Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCGWBJ)

• Drug Name: Epigallocatechin gallate Drug Info
• Synonyms: (-)-Epigallocatechin gallate; EGCG; 989-51-5; Epigallocatechin 3-gallate; Epigallocatechin-3-gallate; Tea catechin; (-)-Epigallocatechin-3-o-gallate; Teavigo; Epigallocatechin-3-monogallate; (-)-Epigallocatechol gallate; (2R,3R)-5,7-Dihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-3-yl 3,4,5-trihydroxybenzoate; Catechin deriv; UNII-BQM438CTEL; Green tea extract; CCRIS 3729; (-)-epigallocatechin 3-gallate; C22H18O11; BQM438CTEL; (2R,3R)-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-chromen-3-yl; EGCG analogs; EGCG, Anagen; Epigallocatechin gallate analogs, Anagen; Epigallocatechin gallate, Anagen; GTPs,Anagen; Green tea polyphenols, Anagen; EPIGALOCATECHIN GALLATE

Indication

Disease Entry	ICD 11	Status	REF
Hepatic fibrosis	DB93.0	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 65064
  ChEBI ID: CHEBI:4806
  CAS Number: CAS 989-51-5
  TTD Drug ID: DMCGWBJ

Molecule-Related Drug Atlas

Drug(s) Targeting Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[12]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[13]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[14]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[15]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[13]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[16]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[17]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[16]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[16]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[18]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[19]

Drug(s) Targeting Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[20]
TVB-2640	DM19GUH	Astrocytoma	2A00.0Y	Phase 2	[21]
TVB-2640	DM19GUH	Astrocytoma	2A00.0Y	Phase 2	[22]
FAS1	DMAX2EW	Fungal infection	1F29-1F2F	Preclinical	[23]
FSA2	DMLNRCI	Fungal infection	1F29-1F2F	Preclinical	[23]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[12]

Drug(s) Targeting Neutrophil elastase (NE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sivelestat sodium hydrate	DMOSJD0	Acute lung injury	NB32.3	Phase 4	[24]
Sivelestat	DM6BZCV	Crohn disease	DD70	Phase 3	[25]
Tiprelestat	DM1SB94	Myocardial infarction	BA41-BA43	Phase 2	[26]
AZD9668	DMB87M3	Bronchiectasis	CA24	Phase 2	[27]
L-694,458	DMA0DSJ	Cystic fibrosis	CA25	Phase 2	[28]
BAY 85-8501	DMCPUKG	Bronchiectasis	CA24	Phase 2	[29]
DX-890	DMBFZET	Acute lung injury	NB32.3	Phase 2	[24]
POL-6014	DM9B68S	Cystic fibrosis	CA25	Phase 1	[30]
AZD-9819	DMWYHXG	Chronic obstructive pulmonary disease	CA22	Phase 1	[31]
BI 1323495	DMAUKTS	Chronic obstructive pulmonary disease	CA22	Phase 1	[32]

Drug(s) Targeting Plasmodium Enoyl-ACP reductase (Malaria fabI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[33]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[34]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[34]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
Thiolactomycin	DMBAWDG	Malaria	1F40-1F45	Investigative	[33]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]
Diazaborines	DM5UFZX	Discovery agent	N.A.	Investigative	[35]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[2]

Drug(s) Targeting Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[2]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[2]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[2]
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[2]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[12]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[2]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[2]
NADPH	DM75Q34	Discovery agent	N.A.	Investigative	[36]

Drug(s) Targeting Matrix metalloproteinase-14 (MMP-14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BT1718	DMTXBUV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2a	[37]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[38]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[39]
IK-862	DMJA4UE	Discovery agent	N.A.	Investigative	[40]
SR-973	DMU48OD	Discovery agent	N.A.	Investigative	[41]
2-(Biphenyl-4-ylsulfonyl)N-hydroxybenzamide	DMCNV5J	Discovery agent	N.A.	Investigative	[42]
[2-(Biphenyl-4-sulfonyl)phenyl]acetic Acid	DM37C25	Discovery agent	N.A.	Investigative	[42]
N-Hydroxy-2-(4-phenoxy-benzenesulfonyl)benzamide	DM4VADN	Discovery agent	N.A.	Investigative	[42]
UK-356618	DM02FGH	Discovery agent	N.A.	Investigative	[43]
PMID23631440C29e	DMM92IB	Discovery agent	N.A.	Investigative	[44]

