Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMPIHLS)

• Drug Name: Diclofenac Drug Info
• Synonyms: Diclofenac (sodium matrix patch, pain)

Indication

Disease Entry	ICD 11	Status	REF
Chronic renal failure	GB61.Z	Approved	[1]
Dysmenorrhea	GA34.3	Approved	[1]
Knee osteoarthritis	FA01	Approved	[1]
Osteoarthritis	FA00-FA05	Approved	[2]
Pain	MG30-MG3Z	Approved	[1]

• Therapeutic Class: Neurology Agents
• Cross-matching ID:
  PubChem CID: 3033
  ChEBI ID: CHEBI:47381
  CAS Number: CAS 15307-86-5
  TTD Drug ID: DMPIHLS
  VARIDT Drug ID: DR00681
  INTEDE Drug ID: DR0488
  ACDINA Drug ID: D00192

Molecule-Related Drug Atlas

Drug(s) Targeting Prostaglandin G/H synthase (COX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[22]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[23]
Dexibuprofen	DMFYBD0	Ankylosing spondylitis	FA92.0	Approved	[24]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[25]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[26]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[27]
Aceclofenac	DMZDF0B	Inflammation	1A00-CA43.1	Approved	[28]
Lornoxicam	DMYZFXN	Migraine	8A80	Approved	[29]
Morniflumate	DM9UTDE	Otitis media	AA80-AB0Z	Approved	[30]
Nepafenac	DMYK490	Osteoarthritis	FA00-FA05	Approved	[31]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[34]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[37]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[43]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[42]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[44]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[45]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[46]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[47]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[46]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[48]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[49]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[50]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[51]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[56]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[50]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[12]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[131]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[132]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[133]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[134]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[135]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[136]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[57]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[58]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[55]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[63]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[64]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[65]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[147]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[147]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[147]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[148]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[149]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[150]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[151]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[152]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[153]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[154]

Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[66]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[63]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[70]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[71]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[72]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[73]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[74]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[137]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[138]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[139]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[140]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[145]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[146]

Drug(s) Metabolized By Cytochrome P450 2C18 (CYP2C18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[75]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[76]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[77]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[78]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[79]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[80]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[75]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[81]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[82]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[85]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[83]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[86]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[76]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[87]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[75]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[92]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[155]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[132]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[131]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[148]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[156]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[132]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[157]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[131]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[132]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[96]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[75]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[98]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[99]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[100]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[101]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[104]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[75]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[107]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[76]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[75]

Drug(s) Metabolized By Cholesterol 24-hydroxylase (CYP46A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[14]
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[14]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[108]
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[163]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]

Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[109]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[86]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[12]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[115]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[12]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A3 (UGT1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[12]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[117]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[118]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[115]
Losartan	DM72JXH	Diabetic kidney disease	GB61.Z	Approved	[12]
Naproxen	DMZ5RGV	Bursitis		Approved	[120]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[121]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[12]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[123]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[12]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[12]
Haloperidol	DM96SE0	Delirium		Approved	[12]
Naproxen	DMZ5RGV	Bursitis		Approved	[120]

Drug(s) Metabolized By Cytochrome P450 102A1 (cyp102)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[125]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[126]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[125]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[127]
Chlorzoxazone	DMCYVDT	Acute pain	MG31	Approved	[127]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[125]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[125]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[15]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[15]
GEA-6414	DM8J0MK	N. A.	N. A.	Phase 1/2	[15]

Drug(s) Metabolized By Cytochrome P450 105D7 (cyp105)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[16]
Mevastatin	DM1LGKP	N. A.	N. A.	Terminated	[16]
Q-27137207	DML5KMT	N. A.	N. A.	Investigative	[16] , [17]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[131]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[159]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[148]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[132]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[150]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[132]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[158]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[154]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[170]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[175]

Drug(s) Affected By Solute carrier family 22 member 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[176]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[177]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[178]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[179]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[184]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[181]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[187]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[181]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[188]
Ketoprofen	DMRKXPT	Bursitis		Approved	[181]

Drug(s) Affected By Organic anion transporter 7 (SLC22A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[190]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[191]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[181]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[182]

Drug(s) Affected By Solute carrier family 22 member 11 (SLC22A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[181]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[193]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[181]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[194]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[195]
Ketoprofen	DMRKXPT	Bursitis		Approved	[181]

