Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMZYX6)

• Drug Name: OXYBENZONE Drug Info
• Synonyms: oxybenzone; 131-57-7; 2-HYDROXY-4-METHOXYBENZOPHENONE; Benzophenone-3; Oxybenzon; 4-Methoxy-2-hydroxybenzophenone; 2-Benzoyl-5-methoxyphenol; (2-hydroxy-4-methoxyphenyl)(phenyl)methanone; Oxybenzonum; Oxibenzona; Anuvex; Methanone, (2-hydroxy-4-methoxyphenyl)phenyl-; Chimassorb 90; Uvinul 9; Advastab 45; Sunscreen UV-15; Syntase 62; Uvistat 24; Cyasorb UV 9; Usaf cy-9; Spectra-sorb UV 9; Escalol 567; Ongrostab HMB; Oxybenzonum [INN-Latin]; Uvinul M40; Oxibenzonum; Oxibenzona [INN-Spanish]; HMBP; Cyasorb UV 9 Light Absorber

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4632
  ChEBI ID: CHEBI:34283
  CAS Number: CAS 131-57-7
  TTD Drug ID: DMMZYX6

Molecule-Related Drug Atlas

Drug(s) Targeting Hormone sensitive lipase (LIPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BENZYL BENZOATE	DMDPYI5	Infestations of lice and scabies	1G00.Z	Approved	[5]
PMID15026062C41	DMJGFLD	Pancreatitis	DC31-DC34	Clinical trial	[6]
ETHIOFENCARB	DMQTEDP	Discovery agent	N.A.	Investigative	[1]
NCI-58425	DM9C7GP	Discovery agent	N.A.	Investigative	[1]
2-(3-methoxybenzylthio)-2-phenylacetic acid	DM21MAU	Discovery agent	N.A.	Investigative	[1]
BIFENOX	DM4MUXT	Discovery agent	N.A.	Investigative	[1]
NCI-159878	DMTCBLS	Discovery agent	N.A.	Investigative	[1]
PMI-008	DMHX704	Obesity	5B81	Investigative	[7]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[9]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[10]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[14]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[32]

Drug(s) Affected By Rho-associated protein kinase 2 (ROCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[34]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]

Drug(s) Affected By E3 SUMO-protein ligase PIAS1 (PIAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[46]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[47]

Drug(s) Affected By Cell cycle checkpoint protein RAD17 (RAD17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[50]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[52]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[53]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[54]

Drug(s) Affected By Nuclear factor of activated T-cells 5 (NFAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[61]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[11]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[69]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[57]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[74]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[76]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[78]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[82]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[85]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[93]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[97]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[98]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[46]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[103]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[104]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[105]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[106]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[107]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[116]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[117]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[119]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[98]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[120]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[127]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[130]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[134]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[136]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[137]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[61]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[140]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[141]

Drug(s) Affected By Dihydrolipoyl dehydrogenase, mitochondrial (DLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[144]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[145]

Drug(s) Affected By Ras-related protein Rap-2a (RAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[148]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[8]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[10]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[149]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[10]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[57]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[155]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[155]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[159]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[160]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[156]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[167]
Bortezomib	DMNO38U	Leukemia		Approved	[168]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[80]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[8]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[174]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[176]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[177]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[181]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[165]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[189]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[40]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[40]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[192]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[200]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[203]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[204]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[167]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[207]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[210]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Retinoblastoma-like protein 1 (RBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 4 (PTPN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[213]
Crocin	DM5F24X	N. A.	N. A.	Phase 3	[214]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[12]

Drug(s) Affected By Replication factor C subunit 1 (RFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[216]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[11]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[11]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[11]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[218]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[219]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[220]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[222]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[223]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[136]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[228]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[229]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[229]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[233]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[236]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[237]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]

Drug(s) Affected By Protein kinase C iota type (PRKCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[243]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Indomethacin	DMSC4A7	Bursitis		Approved	[244]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[38]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]

