Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMQPH29)

• Drug Name: Curcumin Drug Info
• Synonyms: curcumin; 458-37-7; Diferuloylmethane; Natural yellow 3; Turmeric yellow; Turmeric; Curcuma; Kacha haldi; Gelbwurz; Indian saffron; Curcumin I; Souchet; Halud; Halad; Haidr; Haldar; Merita earth; Yellow Ginger; Terra Merita; Yellow Root; Safran d'Inde; Yo-Kin; Golden seal; Curcuma oil; Orange Root; Oils, curcuma; CI Natural Yellow 3; Curcumine; Hydrastis; Indian turmeric; Yellow puccoon; Turmeric extract; Diferaloylmethane; Kurkumin [Czech]; (1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione; Tumeric yellow; Turmeric oil

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 3	[1]

• Cross-matching ID:
  PubChem CID: 969516
  ChEBI ID: CHEBI:3962
  CAS Number: CAS 458-37-7
  TTD Drug ID: DMQPH29
  VARIDT Drug ID: DR00559
  INTEDE Drug ID: DR1941

Molecule-Related Drug Atlas

Drug(s) Targeting Nitric-oxide synthase inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
SD-6010	DM9DEYL	Osteoarthritis	FA00-FA05	Phase 3	[24]
MPL-S	DMNDCFY	Endotoxic shock	1G41	Phase 3	[25]
Pimagedine HCl	DMPWH30	Diabetic kidney disease	GB61.Z	Phase 2/3	[26]
GW274150	DMZMCB1	Asthma	CA23	Phase 2	[27]
BXT-51072	DMD8GNB	Cardiovascular disease	BA00-BE2Z	Phase 2	[28]
HP-228	DMNZ35F	Postoperative pain	MG30-MG3Z	Phase 2	[29]
CR-3294	DMHJEZS	Diarrhea	ME05.1	Phase 2	[30]
KD-7040	DME1WV2	Pain	MG30-MG3Z	Phase 2	[31]
LT-1951	DM5N04G	Coronary artery disease	BA80	Phase 1/2	[32]
Aminoguanidine	DMJQDUC	Diabetic retinopathy	9B71.0	Phase 1	[33]

Drug(s) Targeting Carbonic anhydrase VI (CA-VI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[35]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
SAR566658	DM6Q295	Solid tumour/cancer	2A00-2F9Z	Phase 2	[38]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[36]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[39]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[36]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[40]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Carbonic anhydrase I (CA-I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[41]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[41]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[42]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[41]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
CG-100649	DMIKMA9	Arthritis	FA20	Phase 3	[43]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[44]

Drug(s) Targeting Multidrug resistance protein (MDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzquinamide	DMU4D5Y	Nausea	MD90	Approved	[45]
Ortataxel	DM1EK5D	Solid tumour/cancer	2A00-2F9Z	Phase 2	[46]
MM36	DM6VPIO	Atopic dermatitis	EA80	Phase 2	[8]
Valspodar	DMXRU9M	Acute myeloid leukaemia	2A60	Discontinued in Phase 3	[47]
WK-X-34	DMX0ZBC	Discovery agent	N.A.	Investigative	[8]
KP772	DMUZSJ2	Discovery agent	N.A.	Investigative	[8]
Chemosensitizers	DMYSG9J	Discovery agent	N.A.	Investigative	[48]

Drug(s) Targeting Carbonic anhydrase XII (CA-XII)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[49]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[36]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[36]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[40]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[36]

Drug(s) Targeting Carbonic anhydrase II (CA-II)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[49]
Dorzolamide	DMA17D0	Ocular hypertension	9C61.01	Approved	[50]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[51]
Ethoxzolamide	DMVO4ED	Glaucoma/ocular hypertension	9C61	Approved	[52]
Dichlorphenamide	DMH7IDQ	Chronic glaucoma	9C61.0Z	Approved	[52]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[53]
Ethinamate	DMK57GB	Insomnia	7A00-7A0Z	Approved	[54]
Benzthiazide	DMQWZ0H	High blood pressure	BA00	Approved	[55]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]

Drug(s) Targeting Carbonic anhydrase XIV (CA-XIV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[56]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[39]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[36]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[39]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[36]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[40]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[4]

Drug(s) Targeting Matrix metalloproteinase-13 (MMP-13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Apratastat	DM8W4N9	Rheumatoid arthritis	FA20	Phase 2	[57]
PMID17935984C1	DMO1IHL	Pain	MG30-MG3Z	Clinical trial	[58]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure16(9b)	DMPAQLZ	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure16(9a)	DMKX5R8	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure18(14)	DM7WXJ9	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure16(9c)	DM0ZRI9	N. A.	N. A.	Patented	[59]
GM6001	DM7V9CT	Corneal ulcer	9A76	Discontinued in Phase 2	[60]
RS-130830	DMOTANY	Hepatitis C virus infection	1E51.1	Discontinued in Phase 2	[61]
MMI270	DM38N2K	Discovery agent	N.A.	Investigative	[62]

Drug(s) Targeting Albendazole monooxygenase (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMX-53	DMZUAJ4	Atopic dermatitis	EA80	Phase 2	[63]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[64]
Heme	DMGC287	Discovery agent	N.A.	Investigative	[52]
ML-3163	DM3S5UC	Discovery agent	N.A.	Investigative	[65]
6-(3-Hydroxy-phenyl)-naphthalen-2-ol	DMH8WA2	Discovery agent	N.A.	Investigative	[66]
2-(2-(4-tert-Butylphenylthio)ethyl)-1H-imidazole	DMZVBPG	Discovery agent	N.A.	Investigative	[67]
ML-3375	DMXJY6W	Discovery agent	N.A.	Investigative	[65]
ML-3403	DMTQWI8	Discovery agent	N.A.	Investigative	[65]
4-[5-(3-Hydroxyphenyl)-3-thienyl]-2-methylphenol	DM7ERYJ	Discovery agent	N.A.	Investigative	[68]
2-Fluoro-4-[5-(3-hydroxyphenyl)-2-thienyl]phenol	DMUGAT8	Discovery agent	N.A.	Investigative	[68]