Drug(s) Affected By Solute carrier family 22 member 7 (SLC22A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[190]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[197]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[197]
Bumetanide	DMRV7H0	Congestive heart failure	BD10	Approved	[197]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[197]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[197]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[197]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[198]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[207]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[209]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[210]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[213]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[217]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[217]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[220]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[217]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[217]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[217]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[222]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[223]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[226]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[229]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]

Drug(s) Affected By Protransforming growth factor alpha (TGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[236]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[240]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[241]
Fructose	DM43AN2	Vomiting	MD90	Approved	[154]
Ketoprofen	DMRKXPT	Bursitis		Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[243]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[244]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[154]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[249]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[250]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[251]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[253]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[254]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Selenium	DM25CGV	N. A.	N. A.	Approved	[257]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[175]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[265]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[266]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[267]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[281]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[282]
Methysergide	DM1EF73	Migraine	8A80	Approved	[283]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[285]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[286]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[289]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[290]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[229]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[294]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[297]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[301]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[302]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[305]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[307]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[308]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[311]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[313]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[314]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]

Drug(s) Affected By Adenosine kinase (ADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[322]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[326]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[328]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[329]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[330]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[331]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[332]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[335]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[336]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[349]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[350]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[347]

Drug(s) Affected By Antiviral innate immune response receptor RIG-I (RIGI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[346]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[359]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[209]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[361]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[263]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[266]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[263]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[364]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[365]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[370]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[368]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[372]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[376]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[377]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[379]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[384]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[385]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[386]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[201]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[389]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[390]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[353]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[395]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[397]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[400]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[401]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[402]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[21]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[404]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[407]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[408]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[409]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Lymphocyte antigen 6E (LY6E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[21]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[353]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Olfactomedin-like protein 2B (OLFML2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[21]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[410]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[411]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[413]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19B (RNF19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[414]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC6 (HERC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[415]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[379]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[346]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Bortezomib	DMNO38U	Leukemia		Approved	[417]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[419]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[182]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]

Drug(s) Affected By Latexin (LXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[422]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[424]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[425]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[426]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[427]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Bortezomib	DMNO38U	Leukemia		Approved	[428]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]

Drug(s) Affected By Large neutral amino acids transporter small subunit 2 (SLC7A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[21]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[21]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[280]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[434]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[435]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[435]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[436]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[434]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[435]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[283]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[434]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[437]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[434]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[439]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[440]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[442]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[444]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[445]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[446]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[447]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[449]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[450]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[451]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[451]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[452]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[453]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[454]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[450]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[455]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[456]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[457]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[458]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[459]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[460]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]

Drug(s) Affected By Glutathione S-transferase Mu 4 (GSTM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[463]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[456]

Drug(s) Affected By Glutathione S-transferase A3 (GSTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[272]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[464]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[465]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[443]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[466]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[467]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[154]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[468]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[469]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[471]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[154]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[158]

Drug(s) Affected By Thymidine kinase 2, mitochondrial (TK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[190]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[472]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[473]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[474]

Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[477]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[395]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[483]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[484]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[485]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[486]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[488]

Drug(s) Affected By Suppressor of cytokine signaling 7 (SOCS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[490]

Drug(s) Affected By Suppressor of cytokine signaling 6 (SOCS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[491]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[492]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[160]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[498]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[503]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[504]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[506]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[310]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[507]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[508]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[509]
Selenium	DM25CGV	N. A.	N. A.	Approved	[510]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[511]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[511]

Drug(s) Affected By Guanine nucleotide-binding protein subunit beta-5 (GNB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
N-(3-METHYLBUT-2-EN-1-YL)-9H-PURIN-6-AMINE	DM2D4KY	Discovery agent	N.A.	Investigative	[512]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC1 (POLR3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]

Drug(s) Affected By Ras-related protein M-Ras (MRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[516]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[518]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[519]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[521]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[522]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[523]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Histone acetyltransferase type B catalytic subunit (HAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[524]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[525]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[527]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[366]

Drug(s) Affected By Antizyme inhibitor 1 (AZIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[279]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[529]

Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[531]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[532]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]

Drug(s) Affected By Fanconi anemia group G protein (FANCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[533]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[534]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[534]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[534]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[534]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[534]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[534]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[534]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[534]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[535]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[536]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[537]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[538]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[539]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[540]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[541]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[543]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[544]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[545]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[547]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[548]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[549]

Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[552]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[553]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[553]

Drug(s) Affected By Adenylate cyclase type 6 (ADCY6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[554]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[555]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[556]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 7 (MAP3K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[557]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[559]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[560]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[561]
Bortezomib	DMNO38U	Leukemia		Approved	[562]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[563]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[565]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[365]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[566]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[567]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[568]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[565]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[569]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Integral membrane protein 2A (ITM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[571]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[572]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[573]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[206]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 14 (MED14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[487]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[206]

Drug(s) Affected By RNA helicase aquarius (AQR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[560]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[574]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]

Drug(s) Affected By Frizzled-6 (FZD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[422]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[462]

Drug(s) Affected By Adenylate cyclase type 9 (ADCY9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[575]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[575]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[473]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]

Drug(s) Affected By DNA polymerase zeta catalytic subunit (REV3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[484]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[409]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[456]

Drug(s) Affected By DnaJ homolog subfamily A member 2 (DNAJA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Indomethacin	DMSC4A7	Bursitis		Approved	[576]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[577]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[578]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[579]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[486]

Drug(s) Affected By Auxilin (DNAJC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[580]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Frizzled-7 (FZD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[415]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[581]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]

Drug(s) Affected By Rho-associated protein kinase 2 (ROCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[582]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Indomethacin	DMSC4A7	Bursitis		Approved	[576]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[583]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[271]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]

Drug(s) Affected By Nucleoside diphosphate phosphatase ENTPD5 (ENTPD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[293]

Drug(s) Affected By DNA polymerase theta (POLQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[395]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[585]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[586]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[588]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[587]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[589]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[590]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[587]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 6 (MED6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[591]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[593]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[595]

Drug(s) Affected By DnaJ homolog subfamily C member 8 (DNAJC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[596]

Drug(s) Affected By Serine/threonine-protein kinase D3 (PRKD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[599]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Epsin-2 (EPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[600]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]

Drug(s) Affected By Neuroendocrine secretory protein 55 (GNAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[601]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[491]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[603]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[605]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[606]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[607]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Formimidoyltransferase-cyclodeaminase (FTCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[608]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[609]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[610]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[302]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[611]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[166]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[612]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[613]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[614]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[615]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[614]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[616]
Haloperidol	DM96SE0	Delirium		Approved	[154]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[617]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[618]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[619]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[620]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[621]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[621]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[622]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[623]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[624]

Drug(s) Affected By GTPase NRas (NRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[625]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[626]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[628]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[629]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[625]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[626]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[630]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[631]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[632]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[633]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[627]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[630]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[366]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[366]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[635]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[361]
Selenium	DM25CGV	N. A.	N. A.	Approved	[257]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[636]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[637]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[638]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[639]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[640]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[641]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[642]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[643]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[644]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[645]

Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[646]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[646]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[646]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[646]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[647]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[648]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[649]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[289]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[650]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[651]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[652]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[654]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[655]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[651]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[656]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[366]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[366]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[366]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[366]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[366]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[657]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[658]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[659]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[660]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[661]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[662]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[663]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]

Drug(s) Affected By Argininosuccinate lyase (ASL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[665]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[666]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[667]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[668]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[669]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[670]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[671]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[672]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[673]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[674]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[675]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[675]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[595]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[675]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[675]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[676]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[677]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[678]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[679]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[680]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[681]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[682]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[683]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[684]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[589]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[685]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[686]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[687]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[687]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[688]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[689]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[690]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[691]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[692]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[693]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[214]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[694]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[695]
Fructose	DM43AN2	Vomiting	MD90	Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[696]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[267]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[697]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[698]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC4 (POLR3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[557]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Fructose	DM43AN2	Vomiting	MD90	Approved	[700]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[701]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[702]

Drug(s) Affected By Insulin receptor (INSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[703]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[704]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[705]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[706]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[402]
Methamphetamine	DMPM4SK	Anxiety		Approved	[706]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[707]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[708]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[709]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[230]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[710]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[501]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[711]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[675]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[712]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[595]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[713]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[714]
Selenium	DM25CGV	N. A.	N. A.	Approved	[715]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[716]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[717]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[718]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[719]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[720]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[721]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[722]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[723]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[724]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[725]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[635]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[727]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[728]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[729]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[730]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[731]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[731]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[732]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[733]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[734]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[595]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[735]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[736]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[737]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[209]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[267]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[738]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[739]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[739]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[739]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[740]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[741]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[742]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[743]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[744]
Selenium	DM25CGV	N. A.	N. A.	Approved	[745]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[746]

