Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMT5GNL)

Drug Name
Romidepsin Drug Info
Synonyms
Chromadax; Istodax; Antibiotic FR 901228; FK 228; FK228; FR 901228; FR901228; HDInhib_000006; Chromadax (TN); FK-228; FK-901228; FR-901228; Istodax (TN); Romidepsin (USAN); Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (35)-disulfide; L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide; (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone; (1S,4S,7Z,10S,16E,21R)-7-ethylidene-4,21-di(propan-2-yl)-2-oxa-12,13-dithia-5,8,20,23-tetrazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentone
Indication
Disease Entry ICD 11 Status REF
Cutaneous T-cell lymphoma 2B01 Approved [1]
Gastrin-producing neuroendocrine tumor Approved [2]
Glucagonoma Approved [2]
Insulinoma 2C10.1 Approved [2]
Lung carcinoid tumor Approved [2]
Melanoma 2C30 Approved [2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified Approved [2]
Primary cutaneous T-cell lymphoma Approved [2]
Urethral cancer 2C93 Approved [2]
Peripheral T-cell lymphoma 2A90.C Phase 3 [3]
Renal cell carcinoma 2C90 Phase 3 [1]
Cross-matching ID
PubChem CID
5352062
ChEBI ID
CHEBI:61080
CAS Number
CAS 128517-07-7
TTD Drug ID
DMT5GNL
VARIDT Drug ID
DR00233
INTEDE Drug ID
DR1438
ACDINA Drug ID
D01401

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Histone deacetylase 1 (HDAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [17]
Panobinostat DM58WKG Chronic graft versus host disease Approved [17]
HBI-8000 DMDWYUN Non-small-cell lung cancer 2C25.Y Registered [18]
ITF2357 DMFZBNE Duchenne dystrophy 8C70 Phase 3 [19]
NVP-LAQ824 DM8JWNA Mood disorder 6A60-6E23 Phase 3 [20]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [21]
Phenylbutyrate DMBHPDW Urea cycle disorder 5C50.A Phase 2 [22]
MGCD-0103 DM726HX Non-small-cell lung cancer 2C25.Y Phase 2 [17]
Resminostat DMNE1FR Hepatocellular carcinoma 2C12.02 Phase 2 [23]
Sodium butyrate DMKNIVG Acute myeloid leukaemia 2A60 Phase 2 [24]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [25]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [26]
Methotrexate DM2TEOL Anterior urethra cancer Approved [27]
Folic Acid DMEMBJC Colorectal carcinoma Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [27]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [29]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [27]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [31]
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Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [33]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [34]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [35]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [33]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [36]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [37]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [38]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [39]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [38]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [40]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [41]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [45]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [46]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [47]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [41]
Verapamil DMA7PEW Angina pectoris BA40 Approved [48]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [50]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [51]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [53]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [54]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [56]
Verapamil DMA7PEW Angina pectoris BA40 Approved [57]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [52]
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Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [58]
Verapamil DMA7PEW Angina pectoris BA40 Approved [59]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [60]
Estrone DM5T6US Acne vulgaris ED80 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [63]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [64]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [65]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [66]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [67]
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Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [68]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [69]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [70]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [71]
Cepharanthine DM9Y5JB N. A. N. A. Approved [72]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [73]
Clozapine DMFC71L Schizophrenia 6A20 Approved [74]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [75]
Trifluoperazine DMKBYWI Anxiety Approved [76]
Olanzapine DMPFN6Y Bipolar depression Approved [74]
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Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [77]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [77]
Gefitinib DM15F0X Colon adenocarcinoma Approved [78]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [79]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [80]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [83]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [84]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [85]
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Drug(s) Affected By E3 SUMO-protein ligase CBX4 (CBX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Leflunomide DMR8ONJ Arthritis FA20 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Menthol DMG2KW7 Back pain ME84.Z Approved [90]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [91]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [93]
Arsenic DMTL2Y1 N. A. N. A. Approved [94]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [95]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [96]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [97]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [99]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [100]
Selenium DM25CGV N. A. N. A. Approved [101]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [96]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [102]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [104]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [108]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [109]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [111]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [112]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [119]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [120]
Testosterone DM7HUNW Hot flushes GA30 Approved [121]
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Drug(s) Affected By Serine/threonine-protein kinase 17B (STK17B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [123]
Testosterone DM7HUNW Hot flushes GA30 Approved [121]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [121]
Leflunomide DMR8ONJ Arthritis FA20 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [124]
Menthol DMG2KW7 Back pain ME84.Z Approved [90]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [125]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [92]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [126]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [128]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [129]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [130]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [131]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [132]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [134]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [135]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [139]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [141]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [142]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [143]
Testosterone DM7HUNW Hot flushes GA30 Approved [144]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [145]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [146]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Gefitinib DM15F0X Colon adenocarcinoma Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Selenium DM25CGV N. A. N. A. Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [153]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [154]
Gefitinib DM15F0X Colon adenocarcinoma Approved [155]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [105]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [158]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Gefitinib DM15F0X Colon adenocarcinoma Approved [160]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [161]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [162]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [163]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [164]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [163]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [165]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [167]
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Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [168]
