Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJV2EK)

• Drug Name: Dasatinib Drug Info
• Synonyms: Sprycel (TN); BMS 354825; BMS-354825; BMS-354825, Sprycel, BMS354825, Dasatinib; BMS354825; Dasatinib (USAN); Dasatinib [USAN]; Dasatinib anhydrous; Dasatinib, BMS 354825; Dasatinibum; Sprycel; Spyrcel

Indication

Disease Entry	ICD 11	Status	REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1]
Brain disease	8C70-8E61	Approved	[1]
Central nervous system disease	8A04-8D87	Approved	[1]
Chronic myelogenous leukaemia	2A20.0	Approved	[2]
Chronic myeloid leukaemia	2A20	Approved	[3]
Glioblastoma	2A00	Approved	[1]
Leukemia		Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Non-small-cell lung cancer	2C25.Y	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[1]
Multiple myeloma	2A83	Phase 2	[2]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[4]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[4]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 3062316
  ChEBI ID: CHEBI:49375
  CAS Number: CAS 302962-49-8
  TTD Drug ID: DMJV2EK
  VARIDT Drug ID: DR00182
  INTEDE Drug ID: DR0423
  ACDINA Drug ID: D00171

Molecule-Related Drug Atlas

Drug(s) Targeting LCK tyrosine protein kinase (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[5]
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[14]
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[15]
Bisindolylmaleimide-I	DMOQJZC	Discovery agent	N.A.	Investigative	[15]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[16]
CI-1040	DMF3DZX	Discovery agent	N.A.	Investigative	[15]
AMP-PNP	DMTOK1D	Discovery agent	N.A.	Investigative	[17]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[18]
KN-62	DMLZ89P	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting Fyn tyrosine protein kinase (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
JNJ-26483327	DMSQ3AZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[19]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[20]
PMID15546730C2	DMOPUIH	Discovery agent	N.A.	Investigative	[21]
CEP-5104	DMV43GY	Discovery agent	N.A.	Investigative	[22]
CEP-6331	DMNXBTD	Discovery agent	N.A.	Investigative	[22]
JNJ-10198409	DM9GDP5	Discovery agent	N.A.	Investigative	[23]
1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane	DMD7WNV	Discovery agent	N.A.	Investigative	[24]

Drug(s) Targeting Fusion protein Bcr-Abl (Bcr-Abl)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[5]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[25]
Asciminib	DM7EVUF	Chronic myeloid leukaemia	2A20	Approved	[26]
Radotinib	DMWA74Y	leukaemia	2A60-2B33	Phase 3	[27]
ABL 001	DMMF5K4	Chronic myeloid leukaemia	2A20	Phase 3	[28]
ICLUSIG	DM1SQSE	Acute lymphoblastic leukaemia	2A85	Phase 3	[29]
Bafetinib	DM7586F	Bone disease	FC0Z	Phase 2	[30]
AN-019	DMJ7QP8	Chronic myelogenous leukaemia	2A20.0	Phase 2	[31]
HQP1351	DMQ30X2	Chronic myeloid leukaemia	2A20	Phase 2	[32]
NPB-001-056	DM78KMT	Chronic myelogenous leukaemia	2A20.0	Phase 1/2	[33]

Drug(s) Targeting Proto-oncogene c-Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[5]
SKI-758	DMQ8E9R	Ischemia	8B10-8B11	Approved	[34]
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[35]
AL3818	DM3WP0N	Alveolar soft part sarcoma	2A60-2C35	Phase 3	[36]
CP-868596	DMZIM37	Gastrointestinal cancer	2C11	Phase 3	[36]
Masitinib	DMRSNEU	Amyotrophic lateral sclerosis	8B60.0	Phase 3	[37]
KX-01	DMF0NA9	Actinic keratosis	EK90.0	Phase 3	[38]
Saracatinib	DMBLHGP	Hematologic tumour	2B33.Y	Phase 2	[39]
TPX-0046	DMIVE67	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[40]
ISIS-CRP	DMQDUG4	Cardiovascular disease	BA00-BE2Z	Phase 1	[14]

