O2; 4-Quinazolinamine, 6,7-dimethoxy-2-(1-pyrrolidinyl)-N-[5-(1-pyrrolidinyl)pentyl]-; CS-3345; HY-12335; SCHEMBL22568439; AOB6365; EX-A461; SYN5081; BCP10429; 3362AH; BDBM50051117; MFCD28167817; s7570; ZINC98214604; AKOS025404942; UNC 0379;UNC-0379; CCG-268809; SB19349; NCGC00384189-06; NCGC00384189-10; AK174945; AS-16447; DA-43617; B8009; FT-0699830; A14320; UNC0379 trifluoroacetate salt, >=98% (HPLC)
Indication
Disease Entry ICD 11 Status REF
Hepatocellular carcinoma 2C12.02 Preclinical [1]
Cross-matching ID
PubChem CID
78357767
TTD Drug ID
DMD1E4J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Preclinical Drug(s)
Investigative Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
MS2177 DMDEJBQ Solid tumour/cancer 2A00-2F9Z Preclinical [1]
nahuoic acid A DM1LWMU Discovery agent N.A. Investigative [3]
MS453 DMBTPDL Discovery agent N.A. Investigative [4]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [10]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [11]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [14]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [16]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
chlordane DMMHU8G Discovery agent N.A. Investigative [16]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [17]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [18]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [19]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [20]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [21]
Selenium DM25CGV N. A. N. A. Approved [22]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [23]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [23]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [32]
Fluoxetine DM3PD2C Bipolar depression Approved [33]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [36]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [38]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [43]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [41]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [40]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [44]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [34]
Menthol DMG2KW7 Back pain ME84.Z Approved [46]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [48]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Folic Acid DMEMBJC Colorectal carcinoma Approved [52]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ethanol DMDRQZU Chronic pain MG30 Approved [53]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [25]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [57]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [25]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [58]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Arsenic DMTL2Y1 N. A. N. A. Approved [59]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [60]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
AHPN DM8G6O4 Discovery agent N.A. Investigative [62]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [45]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Desogestrel DM27U4Y Contraception QA21 Approved [63]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [65]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [66]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dantrolene DM1D8XY Hyperthermia MG26 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [71]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [72]
Testosterone DM7HUNW Hot flushes GA30 Approved [73]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Folic Acid DMEMBJC Colorectal carcinoma Approved [75]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [77]
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [79]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [80]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [81]
Paclitaxel DMLB81S Breast carcinoma Approved [82]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [83]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [84]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [85]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.0 (H1-0)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ethanol DMDRQZU Chronic pain MG30 Approved [53]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor 1 C-type (NFIC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Panobinostat DM58WKG Chronic graft versus host disease Approved [93]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [95]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [96]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [99]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.4 (H1-4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [76]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [87]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [103]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [104]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [107]
Etretinate DM2CZFA Keratosis ED56 Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [109]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [110]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [111]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [112]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [115]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Panobinostat DM58WKG Chronic graft versus host disease Approved [44]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [116]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ski oncogene (SKI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [117]
Selenium DM25CGV N. A. N. A. Approved [25]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [118]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 2 (FOSL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [5]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [40]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
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Drug(s) Affected By Protein SON (SON)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [40]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [40]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [124]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Panobinostat DM58WKG Chronic graft versus host disease Approved [125]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [48]
Deferasirox DM6ETS0 Beta thalassemia 3A50.2 Approved [127]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [129]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [130]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [131]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alvimopan DMHR8KW Gastrointestinal disease DE2Z Approved [132]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [133]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [136]
Oliceridine DM6MDCF Acute pain MG31 Approved [133]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [139]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [141]
Gefitinib DM15F0X Colon adenocarcinoma Approved [142]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Etretinate DM2CZFA Keratosis ED56 Approved [144]
Prednisone DM2HG4X Acute asthma CA23 Approved [145]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [146]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate receptor 2 (GRIA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [147]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [149]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [150]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [25]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [151]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [152]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [154]
Propranolol DM79NTF Angina pectoris BA40 Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [156]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [157]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Mebendazole DMO14SG Ascariasis 1F62 Approved [159]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Placenta growth factor (PGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [161]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [162]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hexokinase-2 (HK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Epinephrine DM3KJBC Acute asthma CA23 Approved [163]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [164]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [165]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [166]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Atrophin-1 (ATN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [45]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [150]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [168]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [169]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [13]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [170]
Fluoxetine DM3PD2C Bipolar depression Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [171]
Quercetin DM3NC4M Obesity 5B81 Approved [172]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Panobinostat DM58WKG Chronic graft versus host disease Approved [173]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [174]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [175]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [176]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [5]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [177]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [177]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 4F2 (CYP4F2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [178]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [179]
Ethanol DMDRQZU Chronic pain MG30 Approved [180]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [34]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [7]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [6]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG2 (BTG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [181]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [182]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [183]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [102]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [185]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [186]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [186]
Quercetin DM3NC4M Obesity 5B81 Approved [187]
Fluoxetine DM3PD2C Bipolar depression Approved [186]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [34]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [123]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [188]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [189]
Selenium DM25CGV N. A. N. A. Approved [25]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [190]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [191]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Panobinostat DM58WKG Chronic graft versus host disease Approved [44]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [192]
Estrone DM5T6US Acne vulgaris ED80 Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [78]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [193]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [194]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [179]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [187]
