Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMK7HFI)

Drug Name
Mefenamic acid Drug Info
Synonyms
ApoMefenamic; Bonabol; Contraflam; Coslan; Dysman; Lysalgo; Mefac; Mefacit; Mefedolo; Mefenacid;Mefenamate; Mefenaminsaeure; Mefic; Mycasaal; Namphen; NuMefenamic; Parkemed; Pinalgesic; Ponalar; Ponalgic; Ponmel; Ponstan; Ponstel; Ponstil; Ponstyl; Ponsyl; Pontal; Rolan; Tanston; Vialidon; APS Brand of Mefenamic Acid; Acide mefenamique; Acide mefenamique [French]; Acido mefenamico; Acidum mefenamicum; Antigen Brand of Mefenamic Acid; Apo Mefenamic; Apotex Brand of Mefenamic Acid; Ashbourne Brand of Mefenamic Acid; Chemidex Brand of Mefenamic Acid; Clonmel Brand of Mefenamic Acid; Elan Brand of Mefenamic Acid; Farmasierra Brand of Mefenamic Acid; First Horizon Brand of Mefenamic Acid; Godecke Brand of Mefenamic Acid; Mefanamic acid; Mefenaminic Acid; Mefenaminsaeure [German]; Mephenamic acid; Mephenaminic acid; Methenamic acid; Nu Mefenamic; Nu Pharm Brand of Mefenamic Acid; PMS Mefenamic Acid; Parke Davis Brand of Mefenamic Acid; Pfizer Brand of Mefenamic Acid; Pharmascience Brand of Mefenamic Acid; Pinewood Brand of Mefenamic Acid; Ponstan forte; Rowa Brand of Mefenamic Acid; Tamany Bonsan; Warner Lambert Brand of Mefenamic Acid; CL 473; CN 35355; HL 1; ID8; INF 3355; M1782; AGN-1255; Ac. mefenamico; Ac. mefenamico [Italian]; Acid, Mefenamic; Acid, Mefenaminic; Acide mefenamique [INN-French]; Acido mefenamico [INN-Spanish]; Acidum mefenamicum [INN-Latin]; Apo-Mefenamic; Bafameritin-M; Bafhameritin-M; CN-35355; Dyfenamic (TN); F0850-6853; Forte, Ponstan; INF-3355; In-M; Mafepain (TN); Meftal (TN); Mephadolor (TN); Nu-Mefenamic; Nu-Pharm Brand of Mefenamic Acid; PMS-Mefenamic Acid; Parkemed (TN); Ponstal (TN); Ponstan (TN); Ponstel (TN); Potarlon (TN); Warner-Lambert Brand of Mefenamic Acid; Mefenamic acid (JP15/USP/INN); Mefenamic acid [USAN:INN:BAN:JAN]; N-2,3-Xylylanthranilic acid; N-(2,3-Dimethylphenyl)anthranilic acid; N-(2,3-Xylyl)anthranilic acid; N-(2,3-Xylyl)-2-aminobenzoic acid; 2-((2,3-Dimethylphenyl)amino)benzoic acid; 2-(2,3-Dimethylanilino)benzoic acid; 2-(2,3-Xylidino)benzoic Acid; 2-(2,3-dimethylphenylamino)benzoic acid; 2-[(2,3-dimethylphenyl)amino]benzoic acid
Indication
Disease Entry ICD 11 Status REF
Dysmenorrhea GA34.3 Approved [1]
Pain MG30-MG3Z Approved [2]
Therapeutic Class
Antiinflammatory Agents
Cross-matching ID
PubChem CID
4044
ChEBI ID
CHEBI:6717
CAS Number
CAS 61-68-7
TTD Drug ID
DMK7HFI
VARIDT Drug ID
DR00533
INTEDE Drug ID
DR1014
ACDINA Drug ID
D00390