Drug(s) Targeting HUMAN fusion protein Bcr-Abl (Bcr-Abl)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[4]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[44]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[45]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[46]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[47]

Drug(s) Transported By Breast cancer resistance protein (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[50]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[51]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[52]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[55]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[56]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[7]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[59]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[7]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[60]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[61]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[62]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[63]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[60]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[7]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[65]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[66]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[7]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[67]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[61]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[63]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[68]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[63]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[69]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[70]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[71]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[73]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[70]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[77]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[78]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[79]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[80]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[82]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[75]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[84]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[86]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[91]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[92]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[94]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[95]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[90]

Drug(s) Metabolized By Dimethylaniline oxidase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethionamide	DM8K3EI	Pulmonary tuberculosis	1B10.Z	Approved	[96]
Almotriptan malate	DMFG5ST	N. A.	N. A.	Approved	[97]
Fedratinib hydrochloride	DML2DCR	N. A.	N. A.	Approved	[98]
Itopride	DM7MLTR	N. A.	N. A.	Phase 3	[99]
HSR-803	DMAVIPZ	N. A.	N. A.	Phase 3	[99]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[104]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[109]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[113]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[116]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[117]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[125]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[100]

Drug(s) Affected By CD63 antigen (CD63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[128]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[132]

Drug(s) Affected By Tyrosine-protein kinase Fgr (FGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[135]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[147]

Drug(s) Affected By Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Tyrosine-protein kinase CSK (CSK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[158]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[159]

Drug(s) Affected By Tyrosine-protein kinase Tec (TEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[163]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[164]

Drug(s) Affected By Tyrosine-protein kinase FRK (FRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Ephrin type-A receptor 5 (EPHA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[173]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Ephrin type-B receptor 4 (EPHB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[176]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]

Drug(s) Affected By Sialomucin core protein 24 (CD164)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Amidophosphoribosyltransferase (PPAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[198]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 20 (MAP3K20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[201]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[202]

Drug(s) Affected By ATP-dependent RNA helicase DDX39A (DDX39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[209]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Nuclear envelope integral membrane protein 1 (NEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By Kinetochore protein NDC80 homolog (NDC80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC7 (POLR3G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By Fanconi anemia group A protein (FANCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[230]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[231]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[234]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[237]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[242]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[243]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[249]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[250]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[251]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[208]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[252]

Drug(s) Affected By NUAK family SNF1-like kinase 1 (NUAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[135]

Drug(s) Affected By Neuropilin-2 (NRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[255]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[220]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[220]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[256]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Tetraspanin-2 (TSPAN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Leupaxin (LPXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[264]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]

Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By DNA polymerase theta (POLQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Glypican-4 (GPC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Serpin B7 (SERPINB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[252]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[271]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[272]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[271]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[273]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[275]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Ribonuclease H2 subunit A (RNASEH2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[277]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[278]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Centrosomal protein of 152 kDa (CEP152)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By Potassium channel subfamily K member 2 (KCNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[283]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[284]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Chromosome-associated kinesin KIF4A (KIF4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Structural maintenance of chromosomes protein 2 (SMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[287]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[290]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[292]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[294]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[297]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Securin (PTTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[299]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD2 (NSD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[301]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[306]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[312]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Complement C1r subcomponent (C1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[314]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[318]

Drug(s) Affected By Alpha-2-macroglobulin (A2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[319]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[320]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[321]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[320]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[323]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[328]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[329]
Bortezomib	DMNO38U	Leukemia		Approved	[330]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[331]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[332]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[333]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[334]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[336]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[337]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[338]

Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[341]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[135]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[344]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[345]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[346]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[350]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[351]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[353]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[355]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[359]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[361]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[364]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[336]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[366]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[367]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[368]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[370]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[371]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[372]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[373]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[378]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[380]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Neurofilament medium polypeptide (NEFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[382]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[386]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[386]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[387]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[386]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]

