Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNXDGQ)

• Drug Name: NSC-1771 Drug Info
• Synonyms: Thiram

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5455
  ChEBI ID: CHEBI:9495
  CAS Number: CAS 137-26-8
  TTD Drug ID: DMNXDGQ
  INTEDE Drug ID: DR1585

Molecule-Related Drug Atlas

Drug(s) Targeting Janus kinase 2 (JAK-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[11]
Baricitinib	DM4ONW5	Rheumatoid arthritis	FA20	Approved	[12]
Ruxolitinib	DM7Q98D	Essential thrombocythemia	3B63.1Z	Approved	[13]
Pacritinib	DM1T6ZN	Myelofibrosis	2A20.2	Approved	[14]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[15]
ITF2357	DMFZBNE	Duchenne dystrophy	8C70	Phase 3	[16]
XL019	DMJ6F5C	Solid tumour/cancer	2A00-2F9Z	Phase 3	[16]
Cerdulatinib	DMSCR2H	B-cell lymphoma	2A86	Phase 2	[17]
CTP-543	DM3SYOK	Alopecia	ED70	Phase 2	[18]
INCB039110	DMD9RV3	Malignant neoplasm	2A00-2F9Z	Phase 2	[19]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[24]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[26]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[27]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[28]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[29]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[32]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[33]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[34]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[35]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[36]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[37]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[39]

Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[45]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[46]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[47]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[48]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[56]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[56]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[61]
Bortezomib	DMNO38U	Leukemia		Approved	[62]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[67]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[72]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[67]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[74]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[76]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[80]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[81]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[91]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[86]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[95]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[56]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[99]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[102]
Selenium	DM25CGV	N. A.	N. A.	Approved	[103]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[104]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[110]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[113]

Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[119]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[121]

Drug(s) Affected By AMP deaminase 3 (AMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[117]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[123]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[125]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[87]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[134]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[135]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[49]

Drug(s) Affected By Nesprin-2 (SYNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[123]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[38]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[150]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[151]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[152]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[154]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[155]
Fructose	DM43AN2	Vomiting	MD90	Approved	[147]
Ketoprofen	DMRKXPT	Bursitis		Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[158]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[159]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[38]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[38]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[166]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[38]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[168]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[169]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[170]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[171]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[172]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[173]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[174]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[175]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[177]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[178]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[179]

Drug(s) Affected By Arginase-1 (ARG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[182]

Drug(s) Affected By Protein kinase C gamma type (PRKCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[184]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[121]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[185]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[187]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[188]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[188]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[189]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[190]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[193]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[194]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[104]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[195]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[201]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[202]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[99]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[204]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[101]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[205]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[38]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[208]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[210]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[211]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[212]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[4]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[213]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[214]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[219]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[220]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[221]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[225]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[228]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[206]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[233]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[238]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[163]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[240]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[242]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[243]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[245]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[242]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[248]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[249]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[250]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[252]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[253]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[254]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[255]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[256]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[257]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[258]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[257]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[253]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[147]

Drug(s) Affected By Glucose-6-phosphatase catalytic subunit 1 (G6PC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[259]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[260]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[262]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[232]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[232]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[211]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[263]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[264]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[265]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[267]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[52]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[206]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[270]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[271]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[273]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[275]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[276]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[277]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[278]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[200]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[226]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[198]
Indomethacin	DMSC4A7	Bursitis		Approved	[279]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[281]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[206]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[282]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[283]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[284]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[285]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[286]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[287]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[288]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[290]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[292]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[293]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[294]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[293]

Drug(s) Affected By Parkinson disease protein 7 (PARK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[287]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[90]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[297]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[298]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[299]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[300]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[301]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[302]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[164]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[145]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[270]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[303]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[98]

Drug(s) Affected By Annexin A10 (ANXA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[44]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[209]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[305]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Janus kinase 2 (JAK-2)	TTRMX3V	JAK2_HUMAN	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2E1 (CYP2E1) Main DME	DEVDYN7	CP2E1_HUMAN	Substrate	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[3]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[5]
AMP deaminase 3 (AMPD3)	OT5SP1KJ	AMPD3_HUMAN	Gene/Protein Processing	[6]
Annexin A10 (ANXA10)	OTA8LWSL	ANX10_HUMAN	Gene/Protein Processing	[7]
Arginase-1 (ARG1)	OTHZITAM	ARGI1_HUMAN	Gene/Protein Processing	[7]
C-C chemokine receptor type 2 (CCR2)	OTQ7T10J	CCR2_HUMAN	Gene/Protein Processing	[8]
cAMP-responsive element modulator (CREM)	OTJIJ5AL	CREM_HUMAN	Gene/Protein Processing	[8]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Gene/Protein Processing	[9]
Cyclic AMP-responsive element-binding protein 1 (CREB1)	OT1MDLA1	CREB1_HUMAN	Gene/Protein Processing	[10]

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