Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQ8FR2)

• Drug Name: Prednisolone Drug Info
• Synonyms: Nanocort; Prednisolone (injectable liposome formulation, rheumatoid arthritis); Prednisolone (injectable liposome formulation, rheumatoid arthritis), Enceladus; Prednisolone (injectable liposome formulation, rheumatoid arthritis), Galapagos

Indication

Disease Entry	ICD 11	Status	REF
Acute adrenal insufficiency		Approved	[1]
Acute asthma	CA23	Approved	[1]
Addison disease	5A74.0	Approved	[1]
Allergic rhinitis	CA08.0	Approved	[1]
Angioedema	4A00.15	Approved	[1]
Aspiration pneumonitis		Approved	[1]
Autoimmune haemolytic anaemia	3A20	Approved	[1]
Blepharoconjunctivitis		Approved	[1]
Bursitis		Approved	[1]
Cerebral edema	8D60.1	Approved	[1]
Chronic graft versus host disease		Approved	[1]
Congenital adrenal hyperplasia	5A71.01	Approved	[1]
Corneal abrasion	NA06.4	Approved	[1]
Corneal ulcer	9A76	Approved	[1]
Crohn disease	DD70	Approved	[1]
Dacryocystitis		Approved	[1]
Demodex blepharitis	1G07	Approved	[1]
Dermatitis herpetiformis	EB44	Approved	[1]
Diamond-Blackfan anemia		Approved	[1]
Disorder of orbital region		Approved	[1]
Epicondylitis		Approved	[1]
Erythema multiforme		Approved	[1]
Exanthem		Approved	[1]
Fever	MG26	Approved	[1]
Granuloma annulare		Approved	[1]
Hypersensitivity pneumonitis		Approved	[1]
Inflammatory bowel disease	DD72	Approved	[1]
Ischemia-reperfusion injury	DB98.B	Approved	[1]
Keratitis		Approved	[1]
Leukemia		Approved	[1]
Lupus nephritis	4A40.0Y	Approved	[1]
Microscopic polyangiitis		Approved	[1]
Miliary tuberculosis		Approved	[1]
Mycosis fungoides	2B01	Approved	[1]
Myeloproliferative neoplasm	2A20	Approved	[1]
Pneumocystis pneumonia	CA40.20	Approved	[1]
Polymyalgia rheumatica		Approved	[1]
Primary cutaneous T-cell lymphoma		Approved	[1]
Psoriasis	EA90	Approved	[1]
Psoriatic arthritis	FA21	Approved	[1]
Rheumatic heart disease		Approved	[1]
Rosacea	ED90.0	Approved	[1]
Sarcoidosis	4B20.5	Approved	[1]
Serum sickness		Approved	[1]
Severe asthma	CA23	Approved	[1]
Skin disease	EA00-EM0Z	Approved	[1]
Solid tumour/cancer	2A00-2F9Z	Approved	[2]
Sympathetic ophthalmia		Approved	[1]
Systemic lupus erythematosus	4A40.0	Approved	[1]
Ulcerative colitis	DD71	Approved	[1]
Multiple sclerosis	8A40	Phase 3	[3]
Acquired thrombocytopenia		Investigative	[1]
Asthma	CA23	Investigative	[1]
Beta-thalassemia major		Investigative	[1]
Classic Hodgkin lymphoma		Investigative	[1]
Follicular lymphoma	2A80	Investigative	[1]
Iridocyclitis		Investigative	[1]
Sjogren syndrome	4A43.20	Investigative	[1]
Synovitis		Investigative	[1]
Uveitis	9A96.Z	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 5755
  ChEBI ID: CHEBI:8378
  CAS Number: CAS 50-24-8
  TTD Drug ID: DMQ8FR2
  VARIDT Drug ID: DR00428
  INTEDE Drug ID: DR1332
  ACDINA Drug ID: D00551

Molecule-Related Drug Atlas

Drug(s) Targeting Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[11]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[12]
Fluticasone	DMGCSVF	Allergic rhinitis	CA08.0	Approved	[13]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[12]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[12]
Deflazacort	DMV0RNS	Duchenne dystrophy	8C70	Approved	[12]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[14]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[15]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[16]
Fluocinolone Acetonide	DMG2KI4	Choroiditis		Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[175]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[20]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[23]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[45]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[46]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[47]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[48]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[49]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[50]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[34]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[41]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[36]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Affected By Calmegin (CLGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[76]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[79]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[80]

Drug(s) Affected By Gasdermin-E (GSDME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[88]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[85]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[93]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[94]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]

Drug(s) Affected By Antiviral innate immune response receptor RIG-I (RIGI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[104]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[106]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[109]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[110]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[111]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[116]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[119]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[71]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[128]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[132]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[137]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[143]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[144]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[145]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[150]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[148]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By Neuromedin-B (NMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[64]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Haloperidol	DM96SE0	Delirium		Approved	[153]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[137]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[155]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[164]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]

Drug(s) Affected By C-X-C motif chemokine 3 (CXCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[169]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[175]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[174]

Drug(s) Affected By Adenosine receptor A2a (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[180]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[181]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[139]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[186]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[187]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[188]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[190]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[191]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[192]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]

Drug(s) Affected By Prolargin (PRELP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[197]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[198]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[199]