Drug(s) Affected By Matrix Gla protein (MGP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[389]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[390]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[339]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Complement C1s subcomponent (C1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[393]

Drug(s) Affected By Histone H2A.Z (H2AZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[394]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[395]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[396]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[397]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[395]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[398]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[400]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[399]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[390]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[390]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[403]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Histone H1.4 (H1-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[407]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[408]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[408]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[258]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[409]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[408]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[410]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[412]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[413]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[414]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]

Drug(s) Affected By Fibroblast growth factor 5 (FGF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[416]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[417]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[418]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[419]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[249]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[249]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[420]
Suramin	DMTOUY9	African trypanosomiasis	1F51	Phase 1	[421]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Collagen alpha-1(XI) chain (COL11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[274]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[258]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[422]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[416]

Drug(s) Affected By Elastin (ELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[423]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[346]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[424]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[425]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]

Drug(s) Affected By Aggrecan core protein (ACAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[426]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[427]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[428]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[429]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[430]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[431]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Histone H1.5 (H1-5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[436]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[325]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Biglycan (BGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[438]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[440]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[443]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[444]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[445]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[446]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[447]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[438]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[450]

Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[451]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[452]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[372]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Selenium	DM25CGV	N. A.	N. A.	Approved	[373]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[458]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[459]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[460]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[461]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[462]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Bortezomib	DMNO38U	Leukemia		Approved	[463]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[464]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[465]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]

Drug(s) Affected By Cardiac phospholamban (PLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[466]
Manganese	DMKT129	N. A.	N. A.	Investigative	[467]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[461]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Dipeptidyl peptidase 4 (DPP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saxagliptin	DMGXENV	Type-2 diabetes	5A11	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Alogliptin	DM8WI3R	Type-2 diabetes	5A11	Approved	[470]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[159]
Anagliptin	DMJXIC9	Type-2 diabetes	5A11	Approved	[471]

Drug(s) Affected By Leiomodin-1 (LMOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[472]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[473]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[474]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[476]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[477]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[479]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[480]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[481]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[482]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[451]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]

Drug(s) Affected By Fibroblast growth factor 9 (FGF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[483]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[416]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[485]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[220]

Drug(s) Affected By Sodium- and chloride-dependent taurine transporter (SLC6A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[486]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[487]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]

Drug(s) Affected By Histone H2B type 1-B (H2BC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[488]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Dual specificity protein kinase TTK (TTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Syndecan-2 (SDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[341]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[491]

Drug(s) Affected By Replication factor C subunit 4 (RFC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Replication factor C subunit 2 (RFC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[492]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]

Drug(s) Affected By Myosin-10 (MYH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[493]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[496]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[422]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[497]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Chitinase-3-like protein 1 (CHI3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[498]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[499]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[374]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[503]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Nicotinamide N-methyltransferase (NNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[504]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[505]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[287]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[287]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[506]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[507]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 1 (PBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[287]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[508]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[509]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[510]
Bortezomib	DMNO38U	Leukemia		Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[512]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[514]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[515]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[516]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[516]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[514]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[514]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[518]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]

Drug(s) Affected By Condensin-2 complex subunit D3 (NCAPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]

Drug(s) Affected By Neutral amino acid transporter A (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[231]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[336]
Haloperidol	DM96SE0	Delirium		Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[519]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[521]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[522]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[523]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[525]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]

Drug(s) Affected By Glutathione S-transferase Mu 5 (GSTM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[526]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[149]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]

Drug(s) Affected By Histone H3-like centromeric protein A (CENPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By DNA primase small subunit (PRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By DNA primase large subunit (PRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Thrombospondin-3 (THBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[278]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[529]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[365]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[365]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[365]

Drug(s) Affected By Selenoprotein P (SELENOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[531]

Drug(s) Affected By Kinetochore-associated protein 1 (KNTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[532]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Ras association domain-containing protein 2 (RASSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[533]
Indomethacin	DMSC4A7	Bursitis		Approved	[534]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]

Drug(s) Affected By DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[463]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Lumican (LUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[510]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[536]

