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Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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Vigabatrin versus carbamazepine and phenytoin in kainic acid-treated pubescent rats.Pharmacol Res. 1997 Aug;36(2):87-93. doi: 10.1006/phrs.1997.0184.
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ADAM9, ADAM10, and ADAM15 mRNA levels in the rat brain after kainic acid-induced status epilepticus.Brain Res Mol Brain Res. 2005 Jun 13;137(1-2):272-5. doi: 10.1016/j.molbrainres.2005.03.008. Epub 2005 Apr 20.
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Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.Pharmacol Biochem Behav. 2010 Mar;95(1):88-91. doi: 10.1016/j.pbb.2009.12.011. Epub 2009 Dec 21.
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Status epilepticus in mice deficient for succinate semialdehyde dehydrogenase: GABAA receptor-mediated mechanisms.Ann Neurol. 2006 Jan;59(1):42-52. doi: 10.1002/ana.20686.
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Immunohistochemical study of p53-associated proteins in rat brain following lithium-pilocarpine status epilepticus.Brain Res. 2002 Mar 1;929(1):129-38. doi: 10.1016/s0006-8993(01)03360-1.
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Differential expressions of aquaporin subtypes in astroglia in the hippocampus of chronic epileptic rats.Neuroscience. 2009 Oct 20;163(3):781-9. doi: 10.1016/j.neuroscience.2009.07.028. Epub 2009 Jul 18.
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Peroxisome proliferator-activated receptors /mitochondrial uncoupling protein 2 signaling protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus.J Neuroinflammation. 2012 Jul 31;9:184. doi: 10.1186/1742-2094-9-184.
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The effect of STAT3 inhibition on status epilepticus and subsequent spontaneous seizures in the pilocarpine model of acquired epilepsy.Neurobiol Dis. 2014 Feb;62:73-85. doi: 10.1016/j.nbd.2013.09.003. Epub 2013 Sep 16.
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Increased expression of caspase 2 in experimental and human temporal lobe epilepsy.Neuromolecular Med. 2007;9(2):129-44. doi: 10.1007/BF02685887.
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Caspase 6 expression in the rat hippocampus during epileptogenesis and epilepsy.Neuroscience. 2005;131(4):887-97. doi: 10.1016/j.neuroscience.2004.12.013.
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Characterization of the expression of macrophage inflammatory protein-1 (MIP-1) and C-C chemokine receptor 5 (CCR5) after kainic acid-induced status epilepticus (SE) in juvenile rats.Neuropathol Appl Neurobiol. 2012 Oct;38(6):602-16. doi: 10.1111/j.1365-2990.2012.01251.x.
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Blood plasma inflammation markers during epileptogenesis in post-status epilepticus rat model for temporal lobe epilepsy.Epilepsia. 2013 Apr;54(4):589-95. doi: 10.1111/epi.12112. Epub 2013 Feb 8.
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The roles of fractalkine/CX3CR1 system in neuronal death following pilocarpine-induced status epilepticus.J Neuroimmunol. 2011 May;234(1-2):93-102. doi: 10.1016/j.jneuroim.2011.03.005. Epub 2011 Apr 8.
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Increased expression of the chemokines CXCL1 and MIP-1 by resident brain cells precedes neutrophil infiltration in the brain following prolonged soman-induced status epilepticus in rats.J Neuroinflammation. 2011 May 2;8:41. doi: 10.1186/1742-2094-8-41.
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Region-specific plasticity in the epileptic rat brain: a hippocampal and extrahippocampal analysis.Epilepsia. 2009 Mar;50(3):537-49. doi: 10.1111/j.1528-1167.2008.01718.x. Epub 2008 Nov 20.
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Endogenous neurosteroids modulate epileptogenesis in a model of temporal lobe epilepsy.Exp Neurol. 2006 Oct;201(2):519-24. doi: 10.1016/j.expneurol.2006.04.029. Epub 2006 Jun 14.