Drug(s) Affected By Serine/threonine-protein kinase A-Raf (ARAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[747]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[748]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[749]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[533]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[750]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[751]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[752]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[753]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[754]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[755]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[756]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[757]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[243]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]

Drug(s) Affected By Nuclear receptor subfamily 2 group F member 6 (NR2F6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[233]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[758]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[759]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[760]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[761]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[453]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[762]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[763]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[764]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[765]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[503]

Drug(s) Affected By Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[766]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[767]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[768]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[768]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[769]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[770]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[771]

Drug(s) Affected By Bone morphogenetic protein 4 (BMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[772]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[773]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[774]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[775]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[776]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[653]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[777]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[701]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[778]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[779]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[780]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[781]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[782]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[630]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[630]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[360]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[783]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[784]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[375]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[785]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[786]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By L-selectin (SELL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[787]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[788]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[787]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[789]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[787]
Phenylbutazone	DMAYL0T	Chronic pain	MG30	Approved	[787]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[790]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[790]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By POU domain, class 2, transcription factor 1 (POU2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[791]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[792]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[793]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[791]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[793]

Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[749]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[794]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[795]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[796]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[797]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[798]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[799]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Bortezomib	DMNO38U	Leukemia		Approved	[417]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[20]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[20]

Drug(s) Affected By Transcription factor E2-alpha (TCF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[800]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[801]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[456]

Drug(s) Affected By Replication protein A 32 kDa subunit (RPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[802]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[506]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[803]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[398]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[804]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[805]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[802]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[806]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[433]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[807]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[808]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[809]

Drug(s) Affected By Carbonyl reductase 1 (CBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[810]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[471]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[811]

Drug(s) Affected By Tyrosine-protein kinase Fer (FER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[812]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[456]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[453]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[813]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[814]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]

Drug(s) Affected By Rho-related GTP-binding protein RhoQ (RHOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[404]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[815]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[816]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[166]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[817]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[818]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[819]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[820]

Drug(s) Affected By Integrin alpha-2 (ITGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[677]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[821]

Drug(s) Affected By CTP synthase 1 (CTPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[473]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[822]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[822]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX5 (DDX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[823]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Haloperidol	DM96SE0	Delirium		Approved	[602]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Selenium	DM25CGV	N. A.	N. A.	Approved	[824]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[825]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[826]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[827]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[828]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[665]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[829]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[830]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[21]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[831]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[832]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[508]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[589]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[590]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[833]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[797]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[602]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[834]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[835]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[836]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[837]

Drug(s) Affected By Casein kinase II subunit alpha' (CSNK2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[838]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[207]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[839]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[619]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[840]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[406]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[540]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Hepatocyte nuclear factor 1-alpha (HNF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[841]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[842]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[801]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[843]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Ras GTPase-activating protein 1 (RASA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[844]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[648]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[404]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[845]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[846]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[847]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[848]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[848]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[849]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[850]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[848]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[851]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[593]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[852]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[852]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[772]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[366]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[366]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[366]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[366]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[853]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[366]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]

Drug(s) Affected By Trifunctional purine biosynthetic protein adenosine-3 (GART)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[601]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[395]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[555]

Drug(s) Affected By 5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[533]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
CATECHOL	DML0YEK	Discovery agent	N.A.	Investigative	[854]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[373]
Protoporphyrin IX	DMWYE7A	Discovery agent	N.A.	Investigative	[855]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL (CBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[856]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[271]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[858]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]

Drug(s) Affected By Glycine dehydrogenase (GLDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[531]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[415]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[859]

Drug(s) Affected By Thymidylate kinase (DTYMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[154]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[860]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[861]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[154]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[154]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[154]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[862]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[815]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[862]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[862]

Drug(s) Affected By COUP transcription factor 2 (NR2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[800]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[863]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[769]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[710]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[864]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[684]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[865]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[866]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[867]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[863]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[868]
Selenium	DM25CGV	N. A.	N. A.	Approved	[228]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[869]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[544]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[870]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[871]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[872]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[873]
Fructose	DM43AN2	Vomiting	MD90	Approved	[700]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[635]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]