Drug(s) Affected By Calponin-1 (CNN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[496]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[537]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[538]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[539]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[540]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[109]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[541]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Microfibril-associated glycoprotein 4 (MFAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[536]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[543]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 1 (CKS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[545]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[136]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[393]

Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[546]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[547]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[376]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[548]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[549]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[550]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[551]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[552]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[322]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[184]

Drug(s) Affected By Actin, alpha cardiac muscle 1 (ACTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[554]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[555]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Methamphetamine	DMPM4SK	Anxiety		Approved	[556]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[555]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[557]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[558]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[559]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Histone H1.1 (H1-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[560]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[561]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[562]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[258]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[378]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[564]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[565]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[566]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]

Drug(s) Affected By Prolow-density lipoprotein receptor-related protein 1 (LRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[567]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[568]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[569]

Drug(s) Affected By Lactadherin (MFGE8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[255]
Methyl aminolevulinate	DMIUX3D	Acne vulgaris	ED80	Approved	[570]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[486]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[571]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[365]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[365]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[572]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]

Drug(s) Affected By Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[574]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By MAL-like protein (MALL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[532]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[575]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[576]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[577]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[578]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Centromere protein R (ITGB3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[575]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[580]

Drug(s) Affected By Limbic system-associated membrane protein (LSAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[581]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]

Drug(s) Affected By Four and a half LIM domains protein 1 (FHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[582]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[532]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[211]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[583]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[584]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[187]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[585]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[586]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[587]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[473]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[588]

Drug(s) Affected By DNA polymerase alpha subunit B (POLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Fibroleukin (FGL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[589]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[590]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[591]

Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[487]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[592]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[589]

Drug(s) Affected By Semaphorin-3A (SEMA3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[593]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[595]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Maternal embryonic leucine zipper kinase (MELK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By DNA replication complex GINS protein PSF1 (GINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[266]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Haloperidol	DM96SE0	Delirium		Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[596]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Condensin complex subunit 1 (NCAPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[135]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]

Drug(s) Affected By SCL-interrupting locus protein (STIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By Pachytene checkpoint protein 2 homolog (TRIP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[376]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[597]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[598]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[599]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[600]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[602]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Prostacyclin synthase (PTGIS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[603]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
NAFAZATROM	DM31CV2	N. A.	N. A.	Terminated	[158]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[604]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[605]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[395]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[606]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[607]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[608]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[609]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[610]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[367]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[287]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[611]

Drug(s) Affected By Tumor protein D53 (TPD52L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]

Drug(s) Affected By Flap endonuclease GEN homolog 1 (GEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[612]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[612]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]

Drug(s) Affected By Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Indomethacin	DMSC4A7	Bursitis		Approved	[613]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[614]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]

Drug(s) Affected By Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[543]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[580]

Drug(s) Affected By Protein LBH (LBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[105]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]

Drug(s) Affected By Shugoshin 2 (SGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Centromere protein W (CENPW)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[615]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]

Drug(s) Affected By Shugoshin 1 (SGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC4 (HERC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[616]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[617]

Drug(s) Affected By Testis-expressed protein 30 (TEX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]

Drug(s) Affected By DEP domain-containing protein 1A (DEPDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Tensin-3 (TNS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[618]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Protein FAM72D (FAM72D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]

Drug(s) Affected By Repulsive guidance molecule B (RGMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[441]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]

Drug(s) Affected By STEAP family member 1B (STEAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[253]

Drug(s) Affected By Mis18-binding protein 1 (MIS18BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Mitochondrial fission regulator 2 (MTFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Rho GTPase-activating protein 11A (ARHGAP11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]

Drug(s) Affected By E3 ubiquitin-protein ligase RFWD3 (RFWD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Podocan-like protein 1 (PODNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[163]

Drug(s) Affected By Protein aurora borealis (BORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[248]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Neutral cholesterol ester hydrolase 1 (NCEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By Fidgetin-like protein 1 (FIGNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[211]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By ATPase family AAA domain-containing protein 2 (ATAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[619]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[135]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Serine protease FAM111B (FAM111B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[580]