Selenium DM25CGV N. A. N. A. Approved [150]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [168]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Panobinostat DM58WKG Chronic graft versus host disease Approved [110]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [171]
Testosterone DM7HUNW Hot flushes GA30 Approved [113]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [168]
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Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [173]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [174]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Selenium DM25CGV N. A. N. A. Approved [176]
Etretinate DM2CZFA Keratosis ED56 Approved [177]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [164]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [178]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [179]
Methotrexate DM2TEOL Anterior urethra cancer Approved [180]
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Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [181]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [182]
Selenium DM25CGV N. A. N. A. Approved [150]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [183]
Etretinate DM2CZFA Keratosis ED56 Approved [184]
Methotrexate DM2TEOL Anterior urethra cancer Approved [185]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [186]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [187]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [189]
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Drug(s) Affected By Transcription factor JunD (JUND)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [190]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [179]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [192]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [193]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [194]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [195]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [196]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [197]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [196]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [115]
Gefitinib DM15F0X Colon adenocarcinoma Approved [198]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [199]
Methotrexate DM2TEOL Anterior urethra cancer Approved [200]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [201]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [203]
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Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [136]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [173]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [147]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [204]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [205]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [180]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [206]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [79]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [208]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [209]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [210]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [211]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [212]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [213]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [216]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [217]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [218]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [219]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [220]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [221]
Gefitinib DM15F0X Colon adenocarcinoma Approved [222]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [223]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [225]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [216]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [226]
Paclitaxel DMLB81S Breast carcinoma Approved [227]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [228]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [215]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [79]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [218]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [219]
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Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [229]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [230]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [231]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [232]
Gefitinib DM15F0X Colon adenocarcinoma Approved [233]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [234]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [235]
Selenium DM25CGV N. A. N. A. Approved [150]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [236]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [237]
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Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [238]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [239]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [122]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [240]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [241]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [242]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [243]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [244]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [245]
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Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [246]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [79]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [247]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [248]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [249]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [250]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [251]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [253]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [254]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [174]
Gefitinib DM15F0X Colon adenocarcinoma Approved [255]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [204]
Etretinate DM2CZFA Keratosis ED56 Approved [177]
Prednisone DM2HG4X Acute asthma CA23 Approved [256]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [164]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [96]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [257]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [258]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [259]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [260]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [261]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [262]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [263]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [264]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [265]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [208]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [266]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [267]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [268]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [269]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [162]
Meloxicam DM2AR7L Arthritis FA20 Approved [271]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [272]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [273]
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Drug(s) Affected By Friend leukemia integration 1 transcription factor (FLI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [120]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [274]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [275]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [276]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [277]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [278]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [279]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [122]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein EWS (EWSR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Selenium DM25CGV N. A. N. A. Approved [150]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [280]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [281]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [281]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [282]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [283]
Benzatropine DMF7EXL Parkinsonian disorder Approved [284]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [286]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [287]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [288]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [289]
Testosterone DM7HUNW Hot flushes GA30 Approved [121]
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [238]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [121]
Leflunomide DMR8ONJ Arthritis FA20 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [218]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [247]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [290]