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Acylated ghrelin protects hippocampal neurons in pilocarpine-induced seizures of immature rats by inhibiting cell apoptosis.Mol Biol Rep. 2013 Jan;40(1):51-8. doi: 10.1007/s11033-012-1993-1. Epub 2012 Nov 6.
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Connexin-30 mRNA is up-regulated in astrocytes and expressed in apoptotic neuronal cells of rat brain following kainate-induced seizures.Mol Cell Neurosci. 2002 Sep;21(1):94-113. doi: 10.1006/mcne.2002.1155.
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GluR5 kainate receptors, seizures, and the amygdala.Ann N Y Acad Sci. 2003 Apr;985:150-62. doi: 10.1111/j.1749-6632.2003.tb07079.x.
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Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy.Brain Res. 2011 Dec 2;1426:86-95. doi: 10.1016/j.brainres.2011.10.006. Epub 2011 Oct 8.
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The protective effects of interleukin-18 and interferon- on neuronal damages in the rat hippocampus following status epilepticus.Neuroscience. 2010 Oct 27;170(3):711-21. doi: 10.1016/j.neuroscience.2010.07.048. Epub 2010 Jul 29.
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Regulation of Kir4.1 expression in astrocytes and astrocytic tumors: a role for interleukin-1 .J Neuroinflammation. 2012 Dec 28;9:280. doi: 10.1186/1742-2094-9-280.
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Region-specific alterations in astroglial TWIK-related acid-sensitive K+-1 channel immunoreactivity in the rat hippocampal complex following pilocarpine-induced status epilepticus.J Comp Neurol. 2008 Oct 10;510(5):463-74. doi: 10.1002/cne.21767.
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Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.Transl Psychiatry. 2017 Mar 7;7(3):e1052. doi: 10.1038/tp.2017.20.
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Neuroprotective Effects of the Absence of JNK1 or JNK3 Isoforms on Kainic Acid-Induced Temporal Lobe Epilepsy-Like Symptoms.Mol Neurobiol. 2018 May;55(5):4437-4452. doi: 10.1007/s12035-017-0669-1. Epub 2017 Jun 29.
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[Number changes and axonal sprouting of neuropeptide Y interneurons in the hippocampus of pilocarpine-induced rats].Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Feb;34(2):93-8.
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Alleviation of Oxidative Damage and Involvement of Nrf2-ARE Pathway in Mesodopaminergic System and Hippocampus of Status Epilepticus Rats Pretreated by Intranasal Pentoxifylline.Oxid Med Cell Longev. 2017;2017:7908072. doi: 10.1155/2017/7908072. Epub 2017 Mar 12.
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Ontogenetic profile of ectonucleotidase activities from brain synaptosomes of pilocarpine-treated rats.Int J Dev Neurosci. 2005 Dec;23(8):703-9. doi: 10.1016/j.ijdevneu.2005.09.001. Epub 2005 Nov 4.
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Mitochondrial DNA damage and impaired base excision repair during epileptogenesis.Neurobiol Dis. 2008 Apr;30(1):130-8. doi: 10.1016/j.nbd.2007.12.009. Epub 2008 Jan 5.
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Increased expression of placental growth factor in patients with temporal lobe epilepsy and a rat model.Brain Res. 2012 Jan 6;1429:124-33. doi: 10.1016/j.brainres.2011.10.008. Epub 2011 Oct 6.
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Increased expression and activity of urokinase-type plasminogen activator during epileptogenesis.Eur J Neurosci. 2006 Oct;24(7):1935-45. doi: 10.1111/j.1460-9568.2006.05062.x. Epub 2006 Oct 16.
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Expression of urokinase-type plasminogen activator receptor is increased during epileptogenesis in the rat hippocampus.Neuroscience. 2009 Sep 29;163(1):316-28. doi: 10.1016/j.neuroscience.2009.06.019. Epub 2009 Jun 12.
