Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMFELMQ)

• Drug Name: AMEP Drug Info
• Synonyms: (Aminomethyl)phosphonic acid; 1066-51-9; AMINOMETHYLPHOSPHONIC ACID; Aminomethanephosphonic acid; AMeP; 1-Aminomethylphosphonic acid; 1-Aminomethylphosphonate; Amino methane phosphoric acid; Caswell No. 037C; Phosphaglycine; (1-Aminomethyl)phosphonic acid; Phosphonic acid, aminomethyl-; UNII-90825O5C1U; Phosphonic acid, (aminomethyl)-; Aminomethylphosphonic acid (AMPA); NSC 30076; EPA Pesticide Chemical Code 207800; CHEBI:28812; MGRVRXRGTBOSHW-UHFFFAOYSA-N; (Aminomethyl)phosphonic acid, 99%; MFCD00008105; GEO-00169; 90825O5C1U

Indication

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Phase 1	[1]

• Cross-matching ID:
  PubChem CID: 14017
  ChEBI ID: CHEBI:28812
  CAS Number: CAS 1066-51-9
  TTD Drug ID: DMFELMQ

Molecule-Related Drug Atlas

Drug(s) Targeting Integrin alpha-V/beta-3 (ITGAV/B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cilengitide	DMEAOZ0	Rheumatoid arthritis	FA20	Phase 3	[6]
ATN-161	DM4T9RS	Renal cell carcinoma	2C90	Phase 2	[7]
Intetumumab	DMBXEG9	Prostate cancer	2C82.0	Phase 2	[8]
VLTS-589	DM4O17U	Peripheral vascular disease	BD4Z	Phase 2	[9]
Fluciclatide F-18	DME01HT	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
SF0166	DM4NK3J	Diabetic macular edema	9B71.02	Phase 1/2	[11]
Vitaxin	DMHCLVQ	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[12]
SB-267268	DMIBFAV	Osteoporosis	FB83.0	Discontinued in Phase 1	[13]
SB-273005	DMV7M1H	Osteoporosis	FB83.0	Discontinued in Phase 1	[14]
PS-388023	DM8P05S	Ocular disease	1F00.1Z	Terminated	[15]

Drug(s) Targeting Integrin alpha-5/beta-1 (ITGA5/B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ATN-161	DM4T9RS	Renal cell carcinoma	2C90	Phase 2	[7]
Volociximab	DMNQG24	Non-small-cell lung cancer	2C25.Y	Phase 2	[16]
F-200	DMVWZN1	Ocular disease	1F00.1Z	Terminated	[17]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[22]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[23]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[24]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[26]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[28]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[33]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[33]

Drug(s) Affected By Histone deacetylase 3 (HDAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[38]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[44]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[47]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[48]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]

Drug(s) Affected By Cathepsin L2 (CTSV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[57]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]

Drug(s) Affected By Nucleolar protein 3 (NOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Suppressor of cytokine signaling 5 (SOCS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[69]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Indomethacin	DMSC4A7	Bursitis		Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[72]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[77]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[79]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[86]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[89]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[94]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[95]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Fructose	DM43AN2	Vomiting	MD90	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[104]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[105]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[108]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[109]
Fructose	DM43AN2	Vomiting	MD90	Approved	[90]
Ketoprofen	DMRKXPT	Bursitis		Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[111]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[112]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[113]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[118]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[120]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[121]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[125]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[126]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[127]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[130]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[134]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[135]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[137]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[153]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[154]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[157]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[158]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[158]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[163]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[81]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[169]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[172]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[90]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[173]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[174]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[111]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[175]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[177]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[178]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[184]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[57]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[185]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[187]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[188]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[194]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[203]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[204]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[205]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[206]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[209]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[212]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[213]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[216]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[221]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[224]
Fructose	DM43AN2	Vomiting	MD90	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[226]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[231]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[234]

Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Bortezomib	DMNO38U	Leukemia		Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[239]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[240]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[241]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[242]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[244]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[242]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[245]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[194]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[250]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[251]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[252]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[254]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[255]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[212]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[258]
Haloperidol	DM96SE0	Delirium		Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[259]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[260]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[262]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[203]
Bortezomib	DMNO38U	Leukemia		Approved	[263]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[77]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[265]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[266]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[167]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[267]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[268]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[28]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[271]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[125]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[272]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[274]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[275]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[276]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[277]

Drug(s) Affected By Cathepsin O (CTSO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[278]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[280]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[281]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[282]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[285]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[288]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Fructose	DM43AN2	Vomiting	MD90	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[291]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[292]

Drug(s) Affected By Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[295]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[296]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[297]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[300]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[301]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[302]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[303]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[304]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[174]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[157]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[308]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[309]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[310]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[169]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[277]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[173]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[306]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[311]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[111]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[313]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[223]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[140]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[315]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[316]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[83]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[317]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[319]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[91]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[320]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[322]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[323]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[326]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[297]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[327]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[329]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[331]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[332]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[83]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[203]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[336]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[337]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[338]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[243]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[131]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3-like protein 2 (CREB3L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[55]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[203]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[340]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[341]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[342]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[343]

Drug(s) Affected By C-myc promoter-binding protein (DENND4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Bortezomib	DMNO38U	Leukemia		Approved	[69]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[344]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[345]

Drug(s) Affected By Macoilin (MACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[72]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[342]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[346]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[343]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[347]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[349]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[119]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[351]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[352]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[353]

Drug(s) Affected By Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[342]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[3]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[354]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[83]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[79]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]

Drug(s) Affected By HSPB1-associated protein 1 (HSPBAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[39]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[356]

Drug(s) Affected By Anaphase-promoting complex subunit 13 (ANAPC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[357]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[3]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[358]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[359]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[337]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[360]

Drug(s) Affected By Synaptonemal complex protein 2 (SYCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[362]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[342]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[4]

Drug(s) Affected By Kv channel-interacting protein 1 (KCNIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[363]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[364]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[342]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[4]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[366]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[367]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[368]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[27]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[262]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[369]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[297]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[370]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Integrin alpha-5/beta-1 (ITGA5/B1)	TTH4QIS	ITA5_HUMAN-ITB1_HUMAN	Modulator	[2]
Integrin alpha-V/beta-3 (ITGAV/B3)	TT69TQN	ITAV_HUMAN-ITB3_HUMAN	Modulator	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2)	OTGVC9MY	PLCG2_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein theta	OTWG7F3H	1433T_HUMAN	Gene/Protein Processing	[3]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Gene/Protein Processing	[4]
Anaphase-promoting complex subunit 13 (ANAPC13)	OTQWXHEJ	APC13_HUMAN	Gene/Protein Processing	[3]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[4]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Gene/Protein Processing	[4]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[4]
Bcl-2-related protein A1 (BCL2A1)	OTWRYSNA	B2LA1_HUMAN	Gene/Protein Processing	[4]

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