Fluoxetine DM3PD2C Bipolar depression Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [196]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [40]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor 1 X-type (NFIX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [199]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [28]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [200]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Benzatropine DMF7EXL Parkinsonian disorder Approved [185]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [97]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Fluoxetine DM3PD2C Bipolar depression Approved [33]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [35]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [37]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [201]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [202]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [203]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [204]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [205]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [206]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [207]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [208]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [169]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [205]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [152]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [179]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [209]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Testosterone enanthate DMB6871 N. A. N. A. Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [28]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [179]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [210]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [211]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [210]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [179]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [212]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
OTX-015 DMI8RG1 Acute myeloid leukaemia 2A60 Phase 1/2 [213]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [214]
Mivebresib DMCPF90 Acute myeloid leukaemia 2A60 Phase 1 [213]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [215]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Helicase SRCAP (SRCAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [216]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [13]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [152]
Milchsaure DM462BT Pruritus EC90 Investigative [217]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [218]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [211]
Folic Acid DMEMBJC Colorectal carcinoma Approved [52]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [220]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [220]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [40]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [221]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [179]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [185]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Testosterone DM7HUNW Hot flushes GA30 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [179]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [223]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [44]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [224]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [225]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [40]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [42]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [126]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [202]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [87]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [227]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [204]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [211]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [44]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [33]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [35]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [228]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [229]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [48]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [211]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [87]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [230]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [152]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Nectin-4 (NECTIN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [231]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [179]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Ethanol DMDRQZU Chronic pain MG30 Approved [232]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-L2 (CCNL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [233]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [234]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [235]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [209]
Testosterone enanthate DMB6871 N. A. N. A. Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [74]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [156]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [236]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [237]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [238]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [239]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [240]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [241]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [95]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Arsenic DMTL2Y1 N. A. N. A. Approved [243]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [92]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [216]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [244]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BolA-like protein 2 (BOLA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [114]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [245]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [95]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [152]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [246]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [56]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [247]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [28]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [211]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
GSK2110183 DMZHB37 leukaemia 2A60-2B33 Phase 2 [248]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [197]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [206]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ethanol DMDRQZU Chronic pain MG30 Approved [249]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [224]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [40]
Arsenic DMTL2Y1 N. A. N. A. Approved [250]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [251]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [17]
Methotrexate DM2TEOL Anterior urethra cancer Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Testosterone DM7HUNW Hot flushes GA30 Approved [39]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [39]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [40]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [233]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [152]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Quercetin DM3NC4M Obesity 5B81 Approved [13]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [90]
Arsenic DMTL2Y1 N. A. N. A. Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [97]
Urethane DM7NSI0 N. A. N. A. Phase 4 [31]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ProSAAS (PCSK1N)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [253]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [234]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [6]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [119]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [13]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [13]
⏷ Show the Full List of 6 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [25]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Ethanol DMDRQZU Chronic pain MG30 Approved [254]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [156]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [245]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [255]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [61]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [12]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [256]
Selenium DM25CGV N. A. N. A. Approved [25]
Methotrexate DM2TEOL Anterior urethra cancer Approved [24]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [94]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [95]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [257]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [29]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [8]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [258]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [259]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [44]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [260]
⏷ Show the Full List of 7 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [42]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [120]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [191]
Leflunomide DMR8ONJ Arthritis FA20 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [261]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [262]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [263]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [168]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [88]
Panobinostat DM58WKG Chronic graft versus host disease Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [5]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [15]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [245]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [158]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [222]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [26]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [264]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [50]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [265]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [131]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [9]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [258]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [230]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [266]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
SET domain containing 8 (KMT5A) TTGC95K KMT5A_HUMAN Inhibitor [1]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7) OTV7VOV3 DHB7_HUMAN Gene/Protein Processing [2]
Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B) OT3SQMLU AN32B_HUMAN Gene/Protein Processing [2]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [2]
Adenomatous polyposis coli protein 2 (APC2) OTRH91CX APCL_HUMAN Gene/Protein Processing [2]
Apical endosomal glycoprotein (MAMDC4) OTTL3DWT AEGP_HUMAN Gene/Protein Processing [2]
Arginine-glutamic acid dipeptide repeats protein (RERE) OT3G4GBZ RERE_HUMAN Gene/Protein Processing [2]
ATP synthase subunit delta, mitochondrial (ATP5F1D) OTXTAG2V ATPD_HUMAN Gene/Protein Processing [2]
Atrophin-1 (ATN1) OTNZFLKY ATN1_HUMAN Gene/Protein Processing [2]
BCL-6 corepressor-like protein 1 (BCORL1) OTPTFQN5 BCORL_HUMAN Gene/Protein Processing [2]
BolA-like protein 2 (BOLA2) OTVZP6YB BOLA2_HUMAN Gene/Protein Processing [2]

References

1 Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat Rev Drug Discov. 2021 Apr;20(4):265-286.