Drug(s) Affected By Protein FAM180A (FAM180A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[163]

Drug(s) Affected By Golgi-associated kinase 1B (GASK1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Plexin domain-containing protein 2 (PLXDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[510]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[486]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[620]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[621]

Drug(s) Affected By ALK and LTK ligand 1 (ALKAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Protein MMS22-like (MMS22L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[170]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[622]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[623]

Drug(s) Affected By Centrosomal protein of 128 kDa (CEP128)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[622]

Drug(s) Affected By DNA-binding protein RFX8 (RFX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[624]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Centromere protein U (CENPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Treslin (TICRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By MAM domain-containing protein 2 (MAMDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[625]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By LisH domain-containing protein ARMC9 (ARMC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[626]

Drug(s) Affected By Rho GTPase-activating protein 22 (ARHGAP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]

Drug(s) Affected By Podocan (PODN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[627]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[252]

Drug(s) Affected By Schlafen family member 11 (SLFN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[543]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[253]

Drug(s) Affected By Amphoterin-induced protein 2 (AMIGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[365]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[365]

Drug(s) Affected By Alpha-protein kinase 2 (ALPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[105]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[159]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Myopalladin (MYPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[300]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[160]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[628]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[473]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[543]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP3 (IQGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]

Drug(s) Affected By Condensin-2 complex subunit G2 (NCAPG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By GAS2-like protein 3 (GAS2L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Histone H2A type 2-B (H2AC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[163]

Drug(s) Affected By Pleckstrin homology domain-containing family H member 2 (PLEKHH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]

Drug(s) Affected By Extracellular sulfatase Sulf-2 (SULF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Extracellular sulfatase Sulf-1 (SULF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[593]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]

Drug(s) Affected By CD302 antigen (CD302)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[472]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]

Drug(s) Affected By Spindle and kinetochore-associated protein 3 (SKA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[214]

Drug(s) Affected By DNA damage-induced apoptosis suppressor protein (DDIAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Cytoskeleton-associated protein 2-like (CKAP2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]

Drug(s) Affected By Fanconi anemia group M protein (FANCM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[629]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[300]

Drug(s) Affected By Lung adenoma susceptibility protein 2 (C18ORF54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[629]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[432]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[559]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Drug(s) Affected By Retinol dehydrogenase 10 (RDH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[278]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[584]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]

Drug(s) Affected By Centromere protein L (CENPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[630]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Rho GTPase-activating protein 18 (ARHGAP18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By T-complex protein 11-like protein 2 (TCP11L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[621]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]

Drug(s) Affected By Aminopeptidase O (AOPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[622]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]

Drug(s) Affected By Junction-mediating and -regulatory protein (JMY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]

Drug(s) Affected By Holliday junction recognition protein (HJURP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Methamphetamine	DMPM4SK	Anxiety		Approved	[556]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By MAM domain-containing glycosylphosphatidylinositol anchor protein 1 (MDGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]

Drug(s) Affected By (Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[135]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[221]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[631]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[486]

Drug(s) Affected By Protein CIP2A (CIP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[632]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[633]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]

Drug(s) Affected By DEP domain-containing protein 1B (DEPDC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Basic helix-loop-helix ARNT-like protein 2 (BMAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[102]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Centromere protein I (CENPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[211]

Drug(s) Affected By Serine protease HTRA1 (HTRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[635]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Tirbanibulin	DMJNV4O	Actinic keratosis	EK90.0	Approved	[635]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[635]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[635]

Drug(s) Affected By Hyaluronan synthase 2 (HAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[636]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[491]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[637]

Drug(s) Affected By Neogenin (NEO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[638]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]

Drug(s) Affected By Histone H2B type 1-H (H2BC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[639]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[639]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[135]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Transcription factor E2F7 (E2F7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Spindle and kinetochore-associated protein 1 (SKA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Mdm2-binding protein (MTBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[641]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Sororin (CDCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[642]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]