Drug(s) Targeting Xanthine dehydrogenase/oxidase (XDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Allopurinol	DMLPAOB	Gout	FA25	Approved	[69]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[70]
Fosdenopterin	DMR0TYK	Molybdenum cofactor deficiency	5B5K.A	Approved	[71]
Oxypurinol	DMURH4X	Heart failure	BD10-BD13	Phase 2/3	[72]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[73]
Topiroxostat	DMA04DE	Gout	FA25	Phase 2	[74]
TMX-049	DME8PFQ	Diabetic nephropathy	GB61.Z	Phase 2	[75]
LC-350189	DMHT3CB	Gout	FA25	Phase 1	[76]
Azaindole derivative 5	DMD2BL3	N. A.	N. A.	Patented	[77]
Fused heterocyclic compound 3	DM2QVHY	N. A.	N. A.	Patented	[77]

Drug(s) Targeting Carbonic anhydrase (CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[78]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[35]
Quinethazone	DMWCOSR	Hypertension	BA00-BA04	Approved	[79]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[80]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[36]
PMID30074415-Compound-21	DM3NPOU	N. A.	N. A.	Patented	[81]
Imatinib and nilotinib derivative 2	DM34NZ8	Cas mediated disorder	N.A.	Patented	[81]

Drug(s) Targeting Carbonic anhydrase IV (CA-IV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[34]
Sulfamylon	DMIO1K0	Bacterial infection	1A00-1C4Z	Approved	[82]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[41]
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
Sodium pyruvate	DMST6A3	Asthma	CA23	Phase 1/2	[83]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[80]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[36]
SPERMINE	DMD4BFY	N. A.	N. A.	Terminated	[39]

Drug(s) Targeting Matrix metalloproteinase-9 (MMP-9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DP-b99	DM97S10	Stroke	8B20	Phase 3	[84]
GS-5745	DMP8MDW	Gastric adenocarcinoma	2B72	Phase 3	[85]
Andecaliximab	DMLDB1X	Gastric adenocarcinoma	2B72	Phase 3	[86]
BLZ-100	DMFKA4G	Glioma	2A00.0	Phase 1/2	[87]
Neovastat	DMXTYWJ	Non-small-cell lung cancer	2C25.Y	Phase 1	[88]
PMID29130358-Compound-Figure18(14a)	DMHIBTZ	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure17(12)	DMML4PA	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure17(10)	DMVA15O	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-SB-3CT	DMC64XQ	N. A.	N. A.	Patented	[59]
PMID29130358-Compound-Figure17(11)	DMSZA9L	N. A.	N. A.	Patented	[59]

Drug(s) Targeting Prostaglandin G/H synthase 1 (COX-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[89]
Naproxen	DMZ5RGV	Bursitis		Approved	[90]
Mesalazine	DMOL5IU	Diverticulitis		Approved	[91]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[92]
Bromfenac	DMKB79O	Pain	MG30-MG3Z	Approved	[93]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[41]
Flufenamic Acid	DMC8VNH	Dysmenorrhea	GA34.3	Approved	[94]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[41]
Suprofen	DMKXJZ7	Miosis	LA11.62	Approved	[95]
Gamma-Homolinolenic acid	DMSXKYG	Malnutrition	5B50-5B71	Approved	[96]

Drug(s) Targeting Carbonic anhydrase IX (CA-IX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PARABEN	DMEW5Z8	N. A.	N. A.	Phase 3	[36]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[4]
Coumate	DMVKW0N	Breast cancer	2C60-2C65	Phase 2	[37]
INDISULAM	DM9SX6Y	Lymphoma	2A80-2A86	Phase 2	[97]
Girentuximab I-124	DMG3O2Z	Renal cell carcinoma	2C90	Phase 2	[98]
SULFAMIDE	DMMAS3K	N. A.	N. A.	Phase 1	[99]
BAY 79-4620	DM14XQN	Solid tumour/cancer	2A00-2F9Z	Phase 1	[100]
90Y-cG250	DMJR6TC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[101]
FERULIC ACID	DMJC7NF	Discovery agent	N.A.	Patented	[36]
PMID30074415-Compound-GS3	DM2G8DN	N. A.	N. A.	Patented	[81]

Drug(s) Targeting DNA [cytosine-5]-methyltransferase 3B (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27376512-Compound-MTC-424	DMGNRZU	N. A.	N. A.	Patented	[102]
PMID27376512-Compound-MTC-427	DMWXEZD	N. A.	N. A.	Patented	[102]
PMID27376512-Compound-MTC-422	DM1MVQD	N. A.	N. A.	Patented	[102]
PMID27376512-Compound-MTC-423	DM9RSDX	N. A.	N. A.	Patented	[102]
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[103]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[5]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[5]
NSC-138419	DMH684Q	Discovery agent	N.A.	Investigative	[5]
NSC-319745	DMF3G06	Discovery agent	N.A.	Investigative	[5]
NSC-348926	DM3TDEO	Discovery agent	N.A.	Investigative	[5]

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[104]
Naproxen	DMZ5RGV	Bursitis		Approved	[90]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[105]
Indomethacin	DMSC4A7	Bursitis		Approved	[41]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[106]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[107]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[108]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[109]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[92]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[41]

Drug(s) Targeting Amyloid beta A4 protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nirogacestat	DMUP5Z0	Desmoid tumour	2F7C	Approved	[110]
Aducanumab	DM51JW4	Alzheimer disease	8A20	Approved	[111]
Lecanemab	DMW03YD	Alzheimer disease	8A20	Approved	[112]
Florbetapir F-18	DMJ8A3Z	Diagnostic imaging	N.A.	Approved	[113]
GV-971	DMTMA5W	Alzheimer disease	8A20	Approved in China	[114]
Solanezumab	DM0HIU5	Alzheimer disease	8A20	Phase 3	[115]
Tramiprosate	DM7BSRH	Alzheimer disease	8A20	Phase 3	[116]
Bapineuzumab	DMHQ5GK	Alzheimer disease	8A20	Phase 3	[117]
ALZT-OP1	DMG5BTD	Alzheimer disease	8A20	Phase 3	[118]
Gantenerumab	DMWX90U	Alzheimer disease	8A20	Phase 3	[119]