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Expression of different isoforms of protein kinase C in the rat hippocampus after pilocarpine-induced status epilepticus with special reference to CA1 area and the dentate gyrus.Hippocampus. 2004;14(1):87-98. doi: 10.1002/hipo.10156.
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Selective alterations of glycosaminoglycans synthesis and proteoglycan expression in rat cortex and hippocampus in pilocarpine-induced epilepsy.Brain Res Bull. 1999 Nov 1;50(4):229-39. doi: 10.1016/s0361-9230(99)00195-1.
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Neonatal status epilepticus alters prefrontal-striatal circuitry and enhances methamphetamine-induced behavioral sensitization in adolescence.Epilepsy Behav. 2009 Feb;14(2):316-23. doi: 10.1016/j.yebeh.2008.12.005. Epub 2009 Jan 4.
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Regulation of Synaptosomal GLT-1 and GLAST during Epileptogenesis.Neuroscience. 2019 Jul 15;411:185-201. doi: 10.1016/j.neuroscience.2019.05.048. Epub 2019 May 31.
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Effects of creatine and -guanidinopropionic acid and alterations in creatine transporter and creatine kinases expression in acute seizure and chronic epilepsy models.BMC Neurosci. 2010 Oct 28;11:141. doi: 10.1186/1471-2202-11-141.
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Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines.Neuroscience. 2003;122(2):349-58. doi: 10.1016/s0306-4522(03)00594-3.
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Expression of the multidrug transporter MRP2 in the blood-brain barrier after pilocarpine-induced seizures in rats.Epilepsy Res. 2006 Apr;69(1):1-14. doi: 10.1016/j.eplepsyres.2005.12.005. Epub 2006 Feb 28.
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Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E.Biochem Biophys Res Commun. 2009 Feb 20;379(4):949-53. doi: 10.1016/j.bbrc.2008.12.178. Epub 2009 Jan 10.
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Protective effect of the organotelluroxetane RF-07 in pilocarpine-induced status epilepticus.Neurobiol Dis. 2008 Jul;31(1):120-6. doi: 10.1016/j.nbd.2008.04.001. Epub 2008 Apr 23.
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Increase in tyrosine phosphorylation of the NMDA receptor following the induction of status epilepticus.Neurosci Lett. 2006 Jul 3;401(3):266-70. doi: 10.1016/j.neulet.2006.03.033. Epub 2006 Apr 4.
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Blockade of the sodium calcium exchanger exhibits anticonvulsant activity in a pilocarpine model of acute seizures in rats.Brain Res. 2010 Dec 17;1366:211-6. doi: 10.1016/j.brainres.2010.09.100. Epub 2010 Oct 1.
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The expression of somatostatin receptors in the hippocampus of pilocarpine-induced rat epilepsy model.Neuropeptides. 2008 Oct-Dec;42(5-6):569-83. doi: 10.1016/j.npep.2008.09.002. Epub 2008 Oct 31.
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Post-treatment with the GLP-1 analogue liraglutide alleviate chronic inflammation and mitochondrial stress induced by Status epilepticus.Epilepsy Res. 2018 May;142:45-52. doi: 10.1016/j.eplepsyres.2018.03.009. Epub 2018 Mar 9.
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Phosphorylation of the alpha subunit of translation initiation factor-2 by PKR mediates protein synthesis inhibition in the mouse brain during status epilepticus.Biochem J. 2006 Jul 1;397(1):187-94. doi: 10.1042/BJ20051643.
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-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus.Ann Neurol. 2020 Jan;87(1):84-96. doi: 10.1002/ana.25635. Epub 2019 Nov 20.
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AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders. Nat Commun. 2019 Jul 12;10(1):3094. doi: 10.1038/s41467-019-10910-w.
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Functional role of mGluR1 and mGluR4 in pilocarpine-induced temporal lobe epilepsy.Neurobiol Dis. 2007 Jun;26(3):623-33. doi: 10.1016/j.nbd.2007.03.003. Epub 2007 Mar 16.