Drug(s) Targeting Matrix metalloproteinase-2 (MMP-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prinomastat	DM9HOKG	Lung cancer	2C25.0	Approved	[45]
Marimastat	DM6V34C	Pancreatic cancer	2C10	Phase 3	[46]
Neovastat	DMXTYWJ	Non-small-cell lung cancer	2C25.Y	Phase 1	[47]
Metastat	DMTQ4PN	Acne vulgaris	ED80	Phase 1	[48]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[49]
PMID29130358-Compound-Figure10(2a)	DMFWXPS	N. A.	N. A.	Patented	[49]
PMID29130358-Compound-Figure16(9b)	DMPAQLZ	N. A.	N. A.	Patented	[49]
PMID29130358-Compound-SB-3CT	DMC64XQ	N. A.	N. A.	Patented	[49]
PMID29130358-Compound-Figure16(9a)	DMKX5R8	N. A.	N. A.	Patented	[49]
PMID29130358-Compound-Figure18(14)	DM7WXJ9	N. A.	N. A.	Patented	[49]

Drug(s) Targeting Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Naftifine	DMHVBG1	Dermatomycosis	EA60	Approved	[50]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[51]
FR-194738	DMNACIV	Hypercholesterolaemia	5C80.0	Terminated	[52]
SDZ-87-469	DMBY6CQ	Coronary artery disease	BA80	Terminated	[51]
NB-598	DMJVTQN	N. A.	N. A.	Terminated	[53]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[7]
1,2,3,4,6-penta-O-galloyl-beta-D-glucose	DMTK650	Discovery agent	N.A.	Investigative	[7]
Pedunculagin	DMKLRCX	Discovery agent	N.A.	Investigative	[7]
CORILAGIN	DMAC698	Discovery agent	N.A.	Investigative	[7]
ETHYLGALLATE	DMJ6PB8	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[55]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Tetraspanin-6 (TSPAN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By Rho-related BTB domain-containing protein 1 (RHOBTB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[93]

Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[95]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[98]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[104]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Bisphosphoglycerate mutase (BPGM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[112]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[113]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[115]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[120]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[121]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[125]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[127]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[128]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[129]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[130]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[135]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]

Drug(s) Affected By Carboxypeptidase E (CPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Gap junction alpha-4 protein (GJA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[146]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[147]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[148]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[150]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[151]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[152]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[155]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[157]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]

Drug(s) Affected By Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[169]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[157]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[170]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[174]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Cadherin-13 (CDH13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
Methamphetamine	DMPM4SK	Anxiety		Approved	[186]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[187]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[194]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]

Drug(s) Affected By Death domain-containing protein CRADD (CRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[201]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[169]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[200]

Drug(s) Affected By Interleukin-10 receptor subunit beta (IL10RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[207]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]

Drug(s) Affected By Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[210]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[212]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]

Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[222]

Drug(s) Affected By Metal cation symporter ZIP14 (SLC39A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[225]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Filamin A-interacting protein 1-like (FILIP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Interleukin-27 receptor subunit alpha (IL27RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]

Drug(s) Affected By Ecto-ADP-ribosyltransferase 4 (ART4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Modulator of apoptosis 1 (MOAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Haloperidol	DM96SE0	Delirium		Approved	[211]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]

Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[243]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Serine/threonine-protein kinase pim-2 (PIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By PTB domain-containing engulfment adapter protein 1 (GULP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[246]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]

Drug(s) Affected By Rho-related GTP-binding protein RhoD (RHOD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[253]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[254]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[255]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[257]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[263]
Selenium	DM25CGV	N. A.	N. A.	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[269]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[270]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[271]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[272]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[273]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[274]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[275]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[276]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[277]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[278]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[276]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[279]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[280]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[280]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[281]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[283]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[284]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[286]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[290]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[291]

Drug(s) Affected By Thymidylate kinase (DTYMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[233]

Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[296]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[297]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[298]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[299]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[300]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[301]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[188]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[303]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[305]

Drug(s) Affected By Cyclin-G1 (CCNG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[308]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[287]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[310]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[311]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[312]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[313]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[314]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[315]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[316]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[301]

Drug(s) Affected By Histone-binding protein RBBP4 (RBBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]

Drug(s) Affected By Major vault protein (MVP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]

Drug(s) Affected By Ras-related protein Rab-11B (RAB11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[319]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[320]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[241]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[169]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[327]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[328]

Drug(s) Affected By Rab9 effector protein with kelch motifs (RABEPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[329]

Drug(s) Affected By ATP-binding cassette sub-family B member 10, mitochondrial (ABCB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[331]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[332]

Drug(s) Affected By Heat shock protein beta-7 (HSPB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[334]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[336]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[337]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[338]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[339]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[340]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[224]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[343]

Drug(s) Affected By Histone deacetylase 5 (HDAC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[345]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[346]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[347]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[351]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[352]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[353]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[354]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[355]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[356]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[359]
Fructose	DM43AN2	Vomiting	MD90	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[361]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[362]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[364]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]

Drug(s) Affected By Zinc transporter ZIP4 (SLC39A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[366]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Zinc transporter ZIP1 (SLC39A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[226]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[367]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[369]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]

