Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMRC3OZ)

• Drug Name: methylglyoxal Drug Info
• Synonyms: pyruvaldehyde; pyruvic aldehyde; 2-Oxopropanal; acetylformaldehyde; 78-98-8; Acetylformyl; Propanal, 2-oxo-; 2-Ketopropionaldehyde; Propanedione; Propanolone; Pyroracemic aldehyde; Glyoxal, methyl; 2-Oxopropionaldehyde; alpha-Ketopropionaldehyde; 1-Ketopropionaldehyde; Propionaldehyde, 2-keto; Propionaldehyde, 2-oxo-; 1,2-Propanedione; Acetalformaldehyde; alpha-Ketopropionic aldehyde; 2-oxo-Propionaldehyde; CH3COCHO; FEMA No 2969; CCRIS 1741; 2-oxo-propanal; NSC 79019; NSC 626580; Pyruvoyl Group

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 880
  ChEBI ID: CHEBI:17158
  CAS Number: CAS 78-98-8
  TTD Drug ID: DMRC3OZ

Molecule-Related Drug Atlas

Drug(s) Targeting Phospholipase A2 (PLA2G1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[1]
Miltefosine	DMND304	Chronic urticaria		Approved	[10]
Clocortolone	DM9ZMQH	Exanthem		Approved	[11]
Clobetasol	DMUXP52	Rosacea	ED90.0	Approved	[12]
Diflorasone	DMI9PRJ	Exanthem		Approved	[13]
AllerB	DM78DOT	Allergy	4A80-4A85	Phase 2b	[14]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[15]
MANOALIDE	DMB4A8I	Arthritis	FA20	Phase 2	[16]
MRX-4	DMQZWYE	Allergic rhinitis	CA08.0	Phase 2	[17]
MRX-6	DMLVQKF	Contact dermatitis	EK0Z	Phase 2	[18]

Drug(s) Targeting Transformation-sensitive protein p120 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[19]
LY3526318	DMFXNQM	Chronic low-back pain	MG30	Phase 2	[20]
HX-100	DMFRM15	Diabetic neuropathy	8C0Z	Phase 1	[21]
NPPB	DMFIWAN	Discovery agent	N.A.	Investigative	[22]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[23]
[3H]resolvin D1	DMFT0HU	Discovery agent	N.A.	Investigative	[24]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[25]
icilin	DMYVOL9	Discovery agent	N.A.	Investigative	[26]
4-oxo-nonenal	DMPX1J9	Discovery agent	N.A.	Investigative	[27]
dibutyl phthalate	DMEDGKO	Discovery agent	N.A.	Investigative	[28]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[29]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[30]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[31]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[32]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[37]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[29]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[47]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[48]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[52]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[53]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[57]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[59]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[60]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[61]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[61]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[59]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[59]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[65]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[68]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[70]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[73]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[74]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]
Haloperidol	DM96SE0	Delirium		Approved	[76]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[78]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[55]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[65]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[92]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[68]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[95]

Drug(s) Affected By Lactoylglutathione lyase (GLO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]

Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[106]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[107]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[108]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[109]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[109]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[111]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[113]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[116]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[118]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[119]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[66]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[121]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[126]

Drug(s) Affected By Ferroptosis suppressor protein 1 (AIFM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[130]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[48]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[48]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[131]
Bortezomib	DMNO38U	Leukemia		Approved	[132]

Drug(s) Affected By Ceruloplasmin (CP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[117]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[76]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[138]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[139]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[140]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[141]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[145]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[156]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[154]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[157]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[157]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[158]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[160]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[164]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[170]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[171]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[172]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[173]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[174]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[176]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[177]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[179]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[182]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[183]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[160]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Selenium	DM25CGV	N. A.	N. A.	Approved	[184]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[185]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[190]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[191]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[74]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[191]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[194]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[195]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[196]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[197]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[160]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[198]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[162]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[200]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[199]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[35]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[217]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[219]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[220]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[227]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[228]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[229]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[230]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[231]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]

Drug(s) Affected By Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[235]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[237]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[242]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[243]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[244]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[247]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[248]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[249]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[241]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[251]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[95]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[256]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[141]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[257]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[260]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[261]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[262]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[264]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[266]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[66]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[83]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[271]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[272]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[269]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[273]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[278]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[279]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[280]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[282]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[283]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[284]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[285]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[67]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[93]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[190]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[287]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[288]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[289]

Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[294]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[295]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[100]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[298]

Drug(s) Affected By Aldo-keto reductase family 1 member A1 (AKR1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[299]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[45]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[299]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[300]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phospholipase A2 (PLA2G1B)	TT9V5JH	PA21B_HUMAN	Inhibitor	[1]
Transformation-sensitive protein p120 (TRPA1)	TTELV3W	TRPA1_HUMAN	Activator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Hydroxyacylglutathione hydrolase (HAGH) Main DME	DE05IKP	GLO2_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Gene/Protein Processing	[4]
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)	OTGEDDM2	ARK72_HUMAN	Gene/Protein Processing	[5]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Post-Translational Modifications	[6]
Aldo-keto reductase family 1 member A1 (AKR1A1)	OTZT9NOW	AK1A1_HUMAN	Biotransformations	[7]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Biotransformations	[7]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[8]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[4]
BDNF/NT-3 growth factors receptor (NTRK2)	OTD557PU	NTRK2_HUMAN	Gene/Protein Processing	[9]

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