Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMLB81S)

Drug Name
Paclitaxel Drug Info
Synonyms
5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-b; 7-epi-Paclitaxel; ABI-007; Abraxane; Capxol; Ebetaxel; EmPAC; Genaxol; Genetaxyl; Genexol; Intaxel; LipoPac; OncoGel; Onxol; Paclitaxel (Taxol); Paxceed; Paxene; Plaxicel; TAXOL; TaxAlbin; Taxol A; Xorane; Yewtaxan; Zisu; nab-paclitaxel; paclitaxel
Indication
Disease Entry ICD 11 Status REF
Breast carcinoma Approved [1]
Cutaneous melanoma 2C30 Approved [1]
Cutaneous squamous cell carcinoma 2C30 Approved [1]
Epithelial ovarian cancer 2B5D Approved [1]
Extragonadal germ cell tumor Approved [1]
Fallopian tube neoplasm Approved [1]
Gastroesophageal junction adenocarcinoma 2B71 Approved [1]
Inflammatory breast cancer 2C62 Approved [1]
Kaposi sarcoma 2B57 Approved [1]
Lung adenocarcinoma Approved [1]
Lung cancer 2C25.0 Approved [1]
Non-small-cell lung cancer 2C25.Y Approved [1]
Ocular hypertension 9C61.01 Approved [1]
Ovarian neoplasm Approved [1]
Ovarian serous cystadenocarcinoma Approved [1]
Pain MG30-MG3Z Approved [1]
Pancreatic ductal carcinoma 2C10.0 Approved [1]
Primary peritoneal carcinoma Approved [1]
Testicular germ cell tumor Approved [1]
Urethral cancer 2C93 Approved [1]
Lung large cell carcinoma Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
36314
ChEBI ID
ChEBI:45863
CAS Number
CAS 33069-62-4
TTD Drug ID
DMLB81S
VARIDT Drug ID
DR00342

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Investigative Drug(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [23]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [25]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [26]
Verapamil DMA7PEW Angina pectoris BA40 Approved [8]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [27]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [28]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [29]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [30]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [125]
Folic Acid DMEMBJC Colorectal carcinoma Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Quercetin DM3NC4M Obesity 5B81 Approved [126]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [127]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [122]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [129]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [130]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [130]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [31]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
Folic Acid DMEMBJC Colorectal carcinoma Approved [33]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [34]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [35]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [36]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [37]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [38]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [39]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [40]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [8]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [41]
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Folic Acid DMEMBJC Colorectal carcinoma Approved [43]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [42]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [42]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [44]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [45]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Folic Acid DMEMBJC Colorectal carcinoma Approved [49]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [50]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [51]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [54]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [55]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporter 2 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [56]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [5]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [57]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [58]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [59]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [60]
Aciclovir DMYLOVR Genital herpes 1A94 Approved [61]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [62]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [63]
Theophylline DMRJFN9 Bronchitis CA20 Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [64]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [65]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [66]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [67]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [66]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [68]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [69]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [70]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [71]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [72]
Folic Acid DMEMBJC Colorectal carcinoma Approved [23]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [73]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [74]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [75]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [76]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [77]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [78]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [79]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [80]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance protein 3 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [2]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [2]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [2]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [81]
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [66]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [84]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [66]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [85]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [69]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [71]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [86]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [71]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By TAP-like protein (ABCB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [87]
Drug(s) Transported By Multidrug resistance-associated protein 7 (ABCC10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [4]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [4]
Tenofovir DM1IS6U Chronic hepatitis B virus infection Approved [88]
Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [89]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [89]
Gefitinib DM15F0X Colon adenocarcinoma Approved [90]
Sunitinib DMCBJSR Acute undifferentiated leukemia Approved [91]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [92]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [96]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 10 (ABCC10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [96]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [103]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [105]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [106]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [107]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [108]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Prednisone DM2HG4X Acute asthma CA23 Approved [112]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [113]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [114]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [116]
Sulfinpyrazone DMEV954 Gout FA25 Approved [117]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [118]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [119]
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [121]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [115]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [122]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [123]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [131]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [132]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [133]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [134]
Cepharanthine DM9Y5JB N. A. N. A. Approved [135]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [136]
Clozapine DMFC71L Schizophrenia 6A20 Approved [137]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [138]
Trifluoperazine DMKBYWI Anxiety Approved [139]
Olanzapine DMPFN6Y Bipolar depression Approved [137]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [140]
Methysergide DM1EF73 Migraine 8A80 Approved [141]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [141]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [149]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [96]
Allopurinol DMLPAOB Gout FA25 Approved [5]
Bumetanide DMRV7H0 Congestive heart failure BD10 Approved [5]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [5]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [5]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [5]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [62]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [149]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 20 (CDK20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [151]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [152]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [153]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [154]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [158]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [159]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [160]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [161]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipoprotein lipase (LPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [168]
Benzbromarone DMC3YUA Gout FA25 Approved [170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [171]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [172]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [173]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [174]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [175]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [177]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [178]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [180]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [182]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [183]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [184]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [187]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [188]
Flucytosine DM13VTW Cryptococcal meningitis Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [193]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Folic Acid DMEMBJC Colorectal carcinoma Approved [196]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aprepitant DM053KT Depression 6A70-6A7Z Approved [199]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [204]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [205]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [206]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aprepitant DM053KT Depression 6A70-6A7Z Approved [199]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [210]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [211]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [212]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [206]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [213]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [214]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aprepitant DM053KT Depression 6A70-6A7Z Approved [199]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [215]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [216]
Quercetin DM3NC4M Obesity 5B81 Approved [217]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [218]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [220]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Uracil mustard DMHL7OB Acute myeloid leukaemia 2A60 Approved [91]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Gefitinib DM15F0X Colon adenocarcinoma Approved [567]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [568]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [569]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [570]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [569]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [571]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [572]
Methotrexate DM2TEOL Anterior urethra cancer Approved [573]
⏷ Show the Full List of 12 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [222]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [222]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [223]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [224]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [225]
Etidronic acid DM1XHYJ Bone Paget disease Approved [222]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [222]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [222]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [226]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aromatase (CYP19A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [228]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [229]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [230]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [230]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
FADROZOLE DM3C5GZ Breast cancer 2C60-2C65 Approved [231]
Bifonazole DM3KN7V Fungal infection 1F29-1F2F Approved [232]
Quercetin DM3NC4M Obesity 5B81 Approved [233]
Fluoxetine DM3PD2C Bipolar depression Approved [230]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [234]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [236]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [237]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [238]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [238]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [239]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [240]
Capsaicin DMGMF6V Back pain ME84.Z Approved [241]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [243]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [244]
Tegafur DM31ZQM Solid tumour/cancer 2A00-2F9Z Approved [245]
Flucytosine DM13VTW Cryptococcal meningitis Approved [91]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [248]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [249]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [250]
Methotrexate DM2TEOL Anterior urethra cancer Approved [248]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [248]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [253]
Selenium DM25CGV N. A. N. A. Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Quercetin DM3NC4M Obesity 5B81 Approved [255]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [256]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [205]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [257]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [258]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Olaparib DM8QB1D Ovarian cancer 2C73 Approved [260]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [261]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [262]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [91]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [263]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [264]
Quercetin DM3NC4M Obesity 5B81 Approved [265]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [266]
Fructose DM43AN2 Vomiting MD90 Approved [267]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [269]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [271]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [272]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [273]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [274]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [275]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [277]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [277]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [277]
Capsaicin DMGMF6V Back pain ME84.Z Approved [278]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [279]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [280]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [281]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [282]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [283]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [284]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [285]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [286]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [288]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [289]
Capsaicin DMGMF6V Back pain ME84.Z Approved [278]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [238]
Quinidine DMLPICK N. A. N. A. Approved [290]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [291]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [235]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [292]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [238]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [237]
Capsaicin DMGMF6V Back pain ME84.Z Approved [278]
Zafirlukast DMHNQOG Asthma CA23 Approved [293]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [238]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [294]
Fluconazole DMOWZ6B Cryptococcal meningitis Approved [237]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [295]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [296]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [296]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [297]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [295]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [296]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [141]
Gefitinib DM15F0X Colon adenocarcinoma Approved [295]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [298]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [295]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [300]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [301]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [302]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [303]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [304]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Capsaicin DMGMF6V Back pain ME84.Z Approved [307]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfhydryl oxidase 1 (QSOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [310]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 5 (TRAF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [318]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [319]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [320]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [321]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc box-dependent-interacting protein 1 (BIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [324]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Bortezomib DMNO38U Leukemia Approved [325]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleoside diphosphate kinase, mitochondrial (NME4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Folic Acid DMEMBJC Colorectal carcinoma Approved [196]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Potassium channel subfamily K member 3 (KCNK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [331]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [332]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [333]
Riociguat DMXBLMP Chronic thromboembolic pulmonary hypertension Approved [334]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [335]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [336]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [220]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [305]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [337]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acyl-coenzyme A thioesterase 8 (ACOT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Orlistat DMRJSP8 Obesity 5B81 Approved [20]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
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Drug(s) Affected By Telomerase reverse transcriptase (TERT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [340]
Gefitinib DM15F0X Colon adenocarcinoma Approved [341]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [342]
Selenium DM25CGV N. A. N. A. Approved [343]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [344]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [345]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [346]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [347]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [348]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [349]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [350]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [351]
Selenium DM25CGV N. A. N. A. Approved [352]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [348]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [353]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [353]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuropilin-1 (NRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [354]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aurora kinase A (AURKA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [362]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [254]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Gefitinib DM15F0X Colon adenocarcinoma Approved [368]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [369]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Etretinate DM2CZFA Keratosis ED56 Approved [370]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [371]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [372]
Quercetin DM3NC4M Obesity 5B81 Approved [373]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [375]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [375]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [377]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [375]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Bortezomib DMNO38U Leukemia Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [120]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [379]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [73]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [381]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [382]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [383]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [384]
Selenium DM25CGV N. A. N. A. Approved [385]