Drug(s) Affected By Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 (PLOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[11]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[11]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[11]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[11]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[371]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[372]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[373]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[375]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[376]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[377]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[373]

Drug(s) Affected By Pro-opiomelanocortin (POMC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[378]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[379]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[380]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[381]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[382]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[383]
Triamcinolone	DM98IXF	Acute adrenal insufficiency		Approved	[384]
Buspirone	DMBS632	Anxiety disorder	6B00-6B0Z	Approved	[385]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[386]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[387]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[153]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[115]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[392]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[393]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[395]

Drug(s) Affected By Fibroblast growth factor 1 (FGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[397]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[217]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[398]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[400]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[401]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[402]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[403]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[404]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[405]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[409]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[410]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[412]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[412]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[412]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[413]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[398]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[415]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[416]
Selenium	DM25CGV	N. A.	N. A.	Approved	[417]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[418]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[419]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[420]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[422]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[424]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[425]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[431]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[235]

Drug(s) Affected By 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[432]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[433]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[434]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[435]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[436]
Methyltestosterone	DMWLFGO	Advanced cancer	2A00-2F9Z	Approved	[434]
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[434]

Drug(s) Affected By Desmoglein-3 (DSG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[437]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[438]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[11]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[11]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[439]

Drug(s) Affected By Prostaglandin E2 receptor EP1 subtype (PTGER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[11]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[11]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[11]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Fibrillin-1 (FBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[440]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Fibrillin-2 (FBN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[444]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[445]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[447]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[448]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[451]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[452]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[212]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[453]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[454]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[308]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[373]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[455]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[11]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[11]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[11]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[11]

Drug(s) Affected By Cytoglobin (CYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[456]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[80]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[461]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[462]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[463]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[465]
Mestranol	DMG3F94	Contraception	QA21	Approved	[466]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[467]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[468]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[11]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[11]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[11]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[469]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[11]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[11]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[470]

Drug(s) Affected By Klotho (KL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[471]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[472]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[473]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[11]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[11]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[11]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[11]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[285]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[153]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[476]
Selenium	DM25CGV	N. A.	N. A.	Approved	[477]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[478]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[479]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[480]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[481]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[482]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[483]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[484]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[485]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[486]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[487]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[488]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[489]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[490]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[200]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[491]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[492]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[493]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[495]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[496]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[498]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[499]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[500]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[338]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[502]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[503]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[505]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[506]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[507]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[508]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[509]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[510]

Drug(s) Affected By SH3 and PX domain-containing protein 2B (SH3PXD2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[511]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[512]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[513]

Drug(s) Affected By Programmed cell death protein 5 (PDCD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[202]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[514]

Drug(s) Affected By TPR and ankyrin repeat-containing protein 1 (TRANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]

Drug(s) Affected By E3 ubiquitin-protein ligase Midline-1 (MID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[516]

Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 1 (SIPA1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[518]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Large ribosomal subunit protein bL33m (MRPL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[521]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[522]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[523]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[524]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[525]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[526]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[527]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[528]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[529]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[530]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[530]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[531]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[532]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[533]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[534]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[535]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]

Drug(s) Affected By Transcriptional activator GLI3 (GLI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[538]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By Zinc finger protein 40 (HIVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[541]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Histone H1.5 (H1-5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[542]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[543]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]

Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[544]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[545]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 4 (ATP2B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[450]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[450]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Transcription factor HIVEP2 (HIVEP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[547]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By AF4/FMR2 family member 1 (AFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[431]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[548]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By 2-iminobutanoate/2-iminopropanoate deaminase (RIDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[549]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[550]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Small ribosomal subunit protein eS1 (RPS3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[551]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[552]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[553]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]

Drug(s) Affected By Large ribosomal subunit protein eL43 (RPL37A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[554]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm6 (LSM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[557]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]

Drug(s) Affected By Dynein light chain Tctex-type 1 (DYNLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[558]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[559]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[560]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[561]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Nuclear factor 1 A-type (NFIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL-B (CBLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[345]

Drug(s) Affected By Centromere protein R (ITGB3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[212]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[565]

Drug(s) Affected By Cytochrome c oxidase copper chaperone (COX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[566]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[521]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[521]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[521]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[521]

Drug(s) Affected By Protocadherin Fat 1 (FAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[567]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC1 (HERC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By Nuclear receptor coactivator 1 (NCOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[570]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[571]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]

Drug(s) Affected By Bridge-like lipid transfer protein family member 1 (BLTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]

Drug(s) Affected By Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Cytochrome c oxidase assembly factor 6 homolog (COA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[574]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[575]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[576]

Drug(s) Affected By Testis-expressed protein 30 (TEX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[577]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Protein furry homolog (FRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF213 (RNF213)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By Electron transfer flavoprotein regulatory factor 1 (ETFRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Chondroitin sulfate proteoglycan 4 (CSPG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[578]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[579]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]