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Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake.J Neurosci. 2019 Jan 23;39(4):727-742. doi: 10.1523/JNEUROSCI.1148-18.2018. Epub 2018 Nov 30.
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Novel clinical manifestations in patients with KCNA2 mutations.Seizure. 2017 Oct;51:74-76. doi: 10.1016/j.seizure.2017.07.018. Epub 2017 Aug 5.
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Modulatory effect of opioid ligands on status epilepticus and the role of nitric oxide pathway.Epilepsy Behav. 2019 Dec;101(Pt A):106563. doi: 10.1016/j.yebeh.2019.106563. Epub 2019 Oct 30.
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Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.Sci Signal. 2019 Oct 15;12(603):eaaw9315. doi: 10.1126/scisignal.aaw9315.
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Glibenclamide ameliorates cerebral edema and improves outcomes in a rat model of status epilepticus.Neuropharmacology. 2017 Jul 15;121:1-11. doi: 10.1016/j.neuropharm.2017.04.016. Epub 2017 Apr 13.
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Cytosolic phospholipase A2 is a key regulator of blood-brain barrier function in epilepsy.FASEB J. 2019 Dec;33(12):14281-14295. doi: 10.1096/fj.201901369RR. Epub 2019 Oct 29.
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Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital.J Pharmacol Toxicol Methods. 2019 May-Jun;97:1-12. doi: 10.1016/j.vascn.2019.02.006. Epub 2019 Feb 19.
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Regulation of ADAM10 by MicroRNA-23a Contributes to Epileptogenesis in Pilocarpine-Induced Status Epilepticus Mice.Front Cell Neurosci. 2019 Apr 30;13:180. doi: 10.3389/fncel.2019.00180. eCollection 2019.
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Increased metalloproteinase activity in the hippocampus following status epilepticus.Epilepsy Res. 2017 May;132:50-58. doi: 10.1016/j.eplepsyres.2017.02.021. Epub 2017 Mar 1.
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Role of adenosine in status epilepticus: a potential new target?.Epilepsia. 2013 Sep;54 Suppl 6(0 6):20-2. doi: 10.1111/epi.12268.
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Effect of adenovirus-mediated overexpression of PTEN on brain oxidative damage and neuroinflammation in a rat kindling model of epilepsy.Chin Med J (Engl). 2019 Nov 5;132(21):2628-2635. doi: 10.1097/CM9.0000000000000496.
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Altered Expression Pattern of Acid-Sensing Ion Channel Isoforms in Piriform Cortex After Seizures.Mol Neurobiol. 2016 Apr;53(3):1782-1793. doi: 10.1007/s12035-015-9130-5. Epub 2015 Mar 7.
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Status epilepticus induced by pilocarpine and Ca2+ transport by microsome in the hippocampus of rats.Neurosci Lett. 2004 Aug 19;366(3):292-6. doi: 10.1016/j.neulet.2004.05.052.
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Interaction of GABA(A) and GABA(B) antagonists after status epilepticus in immature rats.Epilepsy Behav. 2020 Jan;102:106683. doi: 10.1016/j.yebeh.2019.106683. Epub 2019 Nov 21.
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TrkB-Shc Signaling Protects against Hippocampal Injury Following Status Epilepticus.J Neurosci. 2019 Jun 5;39(23):4624-4630. doi: 10.1523/JNEUROSCI.2939-18.2019. Epub 2019 Mar 29.
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Resveratrol Promotes Mitochondrial Biogenesis and Protects against Seizure-Induced Neuronal Cell Damage in the Hippocampus Following Status Epilepticus by Activation of the PGC-1 Signaling Pathway.Int J Mol Sci. 2019 Feb 25;20(4):998. doi: 10.3390/ijms20040998.