Drug(s) Affected By Leukemia inhibitory factor receptor (LIFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[247]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[248]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[250]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[251]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[253]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[254]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[255]

Drug(s) Affected By Double-strand break repair protein MRE11 (MRE11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[256]

Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[11]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Drug(s) Affected By Voltage-dependent calcium channel subunit alpha-2/delta-1 (CACNA2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[48]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[213]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[257]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[54]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[262]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]

Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[269]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[270]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[271]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[272]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[272]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[83]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[277]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[278]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[279]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[280]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[281]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[283]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[236]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By TP53-binding protein 1 (TP53BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[287]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[295]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[34]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[300]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[303]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[305]

Drug(s) Affected By Helicase-like transcription factor (HLTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[40]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[306]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[309]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[208]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[312]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[313]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[314]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By Nuclear receptor coactivator 2 (NCOA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[315]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[213]

Drug(s) Affected By Mitogen-activated protein kinase 6 (MAPK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[316]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[317]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[318]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[54]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[319]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[320]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[321]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[321]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[322]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[323]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[324]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[294]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[82]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[198]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[10]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[92]
Mestranol	DMG3F94	Contraception	QA21	Approved	[10]

Drug(s) Affected By Rapamycin-insensitive companion of mTOR (RICTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[325]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[326]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[327]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[327]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[16]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[69]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[152]

Drug(s) Affected By Probable D-lactate dehydrogenase, mitochondrial (LDHD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[328]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]

Drug(s) Affected By RB1-inducible coiled-coil protein 1 (RB1CC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[329]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[316]
Bortezomib	DMNO38U	Leukemia		Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[331]

Drug(s) Affected By Cohesin subunit SA-1 (STAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[328]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[332]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[146]

Drug(s) Affected By DNA topoisomerase 2-binding protein 1 (TOPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[333]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[334]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[335]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[336]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]

Drug(s) Affected By Autophagy-related protein 2 homolog B (ATG2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[329]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[191]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[337]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[338]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[339]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[8]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[213]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Mestranol	DMG3F94	Contraception	QA21	Approved	[8]

Drug(s) Affected By Transcription initiation factor TFIID subunit 9B (TAF9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[52]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[213]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[38]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[341]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[342]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[204]

Drug(s) Affected By Serine/threonine-protein kinase TBK1 (TBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[343]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[346]
Flavonoid derivative 1	DMCQP0B	N. A.	N. A.	Patented	[345]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 13 (MED13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[347]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[143]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[213]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[348]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[154]

Drug(s) Affected By Histone deacetylase 9 (HDAC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[349]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[350]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[349]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[351]
Indomethacin	DMSC4A7	Bursitis		Approved	[352]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[289]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[12]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[58]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[24]
Bortezomib	DMNO38U	Leukemia		Approved	[168]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[353]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[53]

Drug(s) Affected By Cyclin-D-binding Myb-like transcription factor 1 (DMTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[354]
Selenium	DM25CGV	N. A.	N. A.	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[355]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[338]

Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[204]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[39]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[217]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[213]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[356]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[245]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[358]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[357]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[359]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[360]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[358]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[156]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hormone sensitive lipase (LIPE)	TTLUQ8E	LIPS_HUMAN	Inhibitor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[2]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Gene/Protein Processing	[3]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[4]
Autophagy-related protein 2 homolog B (ATG2B)	OT7FGFJ1	ATG2B_HUMAN	Gene/Protein Processing	[3]
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN	OT81JS6K	WRN_HUMAN	Gene/Protein Processing	[3]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Gene/Protein Processing	[3]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB)	OT6RMDCE	KAPCB_HUMAN	Gene/Protein Processing	[3]
Cell cycle checkpoint protein RAD17 (RAD17)	OT1I93DT	RAD17_HUMAN	Gene/Protein Processing	[3]
Cohesin subunit SA-1 (STAG1)	OT564IX4	STAG1_HUMAN	Gene/Protein Processing	[3]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2)	OTNIZPEA	ATF2_HUMAN	Gene/Protein Processing	[3]

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