Drug(s) Targeting DNA [cytosine-5]-methyltransferase (DNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[120]
S-110	DMXY34J	Acute myeloid leukaemia	2A60	Phase 3	[121]
ASTX727	DM4HK8Z	Chronic myelogenous leukaemia	2A20.0	Phase 3	[110]
PMID27376512-Compound-PG-11047	DM5K4YF	N. A.	N. A.	Patented	[102]
PMID27376512-Compound-PG-11048	DM3U7RN	N. A.	N. A.	Patented	[102]
PMID27376512-Compound-MTC-434	DM70CTE	N. A.	N. A.	Patented	[102]
PMID27376512-Compound-CROs	DMBFUTL	N. A.	N. A.	Patented	[102]
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[103]
NSC-622445	DME35CB	Discovery agent	N.A.	Investigative	[5]
NSC-622444	DMM5UT9	Discovery agent	N.A.	Investigative	[5]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[122]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[12]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[124]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[12]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[12]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[125]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[12]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[126]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[127]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[129]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[131]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[133]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[134]
Metronidazole	DMTIVEN	Abscess		Approved	[135]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A9 (UGT1A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[138]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[139]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[142]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[141]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[141]
Haloperidol	DM96SE0	Delirium		Approved	[141]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A8 (UGT1A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
Empagliflozin	DMRF9YK	Type-1 diabetes	5A10	Approved	[145]
Darolutamide	DMV7YFT	Prostate cancer	2C82.0	Approved	[146]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[147]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[13]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[13]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[13]
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[13]
Cis-4-hydroxytamoxifen	DMRFTB5	N. A.	N. A.	Investigative	[147]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A7 (UGT1A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[144]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[13]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[13]
phloretin	DMYA50U	Discovery agent	N.A.	Investigative	[13]
Anthraflavic acid	DMN1YFU	N. A.	N. A.	Investigative	[13]

Drug(s) Metabolized By NADPH-dependent curcumin reductase (curA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[14]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[148]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[149]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[150]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[151]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[152]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[153]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[154]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[155]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[156]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[154]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[158]
Fructose	DM43AN2	Vomiting	MD90	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[161]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[172]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[173]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[176]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[178]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[178]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[179]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[184]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[185]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[185]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[185]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[186]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[187]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[188]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[189]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[190]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[191]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[159]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[175]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[192]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[196]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[197]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Fructose	DM43AN2	Vomiting	MD90	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]

Drug(s) Affected By Lymphotoxin-alpha (LTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[212]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[214]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[214]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[220]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[224]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[234]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[239]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[242]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[243]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[249]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[250]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[251]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[252]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[264]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[267]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[272]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[273]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[165]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[274]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[277]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[278]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Fructose	DM43AN2	Vomiting	MD90	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[280]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[281]

Drug(s) Affected By Caspase-4 (CASP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[287]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[291]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[292]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[267]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[296]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[259]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[300]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[301]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[302]

Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[305]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]

Drug(s) Affected By TNF receptor-associated factor 3 (TRAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[311]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[313]

Drug(s) Affected By Septin-7 (SEPTIN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[316]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Secreted frizzled-related protein 5 (SFRP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[318]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[319]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[320]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[333]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[334]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[335]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[336]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[339]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[340]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[341]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[342]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[343]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[347]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[344]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[348]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[349]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[350]

Drug(s) Affected By Farnesyl pyrophosphate synthase (FDPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[353]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[356]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[357]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[358]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[361]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[362]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[363]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[365]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[367]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[368]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[367]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[369]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[370]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[372]

Drug(s) Affected By Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Bortezomib	DMNO38U	Leukemia		Approved	[374]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[377]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[376]

Drug(s) Affected By Period circadian protein homolog 2 (PER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[380]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[382]

Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[335]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[175]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[384]

Drug(s) Affected By Dual specificity protein phosphatase CDC14B (CDC14B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[387]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[384]

Drug(s) Affected By Receptor activity-modifying protein 1 (RAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]

Drug(s) Affected By Anterior gradient protein 2 homolog (AGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[390]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[396]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]

Drug(s) Affected By Neprilysin (MME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[398]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[399]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[400]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]

Drug(s) Affected By Melanotransferrin (MELTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[402]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[386]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[404]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[407]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[406]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[405]

Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[349]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By B-lymphocyte antigen CD20 (MS4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[411]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[415]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[416]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[417]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[418]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[422]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[423]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]

Drug(s) Affected By Nucleoside diphosphate kinase A (NME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]

Drug(s) Affected By Immunoglobulin lambda-like polypeptide 1 (IGLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Bortezomib	DMNO38U	Leukemia		Approved	[374]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[433]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[434]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[435]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[408]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[416]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[439]
Bortezomib	DMNO38U	Leukemia		Approved	[440]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[384]

Drug(s) Affected By Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[318]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[443]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[444]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 7 (PTPN7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[450]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[451]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[452]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[454]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform (PPP3CC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[456]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[408]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]

Drug(s) Affected By Ras association domain-containing protein 2 (RASSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[460]
Indomethacin	DMSC4A7	Bursitis		Approved	[461]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 6 (CLCN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[462]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[463]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Nuclear pore complex protein Nup98-Nup96 (NUP98)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[466]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[332]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[332]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[467]

Drug(s) Affected By Diphosphomevalonate decarboxylase (MVD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[468]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[470]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[471]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[473]

Drug(s) Affected By NPC intracellular cholesterol transporter 2 (NPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[474]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[375]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[476]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[383]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[477]

Drug(s) Affected By Dynein light chain 1, cytoplasmic (DYNLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[478]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[479]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[335]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[480]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[383]

Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[482]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[483]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[480]

Drug(s) Affected By Transcription factor Spi-B (SPIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[485]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[486]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Lymphotoxin-beta (LTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[487]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[257]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[489]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[490]