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Anticonvulsant effect of argan oil on pilocarpine model induced status epilepticus in wistar rats.Nutr Neurosci. 2018 Feb;21(2):116-122. doi: 10.1080/1028415X.2016.1228492. Epub 2016 Sep 12.
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Annexin A1-derived peptide Ac(2-26) in a pilocarpine-induced status epilepticus model: anti-inflammatory and neuroprotective effects.J Neuroinflammation. 2019 Feb 12;16(1):32. doi: 10.1186/s12974-019-1414-7.
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CCR3, CCR2A and macrophage inflammatory protein (MIP)-1a, monocyte chemotactic protein-1 (MCP-1) in the mouse hippocampus during and after pilocarpine-induced status epilepticus (PISE).Neuropathol Appl Neurobiol. 2009 Oct;35(5):496-514. doi: 10.1111/j.1365-2990.2009.01022.x.
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CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus.J Neurochem. 2007 Feb;100(4):1072-88. doi: 10.1111/j.1471-4159.2006.04272.x. Epub 2007 Dec 20.
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Peroxisome proliferator-activated receptor gamma agonist, rosiglitazone, suppresses CD40 expression and attenuates inflammatory responses after lithium pilocarpine-induced status epilepticus in rats.Int J Dev Neurosci. 2008 Aug;26(5):505-15. doi: 10.1016/j.ijdevneu.2008.01.009. Epub 2008 Mar 29.
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Neural (N-) cadherin, a synaptic adhesion molecule, is induced in hippocampal mossy fiber axonal sprouts by seizure.J Neurosci Res. 2002 Aug 1;69(3):292-304. doi: 10.1002/jnr.10305.
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Altered Synaptic Drive onto Birthdated Dentate Granule Cells in Experimental Temporal Lobe Epilepsy.J Neurosci. 2019 Sep 18;39(38):7604-7614. doi: 10.1523/JNEUROSCI.0654-18.2019. Epub 2019 Jul 3.
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Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet.Epilepsia. 2018 Jan;59(1):79-91. doi: 10.1111/epi.13950. Epub 2017 Nov 24.
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Peptide-induced infant status epilepticus causes neuronal death and synaptic reorganization.Neuroreport. 1995 Jan 26;6(2):277-80. doi: 10.1097/00001756-199501000-00013.
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Targeting PSD95-nNOS interaction by Tat-N-dimer peptide during status epilepticus is neuroprotective in MAM-pilocarpine rat model.Neuropharmacology. 2019 Jul 15;153:82-97. doi: 10.1016/j.neuropharm.2019.04.028. Epub 2019 Apr 29.
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The Regional Specific Alterations in BBB Permeability are Relevant to the Differential Responses of 67-kDa LR Expression in Endothelial Cells and Astrocytes Following Status Epilepticus.Int J Mol Sci. 2019 Nov 29;20(23):6025. doi: 10.3390/ijms20236025.
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Lacosamide modulates collapsin response mediator protein 2 and inhibits mossy fiber sprouting after kainic acid-induced status epilepticus.Neuroreport. 2018 Nov 7;29(16):1384-1390. doi: 10.1097/WNR.0000000000001123.
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miRNA-187-3p-Mediated Regulation of the KCNK10/TREK-2 Potassium Channel in a Rat Epilepsy Model.ACS Chem Neurosci. 2016 Nov 16;7(11):1585-1594. doi: 10.1021/acschemneuro.6b00222. Epub 2016 Sep 22.
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Erythropoietin and Nrf2: key factors in the neuroprotection provided by apo-lactoferrin.Biometals. 2018 Jun;31(3):425-443. doi: 10.1007/s10534-018-0111-9. Epub 2018 May 10.
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Inhibition of protease-activated receptor 1 ameliorates behavioral deficits and restores hippocampal synaptic plasticity in a rat model of status epilepticus.Neurosci Lett. 2019 Jan 23;692:64-68. doi: 10.1016/j.neulet.2018.10.058. Epub 2018 Nov 1.