Drug(s) Affected By Protocadherin Fat 4 (FAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By Prickle-like protein 2 (PRICKLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[580]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Coiled-coil domain-containing protein 91 (CCDC91)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 1 (SRGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]

Drug(s) Affected By Diacylglycerol kinase eta (DGKH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]

Drug(s) Affected By Sterile alpha motif domain-containing protein 9-like (SAMD9L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[375]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[581]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[582]

Drug(s) Affected By SID1 transmembrane family member 2 (SIDT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[583]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[584]

Drug(s) Affected By Zinc finger protein GLIS3 (GLIS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]

Drug(s) Affected By Histone-lysine N-methyltransferase 2C (KMT2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[225]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[585]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[586]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[587]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Nucleoporin Nup37 (NUP37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 15 (ADAMTS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[539]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[513]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[541]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Nesprin-2 (SYNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By Protein FAM162A (FAM162A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Small ribosomal subunit protein mS37 (CHCHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[588]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[589]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By HAUS augmin-like complex subunit 1 (HAUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Leucine-rich repeat protein 1 (LRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[590]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]

Drug(s) Affected By E3 SUMO-protein ligase NSE2 (NSMCE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Transcriptional-regulating factor 1 (TRERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[591]

Drug(s) Affected By Transcription elongation factor, mitochondrial (TEFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Probable G-protein coupled receptor 21 (GPR21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[592]

Drug(s) Affected By Programmed cell death protein 10 (PDCD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[593]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[594]

Drug(s) Affected By Mitochondrial ornithine transporter 2 (SLC25A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[595]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[595]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[596]

Drug(s) Affected By Transmembrane protein 60 (TMEM60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Inactive tyrosine-protein kinase PEAK1 (PEAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Centrosomal protein 15 (CEP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[521]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]

Drug(s) Affected By Protein TANC2 (TANC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[598]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]

Drug(s) Affected By Ectopic P granules protein 5 homolog (EPG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[556]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[599]

Drug(s) Affected By Protocadherin-18 (PCDH18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[228]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[600]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By Ribosome biogenesis protein SLX9 homolog (SLX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Gypsy retrotransposon integrase-like protein 1 (GIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[84]

Drug(s) Affected By Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[601]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By Coiled-coil domain-containing protein 167 (CCDC167)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[602]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[603]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[604]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[604]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[144]

Drug(s) Affected By Methyl-CpG-binding domain protein 5 (MBD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]

Drug(s) Affected By Malignant T-cell-amplified sequence 1 (MCTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[605]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Ataxin-7-like protein 1 (ATXN7L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[247]

Drug(s) Affected By Anaphase-promoting complex subunit 10 (ANAPC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[606]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[607]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[579]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]

Drug(s) Affected By Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[410]
Ketoprofen	DMRKXPT	Bursitis		Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[608]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[609]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[502]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[610]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[611]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[612]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[613]
Haloperidol	DM96SE0	Delirium		Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[608]
Selenium	DM25CGV	N. A.	N. A.	Approved	[614]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[615]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[616]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[617]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[618]
Selenium	DM25CGV	N. A.	N. A.	Approved	[477]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[619]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[620]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[621]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[622]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[623]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]

Drug(s) Affected By Leucine-rich repeat and death domain-containing protein 1 (LRRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Protein FAM83G (FAM83G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By TRPM8 channel-associated factor 2 (TCAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[624]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[625]

Drug(s) Affected By Photoreceptor cilium actin regulator (PCARE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Serpin-like protein HMSD (HMSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[626]

Drug(s) Affected By ATP-dependent RNA helicase DDX39A (DDX39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[627]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[628]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[629]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[631]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[632]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit F (EIF3F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[633]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[634]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[635]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[632]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[636]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[637]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[638]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[640]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[641]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[642]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]

Drug(s) Affected By Proteasome subunit alpha type-7 (PSMA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[643]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]

Drug(s) Affected By PDZ domain-containing protein 2 (PDZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[644]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[644]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[645]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[644]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[646]

Drug(s) Affected By Toll-like receptor 3 (TLR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[647]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[649]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[650]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[650]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[651]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[649]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[650]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[652]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[649]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[653]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[649]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[654]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[656]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[657]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[658]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[659]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]

Drug(s) Affected By Ras-related protein Rab-3D (RAB3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[91]

Drug(s) Affected By Synaptosomal-associated protein 29 (SNAP29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[589]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[660]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[661]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[542]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[662]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[663]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[632]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Glutamate dehydrogenase 1, mitochondrial (GLUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[665]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[665]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[666]
Haloperidol	DM96SE0	Delirium		Approved	[338]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[667]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[668]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[669]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[620]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[670]

Drug(s) Affected By Aspartate aminotransferase, mitochondrial (GOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[671]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[672]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[338]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[588]