Drug(s) Affected By Cadherin-17 (CDH17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[491]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[458]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[492]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Inositol 1,4,5-triphosphate receptor associated 2 (IRAG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[493]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[315]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[209]

Drug(s) Affected By Lymphocyte cytosolic protein 2 (LCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Serine/arginine-rich splicing factor 6 (SRSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[497]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Indomethacin	DMSC4A7	Bursitis		Approved	[498]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[499]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[501]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[394]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]

Drug(s) Affected By Heme transporter HRG1 (SLC48A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[502]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[458]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]

Drug(s) Affected By BCL-6 corepressor (BCOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[386]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[466]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Ankyrin repeat domain-containing protein 37 (ANKRD37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]

Drug(s) Affected By TBC1 domain family member 1 (TBC1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[504]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[505]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[506]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Histone H1.10 (H1-10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]

Drug(s) Affected By Secernin-2 (SCRN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[507]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[404]

Drug(s) Affected By Beta-1,3-galactosyltransferase 6 (B3GALT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[458]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 1 (DHRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[508]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[458]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[404]

Drug(s) Affected By Junctional sarcoplasmic reticulum protein 1 (JSRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[509]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[510]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[345]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[511]

Drug(s) Affected By Large ribosomal subunit protein uL1m (MRPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[508]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Leucine-rich repeat neuronal protein 3 (LRRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[232]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[512]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[232]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[232]

Drug(s) Affected By Pancreatic progenitor cell differentiation and proliferation factor (PPDPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[182]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[507]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By tRNA endonuclease ANKZF1 (ANKZF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[514]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[332]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[515]

Drug(s) Affected By Triggering receptor expressed on myeloid cells 1 (TREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[518]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[519]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[434]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[519]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Cytohesin-4 (CYTH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[520]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[514]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[521]

Drug(s) Affected By Kelch-like protein 21 (KLHL21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]

Drug(s) Affected By Cell cycle progression protein 1 (CCPG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[523]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[327]
Bortezomib	DMNO38U	Leukemia		Approved	[523]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Calcium-activated potassium channel subunit beta-2 (KCNMB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[524]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[525]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[525]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[526]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[527]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[528]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[525]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[525]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[525]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[529]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[530]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[531]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[532]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[505]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[533]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[534]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[535]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[536]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[537]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[538]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[539]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[540]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[541]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[542]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[543]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[544]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[545]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[546]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[547]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[548]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[259]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[549]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[550]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[551]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[552]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[553]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[554]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[555]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[556]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[557]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[559]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[560]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[561]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[562]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[563]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[564]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 1 (NAIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Bortezomib	DMNO38U	Leukemia		Approved	[565]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[566]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[567]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[514]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[568]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[569]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[570]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[572]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[573]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[575]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[576]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[577]

Drug(s) Affected By Regulatory factor X-associated protein (RFXAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[578]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[579]

Drug(s) Affected By Myosin regulatory light chain 12B (MYL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[416]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[580]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[581]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[582]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[583]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[584]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[585]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[354]

Drug(s) Affected By Tripartite motif-containing protein 16 (TRIM16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[586]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[586]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[532]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[505]

Drug(s) Affected By TBC1 domain family member 8 (TBC1D8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[587]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[587]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[588]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[589]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[590]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[591]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[538]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[419]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[592]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[252]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[593]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]

Drug(s) Affected By Complement decay-accelerating factor (CD55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[594]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[416]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Selenium	DM25CGV	N. A.	N. A.	Approved	[597]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[393]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[598]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[599]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[600]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[602]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[597]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[603]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[487]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]

Drug(s) Affected By RNA-binding protein FUS (FUS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[416]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[604]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[605]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[606]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[607]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[608]

Drug(s) Affected By Protein farnesyltransferase subunit beta (CHURC1-FNTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[386]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[327]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[609]

Drug(s) Affected By Regulator of G-protein signaling 7 (RGS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[386]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[610]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[611]

Drug(s) Affected By Large ribosomal subunit protein eL31 (RPL31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[612]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[613]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[232]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[550]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[614]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[615]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[616]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[617]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[618]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Bortezomib	DMNO38U	Leukemia		Approved	[374]

Drug(s) Affected By Krueppel-like factor 10 (KLF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[345]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[462]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Serine/arginine-rich splicing factor 5 (SRSF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[620]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[621]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[408]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[408]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[537]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[408]

Drug(s) Affected By RNA-binding protein 39 (RBM39)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[623]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[624]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[466]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[332]

Drug(s) Affected By NHL repeat-containing protein 2 (NHLRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[625]

Drug(s) Affected By Nanos homolog 1 (NANOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[374]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[462]

Drug(s) Affected By Lysophosphatidic acid receptor 1 (LPAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[626]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[627]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[628]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[628]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[628]

Drug(s) Affected By DNA damage-inducible transcript 4-like protein (DDIT4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[629]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[630]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[458]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Constitutive coactivator of peroxisome proliferator-activated receptor gamma (FAM120B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[375]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[515]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[631]

Drug(s) Affected By Keratin-associated protein 2-1 (KRTAP2-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[632]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[635]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[607]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[235]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[636]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[631]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]

Drug(s) Affected By Ankyrin repeat domain-containing protein 50 (ANKRD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[450]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[558]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[558]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[365]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[558]

Drug(s) Affected By Regulating synaptic membrane exocytosis protein 2 (RIMS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[345]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[631]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[638]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[639]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[640]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[641]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[642]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[643]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[644]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[645]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[646]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[538]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[592]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[648]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[558]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[649]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[650]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[651]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[652]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[653]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]

Drug(s) Affected By Indoleamine 2,3-dioxygenase 1 (IDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-Tryptophan	DMIBH7M	Depression	6A70-6A7Z	Approved	[654]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[655]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[656]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[657]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]

Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[658]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[659]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[660]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[661]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[662]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[454]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[663]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[664]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[664]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[393]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[664]
Fructose	DM43AN2	Vomiting	MD90	Approved	[665]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[664]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[592]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[250]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[558]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[558]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[252]
Selenium	DM25CGV	N. A.	N. A.	Approved	[597]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[666]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[667]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[668]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[531]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[669]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[670]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[671]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[672]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[673]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[674]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[675]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[676]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[677]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[678]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[679]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[679]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[680]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[681]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[682]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[683]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[684]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[555]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[685]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[686]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[556]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[687]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[688]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[689]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[690]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[691]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[692]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[693]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[694]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[695]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[549]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[696]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[697]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[698]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[699]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[700]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[701]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[702]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[694]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[703]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[704]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[705]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[693]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[549]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[696]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[159]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[159]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[706]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[707]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[615]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[708]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[709]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[710]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[711]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[712]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[480]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[713]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[714]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[715]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[538]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[716]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[592]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[717]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[424]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[718]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[719]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[720]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[721]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[722]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[723]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[724]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[393]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[593]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[663]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[725]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[726]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[727]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[728]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[663]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[729]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[730]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[731]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PIK3C2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[374]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[733]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[734]

Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[735]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[480]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[736]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]

Drug(s) Affected By Poly polymerase tankyrase-1 (TNKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[628]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[628]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[737]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[738]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[739]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[740]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[741]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[742]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[743]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[744]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[745]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[746]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[747]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[748]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[631]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[749]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[750]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[751]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[752]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[753]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[754]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[755]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[560]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[756]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[757]

Drug(s) Affected By Insulin-like growth factor I (IGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[745]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[758]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[234]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[759]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[590]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[760]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[761]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[762]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[763]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[764]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[765]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[766]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[250]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[767]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[768]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[769]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[770]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[771]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[772]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[773]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[774]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[774]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[775]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[776]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[777]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[778]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[779]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[780]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[781]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[782]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[783]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[784]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[785]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[786]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[788]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[657]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[789]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[636]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[790]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[791]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[792]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[793]
Bortezomib	DMNO38U	Leukemia		Approved	[374]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[794]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[795]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[796]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[797]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[798]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[799]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[800]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[801]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[802]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[803]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[804]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[805]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[785]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[806]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[807]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[560]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[550]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[808]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[809]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[810]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[811]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[812]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[813]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[814]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[815]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[816]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[817]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[818]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[819]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[820]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[821]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[822]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[823]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[823]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[824]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[825]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[826]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[827]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[828]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[829]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[830]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[831]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[811]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[832]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[833]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[834]

Drug(s) Affected By Cyclin-dependent kinase 7 (CDK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[651]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[835]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[836]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[837]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]

Drug(s) Affected By Cyclin-dependent kinase 9 (CDK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[838]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[733]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[839]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]

Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[840]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]

Drug(s) Affected By Histone deacetylase 4 (HDAC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[841]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[842]
Bortezomib	DMNO38U	Leukemia		Approved	[440]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[843]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[844]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[845]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[846]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[847]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[848]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[849]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[850]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[847]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[851]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[852]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[853]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[854]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[855]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[856]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[857]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[651]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[312]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[563]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[563]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[858]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[859]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[751]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[860]

Drug(s) Affected By Protein kinase C epsilon type (PRKCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[616]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Indomethacin	DMSC4A7	Bursitis		Approved	[861]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[524]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[779]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[862]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[863]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[864]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[865]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[866]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]

Drug(s) Affected By Interferon regulatory factor 5 (IRF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[733]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[867]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[868]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[869]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[870]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[871]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[871]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[872]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[873]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[349]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[874]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[727]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[875]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[865]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[876]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[877]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[878]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]

Drug(s) Affected By Histone deacetylase 11 (HDAC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[456]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[879]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[880]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]

Drug(s) Affected By Histone deacetylase 8 (HDAC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[881]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[882]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]

Drug(s) Affected By Serine/threonine-protein kinase PLK2 (PLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[883]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]

Drug(s) Affected By Histone deacetylase 6 (HDAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[884]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[733]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[885]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[886]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[624]
Bortezomib	DMNO38U	Leukemia		Approved	[887]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[888]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[889]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[890]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[624]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[493]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[383]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[891]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[892]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[893]
Selenium	DM25CGV	N. A.	N. A.	Approved	[894]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[895]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[896]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[897]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[898]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[899]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[900]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[901]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[900]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[902]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[903]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[904]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[828]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[905]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[906]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[907]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[908]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[909]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By Glutathione S-transferase A4 (GSTA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[497]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[910]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]

Drug(s) Affected By Histone deacetylase 3 (HDAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[911]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[912]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[886]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[913]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[914]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[914]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[914]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[914]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[914]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[914]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[914]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[914]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[915]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[805]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[916]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[564]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[543]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[281]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[917]

Drug(s) Affected By 3-phosphoinositide-dependent protein kinase 1 (PDPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[918]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[919]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[920]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[732]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[921]

Drug(s) Affected By Prominin-1 (PROM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[922]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[923]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[924]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[611]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[925]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[926]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[927]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[928]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[650]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[572]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[929]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[930]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[922]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[746]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]

Drug(s) Affected By Glucose-6-phosphate exchanger SLC37A4 (SLC37A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[345]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[931]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By EGF-like repeat and discoidin I-like domain-containing protein 3 (EDIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[628]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[932]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[448]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Adenylate cyclase type 9 (ADCY9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Clotrimazole	DMMFCIH	Cutaneous candidiasis	1F23.14	Approved	[933]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[933]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[934]

Drug(s) Affected By DNA polymerase zeta catalytic subunit (REV3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[384]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[732]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[935]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[937]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[938]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[936]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[939]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[940]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[493]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[941]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[942]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[943]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[944]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[899]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[311]