Drug(s) Affected By Amine oxidase B (MAOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[874]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[875]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[876]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[877]
Linezolid	DMGFPU2	Bacteremia	1A73	Approved	[878]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[879]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[880]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[881]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[243]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[882]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[883]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[884]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[885]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[886]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[887]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[888]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[889]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[397]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[890]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[796]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Replication protein A 70 kDa DNA-binding subunit (RPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[891]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[892]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[818]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[894]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[895]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[880]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[896]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[897]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[898]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[879]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[243]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[882]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[899]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[900]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[901]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[902]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[903]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[904]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[905]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[906]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[907]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[672]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[908]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[909]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[910]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[229]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[252]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[911]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[912]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[913]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[914]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[298]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[915]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[916]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]

Drug(s) Affected By Cleavage stimulation factor subunit 2 (CSTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[602]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]

Drug(s) Affected By Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[917]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[491]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[918]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[919]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Serine hydroxymethyltransferase, cytosolic (SHMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[920]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[696]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[921]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[922]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[923]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[924]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[925]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[926]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[927]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Indomethacin	DMSC4A7	Bursitis		Approved	[619]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[928]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[929]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[930]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[931]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[203]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[932]

Drug(s) Affected By Cystathionine beta-synthase (CBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[933]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[934]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[182]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[935]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[936]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[937]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[938]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[939]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[940]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[508]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[762]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[941]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[593]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]

Drug(s) Affected By Choline kinase alpha (CHKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Activin receptor type-1B (ACVR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[942]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[491]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[858]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[943]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[944]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[945]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[946]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[947]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[948]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[873]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[949]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[950]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[154]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[951]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[952]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[953]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[954]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[955]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[780]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[956]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[611]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]

Drug(s) Affected By Glycine--tRNA ligase (GARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[295]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[166]

Drug(s) Affected By Reduced folate transporter (SLC19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[957]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[958]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[958]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[959]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[959]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[959]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[595]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[166]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[960]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Protein kinase C iota type (PRKCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[961]
Indomethacin	DMSC4A7	Bursitis		Approved	[576]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[456]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[962]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[963]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[964]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[965]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[963]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[966]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[967]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[968]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[969]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[970]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[971]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[669]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[972]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[973]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[974]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[975]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[976]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[977]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[757]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[978]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[979]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[980]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[607]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[981]

Drug(s) Affected By Tyrosine-protein kinase ABL2 (ABL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[982]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By Transcription factor GATA-4 (GATA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[805]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[983]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[984]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[800]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[985]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[986]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[986]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[987]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[696]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[697]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[685]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[988]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[697]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[989]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[708]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[290]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[990]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[991]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[652]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[992]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[864]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[993]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[994]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[799]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Eukaryotic translation initiation factor 1A, X-chromosomal (EIF1AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Indomethacin	DMSC4A7	Bursitis		Approved	[576]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[362]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[284]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[995]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[996]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[997]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[584]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[998]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[915]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[999]

Drug(s) Affected By Serine--tRNA ligase, cytoplasmic (SARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Haloperidol	DM96SE0	Delirium		Approved	[602]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[602]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[760]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[709]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1000]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1001]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1002]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1003]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[590]

Drug(s) Affected By Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[600]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[942]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Cyclin-dependent kinase 7 (CDK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1004]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1005]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1006]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1007]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1008]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[1009]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[1010]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1011]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1012]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[1013]

Drug(s) Affected By Cyclin-H (CCNH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1014]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1015]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1004]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[532]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[1016]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[900]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[919]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[799]

Drug(s) Affected By DNA polymerase subunit gamma-1 (POLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[1017]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[1018]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1019]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1020]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1021]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[981]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[1022]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[757]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1023]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[928]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1024]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1025]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1026]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[297]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1027]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1028]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1015]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1029]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1030]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Tumor protein D52 (TPD52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[848]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[848]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[848]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[600]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit B (EIF3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1031]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1032]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1032]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Selenium	DM25CGV	N. A.	N. A.	Approved	[510]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1033]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1034]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[798]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By C-terminal-binding protein 2 (CTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[1035]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[800]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[648]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[672]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1036]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1037]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1038]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1039]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]

Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1040]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1041]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1042]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[532]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]

Drug(s) Affected By DNA-directed RNA polymerases I, II, and III subunit RPABC2 (POLR2F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1043]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1043]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[596]

Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1044]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1045]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1046]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]

Drug(s) Affected By Ras-related protein R-Ras2 (RRAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[845]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[1047]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[702]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[819]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1048]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1049]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[813]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1050]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1050]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[602]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[1051]

Drug(s) Affected By Actin, alpha skeletal muscle (ACTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]

Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1052]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[269]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[1053]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1054]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[611]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Phosphatidylinositol-glycan-specific phospholipase D (GPLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[601]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1055]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1056]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[413]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1057]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[729]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1023]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[761]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1058]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1059]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1060]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1061]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[674]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[709]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[710]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[901]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1002]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1062]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1063]

Drug(s) Affected By Fanconi anemia group C protein (FANCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1064]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[321]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1065]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[1066]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1066]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1067]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1068]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[1066]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[1066]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1066]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1066]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1069]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[863]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1070]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[710]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]

Drug(s) Affected By Myocyte-specific enhancer factor 2A (MEF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1071]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[275]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[1072]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Cytochrome P450 4A11 (CYP4A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[1073]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[1074]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1074]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1074]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[1074]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1074]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[288]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1075]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[840]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1027]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1076]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1077]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1078]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1079]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1080]

Drug(s) Affected By Activin receptor type-1 (ACVR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1081]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1082]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[175]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1083]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[883]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1084]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1085]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[270]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1086]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1087]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[1088]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[610]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1089]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1090]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[983]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[803]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1091]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1092]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1093]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[752]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[977]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[756]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[381]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1023]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[770]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[672]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1094]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1095]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1096]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[1097]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Son of sevenless homolog 2 (SOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[404]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1063]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[986]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[909]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1099]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1078]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Cleavage stimulation factor subunit 3 (CSTF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1100]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[366]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[211]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[366]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[366]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[733]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[366]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 5 (MAP2K5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[1101]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1102]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]

Drug(s) Affected By Growth factor receptor-bound protein 10 (GRB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[491]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[456]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[1103]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1103]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1104]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[813]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1048]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[582]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[1105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1106]

Drug(s) Affected By Frizzled-5 (FZD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By GRB2-associated-binding protein 1 (GAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[409]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[942]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1110]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[229]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1113]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[894]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]

Drug(s) Affected By Cullin-3 (CUL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[271]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]

Drug(s) Affected By Activin receptor type-2B (ACVR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[943]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[602]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[813]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]

Drug(s) Affected By Rho guanine nucleotide exchange factor 7 (ARHGEF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[491]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]

Drug(s) Affected By ARF GTPase-activating protein GIT2 (GIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1117]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[559]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[767]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]

Drug(s) Affected By Transcription factor E2F2 (E2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]

Drug(s) Affected By Translation initiation factor eIF2B subunit alpha (EIF2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[843]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[1118]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[605]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[1119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]

Drug(s) Affected By Guanine nucleotide-binding protein subunit alpha-13 (GNA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[648]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[154]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1120]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[1121]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1122]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[823]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1124]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[1126]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1128]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1131]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1025]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1133]

Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[840]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[1134]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[675]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[1135]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[1136]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[1136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1136]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[409]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1117]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 5 (PSG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[1137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By Transcription factor E2F5 (E2F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[554]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Nuclear receptor subfamily 6 group A member 1 (NR6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[558]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[759]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-1 (RPS6KA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1139]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 7 (PPP1R7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1140]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[438]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[284]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[263]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[266]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[263]

Drug(s) Affected By ETS-related transcription factor Elf-2 (ELF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[600]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1142]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1144]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[210]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[521]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1145]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[900]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[989]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1149]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[602]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1152]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[1154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1015]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1155]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1156]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[619]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[1160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1092]

Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 6 (CPSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Indomethacin	DMSC4A7	Bursitis		Approved	[576]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1162]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1163]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1163]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1165]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[771]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1166]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1167]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[848]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1168]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[848]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[781]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[848]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]

Drug(s) Affected By UMP-CMP kinase 2, mitochondrial (CMPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By DnaJ homolog subfamily C member 21 (DNAJC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[163]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[1169]