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GPR40 modulates epileptic seizure and NMDA receptor function.Sci Adv. 2018 Oct 17;4(10):eaau2357. doi: 10.1126/sciadv.aau2357. eCollection 2018 Oct.
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Cyclooxygenase-2 inhibitor inhibits hippocampal synaptic reorganization in pilocarpine-induced status epilepticus rats.J Zhejiang Univ Sci B. 2008 Nov;9(11):903-15. doi: 10.1631/jzus.B0820018.
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Effects of galanin receptor 2 and receptor 3 knockout in mouse models of acute seizures.Epilepsia. 2018 Nov;59(11):e166-e171. doi: 10.1111/epi.14573. Epub 2018 Oct 8.
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The Role of 5-HTR6 in Mossy Fiber Sprouting: Activating Fyn and p-ERK1/2 in Pilocarpine-Induced Chronic Epileptic Rats.Cell Physiol Biochem. 2017;42(1):231-241. doi: 10.1159/000477322. Epub 2017 May 25.
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[Expressions of GDNF, GDNFR alpha and Ret proteins in the brain of rats with seizures induced by pilocarpine].Beijing Da Xue Xue Bao Yi Xue Ban. 2003 Jun 18;35(3):296-8.
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Alteration of Gene Associated with Retinoid-interferon-induced Mortality-19-expressing Cell Types in the Mouse Hippocampus Following Pilocarpine-induced Status Epilepticus.Neuroscience. 2020 Jan 15;425:49-58. doi: 10.1016/j.neuroscience.2019.11.015. Epub 2019 Nov 29.
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The novel GLP-1/GIP dual receptor agonist DA3-CH is neuroprotective in the pilocarpine-induced epileptogenesis rat model.Epilepsy Res. 2019 Aug;154:97-106. doi: 10.1016/j.eplepsyres.2019.05.008. Epub 2019 May 8.
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Cx36 in the mouse hippocampus during and after pilocarpine-induced status epilepticus.Epilepsy Res. 2018 Mar;141:64-72. doi: 10.1016/j.eplepsyres.2018.02.007. Epub 2018 Feb 17.
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The Neuroprotective Effect of Astaxanthin on Pilocarpine-Induced Status Epilepticus in Rats.Front Cell Neurosci. 2019 Mar 29;13:123. doi: 10.3389/fncel.2019.00123. eCollection 2019.
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Blockade of GluN2B-containing NMDA receptors reduces short-term brain damage induced by early-life status epilepticus.Neurotoxicology. 2019 Mar;71:138-149. doi: 10.1016/j.neuro.2019.01.002. Epub 2019 Jan 11.
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The Phosphodiesterase 10A Inhibitor PF-2545920 Enhances Hippocampal Excitability and Seizure Activity Involving the Upregulation of GluA1 and NR2A in Post-synaptic Densities.Front Mol Neurosci. 2017 Apr 7;10:100. doi: 10.3389/fnmol.2017.00100. eCollection 2017.
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The expression of G protein-coupled receptor kinase 5 and its interaction with dendritic marker microtubule-associated protein-2 after status epilepticus.Epilepsy Res. 2017 Dec;138:62-70. doi: 10.1016/j.eplepsyres.2017.10.011. Epub 2017 Oct 13.
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Progranulin and Its Related MicroRNAs after Status Epilepticus: Possible Mechanisms of Neuroprotection.Int J Mol Sci. 2017 Feb 24;18(3):490. doi: 10.3390/ijms18030490.
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Bi-directional genetic modulation of GSK-3 exacerbates hippocampal neuropathology in experimental status epilepticus.Cell Death Dis. 2018 Sep 20;9(10):969. doi: 10.1038/s41419-018-0963-5.
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Rapid loss of dendritic HCN channel expression in hippocampal pyramidal neurons following status epilepticus.J Neurosci. 2011 Oct 5;31(40):14291-5. doi: 10.1523/JNEUROSCI.1148-11.2011.