Drug(s) Affected By Proto-oncogene serine/threonine-protein kinase mos (MOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[674]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[675]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[676]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[677]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[679]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[679]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[680]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[681]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[682]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[683]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[680]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[685]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[686]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[687]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[257]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[688]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[689]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[690]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[691]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[692]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[693]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[694]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[695]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[696]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[697]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[153]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[153]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[153]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[153]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[153]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[698]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[532]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[699]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[700]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[701]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[676]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[701]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[702]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[677]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[703]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[217]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[308]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[704]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[705]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[680]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[706]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[707]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[708]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[709]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[710]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[711]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[712]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[713]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[714]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[715]

Drug(s) Affected By Metallothionein-1A (MT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[362]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[716]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[717]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[557]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[716]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[716]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[693]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[535]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[694]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[718]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[719]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[720]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[721]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[722]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[723]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[724]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[725]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[726]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[727]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[333]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[488]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[476]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[728]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[729]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[730]
Fructose	DM43AN2	Vomiting	MD90	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[731]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[732]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[288]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[733]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[734]

Drug(s) Affected By Protein S100-A6 (S100A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[735]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[736]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Phosphoglycerate kinase 2 (PGK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[158]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[737]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[738]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[683]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[739]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[740]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[676]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Metallothionein-1B (MT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[741]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[598]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[742]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[743]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[744]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[518]

Drug(s) Affected By Profilin-1 (PFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[745]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[318]
Haloperidol	DM96SE0	Delirium		Approved	[211]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial (PDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[746]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[747]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[748]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[455]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[749]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[577]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[318]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[750]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[745]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[194]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[751]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[333]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[752]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[618]
Selenium	DM25CGV	N. A.	N. A.	Approved	[753]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[491]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[754]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[567]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[755]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[677]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[756]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[757]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[660]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[758]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[301]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[758]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[759]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[760]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[761]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[762]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[763]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[764]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[438]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[765]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By POTE ankyrin domain family member I (POTEI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[766]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase A-like 4G (PPIAL4G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[767]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[768]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[769]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[333]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[732]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[474]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[770]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[153]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[771]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[772]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[375]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]

Drug(s) Affected By Histone H1.4 (H1-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[543]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[773]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[312]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[774]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[775]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[776]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[314]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[777]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[778]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[779]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[569]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[780]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[781]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[782]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[783]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[94]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[784]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[223]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[785]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[786]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[785]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[785]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[785]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[787]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[788]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[789]
Selenium	DM25CGV	N. A.	N. A.	Approved	[686]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[790]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[791]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[792]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]

Drug(s) Affected By Polyadenylate-binding protein 1 (PABPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[793]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[794]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[795]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[796]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[797]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[798]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]

Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]

Drug(s) Affected By Ribonuclease inhibitor (RNH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[741]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[800]

Drug(s) Affected By Plastin-3 (PLS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Haloperidol	DM96SE0	Delirium		Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[228]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[468]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By Glucosidase 2 subunit beta (PRKCSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[552]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[558]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[801]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[802]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[803]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 2 (RAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[804]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Bortezomib	DMNO38U	Leukemia		Approved	[232]

Drug(s) Affected By Small ribosomal subunit protein uS5 (RPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[805]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[806]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[805]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[807]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[808]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[577]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[632]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[809]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[810]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[811]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[812]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[813]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[737]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[814]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]

Drug(s) Affected By High mobility group protein HMG-I/HMG-Y (HMGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[815]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Methamphetamine	DMPM4SK	Anxiety		Approved	[816]

Drug(s) Affected By Calpain-2 catalytic subunit (CAPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[817]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[818]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[819]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[818]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]

Drug(s) Affected By Large ribosomal subunit protein uL30 (RPL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[821]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]

Drug(s) Affected By Large ribosomal subunit protein uL22 (RPL17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By Ras-related protein Rab-6A (RAB6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[822]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[585]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[430]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[823]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[824]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[825]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]

Drug(s) Affected By Filamin-A (FLNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[826]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[827]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[828]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[787]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Bortezomib	DMNO38U	Leukemia		Approved	[232]

Drug(s) Affected By Histone H1t (H1-6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[829]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]

Drug(s) Affected By Adenosylhomocysteinase (AHCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[305]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[830]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[831]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[832]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[833]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[779]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[834]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[523]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[835]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[687]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[836]

Drug(s) Affected By Proteasome subunit alpha type-2 (PSMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[746]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Proteasome subunit alpha type-4 (PSMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[837]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[521]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[643]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[838]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[839]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[840]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[841]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[842]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[843]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[844]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[845]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[846]

Drug(s) Affected By Large ribosomal subunit protein eL13 (RPL13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[829]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[803]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[847]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[848]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[849]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[778]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[850]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[851]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[852]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[853]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[854]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[855]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[856]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[848]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[857]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[858]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[859]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[847]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[778]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[850]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[860]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[374]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[861]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[862]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[863]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[675]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]