Drug(s) Affected By Transcription initiation factor TFIID subunit 3 (TAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[519]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[1170]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D (NAPEPLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By General transcription factor IIH subunit 5 (GTF2H5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[1016]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[1171]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[499]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13-like (MED13L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[366]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[366]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[366]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[366]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[366]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[366]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[366]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Glycerate kinase (GLYCTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[750]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[766]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1172]

Drug(s) Affected By DnaJ homolog subfamily C member 10 (DNAJC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[484]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[272]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[600]

Drug(s) Affected By Mitochondrial Rho GTPase 2 (RHOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[456]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]

Drug(s) Affected By Fanconi anemia group M protein (FANCM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[395]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[766]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]

Drug(s) Affected By Angiogenic factor with G patch and FHA domains 1 (AGGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1173]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Fanconi anemia group B protein (FANCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]

Drug(s) Affected By Choline dehydrogenase, mitochondrial (CHDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[206]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[1174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[750]

Drug(s) Affected By Tudor domain-containing protein 7 (TDRD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]

Drug(s) Affected By DnaJ homolog subfamily B member 14 (DNAJB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[767]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 4 (CREB3L4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[600]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[369]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[1175]

Drug(s) Affected By Fibroblast growth factor receptor substrate 2 (FRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
AZD4547	DM3827C	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[906]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By DnaJ homolog subfamily C member 9 (DNAJC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[272]

Drug(s) Affected By Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[166]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[166]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]

Drug(s) Affected By Proteasome inhibitor PI31 subunit (PSMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[392]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Mestranol	DMG3F94	Contraception	QA21	Approved	[1176]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1176]

Drug(s) Affected By Hamartin (TSC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]

Drug(s) Affected By General transcription factor IIH subunit 4 (GTF2H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1055]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1178]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1179]

Drug(s) Affected By Caspase-10 (CASP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[604]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1180]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1031]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[484]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1182]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[354]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[1183]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]

Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[646]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[646]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[646]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[298]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[646]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[646]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[646]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 14B (PPP1R14B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[602]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1184]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[1186]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[1187]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[1047]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1188]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By DnaJ homolog subfamily A member 3, mitochondrial (DNAJA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[750]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]

Drug(s) Affected By Thialysine N-epsilon-acetyltransferase (SAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 30 (MED30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[600]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Selenium	DM25CGV	N. A.	N. A.	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1191]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1192]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1194]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1195]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[675]

Drug(s) Affected By Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By Formin-binding protein 1 (FNBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]

Drug(s) Affected By Paired amphipathic helix protein Sin3a (SIN3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1030]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1198]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[496]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[342]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit C (EIF3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[353]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]

Drug(s) Affected By DnaJ homolog subfamily C member 7 (DNAJC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[531]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[293]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[1200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[1201]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[480]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[494]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1202]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[1204]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[306]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[494]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[273]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 1 (EIF2AK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[415]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[1170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 10 (MED10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[528]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[579]

Drug(s) Affected By Fanconi anemia group J protein (BRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[508]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1208]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[1209]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[315]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[1210]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[534]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[534]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[534]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[534]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[534]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[534]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[534]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[534]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[534]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1211]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[849]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[166]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]

Drug(s) Affected By Group XIIA secretory phospholipase A2 (PLA2G12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[486]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[206]

Drug(s) Affected By Epsin-3 (EPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1212]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]

Drug(s) Affected By DnaJ homolog subfamily C member 5 (DNAJC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1213]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By dCTP pyrophosphatase 1 (DCTPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]

Drug(s) Affected By DnaJ homolog subfamily C member 18 (DNAJC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[579]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[499]

Drug(s) Affected By Protein argonaute-3 (AGO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]

Drug(s) Affected By MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]

Drug(s) Affected By Transcription initiation factor TFIID subunit 9B (TAF9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[417]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1173]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[293]

Drug(s) Affected By Calpain-10 (CAPN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[1215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1216]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]

Drug(s) Affected By Protein argonaute-4 (AGO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]

Drug(s) Affected By Frizzled-3 (FZD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[484]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[1217]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]

Drug(s) Affected By Fanconi anemia group F protein (FANCF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[490]
Manganese	DMKT129	N. A.	N. A.	Investigative	[1219]

Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[800]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[415]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Bortezomib	DMNO38U	Leukemia		Approved	[428]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 7 (ENTPD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[166]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]