Quercetin DM3NC4M Obesity 5B81 Approved [384]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Ethanol DMDRQZU Chronic pain MG30 Approved [386]
Folic Acid DMEMBJC Colorectal carcinoma Approved [387]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [388]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [389]
Arsenic DMTL2Y1 N. A. N. A. Approved [385]
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Drug(s) Affected By Retinoschisin (RS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [390]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [391]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [392]
Drug(s) Affected By Kunitz-type protease inhibitor 2 (SPINT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylate cyclase type 6 (ADCY6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [396]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [397]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [17]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [398]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic checkpoint protein BUB3 (BUB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [399]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [400]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [401]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid phosphatase 2 (PLPP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [402]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [403]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [404]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin protein zero-like protein 2 (MPZL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [409]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase CDC14B (CDC14B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [410]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [411]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [412]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [254]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [413]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [415]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [416]
Quercetin DM3NC4M Obesity 5B81 Approved [417]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [416]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [418]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [419]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [416]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death effector domain-containing protein (DEDD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [420]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [421]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [321]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine hydrolase RBBP9 (RBBP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [423]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [424]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 13 (TNFSF13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [342]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [425]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [426]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [427]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [428]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [427]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [429]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [430]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [431]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [433]
Quercetin DM3NC4M Obesity 5B81 Approved [354]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [434]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [435]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Securin (PTTG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [437]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [439]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [348]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [440]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [441]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [442]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [443]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [444]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [446]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [448]
Gefitinib DM15F0X Colon adenocarcinoma Approved [449]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [450]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [451]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [452]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [453]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Selenium DM25CGV N. A. N. A. Approved [454]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [455]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [456]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Gefitinib DM15F0X Colon adenocarcinoma Approved [457]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [342]
Selenium DM25CGV N. A. N. A. Approved [458]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [459]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [460]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [461]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pro-epidermal growth factor (EGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [462]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [463]
Quercetin DM3NC4M Obesity 5B81 Approved [464]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [465]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [466]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [467]
Gefitinib DM15F0X Colon adenocarcinoma Approved [468]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [469]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [470]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [469]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [471]
Selenium DM25CGV N. A. N. A. Approved [472]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [473]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [474]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [155]
Diazepam DM08E9O Alcohol withdrawal Approved [475]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [477]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [478]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [479]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [480]
Quercetin DM3NC4M Obesity 5B81 Approved [481]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [482]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor (ESR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [483]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [484]
Gefitinib DM15F0X Colon adenocarcinoma Approved [485]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [158]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [451]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [486]
Quercetin DM3NC4M Obesity 5B81 Approved [487]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [488]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [158]
Estrone DM5T6US Acne vulgaris ED80 Approved [489]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [491]
Quercetin DM3NC4M Obesity 5B81 Approved [492]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [493]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [220]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [494]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [495]
Testosterone DM7HUNW Hot flushes GA30 Approved [496]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [497]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [498]
Selenium DM25CGV N. A. N. A. Approved [472]
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [500]
Epinephrine DM3KJBC Acute asthma CA23 Approved [501]
Quercetin DM3NC4M Obesity 5B81 Approved [502]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [503]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [504]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
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Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ethanol DMDRQZU Chronic pain MG30 Approved [318]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Bortezomib DMNO38U Leukemia Approved [308]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [198]
Arsenic DMTL2Y1 N. A. N. A. Approved [506]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [507]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [508]
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Drug(s) Affected By Apolipoprotein D (APOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [510]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [511]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [360]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [513]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
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Drug(s) Affected By Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
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Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [516]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [517]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [518]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [441]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [418]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [519]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [520]
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Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [499]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [521]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [523]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [524]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [467]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [471]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [525]
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
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Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [526]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [526]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [527]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [528]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [529]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [530]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [531]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [532]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [533]
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Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [534]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [535]
Fructose DM43AN2 Vomiting MD90 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [536]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [537]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [538]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [539]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [540]
Methotrexate DM2TEOL Anterior urethra cancer Approved [541]
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Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [542]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [543]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [544]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [545]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [542]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [398]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Selenium DM25CGV N. A. N. A. Approved [246]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [546]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [547]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [466]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
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Drug(s) Affected By Gelsolin (GSN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [549]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [550]
Gefitinib DM15F0X Colon adenocarcinoma Approved [551]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [552]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [460]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [553]
Methotrexate DM2TEOL Anterior urethra cancer Approved [554]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [555]
Quercetin DM3NC4M Obesity 5B81 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [556]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [458]
Etretinate DM2CZFA Keratosis ED56 Approved [370]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [557]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [558]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [559]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [558]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [558]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Fluoxetine DM3PD2C Bipolar depression Approved [558]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [560]
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Drug(s) Affected By Prosaposin (PSAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [561]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [561]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Bortezomib DMNO38U Leukemia Approved [308]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [561]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [561]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [476]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SPARC (SPARC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [563]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [439]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [439]
Ethanol DMDRQZU Chronic pain MG30 Approved [564]
Folic Acid DMEMBJC Colorectal carcinoma Approved [565]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [566]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [574]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [575]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [576]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [523]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [537]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [467]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [469]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [470]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [577]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [469]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [578]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [578]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [578]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [579]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [580]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [581]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [582]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [583]
Selenium DM25CGV N. A. N. A. Approved [584]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [585]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated protein tau (MAPT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [586]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [587]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [498]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [588]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [589]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [590]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [591]
Selenium DM25CGV N. A. N. A. Approved [458]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [592]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [593]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [594]
Quercetin DM3NC4M Obesity 5B81 Approved [440]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Selenium DM25CGV N. A. N. A. Approved [458]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [595]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [596]
Meloxicam DM2AR7L Arthritis FA20 Approved [597]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Epinephrine DM3KJBC Acute asthma CA23 Approved [598]
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Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [509]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [599]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [509]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [600]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(VI) chain (COL6A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Selenium DM25CGV N. A. N. A. Approved [246]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [599]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [602]
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Drug(s) Affected By ADP/ATP translocase 1 (SLC25A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [336]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Folic Acid DMEMBJC Colorectal carcinoma Approved [603]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bone morphogenetic protein 4 (BMP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [604]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [605]
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Drug(s) Affected By Elongation factor 2 (EEF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [606]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [607]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Arsenic DMTL2Y1 N. A. N. A. Approved [608]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [609]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [610]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [609]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
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Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [91]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [91]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [611]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [612]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [613]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Haloperidol DM96SE0 Delirium Approved [614]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [324]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [615]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [615]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [616]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [455]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [618]
Estrone DM5T6US Acne vulgaris ED80 Approved [543]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [619]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [620]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [621]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [622]
Selenium DM25CGV N. A. N. A. Approved [246]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [623]
Etretinate DM2CZFA Keratosis ED56 Approved [624]
Methotrexate DM2TEOL Anterior urethra cancer Approved [625]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [626]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [627]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [628]
Quercetin DM3NC4M Obesity 5B81 Approved [629]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [630]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [631]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [632]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-6 (ITGB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Bortezomib DMNO38U Leukemia Approved [308]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [566]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [633]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [634]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [350]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Selenium DM25CGV N. A. N. A. Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [418]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [419]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [272]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [635]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [636]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA ligase 1 (LIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [605]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/hydrogen exchanger 1 (SLC9A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [637]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [638]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [96]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-L (ITGAL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [639]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [640]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [641]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Bortezomib DMNO38U Leukemia Approved [308]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin-A1 (EFNA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Estrone DM5T6US Acne vulgaris ED80 Approved [543]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [643]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Methotrexate DM2TEOL Anterior urethra cancer Approved [644]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [643]
Ethacrynic acid DM60QMR Edema MG29 Approved [645]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [206]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [643]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [530]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [646]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [647]
Methotrexate DM2TEOL Anterior urethra cancer Approved [648]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [649]
Quercetin DM3NC4M Obesity 5B81 Approved [650]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [651]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [652]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [653]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [654]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins A2/B1 (HNRNPA2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Quercetin DM3NC4M Obesity 5B81 Approved [655]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [656]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [658]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [607]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [324]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [660]
Selenium DM25CGV N. A. N. A. Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [662]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [663]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [348]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [664]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Follicle-stimulating hormone receptor (FSHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [175]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [175]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [665]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [666]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [667]
