Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWAF5Z)

• Drug Name: MANGIFERIN Drug Info
• Synonyms: Mangiferin; 4773-96-0; Hedysarid; Chinomin; Alpizarin; Chinonin; Aphloiol; Alpizarine; UNII-1M84LD0UMD; 1M84LD0UMD; CHEBI:6682; 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one; (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-2-yl)-D-glucitol; 1,3,6,7-Tetrahydroxyxanthone-C2-b-D-glucoside; Chinoinin; 9H-Xanthen-9-one, 2-.beta.-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; C19H18O11; NSC 248870; 9H-Xanthen-9-one, 2-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; cid_5358385; Mangiferin;; Alpizarine;; Chinomin

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281647
  ChEBI ID: CHEBI:6682
  CAS Number: CAS 4773-96-0
  TTD Drug ID: DMWAF5Z

Molecule-Related Drug Atlas

Drug(s) Targeting Aldose reductase (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epalrestat	DM5OGK0	Diabetic neuropathy	8C0Z	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[13]
Fidarestat	DMZL1I8	Diabetic complication	5A2Y	Phase 3	[14]
Ranirestat	DMD5QRS	Diabetic neuropathy	8C0Z	Phase 3	[15]
CONTIGOSIDE B	DMX9V8K	Thrombosis	DB61-GB90	Phase 2/3	[16]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[15]
BNV-222	DMYFQJL	Diabetic neuropathy	8C0Z	Phase 2/3	[17]
LIDORESTAT	DMA0RI9	Diabetic complication	5A2Y	Phase 2	[18]
QR-333	DMKVIWM	Diabetic neuropathy	8C0Z	Phase 2	[19]
ADMVA	DM819CO	Diabetic complication	5A2Y	Phase 2	[15]

Drug(s) Targeting Influenza Neuraminidase (Influ NA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Oseltamivir	DMGO72P	Influenza	1E30-1E32	Approved	[20]
Zanamivir	DMFMBZ4	Influenza	1E30-1E32	Approved	[20]
Peramivir	DMNXY5K	Influenza virus infection	1E30-1E32	Approved	[21]
UX-001	DMD2O0L	Hereditary inclusion body myositis	4A41.2	Phase 3	[22]
CS-8958	DM4CSDH	Influenza virus infection	1E30-1E32	Phase 3	[21]
DAS-181	DM0Y8JP	Influenza virus infection	1E30-1E32	Phase 2	[23]
Lactose	DMO4GPK	Discovery agent	N.A.	Phase 1	[22]
GS-3435	DMV7JC6	Influenza virus infection	1E30-1E32	Terminated	[24]
BCX-140	DMBJERO	Influenza virus infection	1E30-1E32	Terminated	[25]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[22]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Haloperidol	DM96SE0	Delirium		Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[30]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[31]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[39]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[40]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[41]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[42]
Methyltestosterone	DMWLFGO	Advanced cancer	2A00-2F9Z	Approved	[40]
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[40]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[43]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[44]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[45]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[50]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[51]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[52]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[53]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[53]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[54]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[55]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[56]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[57]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[58]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[59]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[28]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[60]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[63]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[65]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[66]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[67]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[68]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[70]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[73]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[74]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[54]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[64]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[75]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[76]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[77]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[78]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[82]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[84]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[85]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[86]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[64]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[63]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[54]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[88]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[64]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[89]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[63]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[64]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Selenium	DM25CGV	N. A.	N. A.	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[98]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[102]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[105]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[108]

Drug(s) Affected By Period circadian protein homolog 1 (PER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Haloperidol	DM96SE0	Delirium		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[112]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[113]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[114]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[115]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[133]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[134]

Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[28]
Anagrelide	DMSQ8MD	Thrombocythemia	3B63	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[124]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[140]

Drug(s) Affected By Coagulation factor X (F10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[141]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[142]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[145]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[146]

Drug(s) Affected By Beta-nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[148]
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[154]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[155]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[156]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[157]
Fructose	DM43AN2	Vomiting	MD90	Approved	[28]
Ketoprofen	DMRKXPT	Bursitis		Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[159]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[160]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[118]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[28]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[164]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[165]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[167]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[168]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[174]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[28]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[182]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[183]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[182]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[184]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[185]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[186]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[187]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[188]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[189]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[190]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[191]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[192]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[190]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[198]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[199]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[119]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[202]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[206]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]

Drug(s) Affected By Phospholipase A2, membrane associated (PLA2G2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[207]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[194]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[122]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[210]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[174]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[103]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[214]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[216]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[217]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[223]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[226]
Fructose	DM43AN2	Vomiting	MD90	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[228]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[229]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[230]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[231]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[232]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[159]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[236]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[237]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[239]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[240]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[241]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[243]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[244]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[245]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[246]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[247]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[251]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[253]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[262]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[266]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[268]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[248]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[280]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[282]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[283]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aldose reductase (AKR1B1)	TTFBNVI	ALDR_HUMAN	Inhibitor	[2]
Influenza Neuraminidase (Influ NA)	TT50QJ3	NRAM_I33A0	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Gene/Protein Processing	[3]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[4]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[7]
Beta-nerve growth factor (NGF)	OTOLABJT	NGF_HUMAN	Protein Interaction/Cellular Processes	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[9]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[7]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[10]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[11]

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