Drug(s) Affected By Adenylosuccinate synthetase isozyme 2 (ADSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[864]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[703]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[865]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[866]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[867]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[713]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[779]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[868]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[869]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[870]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[535]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[687]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[871]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[407]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[872]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[750]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[873]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[874]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[875]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[876]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[877]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[878]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[879]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[880]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[880]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[881]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[817]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[882]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[731]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[883]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[884]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[885]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[886]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[887]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[888]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[889]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[890]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[751]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[891]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[892]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[893]
Haloperidol	DM96SE0	Delirium		Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[894]

Drug(s) Affected By Large ribosomal subunit protein uL4 (RPL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[895]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[803]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[896]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[897]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[898]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]

Drug(s) Affected By RNA-binding motif protein, X chromosome (RBMX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[899]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[834]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[900]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[901]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[902]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By T-complex protein 1 subunit zeta (CCT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[903]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[763]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[552]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[904]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[905]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[906]

Drug(s) Affected By Malate dehydrogenase, cytoplasmic (MDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[567]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]

Drug(s) Affected By Malate dehydrogenase, mitochondrial (MDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[907]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[672]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[908]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[909]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[824]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[910]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[911]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[912]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[913]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[710]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[914]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[915]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[916]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[917]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[918]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[313]

Drug(s) Affected By Small ribosomal subunit protein eS27 (RPS27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Haloperidol	DM96SE0	Delirium		Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[919]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[550]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[300]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[792]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[920]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[708]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[921]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[922]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[923]

Drug(s) Affected By 26S proteasome regulatory subunit 6B (PSMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[924]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[925]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[731]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[926]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[618]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[733]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[927]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[928]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[733]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[929]

Drug(s) Affected By Large ribosomal subunit protein uL15 (RPL27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[828]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[828]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[143]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[605]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]

Drug(s) Affected By Large ribosomal subunit protein eL29 (RPL29)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[205]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[930]

Drug(s) Affected By Coatomer subunit delta (ARCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[931]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[932]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[803]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[933]

Drug(s) Affected By Proteasome subunit beta type-3 (PSMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[573]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[643]

Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[934]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[935]
Methamphetamine	DMPM4SK	Anxiety		Approved	[936]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[937]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[935]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[738]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Adaphostin	DM16QSG	Chronic myelogenous leukaemia	2A20.0	Phase 1	[938]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[817]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[255]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[939]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[940]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[941]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[942]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[943]

Drug(s) Affected By T-complex protein 1 subunit theta (CCT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[944]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[945]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Annexin A11 (ANXA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[521]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[553]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]

Drug(s) Affected By Ras-related protein Rab-5C (RAB5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[946]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[947]

Drug(s) Affected By Cytoplasmic tyrosine-protein kinase BMX (BMX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[948]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[949]

Drug(s) Affected By Tyrosine-protein kinase JAK3 (JAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[950]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[951]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[552]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[950]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[952]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein F (HNRNPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[676]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[946]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[953]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[954]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[955]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[956]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[716]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[955]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[396]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[955]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[957]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[537]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]

Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[958]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[959]

Drug(s) Affected By Exportin-2 (CSE1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[960]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[578]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[231]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[961]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[962]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[777]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[963]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[660]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[964]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[965]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[966]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit B (EIF3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[745]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[233]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[967]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Epiplakin (EPPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[968]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]

Drug(s) Affected By Ras-related protein Rab-15 (RAB15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[969]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[970]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[954]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[713]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[971]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[841]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[972]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[973]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[974]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[807]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[975]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[976]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[565]
Bortezomib	DMNO38U	Leukemia		Approved	[232]

Drug(s) Affected By Large ribosomal subunit protein eL15 (RPL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[977]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[450]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[978]

Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[701]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[979]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[980]

Drug(s) Affected By Small ribosomal subunit protein uS15 (RPS13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[578]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[217]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[576]

Drug(s) Affected By Small nuclear ribonucleoprotein Sm D3 (SNRPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[981]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Large ribosomal subunit protein eL8 (RPL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[982]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[983]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[982]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[984]

Drug(s) Affected By Small ribosomal subunit protein eS4, X isoform (RPS4X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[676]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[985]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[594]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Large ribosomal subunit protein uL23 (RPL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[521]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[986]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[945]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[987]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]

Drug(s) Affected By GTP-binding nuclear protein Ran (RAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[750]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[606]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[988]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[518]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Small ribosomal subunit protein eS28 (RPS28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[578]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[989]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[990]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (FAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[985]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[594]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Large ribosomal subunit protein uL1 (RPL10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[991]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[992]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[991]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]