Drug(s) Affected By L-lactate dehydrogenase A chain (LDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[159]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[945]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[855]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[600]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[922]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[946]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[947]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[948]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[949]
Haloperidol	DM96SE0	Delirium		Approved	[159]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[950]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[951]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[952]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[953]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[954]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[955]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[240]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[956]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[957]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[958]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[959]
Selenium	DM25CGV	N. A.	N. A.	Approved	[743]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[959]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[960]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[956]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[961]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[962]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[963]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[893]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[811]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[928]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[964]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[965]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[966]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[967]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[847]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[968]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[969]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[970]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[955]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[850]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[971]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[972]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[828]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[973]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[974]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[422]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[975]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[976]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[977]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[978]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[979]
Fructose	DM43AN2	Vomiting	MD90	Approved	[159]
Ketoprofen	DMRKXPT	Bursitis		Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[980]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[549]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[981]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[982]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[983]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[984]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[985]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[986]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[987]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[988]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[989]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[990]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[991]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[877]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[992]
Indomethacin	DMSC4A7	Bursitis		Approved	[461]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[461]

Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[993]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[994]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[995]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[996]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[997]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[998]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[999]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1000]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1001]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1002]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[1003]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[1004]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1005]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1006]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[1007]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1008]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1009]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1010]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1011]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[740]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[1012]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1013]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1014]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[1011]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[511]

Drug(s) Affected By Fructose-bisphosphate aldolase A (ALDOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1015]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1016]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[841]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[844]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1017]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1018]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[592]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1019]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[864]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1020]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[1021]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1022]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1023]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1024]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1025]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[635]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1026]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Fructose	DM43AN2	Vomiting	MD90	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[1027]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1028]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[1029]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1030]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1031]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[928]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1032]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1033]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1034]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[801]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[614]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]

Drug(s) Affected By Alpha-enolase (ENO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1035]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1015]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1016]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1036]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[364]

Drug(s) Affected By DNA polymerase beta (POLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[863]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[1037]
Colistin	DMMD9QE	Pseudomonas infection	1B92	Approved	[159]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[181]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[633]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[1038]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[1039]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1040]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1041]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1042]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[971]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1043]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1044]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]

Drug(s) Affected By Decorin (DCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1045]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1046]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1047]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[1048]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[926]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1049]

Drug(s) Affected By Transcription factor Sp1 (SP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1050]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1051]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[997]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[1052]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1053]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1050]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1054]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[1055]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1056]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1057]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1058]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1058]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[1059]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1060]
Selenium	DM25CGV	N. A.	N. A.	Approved	[743]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1061]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1062]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1063]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1064]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[956]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[961]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1065]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[159]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[159]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[159]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[159]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1066]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1067]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1068]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[1069]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[841]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1070]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1071]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[514]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[1072]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1073]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[1074]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1075]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1076]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1077]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[1078]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[1079]

Drug(s) Affected By Homeobox protein Hox-B5 (HOXB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1080]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1081]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[1082]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[450]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[1083]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1084]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[330]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Haloperidol	DM96SE0	Delirium		Approved	[408]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1085]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[482]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[1086]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[250]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1087]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[1087]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[1087]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1088]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[1089]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1090]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[1091]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[1092]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1040]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[1093]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1094]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[1095]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[1096]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1097]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[1098]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[1099]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[186]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[679]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[1100]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[1101]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[788]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1102]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1103]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1105]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1106]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1107]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[1108]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[1110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[1111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1112]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1113]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[359]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[1115]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1117]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[930]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1119]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[1012]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[1027]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[692]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[509]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[1123]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[968]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[968]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[1124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[1125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1126]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[1127]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[1128]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[1125]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[1129]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[1129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1130]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1131]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[1131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[1132]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[1133]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1135]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[801]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[218]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[880]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[289]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Selenium	DM25CGV	N. A.	N. A.	Approved	[743]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[1136]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[775]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[805]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1138]

Drug(s) Affected By Protein C-ets-2 (ETS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[899]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[339]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[578]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[635]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[651]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[743]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[998]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[956]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[841]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[1141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1142]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[922]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[923]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[573]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1144]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1145]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[1146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[637]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1148]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1149]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[864]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[653]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1152]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[361]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1153]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1154]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[923]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[994]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1155]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[1156]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[256]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[287]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[1157]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1158]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[1159]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[1160]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[1161]

Drug(s) Affected By Prolactin receptor (PRLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1162]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[386]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1067]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1165]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[1167]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[1168]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1169]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[1170]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[1171]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[658]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1174]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Haloperidol	DM96SE0	Delirium		Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[584]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[585]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[635]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[790]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[584]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1178]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[635]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[354]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1179]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[834]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[844]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[852]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1180]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1182]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[374]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[715]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[415]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[952]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[615]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]

Drug(s) Affected By Kallikrein-2 (KLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[1185]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[506]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[1186]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1187]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[844]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[801]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1032]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[1074]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[1189]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1190]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[829]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[830]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[809]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[928]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1191]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[874]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[918]

Drug(s) Affected By Nuclear transcription factor Y subunit alpha (NFYA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[1193]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1194]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[1195]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1196]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[550]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1009]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[738]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1197]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[811]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1198]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[802]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[220]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1032]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1202]

Drug(s) Affected By C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1203]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1204]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[1205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1207]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[1208]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[182]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[519]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[1209]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[492]

Drug(s) Affected By C-X-C chemokine receptor type 2 (CXCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1204]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[1210]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1211]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1212]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[1208]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1213]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[793]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[159]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[570]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[592]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[900]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1214]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[905]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[616]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1215]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1217]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[1218]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1221]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1223]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[470]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[741]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[514]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1225]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[651]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[607]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[573]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[235]

Drug(s) Affected By Collagen alpha-5(IV) chain (COL4A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1080]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[877]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1227]

Drug(s) Affected By Protein disulfide-isomerase A3 (PDIA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[915]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[457]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[408]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[408]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[738]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[651]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[415]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1233]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[788]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[767]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1064]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1235]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1236]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1238]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1239]

Drug(s) Affected By Prohibitin 1 (PHB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1240]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[415]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1240]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[1241]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[194]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[655]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1243]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1244]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1246]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1247]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1248]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1250]
Haloperidol	DM96SE0	Delirium		Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[408]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[1251]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[1253]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1254]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[843]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[554]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1256]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1258]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1260]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1261]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[1262]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1263]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[538]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1264]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Signal transducer and activator of transcription 5A (STAT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1265]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[1267]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[1268]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1270]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1271]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[753]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1272]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1274]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[1275]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1276]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[570]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[173]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[786]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1277]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[751]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1278]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1279]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1280]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1283]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[293]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[1285]
Indomethacin	DMSC4A7	Bursitis		Approved	[1286]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1287]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1030]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[738]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1281]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1288]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[740]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1289]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1291]

Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1293]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1295]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1296]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[1297]

Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[1298]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[1299]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[1300]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[631]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[1302]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[1303]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[792]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1304]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[636]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[578]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[1305]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[405]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[405]

Drug(s) Affected By Tuberin (TSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[787]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1306]
Methamphetamine	DMPM4SK	Anxiety		Approved	[1307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[919]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1308]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[788]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1031]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1309]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1310]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[856]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[585]

Drug(s) Affected By Matrix metalloproteinase-14 (MMP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[743]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[956]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1312]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[877]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[1193]
Cysteamine	DMSYFM8	Nephropathic cystinosis	5C60	Approved	[1313]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[194]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1314]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1315]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[805]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[231]

Drug(s) Affected By Methyl-CpG-binding protein 2 (MECP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[912]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[1316]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1317]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1318]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[507]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1319]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1320]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1265]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[841]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[1267]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[1268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1321]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1322]

Drug(s) Affected By Tyrosine-protein kinase JAK3 (JAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1323]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[232]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[374]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[482]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[312]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1323]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[1324]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1325]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1326]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[1327]

Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1328]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1330]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1331]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[232]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[1330]

Drug(s) Affected By Cadherin-11 (CDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[877]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[482]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[994]

Drug(s) Affected By Beta-secretase 1 (BACE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[788]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1335]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]

Drug(s) Affected By Ras-related protein Rab-8A (RAB8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1336]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[480]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1337]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1338]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1339]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1340]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1341]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1342]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[806]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[1343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1344]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1345]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[772]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1102]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1346]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1347]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[783]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[757]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1031]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1032]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[922]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1349]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[573]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1350]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[909]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1351]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[937]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[423]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1352]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[423]

Drug(s) Affected By Transcription factor Sp4 (SP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1050]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1050]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[1353]

Drug(s) Affected By Transcription factor Sp3 (SP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1050]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1050]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[1055]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1354]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[1355]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[1356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1357]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[538]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[423]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1277]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1360]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1361]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1362]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[360]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[955]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1365]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[854]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 1 (EIF4G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1366]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[496]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[878]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]

Drug(s) Affected By Lactoylglutathione lyase (GLO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1016]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Proto-oncogene c-Rel (REL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[1368]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1369]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1370]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[1371]

Drug(s) Affected By Macrophage-stimulating protein receptor (MST1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[404]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
Pyrrolidine dithiocarbamate	DM5ZAS6	Discovery agent	N.A.	Investigative	[1373]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[896]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[746]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[393]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1374]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[1375]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1376]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1377]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1378]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1379]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[544]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[570]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[548]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[469]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[297]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[221]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[174]

Drug(s) Affected By Testican-1 (SPOCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[506]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[461]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[504]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1354]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1295]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[889]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Forkhead box protein O1 (FOXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[809]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1366]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[1383]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[1384]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1385]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[1386]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[1386]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[1387]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1388]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1389]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[1390]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[1386]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[427]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1392]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[1392]

Drug(s) Affected By Forkhead box protein F2 (FOXF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[1156]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[628]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[628]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[1156]

Drug(s) Affected By A-kinase anchor protein 6 (AKAP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[387]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1393]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[339]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[829]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1394]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1395]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1396]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1397]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1398]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1399]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1400]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1401]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[1402]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[820]

Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1403]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[340]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1404]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[1405]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[650]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1406]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[569]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[570]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1406]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[575]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[828]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[829]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1407]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[937]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1056]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[255]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1408]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[811]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[786]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[571]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1409]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1341]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[402]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[346]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1147]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[451]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[601]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1240]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1412]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1077]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[383]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1415]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1416]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[1417]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[968]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1418]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[968]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1419]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[258]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[364]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[623]

Drug(s) Affected By Growth arrest-specific protein 6 (GAS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[398]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[1421]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1422]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[1420]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[1423]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[624]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1424]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[1420]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1425]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[831]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1426]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1427]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1428]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1429]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1430]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1342]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1432]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1433]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1434]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[301]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]

Drug(s) Affected By Polycomb protein SUZ12 (SUZ12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[611]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1435]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[182]

Drug(s) Affected By Periostin (POSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[994]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1436]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1436]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[468]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase R (PTPRR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[377]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[434]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Transcription factor E2F5 (E2F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[735]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[926]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1001]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[1437]

Drug(s) Affected By ETS-related transcription factor Elf-2 (ELF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[732]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[732]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[506]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1438]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[466]

Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[850]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[854]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[716]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[1439]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[722]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[723]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1440]

Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[596]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1441]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[603]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[855]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[249]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[405]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[384]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1442]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1443]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1444]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[1445]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1446]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1447]

Drug(s) Affected By Survival motor neuron protein (SMN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[1448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1448]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[482]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Tobramycin	DMUI0CH	Bacteremia	1A73	Approved	[1448]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[567]

Drug(s) Affected By Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[936]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[447]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[936]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[893]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By Filamin A-interacting protein 1-like (FILIP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[327]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1450]

Drug(s) Affected By OTU domain-containing protein 7B (OTUD7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[793]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[506]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[332]

Drug(s) Affected By Rho GTPase-activating protein 30 (ARHGAP30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Pleckstrin homology domain-containing family H member 2 (PLEKHH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[402]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[464]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[879]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]

Drug(s) Affected By Extracellular sulfatase Sulf-1 (SULF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[459]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[388]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]

Drug(s) Affected By Cell division cycle and apoptosis regulator protein 1 (CCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[408]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[408]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[408]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[387]
Bortezomib	DMNO38U	Leukemia		Approved	[1451]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1452]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]

Drug(s) Affected By Histone H2B type 3-B (H2BC26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[432]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[282]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1453]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[515]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[1038]