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Effect of status epilepticus on expression of brain UDP-glucuronosyltransferase 1a in rats.Biopharm Drug Dispos. 2018 Feb;39(2):75-82. doi: 10.1002/bdd.2114. Epub 2017 Dec 21.
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The Neuroprotective Effects of Histamine H3 Receptor Antagonist E177 on Pilocarpine-Induced Status Epilepticus in Rats.Molecules. 2019 Nov 14;24(22):4106. doi: 10.3390/molecules24224106.
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The impact of postsynaptic density 95 blocking peptide (Tat-NR2B9c) and an iNOS inhibitor (1400W) on proteomic profile of the hippocampus in C57BL/6J mouse model of kainate-induced epileptogenesis.J Neurosci Res. 2019 Nov;97(11):1378-1392. doi: 10.1002/jnr.24441. Epub 2019 May 15.
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Interleukin-1 increases neuronal death in the hippocampal dentate gyrus associated with status epilepticus in the developing rat.Neurologia. 2017 Nov-Dec;32(9):587-594. doi: 10.1016/j.nrl.2016.03.013. Epub 2016 Jun 11.
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Distinctive rat brain immediate early gene responses to seizures induced by lithium plus pilocarpine.Brain Res Mol Brain Res. 1994 Aug;25(1-2):80-9. doi: 10.1016/0169-328x(94)90281-x.
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Chronic deficit in the expression of voltage-gated potassium channel Kv3.4 subunit in the hippocampus of pilocarpine-treated epileptic rats.Brain Res. 2011 Jan 12;1368:308-16. doi: 10.1016/j.brainres.2010.10.047. Epub 2010 Oct 21.
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Prolonged seizure activity causes caspase dependent cleavage and dysfunction of G-protein activated inwardly rectifying potassium channels.Sci Rep. 2017 Sep 26;7(1):12313. doi: 10.1038/s41598-017-12508-y.
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Deficit of Kcnma1 mRNA expression in the dentate gyrus of epileptic rats.Neuroreport. 2008 Aug 27;19(13):1291-4. doi: 10.1097/WNR.0b013e3283094bb6.
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Attenuating M-current suppression in vivo by a mutant Kcnq2 gene knock-in reduces seizure burden and prevents status epilepticus-induced neuronal death and epileptogenesis.Epilepsia. 2018 Oct;59(10):1908-1918. doi: 10.1111/epi.14541. Epub 2018 Aug 26.
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Vitamin E inhibits activated chaperone-mediated autophagy in rats with status epilepticus.Neuroscience. 2009 Jun 16;161(1):73-7. doi: 10.1016/j.neuroscience.2009.02.059. Epub 2009 Mar 9.
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Inflammation and reactive oxygen species in status epilepticus: Biomarkers and implications for therapy.Epilepsy Behav. 2019 Dec;101(Pt B):106275. doi: 10.1016/j.yebeh.2019.04.028. Epub 2019 Jun 4.
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Zinc regulates a key transcriptional pathway for epileptogenesis via metal-regulatory transcription factor 1.Nat Commun. 2015 Oct 26;6:8688. doi: 10.1038/ncomms9688.
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Attenuation of pentylenetrazole-induced acute status epilepticus in rats by adenosine involves inhibition of the mammalian target of rapamycin pathway.Neuroreport. 2017 Oct 18;28(15):1016-1021. doi: 10.1097/WNR.0000000000000878.
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Change in neurotrophins and their receptor mRNAs in the rat forebrain after status epilepticus induced by pilocarpine.Epilepsia. 1996 Feb;37(2):198-207. doi: 10.1111/j.1528-1157.1996.tb00012.x.
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Triheptanoin protects against status epilepticus-induced hippocampal mitochondrial dysfunctions, oxidative stress and neuronal degeneration.J Neurochem. 2018 Feb;144(4):431-442. doi: 10.1111/jnc.14275. Epub 2018 Jan 3.
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