MICROCYSTIN-LR DMTMLRN Discovery agent N.A. Investigative [668]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [669]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [670]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [671]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [484]
Gefitinib DM15F0X Colon adenocarcinoma Approved [449]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [552]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [672]
Selenium DM25CGV N. A. N. A. Approved [246]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [459]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [673]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [556]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [674]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [675]
Selenium DM25CGV N. A. N. A. Approved [458]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [570]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [676]
Methotrexate DM2TEOL Anterior urethra cancer Approved [644]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [593]
Quercetin DM3NC4M Obesity 5B81 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer CD24 (CD24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [677]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [678]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [679]
Epinephrine DM3KJBC Acute asthma CA23 Approved [680]
Quercetin DM3NC4M Obesity 5B81 Approved [637]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [681]
Fructose DM43AN2 Vomiting MD90 Approved [682]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [476]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-P (S100P)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [683]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Estrone DM5T6US Acne vulgaris ED80 Approved [684]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [685]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A4 (S100A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [686]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [220]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [685]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [175]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [172]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [687]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [177]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [178]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [179]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [688]
Gefitinib DM15F0X Colon adenocarcinoma Approved [689]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [690]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Arsenic DMTL2Y1 N. A. N. A. Approved [691]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [400]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [693]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Gefitinib DM15F0X Colon adenocarcinoma Approved [468]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [694]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [471]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [532]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [695]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [696]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [698]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [699]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adenylosuccinate synthetase isozyme 2 (ADSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [606]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [700]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [701]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [702]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [595]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Quercetin DM3NC4M Obesity 5B81 Approved [354]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [254]
Testosterone DM7HUNW Hot flushes GA30 Approved [703]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [704]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [705]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [707]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [708]
Haloperidol DM96SE0 Delirium Approved [614]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [709]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Benzatropine DMF7EXL Parkinsonian disorder Approved [614]
Clozapine DMFC71L Schizophrenia 6A20 Approved [614]
Mecamylamine DMGQFYB Essential hypertension BA00 Approved [709]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syndecan-2 (SDC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [426]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [536]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [711]
Quercetin DM3NC4M Obesity 5B81 Approved [637]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [712]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [713]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [714]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [715]
Testosterone DM7HUNW Hot flushes GA30 Approved [716]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [717]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 7 (PTPN7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [718]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [103]
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [719]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [720]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [721]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [722]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [723]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [724]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [725]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [469]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [726]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibrillin-1 (FBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [727]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [728]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [729]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [730]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [350]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [416]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [731]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [732]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pigment epithelium-derived factor (SERPINF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [733]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [733]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [484]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [734]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [557]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [735]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [736]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [442]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [737]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [538]
Gefitinib DM15F0X Colon adenocarcinoma Approved [368]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [552]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Etretinate DM2CZFA Keratosis ED56 Approved [370]
Prednisone DM2HG4X Acute asthma CA23 Approved [738]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [570]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Capsaicin DMGMF6V Back pain ME84.Z Approved [739]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [724]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [740]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [741]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [742]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [743]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [744]
Quercetin DM3NC4M Obesity 5B81 Approved [745]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Replication factor C subunit 5 (RFC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [746]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Clozapine DMFC71L Schizophrenia 6A20 Approved [614]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [747]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [748]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [269]
Gefitinib DM15F0X Colon adenocarcinoma Approved [749]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [459]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [750]
Quercetin DM3NC4M Obesity 5B81 Approved [751]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [752]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [753]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [754]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [184]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [755]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [756]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [757]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [758]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [759]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [760]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [536]
Gefitinib DM15F0X Colon adenocarcinoma Approved [761]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [498]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [540]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [519]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [763]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [540]
Ethacrynic acid DM60QMR Edema MG29 Approved [764]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [536]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [540]
Methotrexate DM2TEOL Anterior urethra cancer Approved [765]
Quercetin DM3NC4M Obesity 5B81 Approved [766]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [540]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [767]
Sorbitol DMAN0DE Constipation DD91.1 Approved [768]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Gefitinib DM15F0X Colon adenocarcinoma Approved [769]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [770]
Epinephrine DM3KJBC Acute asthma CA23 Approved [680]
Quercetin DM3NC4M Obesity 5B81 Approved [771]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [772]
Fructose DM43AN2 Vomiting MD90 Approved [682]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [773]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [774]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [775]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Isocitrate dehydrogenase , mitochondrial (IDH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [253]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Folic Acid DMEMBJC Colorectal carcinoma Approved [776]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [614]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [777]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [778]
Selenium DM25CGV N. A. N. A. Approved [246]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [595]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [416]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [779]
Quercetin DM3NC4M Obesity 5B81 Approved [780]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [781]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centromere protein F (CENPF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [782]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-4 (CASP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [538]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [354]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [783]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [784]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [305]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Arsenic DMTL2Y1 N. A. N. A. Approved [785]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [786]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [586]
Gefitinib DM15F0X Colon adenocarcinoma Approved [551]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [788]
Selenium DM25CGV N. A. N. A. Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [789]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [589]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [790]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [419]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [791]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [792]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [793]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [350]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Selenium DM25CGV N. A. N. A. Approved [246]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [794]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [795]
Methotrexate DM2TEOL Anterior urethra cancer Approved [644]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [772]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [708]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 7 (CDK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [354]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [619]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [796]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [420]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [797]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Palmitoyl-protein thioesterase 1 (PPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Orlistat DMRJSP8 Obesity 5B81 Approved [20]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [798]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [799]
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Drug(s) Affected By Dual specificity protein phosphatase 3 (DUSP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Arsenic DMTL2Y1 N. A. N. A. Approved [785]
Gefitinib DM15F0X Colon adenocarcinoma Approved [800]
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Drug(s) Affected By Matrix metalloproteinase-16 (MMP16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [454]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [336]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [802]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-5 (CASP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [695]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [695]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [319]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
9-hydroxyoctadecadienoic acid DM0FWNJ Discovery agent N.A. Investigative [803]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [319]
CHLORANIL DMCHGF1 Discovery agent N.A. Investigative [804]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-H (CCNH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [805]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [783]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [796]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [366]
Arecoline DMFJZK3 Parkinson disease 8A00.0 Phase 1 [806]
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Drug(s) Affected By Activated RNA polymerase II transcriptional coactivator p15 (SUB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [807]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [605]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
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Drug(s) Affected By Epithelial membrane protein 3 (EMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [808]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [441]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [808]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [809]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [810]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [811]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [812]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [812]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [813]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [814]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [628]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [815]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [816]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [817]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [818]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [819]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Meloxicam DM2AR7L Arthritis FA20 Approved [820]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [821]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [822]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-11 (CDH11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [823]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [824]
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Drug(s) Affected By Tumor protein D52 (TPD52)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [643]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [643]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [643]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [693]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [352]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [825]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [826]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [827]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [828]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [829]
Quercetin DM3NC4M Obesity 5B81 Approved [735]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [830]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [831]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [832]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [833]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [834]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [835]
Quercetin DM3NC4M Obesity 5B81 Approved [836]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [837]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [838]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [839]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [658]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [648]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [491]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [465]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [840]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [491]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [841]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [842]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [843]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SH3 domain-binding protein 2 (SH3BP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By General transcription factor II-I (GTF2I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [254]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [845]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [846]
Gefitinib DM15F0X Colon adenocarcinoma Approved [567]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [818]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [847]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [811]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [848]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [849]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [591]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [188]
Gefitinib DM15F0X Colon adenocarcinoma Approved [551]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [553]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [850]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Antigen peptide transporter 1 (TAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [246]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [808]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [808]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [671]
Selenium DM25CGV N. A. N. A. Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [557]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [851]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [852]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [853]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [854]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [855]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [856]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [857]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [858]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [858]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [858]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [859]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C delta type (PRKCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [860]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [861]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [862]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [863]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [864]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [865]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [199]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Verapamil DMA7PEW Angina pectoris BA40 Approved [866]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [818]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [552]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Meloxicam DM2AR7L Arthritis FA20 Approved [597]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [570]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [867]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [868]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [189]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [772]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [177]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [869]
Methotrexate DM2TEOL Anterior urethra cancer Approved [644]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [870]
Quercetin DM3NC4M Obesity 5B81 Approved [637]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [518]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [476]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [871]
Ethacrynic acid DM60QMR Edema MG29 Approved [872]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock protein beta-3 (HSPB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [873]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [874]
