Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMTCMH7)

• Drug Name: 1,4-Naphthoquinone Drug Info
• Synonyms: 1,4-NAPHTHOQUINONE; 130-15-4; naphthalene-1,4-dione; p-Naphthoquinone; NAPHTHOQUINONE; alpha-Naphthoquinone; 1,4-Naphthylquinone; USAF CY-10; 1,4-dihydronaphthalene-1,4-dione; 1,4-Dihydro-1,4-diketonaphthalene; 1,4-Naftochinon; RCRA waste number U166; UNII-RBF5ZU7R7K; NSC 9583; 1,4-Naftochinon [Czech]; 1,4-Naphthaquinone; CCRIS 5424; HSDB 2037; EINECS 204-977-6; RBF5ZU7R7K; RCRA waste no U166; CHEMBL55934; AI3-24292; NQ-1; CHEBI:27418; NSC9583; FRASJONUBLZVQX-UHFFFAOYSA-N; MFCD00001676; 1,4-naphtho-quinone

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 8530
  ChEBI ID: CHEBI:27418
  CAS Number: CAS 130-15-4
  TTD Drug ID: DMTCMH7
  INTEDE Drug ID: DR2714

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[11]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[12]
Atovaquone	DMY4UMW	Fungal infection	1F29-1F2F	Approved	[13]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[1]
Acetate Ion	DMD08RH	Discovery agent	N.A.	Investigative	[14]
B-Octylglucoside	DMMO75G	Discovery agent	N.A.	Investigative	[14]
Orotate	DMMB29S	Discovery agent	N.A.	Investigative	[15]
Lauryl Dimethylamine-N-Oxide	DM3W2OE	Discovery agent	N.A.	Investigative	[14]
Dihydroorotate	DM76BGZ	Discovery agent	N.A.	Investigative	[16]

Drug(s) Targeting Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[17]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[2]
BMS-986205	DM3MAYQ	Melanoma	2C30	Phase 3	[18]
INCB24360	DMIJGT9	Urothelial carcinoma	2C92.0	Phase 3	[19]
NLG8189	DM0798Z	Melanoma	2C30	Phase 2/3	[18]
DN1406131	DMQFX8R	Solid tumour/cancer	2A00-2F9Z	Phase 1	[20]
HTI-1090	DMI4TEC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[21]
KHK2455	DMLSUQ8	Solid tumour/cancer	2A00-2F9Z	Phase 1	[18]
LY3381916	DMONZ1L	Solid tumour/cancer	2A00-2F9Z	Phase 1	[18]
PF-06840003	DMOX6EJ	Glioma	2A00.0	Phase 1	[22]

Drug(s) Metabolized By Sulfide-quinone reductase (SQR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BENZOQUINONE	DMNBA0G	Discovery agent	N.A.	Investigative	[3]

Drug(s) Affected By Dihydroorotate dehydrogenase (DHODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Atovaquone	DMY4UMW	Fungal infection	1F29-1F2F	Approved	[1]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[30]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[1]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[31]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[31]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[31]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[33]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[34]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[35]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[36]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[37]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[38]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[41]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[42]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[43]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[44]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[45]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[46]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[47]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[48]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[49]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[50]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[55]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[56]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[57]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[60]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[61]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[63]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[23]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[66]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[67]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[68]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[69]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[70]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[72]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[75]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[76]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[77]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[78]
Fructose	DM43AN2	Vomiting	MD90	Approved	[38]
Ketoprofen	DMRKXPT	Bursitis		Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[79]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[81]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[82]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[89]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[90]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[89]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[91]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[92]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[93]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[94]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[97]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[98]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[102]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[100]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[103]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[104]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[105]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[106]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[107]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[109]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[110]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[84]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[112]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[113]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[114]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[117]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[119]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[124]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[127]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[119]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[128]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[129]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[118]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[80]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[121]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[132]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[139]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[140]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[151]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[152]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[153]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[158]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[164]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[165]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[166]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[103]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[107]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[168]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[169]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[90]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[174]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[179]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[101]
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[184]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 3 (TRPV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Camphor	DMWIO46	Acute or chronic pain	MG30-MG31	Approved	[185]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[188]
Manganese	DMKT129	N. A.	N. A.	Investigative	[189]
1,2-NAPHTHOQUINONE	DMYXELH	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[191]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[42]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[192]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[43]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[34]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[43]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[191]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[38]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[193]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[43]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[42]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[194]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[43]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[195]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[42]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[43]

Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[197]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[196]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[197]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[198]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[196]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[196]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[196]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[199]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[200]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[201]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[202]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[203]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[204]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[205]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[38]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[191]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[192]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[207]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[208]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[209]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[210]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[211]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[212]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[213]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[214]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[215]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[216]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[217]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[219]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[217]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[217]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[39]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[40]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[45]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[45]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[220]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[221]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[224]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[221]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[227]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[228]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[229]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[230]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[218]

Drug(s) Affected By Cytochrome P450 2C18 (CYP2C18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[197]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[232]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By L-xylulose reductase (DCXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[238]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[239]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[240]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[241]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[49]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[243]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[244]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[245]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[246]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[247]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[248]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[249]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[97]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[250]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[251]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[252]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[254]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[255]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[32]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[43]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[256]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[257]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Indoleamine 2,3-dioxygenase 1 (IDO1)	TTZJYKH	I23O1_HUMAN	Inhibitor	[2]
Plasmodium Dihydroorotate dehydrogenase (Malaria DHOdehase)	TT3PQ2Y	PYRD_PLAF7	Inhibitor	[1]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Sulfide-quinone reductase (SQR) Main DME	DEGLTNR	SQRD_ACIF2	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Protein Interaction/Cellular Processes	[5]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[6]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[4]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Gene/Protein Processing	[7]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Gene/Protein Processing	[5]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Gene/Protein Processing	[8]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Regulation of Drug Effects	[9]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Regulation of Drug Effects	[9]

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