Methotrexate DM2TEOL Anterior urethra cancer Approved [291]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [292]
Quercetin DM3NC4M Obesity 5B81 Approved [293]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [294]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [247]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [295]
Ethacrynic acid DM60QMR Edema MG29 Approved [296]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [297]
Methotrexate DM2TEOL Anterior urethra cancer Approved [298]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [245]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [300]
Leflunomide DMR8ONJ Arthritis FA20 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [301]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [275]
Clozapine DMFC71L Schizophrenia 6A20 Approved [302]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Spectrin alpha chain, non-erythrocytic 1 (SPTAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [150]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [303]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [304]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [283]
Menthol DMG2KW7 Back pain ME84.Z Approved [90]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [306]
Quercetin DM3NC4M Obesity 5B81 Approved [307]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [308]
Artemether DM48QOT Malaria 1F40-1F45 Approved [309]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [310]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [194]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [311]
Estrone DM5T6US Acne vulgaris ED80 Approved [312]
Leflunomide DMR8ONJ Arthritis FA20 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [314]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [315]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Quercetin DM3NC4M Obesity 5B81 Approved [316]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [317]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [318]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [319]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H3.1t (H3-4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [321]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [322]
Panobinostat DM58WKG Chronic graft versus host disease Approved [323]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [324]
Arsenic DMTL2Y1 N. A. N. A. Approved [325]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [326]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [327]
Berberine DMC5Q8X N. A. N. A. Phase 4 [328]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [329]
Quercetin DM3NC4M Obesity 5B81 Approved [330]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [332]
Tazarotene DM8SMD1 Acne vulgaris ED80 Approved [333]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [333]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [333]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [334]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [335]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [333]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [336]
Quercetin DM3NC4M Obesity 5B81 Approved [337]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [107]
Menthol DMG2KW7 Back pain ME84.Z Approved [90]
Arsenic DMTL2Y1 N. A. N. A. Approved [338]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [339]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [340]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [282]
Urethane DM7NSI0 N. A. N. A. Phase 4 [341]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [342]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [343]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [344]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [345]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [346]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [347]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [348]
Ethacrynic acid DM60QMR Edema MG29 Approved [349]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [350]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [351]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [352]
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Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [353]
Folic Acid DMEMBJC Colorectal carcinoma Approved [354]
Methotrexate DM2TEOL Anterior urethra cancer Approved [355]
Quercetin DM3NC4M Obesity 5B81 Approved [356]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [357]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [358]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [359]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [360]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [361]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [361]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [232]
Selenium DM25CGV N. A. N. A. Approved [150]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [362]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [202]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [214]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [363]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [364]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [365]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Histone deacetylase 1 (HDAC1) TT6R7JZ HDAC1_HUMAN Inhibitor [4]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [5]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [6]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [7]
Cytochrome P450 2B6 (CYP2B6) DEPKLMQ CP2B6_HUMAN Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Gene/Protein Processing [9]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [10]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Gene/Protein Processing [11]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [12]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Gene/Protein Processing [13]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [14]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Protein Interaction/Cellular Processes [15]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Gene/Protein Processing [11]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Gene/Protein Processing [14]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Gene/Protein Processing [16]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7006).
2 Romidepsin FDA Label
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
5 Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503.
6 A phase I/II trial of the histone deacetylase inhibitor romidepsin for adults with recurrent malignant glioma: North American Brain Tumor Consortium Study 03-03. Neuro Oncol. 2011 May;13(5):509-16.
7 Population pharmacokinetics of romidepsin in patients with cutaneous T-cell lymphoma and relapsed peripheral T-cell lymphoma. Clin Cancer Res. 2009 Feb 15;15(4):1496-503.
8 FDA Label of Romidepsin. The 2020 official website of the U.S. Food and Drug Administration.
9 Chemoresistance to depsipeptide FK228 [(E)-(1S,4S,10S,21R)-7-[(Z)-ethylidene]-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8,7,6]-tricos-16-ene-3,6,9,22-pentanone] is mediated by reversible MDR1 induction in human cancer cell lines. J Pharmacol Exp Ther. 2005 Jul;314(1):467-75. doi: 10.1124/jpet.105.083956. Epub 2005 Apr 15.
10 Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001.
11 5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer). Biochem Biophys Res Commun. 2006 Dec 15;351(2):455-61. doi: 10.1016/j.bbrc.2006.10.055. Epub 2006 Oct 18.
12 Histone deacetylase inhibitors FK228, N-(2-aminophenyl)-4-[N-(pyridin-3-yl-methoxycarbonyl)amino- methyl]benzamide and m-carboxycinnamic acid bis-hydroxamide augment radiation-induced cell death in gastrointestinal adenocarcinoma cells. Int J Cancer. 2004 Jun 10;110(2):301-8. doi: 10.1002/ijc.20117.
13 Aberrant promoter methylation of the ABCG2 gene in renal carcinoma. Mol Cell Biol. 2006 Nov;26(22):8572-85.
14 Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells. Clin Cancer Res. 2004 Mar 1;10(5):1813-25. doi: 10.1158/1078-0432.ccr-0901-3.
15 Interactions between bortezomib and romidepsin and belinostat in chronic lymphocytic leukemia cells. Clin Cancer Res. 2008 Jan 15;14(2):549-58. doi: 10.1158/1078-0432.CCR-07-1934.
16 Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells. Blood. 2006 Feb 15;107(4):1546-54. doi: 10.1182/blood-2004-10-4126. Epub 2005 Oct 13.
17 Protein methyltransferases as a target class for drug discovery. Nat Rev Drug Discov. 2009 Sep;8(9):724-32.
18 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
19 Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Sep;14(3):471-9.
20 NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma. Blood. 2003 Oct 1;102(7):2615-22.
21 Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127.
22 Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
23 2011 Pipeline of 4SC AG.
24 Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84.
25 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
26 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
27 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
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