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Drug(s) Affected By Lymphocyte cytosolic protein 2 (LCP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [313]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [718]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By FAS-associated death domain protein (FADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Selenium DM25CGV N. A. N. A. Approved [875]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [813]
Quercetin DM3NC4M Obesity 5B81 Approved [819]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [876]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [762]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Arsenic DMTL2Y1 N. A. N. A. Approved [877]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [786]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAGUK p55 subfamily member 3 (MPP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [879]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [880]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [465]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [881]
Pamidronate DMB4AVP Bone Paget disease Approved [882]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [883]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Short transient receptor potential channel 3 (TRPC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Methacholine Chloride DMGS4QH Asthma CA23 Approved [884]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Testosterone DM7HUNW Hot flushes GA30 Approved [885]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [886]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [151]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [499]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein-tyrosine kinase 6 (PTK6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [887]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [406]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID25656651-Compound-5 DMAI95U Chronic myeloid leukaemia 2A20 Patented [888]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
eucalyptol DME5CK3 Discovery agent N.A. Investigative [889]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [890]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [696]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [891]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [892]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [893]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [892]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG3 (BTG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [348]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [619]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [348]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [348]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [348]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [894]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Src substrate cortactin (CTTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [895]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [398]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [398]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caprin-1 (CAPRIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [896]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [897]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [898]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [899]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [900]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Gefitinib DM15F0X Colon adenocarcinoma Approved [769]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [901]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Selenium DM25CGV N. A. N. A. Approved [246]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [821]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Periostin (POSTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [503]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [902]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [903]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Procollagen C-endopeptidase enhancer 1 (PCOLCE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [904]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [355]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor E2F5 (E2F5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated protein RP/EB family member 1 (MAPRE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Benzatropine DMF7EXL Parkinsonian disorder Approved [614]
Clozapine DMFC71L Schizophrenia 6A20 Approved [614]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [605]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [905]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [906]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [907]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [908]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [783]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [909]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [910]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional regulator QRICH1 (QRICH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [911]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [432]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Parafibromin (CDC73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [342]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [913]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inactive caspase-12 (CASP12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [914]
Ethanol DMDRQZU Chronic pain MG30 Approved [915]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [916]
Methamphetamine DMPM4SK Anxiety Approved [917]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [918]
Thymoquinone DMVDTR2 Polycystic ovarian syndrome 5A80.1 Phase 2/3 [919]
Tetrandrine DMAOJBX Sarcoma 2A60-2C35 Phase 1 [920]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [915]
3,7,3',4'-TETRAHYDROXYFLAVONE DMES906 Discovery agent N.A. Investigative [921]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme A synthase COX15 (COX15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [922]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [923]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [923]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [398]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division cycle and apoptosis regulator protein 1 (CCAR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [614]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [410]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Benzatropine DMF7EXL Parkinsonian disorder Approved [614]
Clozapine DMFC71L Schizophrenia 6A20 Approved [614]
Bortezomib DMNO38U Leukemia Approved [924]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [925]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [924]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-2 (SIRT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [926]
Clozapine DMFC71L Schizophrenia 6A20 Approved [927]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [928]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [929]
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [930]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [931]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [932]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [933]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid-transporting ATPase ABCA7 (ABCA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [96]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centromere protein S (CENPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [934]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacylase sirtuin-6 (SIRT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [935]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [936]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [937]
SEN-196 DMLDBQ5 Huntington disease 8A01.10 Phase 2 [938]
TAK-715 DMZKPI8 Rheumatoid arthritis FA20 Phase 2 [939]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
NORCANTHARIDIN DM9B6Y1 Discovery agent N.A. Investigative [940]
paraquat DMR8O3X Discovery agent N.A. Investigative [941]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cholesterol transporter ABCA5 (ABCA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [942]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [943]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [693]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAP kinase-activating death domain protein (MADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [786]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [945]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [421]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [946]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucin-16 (MUC16)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [947]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [948]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [949]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [950]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [951]
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Drug(s) Affected By Rap guanine nucleotide exchange factor 5 (RAPGEF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [952]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [953]
Quercetin DM3NC4M Obesity 5B81 Approved [954]
Estrone DM5T6US Acne vulgaris ED80 Approved [955]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [956]
Testosterone DM7HUNW Hot flushes GA30 Approved [957]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [958]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [959]
Mestranol DMG3F94 Contraception QA21 Approved [960]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [961]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [543]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Estrone DM5T6US Acne vulgaris ED80 Approved [543]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [342]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Mestranol DMG3F94 Contraception QA21 Approved [543]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [543]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-10 (CASP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [962]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [772]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [963]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Engulfment and cell motility protein 3 (ELMO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Drug(s) Affected By p53 apoptosis effector related to PMP-22 (PERP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [964]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [965]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [897]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [625]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [966]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [518]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [967]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [695]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [968]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division cycle 5-like protein (CDC5L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [697]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [969]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [798]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [950]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase phosphoprotein 6 (MPHOSPH6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [970]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [971]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A/B (HNRNPAB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [705]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [607]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [972]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [973]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 243 (TMEM243)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [974]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division cycle-associated protein 7 (CDCA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane gamma-carboxyglutamic acid protein 4 (PRRG4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [807]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [700]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [355]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TRIO and F-actin-binding protein (TRIOBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [975]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [18]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [975]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [950]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family B member 6 (ABCB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [98]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [398]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bridging integrator 3 (BIN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [392]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [200]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [707]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [201]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [976]
Quercetin DM3NC4M Obesity 5B81 Approved [637]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [977]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [826]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-7 (SIRT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [978]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [929]
NORCANTHARIDIN DM9B6Y1 Discovery agent N.A. Investigative [940]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Olfactomedin-like protein 3 (OLFML3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [807]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [979]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2 and S phase-expressed protein 1 (GTSE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [980]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [981]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ETS homologous factor (EHF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [982]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [693]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [633]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [983]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [984]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [985]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [254]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [986]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [987]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase kappa (POLK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [942]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Guanine DMIWLJE N. A. N. A. Phase 3 [988]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
MK-886 DMT0O7H Asthma CA23 Discontinued in Phase 2 [989]
680C91 DMCDTIG Solid tumour/cancer 2A00-2F9Z Preclinical [990]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Hook homolog 1 (HOOK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [873]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PR domain zinc finger protein 4 (PRDM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [991]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box only protein 5 (FBXO5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [443]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurabin-1 (PPP1R9A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Matrix metalloproteinase-17 (MMP17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [844]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [983]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [844]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Microtubule-associated protein RP/EB family member 3 (MAPRE3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [992]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [151]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Selenium DM25CGV N. A. N. A. Approved [246]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RuvB-like 2 (RUVBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [993]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Benzatropine DMF7EXL Parkinsonian disorder Approved [614]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [399]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-type lectin domain family 11 member A (CLEC11A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [994]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [319]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [411]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [995]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [428]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [996]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [997]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-5 (ATF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [998]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [999]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein-arginine deiminase type-2 (PADI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [660]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [991]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [983]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1000]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [337]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [1001]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [971]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
Drug(s) Affected By Small ribosomal subunit protein mS40 (MRPS18B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [971]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [432]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Transforming acidic coiled-coil-containing protein 3 (TACC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [439]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [439]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sorting nexin-10 (SNX10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1002]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [409]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [413]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [416]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [416]
Quercetin DM3NC4M Obesity 5B81 Approved [1003]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [416]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [418]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [419]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [635]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [707]
Verapamil DMA7PEW Angina pectoris BA40 Approved [1004]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [470]
Selenium DM25CGV N. A. N. A. Approved [246]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [1005]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1006]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [500]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [1007]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid phosphatase 1 (PLPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [151]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1002]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [13]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-17 receptor B (IL17RB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [337]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterol-binding protein-related protein 10 (OSBPL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [412]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 13 (NDUFA13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [945]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1008]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [971]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [556]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [538]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [458]
Etretinate DM2CZFA Keratosis ED56 Approved [370]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [570]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1009]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Condensin complex subunit 3 (NCAPG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [746]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-5 (ITGB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [932]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [932]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [932]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [932]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 7 (NDUFB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1010]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [997]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1011]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [1012]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1013]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde oxidase (AOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [503]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [499]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [272]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By U11/U12 small nuclear ribonucleoprotein 25 kDa protein (SNRNP25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1014]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor-like protein 6 (EGFL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [728]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
Indomethacin DMSC4A7 Bursitis Approved [1015]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [355]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [610]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1016]
Topotecan DMP6G8T Central nervous system neoplasm Approved [1016]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Biglycan (BGN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [475]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [252]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytidine deaminase (CDA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1017]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [1018]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [630]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(VII) chain (COL7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [475]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [1019]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Estrone DM5T6US Acne vulgaris ED80 Approved [684]