Drug(s) Affected By DNA damage-regulated autophagy modulator protein 1 (DRAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[375]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[919]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[805]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1454]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[327]

Drug(s) Affected By Unconventional myosin-XVIIIa (MYO18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1455]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[1456]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[936]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[209]
Mestranol	DMG3F94	Contraception	QA21	Approved	[936]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[936]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[484]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[1457]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[1458]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[1459]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1460]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[817]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1454]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[1461]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[821]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1462]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]

Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1463]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1464]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1465]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[403]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Bortezomib	DMNO38U	Leukemia		Approved	[1466]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1467]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1468]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[570]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1469]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1470]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[899]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[378]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[364]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[364]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[364]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[1471]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[371]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 7 (BIRC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Bortezomib	DMNO38U	Leukemia		Approved	[1472]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[568]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1473]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1473]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1473]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1147]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1474]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[601]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1475]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[929]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[394]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[730]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[500]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[607]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]

Drug(s) Affected By M-phase phosphoprotein 6 (MPHOSPH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[449]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[465]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[466]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[941]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1476]
Selenium	DM25CGV	N. A.	N. A.	Approved	[182]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]

Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1477]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[506]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1478]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[1479]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1480]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[793]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1481]

Drug(s) Affected By Max dimerization protein 3 (MXD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1482]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1483]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[376]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[512]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By Synaptonemal complex protein 2 (SYCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[513]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[1484]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[1484]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[522]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1463]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[829]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[831]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1485]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[635]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1486]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1487]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1488]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[834]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[830]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1485]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1487]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1488]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1430]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1447]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1489]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[544]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]

Drug(s) Affected By Sideroflexin-1 (SFXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[793]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[481]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[628]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[628]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[324]

Drug(s) Affected By N-lysine methyltransferase KMT5A (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1490]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[793]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1491]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[882]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1319]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[299]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1492]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1493]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-7 (SIRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1494]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[309]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[508]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[466]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[881]
NORCANTHARIDIN	DM9B6Y1	Discovery agent	N.A.	Investigative	[1494]

Drug(s) Affected By Fanconi anemia group I protein (FANCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1463]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[458]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[1495]

Drug(s) Affected By Interferon kappa (IFNK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[515]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1496]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1496]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1497]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[159]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[1498]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[922]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1015]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1499]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[397]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1500]

Drug(s) Affected By Frizzled-1 (FZD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[175]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1501]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[175]

Drug(s) Affected By RAC-gamma serine/threonine-protein kinase (AKT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[386]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[814]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[628]

Drug(s) Affected By HBS1-like protein (HBS1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[338]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[433]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[332]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[1502]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[631]

Drug(s) Affected By Cysteine protease ATG4B (ATG4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[310]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[306]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[401]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[1503]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[475]

Drug(s) Affected By DNA (DNMT3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1215]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1504]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1221]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[622]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1490]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1505]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[365]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[230]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[365]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[607]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[266]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1033]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1107]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[205]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[944]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1506]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1507]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Albendazole monooxygenase (CYP3A4)	TTXV4FI	CP3A4_HUMAN	Inhibitor	[2]
Amyloid beta A4 protein (APP)	TTE4KHA	A4_HUMAN	Inhibitor	[3]
Carbonic anhydrase (CA)	TTUNARX	NOUNIPROTAC	Inhibitor	[4]
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[4]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[4]
Carbonic anhydrase IV (CA-IV)	TTZHA0O	CAH4_HUMAN	Inhibitor	[4]
Carbonic anhydrase IX (CA-IX)	TT2LVK8	CAH9_HUMAN	Inhibitor	[4]
Carbonic anhydrase VI (CA-VI)	TTCFSPE	CAH6_HUMAN	Inhibitor	[4]
Carbonic anhydrase XII (CA-XII)	TTSYM0R	CAH12_HUMAN	Inhibitor	[4]
Carbonic anhydrase XIV (CA-XIV)	TTEYTKG	CAH14_HUMAN	Inhibitor	[4]
DNA [cytosine-5]-methyltransferase (DNMT)	TTHVCUP	NOUNIPROTAC	Inhibitor	[5]
DNA [cytosine-5]-methyltransferase 3B (DNMT3B)	TT6VZ78	DNM3B_HUMAN	Inhibitor	[5]
Matrix metalloproteinase-13 (MMP-13)	TTHY57M	MMP13_HUMAN	Inhibitor	[6]
Matrix metalloproteinase-9 (MMP-9)	TT6X50U	MMP9_HUMAN	Inhibitor	[7]
Multidrug resistance protein (MDR)	TT0JLSD	NOUNIPROTAC	Inhibitor	[8]
Nitric-oxide synthase inducible (NOS2)	TTF10I9	NOS2_HUMAN	Inhibitor	[9]
Prostaglandin G/H synthase 1 (COX-1)	TT8NGED	PGH1_HUMAN	Inhibitor	[10]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[10]
Xanthine dehydrogenase/oxidase (XDH)	TT7RJY8	XDH_HUMAN	Inhibitor	[11]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[12]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[13]
UDP-glucuronosyltransferase 1A9 (UGT1A9)	DE85D2P	UD19_HUMAN	Substrate	[13]
UDP-glucuronosyltransferase 1A8 (UGT1A8)	DE2GB8N	UD18_HUMAN	Substrate	[13]
UDP-glucuronosyltransferase 1A7 (UGT1A7)	DEZO4N3	UD17_HUMAN	Substrate	[13]
NADPH-dependent curcumin reductase (curA)	DEZWDKE	CURA_ECOLI	Substrate	[14]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Gene/Protein Processing	[15]
14-3-3 protein epsilon	OT3WQXNA	1433E_HUMAN	Gene/Protein Processing	[16]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[17]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Post-Translational Modifications	[18]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[19]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Gene/Protein Processing	[20]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[21]
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4)	OT4CA13K	ATS4_HUMAN	Gene/Protein Processing	[22]
A-kinase anchor protein 6 (AKAP6)	OTN59BZS	AKAP6_HUMAN	Gene/Protein Processing	[23]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Post-Translational Modifications	[19]

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