Drug(s) Affected By DNA polymerase epsilon subunit 4 (POLE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1221]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[1222]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[462]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Rho guanine nucleotide exchange factor 3 (ARHGEF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1223]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[1224]

Drug(s) Affected By CTP synthase 2 (CTPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[470]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By DNA polymerase epsilon subunit 3 (POLE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[425]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 17 (MED17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[592]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1226]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[490]

Drug(s) Affected By DnaJ homolog subfamily C member 11 (DNAJC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[316]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[514]

Drug(s) Affected By E3 ubiquitin-protein ligase FANCL (FANCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[278]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[415]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[526]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Very long chain fatty acid elongase 2 (ELOVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[260]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[919]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[493]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[486]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[585]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[224]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[587]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1227]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[587]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[589]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[590]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[833]

Drug(s) Affected By eIF-2-alpha kinase GCN2 (EIF2AK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[648]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[551]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1059]
Fructose	DM43AN2	Vomiting	MD90	Approved	[1228]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1071]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[724]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[1230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[1230]

Drug(s) Affected By Set1/Ash2 histone methyltransferase complex subunit ASH2 (ASH2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[383]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[597]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1056]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[166]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[280]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[999]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[594]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13 (MED13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[648]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[164]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[699]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[919]

Drug(s) Affected By Protein TASOR (TASOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[403]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]

Drug(s) Affected By Apoptotic chromatin condensation inducer in the nucleus (ACIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[293]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[378]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1042]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Protein argonaute-2 (AGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]

Drug(s) Affected By Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Bortezomib	DMNO38U	Leukemia		Approved	[417]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[486]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1233]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[422]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[264]

Drug(s) Affected By Rho GTPase-activating protein 26 (ARHGAP26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[542]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[857]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By GRB2-associated-binding protein 2 (GAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[429]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[478]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[1234]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[486]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[499]

Drug(s) Affected By DNA polymerase eta (POLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[369]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[1235]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[1235]

Drug(s) Affected By Choline/ethanolamine kinase (CHKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[935]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1236]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[416]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[822]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[462]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[1238]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[489]

Drug(s) Affected By Endophilin-B1 (SH3GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[399]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[356]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[272]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 31 (MED31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1098]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[461]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[412]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[490]

Drug(s) Affected By DnaJ homolog subfamily C member 15 (DNAJC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[161]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[424]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[464]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[18]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1239]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[208]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[344]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[531]

Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[319]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[476]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1242]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[1242]

Drug(s) Affected By Nuclear receptor coactivator 3 (NCOA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1243]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[634]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[499]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[239]
Bortezomib	DMNO38U	Leukemia		Approved	[417]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[691]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1244]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[900]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1247]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[1248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1249]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1250]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1211]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1251]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[784]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[1252]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1245]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[1253]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1254]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[426]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1256]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Prostaglandin G/H synthase (COX)	TTK0943	PGH1_HUMAN; PGH2_HUMAN	Modulator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 2C9 (CYP2C9) Main DME	DE5IED8	CP2C9_HUMAN	Substrate	[7]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[8]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[8]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[9]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[10]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[11]
UDP-glucuronosyltransferase 2B7 (UGT2B7)	DEB3CV1	UD2B7_HUMAN	Substrate	[12]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Substrate	[13]
Cytochrome P450 2C18 (CYP2C18)	DEZMWRE	CP2CI_HUMAN	Substrate	[8]
UDP-glucuronosyltransferase 1A3 (UGT1A3)	DEF2WXN	UD13_HUMAN	Substrate	[13]
Cholesterol 24-hydroxylase (CYP46A1)	DEKP5HX	CP46A_HUMAN	Substrate	[14]
Cytochrome P450 102A1 (cyp102)	DE4OGUF	CPXB_BACMB	Substrate	[15]
Cytochrome P450 105D7 (cyp105)	DECV2ME	CYP28_STRAW	Substrate	[16] , [17]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1)	OTSBQR6D	PLCG1_HUMAN	Gene/Protein Processing	[18]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[18]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[19]
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[18]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[20]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[21]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Gene/Protein Processing	[18]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)	OTJXOUCL	HEM0_HUMAN	Gene/Protein Processing	[18]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Gene/Protein Processing	[18]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Gene/Protein Processing	[18]

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