Ethacrynic acid DM60QMR Edema MG29 Approved [1020]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Furosemide DMMQ8ZG Congestive heart failure BD10 Approved [1020]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [684]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 2, mitochondrial (NDUFB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Selenium DM25CGV N. A. N. A. Approved [246]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1021]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [786]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High mobility group protein B1 (HMGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Gefitinib DM15F0X Colon adenocarcinoma Approved [468]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [1022]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [336]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [893]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Deoxycytidylate deaminase (DCTD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [432]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [1023]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Sorcin (SRI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1024]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1025]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [1026]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [270]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [1027]
Fluoxetine DM3PD2C Bipolar depression Approved [1028]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1029]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1030]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1031]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [1032]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1033]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [499]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [808]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [606]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [1034]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MARVEL domain-containing protein 1 (MARVELD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1035]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1036]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [1036]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [411]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein uS15m (MRPS15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1011]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1037]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [195]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [1038]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Topotecan DMP6G8T Central nervous system neoplasm Approved [18]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1039]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal recognition particle receptor subunit alpha (SRPRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Haloperidol DM96SE0 Delirium Approved [614]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [787]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [693]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1040]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [880]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [503]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1021]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [658]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [503]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-sarcoglycan (SGCB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1041]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [403]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [144]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [424]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1014]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [337]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [1042]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 135 (TMEM135)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [411]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1043]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1044]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Clozapine DMFC71L Schizophrenia 6A20 Approved [1045]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ferritin heavy chain (FTH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [1046]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1047]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1048]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [221]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1021]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1049]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1050]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [538]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1051]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [628]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1052]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Claudin-3 (CLDN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Guanfacine extended release DMB1CZ8 Attention deficit hyperactivity disorder 6A05.Z Approved [1053]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [1054]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1055]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Arsenic DMTL2Y1 N. A. N. A. Approved [1056]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [467]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [509]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1057]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [934]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein RFX5 (RFX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [662]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1058]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [1059]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [1060]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1061]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [1062]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [1063]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [1061]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein P1 (RPLP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1064]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
AHPN DM8G6O4 Discovery agent N.A. Investigative [1065]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1066]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [737]
Diazepam DM08E9O Alcohol withdrawal Approved [475]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [1067]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1068]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1069]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [1070]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [1071]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [1072]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [1072]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Haloperidol DM96SE0 Delirium Approved [614]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [151]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [1073]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [1074]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [671]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1075]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1076]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [1077]
Selenium DM25CGV N. A. N. A. Approved [246]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [595]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [459]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1078]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombomodulin (THBD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [895]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [1079]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1055]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcriptional repressor CTCF (CTCF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [441]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1080]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [950]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1081]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Neuron navigator 3 (NAV3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [342]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [886]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 18 (SLC22A18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [96]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1082]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-interferon-inducible lysosomal thiol reductase (IFI30)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [865]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [1083]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1084]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [1085]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Verapamil DMA7PEW Angina pectoris BA40 Approved [866]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [817]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [177]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [671]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-glucuronidase (GUSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [1086]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [982]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FXYD domain-containing ion transport regulator 3 (FXYD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1087]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [337]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [1088]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [1089]
Raltitrexed DMT9K8G Rectal adenocarcinoma 2B92 Approved [1088]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [873]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome subunit beta type-6 (PSMB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [658]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [421]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [1090]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [499]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [524]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1091]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [1092]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [932]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [533]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1093]
Quercetin DM3NC4M Obesity 5B81 Approved [1094]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome subunit alpha type-4 (PSMA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1095]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [702]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
MG-132 DMKA2YS N. A. N. A. Preclinical [1096]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1014]
AHPN DM8G6O4 Discovery agent N.A. Investigative [1065]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By POM121 and ZP3 fusion protein (POMZP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [18]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [18]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [799]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [897]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 4 (MED4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
Drug(s) Affected By snRNA-activating protein complex subunit 1 (SNAPC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-3(VI) chain (COL6A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1097]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [728]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [602]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1098]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MAP kinase-activated protein kinase 5 (MAPKAPK5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [1099]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1100]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
PMID26560530-Compound-35 DMO36RL N. A. N. A. Patented [1101]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Desmoplakin (DSP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1103]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein mL40 (MRPL40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein uL16 (RPL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [841]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1104]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [392]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1014]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prominin-1 (PROM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [626]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [630]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [886]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [1106]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Probable ATP-dependent RNA helicase DDX23 (DDX23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1107]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coatomer subunit epsilon (COPE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [798]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [950]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [950]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM3C (FAM3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [509]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 134 (TMEM134)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tight junction protein ZO-3 (TJP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [708]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [394]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [394]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
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Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [729]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1109]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [1110]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
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Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor C (CDKN2C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [619]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase copper chaperone (COX17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [428]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [18]
Topotecan DMP6G8T Central nervous system neoplasm Approved [18]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [1111]
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Drug(s) Affected By Trefoil factor 1 (TFF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [1112]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [1113]
Quercetin DM3NC4M Obesity 5B81 Approved [1114]
Estrone DM5T6US Acne vulgaris ED80 Approved [1115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1116]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [1113]
Testosterone DM7HUNW Hot flushes GA30 Approved [1117]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [1118]
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Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1119]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1120]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-1 (ITGA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [855]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1121]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [931]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stathmin (STMN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Quercetin DM3NC4M Obesity 5B81 Approved [880]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1033]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1122]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-adducin (ADD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [539]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [441]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [566]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [729]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Gefitinib DM15F0X Colon adenocarcinoma Approved [310]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1123]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [254]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1124]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [808]
Quercetin DM3NC4M Obesity 5B81 Approved [735]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [1125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1126]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superkiller complex protein 8 (SKIC8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein RFXANK (RFXANK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1011]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Transcription initiation factor TFIID subunit 1 (TAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1080]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1128]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE DMNQL17 Discovery agent N.A. Investigative [1129]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By EF-hand calcium-binding domain-containing protein 7 (EFCAB7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [195]
OXYQUINOLINE DMZVS9Y Discovery agent N.A. Investigative [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucose-6-phosphate isomerase (GPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [780]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Benzatropine DMF7EXL Parkinsonian disorder Approved [614]
Clozapine DMFC71L Schizophrenia 6A20 Approved [614]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTP cyclohydrolase 1 feedback regulatory protein (GCHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1041]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [151]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [198]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [616]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [813]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [13]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [1130]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Selenium DM25CGV N. A. N. A. Approved [246]
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Estrone DM5T6US Acne vulgaris ED80 Approved [684]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1131]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ampicillin DMHWE7P Acute epiglottitis Approved [144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caveolin-1 (CAV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [671]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [689]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1132]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1133]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [93]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1082]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [497]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serglycin (SRGN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1021]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1134]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [254]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [942]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [1135]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Laminin subunit alpha-2 (LAMA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [509]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [509]
Arsenic DMTL2Y1 N. A. N. A. Approved [1136]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Squalene synthase (FDFT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1043]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Fluoxetine DM3PD2C Bipolar depression Approved [1137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytotoxic granule associated RNA binding protein TIA1 (TIA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stanniocalcin-1 (STC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Quercetin DM3NC4M Obesity 5B81 Approved [780]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [336]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ethanol DMDRQZU Chronic pain MG30 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gasdermin-D (GSDMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1140]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [1022]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [696]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [1141]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [1022]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [1142]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [1143]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Desogestrel DM27U4Y Contraception QA21 Approved [1143]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1144]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1145]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1146]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [1147]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1146]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [1147]
Sulfinpyrazone DMEV954 Gout FA25 Approved [1148]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [1146]
Zafirlukast DMHNQOG Asthma CA23 Approved [1146]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [1146]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [1149]
Dabrafenib DMX6OE3 Melanoma 2C30 Approved [1150]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [470]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1151]
Haloperidol DM96SE0 Delirium Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1152]
Selenium DM25CGV N. A. N. A. Approved [1153]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [1154]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [1155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1156]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
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Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1157]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [1110]
Quercetin DM3NC4M Obesity 5B81 Approved [1158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [772]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
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Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1160]
Propranolol DM79NTF Angina pectoris BA40 Approved [1161]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [964]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1162]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Mebendazole DMO14SG Ascariasis 1F62 Approved [1163]
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Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1164]