Drug(s) Affected By Spermine synthase (SMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[202]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[203]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[205]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[208]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[89]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[214]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[119]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[215]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[217]

Drug(s) Affected By Neuronal membrane glycoprotein M6-b (GPM6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[219]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[221]

Drug(s) Affected By Nidogen-2 (NID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[223]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[224]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[225]

Drug(s) Affected By 2'-5'-oligoadenylate synthase-like protein (OASL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[226]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[174]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[228]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[229]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[230]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]

Drug(s) Affected By Lymphocyte antigen 6E (LY6E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[98]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Olfactomedin-like protein 2B (OLFML2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[232]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[81]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[235]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19B (RNF19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[236]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By Amphoterin-induced protein 2 (AMIGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[195]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[237]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC6 (HERC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[238]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]

Drug(s) Affected By Equilibrative nucleobase transporter 1 (SLC43A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Bortezomib	DMNO38U	Leukemia		Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[241]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[242]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[171]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Bortezomib	DMNO38U	Leukemia		Approved	[240]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[178]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[243]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[246]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[247]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[223]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[174]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[174]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]

Drug(s) Affected By Anthrax toxin receptor 1 (ANTXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[195]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[254]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[240]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Bortezomib	DMNO38U	Leukemia		Approved	[255]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[257]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[258]

Drug(s) Affected By Large neutral amino acids transporter small subunit 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[260]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[8]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[8]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[261]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]

Drug(s) Affected By Paired immunoglobulin-like type 2 receptor alpha (PILRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[180]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[223]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[8]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[8]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[263]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[264]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[265]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[268]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[146]

Drug(s) Affected By Cytochrome P450 2S1 (CYP2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[270]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[270]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[271]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[271]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]

Drug(s) Affected By Inactive phospholipase C-like protein 1 (PLCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[272]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[273]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[264]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[268]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[274]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[277]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[274]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By Protein FAM200C (FAM200C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[278]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[279]

Drug(s) Affected By Arrestin domain-containing protein 3 (ARRDC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[280]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]

Drug(s) Affected By Cysteine-rich motor neuron 1 protein (CRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[201]

Drug(s) Affected By SLAM family member 5 (CD84)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[268]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[283]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[284]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[285]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[268]

Drug(s) Affected By PDZ and LIM domain protein 1 (PDLIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[78]

Drug(s) Affected By Basic helix-loop-helix ARNT-like protein 1 (BMAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[287]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[240]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[288]

Drug(s) Affected By Period circadian protein homolog 2 (PER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[238]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[288]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]

Drug(s) Affected By Period circadian protein homolog 1 (PER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Haloperidol	DM96SE0	Delirium		Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[287]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[290]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[291]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[294]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[104]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[298]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[299]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[300]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[302]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[303]
Fructose	DM43AN2	Vomiting	MD90	Approved	[104]
Ketoprofen	DMRKXPT	Bursitis		Approved	[104]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[305]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[306]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[307]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[309]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[132]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[311]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[312]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[292]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[104]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[313]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[314]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[315]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[316]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[317]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[197]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[324]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[325]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[326]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[331]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[332]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[333]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[298]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[334]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[335]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[336]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[337]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[339]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[340]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[334]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[335]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[343]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[345]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[346]

Drug(s) Affected By Mineralocorticoid receptor (NR3C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[347]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[348]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[349]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[350]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[349]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[349]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[351]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[352]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[353]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[354]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[128]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[355]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[310]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[356]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[146]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[357]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[359]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[360]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[360]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[129]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[357]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[359]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[361]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[360]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[131]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[298]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[161]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[365]

Drug(s) Affected By Ganglioside GM2 activator (GM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[366]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[367]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[273]

Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[368]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[369]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[370]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[95]

Drug(s) Affected By C-X-C chemokine receptor type 2 (CXCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[372]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[373]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[233]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[374]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[375]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[55]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[377]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]

Drug(s) Affected By Growth/differentiation factor 5 (GDF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[291]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[233]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[378]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[223]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[379]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[380]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[381]

Drug(s) Affected By D site-binding protein (DBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[382]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[263]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[384]

Drug(s) Affected By Cryptochrome-1 (CRY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Haloperidol	DM96SE0	Delirium		Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[287]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[273]

Drug(s) Affected By Mucin-16 (MUC16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[252]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[386]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[387]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[234]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[388]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[389]

Drug(s) Affected By Lymphocyte antigen 96 (LY96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[53]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[391]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[392]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[173]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[393]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[394]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[395]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[290]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[70]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[397]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[399]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[400]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[401]

Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[402]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[403]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[197]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[404]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[405]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[407]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[410]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[411]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[412]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glucocorticoid receptor (NR3C1)	TTYRL6O	GCR_HUMAN	Modulator	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[8]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Regulation of Drug Effects	[9]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[8]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Gene/Protein Processing	[8]
Adenosine receptor A2a (ADORA2A)	OTVRBZ0I	AA2AR_HUMAN	Gene/Protein Processing	[8]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[10]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Gene/Protein Processing	[8]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Gene/Protein Processing	[8]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Gene/Protein Processing	[8]
Antiviral innate immune response receptor RIG-I (RIGI)	OTFIIC43	RIGI_HUMAN	Gene/Protein Processing	[8]

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