Drug(s) Affected By Serine/threonine-protein kinase greatwall (MASTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[188]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Centromere protein N (CENPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[395]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[643]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[159]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[395]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Proline-rich protein 11 (PRR11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[644]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Leucine-rich repeat protein 1 (LRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[645]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[646]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[629]

Drug(s) Affected By Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[531]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[184]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[220]

Drug(s) Affected By Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[647]

Drug(s) Affected By ATPase family AAA domain-containing protein 5 (ATAD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[646]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Hemicentin-1 (HMCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[649]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[649]

Drug(s) Affected By Hyaluronan and proteoglycan link protein 3 (HAPLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[486]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[650]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[269]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[651]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[652]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]

Drug(s) Affected By Cell division cycle-associated protein 3 (CDCA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[493]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[653]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[654]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[654]

Drug(s) Affected By Histone H2B type 1-M (H2BC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[655]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[406]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[656]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Mitochondrial genome maintenance exonuclease 1 (MGME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[102]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[300]

Drug(s) Affected By Synaptotagmin-15 (SYT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[657]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[658]

Drug(s) Affected By Hephaestin (HEPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[249]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[220]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By DNA replication complex GINS protein SLD5 (GINS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Centromere protein K (CENPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Protein PIMREG (PIMREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]

Drug(s) Affected By Nucleoporin NDC1 (NDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[659]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[622]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[300]

Drug(s) Affected By Centromere protein O (CENPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[264]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[629]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[639]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[660]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[631]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[660]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[661]

Drug(s) Affected By TIMELESS-interacting protein (TIPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[475]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[475]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[475]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[475]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Meiotic nuclear division protein 1 homolog (MND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[311]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[662]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]

Drug(s) Affected By Transmembrane 6 superfamily member 1 (TM6SF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[639]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[639]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[267]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[639]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[661]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[212]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[663]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[664]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Centromere protein H (CENPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Kinetochore-associated protein DSN1 homolog (DSN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Uncharacterized protein C1orf198 (C1ORF198)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[615]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[628]

Drug(s) Affected By Golgi-associated plant pathogenesis-related protein 1 (GLIPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[650]

Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[665]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Anthrax toxin receptor 1 (ANTXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]

Drug(s) Affected By Gremlin-2 (GREM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[274]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[473]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]

Drug(s) Affected By Metal transporter CNNM2 (CNNM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[204]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Protein ECT2 (ECT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Claspin (CLSPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]

Drug(s) Affected By Mineralization regulator ANKH (ANKH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]

Drug(s) Affected By Ribonucleoprotein PTB-binding 2 (RAVER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[627]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[666]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[220]

Drug(s) Affected By Neurexin-3-beta (NRXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[536]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[542]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[220]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]

Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[667]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[668]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Phospholipid scramblase 4 (PLSCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[621]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]

Drug(s) Affected By Lymphoid-specific helicase (HELLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By FIGNL1-interacting regulator of recombination and mitosis (FIRRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[646]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]

Drug(s) Affected By Protein diaphanous homolog 3 (DIAPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[386]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[387]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[386]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[386]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[387]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[387]

Drug(s) Affected By Tyrosyl-DNA phosphodiesterase 1 (TDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[669]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Fanconi anemia group I protein (FANCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[662]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]

Drug(s) Affected By Histone chaperone ASF1B (ASF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[580]

Drug(s) Affected By PCNA-interacting partner (PARPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[670]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]

Drug(s) Affected By Dapper homolog 1 (DACT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[638]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]

Drug(s) Affected By Protein Mis18-alpha (MIS18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[210]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[671]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[672]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[673]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[525]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[674]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By LIM and cysteine-rich domains protein 1 (LMCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[510]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[615]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[646]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[513]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[675]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[596]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[475]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[392]

Drug(s) Affected By Fibulin-5 (FBLN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Bortezomib	DMNO38U	Leukemia		Approved	[211]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[511]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[676]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[594]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]

Drug(s) Affected By STEAP1 protein (STEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Carboxypeptidase A4 (CPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]