2 Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma. Cancer Cell. 2017 Jan 9;31(1):50-63.
3 Nahuoic acid A produced by a Streptomyces sp. isolated from a marine sediment is a selective SAM-competitive inhibitor of the histone methyltransferase SETD8. Org Lett. 2013 Jan 18;15(2):414-7.
4 Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase. J Med Chem. 2016 Nov 10;59(21):9881-9889.
5 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
6 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
7 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
8 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
9 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
10 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
11 BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52.
12 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
13 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
14 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
15 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
16 Xenobiotic CAR activators induce Dlk1-Dio3 locus noncoding RNA expression in mouse liver. Toxicol Sci. 2017 Aug 1;158(2):367-378.
17 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
18 Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
19 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
20 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
21 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
22 Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
23 Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
24 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
25 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
26 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
27 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
28 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
29 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
30 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
31 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
32 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
33 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
34 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
35 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
36 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
37 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
38 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
39 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
40 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
41 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
42 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
43 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
44 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
45 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
46 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
47 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
48 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
49 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
50 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
51 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
52 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
53 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
54 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
55 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
56 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
57 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
58 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
59 Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
60 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
61 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
62 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
63 Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
64 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
65 Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. J Biol Chem. 2020 Nov 20;295(47):15870-15882. doi: 10.1074/jbc.RA120.015623. Epub 2020 Sep 10.
66 Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
67 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
68 Insulin-like growth factors (IGF) I and II utilize different calcium signaling pathways in a primary human parathyroid cell culture model. World J Surg. 2006 Mar;30(3):333-45. doi: 10.1007/s00268-005-0339-8.
69 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
70 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
71 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
72 Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells. Int J Cancer. 1997 Dec 10;73(6):880-4. doi: 10.1002/(sici)1097-0215(19971210)73:6<880::aid-ijc20>3.0.co;2-7.
73 Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Eur J Endocrinol. 2005 Apr;152(4):597-604. doi: 10.1530/eje.1.01880.
74 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
75 Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the IGF2 gene in the very young child. PLoS One. 2009 Nov 16;4(11):e7845. doi: 10.1371/journal.pone.0007845.
76 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
77 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
78 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
79 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
80 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
81 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
82 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
83 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
84 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
85 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
86 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
87 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
88 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
89 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
90 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
91 Characterisation of human histone H1x. Biol Chem. 2005 Jun;386(6):541-51. doi: 10.1515/BC.2005.064.
92 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
93 The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
94 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
95 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
96 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
97 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
98 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
99 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
100 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
101 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
102 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
103 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
104 Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
105 Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
106 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
107 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
108 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
109 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
110 Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
111 [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
112 Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
113 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
114 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
115 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
116 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
117 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
118 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
119 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
120 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
121 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
122 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
123 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
124 Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in HeLa cells. J Cell Physiol. 1994 Mar;158(3):417-26. doi: 10.1002/jcp.1041580305.
125 Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
126 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
127 Iron chelators ICL670 and 311 inhibit HIV-1 transcription. Virology. 2007 Oct 25;367(2):324-33. doi: 10.1016/j.virol.2007.06.011. Epub 2007 Jul 13.
128 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
129 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
130 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
131 New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
132 The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone. Naunyn Schmiedebergs Arch Pharmacol. 2007 May;375(3):205-20. doi: 10.1007/s00210-007-0146-x. Epub 2007 Mar 6.
133 A G protein-biased ligand at the ?-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17.
134 Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther. 2008 Apr;83(4):559-66.
135 The effect of mitragynine on cAMP formation and mRNA expression of mu-opioid receptors mediated by chronic morphine treatment in SK-N-SH neuroblastoma cell. J Ethnopharmacol. 2013 Jun 21;148(1):135-43. doi: 10.1016/j.jep.2013.03.078. Epub 2013 Apr 19.
136 In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances. Arch Toxicol. 2020 Nov;94(11):3819-3830. doi: 10.1007/s00204-020-02855-7. Epub 2020 Jul 31.