Etretinate DM2CZFA Keratosis ED56 Approved [727]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1166]
Quercetin DM3NC4M Obesity 5B81 Approved [1167]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [1168]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1169]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [342]
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Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1170]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [619]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
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Drug(s) Affected By Polycystin-2 (PKD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Gentamicin DMKINJO Bacteremia 1A73 Approved [1171]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1002]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [13]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
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Drug(s) Affected By G/T mismatch-specific thymine DNA glycosylase (TDG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Indomethacin DMSC4A7 Bursitis Approved [1172]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
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Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [700]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [13]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [1173]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 168 (TMEM168)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plakophilin-2 (PKP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C chemokine receptor type 6 (CXCR6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Testosterone DM7HUNW Hot flushes GA30 Approved [1174]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [808]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [808]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [1175]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [398]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [398]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 1 (NDUFA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [393]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [997]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [499]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [221]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK2 (PLK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1176]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
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Drug(s) Affected By Galectin-4 (LGALS4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [873]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [13]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [799]
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Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Fluoxetine DM3PD2C Bipolar depression Approved [1137]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [661]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukocyte surface antigen CD47 (CD47)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
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Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [563]
Selenium DM25CGV N. A. N. A. Approved [246]
Epinephrine DM3KJBC Acute asthma CA23 Approved [598]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1177]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [607]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
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Drug(s) Affected By Transcription factor E2F1 (E2F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1178]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [522]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [674]
Gefitinib DM15F0X Colon adenocarcinoma Approved [341]
Selenium DM25CGV N. A. N. A. Approved [246]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [348]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [553]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [1179]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1180]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [1180]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1181]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Selenium DM25CGV N. A. N. A. Approved [246]
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [1182]
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Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase B (PPIB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
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Drug(s) Affected By Annexin A8 (ANXA8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [610]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Benzylpenicillin DMS9503 Actinomycosis Phase 3 [1015]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [103]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
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Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [737]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [509]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [509]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
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Drug(s) Affected By Lysosome-associated membrane glycoprotein 2 (LAMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1183]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [1184]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [1185]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [355]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [1186]
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Drug(s) Affected By Peroxiredoxin-2 (PRDX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1187]
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Quercetin DM3NC4M Obesity 5B81 Approved [1188]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1189]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
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Drug(s) Affected By Hemicentin-1 (HMCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Ethanol DMDRQZU Chronic pain MG30 Approved [1191]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [903]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [405]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1016]
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Drug(s) Affected By Furin (FURIN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [748]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1192]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [423]
KENPAULLONE DMAGVXW Discovery agent N.A. Patented [1193]
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Drug(s) Affected By NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1033]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1194]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1195]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [515]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [1196]
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Drug(s) Affected By Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase (ALG8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
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Drug(s) Affected By Glutathione S-transferase Mu 5 (GSTM5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [547]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1014]
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Drug(s) Affected By Unconventional myosin-Va (MYO5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [880]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [705]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [897]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
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Drug(s) Affected By Integral membrane protein 2B (ITM2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [441]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Arsenic DMTL2Y1 N. A. N. A. Approved [608]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
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Drug(s) Affected By Succinate--CoA ligase subunit beta, mitochondrial (SUCLA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [947]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1197]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [431]
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Drug(s) Affected By Four and a half LIM domains protein 1 (FHL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1198]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Folic Acid DMEMBJC Colorectal carcinoma Approved [887]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [308]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Isoproterenol DMK7MEY Atrioventricular block Approved [1199]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [1200]
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Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [91]
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Quercetin DM3NC4M Obesity 5B81 Approved [1201]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1021]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [607]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
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Drug(s) Affected By Proto-oncogene serine/threonine-protein kinase mos (MOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [702]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [702]
Scriptaid DM9JZ21 Solid tumour/cancer 2A00-2F9Z Preclinical [1203]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [200]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1204]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [840]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [414]
Gefitinib DM15F0X Colon adenocarcinoma Approved [310]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1206]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [813]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [851]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
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Drug(s) Affected By Calcium-activated potassium channel subunit alpha-1 (KCNMA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1207]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1208]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [903]
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Drug(s) Affected By G-protein coupled receptor 35 (GPR35)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1209]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
ZAPRINAST DMGH3T5 N. A. N. A. Terminated [1210]
pamoic acid DM7M5AF Discovery agent N.A. Investigative [1210]
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Drug(s) Affected By Histone deacetylase 9 (HDAC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [200]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [837]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [837]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Indomethacin DMSC4A7 Bursitis Approved [1015]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [1089]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [91]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [490]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [1211]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1212]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [311]
Selenium DM25CGV N. A. N. A. Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [440]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
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Drug(s) Affected By Arginine/serine-rich protein 1 (RSRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1213]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
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Drug(s) Affected By Malectin (MLEC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [410]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
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Drug(s) Affected By Oncostatin-M-specific receptor subunit beta (OSMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [411]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [198]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1214]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Gefitinib DM15F0X Colon adenocarcinoma Approved [800]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Flucytosine DM13VTW Cryptococcal meningitis Approved [189]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [189]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1215]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1216]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [182]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Amifostine DM5FL14 Mucositis CA00 Approved [1217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1218]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Fluoxetine DM3PD2C Bipolar depression Approved [1137]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [1219]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-13 receptor subunit alpha-2 (IL13RA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [728]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [700]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [873]
Arsenic DMTL2Y1 N. A. N. A. Approved [1220]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1221]
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Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [1222]
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Drug(s) Affected By Prostaglandin E synthase 3 (PTGES3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [380]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [1196]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [91]
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Drug(s) Affected By Large ribosomal subunit protein uL23 (RPL23A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Methotrexate DM2TEOL Anterior urethra cancer Approved [18]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [702]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [912]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [431]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
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Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Meclofenamic acid DM05FXR Ankylosing spondylitis FA92.0 Approved [1223]
Diazepam DM08E9O Alcohol withdrawal Approved [1224]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1225]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1223]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1226]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1223]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1097]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
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Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [1227]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Bortezomib DMNO38U Leukemia Approved [308]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [1228]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1227]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Membrane cofactor protein (CD46)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [176]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
ABIRATERONE DM8V75C Prostate cancer 2C82.0 Approved [1229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [1229]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
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Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
L-glutamine DM69G8X Short bowel syndrome KB89.1 Approved [91]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [91]
Quercetin DM3NC4M Obesity 5B81 Approved [950]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
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Drug(s) Affected By Clusterin (CLU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [1230]
Selenium DM25CGV N. A. N. A. Approved [246]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1230]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [503]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [908]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [1230]
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Drug(s) Affected By MAPK/MAK/MRK overlapping kinase (MOK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [209]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1207]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1231]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [18]
Topotecan DMP6G8T Central nervous system neoplasm Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 23 (KRT23)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1232]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 5 (FGF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [600]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [412]
Arsenic DMTL2Y1 N. A. N. A. Approved [691]
Ardeparin DMYRX8B Deep vein thrombosis BD71 Approved [1233]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [922]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1100]
Suramin DMTOUY9 African trypanosomiasis 1F51 Phase 1 [1234]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Epinephrine DM3KJBC Acute asthma CA23 Approved [1235]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [1235]
Norepinephrine DMOUC09 Alopecia ED70 Approved [1235]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [1236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [693]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear body protein SP140 (SP140)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1011]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Drug(s) Affected By Transforming growth factor-beta-induced protein ig-h3 (TGFBI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [337]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [1237]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1238]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase CHFR (CHFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Bortezomib DMNO38U Leukemia Approved [308]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1055]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [1239]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [969]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein mL63 (MRPL57)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Topotecan DMP6G8T Central nervous system neoplasm Approved [18]
Urethane DM7NSI0 N. A. N. A. Phase 4 [422]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1240]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [787]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein CREG1 (CREG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [411]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Arsenic DMTL2Y1 N. A. N. A. Approved [1241]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [313]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [411]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [539]
Quercetin DM3NC4M Obesity 5B81 Approved [655]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinol-binding protein 1 (RBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [1242]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [855]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [982]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [979]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [1243]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [1244]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1245]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [1246]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [438]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [1247]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [1248]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [1248]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arrestin-C (ARR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
Drug(s) Affected By MHC class I polypeptide-related sequence B (MICB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [1249]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1250]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [700]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Latent-transforming growth factor beta-binding protein 2 (LTBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [586]
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [305]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1251]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [409]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lumican (LUM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [315]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [897]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rhotekin (RTKN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [965]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1253]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1254]
Amiloride DMRTSGP Congestive heart failure BD10 Approved [1255]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [366]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [15]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1256]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [660]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [1257]
Methotrexate DM2TEOL Anterior urethra cancer Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1258]
Quercetin DM3NC4M Obesity 5B81 Approved [1259]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1260]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [272]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [219]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1261]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [1262]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1263]
Quercetin DM3NC4M Obesity 5B81 Approved [492]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [934]
Testosterone DM7HUNW Hot flushes GA30 Approved [1264]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [1265]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Mecamylamine DMGQFYB Essential hypertension BA00 Approved [1266]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleophosmin (NPM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [360]