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [11]
Naproxen DMZ5RGV Bursitis Approved [12]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [13]
Indomethacin DMSC4A7 Bursitis Approved [14]
Celecoxib DM6LOQU Dysmenorrhea GA34.3 Approved [15]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [16]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [17]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [18]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [19]
Aminosalicylic Acid DMENSL5 Crohn disease DD70 Approved [14]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [20]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [5]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [5]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [22]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [23]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [24]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [5]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [25]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [26]
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Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [27]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [28]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [29]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [21]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [30]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [21]
Verapamil DMA7PEW Angina pectoris BA40 Approved [31]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [32]
Estrone DM5T6US Acne vulgaris ED80 Approved [33]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [34]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [39]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [40]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [41]
Capsaicin DMGMF6V Back pain ME84.Z Approved [42]
Zafirlukast DMHNQOG Asthma CA23 Approved [43]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [40]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [44]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [41]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
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Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [35]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [6]
Propranolol DM79NTF Angina pectoris BA40 Approved [36]
Dextromethorphan DMUDJZM Allergic rhinitis CA08.0 Approved [35]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [37]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [37]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [35]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [35]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [6]
GEA-6414 DM8J0MK N. A. N. A. Phase 1/2 [6]
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Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [45]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [46]
Trospium chloride DM32XZT Discovery agent N.A. Approved [47]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [48]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [49]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [53]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [50]
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Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [50]
Succinic acid DMDWICP Malnutrition 5B50-5B71 Approved [56]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [57]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [50]
Ketoprofen DMRKXPT Bursitis Approved [50]
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Drug(s) Affected By Organic anion transporter 7 (SLC22A9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [60]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [50]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [51]
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Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [50]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [50]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [51]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [63]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [64]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [65]
Ketoprofen DMRKXPT Bursitis Approved [50]
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Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [59]
Paclitaxel DMLB81S Breast carcinoma Approved [67]
Allopurinol DMLPAOB Gout FA25 Approved [67]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [67]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [67]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [67]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [67]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [68]
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Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [69]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [9]
Diazepam DM08E9O Alcohol withdrawal Approved [70]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [71]
Desogestrel DM27U4Y Contraception QA21 Approved [71]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [72]
Quercetin DM3NC4M Obesity 5B81 Approved [73]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [9]
Diazepam DM08E9O Alcohol withdrawal Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [76]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [9]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [77]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [9]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [78]
Testosterone DM7HUNW Hot flushes GA30 Approved [79]
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Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [80]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [9]
Diazepam DM08E9O Alcohol withdrawal Approved [70]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [81]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [9]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [9]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [82]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [83]
Ethacrynic acid DM60QMR Edema MG29 Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [9]
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Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [84]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [85]
Minoxidil DMA2Z4F Alopecia ED70 Approved [86]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [87]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [86]
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [88]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [89]
Methotrexate DM2TEOL Anterior urethra cancer Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [91]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [91]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [92]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [93]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [94]
Etidronic acid DM1XHYJ Bone Paget disease Approved [91]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [91]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [91]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [95]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [96]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [97]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Gefitinib DM15F0X Colon adenocarcinoma Approved [99]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [100]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [101]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [100]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [102]
Selenium DM25CGV N. A. N. A. Approved [103]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [104]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [105]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [106]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [107]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [108]
Diazepam DM08E9O Alcohol withdrawal Approved [109]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [110]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [111]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [112]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [113]
Methotrexate DM2TEOL Anterior urethra cancer Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [115]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [116]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [117]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [118]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [119]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [121]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [102]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [122]
Methotrexate DM2TEOL Anterior urethra cancer Approved [116]
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Drug(s) Affected By L-selectin (SELL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [123]
Meloxicam DM2AR7L Arthritis FA20 Approved [123]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [125]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [126]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [123]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [127]
Nabumetone DMAT2XH Osteoarthritis FA00-FA05 Approved [123]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
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Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [128]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [130]
Testosterone DM7HUNW Hot flushes GA30 Approved [131]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [7]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [131]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [7]
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Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [133]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [134]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [136]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [134]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [134]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [134]
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Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [10]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [75]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [137]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [138]
Estrone DM5T6US Acne vulgaris ED80 Approved [139]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [140]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [141]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [142]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [143]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [119]
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Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [144]
Quercetin DM3NC4M Obesity 5B81 Approved [58]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [144]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [145]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [144]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [144]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [146]
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Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [147]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [148]
Thiotepa DMIZKOP Breast cancer 2C60-2C65 Approved [149]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [151]
Ethacrynic acid DM60QMR Edema MG29 Approved [152]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [153]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [154]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [66]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [156]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [10]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [157]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [158]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [159]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Ethacrynic acid DM60QMR Edema MG29 Approved [81]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [161]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [162]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [163]
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Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [164]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [41]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [165]
Capsaicin DMGMF6V Back pain ME84.Z Approved [42]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [40]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [166]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [164]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [129]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [146]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [168]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [132]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [169]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [170]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [171]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [172]
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Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [173]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [173]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [173]
Capsaicin DMGMF6V Back pain ME84.Z Approved [42]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [174]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [166]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [175]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [176]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [177]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [178]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [179]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [180]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [180]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [181]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Selenium DM25CGV N. A. N. A. Approved [184]
Etretinate DM2CZFA Keratosis ED56 Approved [185]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [187]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [38]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [188]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [41]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [40]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [40]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [189]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [190]
Capsaicin DMGMF6V Back pain ME84.Z Approved [191]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [178]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [193]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [194]
Ethanol DMDRQZU Chronic pain MG30 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [136]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [136]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [196]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [197]
Testosterone DM7HUNW Hot flushes GA30 Approved [131]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [131]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [198]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [199]
Methotrexate DM2TEOL Anterior urethra cancer Approved [124]
Leflunomide DMR8ONJ Arthritis FA20 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [201]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [202]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [203]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [155]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [204]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [205]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Prostaglandin G/H synthase 2 (COX-2) TTVKILB PGH2_HUMAN Inhibitor [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 2C9 (CYP2C9) Main DME DE5IED8 CP2C9_HUMAN Substrate [4]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [5]
Cytochrome P450 102A1 (cyp102) DE4OGUF CPXB_BACMB Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
15-hydroxyprostaglandin dehydrogenase (HPGD) OTYZI6JB PGDH_HUMAN Gene/Protein Processing [7]
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [8]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Gene/Protein Processing [9]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Gene/Protein Processing [9]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Gene/Protein Processing [9]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Biotransformations [4]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Biotransformations [4]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [10]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Biotransformations [4]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Biotransformations [4]

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