Drug(s) Affected By DNA helicase MCM8 (MCM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[677]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By Angiopoietin-related protein 2 (ANGPTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[473]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]

Drug(s) Affected By Integrin alpha-11 (ITGA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[601]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Protein HEG homolog 1 (HEG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Synaptopodin-2 (SYNPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[417]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[261]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[678]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[678]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[426]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[679]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[220]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[189]

Drug(s) Affected By Protein timeless homolog (TIMELESS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By LIM and calponin homology domains-containing protein 1 (LIMCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[638]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Exonuclease 1 (EXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[105]

Drug(s) Affected By Transcription factor 19 (TCF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By DNA replication complex GINS protein PSF2 (GINS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[215]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Serine/threonine-protein kinase 38-like (STK38L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[114]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[149]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Small kinetochore-associated protein (KNSTRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[286]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By Origin recognition complex subunit 6 (ORC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[111]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[135]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[680]

Drug(s) Affected By Carboxypeptidase Q (CPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[681]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[650]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 3 (TACC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[299]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[299]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 1 (IRAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[313]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[439]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[285]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[658]

Drug(s) Affected By Adenylate kinase isoenzyme 5 (AK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[593]
Methamphetamine	DMPM4SK	Anxiety		Approved	[682]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[420]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[683]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[684]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[685]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[685]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[686]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[684]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[685]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[687]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[684]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[688]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[684]

Drug(s) Affected By Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[689]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[100]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[690]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[691]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[692]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[693]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[694]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[695]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[696]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[697]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[698]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[699]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[700]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[701]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[701]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[702]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[703]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[704]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[705]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[706]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[165]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[707]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[479]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[708]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[709]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[696]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[710]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[711]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[712]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[713]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[714]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[715]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[716]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[412]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[717]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[226]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[718]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[457]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[475]

Drug(s) Affected By cAMP-regulated phosphoprotein 19 (ARPP19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[619]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[719]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[120]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[720]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[721]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[722]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[723]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[724]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[158]
Anagrelide	DMSQ8MD	Thrombocythemia	3B63	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[725]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[726]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[727]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[728]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[729]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[730]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[373]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[715]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[731]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[732]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[733]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[734]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[735]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[736]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[737]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[738]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[739]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[740]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[741]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[742]
Fructose	DM43AN2	Vomiting	MD90	Approved	[158]
Ketoprofen	DMRKXPT	Bursitis		Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[743]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[745]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[746]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[747]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[663]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[748]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[749]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[750]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[751]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[752]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[753]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[754]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[755]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[748]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[756]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[757]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[758]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[579]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[759]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[760]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[762]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[763]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[764]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[765]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[766]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[767]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[768]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[605]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[769]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[770]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[771]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[772]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[773]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[774]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[748]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[775]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[776]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[738]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[777]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[778]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[779]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[780]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[781]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[782]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[783]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[784]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[785]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[786]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[787]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[390]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[788]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[789]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[790]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[790]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[790]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[790]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[791]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[601]
Selenium	DM25CGV	N. A.	N. A.	Approved	[461]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[258]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[365]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[325]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[792]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[793]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[794]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[795]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[796]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[797]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[798]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[367]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[799]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[363]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[790]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[800]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[801]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[790]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[802]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[803]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[804]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[804]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[368]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[805]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[806]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[807]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[808]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[809]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[810]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[710]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[811]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[812]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[813]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[814]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[815]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[816]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[817]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[818]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[813]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[819]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Breakpoint cluster region protein (BCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[173]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Bortezomib	DMNO38U	Leukemia		Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[802]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[803]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[804]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[804]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[368]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[821]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[369]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[737]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[432]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[822]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[823]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[756]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[412]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[824]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[748]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[825]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[757]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[803]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[826]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[827]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[827]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]

Drug(s) Affected By Platelet-derived growth factor receptor alpha (PDGFRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[828]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[829]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[830]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[831]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[832]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[473]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[833]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[834]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[835]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[836]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[837]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[838]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[839]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[710]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[500]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[840]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[717]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[841]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[715]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[842]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[843]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[844]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[845]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[846]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[847]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[848]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[849]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[850]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[851]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[852]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[844]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[853]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[854]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[855]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[843]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[846]

Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[856]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[857]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[858]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[859]
Bortezomib	DMNO38U	Leukemia		Approved	[211]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[857]
Novobiocin	DMRFWGK	Bacterial infection	1A00-1C4Z	Approved	[860]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[201]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[840]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[861]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[862]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[863]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[545]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[566]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[864]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[865]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[866]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[867]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[868]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[554]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[123]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[869]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[870]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[871]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[872]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[873]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[874]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[875]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[876]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[734]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[877]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[878]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[705]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[715]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[879]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[880]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[881]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[882]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[883]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[884]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[693]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[885]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[886]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[887]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[888]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[889]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[890]

Drug(s) Affected By Tyrosine-protein kinase ABL2 (ABL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[161]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[621]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[115]

Drug(s) Affected By Crk-like protein (CRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[727]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[891]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[892]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[893]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[641]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[894]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[895]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[896]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[840]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[718]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[897]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[898]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[899]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[900]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[544]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[901]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[902]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[398]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[903]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[220]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[398]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[904]

Drug(s) Affected By Paxillin (PXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[300]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[905]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[118]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[906]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[907]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[908]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[909]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[910]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[911]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[911]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[436]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[912]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[414]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[913]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[914]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[362]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[810]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[915]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[916]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[917]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[918]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[919]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[158]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[737]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[776]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[920]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[921]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[922]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[778]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[780]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[923]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[924]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[925]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[926]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[927]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[928]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[929]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[930]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[931]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[708]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[932]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[933]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[934]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[935]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[535]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[936]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[937]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[479]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[938]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[255]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[847]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[939]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[940]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[941]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[942]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[943]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[944]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[639]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[945]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[639]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[639]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[263]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[510]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[187]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[696]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[946]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[947]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[948]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[949]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[339]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[950]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[459]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[951]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[802]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[339]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[952]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[953]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[954]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[955]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[956]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[957]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[958]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[918]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[530]

Drug(s) Affected By Pre-mRNA 3'-end-processing factor FIP1 (FIP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[178]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[621]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[528]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[162]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[959]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[960]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[961]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[378]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[959]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[960]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[962]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]

Drug(s) Affected By Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (PKMYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[199]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[106]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[963]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[963]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[963]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[963]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[963]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[963]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[964]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[963]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[486]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[225]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[965]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[966]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[967]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[968]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[840]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[969]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[899]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[970]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[971]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[972]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[973]

Drug(s) Affected By Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[126]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[928]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[129]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[290]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[553]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[199]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[166]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fusion protein Bcr-Abl (Bcr-Abl)	TTS7G69	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[5]
Fyn tyrosine protein kinase (FYN)	TT2B9KF	FYN_HUMAN	Inhibitor	[5]
LCK tyrosine protein kinase (LCK)	TT860QF	LCK_HUMAN	Inhibitor	[5]
Proto-oncogene c-Src (SRC)	TT6PKBN	SRC_HUMAN	Inhibitor	[5]
HUMAN fusion protein Bcr-Abl (Bcr-Abl)	TTE63HY	BCR_HUMAN/ABL1_HUMAN	Inhibitor	[4]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[6]
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[7]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[7]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[8]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[9]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[9]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[9]
Dimethylaniline oxidase 3 (FMO3)	DEP76YL	FMO3_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Gene/Protein Processing	[11]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Gene/Protein Processing	[11]
A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)	OT953SV2	ATS5_HUMAN	Gene/Protein Processing	[11]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Gene/Protein Processing	[11]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Gene/Protein Processing	[11]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[11]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Gene/Protein Processing	[11]
Adenylate kinase isoenzyme 5 (AK5)	OTTGXLOT	KAD5_HUMAN	Gene/Protein Processing	[11]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Gene/Protein Processing	[12]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Gene/Protein Processing	[11]

References

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