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [655]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1267]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [659]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid beta precursor like protein 2 (APLP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [246]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1044]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [548]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [982]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [402]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [111]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XV) chain (COL15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [728]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [508]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1268]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [823]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1016]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fascin (FSCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1269]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [685]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [544]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1270]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1232]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [878]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [1271]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [983]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A4 (ANXA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [547]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [964]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [252]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [499]
Quercetin DM3NC4M Obesity 5B81 Approved [637]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [1272]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [621]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [499]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1273]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [641]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-acetylgalactosaminyltransferase 7 (GALNT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [18]
Isoflavone DM7U58J N. A. N. A. Phase 4 [1274]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [162]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [787]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Menthol DMG2KW7 Back pain ME84.Z Approved [197]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [706]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial Rho GTPase 2 (RHOT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [707]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Bortezomib DMNO38U Leukemia Approved [308]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [366]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [366]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [200]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Matrilin-2 (MATN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [505]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1276]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [151]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [1277]
Selenium DM25CGV N. A. N. A. Approved [246]
Quercetin DM3NC4M Obesity 5B81 Approved [1278]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [772]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-1-binding protein 1 (ITGB1BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [1227]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [964]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1279]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1280]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [692]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [321]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By U2 small nuclear ribonucleoprotein A' (SNRPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [195]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [128]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [316]
Topotecan DMP6G8T Central nervous system neoplasm Approved [18]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [423]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [950]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1102]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Decorin (DCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1281]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [356]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [728]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [603]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glypican-3 (GPC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1282]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [99]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [1089]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [355]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [476]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1283]
Methotrexate DM2TEOL Anterior urethra cancer Approved [644]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1284]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [762]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [374]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [775]
Ethacrynic acid DM60QMR Edema MG29 Approved [872]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 59 (TMEM59)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [642]
Arsenic DMTL2Y1 N. A. N. A. Approved [608]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [328]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [195]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [337]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Nucleotide triphosphate diphosphatase NUDT15 (NUDT15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [102]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [1285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [18]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1E (MT1E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [729]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [697]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1286]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [1287]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [981]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1288]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [1289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 3 (NDUFA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [428]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [844]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [367]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [327]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [299]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1044]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [207]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1290]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peripheral myelin protein 22 (PMP22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [337]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1291]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [512]
Arsenic DMTL2Y1 N. A. N. A. Approved [1292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [194]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [1265]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [823]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [601]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bone morphogenetic protein 7 (BMP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Folic Acid DMEMBJC Colorectal carcinoma Approved [330]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1055]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [873]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1293]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1294]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [748]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [251]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ferritin light chain (FTL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [617]
Selenium DM25CGV N. A. N. A. Approved [246]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [1046]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [1248]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Ethanol DMDRQZU Chronic pain MG30 Approved [564]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome subunit beta type-1 (PSMB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [656]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [358]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [408]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [1295]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [18]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Procathepsin L (CTSL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [191]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [445]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1296]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [1297]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [1298]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [1296]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor 3 (ARF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [833]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [514]
Arsenic DMTL2Y1 N. A. N. A. Approved [395]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [124]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1299]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [322]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [104]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By V-type proton ATPase catalytic subunit A (ATP6V1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [834]
Leflunomide DMR8ONJ Arthritis FA20 Approved [357]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Testosterone enanthate DMB6871 N. A. N. A. Approved [562]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Clozapine DMFC71L Schizophrenia 6A20 Approved [614]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [150]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [338]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [101]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [246]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [321]
Milchsaure DM462BT Pruritus EC90 Investigative [339]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [1300]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1301]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [1302]
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [1303]
Fenoterol DMIP3ZV Asthma CA23 Approved [1304]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [1305]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [1306]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [1307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [203]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [306]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [309]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [563]
Fluoxetine DM3PD2C Bipolar depression Approved [1137]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [661]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [781]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [376]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [661]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [944]
Testosterone DM7HUNW Hot flushes GA30 Approved [251]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 5 (CXCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [660]
Panobinostat DM58WKG Chronic graft versus host disease Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [247]
Testosterone DM7HUNW Hot flushes GA30 Approved [259]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [100]
Clozapine DMFC71L Schizophrenia 6A20 Approved [1308]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [801]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [407]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1309]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance protein 3 (ABCB4) DTZRMK5 MDR3_HUMAN Substrate [2]
TAP-like protein (ABCB9) DT68UV2 ABCB9_HUMAN Substrate [3]
Multidrug resistance-associated protein 7 (ABCC10) DTPS120 MRP7_HUMAN Substrate [4]
Organic anion transporter 2 (SLC22A7) DT0OC1Q S22A7_HUMAN Substrate [5]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [6]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [7]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [8]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [9]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [10]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [11]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1) OTJISZOX PLCE1_HUMAN Drug Response [13]
14-3-3 protein theta OTWG7F3H 1433T_HUMAN Gene/Protein Processing [14]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Drug Response [15]
4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) OTNWHUJ1 AL9A1_HUMAN Gene/Protein Processing [16]
Abnormal spindle-like microcephaly-associated protein (ASPM) OTKXQMNA ASPM_HUMAN Gene/Protein Processing [17]
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) OTRHPFO2 AN32A_HUMAN Drug Response [18]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [19]
Activated RNA polymerase II transcriptional coactivator p15 (SUB1) OTK71JYU TCP4_HUMAN Gene/Protein Processing [16]
Acyl-coenzyme A thioesterase 8 (ACOT8) OTHY684G ACOT8_HUMAN Gene/Protein Processing [20]
Adenylate cyclase type 6 (ADCY6) OTFOY4WW ADCY6_HUMAN Gene/Protein Processing [21]

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71 FDA Drug Development and Drug Interactions
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98 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
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101 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
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115 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
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118 MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. doi: 10.1002/ijc.21013.
119 Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci. 2008 May;99(5):967-72.
120 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
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123 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
124 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
125 Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
126 Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
127 Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
128 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
129 Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
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132 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
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717 Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
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719 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
720 Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
721 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
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725 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
726 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
727 The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
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729 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
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735 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
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777 Xenobiotic CAR activators induce Dlk1-Dio3 locus noncoding RNA expression in mouse liver. Toxicol Sci. 2017 Aug 1;158(2):367-378.
778 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
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782 Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
783 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
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792 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
793 Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
794 Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem. 2003 May 16;278(20):18092-100. doi: 10.1074/jbc.M300265200. Epub 2003 Mar 13.
795 TNF-related apoptosis-inducing ligand cooperates with NSAIDs via activated Wnt signalling in (pre)malignant colon cells. J Pathol. 2011 Feb;223(3):378-89. doi: 10.1002/path.2797. Epub 2010 Oct 29.
796 Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line. Pharmacol Rep. 2012;64(1):157-65. doi: 10.1016/s1734-1140(12)70742-9.
797 Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 Jun 15;457:152811. doi: 10.1016/j.tox.2021.152811. Epub 2021 May 7.
798 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
799 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
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801 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
802 Up-regulated gene expression of angiogenesis factors in post-chemotherapeutic lung cancer tissues determined by cDNA macroarray. Oncol Rep. 2002 Jul-Aug;9(4):723-8.
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804 Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation. Chem Res Toxicol. 2018 Dec 17;31(12):1418-1425. doi: 10.1021/acs.chemrestox.8b00306. Epub 2018 Nov 9.
805 MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth. Cancer Res. 2004 May 1;64(9):2977-83. doi: 10.1158/0008-5472.can-03-4018.
806 Characterization of arecoline-induced effects on cytotoxicity in normal human gingival fibroblasts by global gene expression profiling. Toxicol Sci. 2007 Nov;100(1):66-74.
807 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
808 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
809 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
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812 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
813 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
814 Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
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816 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
817 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
818 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
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821 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
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825 Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
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892 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
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897 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
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899 Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
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911 Amyloid beta protein-related death-inducing protein induces G2/M arrest: Implications for neurodegeneration in Alzheimer's disease. J Neurosci Res. 2007 Aug 1;85(10):2262-71. doi: 10.1002/jnr.21351.
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925 CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth. PLoS One. 2013 Jun 24;8(6):e66733. doi: 10.1371/journal.pone.0066733. Print 2013.
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965 Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. Mutagenesis. 2014 Jan;29(1):17-26.
966 Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007 Aug;18(7):763-72. doi: 10.1097/CAD.0b013e3280adc905.
967 Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
968 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
969 Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
970 Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol. 2008 Sep;39(3):312-23. doi: 10.1165/rcmb.2008-0012OC. Epub 2008 Apr 17.
971 Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
972 Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
973 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
974 MM-TRAG (MGC4175), a novel intracellular mitochondrial protein, is associated with the taxol- and doxorubicin-resistant phenotype in human cancer cell lines. Gene. 2004 Sep 29;340(1):53-9. doi: 10.1016/j.gene.2004.06.013.
975 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
976 Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
977 Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice. Apoptosis. 2007 Nov;12(11):2077-87. doi: 10.1007/s10495-007-0116-2. Epub 2007 Aug 16.
978 Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells. Toxicol Lett. 2015 Mar 18;233(3):227-38. doi: 10.1016/j.toxlet.2015.01.019. Epub 2015 Jan 30.
979 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
980 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
981 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
982 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
983 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
984 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
985 Essential role of HDAC6 in the regulation of PD-L1 in?melanoma. Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.
986 Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
987 CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis. Cell Biol Toxicol. 2022 Oct;38(5):825-845. doi: 10.1007/s10565-021-09613-0. Epub 2021 May 20.
988 Analysis of nucleotide insertion opposite 2,2,4-triamino-5(2H)-oxazolone by eukaryotic B- and Y-family DNA polymerases. Chem Res Toxicol. 2015 Jun 15;28(6):1307-16. doi: 10.1021/acs.chemrestox.5b00114. Epub 2015 Jun 3.
989 Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity. Chem Res Toxicol. 2013 Feb 18;26(2):221-32. doi: 10.1021/tx300392m. Epub 2013 Jan 31.
990 Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells. Chem Res Toxicol. 2016 Jan 19;29(1):101-8. doi: 10.1021/acs.chemrestox.5b00452. Epub 2015 Dec 30.
991 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
992 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
993 Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins. Bioorg Med Chem. 2011 Aug 15;19(16):4710-20. doi: 10.1016/j.bmc.2011.07.005. Epub 2011 Jul 13.
994 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
995 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
996 Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. doi: 10.4049/jimmunol.1003919. Epub 2011 Jul 18.
997 4-HPR modulates gene expression in ovarian cells. Int J Cancer. 2006 Sep 1;119(5):1005-13. doi: 10.1002/ijc.21797.
998 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
999 Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017 Oct;24:147-158. doi: 10.1016/j.ebiom.2017.09.022. Epub 2017 Sep 19.
1000 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
1001 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
1002 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
1003 Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26.