Drug(s) Affected By Hemoglobin subunit alpha (HBA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[567]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[993]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[994]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[995]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[996]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[800]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[997]

Drug(s) Affected By Large ribosomal subunit protein eL42 (RPL36A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[73]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[838]

Drug(s) Affected By Large ribosomal subunit protein eL19 (RPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[211]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[998]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[594]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[838]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[250]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[999]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[756]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1000]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1001]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1002]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1003]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[789]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[715]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[255]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1004]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[60]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[374]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[1005]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1006]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1007]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1007]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1008]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1007]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]

Drug(s) Affected By Interferon-induced transmembrane protein 3 (IFITM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1009]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[550]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[86]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1010]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[955]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[956]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[955]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[955]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[562]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[1011]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[485]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[955]

Drug(s) Affected By Cytoskeleton-associated protein 4 (CKAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[673]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[778]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1012]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1013]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1014]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1015]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1016]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1016]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1017]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1018]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1016]

Drug(s) Affected By Ras-GEF domain-containing family member 1B (RASGEF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1019]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[596]

Drug(s) Affected By Interleukin enhancer-binding factor 2 (ILF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1020]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1020]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[330]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[59]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1021]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1022]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Haloperidol	DM96SE0	Delirium		Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[817]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[571]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1023]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1008]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[169]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1024]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[828]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1025]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[678]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1026]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1027]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1028]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1029]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1030]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1031]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1032]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1033]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1034]

Drug(s) Affected By Fibroblast growth factor-binding protein 1 (FGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[518]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[468]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[438]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Next to BRCA1 gene 1 protein (NBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[547]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]

Drug(s) Affected By Plastin-1 (PLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1035]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]

Drug(s) Affected By Neutral alpha-glucosidase AB (GANAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Bortezomib	DMNO38U	Leukemia		Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]

Drug(s) Affected By Importin subunit beta-1 (KPNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[309]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1036]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1036]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]

Drug(s) Affected By Plectin (PLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[745]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[750]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 2 (NR0B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1037]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[785]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[100]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[828]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[502]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[785]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1038]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1039]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[785]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[583]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1040]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[1040]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[952]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[1041]

Drug(s) Affected By Ecto-NOX disulfide-thiol exchanger 2 (ENOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1042]
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[1043]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[924]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[752]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[1044]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1045]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[619]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1046]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1047]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[924]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[618]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1048]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[610]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[1049]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[929]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1050]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1051]

Drug(s) Affected By Survival motor neuron protein (SMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[1052]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1052]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[1052]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1053]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1054]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1055]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1056]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1056]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1057]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1058]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1059]

Drug(s) Affected By Lanosterol 14-alpha demethylase (CYP51A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[1060]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[1060]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1-like 2 (HNRNPA1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[335]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[1061]

Drug(s) Affected By Cell adhesion molecule-related/down-regulated by oncogenes (CDON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1062]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[91]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]

Drug(s) Affected By CREB-regulated transcription coactivator 2 (CRTC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[1063]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[1064]

Drug(s) Affected By Beta-actin-like protein 2 (ACTBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[211]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[766]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[441]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[588]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[540]

Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[89]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]

Drug(s) Affected By UMP-CMP kinase 2, mitochondrial (CMPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1065]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]

Drug(s) Affected By RNA-binding protein 48 (RBM48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By Protein odr-4 homolog (ODR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[1066]

Drug(s) Affected By Protein GPR107 (GPR107)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[1067]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]

Drug(s) Affected By Little elongation complex subunit 2 (ICE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1019]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1068]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By POTE ankyrin domain family member E (POTEE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1069]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]

Drug(s) Affected By HHIP-like protein 2 (HHIPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]

Drug(s) Affected By MEF2-activating motif and SAP domain-containing transcriptional regulator (MAMSTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By RNA-binding protein with multiple splicing 2 (RBPMS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD9 (KCTD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[473]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[576]

Drug(s) Affected By Keratin, type II cytoskeletal 1b (KRT77)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[1070]

Drug(s) Affected By Centriolin (CNTRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1071]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[235]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[589]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[91]

Drug(s) Affected By Cullin-associated NEDD8-dissociated protein 1 (CAND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[68]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[589]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By Glucocorticoid-induced transcript 1 protein (GLCCI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Osteopetrosis-associated transmembrane protein 1 (OSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[1072]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1073]

Drug(s) Affected By Ral GTPase-activating protein subunit beta (RALGAPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[515]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By HEAT repeat-containing protein 5A (HEATR5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[803]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By MAP kinase-activated protein kinase 5 (MAPKAPK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[521]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[521]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1074]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID26560530-Compound-35	DMO36RL	N. A.	N. A.	Patented	[1075]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX60 (DDX60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[703]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[737]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[96]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[558]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By T-complex protein 11-like protein 2 (TCP11L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[83]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1076]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1077]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[564]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[430]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[374]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[139]
Bortezomib	DMNO38U	Leukemia		Approved	[232]