137 Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol. 2006 Apr;69(4):1486-91. doi: 10.1124/mol.105.018325. Epub 2006 Jan 24.
138 Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. Neuroimmunomodulation. 2012;19(3):180-6. doi: 10.1159/000331474. Epub 2012 Jan 18.
139 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
140 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
141 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
142 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
143 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
144 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
145 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
146 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
147 THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons. Mol Neuropsychiatry. 2017 Nov;3(2):73-84. doi: 10.1159/000477762. Epub 2017 Jul 20.
148 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
149 Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. J Neurochem. 2005 Dec;95(6):1785-93. doi: 10.1111/j.1471-4159.2005.03517.x.
150 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
151 Disruption of glutamate neurotransmitter transmission is modulated by SNAP-25 in benzo[a]pyrene-induced neurotoxic effects. Toxicology. 2017 Jun 1;384:11-22. doi: 10.1016/j.tox.2017.03.021. Epub 2017 Apr 19.
152 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
153 Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1alpha. Neuroscience. 2014 Sep 26;277:780-93.
154 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
155 Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
156 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
157 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
158 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
159 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
160 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
161 Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
162 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
163 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
164 Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15084-9. doi: 10.1073/pnas.1521316112. Epub 2015 Nov 23.
165 Combination of imatinib and clotrimazole enhances cell growth inhibition in T47D breast cancer cells. Chem Biol Interact. 2015 May 25;233:147-56. doi: 10.1016/j.cbi.2015.03.028. Epub 2015 Apr 8.
166 Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation. Environ Toxicol. 2022 Apr;37(4):754-764. doi: 10.1002/tox.23440. Epub 2021 Dec 14.
167 Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
168 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
169 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
170 Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
171 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
172 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
173 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
174 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol. 2019 Mar;234(3):2606-2617. doi: 10.1002/jcp.27073. Epub 2018 Oct 14.
175 Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.
176 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
177 Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells. J Gen Virol. 2010 Aug;91(Pt 8):1959-1970. doi: 10.1099/vir.0.020065-0. Epub 2010 Apr 14.
178 CYP4F2 genetic variant alters required warfarin dose. Blood. 2008 Apr 15;111(8):4106-12. doi: 10.1182/blood-2007-11-122010. Epub 2008 Feb 4.
179 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
180 CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes. Toxicol In Vitro. 2017 Apr;40:124-133.
181 Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells. Int J Biomed Sci. 2013 Mar;9(1):18-25.
182 Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
183 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
184 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
185 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
186 Antidepressant drugs activate SREBP and up-regulate cholesterol and fatty acid biosynthesis in human glial cells. Neurosci Lett. 2006 Mar 13;395(3):185-90. doi: 10.1016/j.neulet.2005.10.096. Epub 2005 Dec 1.
187 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
188 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
189 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
190 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
191 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
192 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
193 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
194 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
195 Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
196 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
197 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
198 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
199 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
200 DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
201 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
202 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
203 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
204 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
205 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
206 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
207 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
208 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
209 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
210 Comparative Analysis of Transcriptomic Changes including mRNA and microRNA Expression Induced by the Xenoestrogens Zearalenone and Bisphenol A in Human Ovarian Cells. Toxins (Basel). 2023 Feb 9;15(2):140. doi: 10.3390/toxins15020140.
211 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
212 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
213 Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
214 BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25.
215 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
216 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
217 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
218 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
219 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
220 Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells. Mutat Res. 2011 Sep 18;724(1-2):76-85. doi: 10.1016/j.mrgentox.2011.06.003. Epub 2011 Jun 17.
221 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
222 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
223 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
224 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
225 Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide. Environ Mol Mutagen. 2015 Jun;56(5):477-90. doi: 10.1002/em.21937. Epub 2015 Apr 14.
226 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
227 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
228 Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
229 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
230 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
231 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
232 Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
233 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
234 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
235 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
236 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
237 Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
238 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
239 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
240 Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
241 Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
242 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
243 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
244 Label-free quantitative proteomic analysis identifies the oncogenic role of FOXA1 in BaP-transformed 16HBE cells. Toxicol Appl Pharmacol. 2020 Sep 15;403:115160. doi: 10.1016/j.taap.2020.115160. Epub 2020 Jul 25.
245 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
246 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
247 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
248 Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
249 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
250 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
251 Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2015 Feb 3;328:102-11. doi: 10.1016/j.tox.2014.12.018. Epub 2014 Dec 18.
252 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
253 Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
254 Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
255 Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells. Food Chem Toxicol. 2017 Nov;109(Pt 1):253-263. doi: 10.1016/j.fct.2017.09.004. Epub 2017 Sep 4.
256 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
257 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
258 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
259 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
260 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
261 Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
262 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
263 Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro. Oncotarget. 2014 Dec 30;5(24):12891-907.
264 Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
265 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
266 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.