1004 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
1005 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
1006 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
1007 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
1008 GRIM?19?mediated Stat3 activation is a determinant for resveratrol?induced proliferation and cytotoxicity in cervical tumor?derived cell lines. Mol Med Rep. 2015 Feb;11(2):1272-7. doi: 10.3892/mmr.2014.2797. Epub 2014 Oct 29.
1009 Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
1010 Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
1011 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
1012 In vitro gene expression data supporting a DNA non-reactive genotoxic mechanism for ochratoxin A. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):216-24.
1013 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
1014 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
1015 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
1016 Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
1017 Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides. Cancer Res. 2007 Jul 1;67(13):6400-8. doi: 10.1158/0008-5472.CAN-07-0251.
1018 Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. Br J Cancer. 2008 Sep 2;99(5):760-7. doi: 10.1038/sj.bjc.6604528.
1019 Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
1020 Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B. Sci Rep. 2018 Jun 29;8(1):9877. doi: 10.1038/s41598-018-27995-w.
1021 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
1022 Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
1023 Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
1024 DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
1025 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
1026 Calcipotriol induces autophagy in HeLa cells and keratinocytes. J Invest Dermatol. 2011 Apr;131(4):990-3. doi: 10.1038/jid.2010.423. Epub 2011 Jan 13.
1027 Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
1028 The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. Int J Cancer. 2011 Apr 1;128(7):1712-23. doi: 10.1002/ijc.25477. Epub 2010 May 25.
1029 Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicol Appl Pharmacol. 2017 Mar 15;319:1-11. doi: 10.1016/j.taap.2017.01.016. Epub 2017 Jan 25.
1030 Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. Toxicol Mech Methods. 2012 Sep;22(7):512-9. doi: 10.3109/15376516.2012.686534. Epub 2012 May 22.
1031 Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
1032 Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
1033 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
1034 White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
1035 Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells. Oncotarget. 2016 Aug 9;7(32):52392-52403.
1036 MARVELD1 attenuates arsenic trioxide-induced apoptosis in liver cancer cells by inhibiting reactive oxygen species production. Ann Transl Med. 2019 May;7(9):200. doi: 10.21037/atm.2019.04.38.
1037 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
1038 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
1039 Akt and XIAP regulate the sensitivity of human uterine cancer cells to cisplatin, doxorubicin and taxol. Apoptosis. 2008 Feb;13(2):259-71. doi: 10.1007/s10495-007-0165-6.
1040 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
1041 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
1042 Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
1043 Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62.
1044 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
1045 Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
1046 Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
1047 Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
1048 [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
1049 Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res. 2001 Oct;92(10):1133-7. doi: 10.1111/j.1349-7006.2001.tb01069.x.
1050 HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
1051 Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
1052 Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
1053 Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflamm Bowel Dis. 2019 May 4;25(6):1006-1018. doi: 10.1093/ibd/izz017.
1054 Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact. 2009 May 15;179(2-3):185-91. doi: 10.1016/j.cbi.2008.11.009. Epub 2008 Nov 21.
1055 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
1056 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
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1058 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
1059 Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study. Am Heart J. 2006 Jan;151(1):139. doi: 10.1016/j.ahj.2005.10.006.
1060 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
1061 Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients. Diabetes Care. 2006 Feb;29(2):195-201. doi: 10.2337/diacare.29.02.06.dc05-1418.
1062 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
1063 Eptifibatide in peripheral vascular interventions: results of the Integrilin Reduces Inflammation in Peripheral Vascular Interventions (INFLAME) trial. J Invasive Cardiol. 2006 Jan;18(1):6-12.
1064 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
1065 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
1066 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
1067 Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
1068 Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
1069 The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adipose-derived stromal cells and platelet-rich plasma. Biomaterials. 2010 Jul;31(20):5325-35. doi: 10.1016/j.biomaterials.2010.03.037. Epub 2010 Apr 9.
1070 Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
1071 The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
1072 Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
1073 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
1074 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
1075 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
1076 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
1077 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
1078 Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):231-8. doi: 10.1016/j.taap.2009.02.003. Epub 2009 Feb 12.
1079 Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives. Thromb Haemost. 1996 Nov;76(5):729-34.
1080 Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
1081 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
1082 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
1083 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
1084 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
1085 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
1086 Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors. J Immunol. 2001 Mar 15;166(6):4083-91.
1087 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
1088 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
1089 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
1090 Biochemical and toxicological evaluation of nano-heparins in cell functional properties, proteasome activation and expression of key matrix molecules. Toxicol Lett. 2016 Jan 5;240(1):32-42. doi: 10.1016/j.toxlet.2015.10.005. Epub 2015 Oct 22.
1091 Crosstalk between alveolar macrophages and alveolar epithelial cells/fibroblasts contributes to the pulmonary toxicity of gefitinib. Toxicol Lett. 2021 Mar 1;338:1-9. doi: 10.1016/j.toxlet.2020.11.011. Epub 2020 Nov 25.
1092 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
1093 Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulating monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002 Jul 1;22(7):1194-9. doi: 10.1161/01.atv.0000022694.16328.cc.
1094 Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFB and AhR and EGFR-ERK pathway. Toxicol Appl Pharmacol. 2011 Sep 1;255(2):138-49.
1095 Changes in composition and activities of 26S proteasomes under the action of doxorubicin--apoptosis inductor of erythroleukemic K562 cells. Cell Biol Int. 2007 Apr;31(4):338-48. doi: 10.1016/j.cellbi.2007.01.018. Epub 2007 Jan 21.
1096 Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity. J Biol Chem. 2020 Jan 31;295(5):1271-1287. doi: 10.1074/jbc.RA119.011174. Epub 2019 Dec 5.
1097 Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
1098 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
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1100 A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
1101 Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
1102 Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
1103 Cytosolic proteomic alterations in the nucleus accumbens of cocaine overdose victims. Mol Psychiatry. 2007 Jan;12(1):55-73. doi: 10.1038/sj.mp.4001914. Epub 2006 Oct 31.
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1107 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
1108 Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
1109 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
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1118 Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Res Treat. 2009 Aug;116(3):461-70. doi: 10.1007/s10549-008-0151-x. Epub 2008 Aug 3.
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1120 E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
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1123 Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
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1125 The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
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1127 Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation. Cancer Res. 2007 Apr 1;67(7):3229-38. doi: 10.1158/0008-5472.CAN-06-2759.
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1130 Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Ther. 2005 Feb;4(2):233-41.
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1135 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
1136 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
1137 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
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1139 Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
1140 CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
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1155 Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
1156 The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
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1160 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
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1164 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
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1173 Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
1174 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
1175 The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation. Biosci Rep. 2008 Jun;28(3):161-76. doi: 10.1042/BSR20080046.
1176 The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma. Mol Cancer Ther. 2007 Apr;6(4):1300-9.
1177 Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):834-840. doi: 10.1016/j.bbrc.2019.04.081. Epub 2019 Apr 16.
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1182 Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12.
1183 Pyrroloquinoline quinine ameliorates doxorubicin-induced autophagy-dependent apoptosis via lysosomal-mitochondrial axis in vascular endothelial cells. Toxicology. 2019 Sep 1;425:152238. doi: 10.1016/j.tox.2019.152238. Epub 2019 Jun 18.
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1192 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Osteoarthritis Cartilage. 2010 Mar;18(3):455-63. doi: 10.1016/j.joca.2009.10.014. Epub 2009 Nov 4.
1193 A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
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1195 Antineoplastic effects of decitabine, an inhibitor of DNA promoter methylation, in adrenocortical carcinoma cells. Arch Surg. 2010 Mar;145(3):226-32. doi: 10.1001/archsurg.2009.292.
1196 Proteomic analysis of liver cancer cells treated with suberonylanilide hydroxamic acid. Cancer Chemother Pharmacol. 2008 Apr;61(5):791-802.
1197 Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
1198 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
1199 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
1200 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
1201 Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Toxicol Mech Methods. 2023 Feb;33(2):141-150. doi: 10.1080/15376516.2022.2103480. Epub 2022 Aug 9.
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1203 Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. Int J Oncol. 2008 Oct;33(4):767-76.
1204 Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
1205 The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
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1208 Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes. Steroids. 2008 Mar;73(3):272-9. doi: 10.1016/j.steroids.2007.10.010. Epub 2007 Nov 4.
1209 Identification of novel genes associated with the response to 5-FU treatment in gastric cancer cell lines using a cDNA microarray. Cancer Lett. 2004 Oct 8;214(1):19-33.
1210 Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95. doi: 10.1124/jpet.112.198945. Epub 2012 Sep 11.
1211 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
1212 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
1213 Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
1214 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
1215 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
1216 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
1217 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
1218 Simvastatin modulates the Alzheimer's disease-related gene seladin-1. J Alzheimers Dis. 2012;28(2):297-301.
1219 Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells. Anticancer Res. 2006 Sep-Oct;26(5A):3205-15.
1220 Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
1221 Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
1222 Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate. Chem Res Toxicol. 2019 Dec 16;32(12):2526-2537. doi: 10.1021/acs.chemrestox.9b00358. Epub 2019 Nov 11.
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1224 Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
1225 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
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1238 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
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