Drug(s) Affected By CREB-binding protein (CREBBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1078]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[368]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1079]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[375]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[194]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[671]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[703]

Drug(s) Affected By Histone H2B type 1-A (H2BC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]

Drug(s) Affected By THO complex subunit 1 (THOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[865]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[558]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]

Drug(s) Affected By Fatty acid hydroxylase domain-containing protein 2 (FAXDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[205]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]

Drug(s) Affected By Protein maelstrom homolog (MAEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[861]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By Fc receptor-like protein 3 (FCRL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[163]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[828]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[416]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1080]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1081]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[416]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[1080]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1082]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 14 (MAP3K14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1083]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]

Drug(s) Affected By A-kinase anchor protein 9 (AKAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[1084]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1085]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Myb-binding protein 1A (MYBBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[211]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By Phagosome assembly factor 1 (PHAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[599]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1086]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[82]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1087]

Drug(s) Affected By RNA polymerase II-associated protein 1 (RPAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[572]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Poly(A) polymerase gamma (PAPOLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[947]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By Cyclin-dependent kinase 19 (CDK19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[368]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[202]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[598]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[139]

Drug(s) Affected By Protein sprouty homolog 4 (SPRY4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[828]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[578]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1088]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1028]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1089]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[219]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1090]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1091]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1092]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1093]

Drug(s) Affected By Ras-related protein Rab-33B (RAB33B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[78]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[519]

Drug(s) Affected By THAP domain-containing protein 2 (THAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[1084]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[370]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[80]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1087]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[703]

Drug(s) Affected By Acyl-CoA synthetase short-chain family member 3, mitochondrial (ACSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[196]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]

Drug(s) Affected By Acetyl-coenzyme A synthetase, cytoplasmic (ACSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium Acetate Anhydrous	DMH21E0	Hyponatraemia	5C72	Approved	[1094]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[450]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[450]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[924]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[660]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[804]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1095]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1096]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]

Drug(s) Affected By Suppressor of tumorigenicity 7 protein (ST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[521]

Drug(s) Affected By Pre-mRNA-splicing factor CWC25 homolog (CWC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[427]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[9]

Drug(s) Affected By Myoferlin (MYOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1097]

Drug(s) Affected By EH domain-containing protein 2 (EHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[521]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[91]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[56]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[842]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1098]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[846]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[586]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[56]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1099]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[655]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]

Drug(s) Affected By Signal-transducing adaptor protein 2 (STAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[141]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[224]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[335]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[79]

Drug(s) Affected By ATPase family AAA domain-containing protein 2B (ATAD2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[144]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[208]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[71]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[555]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[242]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[80]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[244]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1102]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[520]

Drug(s) Affected By Large ribosomal subunit protein eL36 (RPL36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1103]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[908]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[111]

Drug(s) Affected By DNA (DNMT3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[840]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[842]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1098]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[846]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[586]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1105]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 3 (OAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[65]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[139]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid synthase (FASN)	TT7AOUD	FAS_HUMAN	Inhibitor	[2]
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Inhibitor	[3]
Matrix metalloproteinase-14 (MMP-14)	TTJ4QE7	MMP14_HUMAN	Inhibitor	[4]
Matrix metalloproteinase-2 (MMP-2)	TTLM12X	MMP2_HUMAN	Inhibitor	[4]
Neutrophil elastase (NE)	TTPLTSQ	ELNE_HUMAN	Inhibitor	[5]
Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ)	TTHPFTS	Q965D7_PLAFA	Inhibitor	[2]
Plasmodium Enoyl-ACP reductase (Malaria fabI)	TTNX2CS	Q965D5_PLAFA	Inhibitor	[6]
Plasmodium Oxoacyl-[acyl-carrier protein] reductase (Malaria fabG)	TTBE4IR	Q965D6_PLAFA	Inhibitor	[2]
Squalene monooxygenase (SQLE)	TTE14XG	ERG1_HUMAN	Inhibitor	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (PLCE1)	OTJISZOX	PLCE1_HUMAN	Gene/Protein Processing	[8]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Gene/Protein Processing	[9]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[10]
2'-5'-oligoadenylate synthase 3 (OAS3)	OT6E5FYS	OAS3_HUMAN	Gene/Protein Processing	[10]
2-iminobutanoate/2-iminopropanoate deaminase (RIDA)	OTW4098I	RIDA_HUMAN	Gene/Protein Processing	[8]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Gene/Protein Processing	[9]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[10]
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Gene/Protein Processing	[11]
5,6-dihydroxyindole-2-carboxylic acid oxidase	OTRK49R4	TYRP1_HUMAN	Gene/Protein Processing	[11]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Gene/Protein Processing	[10]

References

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